Amino acid dipepetide frequency for Amylolactobacillus amylophilus DSM 20533 = JCM 1125

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.018AlaAla: 7.018 ± 0.158
0.283AlaCys: 0.283 ± 0.023
4.646AlaAsp: 4.646 ± 0.103
4.887AlaGlu: 4.887 ± 0.121
2.872AlaPhe: 2.872 ± 0.085
5.866AlaGly: 5.866 ± 0.126
1.504AlaHis: 1.504 ± 0.062
5.895AlaIle: 5.895 ± 0.127
5.486AlaLys: 5.486 ± 0.128
7.414AlaLeu: 7.414 ± 0.138
1.948AlaMet: 1.948 ± 0.069
3.713AlaAsn: 3.713 ± 0.098
2.227AlaPro: 2.227 ± 0.078
3.589AlaGln: 3.589 ± 0.097
3.235AlaArg: 3.235 ± 0.09
4.051AlaSer: 4.051 ± 0.096
4.984AlaThr: 4.984 ± 0.1
5.658AlaVal: 5.658 ± 0.117
0.546AlaTrp: 0.546 ± 0.042
2.249AlaTyr: 2.249 ± 0.071
0.0AlaXaa: 0.0 ± 0.0
Cys
0.25CysAla: 0.25 ± 0.025
0.035CysCys: 0.035 ± 0.009
0.166CysAsp: 0.166 ± 0.019
0.146CysGlu: 0.146 ± 0.016
0.188CysPhe: 0.188 ± 0.017
0.363CysGly: 0.363 ± 0.035
0.088CysHis: 0.088 ± 0.013
0.188CysIle: 0.188 ± 0.019
0.137CysLys: 0.137 ± 0.02
0.325CysLeu: 0.325 ± 0.029
0.069CysMet: 0.069 ± 0.012
0.133CysAsn: 0.133 ± 0.018
0.142CysPro: 0.142 ± 0.018
0.142CysGln: 0.142 ± 0.018
0.117CysArg: 0.117 ± 0.017
0.223CysSer: 0.223 ± 0.022
0.177CysThr: 0.177 ± 0.023
0.195CysVal: 0.195 ± 0.021
0.035CysTrp: 0.035 ± 0.01
0.13CysTyr: 0.13 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
4.124AspAla: 4.124 ± 0.106
0.177AspCys: 0.177 ± 0.022
3.304AspAsp: 3.304 ± 0.101
4.464AspGlu: 4.464 ± 0.111
3.295AspPhe: 3.295 ± 0.091
3.494AspGly: 3.494 ± 0.104
1.205AspHis: 1.205 ± 0.051
3.69AspIle: 3.69 ± 0.09
3.522AspLys: 3.522 ± 0.085
5.703AspLeu: 5.703 ± 0.122
1.287AspMet: 1.287 ± 0.048
2.479AspAsn: 2.479 ± 0.077
2.056AspPro: 2.056 ± 0.065
2.835AspGln: 2.835 ± 0.087
2.178AspArg: 2.178 ± 0.071
3.082AspSer: 3.082 ± 0.077
2.861AspThr: 2.861 ± 0.088
4.077AspVal: 4.077 ± 0.101
0.655AspTrp: 0.655 ± 0.048
2.558AspTyr: 2.558 ± 0.072
0.0AspXaa: 0.0 ± 0.0
Glu
4.314GluAla: 4.314 ± 0.118
0.161GluCys: 0.161 ± 0.018
2.974GluAsp: 2.974 ± 0.088
3.916GluGlu: 3.916 ± 0.115
2.587GluPhe: 2.587 ± 0.08
2.784GluGly: 2.784 ± 0.091
1.539GluHis: 1.539 ± 0.065
4.803GluIle: 4.803 ± 0.122
4.02GluLys: 4.02 ± 0.099
7.264GluLeu: 7.264 ± 0.138
1.751GluMet: 1.751 ± 0.068
3.193GluAsn: 3.193 ± 0.082
2.083GluPro: 2.083 ± 0.067
3.805GluGln: 3.805 ± 0.101
3.118GluArg: 3.118 ± 0.088
3.043GluSer: 3.043 ± 0.087
3.434GluThr: 3.434 ± 0.091
