Amino acid dipepetide frequency for Tindallia californiensis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.477AlaAla: 5.477 ± 0.112
0.729AlaCys: 0.729 ± 0.03
3.317AlaAsp: 3.317 ± 0.065
4.979AlaGlu: 4.979 ± 0.085
3.061AlaPhe: 3.061 ± 0.071
5.466AlaGly: 5.466 ± 0.098
1.248AlaHis: 1.248 ± 0.041
5.613AlaIle: 5.613 ± 0.084
4.1AlaLys: 4.1 ± 0.082
7.349AlaLeu: 7.349 ± 0.091
2.516AlaMet: 2.516 ± 0.057
2.5AlaAsn: 2.5 ± 0.049
2.032AlaPro: 2.032 ± 0.058
2.158AlaGln: 2.158 ± 0.053
2.656AlaArg: 2.656 ± 0.052
4.277AlaSer: 4.277 ± 0.078
3.523AlaThr: 3.523 ± 0.074
5.135AlaVal: 5.135 ± 0.088
0.527AlaTrp: 0.527 ± 0.028
2.377AlaTyr: 2.377 ± 0.05
0.0AlaXaa: 0.0 ± 0.0
Cys
0.522CysAla: 0.522 ± 0.023
0.138CysCys: 0.138 ± 0.014
0.493CysAsp: 0.493 ± 0.025
0.513CysGlu: 0.513 ± 0.026
0.401CysPhe: 0.401 ± 0.022
0.921CysGly: 0.921 ± 0.038
0.278CysHis: 0.278 ± 0.018
0.623CysIle: 0.623 ± 0.028
0.486CysLys: 0.486 ± 0.026
0.842CysLeu: 0.842 ± 0.031
0.237CysMet: 0.237 ± 0.017
0.339CysAsn: 0.339 ± 0.019
0.483CysPro: 0.483 ± 0.03
0.444CysGln: 0.444 ± 0.022
0.519CysArg: 0.519 ± 0.023
0.608CysSer: 0.608 ± 0.028
0.442CysThr: 0.442 ± 0.023
0.585CysVal: 0.585 ± 0.026
0.078CysTrp: 0.078 ± 0.008
0.327CysTyr: 0.327 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
3.275AspAla: 3.275 ± 0.064
0.47AspCys: 0.47 ± 0.023
2.38AspAsp: 2.38 ± 0.06
4.293AspGlu: 4.293 ± 0.08
2.462AspPhe: 2.462 ± 0.066
3.413AspGly: 3.413 ± 0.079
1.377AspHis: 1.377 ± 0.041
4.232AspIle: 4.232 ± 0.073
2.779AspLys: 2.779 ± 0.068
5.096AspLeu: 5.096 ± 0.071
1.505AspMet: 1.505 ± 0.037
1.68AspAsn: 1.68 ± 0.05
2.19AspPro: 2.19 ± 0.06
2.272AspGln: 2.272 ± 0.046
2.448AspArg: 2.448 ± 0.054
2.793AspSer: 2.793 ± 0.057
2.409AspThr: 2.409 ± 0.063
3.409AspVal: 3.409 ± 0.063
0.525AspTrp: 0.525 ± 0.03
2.091AspTyr: 2.091 ± 0.052
0.0AspXaa: 0.0 ± 0.0
Glu
6.305GluAla: 6.305 ± 0.098
0.512GluCys: 0.512 ± 0.029
4.148GluAsp: 4.148 ± 0.076
8.545GluGlu: 8.545 ± 0.145
2.211GluPhe: 2.211 ± 0.053
4.999GluGly: 4.999 ± 0.079
1.314GluHis: 1.314 ± 0.042
6.546GluIle: 6.546 ± 0.086
8.124GluLys: 8.124 ± 0.133
6.778GluLeu: 6.778 ± 0.103
3.008GluMet: 3.008 ± 0.068
4.076GluAsn: 4.076 ± 0.064
2.184GluPro: 2.184 ± 0.059
2.62GluGln: 2.62 ± 0.061
3.393GluArg: 3.393 ± 0.069
4.351GluSer: 4.351 ± 0.068
4.337GluThr: 4.337 ± 0.079
5.446GluVal: 5.446 ± 0.081
0.749GluTrp: 0.749 ± 0.03
2.412GluTyr: 2.412 ± 0.052
0.0GluXaa: 0.0 ± 0.0
Phe
2.52PheAla: 2.52 ± 0.059
0.469PheCys: 0.469 ± 0.024
2.265PheAsp: 2.265 ± 0.052
2.581PheGlu: 2.581 ± 0.048
2.176PhePhe: 2.176 ± 0.062
2.776PheGly: 2.776 ± 0.07
1.004PheHis: 1.004 ± 0.033
2.994PheIle: 2.994 ± 0.068
1.825PheLys: 1.825 ± 0.047
4.089PheLeu: 4.089 ± 0.082
1.266PheMet: 1.266 ± 0.039
1.6PheAsn: 1.6 ± 0.044
1.492PhePro: 1.492 ± 0.046
1.708PheGln: 1.708 ± 0.046
1.732PheArg: 1.732 ± 0.047
2.956PheSer: 2.956 ± 0.067
2.167PheThr: 2.167 ± 0.053
2.552PheVal: 2.552 ± 0.06
0.401PheTrp: 0.401 ± 0.026
1.529PheTyr: 1.529 ± 0.044
0.0PheXaa: 0.0 ± 0.0
Gly
4.744GlyAla: 4.744 ± 0.086
0.865GlyCys: 0.865 ± 0.034
3.282GlyAsp: 3.282 ± 0.065
4.738GlyGlu: 4.738 ± 0.086
3.276GlyPhe: 3.276 ± 0.076
4.926GlyGly: 4.926 ± 0.094
1.473GlyHis: 1.473 ± 0.039
6.507GlyIle: 6.507 ± 0.1
4.925GlyLys: 4.925 ± 0.076
6.346GlyLeu: 6.346 ± 0.098
2.468GlyMet: 2.468 ± 0.059
2.831GlyAsn: 2.831 ± 0.065
1.611GlyPro: 1.611 ± 0.044
2.078GlyGln: 2.078 ± 0.048
2.736GlyArg: 2.736 ± 0.062
4.102GlySer: 4.102 ± 0.072
3.796GlyThr: 3.796 ± 0.064
4.94GlyVal: 4.94 ± 0.086
0.703GlyTrp: 0.703 ± 0.031
2.716GlyTyr: 2.716 ± 0.053
0.0GlyXaa: 0.0 ± 0.0
His
1.204HisAla: 1.204 ± 0.036
0.272HisCys: 0.272 ± 0.018
0.941HisAsp: 0.941 ± 0.032
1.294HisGlu: 1.294 ± 0.039
1.033HisPhe: 1.033 ± 0.036
1.347HisGly: 1.347 ± 0.04
0.799HisHis: 0.799 ± 0.03
1.556HisIle: 1.556 ± 0.045
1.021HisLys: 1.021 ± 0.039
2.295HisLeu: 2.295 ± 0.06
0.593HisMet: 0.593 ± 0.022
0.714HisAsn: 0.714 ± 0.026
1.206HisPro: 1.206 ± 0.041
1.332HisGln: 1.332 ± 0.04
1.166HisArg: 1.166 ± 0.034
1.309HisSer: 1.309 ± 0.041
1.055HisThr: 1.055 ± 0.033
1.275HisVal: 1.275 ± 0.039
0.26HisTrp: 0.26 ± 0.017
0.998HisTyr: 0.998 ± 0.038
0.0HisXaa: 0.0 ± 0.0
Ile
5.893IleAla: 5.893 ± 0.093
0.736IleCys: 0.736 ± 0.027
4.541IleAsp: 4.541 ± 0.069
6.178IleGlu: 6.178 ± 0.104
3.033IlePhe: 3.033 ± 0.065
5.733IleGly: 5.733 ± 0.093
1.812IleHis: 1.812 ± 0.042
5.823IleIle: 5.823 ± 0.105
4.773IleLys: 4.773 ± 0.076
7.429IleLeu: 7.429 ± 0.105
2.182IleMet: 2.182 ± 0.055
3.518IleAsn: 3.518 ± 0.065
3.515IlePro: 3.515 ± 0.065
3.186IleGln: 3.186 ± 0.061
3.728IleArg: 3.728 ± 0.072
5.259IleSer: 5.259 ± 0.079
4.41IleThr: 4.41 ± 0.075
4.846IleVal: 4.846 ± 0.077
0.559IleTrp: 0.559 ± 0.029
2.32IleTyr: 2.32 ± 0.05
0.0IleXaa: 0.0 ± 0.0
Lys
4.939LysAla: 4.939 ± 0.084
0.513LysCys: 0.513 ± 0.03
3.773LysAsp: 3.773 ± 0.068
7.276LysGlu: 7.276 ± 0.124
1.382LysPhe: 1.382 ± 0.041
4.422LysGly: 4.422 ± 0.074
1.333LysHis: 1.333 ± 0.042
5.217LysIle: 5.217 ± 0.079
6.46LysLys: 6.46 ± 0.111
5.099LysLeu: 5.099 ± 0.09
2.401LysMet: 2.401 ± 0.055
3.539LysAsn: 3.539 ± 0.072
2.259LysPro: 2.259 ± 0.054
2.462LysGln: 2.462 ± 0.058
3.07LysArg: 3.07 ± 0.059
3.636LysSer: 3.636 ± 0.06
3.692LysThr: 3.692 ± 0.069
4.314LysVal: 4.314 ± 0.084
0.599LysTrp: 0.599 ± 0.028
1.883LysTyr: 1.883 ± 0.044
0.0LysXaa: 0.0 ± 0.0
Leu
6.701LeuAla: 6.701 ± 0.103
0.821LeuCys: 0.821 ± 0.035
4.649LeuAsp: 4.649 ± 0.079
8.061LeuGlu: 8.061 ± 0.117
3.982LeuPhe: 3.982 ± 0.079
6.423LeuGly: 6.423 ± 0.089
1.744LeuHis: 1.744 ± 0.047
7.006LeuIle: 7.006 ± 0.098
6.803LeuLys: 6.803 ± 0.099
9.754LeuLeu: 9.754 ± 0.147
3.256LeuMet: 3.256 ± 0.062
3.787LeuAsn: 3.787 ± 0.062
3.593LeuPro: 3.593 ± 0.07
3.443LeuGln: 3.443 ± 0.072
4.267LeuArg: 4.267 ± 0.069
6.431LeuSer: 6.431 ± 0.096
5.055LeuThr: 5.055 ± 0.074
6.184LeuVal: 6.184 ± 0.089
0.759LeuTrp: 0.759 ± 0.03
2.917LeuTyr: 2.917 ± 0.063
0.0LeuXaa: 0.0 ± 0.0
Met
2.648MetAla: 2.648 ± 0.056
0.156MetCys: 0.156 ± 0.013
2.024MetAsp: 2.024 ± 0.048
2.865MetGlu: 2.865 ± 0.057
0.881MetPhe: 0.881 ± 0.031
2.235MetGly: 2.235 ± 0.049
0.517MetHis: 0.517 ± 0.024
2.94MetIle: 2.94 ± 0.058
2.825MetLys: 2.825 ± 0.06
2.846MetLeu: 2.846 ± 0.058
1.252MetMet: 1.252 ± 0.037
1.693MetAsn: 1.693 ± 0.044
1.256MetPro: 1.256 ± 0.04
0.981MetGln: 0.981 ± 0.029
1.115MetArg: 1.115 ± 0.036
1.655MetSer: 1.655 ± 0.044
1.871MetThr: 1.871 ± 0.047
2.442MetVal: 2.442 ± 0.058
0.164MetTrp: 0.164 ± 0.011
0.692MetTyr: 0.692 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
2.772AsnAla: 2.772 ± 0.059
0.384AsnCys: 0.384 ± 0.022
1.895AsnAsp: 1.895 ± 0.044
3.022AsnGlu: 3.022 ± 0.067
1.429AsnPhe: 1.429 ± 0.044
2.635AsnGly: 2.635 ± 0.055
1.232AsnHis: 1.232 ± 0.037
3.385AsnIle: 3.385 ± 0.073
2.669AsnLys: 2.669 ± 0.064
3.998AsnLeu: 3.998 ± 0.064
1.305AsnMet: 1.305 ± 0.033
1.765AsnAsn: 1.765 ± 0.046
2.131AsnPro: 2.131 ± 0.05
2.176AsnGln: 2.176 ± 0.057
2.333AsnArg: 2.333 ± 0.062
2.1AsnSer: 2.1 ± 0.056
2.072AsnThr: 2.072 ± 0.047
2.489AsnVal: 2.489 ± 0.058
0.396AsnTrp: 0.396 ± 0.022
1.44AsnTyr: 1.44 ± 0.042
0.0AsnXaa: 0.0 ± 0.0
Pro
2.356ProAla: 2.356 ± 0.058
0.295ProCys: 0.295 ± 0.019
2.044ProAsp: 2.044 ± 0.053
3.707ProGlu: 3.707 ± 0.069
1.617ProPhe: 1.617 ± 0.05
2.588ProGly: 2.588 ± 0.054
0.768ProHis: 0.768 ± 0.032
2.58ProIle: 2.58 ± 0.056
1.841ProLys: 1.841 ± 0.045
3.405ProLeu: 3.405 ± 0.069
1.076ProMet: 1.076 ± 0.035
1.223ProAsn: 1.223 ± 0.038
1.122ProPro: 1.122 ± 0.04
1.162ProGln: 1.162 ± 0.033
1.214ProArg: 1.214 ± 0.041
2.229ProSer: 2.229 ± 0.052
1.753ProThr: 1.753 ± 0.051
3.187ProVal: 3.187 ± 0.061
0.357ProTrp: 0.357 ± 0.02
1.442ProTyr: 1.442 ± 0.042
0.0ProXaa: 0.0 ± 0.0
Gln
2.513GlnAla: 2.513 ± 0.052
0.319GlnCys: 0.319 ± 0.018
1.688GlnAsp: 1.688 ± 0.041
3.592GlnGlu: 3.592 ± 0.073
1.255GlnPhe: 1.255 ± 0.039
2.298GlnGly: 2.298 ± 0.044
0.871GlnHis: 0.871 ± 0.032
2.706GlnIle: 2.706 ± 0.053
3.12GlnLys: 3.12 ± 0.07
3.67GlnLeu: 3.67 ± 0.068
1.285GlnMet: 1.285 ± 0.036
1.583GlnAsn: 1.583 ± 0.039
1.237GlnPro: 1.237 ± 0.038
2.101GlnGln: 2.101 ± 0.062
1.962GlnArg: 1.962 ± 0.053
2.002GlnSer: 2.002 ± 0.052
1.655GlnThr: 1.655 ± 0.048
2.585GlnVal: 2.585 ± 0.054
0.481GlnTrp: 0.481 ± 0.024
1.311GlnTyr: 1.311 ± 0.039
0.0GlnXaa: 0.0 ± 0.0
Arg
2.367ArgAla: 2.367 ± 0.049
0.422ArgCys: 0.422 ± 0.02
2.056ArgAsp: 2.056 ± 0.05
3.856ArgGlu: 3.856 ± 0.076
1.841ArgPhe: 1.841 ± 0.052
2.523ArgGly: 2.523 ± 0.054
0.925ArgHis: 0.925 ± 0.035
3.835ArgIle: 3.835 ± 0.066
3.587ArgLys: 3.587 ± 0.065
4.093ArgLeu: 4.093 ± 0.06
1.595ArgMet: 1.595 ± 0.04
2.186ArgAsn: 2.186 ± 0.053
1.334ArgPro: 1.334 ± 0.045
1.926ArgGln: 1.926 ± 0.057
2.094ArgArg: 2.094 ± 0.053
2.449ArgSer: 2.449 ± 0.048
1.866ArgThr: 1.866 ± 0.048
2.898ArgVal: 2.898 ± 0.066
0.478ArgTrp: 0.478 ± 0.023
1.743ArgTyr: 1.743 ± 0.044
0.0ArgXaa: 0.0 ± 0.0
Ser
3.539SerAla: 3.539 ± 0.069
0.576SerCys: 0.576 ± 0.028
2.854SerAsp: 2.854 ± 0.068
4.183SerGlu: 4.183 ± 0.071
3.037SerPhe: 3.037 ± 0.064
4.527SerGly: 4.527 ± 0.08
1.34SerHis: 1.34 ± 0.035
5.063SerIle: 5.063 ± 0.09
3.643SerLys: 3.643 ± 0.069
6.346SerLeu: 6.346 ± 0.103
2.069SerMet: 2.069 ± 0.054
2.284SerAsn: 2.284 ± 0.05
2.089SerPro: 2.089 ± 0.05
2.29SerGln: 2.29 ± 0.054
2.707SerArg: 2.707 ± 0.051
3.659SerSer: 3.659 ± 0.072
2.779SerThr: 2.779 ± 0.046
4.144SerVal: 4.144 ± 0.075
0.529SerTrp: 0.529 ± 0.027
1.959SerTyr: 1.959 ± 0.049
0.0SerXaa: 0.0 ± 0.0
Thr
3.728ThrAla: 3.728 ± 0.069
0.497ThrCys: 0.497 ± 0.026
2.642ThrAsp: 2.642 ± 0.054
3.876ThrGlu: 3.876 ± 0.06
2.147ThrPhe: 2.147 ± 0.057
4.473ThrGly: 4.473 ± 0.075
1.083ThrHis: 1.083 ± 0.038
4.222ThrIle: 4.222 ± 0.089
2.775ThrLys: 2.775 ± 0.06
5.181ThrLeu: 5.181 ± 0.08
1.519ThrMet: 1.519 ± 0.042
1.96ThrAsn: 1.96 ± 0.056
2.186ThrPro: 2.186 ± 0.049
1.427ThrGln: 1.427 ± 0.038
2.035ThrArg: 2.035 ± 0.046
3.088ThrSer: 3.088 ± 0.057
2.644ThrThr: 2.644 ± 0.059
3.778ThrVal: 3.778 ± 0.072
0.374ThrTrp: 0.374 ± 0.02
1.663ThrTyr: 1.663 ± 0.048
0.0ThrXaa: 0.0 ± 0.0
Val
4.952ValAla: 4.952 ± 0.09
0.645ValCys: 0.645 ± 0.03
3.705ValAsp: 3.705 ± 0.079
5.263ValGlu: 5.263 ± 0.083
2.971ValPhe: 2.971 ± 0.057
4.449ValGly: 4.449 ± 0.081
1.295ValHis: 1.295 ± 0.036
5.458ValIle: 5.458 ± 0.089
4.219ValLys: 4.219 ± 0.076
6.748ValLeu: 6.748 ± 0.096
2.323ValMet: 2.323 ± 0.051
2.728ValAsn: 2.728 ± 0.054
2.397ValPro: 2.397 ± 0.061
2.155ValGln: 2.155 ± 0.054
2.608ValArg: 2.608 ± 0.05
4.34ValSer: 4.34 ± 0.069
3.761ValThr: 3.761 ± 0.074
5.025ValVal: 5.025 ± 0.093
0.52ValTrp: 0.52 ± 0.023
2.184ValTyr: 2.184 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
0.495TrpAla: 0.495 ± 0.022
0.079TrpCys: 0.079 ± 0.009
0.454TrpAsp: 0.454 ± 0.022
0.711TrpGlu: 0.711 ± 0.028
0.375TrpPhe: 0.375 ± 0.019
0.517TrpGly: 0.517 ± 0.027
0.198TrpHis: 0.198 ± 0.013
0.881TrpIle: 0.881 ± 0.03
0.692TrpLys: 0.692 ± 0.028
0.879TrpLeu: 0.879 ± 0.028
0.325TrpMet: 0.325 ± 0.018
0.438TrpAsn: 0.438 ± 0.024
0.243TrpPro: 0.243 ± 0.019
0.374TrpGln: 0.374 ± 0.019
0.356TrpArg: 0.356 ± 0.019
0.484TrpSer: 0.484 ± 0.023
0.418TrpThr: 0.418 ± 0.02
0.571TrpVal: 0.571 ± 0.023
0.103TrpTrp: 0.103 ± 0.011
0.29TrpTyr: 0.29 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.09TyrAla: 2.09 ± 0.049
0.38TyrCys: 0.38 ± 0.019
1.948TyrAsp: 1.948 ± 0.046
2.526TyrGlu: 2.526 ± 0.052
1.532TyrPhe: 1.532 ± 0.047
2.392TyrGly: 2.392 ± 0.049
1.057TyrHis: 1.057 ± 0.037
2.288TyrIle: 2.288 ± 0.053
1.603TyrLys: 1.603 ± 0.042
3.396TyrLeu: 3.396 ± 0.064
0.878TyrMet: 0.878 ± 0.032
1.183TyrAsn: 1.183 ± 0.034
1.406TyrPro: 1.406 ± 0.035
1.941TyrGln: 1.941 ± 0.048
1.933TyrArg: 1.933 ± 0.046
1.89TyrSer: 1.89 ± 0.053
1.593TyrThr: 1.593 ± 0.041
1.937TyrVal: 1.937 ± 0.044
0.32TyrTrp: 0.32 ± 0.021
1.505TyrTyr: 1.505 ± 0.053
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2832 proteins (931524 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski