Amino acid dipepetide frequency for Alteriqipengyuania halimionae

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	16.131AlaAla: 16.131 ± 0.211	1.047AlaCys: 1.047 ± 0.035	7.53AlaAsp: 7.53 ± 0.133	8.351AlaGlu: 8.351 ± 0.124	4.167AlaPhe: 4.167 ± 0.077	10.29AlaGly: 10.29 ± 0.114	2.069AlaHis: 2.069 ± 0.051	7.128AlaIle: 7.128 ± 0.105	4.446AlaLys: 4.446 ± 0.082	13.55AlaLeu: 13.55 ± 0.175	3.757AlaMet: 3.757 ± 0.064	3.217AlaAsn: 3.217 ± 0.071	5.744AlaPro: 5.744 ± 0.097	4.435AlaGln: 4.435 ± 0.071	9.084AlaArg: 9.084 ± 0.12	6.562AlaSer: 6.562 ± 0.1	6.133AlaThr: 6.133 ± 0.12	7.792AlaVal: 7.792 ± 0.089	1.581AlaTrp: 1.581 ± 0.043	2.527AlaTyr: 2.527 ± 0.06	0.0AlaXaa: 0.0 ± 0.0
Cys	0.998CysAla: 0.998 ± 0.036	0.068CysCys: 0.068 ± 0.009	0.618CysAsp: 0.618 ± 0.028	0.479CysGlu: 0.479 ± 0.025	0.267CysPhe: 0.267 ± 0.019	0.837CysGly: 0.837 ± 0.031	0.187CysHis: 0.187 ± 0.015	0.329CysIle: 0.329 ± 0.019	0.183CysLys: 0.183 ± 0.015	0.677CysLeu: 0.677 ± 0.025	0.128CysMet: 0.128 ± 0.012	0.223CysAsn: 0.223 ± 0.016	0.398CysPro: 0.398 ± 0.022	0.19CysGln: 0.19 ± 0.014	0.503CysArg: 0.503 ± 0.026	0.465CysSer: 0.465 ± 0.03	0.349CysThr: 0.349 ± 0.023	0.589CysVal: 0.589 ± 0.03	0.106CysTrp: 0.106 ± 0.011	0.175CysTyr: 0.175 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	8.18AspAla: 8.18 ± 0.111	0.566AspCys: 0.566 ± 0.026	4.372AspAsp: 4.372 ± 0.085	4.729AspGlu: 4.729 ± 0.077	2.416AspPhe: 2.416 ± 0.05	6.388AspGly: 6.388 ± 0.108	1.318AspHis: 1.318 ± 0.046	3.167AspIle: 3.167 ± 0.061	2.062AspLys: 2.062 ± 0.058	5.996AspLeu: 5.996 ± 0.084	1.532AspMet: 1.532 ± 0.041	1.707AspAsn: 1.707 ± 0.048	3.917AspPro: 3.917 ± 0.063	1.868AspGln: 1.868 ± 0.046	5.048AspArg: 5.048 ± 0.08	2.754AspSer: 2.754 ± 0.06	3.221AspThr: 3.221 ± 0.068	4.279AspVal: 4.279 ± 0.075	1.184AspTrp: 1.184 ± 0.042	1.727AspTyr: 1.727 ± 0.048	0.0AspXaa: 0.0 ± 0.0
Glu	8.445GluAla: 8.445 ± 0.113	0.416GluCys: 0.416 ± 0.022	4.098GluAsp: 4.098 ± 0.08	4.219GluGlu: 4.219 ± 0.087	1.95GluPhe: 1.95 ± 0.051	5.403GluGly: 5.403 ± 0.078	1.273GluHis: 1.273 ± 0.036	3.422GluIle: 3.422 ± 0.063	2.592GluLys: 2.592 ± 0.061	5.889GluLeu: 5.889 ± 0.096	1.662GluMet: 1.662 ± 0.046	1.885GluAsn: 1.885 ± 0.052	3.007GluPro: 3.007 ± 0.061	2.465GluGln: 2.465 ± 0.052	5.719GluArg: 5.719 ± 0.1	2.91GluSer: 2.91 ± 0.057	3.74GluThr: 3.74 ± 0.061	3.944GluVal: 3.944 ± 0.065	0.945GluTrp: 0.945 ± 0.035	1.267GluTyr: 1.267 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	4.989PheAla: 4.989 ± 0.071	0.327PheCys: 0.327 ± 0.022	2.943PheAsp: 2.943 ± 0.063	2.327PheGlu: 2.327 ± 0.058	1.329PhePhe: 1.329 ± 0.047	3.718PheGly: 3.718 ± 0.072	0.668PheHis: 0.668 ± 0.027	1.483PheIle: 1.483 ± 0.048	0.849PheLys: 0.849 ± 0.04	3.032PheLeu: 3.032 ± 0.059	0.787PheMet: 0.787 ± 0.028	0.984PheAsn: 0.984 ± 0.035	1.473PhePro: 1.473 ± 0.044	0.897PheGln: 0.897 ± 0.034	2.055PheArg: 2.055 ± 0.05	2.089PheSer: 2.089 ± 0.051	1.929PheThr: 1.929 ± 0.044	2.684PheVal: 2.684 ± 0.061	0.514PheTrp: 0.514 ± 0.028	0.987PheTyr: 0.987 ± 0.035	0.0PheXaa: 0.0 ± 0.0
Gly	9.65GlyAla: 9.65 ± 0.103	0.76GlyCys: 0.76 ± 0.031	5.486GlyAsp: 5.486 ± 0.092	6.102GlyGlu: 6.102 ± 0.083	3.634GlyPhe: 3.634 ± 0.072	8.04GlyGly: 8.04 ± 0.137	1.689GlyHis: 1.689 ± 0.05	4.365GlyIle: 4.365 ± 0.079	3.483GlyLys: 3.483 ± 0.067	8.125GlyLeu: 8.125 ± 0.11	2.324GlyMet: 2.324 ± 0.055	2.437GlyAsn: 2.437 ± 0.058	3.557GlyPro: 3.557 ± 0.071	2.829GlyGln: 2.829 ± 0.063	5.881GlyArg: 5.881 ± 0.089	4.964GlySer: 4.964 ± 0.092	4.821GlyThr: 4.821 ± 0.098	5.864GlyVal: 5.864 ± 0.087	1.601GlyTrp: 1.601 ± 0.049	2.319GlyTyr: 2.319 ± 0.062	0.0GlyXaa: 0.0 ± 0.0
His	2.173HisAla: 2.173 ± 0.062	0.239HisCys: 0.239 ± 0.018	1.268HisAsp: 1.268 ± 0.042	1.144HisGlu: 1.144 ± 0.034	0.77HisPhe: 0.77 ± 0.029	1.777HisGly: 1.777 ± 0.053	0.469HisHis: 0.469 ± 0.025	0.82HisIle: 0.82 ± 0.033	0.448HisLys: 0.448 ± 0.021	1.669HisLeu: 1.669 ± 0.045	0.378HisMet: 0.378 ± 0.023	0.429HisAsn: 0.429 ± 0.023	1.185HisPro: 1.185 ± 0.041	0.487HisGln: 0.487 ± 0.023	1.351HisArg: 1.351 ± 0.041	0.91HisSer: 0.91 ± 0.035	0.822HisThr: 0.822 ± 0.034	1.246HisVal: 1.246 ± 0.037	0.308HisTrp: 0.308 ± 0.021	0.554HisTyr: 0.554 ± 0.023	0.0HisXaa: 0.0 ± 0.0
Ile	8.025IleAla: 8.025 ± 0.105	0.43IleCys: 0.43 ± 0.023	4.108IleAsp: 4.108 ± 0.066	4.087IleGlu: 4.087 ± 0.068	1.548IlePhe: 1.548 ± 0.046	5.265IleGly: 5.265 ± 0.085	0.799IleHis: 0.799 ± 0.031	1.842IleIle: 1.842 ± 0.055	1.237IleLys: 1.237 ± 0.044	3.793IleLeu: 3.793 ± 0.078	0.916IleMet: 0.916 ± 0.032	1.255IleAsn: 1.255 ± 0.04	2.312IlePro: 2.312 ± 0.055	1.043IleGln: 1.043 ± 0.039	3.076IleArg: 3.076 ± 0.045	2.452IleSer: 2.452 ± 0.059	2.455IleThr: 2.455 ± 0.059	4.05IleVal: 4.05 ± 0.08	0.549IleTrp: 0.549 ± 0.022	1.07IleTyr: 1.07 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	4.049LysAla: 4.049 ± 0.098	0.166LysCys: 0.166 ± 0.015	1.893LysAsp: 1.893 ± 0.055	1.547LysGlu: 1.547 ± 0.049	0.946LysPhe: 0.946 ± 0.03	2.666LysGly: 2.666 ± 0.059	0.612LysHis: 0.612 ± 0.028	1.595LysIle: 1.595 ± 0.045	1.4LysLys: 1.4 ± 0.06	3.351LysLeu: 3.351 ± 0.069	0.845LysMet: 0.845 ± 0.035	0.82LysAsn: 0.82 ± 0.033	1.92LysPro: 1.92 ± 0.055	1.083LysGln: 1.083 ± 0.04	2.583LysArg: 2.583 ± 0.06	1.81LysSer: 1.81 ± 0.042	1.717LysThr: 1.717 ± 0.045	2.297LysVal: 2.297 ± 0.062	0.44LysTrp: 0.44 ± 0.021	0.653LysTyr: 0.653 ± 0.03	0.0LysXaa: 0.0 ± 0.0
Leu	13.759LeuAla: 13.759 ± 0.184	0.691LeuCys: 0.691 ± 0.029	6.659LeuAsp: 6.659 ± 0.104	5.606LeuGlu: 5.606 ± 0.077	3.557LeuPhe: 3.557 ± 0.077	8.149LeuGly: 8.149 ± 0.112	1.664LeuHis: 1.664 ± 0.046	4.343LeuIle: 4.343 ± 0.08	2.939LeuLys: 2.939 ± 0.066	8.898LeuLeu: 8.898 ± 0.138	2.079LeuMet: 2.079 ± 0.053	2.169LeuAsn: 2.169 ± 0.046	5.024LeuPro: 5.024 ± 0.084	2.484LeuGln: 2.484 ± 0.051	6.565LeuArg: 6.565 ± 0.103	5.762LeuSer: 5.762 ± 0.076	5.206LeuThr: 5.206 ± 0.089	7.496LeuVal: 7.496 ± 0.107	1.154LeuTrp: 1.154 ± 0.044	1.954LeuTyr: 1.954 ± 0.049	0.0LeuXaa: 0.0 ± 0.0
Met	3.048MetAla: 3.048 ± 0.056	0.159MetCys: 0.159 ± 0.014	1.214MetAsp: 1.214 ± 0.04	1.259MetGlu: 1.259 ± 0.041	0.681MetPhe: 0.681 ± 0.029	1.893MetGly: 1.893 ± 0.056	0.458MetHis: 0.458 ± 0.023	1.295MetIle: 1.295 ± 0.038	1.014MetLys: 1.014 ± 0.039	2.592MetLeu: 2.592 ± 0.062	0.639MetMet: 0.639 ± 0.03	0.648MetAsn: 0.648 ± 0.026	1.381MetPro: 1.381 ± 0.038	0.8MetGln: 0.8 ± 0.033	1.837MetArg: 1.837 ± 0.047	1.45MetSer: 1.45 ± 0.04	1.609MetThr: 1.609 ± 0.042	1.61MetVal: 1.61 ± 0.044	0.249MetTrp: 0.249 ± 0.02	0.253MetTyr: 0.253 ± 0.017	0.0MetXaa: 0.0 ± 0.0
Asn	3.346AsnAla: 3.346 ± 0.071	0.252AsnCys: 0.252 ± 0.019	1.585AsnAsp: 1.585 ± 0.042	1.376AsnGlu: 1.376 ± 0.039	0.981AsnPhe: 0.981 ± 0.042	2.483AsnGly: 2.483 ± 0.066	0.503AsnHis: 0.503 ± 0.026	1.259AsnIle: 1.259 ± 0.039	0.666AsnLys: 0.666 ± 0.028	2.434AsnLeu: 2.434 ± 0.056	0.549AsnMet: 0.549 ± 0.024	0.681AsnAsn: 0.681 ± 0.033	1.766AsnPro: 1.766 ± 0.052	0.704AsnGln: 0.704 ± 0.026	1.92AsnArg: 1.92 ± 0.045	1.309AsnSer: 1.309 ± 0.045	1.169AsnThr: 1.169 ± 0.045	1.852AsnVal: 1.852 ± 0.047	0.395AsnTrp: 0.395 ± 0.022	0.699AsnTyr: 0.699 ± 0.033	0.0AsnXaa: 0.0 ± 0.0
Pro	5.772ProAla: 5.772 ± 0.084	0.312ProCys: 0.312 ± 0.021	4.079ProAsp: 4.079 ± 0.076	4.213ProGlu: 4.213 ± 0.076	1.926ProPhe: 1.926 ± 0.047	4.463ProGly: 4.463 ± 0.079	0.955ProHis: 0.955 ± 0.036	2.446ProIle: 2.446 ± 0.053	1.603ProLys: 1.603 ± 0.043	4.562ProLeu: 4.562 ± 0.084	1.119ProMet: 1.119 ± 0.035	1.157ProAsn: 1.157 ± 0.04	2.559ProPro: 2.559 ± 0.103	1.724ProGln: 1.724 ± 0.05	2.819ProArg: 2.819 ± 0.064	2.705ProSer: 2.705 ± 0.061	2.561ProThr: 2.561 ± 0.062	3.893ProVal: 3.893 ± 0.075	0.611ProTrp: 0.611 ± 0.027	1.098ProTyr: 1.098 ± 0.038	0.0ProXaa: 0.0 ± 0.0
Gln	3.886GlnAla: 3.886 ± 0.078	0.201GlnCys: 0.201 ± 0.014	1.775GlnAsp: 1.775 ± 0.047	1.581GlnGlu: 1.581 ± 0.042	1.135GlnPhe: 1.135 ± 0.038	2.385GlnGly: 2.385 ± 0.05	0.516GlnHis: 0.516 ± 0.027	1.687GlnIle: 1.687 ± 0.046	0.883GlnLys: 0.883 ± 0.038	3.096GlnLeu: 3.096 ± 0.058	0.808GlnMet: 0.808 ± 0.031	0.747GlnAsn: 0.747 ± 0.036	1.655GlnPro: 1.655 ± 0.044	1.135GlnGln: 1.135 ± 0.04	2.48GlnArg: 2.48 ± 0.061	1.78GlnSer: 1.78 ± 0.048	1.58GlnThr: 1.58 ± 0.044	2.284GlnVal: 2.284 ± 0.047	0.402GlnTrp: 0.402 ± 0.025	0.65GlnTyr: 0.65 ± 0.028	0.0GlnXaa: 0.0 ± 0.0
Arg	8.209ArgAla: 8.209 ± 0.125	0.46ArgCys: 0.46 ± 0.023	4.842ArgAsp: 4.842 ± 0.075	5.068ArgGlu: 5.068 ± 0.078	2.943ArgPhe: 2.943 ± 0.063	4.958ArgGly: 4.958 ± 0.085	1.421ArgHis: 1.421 ± 0.043	4.07ArgIle: 4.07 ± 0.068	2.465ArgLys: 2.465 ± 0.049	7.301ArgLeu: 7.301 ± 0.116	1.87ArgMet: 1.87 ± 0.047	1.929ArgAsn: 1.929 ± 0.047	3.194ArgPro: 3.194 ± 0.06	2.373ArgGln: 2.373 ± 0.054	5.298ArgArg: 5.298 ± 0.101	3.605ArgSer: 3.605 ± 0.07	3.402ArgThr: 3.402 ± 0.066	4.557ArgVal: 4.557 ± 0.076	1.119ArgTrp: 1.119 ± 0.04	1.896ArgTyr: 1.896 ± 0.048	0.0ArgXaa: 0.0 ± 0.0
Ser	6.273SerAla: 6.273 ± 0.099	0.349SerCys: 0.349 ± 0.021	3.624SerAsp: 3.624 ± 0.062	3.308SerGlu: 3.308 ± 0.064	2.107SerPhe: 2.107 ± 0.051	5.536SerGly: 5.536 ± 0.075	0.916SerHis: 0.916 ± 0.032	2.659SerIle: 2.659 ± 0.055	1.603SerLys: 1.603 ± 0.046	4.993SerLeu: 4.993 ± 0.071	1.182SerMet: 1.182 ± 0.036	1.421SerAsn: 1.421 ± 0.043	2.831SerPro: 2.831 ± 0.06	1.649SerGln: 1.649 ± 0.047	3.459SerArg: 3.459 ± 0.071	2.936SerSer: 2.936 ± 0.071	2.73SerThr: 2.73 ± 0.071	3.608SerVal: 3.608 ± 0.075	0.751SerTrp: 0.751 ± 0.027	1.345SerTyr: 1.345 ± 0.046	0.0SerXaa: 0.0 ± 0.0
Thr	5.988ThrAla: 5.988 ± 0.114	0.392ThrCys: 0.392 ± 0.023	3.218ThrAsp: 3.218 ± 0.063	2.779ThrGlu: 2.779 ± 0.058	1.858ThrPhe: 1.858 ± 0.053	5.119ThrGly: 5.119 ± 0.087	0.898ThrHis: 0.898 ± 0.034	3.095ThrIle: 3.095 ± 0.056	1.435ThrLys: 1.435 ± 0.048	5.658ThrLeu: 5.658 ± 0.083	1.147ThrMet: 1.147 ± 0.039	1.336ThrAsn: 1.336 ± 0.046	3.243ThrPro: 3.243 ± 0.06	1.454ThrGln: 1.454 ± 0.039	3.382ThrArg: 3.382 ± 0.057	2.71ThrSer: 2.71 ± 0.052	2.694ThrThr: 2.694 ± 0.071	4.0ThrVal: 4.0 ± 0.072	0.51ThrTrp: 0.51 ± 0.025	1.185ThrTyr: 1.185 ± 0.045	0.0ThrXaa: 0.0 ± 0.0
Val	8.779ValAla: 8.779 ± 0.129	0.596ValCys: 0.596 ± 0.029	4.581ValAsp: 4.581 ± 0.067	4.983ValGlu: 4.983 ± 0.078	2.396ValPhe: 2.396 ± 0.052	5.467ValGly: 5.467 ± 0.092	1.237ValHis: 1.237 ± 0.039	3.641ValIle: 3.641 ± 0.069	2.086ValLys: 2.086 ± 0.052	6.649ValLeu: 6.649 ± 0.113	1.624ValMet: 1.624 ± 0.045	1.807ValAsn: 1.807 ± 0.052	3.696ValPro: 3.696 ± 0.071	1.816ValGln: 1.816 ± 0.048	4.617ValArg: 4.617 ± 0.072	4.057ValSer: 4.057 ± 0.076	4.122ValThr: 4.122 ± 0.082	5.205ValVal: 5.205 ± 0.092	0.855ValTrp: 0.855 ± 0.034	1.334ValTyr: 1.334 ± 0.046	0.0ValXaa: 0.0 ± 0.0
Trp	1.279TrpAla: 1.279 ± 0.044	0.132TrpCys: 0.132 ± 0.012	0.782TrpAsp: 0.782 ± 0.031	0.671TrpGlu: 0.671 ± 0.034	0.592TrpPhe: 0.592 ± 0.027	0.918TrpGly: 0.918 ± 0.034	0.33TrpHis: 0.33 ± 0.019	0.752TrpIle: 0.752 ± 0.036	0.45TrpLys: 0.45 ± 0.024	1.732TrpLeu: 1.732 ± 0.052	0.347TrpMet: 0.347 ± 0.023	0.461TrpAsn: 0.461 ± 0.022	0.634TrpPro: 0.634 ± 0.028	0.603TrpGln: 0.603 ± 0.029	1.275TrpArg: 1.275 ± 0.039	0.827TrpSer: 0.827 ± 0.034	0.767TrpThr: 0.767 ± 0.032	0.781TrpVal: 0.781 ± 0.031	0.3TrpTrp: 0.3 ± 0.02	0.286TrpTyr: 0.286 ± 0.018	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.561TyrAla: 2.561 ± 0.06	0.208TyrCys: 0.208 ± 0.015	1.759TyrAsp: 1.759 ± 0.052	1.419TyrGlu: 1.419 ± 0.043	0.861TyrPhe: 0.861 ± 0.032	2.176TyrGly: 2.176 ± 0.063	0.466TyrHis: 0.466 ± 0.023	0.913TyrIle: 0.913 ± 0.03	0.548TyrLys: 0.548 ± 0.024	2.158TyrLeu: 2.158 ± 0.053	0.397TyrMet: 0.397 ± 0.022	0.613TyrAsn: 0.613 ± 0.027	1.083TyrPro: 1.083 ± 0.033	0.628TyrGln: 0.628 ± 0.03	2.027TyrArg: 2.027 ± 0.056	1.225TyrSer: 1.225 ± 0.046	1.076TyrThr: 1.076 ± 0.04	1.517TyrVal: 1.517 ± 0.041	0.347TyrTrp: 0.347 ± 0.021	0.635TyrTyr: 0.635 ± 0.034	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2656 proteins (856341 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---