4.243GluVal: 4.243 ± 0.115
0.482GluTrp: 0.482 ± 0.036
2.154GluTyr: 2.154 ± 0.074
0.0GluXaa: 0.0 ± 0.0
Phe
3.491PheAla: 3.491 ± 0.092
0.181PheCys: 0.181 ± 0.024
2.908PheAsp: 2.908 ± 0.076
2.561PheGlu: 2.561 ± 0.078
2.138PhePhe: 2.138 ± 0.086
3.368PheGly: 3.368 ± 0.088
0.785PheHis: 0.785 ± 0.045
3.111PheIle: 3.111 ± 0.099
2.671PheLys: 2.671 ± 0.086
4.265PheLeu: 4.265 ± 0.122
1.099PheMet: 1.099 ± 0.052
2.32PheAsn: 2.32 ± 0.084
1.475PhePro: 1.475 ± 0.061
1.439PheGln: 1.439 ± 0.05
1.57PheArg: 1.57 ± 0.062
3.147PheSer: 3.147 ± 0.107
2.742PheThr: 2.742 ± 0.079
3.394PheVal: 3.394 ± 0.079
0.498PheTrp: 0.498 ± 0.03
1.778PheTyr: 1.778 ± 0.064
0.0PheXaa: 0.0 ± 0.0
Gly
4.851GlyAla: 4.851 ± 0.114
0.261GlyCys: 0.261 ± 0.024
3.191GlyAsp: 3.191 ± 0.084
3.721GlyGlu: 3.721 ± 0.1
3.155GlyPhe: 3.155 ± 0.082
4.212GlyGly: 4.212 ± 0.126
1.36GlyHis: 1.36 ± 0.046
5.32GlyIle: 5.32 ± 0.108
4.436GlyLys: 4.436 ± 0.102
6.598GlyLeu: 6.598 ± 0.13
1.818GlyMet: 1.818 ± 0.074
2.684GlyAsn: 2.684 ± 0.083
1.512GlyPro: 1.512 ± 0.063
3.014GlyGln: 3.014 ± 0.09
2.742GlyArg: 2.742 ± 0.089
3.774GlySer: 3.774 ± 0.098
4.111GlyThr: 4.111 ± 0.114
4.949GlyVal: 4.949 ± 0.118
0.59GlyTrp: 0.59 ± 0.043
2.549GlyTyr: 2.549 ± 0.076
0.0GlyXaa: 0.0 ± 0.0
His
1.435HisAla: 1.435 ± 0.051
0.069HisCys: 0.069 ± 0.012
1.225HisAsp: 1.225 ± 0.05
1.393HisGlu: 1.393 ± 0.063
0.951HisPhe: 0.951 ± 0.049
1.349HisGly: 1.349 ± 0.051
0.555HisHis: 0.555 ± 0.037
1.19HisIle: 1.19 ± 0.058
0.918HisLys: 0.918 ± 0.045
1.888HisLeu: 1.888 ± 0.065
0.425HisMet: 0.425 ± 0.029
0.935HisAsn: 0.935 ± 0.041
0.946HisPro: 0.946 ± 0.047
0.9HisGln: 0.9 ± 0.043
0.882HisArg: 0.882 ± 0.047
0.946HisSer: 0.946 ± 0.047
1.015HisThr: 1.015 ± 0.048
1.444HisVal: 1.444 ± 0.064
0.177HisTrp: 0.177 ± 0.016
0.849HisTyr: 0.849 ± 0.047
0.0HisXaa: 0.0 ± 0.0
Ile
6.034IleAla: 6.034 ± 0.13
0.27IleCys: 0.27 ± 0.021
4.394IleAsp: 4.394 ± 0.105
4.363IleGlu: 4.363 ± 0.098
3.498IlePhe: 3.498 ± 0.107
5.201IleGly: 5.201 ± 0.112
1.17IleHis: 1.17 ± 0.049
5.524IleIle: 5.524 ± 0.108
4.971IleLys: 4.971 ± 0.11
6.844IleLeu: 6.844 ± 0.142
1.787IleMet: 1.787 ± 0.059
3.823IleAsn: 3.823 ± 0.092
2.802IlePro: 2.802 ± 0.085
2.315IleGln: 2.315 ± 0.079
2.775IleArg: 2.775 ± 0.073
4.767IleSer: 4.767 ± 0.114
4.624IleThr: 4.624 ± 0.092
5.451IleVal: 5.451 ± 0.136
0.661IleTrp: 0.661 ± 0.036
