Amino acid dipepetide frequency for Apis mellifera associated microvirus 50

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.494AlaAla: 11.494 ± 3.88
0.676AlaCys: 0.676 ± 0.472
4.733AlaAsp: 4.733 ± 0.768
9.466AlaGlu: 9.466 ± 2.202
2.028AlaPhe: 2.028 ± 0.904
8.79AlaGly: 8.79 ± 2.762
1.352AlaHis: 1.352 ± 0.746
4.057AlaIle: 4.057 ± 0.831
3.381AlaLys: 3.381 ± 1.282
8.79AlaLeu: 8.79 ± 4.632
3.381AlaMet: 3.381 ± 1.067
4.733AlaAsn: 4.733 ± 1.816
7.437AlaPro: 7.437 ± 3.067
6.761AlaGln: 6.761 ± 3.407
8.114AlaArg: 8.114 ± 1.901
5.409AlaSer: 5.409 ± 2.134
6.085AlaThr: 6.085 ± 2.857
2.028AlaVal: 2.028 ± 0.544
0.0AlaTrp: 0.0 ± 0.0
0.676AlaTyr: 0.676 ± 0.472
0.0AlaXaa: 0.0 ± 0.0
Cys
0.676CysAla: 0.676 ± 0.472
0.0CysCys: 0.0 ± 0.0
0.676CysAsp: 0.676 ± 0.472
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.676CysGly: 0.676 ± 0.691
0.0CysHis: 0.0 ± 0.28
0.0CysIle: 0.0 ± 0.0
0.0CysLys: 0.0 ± 0.0
0.676CysLeu: 0.676 ± 0.693
2.028CysMet: 2.028 ± 0.649
0.676CysAsn: 0.676 ± 0.865
0.0CysPro: 0.0 ± 0.0
0.0CysGln: 0.0 ± 0.0
1.352CysArg: 1.352 ± 1.383
0.676CysSer: 0.676 ± 0.472
0.0CysThr: 0.0 ± 0.0
0.676CysVal: 0.676 ± 0.472
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
6.085AspAla: 6.085 ± 1.059
0.676AspCys: 0.676 ± 0.693
5.409AspAsp: 5.409 ± 2.027
3.381AspGlu: 3.381 ± 1.703
2.028AspPhe: 2.028 ± 1.673
0.676AspGly: 0.676 ± 0.472
0.676AspHis: 0.676 ± 0.472
0.676AspIle: 0.676 ± 0.472
1.352AspLys: 1.352 ± 0.885
2.705AspLeu: 2.705 ± 0.921
1.352AspMet: 1.352 ± 0.635
1.352AspAsn: 1.352 ± 0.652
2.028AspPro: 2.028 ± 1.035
0.676AspGln: 0.676 ± 0.472
4.057AspArg: 4.057 ± 1.831
4.733AspSer: 4.733 ± 4.078
0.0AspThr: 0.0 ± 0.0
6.085AspVal: 6.085 ± 0.909
1.352AspTrp: 1.352 ± 0.652
2.028AspTyr: 2.028 ± 1.416
0.0AspXaa: 0.0 ± 0.0
Glu
8.79GluAla: 8.79 ± 3.671
0.0GluCys: 0.0 ± 0.0
5.409GluAsp: 5.409 ± 1.451
3.381GluGlu: 3.381 ± 1.498
5.409GluPhe: 5.409 ± 2.153
2.705GluGly: 2.705 ± 1.96
1.352GluHis: 1.352 ± 0.944
1.352GluIle: 1.352 ± 0.944
2.028GluLys: 2.028 ± 1.258
6.085GluLeu: 6.085 ± 1.287
0.676GluMet: 0.676 ± 0.684
0.0GluAsn: 0.0 ± 0.0
1.352GluPro: 1.352 ± 1.73
2.028GluGln: 2.028 ± 1.232
3.381GluArg: 3.381 ± 1.498
2.705GluSer: 2.705 ± 1.339
2.705GluThr: 2.705 ± 0.844
6.761GluVal: 6.761 ± 4.227
0.676GluTrp: 0.676 ± 0.691
3.381GluTyr: 3.381 ± 0.976
0.0GluXaa: 0.0 ± 0.0
Phe
4.057PheAla: 4.057 ± 0.829
0.0PheCys: 0.0 ± 0.0
0.676PheAsp: 0.676 ± 0.865
4.057PheGlu: 4.057 ± 2.867
3.381PhePhe: 3.381 ± 1.703
6.085PheGly: 6.085 ± 2.187
0.676PheHis: 0.676 ± 0.214
2.705PheIle: 2.705 ± 1.112
0.0PheLys: 0.0 ± 0.0
1.352PheLeu: 1.352 ± 0.798
0.0PheMet: 0.0 ± 0.383
0.0PheAsn: 0.0 ± 0.0
1.352PhePro: 1.352 ± 0.944
0.676PheGln: 0.676 ± 0.865
1.352PheArg: 1.352 ± 0.944
2.705PheSer: 2.705 ± 0.921
0.0PheThr: 0.0 ± 0.0
2.028PheVal: 2.028 ± 1.429
0.0PheTrp: 0.0 ± 0.0
2.028PheTyr: 2.028 ± 1.258
0.0PheXaa: 0.0 ± 0.0
Gly
10.818GlyAla: 10.818 ± 4.73
0.676GlyCys: 0.676 ± 0.691
5.409GlyAsp: 5.409 ± 1.771
2.705GlyGlu: 2.705 ± 1.304
1.352GlyPhe: 1.352 ± 1.383
10.818GlyGly: 10.818 ± 1.417
2.705GlyHis: 2.705 ± 1.07
3.381GlyIle: 3.381 ± 0.959
4.057GlyLys: 4.057 ± 1.138
4.057GlyLeu: 4.057 ± 1.069
1.352GlyMet: 1.352 ± 0.798
2.028GlyAsn: 2.028 ± 0.885
4.733GlyPro: 4.733 ± 2.223
1.352GlyGln: 1.352 ± 0.635
4.057GlyArg: 4.057 ± 2.115
6.761GlySer: 6.761 ± 2.625
4.057GlyThr: 4.057 ± 1.307
8.79GlyVal: 8.79 ± 1.753
0.676GlyTrp: 0.676 ± 0.472
1.352GlyTyr: 1.352 ± 0.944
0.0GlyXaa: 0.0 ± 0.0
His
1.352HisAla: 1.352 ± 1.383
0.0HisCys: 0.0 ± 0.0
0.676HisAsp: 0.676 ± 0.693
0.676HisGlu: 0.676 ± 0.691
0.676HisPhe: 0.676 ± 0.691
1.352HisGly: 1.352 ± 0.944
0.676HisHis: 0.676 ± 0.472
1.352HisIle: 1.352 ± 0.944
0.676HisLys: 0.676 ± 0.472
1.352HisLeu: 1.352 ± 0.944
0.0HisMet: 0.0 ± 0.0
0.676HisAsn: 0.676 ± 0.684
2.705HisPro: 2.705 ± 1.889
0.0HisGln: 0.0 ± 0.0
2.028HisArg: 2.028 ± 0.783
2.705HisSer: 2.705 ± 0.921
0.676HisThr: 0.676 ± 0.691
2.705HisVal: 2.705 ± 1.331
2.028HisTrp: 2.028 ± 0.764
2.028HisTyr: 2.028 ± 0.764
0.0HisXaa: 0.0 ± 0.0
Ile
0.676IleAla: 0.676 ± 0.472
0.0IleCys: 0.0 ± 0.0
1.352IleAsp: 1.352 ± 1.386
1.352IleGlu: 1.352 ± 0.944
1.352IlePhe: 1.352 ± 0.746
2.705IleGly: 2.705 ± 0.634
0.0IleHis: 0.0 ± 0.347
1.352IleIle: 1.352 ± 0.652
0.0IleLys: 0.0 ± 0.0
2.028IleLeu: 2.028 ± 1.258
1.352IleMet: 1.352 ± 0.519
3.381IleAsn: 3.381 ± 0.976
4.057IlePro: 4.057 ± 1.069
2.028IleGln: 2.028 ± 1.258
6.761IleArg: 6.761 ± 1.875
1.352IleSer: 1.352 ± 0.944
3.381IleThr: 3.381 ± 1.698
0.676IleVal: 0.676 ± 0.472
0.676IleTrp: 0.676 ± 0.472
1.352IleTyr: 1.352 ± 0.944
0.0IleXaa: 0.0 ± 0.0
Lys
1.352LysAla: 1.352 ± 1.383
0.676LysCys: 0.676 ± 0.691
2.028LysAsp: 2.028 ± 0.904
4.057LysGlu: 4.057 ± 1.027
0.676LysPhe: 0.676 ± 0.472
1.352LysGly: 1.352 ± 0.944
2.028LysHis: 2.028 ± 0.904
4.057LysIle: 4.057 ± 0.831
2.705LysLys: 2.705 ± 1.511
1.352LysLeu: 1.352 ± 0.873
1.352LysMet: 1.352 ± 0.885
0.676LysAsn: 0.676 ± 0.684
2.028LysPro: 2.028 ± 0.544
1.352LysGln: 1.352 ± 0.652
4.733LysArg: 4.733 ± 2.024
2.028LysSer: 2.028 ± 1.026
0.0LysThr: 0.0 ± 0.0
3.381LysVal: 3.381 ± 1.008
0.676LysTrp: 0.676 ± 0.691
1.352LysTyr: 1.352 ± 0.908
0.0LysXaa: 0.0 ± 0.0
Leu
6.085LeuAla: 6.085 ± 1.475
0.0LeuCys: 0.0 ± 0.0
3.381LeuAsp: 3.381 ± 1.787
4.733LeuGlu: 4.733 ± 1.999
1.352LeuPhe: 1.352 ± 0.652
6.085LeuGly: 6.085 ± 1.508
2.705LeuHis: 2.705 ± 1.817
2.028LeuIle: 2.028 ± 0.885
4.733LeuLys: 4.733 ± 1.527
4.733LeuLeu: 4.733 ± 2.601
0.676LeuMet: 0.676 ± 0.693
2.705LeuAsn: 2.705 ± 0.634
7.437LeuPro: 7.437 ± 2.001
4.733LeuGln: 4.733 ± 1.842
8.114LeuArg: 8.114 ± 1.264
7.437LeuSer: 7.437 ± 1.262
2.705LeuThr: 2.705 ± 1.252
1.352LeuVal: 1.352 ± 1.383
1.352LeuTrp: 1.352 ± 0.944
1.352LeuTyr: 1.352 ± 0.908
0.0LeuXaa: 0.0 ± 0.0
Met
2.028MetAla: 2.028 ± 0.544
0.0MetCys: 0.0 ± 0.0
0.0MetAsp: 0.0 ± 0.0
3.381MetGlu: 3.381 ± 2.607
0.676MetPhe: 0.676 ± 0.691
3.381MetGly: 3.381 ± 1.88
0.676MetHis: 0.676 ± 0.472
0.0MetIle: 0.0 ± 0.0
0.676MetLys: 0.676 ± 0.865
1.352MetLeu: 1.352 ± 0.652
0.676MetMet: 0.676 ± 0.691
0.676MetAsn: 0.676 ± 0.472
2.705MetPro: 2.705 ± 1.331
0.676MetGln: 0.676 ± 0.684
3.381MetArg: 3.381 ± 1.464
2.028MetSer: 2.028 ± 1.316
1.352MetThr: 1.352 ± 0.798
1.352MetVal: 1.352 ± 0.652
0.0MetTrp: 0.0 ± 0.0
0.676MetTyr: 0.676 ± 0.472
0.0MetXaa: 0.0 ± 0.0
Asn
2.705AsnAla: 2.705 ± 1.889
0.0AsnCys: 0.0 ± 0.0
0.676AsnAsp: 0.676 ± 0.693
2.028AsnGlu: 2.028 ± 1.232
0.676AsnPhe: 0.676 ± 0.472
2.028AsnGly: 2.028 ± 0.904
0.0AsnHis: 0.0 ± 0.0
0.676AsnIle: 0.676 ± 0.472
0.0AsnLys: 0.0 ± 0.0
0.676AsnLeu: 0.676 ± 0.472
0.676AsnMet: 0.676 ± 0.691
1.352AsnAsn: 1.352 ± 0.635
1.352AsnPro: 1.352 ± 0.873
1.352AsnGln: 1.352 ± 0.652
1.352AsnArg: 1.352 ± 0.652
2.705AsnSer: 2.705 ± 0.921
2.705AsnThr: 2.705 ± 0.921
3.381AsnVal: 3.381 ± 1.836
0.0AsnTrp: 0.0 ± 0.0
0.676AsnTyr: 0.676 ± 0.472
0.0AsnXaa: 0.0 ± 0.0
Pro
7.437ProAla: 7.437 ± 5.507
0.676ProCys: 0.676 ± 0.691
3.381ProAsp: 3.381 ± 0.963
4.057ProGlu: 4.057 ± 2.53
0.676ProPhe: 0.676 ± 0.472
5.409ProGly: 5.409 ± 2.181
2.028ProHis: 2.028 ± 1.328
1.352ProIle: 1.352 ± 0.652
2.705ProLys: 2.705 ± 0.911
7.437ProLeu: 7.437 ± 1.187
0.0ProMet: 0.0 ± 0.0
0.676ProAsn: 0.676 ± 0.472
7.437ProPro: 7.437 ± 4.014
3.381ProGln: 3.381 ± 2.567
5.409ProArg: 5.409 ± 3.401
7.437ProSer: 7.437 ± 1.187
6.085ProThr: 6.085 ± 1.605
4.733ProVal: 4.733 ± 1.463
0.676ProTrp: 0.676 ± 0.472
2.705ProTyr: 2.705 ± 1.267
0.0ProXaa: 0.0 ± 0.0
Gln
3.381GlnAla: 3.381 ± 0.959
0.676GlnCys: 0.676 ± 0.472
2.028GlnAsp: 2.028 ± 1.026
2.705GlnGlu: 2.705 ± 0.634
0.676GlnPhe: 0.676 ± 0.865
4.057GlnGly: 4.057 ± 1.808
0.0GlnHis: 0.0 ± 0.0
0.0GlnIle: 0.0 ± 0.0
1.352GlnLys: 1.352 ± 0.944
1.352GlnLeu: 1.352 ± 1.367
1.352GlnMet: 1.352 ± 0.798
0.0GlnAsn: 0.0 ± 0.0
2.705GlnPro: 2.705 ± 1.721
0.676GlnGln: 0.676 ± 0.472
4.733GlnArg: 4.733 ± 2.189
2.028GlnSer: 2.028 ± 1.416
2.705GlnThr: 2.705 ± 1.269
0.676GlnVal: 0.676 ± 0.472
0.676GlnTrp: 0.676 ± 0.472
0.676GlnTyr: 0.676 ± 0.691
0.0GlnXaa: 0.0 ± 0.0
Arg
8.114ArgAla: 8.114 ± 2.071
2.028ArgCys: 2.028 ± 0.764
2.028ArgAsp: 2.028 ± 0.735
5.409ArgGlu: 5.409 ± 1.476
3.381ArgPhe: 3.381 ± 2.121
3.381ArgGly: 3.381 ± 1.746
3.381ArgHis: 3.381 ± 1.215
3.381ArgIle: 3.381 ± 1.366
2.705ArgLys: 2.705 ± 2.068
7.437ArgLeu: 7.437 ± 1.442
2.705ArgMet: 2.705 ± 1.094
0.676ArgAsn: 0.676 ± 0.693
6.761ArgPro: 6.761 ± 2.736
2.705ArgGln: 2.705 ± 0.722
13.523ArgArg: 13.523 ± 4.671
6.761ArgSer: 6.761 ± 1.189
4.733ArgThr: 4.733 ± 1.93
6.085ArgVal: 6.085 ± 3.031
2.705ArgTrp: 2.705 ± 1.267
6.085ArgTyr: 6.085 ± 2.388
0.0ArgXaa: 0.0 ± 0.0
Ser
7.437SerAla: 7.437 ± 2.546
0.0SerCys: 0.0 ± 0.0
3.381SerAsp: 3.381 ± 1.153
3.381SerGlu: 3.381 ± 2.303
2.028SerPhe: 2.028 ± 1.232
6.085SerGly: 6.085 ± 2.179
2.028SerHis: 2.028 ± 0.678
3.381SerIle: 3.381 ± 0.987
6.761SerLys: 6.761 ± 2.268
8.79SerLeu: 8.79 ± 3.582
2.028SerMet: 2.028 ± 1.564
2.028SerAsn: 2.028 ± 1.232
4.057SerPro: 4.057 ± 1.47
0.0SerGln: 0.0 ± 0.0
7.437SerArg: 7.437 ± 1.074
10.142SerSer: 10.142 ± 1.944
2.705SerThr: 2.705 ± 1.287
5.409SerVal: 5.409 ± 2.102
4.057SerTrp: 4.057 ± 1.754
2.705SerTyr: 2.705 ± 0.577
0.0SerXaa: 0.0 ± 0.0
Thr
4.057ThrAla: 4.057 ± 1.772
0.676ThrCys: 0.676 ± 0.472
2.028ThrAsp: 2.028 ± 1.232
0.676ThrGlu: 0.676 ± 0.472
2.028ThrPhe: 2.028 ± 1.035
6.085ThrGly: 6.085 ± 1.343
0.676ThrHis: 0.676 ± 0.684
1.352ThrIle: 1.352 ± 0.944
1.352ThrLys: 1.352 ± 0.944
3.381ThrLeu: 3.381 ± 1.881
2.028ThrMet: 2.028 ± 0.735
0.0ThrAsn: 0.0 ± 0.0
4.057ThrPro: 4.057 ± 1.227
0.676ThrGln: 0.676 ± 0.472
2.028ThrArg: 2.028 ± 1.464
6.761ThrSer: 6.761 ± 1.284
0.676ThrThr: 0.676 ± 0.684
3.381ThrVal: 3.381 ± 0.959
0.676ThrTrp: 0.676 ± 0.691
2.028ThrTyr: 2.028 ± 0.544
0.0ThrXaa: 0.0 ± 0.0
Val
6.761ValAla: 6.761 ± 2.596
1.352ValCys: 1.352 ± 0.873
3.381ValAsp: 3.381 ± 1.208
2.705ValGlu: 2.705 ± 1.328
2.028ValPhe: 2.028 ± 1.039
7.437ValGly: 7.437 ± 2.079
1.352ValHis: 1.352 ± 0.944
2.028ValIle: 2.028 ± 1.464
2.705ValLys: 2.705 ± 0.722
4.733ValLeu: 4.733 ± 1.816
3.381ValMet: 3.381 ± 1.366
2.028ValAsn: 2.028 ± 0.764
6.085ValPro: 6.085 ± 2.328
1.352ValGln: 1.352 ± 0.635
5.409ValArg: 5.409 ± 1.751
4.057ValSer: 4.057 ± 1.396
2.705ValThr: 2.705 ± 1.07
5.409ValVal: 5.409 ± 2.113
0.0ValTrp: 0.0 ± 0.0
2.028ValTyr: 2.028 ± 1.416
0.0ValXaa: 0.0 ± 0.0
Trp
1.352TrpAla: 1.352 ± 0.635
0.0TrpCys: 0.0 ± 0.0
0.676TrpAsp: 0.676 ± 0.472
1.352TrpGlu: 1.352 ± 0.944
0.676TrpPhe: 0.676 ± 0.691
0.676TrpGly: 0.676 ± 0.472
1.352TrpHis: 1.352 ± 0.652
2.028TrpIle: 2.028 ± 0.764
0.676TrpLys: 0.676 ± 0.684
1.352TrpLeu: 1.352 ± 0.798
0.0TrpMet: 0.0 ± 0.0
0.676TrpAsn: 0.676 ± 0.472
2.705TrpPro: 2.705 ± 0.577
0.676TrpGln: 0.676 ± 0.472
1.352TrpArg: 1.352 ± 0.798
1.352TrpSer: 1.352 ± 0.635
0.676TrpThr: 0.676 ± 0.691
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.676TrpTyr: 0.676 ± 0.472
0.0TrpXaa: 0.0 ± 0.0
Tyr
4.733TyrAla: 4.733 ± 1.376
0.0TyrCys: 0.0 ± 0.0
0.0TyrAsp: 0.0 ± 0.0
0.676TyrGlu: 0.676 ± 0.472
2.028TyrPhe: 2.028 ± 0.885
1.352TyrGly: 1.352 ± 0.798
0.676TyrHis: 0.676 ± 0.691
0.676TyrIle: 0.676 ± 0.472
0.0TyrLys: 0.0 ± 0.0
4.057TyrLeu: 4.057 ± 1.398
0.0TyrMet: 0.0 ± 0.0
0.676TyrAsn: 0.676 ± 0.472
2.705TyrPro: 2.705 ± 1.516
1.352TyrGln: 1.352 ± 0.944
6.085TyrArg: 6.085 ± 2.505
4.057TyrSer: 4.057 ± 1.395
0.676TyrThr: 0.676 ± 0.472
2.028TyrVal: 2.028 ± 1.258
2.028TyrTrp: 2.028 ± 0.885
0.676TyrTyr: 0.676 ± 0.684
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 5 proteins (1480 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski