Amino acid dipepetide frequency for Mesorhizobium ephedrae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	19.455AlaAla: 19.455 ± 0.15	0.998AlaCys: 0.998 ± 0.023	7.533AlaAsp: 7.533 ± 0.084	8.5AlaGlu: 8.5 ± 0.09	4.781AlaPhe: 4.781 ± 0.059	12.629AlaGly: 12.629 ± 0.101	2.076AlaHis: 2.076 ± 0.035	6.587AlaIle: 6.587 ± 0.066	3.977AlaLys: 3.977 ± 0.061	13.185AlaLeu: 13.185 ± 0.101	3.531AlaMet: 3.531 ± 0.045	2.773AlaAsn: 2.773 ± 0.038	5.403AlaPro: 5.403 ± 0.067	3.387AlaGln: 3.387 ± 0.049	9.1AlaArg: 9.1 ± 0.095	6.145AlaSer: 6.145 ± 0.062	5.925AlaThr: 5.925 ± 0.056	9.637AlaVal: 9.637 ± 0.07	1.532AlaTrp: 1.532 ± 0.025	2.663AlaTyr: 2.663 ± 0.041	0.0AlaXaa: 0.0 ± 0.0
Cys	0.898CysAla: 0.898 ± 0.024	0.107CysCys: 0.107 ± 0.009	0.476CysAsp: 0.476 ± 0.016	0.399CysGlu: 0.399 ± 0.015	0.352CysPhe: 0.352 ± 0.015	0.914CysGly: 0.914 ± 0.024	0.192CysHis: 0.192 ± 0.011	0.354CysIle: 0.354 ± 0.012	0.162CysLys: 0.162 ± 0.01	0.715CysLeu: 0.715 ± 0.021	0.16CysMet: 0.16 ± 0.01	0.183CysAsn: 0.183 ± 0.011	0.396CysPro: 0.396 ± 0.016	0.187CysGln: 0.187 ± 0.011	0.634CysArg: 0.634 ± 0.02	0.399CysSer: 0.399 ± 0.015	0.376CysThr: 0.376 ± 0.016	0.585CysVal: 0.585 ± 0.021	0.11CysTrp: 0.11 ± 0.007	0.205CysTyr: 0.205 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	6.895AspAla: 6.895 ± 0.062	0.473AspCys: 0.473 ± 0.018	3.184AspAsp: 3.184 ± 0.055	3.465AspGlu: 3.465 ± 0.051	2.405AspPhe: 2.405 ± 0.037	5.722AspGly: 5.722 ± 0.074	1.234AspHis: 1.234 ± 0.027	3.198AspIle: 3.198 ± 0.046	1.707AspLys: 1.707 ± 0.034	5.727AspLeu: 5.727 ± 0.06	1.378AspMet: 1.378 ± 0.028	1.294AspAsn: 1.294 ± 0.03	3.514AspPro: 3.514 ± 0.051	1.532AspGln: 1.532 ± 0.031	4.621AspArg: 4.621 ± 0.06	2.016AspSer: 2.016 ± 0.035	2.715AspThr: 2.715 ± 0.06	4.181AspVal: 4.181 ± 0.05	0.994AspTrp: 0.994 ± 0.024	1.515AspTyr: 1.515 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	8.148GluAla: 8.148 ± 0.076	0.314GluCys: 0.314 ± 0.014	2.687GluAsp: 2.687 ± 0.047	3.248GluGlu: 3.248 ± 0.059	1.825GluPhe: 1.825 ± 0.034	4.299GluGly: 4.299 ± 0.052	1.172GluHis: 1.172 ± 0.028	3.609GluIle: 3.609 ± 0.044	2.488GluLys: 2.488 ± 0.046	5.236GluLeu: 5.236 ± 0.057	1.502GluMet: 1.502 ± 0.033	1.599GluAsn: 1.599 ± 0.031	2.987GluPro: 2.987 ± 0.05	1.984GluGln: 1.984 ± 0.035	5.207GluArg: 5.207 ± 0.065	2.146GluSer: 2.146 ± 0.042	3.517GluThr: 3.517 ± 0.047	3.876GluVal: 3.876 ± 0.054	0.678GluTrp: 0.678 ± 0.02	0.912GluTyr: 0.912 ± 0.022	0.0GluXaa: 0.0 ± 0.0
Phe	4.987PheAla: 4.987 ± 0.059	0.394PheCys: 0.394 ± 0.015	2.821PheAsp: 2.821 ± 0.049	2.179PheGlu: 2.179 ± 0.036	1.57PhePhe: 1.57 ± 0.037	3.968PheGly: 3.968 ± 0.05	0.787PheHis: 0.787 ± 0.021	1.687PheIle: 1.687 ± 0.035	0.894PheLys: 0.894 ± 0.025	3.568PheLeu: 3.568 ± 0.048	0.796PheMet: 0.796 ± 0.02	0.995PheAsn: 0.995 ± 0.026	1.678PhePro: 1.678 ± 0.032	1.032PheGln: 1.032 ± 0.025	2.496PheArg: 2.496 ± 0.04	2.315PheSer: 2.315 ± 0.035	1.904PheThr: 1.904 ± 0.034	3.11PheVal: 3.11 ± 0.045	0.585PheTrp: 0.585 ± 0.02	0.928PheTyr: 0.928 ± 0.024	0.0PheXaa: 0.0 ± 0.0
Gly	9.758GlyAla: 9.758 ± 0.091	0.806GlyCys: 0.806 ± 0.022	4.834GlyAsp: 4.834 ± 0.08	5.214GlyGlu: 5.214 ± 0.062	3.85GlyPhe: 3.85 ± 0.046	8.438GlyGly: 8.438 ± 0.136	1.896GlyHis: 1.896 ± 0.037	4.99GlyIle: 4.99 ± 0.06	3.532GlyLys: 3.532 ± 0.044	9.167GlyLeu: 9.167 ± 0.076	2.513GlyMet: 2.513 ± 0.039	2.358GlyAsn: 2.358 ± 0.062	3.583GlyPro: 3.583 ± 0.047	2.686GlyGln: 2.686 ± 0.039	6.784GlyArg: 6.784 ± 0.065	4.813GlySer: 4.813 ± 0.071	4.779GlyThr: 4.779 ± 0.066	6.467GlyVal: 6.467 ± 0.063	1.434GlyTrp: 1.434 ± 0.031	2.364GlyTyr: 2.364 ± 0.039	0.0GlyXaa: 0.0 ± 0.0
His	2.345HisAla: 2.345 ± 0.04	0.207HisCys: 0.207 ± 0.011	1.227HisAsp: 1.227 ± 0.024	1.031HisGlu: 1.031 ± 0.023	0.886HisPhe: 0.886 ± 0.021	2.002HisGly: 2.002 ± 0.033	0.548HisHis: 0.548 ± 0.021	0.88HisIle: 0.88 ± 0.023	0.479HisLys: 0.479 ± 0.017	1.915HisLeu: 1.915 ± 0.039	0.498HisMet: 0.498 ± 0.015	0.421HisAsn: 0.421 ± 0.014	1.279HisPro: 1.279 ± 0.025	0.513HisGln: 0.513 ± 0.017	1.391HisArg: 1.391 ± 0.03	0.857HisSer: 0.857 ± 0.025	0.733HisThr: 0.733 ± 0.02	1.568HisVal: 1.568 ± 0.031	0.325HisTrp: 0.325 ± 0.016	0.512HisTyr: 0.512 ± 0.022	0.0HisXaa: 0.0 ± 0.0
Ile	7.459IleAla: 7.459 ± 0.072	0.456IleCys: 0.456 ± 0.018	3.66IleAsp: 3.66 ± 0.051	3.467IleGlu: 3.467 ± 0.038	1.8IlePhe: 1.8 ± 0.032	5.193IleGly: 5.193 ± 0.061	0.905IleHis: 0.905 ± 0.023	2.062IleIle: 2.062 ± 0.041	1.307IleLys: 1.307 ± 0.027	4.356IleLeu: 4.356 ± 0.058	1.007IleMet: 1.007 ± 0.023	1.3IleAsn: 1.3 ± 0.027	2.272IlePro: 2.272 ± 0.039	1.048IleGln: 1.048 ± 0.023	3.392IleArg: 3.392 ± 0.044	2.713IleSer: 2.713 ± 0.039	2.383IleThr: 2.383 ± 0.037	4.723IleVal: 4.723 ± 0.058	0.548IleTrp: 0.548 ± 0.019	1.114IleTyr: 1.114 ± 0.025	0.0IleXaa: 0.0 ± 0.0
Lys	4.364LysAla: 4.364 ± 0.058	0.149LysCys: 0.149 ± 0.01	1.713LysAsp: 1.713 ± 0.033	1.504LysGlu: 1.504 ± 0.037	0.923LysPhe: 0.923 ± 0.026	2.65LysGly: 2.65 ± 0.046	0.607LysHis: 0.607 ± 0.018	1.722LysIle: 1.722 ± 0.036	1.252LysLys: 1.252 ± 0.029	3.259LysLeu: 3.259 ± 0.05	0.741LysMet: 0.741 ± 0.022	0.821LysAsn: 0.821 ± 0.029	2.14LysPro: 2.14 ± 0.043	0.963LysGln: 0.963 ± 0.023	2.343LysArg: 2.343 ± 0.041	1.751LysSer: 1.751 ± 0.033	1.881LysThr: 1.881 ± 0.029	2.582LysVal: 2.582 ± 0.043	0.393LysTrp: 0.393 ± 0.017	0.61LysTyr: 0.61 ± 0.019	0.0LysXaa: 0.0 ± 0.0
Leu	14.098LeuAla: 14.098 ± 0.108	0.84LeuCys: 0.84 ± 0.02	6.108LeuAsp: 6.108 ± 0.061	5.115LeuGlu: 5.115 ± 0.056	3.725LeuPhe: 3.725 ± 0.051	8.431LeuGly: 8.431 ± 0.077	1.761LeuHis: 1.761 ± 0.029	4.665LeuIle: 4.665 ± 0.064	3.579LeuLys: 3.579 ± 0.052	9.261LeuLeu: 9.261 ± 0.093	2.187LeuMet: 2.187 ± 0.035	2.29LeuAsn: 2.29 ± 0.043	5.412LeuPro: 5.412 ± 0.055	2.422LeuGln: 2.422 ± 0.035	6.616LeuArg: 6.616 ± 0.059	6.252LeuSer: 6.252 ± 0.061	5.106LeuThr: 5.106 ± 0.059	7.82LeuVal: 7.82 ± 0.08	1.11LeuTrp: 1.11 ± 0.028	2.086LeuTyr: 2.086 ± 0.034	0.0LeuXaa: 0.0 ± 0.0
Met	3.243MetAla: 3.243 ± 0.044	0.141MetCys: 0.141 ± 0.01	1.076MetAsp: 1.076 ± 0.02	1.104MetGlu: 1.104 ± 0.023	0.68MetPhe: 0.68 ± 0.02	1.684MetGly: 1.684 ± 0.032	0.438MetHis: 0.438 ± 0.013	1.348MetIle: 1.348 ± 0.03	1.011MetLys: 1.011 ± 0.024	2.545MetLeu: 2.545 ± 0.039	0.648MetMet: 0.648 ± 0.02	0.756MetAsn: 0.756 ± 0.023	1.515MetPro: 1.515 ± 0.031	0.812MetGln: 0.812 ± 0.02	1.888MetArg: 1.888 ± 0.033	1.568MetSer: 1.568 ± 0.031	1.818MetThr: 1.818 ± 0.033	1.721MetVal: 1.721 ± 0.035	0.201MetTrp: 0.201 ± 0.01	0.295MetTyr: 0.295 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.075AsnAla: 3.075 ± 0.045	0.217AsnCys: 0.217 ± 0.01	1.423AsnAsp: 1.423 ± 0.038	1.16AsnGlu: 1.16 ± 0.028	0.951AsnPhe: 0.951 ± 0.022	2.425AsnGly: 2.425 ± 0.044	0.476AsnHis: 0.476 ± 0.015	1.3AsnIle: 1.3 ± 0.027	0.589AsnLys: 0.589 ± 0.018	2.392AsnLeu: 2.392 ± 0.043	0.598AsnMet: 0.598 ± 0.019	0.614AsnAsn: 0.614 ± 0.019	1.788AsnPro: 1.788 ± 0.031	0.673AsnGln: 0.673 ± 0.02	1.749AsnArg: 1.749 ± 0.034	1.117AsnSer: 1.117 ± 0.027	1.146AsnThr: 1.146 ± 0.029	1.913AsnVal: 1.913 ± 0.032	0.397AsnTrp: 0.397 ± 0.015	0.646AsnTyr: 0.646 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	6.932ProAla: 6.932 ± 0.083	0.308ProCys: 0.308 ± 0.014	3.66ProAsp: 3.66 ± 0.048	3.558ProGlu: 3.558 ± 0.059	2.038ProPhe: 2.038 ± 0.038	4.621ProGly: 4.621 ± 0.057	1.011ProHis: 1.011 ± 0.028	2.232ProIle: 2.232 ± 0.037	1.681ProLys: 1.681 ± 0.032	4.776ProLeu: 4.776 ± 0.057	1.133ProMet: 1.133 ± 0.029	1.239ProAsn: 1.239 ± 0.026	2.488ProPro: 2.488 ± 0.052	1.55ProGln: 1.55 ± 0.033	3.141ProArg: 3.141 ± 0.047	2.701ProSer: 2.701 ± 0.043	2.364ProThr: 2.364 ± 0.036	4.281ProVal: 4.281 ± 0.05	0.698ProTrp: 0.698 ± 0.022	1.231ProTyr: 1.231 ± 0.028	0.0ProXaa: 0.0 ± 0.0
Gln	3.892GlnAla: 3.892 ± 0.048	0.182GlnCys: 0.182 ± 0.011	1.267GlnAsp: 1.267 ± 0.025	1.38GlnGlu: 1.38 ± 0.028	0.995GlnPhe: 0.995 ± 0.022	2.172GlnGly: 2.172 ± 0.033	0.548GlnHis: 0.548 ± 0.016	1.554GlnIle: 1.554 ± 0.032	1.033GlnLys: 1.033 ± 0.025	2.508GlnLeu: 2.508 ± 0.044	0.816GlnMet: 0.816 ± 0.02	0.744GlnAsn: 0.744 ± 0.021	1.737GlnPro: 1.737 ± 0.034	1.044GlnGln: 1.044 ± 0.028	2.233GlnArg: 2.233 ± 0.039	1.509GlnSer: 1.509 ± 0.035	1.446GlnThr: 1.446 ± 0.033	2.045GlnVal: 2.045 ± 0.035	0.368GlnTrp: 0.368 ± 0.014	0.536GlnTyr: 0.536 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	8.079ArgAla: 8.079 ± 0.092	0.5ArgCys: 0.5 ± 0.019	4.197ArgAsp: 4.197 ± 0.05	4.19ArgGlu: 4.19 ± 0.052	3.122ArgPhe: 3.122 ± 0.041	5.113ArgGly: 5.113 ± 0.068	1.802ArgHis: 1.802 ± 0.033	4.097ArgIle: 4.097 ± 0.051	2.524ArgLys: 2.524 ± 0.039	8.087ArgLeu: 8.087 ± 0.082	1.916ArgMet: 1.916 ± 0.036	1.8ArgAsn: 1.8 ± 0.035	3.92ArgPro: 3.92 ± 0.055	2.597ArgGln: 2.597 ± 0.042	6.233ArgArg: 6.233 ± 0.077	3.704ArgSer: 3.704 ± 0.053	3.495ArgThr: 3.495 ± 0.044	4.641ArgVal: 4.641 ± 0.059	0.952ArgTrp: 0.952 ± 0.024	1.751ArgTyr: 1.751 ± 0.032	0.0ArgXaa: 0.0 ± 0.0
Ser	6.15SerAla: 6.15 ± 0.062	0.381SerCys: 0.381 ± 0.018	2.775SerAsp: 2.775 ± 0.035	2.577SerGlu: 2.577 ± 0.04	2.265SerPhe: 2.265 ± 0.041	5.698SerGly: 5.698 ± 0.07	1.026SerHis: 1.026 ± 0.026	2.649SerIle: 2.649 ± 0.048	1.446SerLys: 1.446 ± 0.031	5.181SerLeu: 5.181 ± 0.058	1.274SerMet: 1.274 ± 0.026	1.24SerAsn: 1.24 ± 0.031	2.787SerPro: 2.787 ± 0.044	1.36SerGln: 1.36 ± 0.03	3.614SerArg: 3.614 ± 0.05	2.678SerSer: 2.678 ± 0.047	2.566SerThr: 2.566 ± 0.045	4.01SerVal: 4.01 ± 0.046	0.752SerTrp: 0.752 ± 0.021	1.192SerTyr: 1.192 ± 0.026	0.0SerXaa: 0.0 ± 0.0
Thr	6.221ThrAla: 6.221 ± 0.066	0.359ThrCys: 0.359 ± 0.016	2.658ThrAsp: 2.658 ± 0.042	2.589ThrGlu: 2.589 ± 0.039	2.007ThrPhe: 2.007 ± 0.038	5.223ThrGly: 5.223 ± 0.075	0.93ThrHis: 0.93 ± 0.021	2.946ThrIle: 2.946 ± 0.04	1.316ThrLys: 1.316 ± 0.027	5.537ThrLeu: 5.537 ± 0.057	1.173ThrMet: 1.173 ± 0.027	1.185ThrAsn: 1.185 ± 0.028	3.001ThrPro: 3.001 ± 0.042	1.216ThrGln: 1.216 ± 0.027	3.186ThrArg: 3.186 ± 0.041	2.501ThrSer: 2.501 ± 0.044	2.721ThrThr: 2.721 ± 0.043	4.502ThrVal: 4.502 ± 0.065	0.636ThrTrp: 0.636 ± 0.021	1.161ThrTyr: 1.161 ± 0.025	0.0ThrXaa: 0.0 ± 0.0
Val	10.042ValAla: 10.042 ± 0.078	0.585ValCys: 0.585 ± 0.017	4.378ValAsp: 4.378 ± 0.053	4.944ValGlu: 4.944 ± 0.059	3.026ValPhe: 3.026 ± 0.048	6.045ValGly: 6.045 ± 0.062	1.413ValHis: 1.413 ± 0.028	3.814ValIle: 3.814 ± 0.056	2.304ValLys: 2.304 ± 0.038	7.672ValLeu: 7.672 ± 0.074	1.842ValMet: 1.842 ± 0.031	1.988ValAsn: 1.988 ± 0.035	3.932ValPro: 3.932 ± 0.051	1.819ValGln: 1.819 ± 0.03	5.129ValArg: 5.129 ± 0.057	4.448ValSer: 4.448 ± 0.058	4.327ValThr: 4.327 ± 0.048	6.433ValVal: 6.433 ± 0.075	0.929ValTrp: 0.929 ± 0.022	1.541ValTyr: 1.541 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.234TrpAla: 1.234 ± 0.027	0.134TrpCys: 0.134 ± 0.009	0.619TrpAsp: 0.619 ± 0.019	0.56TrpGlu: 0.56 ± 0.017	0.556TrpPhe: 0.556 ± 0.02	0.884TrpGly: 0.884 ± 0.023	0.334TrpHis: 0.334 ± 0.013	0.652TrpIle: 0.652 ± 0.021	0.494TrpLys: 0.494 ± 0.018	1.572TrpLeu: 1.572 ± 0.033	0.337TrpMet: 0.337 ± 0.015	0.485TrpAsn: 0.485 ± 0.017	0.699TrpPro: 0.699 ± 0.02	0.539TrpGln: 0.539 ± 0.016	1.147TrpArg: 1.147 ± 0.025	0.871TrpSer: 0.871 ± 0.022	0.803TrpThr: 0.803 ± 0.022	0.779TrpVal: 0.779 ± 0.02	0.237TrpTrp: 0.237 ± 0.013	0.295TrpTyr: 0.295 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.544TyrAla: 2.544 ± 0.034	0.256TyrCys: 0.256 ± 0.012	1.474TyrAsp: 1.474 ± 0.03	1.246TyrGlu: 1.246 ± 0.024	0.937TyrPhe: 0.937 ± 0.021	2.152TyrGly: 2.152 ± 0.033	0.462TyrHis: 0.462 ± 0.017	0.818TyrIle: 0.818 ± 0.022	0.593TyrLys: 0.593 ± 0.019	2.224TyrLeu: 2.224 ± 0.037	0.443TyrMet: 0.443 ± 0.019	0.565TyrAsn: 0.565 ± 0.021	1.111TyrPro: 1.111 ± 0.03	0.647TyrGln: 0.647 ± 0.018	1.817TyrArg: 1.817 ± 0.035	1.114TyrSer: 1.114 ± 0.023	1.063TyrThr: 1.063 ± 0.026	1.739TyrVal: 1.739 ± 0.032	0.354TyrTrp: 0.354 ± 0.015	0.576TyrTyr: 0.576 ± 0.019	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5676 proteins (1760207 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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