2.395IleTyr: 2.395 ± 0.065
0.0IleXaa: 0.0 ± 0.0
Lys
4.155LysAla: 4.155 ± 0.093
0.133LysCys: 0.133 ± 0.017
3.507LysAsp: 3.507 ± 0.09
4.305LysGlu: 4.305 ± 0.115
2.373LysPhe: 2.373 ± 0.081
3.129LysGly: 3.129 ± 0.096
1.13LysHis: 1.13 ± 0.047
4.988LysIle: 4.988 ± 0.109
5.267LysLys: 5.267 ± 0.134
6.326LysLeu: 6.326 ± 0.131
2.096LysMet: 2.096 ± 0.064
3.631LysAsn: 3.631 ± 0.09
2.056LysPro: 2.056 ± 0.073
3.277LysGln: 3.277 ± 0.082
3.151LysArg: 3.151 ± 0.091
3.839LysSer: 3.839 ± 0.098
3.98LysThr: 3.98 ± 0.098
4.409LysVal: 4.409 ± 0.109
0.555LysTrp: 0.555 ± 0.039
2.614LysTyr: 2.614 ± 0.077
0.0LysXaa: 0.0 ± 0.0
Leu
8.931LeuAla: 8.931 ± 0.141
0.338LeuCys: 0.338 ± 0.025
5.577LeuAsp: 5.577 ± 0.131
5.371LeuGlu: 5.371 ± 0.125
4.29LeuPhe: 4.29 ± 0.128
6.43LeuGly: 6.43 ± 0.117
1.734LeuHis: 1.734 ± 0.058
7.377LeuIle: 7.377 ± 0.161
6.006LeuLys: 6.006 ± 0.123
9.577LeuLeu: 9.577 ± 0.213
2.255LeuMet: 2.255 ± 0.075
5.221LeuAsn: 5.221 ± 0.12
4.073LeuPro: 4.073 ± 0.095
3.938LeuGln: 3.938 ± 0.092
3.909LeuArg: 3.909 ± 0.109
6.224LeuSer: 6.224 ± 0.129
6.93LeuThr: 6.93 ± 0.126
7.589LeuVal: 7.589 ± 0.146
0.712LeuTrp: 0.712 ± 0.038
2.733LeuTyr: 2.733 ± 0.075
0.0LeuXaa: 0.0 ± 0.0
Met
2.26MetAla: 2.26 ± 0.073
0.091MetCys: 0.091 ± 0.014
1.424MetAsp: 1.424 ± 0.053
1.336MetGlu: 1.336 ± 0.046
0.896MetPhe: 0.896 ± 0.045
1.583MetGly: 1.583 ± 0.063
0.431MetHis: 0.431 ± 0.026
1.93MetIle: 1.93 ± 0.069
1.765MetLys: 1.765 ± 0.058
2.297MetLeu: 2.297 ± 0.077
0.758MetMet: 0.758 ± 0.042
1.417MetAsn: 1.417 ± 0.062
0.913MetPro: 0.913 ± 0.042
1.249MetGln: 1.249 ± 0.052
1.057MetArg: 1.057 ± 0.051
1.473MetSer: 1.473 ± 0.056
1.784MetThr: 1.784 ± 0.065
1.762MetVal: 1.762 ± 0.074
0.159MetTrp: 0.159 ± 0.019
0.621MetTyr: 0.621 ± 0.031
0.0MetXaa: 0.0 ± 0.0
Asn
3.354AsnAla: 3.354 ± 0.101
0.199AsnCys: 0.199 ± 0.022
2.773AsnAsp: 2.773 ± 0.079
3.215AsnGlu: 3.215 ± 0.089
2.344AsnPhe: 2.344 ± 0.069
3.372AsnGly: 3.372 ± 0.099
1.07AsnHis: 1.07 ± 0.05
3.401AsnIle: 3.401 ± 0.092
3.328AsnLys: 3.328 ± 0.079
4.796AsnLeu: 4.796 ± 0.102
1.305AsnMet: 1.305 ± 0.047
2.62AsnAsn: 2.62 ± 0.084
2.386AsnPro: 2.386 ± 0.084
2.598AsnGln: 2.598 ± 0.098
2.063AsnArg: 2.063 ± 0.072
2.868AsnSer: 2.868 ± 0.084
2.563AsnThr: 2.563 ± 0.08
3.317AsnVal: 3.317 ± 0.096
0.546AsnTrp: 0.546 ± 0.04
2.019AsnTyr: 2.019 ± 0.071
0.0AsnXaa: 0.0 ± 0.0
Pro
2.956ProAla: 2.956 ± 0.088
0.102ProCys: 0.102 ± 0.016
2.275ProAsp: 2.275 ± 0.075
2.95ProGlu: 2.95 ± 0.086
1.692ProPhe: 1.692 ± 0.065
2.291ProGly: 2.291 ± 0.076
0.577ProHis: 0.577 ± 0.034
2.549ProIle: 2.549 ± 0.09
2.118ProLys: 2.118 ± 0.067
3.206ProLeu: 3.206 ± 0.086
0.648ProMet: 0.648 ± 0.036
1.758ProAsn: 1.758 ± 0.067
0.65ProPro: 0.65 ± 0.035
1.369ProGln: 1.369 ± 0.063
1.203ProArg: 1.203 ± 0.048
1.815ProSer: 1.815 ± 0.064
2.415ProThr: 2.415 ± 0.078
2.815ProVal: 2.815 ± 0.081
0.268ProTrp: 0.268 ± 0.025
1.205ProTyr: 1.205 ± 0.061
0.0ProXaa: 0.0 ± 0.0
Gln
3.376GlnAla: 3.376 ± 0.099
0.088GlnCys: 0.088 ± 0.014
2.211GlnAsp: 2.211 ± 0.068
2.797GlnGlu: 2.797 ± 0.081
1.924GlnPhe: 1.924 ± 0.067
2.037GlnGly: 2.037 ± 0.061
0.803GlnHis: 0.803 ± 0.047
3.706GlnIle: 3.706 ± 0.098
3.235GlnLys: 3.235 ± 0.094
5.039GlnLeu: 5.039 ± 0.117
1.313GlnMet: 1.313 ± 0.05
2.527GlnAsn: 2.527 ± 0.078
1.395GlnPro: 1.395 ± 0.065
2.479GlnGln: 2.479 ± 0.09
1.897GlnArg: 1.897 ± 0.068
2.412GlnSer: 2.412 ± 0.074
2.813GlnThr: 2.813 ± 0.087
3.147GlnVal: 3.147 ± 0.079
0.323GlnTrp: 0.323 ± 0.03
1.409GlnTyr: 1.409 ± 0.061
0.0GlnXaa: 0.0 ± 0.0
Arg
3.071ArgAla: 3.071 ± 0.09
0.108ArgCys: 0.108 ± 0.017
2.333ArgAsp: 2.333 ± 0.064
2.645ArgGlu: 2.645 ± 0.078
1.902ArgPhe: 1.902 ± 0.064
2.459ArgGly: 2.459 ± 0.087
0.865ArgHis: 0.865 ± 0.045
3.124ArgIle: 3.124 ± 0.085
2.669ArgLys: 2.669 ± 0.082
4.1ArgLeu: 4.1 ± 0.102
1.11ArgMet: 1.11 ± 0.052
2.021ArgAsn: 2.021 ± 0.068
1.49ArgPro: 1.49 ± 0.056
2.238ArgGln: 2.238 ± 0.074
2.335ArgArg: 2.335 ± 0.075
2.085ArgSer: 2.085 ± 0.07
2.255ArgThr: 2.255 ± 0.06
2.965ArgVal: 2.965 ± 0.085
0.345ArgTrp: 0.345 ± 0.03
1.596ArgTyr: 1.596 ± 0.064
0.0ArgXaa: 0.0 ± 0.0
Ser
4.347SerAla: 4.347 ± 0.092
0.175SerCys: 0.175 ± 0.019
3.288SerAsp: 3.288 ± 0.095
3.301SerGlu: 3.301 ± 0.094
3.027SerPhe: 3.027 ± 0.081
4.484SerGly: 4.484 ± 0.102
1.086SerHis: 1.086 ± 0.049
4.157SerIle: 4.157 ± 0.105
3.509SerLys: 3.509 ± 0.101
5.791SerLeu: 5.791 ± 0.122
1.526SerMet: 1.526 ± 0.058
2.729SerAsn: 2.729 ± 0.088
1.687SerPro: 1.687 ± 0.067
2.24SerGln: 2.24 ± 0.078
2.415SerArg: 2.415 ± 0.08
3.702SerSer: 3.702 ± 0.125
3.491SerThr: 3.491 ± 0.088
4.153SerVal: 4.153 ± 0.094
0.59SerTrp: 0.59 ± 0.038
2.32SerTyr: 2.32 ± 0.071
0.0SerXaa: 0.0 ± 0.0
Thr
4.865ThrAla: 4.865 ± 0.103
0.155ThrCys: 0.155 ± 0.02
3.746ThrAsp: 3.746 ± 0.097
3.637ThrGlu: 3.637 ± 0.107
2.576ThrPhe: 2.576 ± 0.079
4.48ThrGly: 4.48 ± 0.108
1.198ThrHis: 1.198 ± 0.05
4.657ThrIle: 4.657 ± 0.109
4.305ThrLys: 4.305 ± 0.103
5.528ThrLeu: 5.528 ± 0.119
1.338ThrMet: 1.338 ± 0.057
3.242ThrAsn: 3.242 ± 0.093
2.592ThrPro: 2.592 ± 0.093
2.07ThrGln: 2.07 ± 0.068
2.233ThrArg: 2.233 ± 0.079
3.52ThrSer: 3.52 ± 0.083
4.157ThrThr: 4.157 ± 0.101
4.712ThrVal: 4.712 ± 0.116
0.491ThrTrp: 0.491 ± 0.035
1.988ThrTyr: 1.988 ± 0.077
0.0ThrXaa: 0.0 ± 0.0
Val
6.315ValAla: 6.315 ± 0.121
0.239ValCys: 0.239 ± 0.023
4.449ValAsp: 4.449 ± 0.1
4.228ValGlu: 4.228 ± 0.095
2.87ValPhe: 2.87 ± 0.08
5.008ValGly: 5.008 ± 0.117
1.234ValHis: 1.234 ± 0.059
5.382ValIle: 5.382 ± 0.138
4.584ValLys: 4.584 ± 0.112
7.06ValLeu: 7.06 ± 0.147
1.762ValMet: 1.762 ± 0.064
3.6ValAsn: 3.6 ± 0.095
2.791ValPro: 2.791 ± 0.087
2.824ValGln: 2.824 ± 0.085
2.7ValArg: 2.7 ± 0.075
4.411ValSer: 4.411 ± 0.103
4.849ValThr: 4.849 ± 0.108
5.698ValVal: 5.698 ± 0.135
0.548ValTrp: 0.548 ± 0.039
2.16ValTyr: 2.16 ± 0.074
0.0ValXaa: 0.0 ± 0.0
Trp
0.528TrpAla: 0.528 ± 0.036
0.033TrpCys: 0.033 ± 0.009
0.413TrpAsp: 0.413 ± 0.029
0.329TrpGlu: 0.329 ± 0.032
0.471TrpPhe: 0.471 ± 0.032
0.506TrpGly: 0.506 ± 0.034
0.283TrpHis: 0.283 ± 0.023
0.612TrpIle: 0.612 ± 0.038
0.413TrpLys: 0.413 ± 0.035
1.13TrpLeu: 1.13 ± 0.054
0.206TrpMet: 0.206 ± 0.025
0.48TrpAsn: 0.48 ± 0.035
0.296TrpPro: 0.296 ± 0.026
0.593TrpGln: 0.593 ± 0.038
0.407TrpArg: 0.407 ± 0.032
0.537TrpSer: 0.537 ± 0.035
0.442TrpThr: 0.442 ± 0.029
0.515TrpVal: 0.515 ± 0.033
0.15TrpTrp: 0.15 ± 0.018
0.338TrpTyr: 0.338 ± 0.033
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.393TyrAla: 2.393 ± 0.08
0.15TyrCys: 0.15 ± 0.019
2.244TyrAsp: 2.244 ± 0.071
2.105TyrGlu: 2.105 ± 0.068
1.893TyrPhe: 1.893 ± 0.073
2.435TyrGly: 2.435 ± 0.075
0.876TyrHis: 0.876 ± 0.04
2.061TyrIle: 2.061 ± 0.078
1.561TyrLys: 1.561 ± 0.062
4.062TyrLeu: 4.062 ± 0.096
0.705TyrMet: 0.705 ± 0.038
1.612TyrAsn: 1.612 ± 0.067
1.289TyrPro: 1.289 ± 0.051
2.019TyrGln: 2.019 ± 0.068
1.729TyrArg: 1.729 ± 0.062
2.096TyrSer: 2.096 ± 0.077
1.862TyrThr: 1.862 ± 0.066
2.22TyrVal: 2.22 ± 0.061
0.354TyrTrp: 0.354 ± 0.029
1.464TyrTyr: 1.464 ± 0.061
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1532 proteins (452247 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski