Amino acid dipepetide frequency for Kangiella koreensis (strain DSM 16069 / KCTC 12182 / SW-125)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	6.4AlaAla: 6.4 ± 0.113	0.846AlaCys: 0.846 ± 0.037	4.492AlaAsp: 4.492 ± 0.072	5.766AlaGlu: 5.766 ± 0.099	3.319AlaPhe: 3.319 ± 0.07	5.846AlaGly: 5.846 ± 0.092	1.598AlaHis: 1.598 ± 0.045	5.967AlaIle: 5.967 ± 0.104	4.945AlaLys: 4.945 ± 0.092	8.477AlaLeu: 8.477 ± 0.132	2.323AlaMet: 2.323 ± 0.056	3.454AlaAsn: 3.454 ± 0.067	2.695AlaPro: 2.695 ± 0.063	3.403AlaGln: 3.403 ± 0.07	3.426AlaArg: 3.426 ± 0.068	4.937AlaSer: 4.937 ± 0.086	4.126AlaThr: 4.126 ± 0.07	5.455AlaVal: 5.455 ± 0.095	0.937AlaTrp: 0.937 ± 0.039	2.373AlaTyr: 2.373 ± 0.053	0.0AlaXaa: 0.0 ± 0.0
Cys	0.68CysAla: 0.68 ± 0.027	0.114CysCys: 0.114 ± 0.012	0.548CysAsp: 0.548 ± 0.026	0.565CysGlu: 0.565 ± 0.025	0.359CysPhe: 0.359 ± 0.021	0.727CysGly: 0.727 ± 0.031	0.304CysHis: 0.304 ± 0.022	0.488CysIle: 0.488 ± 0.026	0.441CysLys: 0.441 ± 0.022	0.897CysLeu: 0.897 ± 0.031	0.202CysMet: 0.202 ± 0.016	0.321CysAsn: 0.321 ± 0.019	0.438CysPro: 0.438 ± 0.025	0.406CysGln: 0.406 ± 0.023	0.424CysArg: 0.424 ± 0.023	0.609CysSer: 0.609 ± 0.028	0.406CysThr: 0.406 ± 0.022	0.567CysVal: 0.567 ± 0.026	0.116CysTrp: 0.116 ± 0.012	0.284CysTyr: 0.284 ± 0.017	0.0CysXaa: 0.0 ± 0.0
Asp	4.172AspAla: 4.172 ± 0.072	0.55AspCys: 0.55 ± 0.024	3.434AspAsp: 3.434 ± 0.075	4.143AspGlu: 4.143 ± 0.09	2.68AspPhe: 2.68 ± 0.056	4.096AspGly: 4.096 ± 0.088	1.05AspHis: 1.05 ± 0.033	4.069AspIle: 4.069 ± 0.09	3.611AspLys: 3.611 ± 0.073	5.505AspLeu: 5.505 ± 0.097	1.531AspMet: 1.531 ± 0.044	2.711AspAsn: 2.711 ± 0.064	2.208AspPro: 2.208 ± 0.05	2.183AspGln: 2.183 ± 0.053	2.328AspArg: 2.328 ± 0.057	3.775AspSer: 3.775 ± 0.079	2.779AspThr: 2.779 ± 0.068	3.646AspVal: 3.646 ± 0.076	0.937AspTrp: 0.937 ± 0.037	2.377AspTyr: 2.377 ± 0.056	0.0AspXaa: 0.0 ± 0.0
Glu	5.469GluAla: 5.469 ± 0.098	0.487GluCys: 0.487 ± 0.023	3.334GluAsp: 3.334 ± 0.067	4.731GluGlu: 4.731 ± 0.094	2.689GluPhe: 2.689 ± 0.06	3.814GluGly: 3.814 ± 0.069	1.8GluHis: 1.8 ± 0.045	3.907GluIle: 3.907 ± 0.07	4.213GluLys: 4.213 ± 0.086	7.677GluLeu: 7.677 ± 0.122	1.734GluMet: 1.734 ± 0.046	2.6GluAsn: 2.6 ± 0.046	2.396GluPro: 2.396 ± 0.054	4.604GluGln: 4.604 ± 0.095	3.497GluArg: 3.497 ± 0.063	4.023GluSer: 4.023 ± 0.077	3.327GluThr: 3.327 ± 0.06	4.783GluVal: 4.783 ± 0.083	0.854GluTrp: 0.854 ± 0.034	2.04GluTyr: 2.04 ± 0.055	0.0GluXaa: 0.0 ± 0.0
Phe	3.542PheAla: 3.542 ± 0.078	0.433PheCys: 0.433 ± 0.022	2.873PheAsp: 2.873 ± 0.062	2.944PheGlu: 2.944 ± 0.062	1.834PhePhe: 1.834 ± 0.055	3.107PheGly: 3.107 ± 0.066	0.791PheHis: 0.791 ± 0.032	2.933PheIle: 2.933 ± 0.068	2.272PheLys: 2.272 ± 0.059	3.656PheLeu: 3.656 ± 0.078	1.041PheMet: 1.041 ± 0.04	2.025PheAsn: 2.025 ± 0.061	1.475PhePro: 1.475 ± 0.041	1.267PheGln: 1.267 ± 0.036	1.504PheArg: 1.504 ± 0.049	3.123PheSer: 3.123 ± 0.062	2.21PheThr: 2.21 ± 0.051	2.732PheVal: 2.732 ± 0.056	0.576PheTrp: 0.576 ± 0.03	1.529PheTyr: 1.529 ± 0.049	0.0PheXaa: 0.0 ± 0.0
Gly	5.087GlyAla: 5.087 ± 0.087	0.75GlyCys: 0.75 ± 0.031	3.868GlyAsp: 3.868 ± 0.072	4.28GlyGlu: 4.28 ± 0.079	3.393GlyPhe: 3.393 ± 0.07	4.903GlyGly: 4.903 ± 0.101	1.6GlyHis: 1.6 ± 0.042	4.714GlyIle: 4.714 ± 0.081	4.13GlyLys: 4.13 ± 0.075	6.9GlyLeu: 6.9 ± 0.097	1.94GlyMet: 1.94 ± 0.052	2.687GlyAsn: 2.687 ± 0.065	1.82GlyPro: 1.82 ± 0.069	2.79GlyGln: 2.79 ± 0.061	2.981GlyArg: 2.981 ± 0.066	4.235GlySer: 4.235 ± 0.084	3.373GlyThr: 3.373 ± 0.08	5.047GlyVal: 5.047 ± 0.086	1.021GlyTrp: 1.021 ± 0.039	2.635GlyTyr: 2.635 ± 0.059	0.0GlyXaa: 0.0 ± 0.0
His	1.434HisAla: 1.434 ± 0.041	0.291HisCys: 0.291 ± 0.019	1.195HisAsp: 1.195 ± 0.036	1.286HisGlu: 1.286 ± 0.04	1.045HisPhe: 1.045 ± 0.034	1.539HisGly: 1.539 ± 0.038	0.67HisHis: 0.67 ± 0.031	1.472HisIle: 1.472 ± 0.041	1.242HisLys: 1.242 ± 0.043	2.258HisLeu: 2.258 ± 0.051	0.53HisMet: 0.53 ± 0.028	0.97HisAsn: 0.97 ± 0.032	1.217HisPro: 1.217 ± 0.041	1.186HisGln: 1.186 ± 0.036	1.07HisArg: 1.07 ± 0.039	1.477HisSer: 1.477 ± 0.041	0.995HisThr: 0.995 ± 0.035	1.181HisVal: 1.181 ± 0.042	0.397HisTrp: 0.397 ± 0.023	0.9HisTyr: 0.9 ± 0.033	0.0HisXaa: 0.0 ± 0.0
Ile	5.966IleAla: 5.966 ± 0.094	0.625IleCys: 0.625 ± 0.026	4.404IleAsp: 4.404 ± 0.081	5.194IleGlu: 5.194 ± 0.081	2.498IlePhe: 2.498 ± 0.062	4.885IleGly: 4.885 ± 0.089	1.387IleHis: 1.387 ± 0.045	4.236IleIle: 4.236 ± 0.077	3.963IleLys: 3.963 ± 0.067	5.723IleLeu: 5.723 ± 0.086	1.321IleMet: 1.321 ± 0.035	3.128IleAsn: 3.128 ± 0.066	2.8IlePro: 2.8 ± 0.07	2.384IleGln: 2.384 ± 0.057	2.857IleArg: 2.857 ± 0.062	4.47IleSer: 4.47 ± 0.069	3.609IleThr: 3.609 ± 0.075	4.175IleVal: 4.175 ± 0.068	0.697IleTrp: 0.697 ± 0.028	1.894IleTyr: 1.894 ± 0.05	0.0IleXaa: 0.0 ± 0.0
Lys	5.037LysAla: 5.037 ± 0.093	0.287LysCys: 0.287 ± 0.025	3.4LysAsp: 3.4 ± 0.062	4.037LysGlu: 4.037 ± 0.082	1.759LysPhe: 1.759 ± 0.046	3.619LysGly: 3.619 ± 0.064	1.355LysHis: 1.355 ± 0.042	3.305LysIle: 3.305 ± 0.069	3.609LysLys: 3.609 ± 0.095	5.73LysLeu: 5.73 ± 0.095	1.335LysMet: 1.335 ± 0.042	2.294LysAsn: 2.294 ± 0.057	2.726LysPro: 2.726 ± 0.067	3.212LysGln: 3.212 ± 0.069	2.861LysArg: 2.861 ± 0.052	3.408LysSer: 3.408 ± 0.069	3.165LysThr: 3.165 ± 0.062	4.215LysVal: 4.215 ± 0.07	0.601LysTrp: 0.601 ± 0.026	1.492LysTyr: 1.492 ± 0.041	0.0LysXaa: 0.0 ± 0.0
Leu	9.238LeuAla: 9.238 ± 0.122	0.821LeuCys: 0.821 ± 0.03	5.731LeuAsp: 5.731 ± 0.089	6.721LeuGlu: 6.721 ± 0.1	4.126LeuPhe: 4.126 ± 0.079	6.633LeuGly: 6.633 ± 0.098	2.045LeuHis: 2.045 ± 0.05	6.749LeuIle: 6.749 ± 0.1	5.886LeuLys: 5.886 ± 0.099	10.626LeuLeu: 10.626 ± 0.168	2.634LeuMet: 2.634 ± 0.056	4.345LeuAsn: 4.345 ± 0.074	4.436LeuPro: 4.436 ± 0.068	3.979LeuGln: 3.979 ± 0.078	4.354LeuArg: 4.354 ± 0.08	7.335LeuSer: 7.335 ± 0.102	5.412LeuThr: 5.412 ± 0.083	6.78LeuVal: 6.78 ± 0.095	1.21LeuTrp: 1.21 ± 0.042	2.893LeuTyr: 2.893 ± 0.064	0.0LeuXaa: 0.0 ± 0.0
Met	2.41MetAla: 2.41 ± 0.053	0.182MetCys: 0.182 ± 0.015	1.251MetAsp: 1.251 ± 0.04	1.32MetGlu: 1.32 ± 0.038	0.842MetPhe: 0.842 ± 0.032	1.654MetGly: 1.654 ± 0.051	0.497MetHis: 0.497 ± 0.026	1.531MetIle: 1.531 ± 0.043	1.505MetLys: 1.505 ± 0.04	2.444MetLeu: 2.444 ± 0.06	0.73MetMet: 0.73 ± 0.029	1.111MetAsn: 1.111 ± 0.036	1.215MetPro: 1.215 ± 0.039	1.217MetGln: 1.217 ± 0.043	1.126MetArg: 1.126 ± 0.031	1.933MetSer: 1.933 ± 0.046	1.524MetThr: 1.524 ± 0.044	1.77MetVal: 1.77 ± 0.05	0.219MetTrp: 0.219 ± 0.016	0.499MetTyr: 0.499 ± 0.023	0.0MetXaa: 0.0 ± 0.0
Asn	3.103AsnAla: 3.103 ± 0.064	0.368AsnCys: 0.368 ± 0.021	2.627AsnAsp: 2.627 ± 0.064	2.463AsnGlu: 2.463 ± 0.049	1.682AsnPhe: 1.682 ± 0.048	2.974AsnGly: 2.974 ± 0.077	1.102AsnHis: 1.102 ± 0.035	2.845AsnIle: 2.845 ± 0.057	2.466AsnLys: 2.466 ± 0.061	3.996AsnLeu: 3.996 ± 0.089	0.958AsnMet: 0.958 ± 0.032	2.07AsnAsn: 2.07 ± 0.062	2.243AsnPro: 2.243 ± 0.045	2.26AsnGln: 2.26 ± 0.052	1.989AsnArg: 1.989 ± 0.048	2.763AsnSer: 2.763 ± 0.064	2.189AsnThr: 2.189 ± 0.046	2.423AsnVal: 2.423 ± 0.061	0.637AsnTrp: 0.637 ± 0.03	1.483AsnTyr: 1.483 ± 0.046	0.0AsnXaa: 0.0 ± 0.0
Pro	3.046ProAla: 3.046 ± 0.059	0.289ProCys: 0.289 ± 0.02	2.565ProAsp: 2.565 ± 0.06	3.496ProGlu: 3.496 ± 0.068	1.76ProPhe: 1.76 ± 0.046	2.553ProGly: 2.553 ± 0.056	0.881ProHis: 0.881 ± 0.035	2.669ProIle: 2.669 ± 0.059	2.215ProLys: 2.215 ± 0.05	3.859ProLeu: 3.859 ± 0.076	1.014ProMet: 1.014 ± 0.036	1.672ProAsn: 1.672 ± 0.049	1.176ProPro: 1.176 ± 0.044	1.735ProGln: 1.735 ± 0.053	1.386ProArg: 1.386 ± 0.033	2.338ProSer: 2.338 ± 0.051	1.962ProThr: 1.962 ± 0.054	3.012ProVal: 3.012 ± 0.067	0.463ProTrp: 0.463 ± 0.019	1.32ProTyr: 1.32 ± 0.041	0.0ProXaa: 0.0 ± 0.0
Gln	4.109GlnAla: 4.109 ± 0.079	0.302GlnCys: 0.302 ± 0.021	2.204GlnAsp: 2.204 ± 0.051	2.952GlnGlu: 2.952 ± 0.064	1.788GlnPhe: 1.788 ± 0.049	2.744GlnGly: 2.744 ± 0.055	1.156GlnHis: 1.156 ± 0.035	2.641GlnIle: 2.641 ± 0.057	2.562GlnLys: 2.562 ± 0.058	5.19GlnLeu: 5.19 ± 0.097	1.082GlnMet: 1.082 ± 0.032	1.737GlnAsn: 1.737 ± 0.051	1.814GlnPro: 1.814 ± 0.048	2.983GlnGln: 2.983 ± 0.078	2.162GlnArg: 2.162 ± 0.051	3.015GlnSer: 3.015 ± 0.071	2.182GlnThr: 2.182 ± 0.047	3.041GlnVal: 3.041 ± 0.059	0.653GlnTrp: 0.653 ± 0.029	1.493GlnTyr: 1.493 ± 0.046	0.0GlnXaa: 0.0 ± 0.0
Arg	3.193ArgAla: 3.193 ± 0.062	0.377ArgCys: 0.377 ± 0.02	2.457ArgAsp: 2.457 ± 0.058	3.033ArgGlu: 3.033 ± 0.066	2.111ArgPhe: 2.111 ± 0.052	2.644ArgGly: 2.644 ± 0.061	1.142ArgHis: 1.142 ± 0.038	3.017ArgIle: 3.017 ± 0.057	2.577ArgLys: 2.577 ± 0.05	4.707ArgLeu: 4.707 ± 0.084	1.201ArgMet: 1.201 ± 0.04	1.906ArgAsn: 1.906 ± 0.043	1.588ArgPro: 1.588 ± 0.038	2.217ArgGln: 2.217 ± 0.059	2.21ArgArg: 2.21 ± 0.053	2.569ArgSer: 2.569 ± 0.059	1.956ArgThr: 1.956 ± 0.046	3.019ArgVal: 3.019 ± 0.055	0.626ArgTrp: 0.626 ± 0.029	1.865ArgTyr: 1.865 ± 0.043	0.0ArgXaa: 0.0 ± 0.0
Ser	4.802SerAla: 4.802 ± 0.082	0.583SerCys: 0.583 ± 0.031	3.821SerAsp: 3.821 ± 0.064	4.411SerGlu: 4.411 ± 0.08	2.949SerPhe: 2.949 ± 0.059	4.803SerGly: 4.803 ± 0.093	1.474SerHis: 1.474 ± 0.05	4.45SerIle: 4.45 ± 0.078	3.576SerLys: 3.576 ± 0.068	6.91SerLeu: 6.91 ± 0.104	1.564SerMet: 1.564 ± 0.041	3.026SerAsn: 3.026 ± 0.069	2.495SerPro: 2.495 ± 0.06	2.79SerGln: 2.79 ± 0.055	2.856SerArg: 2.856 ± 0.062	4.477SerSer: 4.477 ± 0.099	3.125SerThr: 3.125 ± 0.062	4.374SerVal: 4.374 ± 0.087	0.883SerTrp: 0.883 ± 0.034	2.138SerTyr: 2.138 ± 0.049	0.0SerXaa: 0.0 ± 0.0
Thr	4.077ThrAla: 4.077 ± 0.081	0.406ThrCys: 0.406 ± 0.025	2.99ThrAsp: 2.99 ± 0.059	3.31ThrGlu: 3.31 ± 0.068	2.052ThrPhe: 2.052 ± 0.051	4.051ThrGly: 4.051 ± 0.076	1.113ThrHis: 1.113 ± 0.038	3.645ThrIle: 3.645 ± 0.074	2.369ThrLys: 2.369 ± 0.058	5.438ThrLeu: 5.438 ± 0.085	1.029ThrMet: 1.029 ± 0.033	2.041ThrAsn: 2.041 ± 0.055	2.297ThrPro: 2.297 ± 0.051	2.119ThrGln: 2.119 ± 0.054	2.119ThrArg: 2.119 ± 0.049	3.217ThrSer: 3.217 ± 0.066	2.601ThrThr: 2.601 ± 0.067	3.847ThrVal: 3.847 ± 0.073	0.528ThrTrp: 0.528 ± 0.028	1.576ThrTyr: 1.576 ± 0.05	0.0ThrXaa: 0.0 ± 0.0
Val	5.964ValAla: 5.964 ± 0.086	0.676ValCys: 0.676 ± 0.034	4.173ValAsp: 4.173 ± 0.079	4.758ValGlu: 4.758 ± 0.08	2.707ValPhe: 2.707 ± 0.06	4.499ValGly: 4.499 ± 0.078	1.218ValHis: 1.218 ± 0.036	4.946ValIle: 4.946 ± 0.079	3.659ValLys: 3.659 ± 0.065	6.634ValLeu: 6.634 ± 0.114	1.814ValMet: 1.814 ± 0.048	2.877ValAsn: 2.877 ± 0.068	2.487ValPro: 2.487 ± 0.054	2.183ValGln: 2.183 ± 0.055	2.795ValArg: 2.795 ± 0.05	4.774ValSer: 4.774 ± 0.078	3.857ValThr: 3.857 ± 0.082	4.719ValVal: 4.719 ± 0.088	0.853ValTrp: 0.853 ± 0.032	1.949ValTyr: 1.949 ± 0.047	0.0ValXaa: 0.0 ± 0.0
Trp	0.812TrpAla: 0.812 ± 0.032	0.127TrpCys: 0.127 ± 0.013	0.607TrpAsp: 0.607 ± 0.031	0.605TrpGlu: 0.605 ± 0.027	0.682TrpPhe: 0.682 ± 0.03	0.753TrpGly: 0.753 ± 0.032	0.36TrpHis: 0.36 ± 0.02	0.841TrpIle: 0.841 ± 0.035	0.591TrpLys: 0.591 ± 0.03	1.872TrpLeu: 1.872 ± 0.053	0.35TrpMet: 0.35 ± 0.019	0.469TrpAsn: 0.469 ± 0.021	0.452TrpPro: 0.452 ± 0.024	0.906TrpGln: 0.906 ± 0.038	0.656TrpArg: 0.656 ± 0.031	0.773TrpSer: 0.773 ± 0.035	0.55TrpThr: 0.55 ± 0.028	0.927TrpVal: 0.927 ± 0.032	0.231TrpTrp: 0.231 ± 0.02	0.445TrpTyr: 0.445 ± 0.027	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.247TyrAla: 2.247 ± 0.06	0.384TyrCys: 0.384 ± 0.021	1.81TyrAsp: 1.81 ± 0.05	1.965TyrGlu: 1.965 ± 0.054	1.592TyrPhe: 1.592 ± 0.047	2.306TyrGly: 2.306 ± 0.052	0.815TyrHis: 0.815 ± 0.031	1.789TyrIle: 1.789 ± 0.043	1.614TyrLys: 1.614 ± 0.043	3.455TyrLeu: 3.455 ± 0.067	0.648TyrMet: 0.648 ± 0.024	1.195TyrAsn: 1.195 ± 0.044	1.43TyrPro: 1.43 ± 0.044	1.987TyrGln: 1.987 ± 0.056	1.818TyrArg: 1.818 ± 0.053	2.255TyrSer: 2.255 ± 0.061	1.475TyrThr: 1.475 ± 0.044	1.829TyrVal: 1.829 ± 0.054	0.568TyrTrp: 0.568 ± 0.026	1.246TyrTyr: 1.246 ± 0.047	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2630 proteins (852378 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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