Amino acid dipepetide frequency for Sulfurimonas sp. UBA12504

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.22AlaAla: 5.22 ± 0.126	0.697AlaCys: 0.697 ± 0.038	3.527AlaAsp: 3.527 ± 0.087	3.804AlaGlu: 3.804 ± 0.081	4.082AlaPhe: 4.082 ± 0.103	4.057AlaGly: 4.057 ± 0.104	1.687AlaHis: 1.687 ± 0.055	6.134AlaIle: 6.134 ± 0.101	6.267AlaLys: 6.267 ± 0.104	8.409AlaLeu: 8.409 ± 0.125	2.146AlaMet: 2.146 ± 0.068	3.532AlaAsn: 3.532 ± 0.073	1.986AlaPro: 1.986 ± 0.06	2.891AlaGln: 2.891 ± 0.076	2.356AlaArg: 2.356 ± 0.069	4.76AlaSer: 4.76 ± 0.103	3.994AlaThr: 3.994 ± 0.076	4.182AlaVal: 4.182 ± 0.099	0.523AlaTrp: 0.523 ± 0.029	2.826AlaTyr: 2.826 ± 0.063	0.025AlaXaa: 0.025 ± 0.007
Cys	0.653CysAla: 0.653 ± 0.03	0.088CysCys: 0.088 ± 0.012	0.65CysAsp: 0.65 ± 0.034	0.813CysGlu: 0.813 ± 0.04	0.367CysPhe: 0.367 ± 0.023	0.736CysGly: 0.736 ± 0.032	0.271CysHis: 0.271 ± 0.027	0.537CysIle: 0.537 ± 0.035	0.692CysLys: 0.692 ± 0.037	0.518CysLeu: 0.518 ± 0.029	0.213CysMet: 0.213 ± 0.019	0.453CysAsn: 0.453 ± 0.028	0.381CysPro: 0.381 ± 0.028	0.263CysGln: 0.263 ± 0.021	0.309CysArg: 0.309 ± 0.021	0.677CysSer: 0.677 ± 0.031	0.381CysThr: 0.381 ± 0.028	0.597CysVal: 0.597 ± 0.031	0.052CysTrp: 0.052 ± 0.009	0.329CysTyr: 0.329 ± 0.025	0.003CysXaa: 0.003 ± 0.002
Asp	4.896AspAla: 4.896 ± 0.092	0.429AspCys: 0.429 ± 0.029	2.717AspAsp: 2.717 ± 0.091	4.78AspGlu: 4.78 ± 0.094	3.223AspPhe: 3.223 ± 0.062	3.479AspGly: 3.479 ± 0.091	0.641AspHis: 0.641 ± 0.04	5.261AspIle: 5.261 ± 0.096	4.235AspLys: 4.235 ± 0.092	4.799AspLeu: 4.799 ± 0.1	1.645AspMet: 1.645 ± 0.052	2.385AspAsn: 2.385 ± 0.066	1.259AspPro: 1.259 ± 0.049	0.897AspGln: 0.897 ± 0.042	1.582AspArg: 1.582 ± 0.054	2.758AspSer: 2.758 ± 0.076	3.223AspThr: 3.223 ± 0.075	3.761AspVal: 3.761 ± 0.075	0.382AspTrp: 0.382 ± 0.028	2.082AspTyr: 2.082 ± 0.049	0.017AspXaa: 0.017 ± 0.005
Glu	5.181GluAla: 5.181 ± 0.102	0.595GluCys: 0.595 ± 0.032	3.693GluAsp: 3.693 ± 0.088	5.369GluGlu: 5.369 ± 0.126	3.286GluPhe: 3.286 ± 0.083	3.591GluGly: 3.591 ± 0.074	1.626GluHis: 1.626 ± 0.053	6.281GluIle: 6.281 ± 0.125	6.381GluLys: 6.381 ± 0.109	7.874GluLeu: 7.874 ± 0.144	2.031GluMet: 2.031 ± 0.069	4.249GluAsn: 4.249 ± 0.087	1.483GluPro: 1.483 ± 0.051	2.271GluGln: 2.271 ± 0.062	2.581GluArg: 2.581 ± 0.063	4.285GluSer: 4.285 ± 0.083	3.142GluThr: 3.142 ± 0.07	4.522GluVal: 4.522 ± 0.08	0.528GluTrp: 0.528 ± 0.029	2.967GluTyr: 2.967 ± 0.078	0.014GluXaa: 0.014 ± 0.005
Phe	3.704PheAla: 3.704 ± 0.078	0.511PheCys: 0.511 ± 0.029	3.223PheAsp: 3.223 ± 0.077	3.674PheGlu: 3.674 ± 0.082	2.675PhePhe: 2.675 ± 0.07	3.416PheGly: 3.416 ± 0.088	0.904PheHis: 0.904 ± 0.036	3.902PheIle: 3.902 ± 0.094	3.386PheLys: 3.386 ± 0.073	5.061PheLeu: 5.061 ± 0.097	1.468PheMet: 1.468 ± 0.054	2.144PheAsn: 2.144 ± 0.057	1.148PhePro: 1.148 ± 0.05	1.142PheGln: 1.142 ± 0.046	1.535PheArg: 1.535 ± 0.048	3.8PheSer: 3.8 ± 0.083	2.76PheThr: 2.76 ± 0.075	3.566PheVal: 3.566 ± 0.082	0.435PheTrp: 0.435 ± 0.027	2.152PheTyr: 2.152 ± 0.065	0.008PheXaa: 0.008 ± 0.004
Gly	4.232GlyAla: 4.232 ± 0.108	0.8GlyCys: 0.8 ± 0.038	2.973GlyAsp: 2.973 ± 0.072	3.764GlyGlu: 3.764 ± 0.083	3.308GlyPhe: 3.308 ± 0.082	3.83GlyGly: 3.83 ± 0.097	1.214GlyHis: 1.214 ± 0.053	4.755GlyIle: 4.755 ± 0.091	4.157GlyLys: 4.157 ± 0.089	5.065GlyLeu: 5.065 ± 0.113	1.726GlyMet: 1.726 ± 0.058	2.385GlyAsn: 2.385 ± 0.071	0.88GlyPro: 0.88 ± 0.04	1.377GlyGln: 1.377 ± 0.052	2.042GlyArg: 2.042 ± 0.061	3.665GlySer: 3.665 ± 0.086	3.032GlyThr: 3.032 ± 0.078	4.658GlyVal: 4.658 ± 0.09	0.517GlyTrp: 0.517 ± 0.031	2.728GlyTyr: 2.728 ± 0.084	0.022GlyXaa: 0.022 ± 0.006
His	1.369HisAla: 1.369 ± 0.044	0.204HisCys: 0.204 ± 0.019	1.056HisAsp: 1.056 ± 0.042	1.554HisGlu: 1.554 ± 0.052	1.17HisPhe: 1.17 ± 0.038	1.245HisGly: 1.245 ± 0.046	0.592HisHis: 0.592 ± 0.032	1.79HisIle: 1.79 ± 0.056	1.557HisLys: 1.557 ± 0.05	1.927HisLeu: 1.927 ± 0.055	0.512HisMet: 0.512 ± 0.032	1.074HisAsn: 1.074 ± 0.053	0.907HisPro: 0.907 ± 0.041	0.694HisGln: 0.694 ± 0.034	0.688HisArg: 0.688 ± 0.036	1.36HisSer: 1.36 ± 0.052	1.201HisThr: 1.201 ± 0.047	1.029HisVal: 1.029 ± 0.044	0.133HisTrp: 0.133 ± 0.014	0.893HisTyr: 0.893 ± 0.04	0.0HisXaa: 0.0 ± 0.0
Ile	6.489IleAla: 6.489 ± 0.129	0.714IleCys: 0.714 ± 0.039	5.192IleAsp: 5.192 ± 0.093	6.401IleGlu: 6.401 ± 0.116	4.086IlePhe: 4.086 ± 0.091	4.902IleGly: 4.902 ± 0.112	1.543IleHis: 1.543 ± 0.047	6.18IleIle: 6.18 ± 0.112	6.274IleLys: 6.274 ± 0.11	7.834IleLeu: 7.834 ± 0.117	1.729IleMet: 1.729 ± 0.054	4.287IleAsn: 4.287 ± 0.087	2.468IlePro: 2.468 ± 0.062	2.544IleGln: 2.544 ± 0.058	2.461IleArg: 2.461 ± 0.065	5.693IleSer: 5.693 ± 0.105	4.21IleThr: 4.21 ± 0.083	5.286IleVal: 5.286 ± 0.093	0.536IleTrp: 0.536 ± 0.03	3.046IleTyr: 3.046 ± 0.072	0.019IleXaa: 0.019 ± 0.006
Lys	5.018LysAla: 5.018 ± 0.103	0.501LysCys: 0.501 ± 0.032	4.248LysAsp: 4.248 ± 0.084	7.758LysGlu: 7.758 ± 0.139	2.777LysPhe: 2.777 ± 0.064	3.491LysGly: 3.491 ± 0.086	1.635LysHis: 1.635 ± 0.054	7.238LysIle: 7.238 ± 0.107	6.94LysLys: 6.94 ± 0.13	7.044LysLeu: 7.044 ± 0.098	2.353LysMet: 2.353 ± 0.067	5.504LysAsn: 5.504 ± 0.101	2.093LysPro: 2.093 ± 0.061	2.52LysGln: 2.52 ± 0.069	3.111LysArg: 3.111 ± 0.072	4.937LysSer: 4.937 ± 0.088	4.216LysThr: 4.216 ± 0.092	4.503LysVal: 4.503 ± 0.097	0.511LysTrp: 0.511 ± 0.03	2.993LysTyr: 2.993 ± 0.07	0.014LysXaa: 0.014 ± 0.004
Leu	7.036LeuAla: 7.036 ± 0.114	0.935LeuCys: 0.935 ± 0.04	5.446LeuAsp: 5.446 ± 0.095	7.299LeuGlu: 7.299 ± 0.136	5.396LeuPhe: 5.396 ± 0.118	5.72LeuGly: 5.72 ± 0.106	2.287LeuHis: 2.287 ± 0.059	6.809LeuIle: 6.809 ± 0.119	8.055LeuLys: 8.055 ± 0.128	10.552LeuLeu: 10.552 ± 0.178	2.641LeuMet: 2.641 ± 0.075	4.606LeuAsn: 4.606 ± 0.088	3.258LeuPro: 3.258 ± 0.08	3.884LeuGln: 3.884 ± 0.082	3.617LeuArg: 3.617 ± 0.08	7.99LeuSer: 7.99 ± 0.124	4.635LeuThr: 4.635 ± 0.081	5.391LeuVal: 5.391 ± 0.091	0.764LeuTrp: 0.764 ± 0.039	3.825LeuTyr: 3.825 ± 0.082	0.03LeuXaa: 0.03 ± 0.006
Met	2.005MetAla: 2.005 ± 0.063	0.226MetCys: 0.226 ± 0.019	1.352MetAsp: 1.352 ± 0.042	1.458MetGlu: 1.458 ± 0.047	1.209MetPhe: 1.209 ± 0.047	1.593MetGly: 1.593 ± 0.054	0.592MetHis: 0.592 ± 0.034	2.163MetIle: 2.163 ± 0.06	2.315MetLys: 2.315 ± 0.063	2.705MetLeu: 2.705 ± 0.073	0.8MetMet: 0.8 ± 0.036	1.372MetAsn: 1.372 ± 0.047	1.074MetPro: 1.074 ± 0.038	1.472MetGln: 1.472 ± 0.051	1.098MetArg: 1.098 ± 0.039	2.125MetSer: 2.125 ± 0.056	1.172MetThr: 1.172 ± 0.044	1.504MetVal: 1.504 ± 0.054	0.185MetTrp: 0.185 ± 0.018	0.767MetTyr: 0.767 ± 0.037	0.006MetXaa: 0.006 ± 0.003
Asn	4.578AsnAla: 4.578 ± 0.094	0.379AsnCys: 0.379 ± 0.025	2.551AsnAsp: 2.551 ± 0.07	3.582AsnGlu: 3.582 ± 0.08	2.544AsnPhe: 2.544 ± 0.068	2.896AsnGly: 2.896 ± 0.066	0.915AsnHis: 0.915 ± 0.036	5.004AsnIle: 5.004 ± 0.103	3.819AsnLys: 3.819 ± 0.086	4.749AsnLeu: 4.749 ± 0.093	1.302AsnMet: 1.302 ± 0.042	2.447AsnAsn: 2.447 ± 0.079	1.999AsnPro: 1.999 ± 0.06	1.496AsnGln: 1.496 ± 0.052	1.696AsnArg: 1.696 ± 0.049	3.212AsnSer: 3.212 ± 0.083	2.696AsnThr: 2.696 ± 0.073	2.804AsnVal: 2.804 ± 0.061	0.33AsnTrp: 0.33 ± 0.024	2.075AsnTyr: 2.075 ± 0.058	0.011AsnXaa: 0.011 ± 0.004
Pro	1.656ProAla: 1.656 ± 0.058	0.219ProCys: 0.219 ± 0.02	1.479ProAsp: 1.479 ± 0.048	1.906ProGlu: 1.906 ± 0.06	1.69ProPhe: 1.69 ± 0.048	1.112ProGly: 1.112 ± 0.048	0.747ProHis: 0.747 ± 0.036	2.293ProIle: 2.293 ± 0.066	2.324ProLys: 2.324 ± 0.068	3.104ProLeu: 3.104 ± 0.073	0.769ProMet: 0.769 ± 0.04	1.532ProAsn: 1.532 ± 0.048	0.728ProPro: 0.728 ± 0.033	1.266ProGln: 1.266 ± 0.045	0.905ProArg: 0.905 ± 0.037	1.912ProSer: 1.912 ± 0.059	1.651ProThr: 1.651 ± 0.051	1.63ProVal: 1.63 ± 0.057	0.247ProTrp: 0.247 ± 0.02	1.407ProTyr: 1.407 ± 0.049	0.009ProXaa: 0.009 ± 0.004
Gln	2.074GlnAla: 2.074 ± 0.064	0.221GlnCys: 0.221 ± 0.02	1.568GlnAsp: 1.568 ± 0.055	2.973GlnGlu: 2.973 ± 0.077	1.112GlnPhe: 1.112 ± 0.041	1.533GlnGly: 1.533 ± 0.045	0.597GlnHis: 0.597 ± 0.031	2.617GlnIle: 2.617 ± 0.069	3.429GlnLys: 3.429 ± 0.074	2.641GlnLeu: 2.641 ± 0.069	0.962GlnMet: 0.962 ± 0.041	2.636GlnAsn: 2.636 ± 0.079	0.785GlnPro: 0.785 ± 0.038	1.001GlnGln: 1.001 ± 0.044	1.413GlnArg: 1.413 ± 0.051	2.221GlnSer: 2.221 ± 0.06	2.232GlnThr: 2.232 ± 0.064	1.646GlnVal: 1.646 ± 0.048	0.26GlnTrp: 0.26 ± 0.023	1.07GlnTyr: 1.07 ± 0.042	0.016GlnXaa: 0.016 ± 0.005
Arg	2.418ArgAla: 2.418 ± 0.051	0.309ArgCys: 0.309 ± 0.024	2.082ArgAsp: 2.082 ± 0.055	2.786ArgGlu: 2.786 ± 0.075	1.991ArgPhe: 1.991 ± 0.056	1.886ArgGly: 1.886 ± 0.061	0.802ArgHis: 0.802 ± 0.036	2.551ArgIle: 2.551 ± 0.064	2.241ArgLys: 2.241 ± 0.065	3.394ArgLeu: 3.394 ± 0.074	0.946ArgMet: 0.946 ± 0.036	1.511ArgAsn: 1.511 ± 0.044	0.935ArgPro: 0.935 ± 0.041	0.985ArgGln: 0.985 ± 0.037	1.3ArgArg: 1.3 ± 0.05	1.95ArgSer: 1.95 ± 0.06	1.533ArgThr: 1.533 ± 0.052	2.624ArgVal: 2.624 ± 0.068	0.299ArgTrp: 0.299 ± 0.023	1.627ArgTyr: 1.627 ± 0.051	0.013ArgXaa: 0.013 ± 0.004
Ser	4.757SerAla: 4.757 ± 0.098	0.702SerCys: 0.702 ± 0.036	3.653SerAsp: 3.653 ± 0.085	3.977SerGlu: 3.977 ± 0.089	3.696SerPhe: 3.696 ± 0.08	4.279SerGly: 4.279 ± 0.092	1.469SerHis: 1.469 ± 0.05	5.57SerIle: 5.57 ± 0.093	5.09SerLys: 5.09 ± 0.09	7.186SerLeu: 7.186 ± 0.124	1.793SerMet: 1.793 ± 0.054	3.039SerAsn: 3.039 ± 0.091	1.713SerPro: 1.713 ± 0.053	2.356SerGln: 2.356 ± 0.071	2.221SerArg: 2.221 ± 0.061	4.87SerSer: 4.87 ± 0.096	2.987SerThr: 2.987 ± 0.064	4.263SerVal: 4.263 ± 0.078	0.54SerTrp: 0.54 ± 0.028	2.802SerTyr: 2.802 ± 0.075	0.014SerXaa: 0.014 ± 0.005
Thr	3.327ThrAla: 3.327 ± 0.078	0.393ThrCys: 0.393 ± 0.025	2.479ThrAsp: 2.479 ± 0.073	2.244ThrGlu: 2.244 ± 0.065	2.487ThrPhe: 2.487 ± 0.062	2.747ThrGly: 2.747 ± 0.068	1.222ThrHis: 1.222 ± 0.045	4.389ThrIle: 4.389 ± 0.087	4.137ThrLys: 4.137 ± 0.085	6.42ThrLeu: 6.42 ± 0.104	1.172ThrMet: 1.172 ± 0.04	2.766ThrAsn: 2.766 ± 0.08	2.293ThrPro: 2.293 ± 0.061	2.591ThrGln: 2.591 ± 0.065	1.457ThrArg: 1.457 ± 0.046	3.324ThrSer: 3.324 ± 0.078	3.042ThrThr: 3.042 ± 0.099	2.633ThrVal: 2.633 ± 0.07	0.33ThrTrp: 0.33 ± 0.026	1.917ThrTyr: 1.917 ± 0.055	0.02ThrXaa: 0.02 ± 0.006
Val	5.166ValAla: 5.166 ± 0.102	0.642ValCys: 0.642 ± 0.034	3.684ValAsp: 3.684 ± 0.079	4.133ValGlu: 4.133 ± 0.086	2.799ValPhe: 2.799 ± 0.075	3.72ValGly: 3.72 ± 0.084	1.198ValHis: 1.198 ± 0.043	4.711ValIle: 4.711 ± 0.079	4.346ValLys: 4.346 ± 0.087	6.166ValLeu: 6.166 ± 0.104	1.751ValMet: 1.751 ± 0.058	2.874ValAsn: 2.874 ± 0.079	1.767ValPro: 1.767 ± 0.055	1.854ValGln: 1.854 ± 0.051	2.06ValArg: 2.06 ± 0.057	4.314ValSer: 4.314 ± 0.072	3.039ValThr: 3.039 ± 0.081	4.48ValVal: 4.48 ± 0.097	0.507ValTrp: 0.507 ± 0.027	2.237ValTyr: 2.237 ± 0.051	0.014ValXaa: 0.014 ± 0.005
Trp	0.482TrpAla: 0.482 ± 0.029	0.075TrpCys: 0.075 ± 0.011	0.399TrpAsp: 0.399 ± 0.024	0.448TrpGlu: 0.448 ± 0.029	0.406TrpPhe: 0.406 ± 0.026	0.506TrpGly: 0.506 ± 0.031	0.215TrpHis: 0.215 ± 0.02	0.661TrpIle: 0.661 ± 0.032	0.424TrpLys: 0.424 ± 0.031	0.814TrpLeu: 0.814 ± 0.036	0.287TrpMet: 0.287 ± 0.024	0.392TrpAsn: 0.392 ± 0.025	0.158TrpPro: 0.158 ± 0.017	0.282TrpGln: 0.282 ± 0.024	0.316TrpArg: 0.316 ± 0.02	0.523TrpSer: 0.523 ± 0.028	0.258TrpThr: 0.258 ± 0.021	0.471TrpVal: 0.471 ± 0.029	0.081TrpTrp: 0.081 ± 0.011	0.309TrpTyr: 0.309 ± 0.026	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.837TyrAla: 2.837 ± 0.082	0.335TyrCys: 0.335 ± 0.021	2.472TyrAsp: 2.472 ± 0.066	3.205TyrGlu: 3.205 ± 0.074	2.298TyrPhe: 2.298 ± 0.059	2.373TyrGly: 2.373 ± 0.063	0.791TyrHis: 0.791 ± 0.033	3.042TyrIle: 3.042 ± 0.077	3.316TyrLys: 3.316 ± 0.076	3.886TyrLeu: 3.886 ± 0.074	0.93TyrMet: 0.93 ± 0.037	1.878TyrAsn: 1.878 ± 0.055	1.262TyrPro: 1.262 ± 0.042	1.206TyrGln: 1.206 ± 0.049	1.419TyrArg: 1.419 ± 0.056	2.583TyrSer: 2.583 ± 0.071	1.975TyrThr: 1.975 ± 0.056	1.901TyrVal: 1.901 ± 0.052	0.343TyrTrp: 0.343 ± 0.025	1.588TyrTyr: 1.588 ± 0.066	0.005TyrXaa: 0.005 ± 0.002
Xaa	0.006XaaAla: 0.006 ± 0.003	0.006XaaCys: 0.006 ± 0.003	0.009XaaAsp: 0.009 ± 0.004	0.022XaaGlu: 0.022 ± 0.006	0.013XaaPhe: 0.013 ± 0.004	0.019XaaGly: 0.019 ± 0.006	0.008XaaHis: 0.008 ± 0.003	0.009XaaIle: 0.009 ± 0.004	0.019XaaLys: 0.019 ± 0.005	0.025XaaLeu: 0.025 ± 0.006	0.017XaaMet: 0.017 ± 0.006	0.017XaaAsn: 0.017 ± 0.005	0.009XaaPro: 0.009 ± 0.004	0.013XaaGln: 0.013 ± 0.005	0.019XaaArg: 0.019 ± 0.005	0.019XaaSer: 0.019 ± 0.006	0.011XaaThr: 0.011 ± 0.004	0.011XaaVal: 0.011 ± 0.004	0.003XaaTrp: 0.003 ± 0.002	0.005XaaTyr: 0.005 ± 0.003	0.044XaaXaa: 0.044 ± 0.008

Statistics based on 2274 proteins (638461 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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