Amino acid dipepetide frequency for Vibrio phage vB_VchM-138

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.307AlaAla: 7.307 ± 0.985
0.501AlaCys: 0.501 ± 0.224
5.086AlaAsp: 5.086 ± 0.54
4.8AlaGlu: 4.8 ± 0.481
2.292AlaPhe: 2.292 ± 0.502
5.086AlaGly: 5.086 ± 0.691
1.791AlaHis: 1.791 ± 0.37
5.23AlaIle: 5.23 ± 0.624
4.012AlaLys: 4.012 ± 0.551
7.235AlaLeu: 7.235 ± 0.616
1.791AlaMet: 1.791 ± 0.395
3.224AlaAsn: 3.224 ± 0.547
2.866AlaPro: 2.866 ± 0.533
3.94AlaGln: 3.94 ± 0.64
5.23AlaArg: 5.23 ± 0.546
4.513AlaSer: 4.513 ± 0.57
5.23AlaThr: 5.23 ± 0.553
5.301AlaVal: 5.301 ± 0.748
0.788AlaTrp: 0.788 ± 0.237
2.436AlaTyr: 2.436 ± 0.432
0.0AlaXaa: 0.0 ± 0.0
Cys
0.573CysAla: 0.573 ± 0.188
0.0CysCys: 0.0 ± 0.0
1.003CysAsp: 1.003 ± 0.266
0.86CysGlu: 0.86 ± 0.202
0.645CysPhe: 0.645 ± 0.208
1.003CysGly: 1.003 ± 0.284
0.287CysHis: 0.287 ± 0.141
0.716CysIle: 0.716 ± 0.288
0.716CysLys: 0.716 ± 0.226
0.931CysLeu: 0.931 ± 0.232
0.287CysMet: 0.287 ± 0.148
1.003CysAsn: 1.003 ± 0.355
0.573CysPro: 0.573 ± 0.222
0.287CysGln: 0.287 ± 0.135
0.716CysArg: 0.716 ± 0.301
1.361CysSer: 1.361 ± 0.306
0.788CysThr: 0.788 ± 0.227
1.003CysVal: 1.003 ± 0.231
0.215CysTrp: 0.215 ± 0.157
0.43CysTyr: 0.43 ± 0.198
0.0CysXaa: 0.0 ± 0.0
Asp
6.447AspAla: 6.447 ± 0.584
0.501AspCys: 0.501 ± 0.192
4.728AspAsp: 4.728 ± 0.727
5.301AspGlu: 5.301 ± 0.588
2.006AspPhe: 2.006 ± 0.433
5.445AspGly: 5.445 ± 0.588
1.218AspHis: 1.218 ± 0.26
5.301AspIle: 5.301 ± 0.725
3.08AspLys: 3.08 ± 0.454
5.086AspLeu: 5.086 ± 0.733
1.791AspMet: 1.791 ± 0.326
3.582AspAsn: 3.582 ± 0.52
3.654AspPro: 3.654 ± 0.495
1.075AspGln: 1.075 ± 0.274
2.364AspArg: 2.364 ± 0.42
3.654AspSer: 3.654 ± 0.719
4.656AspThr: 4.656 ± 0.833
5.015AspVal: 5.015 ± 0.571
1.289AspTrp: 1.289 ± 0.226
2.436AspTyr: 2.436 ± 0.392
0.0AspXaa: 0.0 ± 0.0
Glu
4.513GluAla: 4.513 ± 0.604
1.146GluCys: 1.146 ± 0.341
1.863GluAsp: 1.863 ± 0.363
2.436GluGlu: 2.436 ± 0.45
2.937GluPhe: 2.937 ± 0.467
2.722GluGly: 2.722 ± 0.459
1.003GluHis: 1.003 ± 0.283
3.224GluIle: 3.224 ± 0.393
2.364GluLys: 2.364 ± 0.442
5.731GluLeu: 5.731 ± 0.53
1.719GluMet: 1.719 ± 0.409
1.934GluAsn: 1.934 ± 0.328
1.863GluPro: 1.863 ± 0.571
2.866GluGln: 2.866 ± 0.505
3.51GluArg: 3.51 ± 0.495
4.298GluSer: 4.298 ± 0.466
3.08GluThr: 3.08 ± 0.411
3.868GluVal: 3.868 ± 0.516
1.218GluTrp: 1.218 ± 0.256
2.579GluTyr: 2.579 ± 0.378
0.0GluXaa: 0.0 ± 0.0
Phe
3.08PheAla: 3.08 ± 0.453
0.501PheCys: 0.501 ± 0.203
3.224PheAsp: 3.224 ± 0.378
2.078PheGlu: 2.078 ± 0.432
0.645PhePhe: 0.645 ± 0.194
3.08PheGly: 3.08 ± 0.401
0.43PheHis: 0.43 ± 0.172
2.364PheIle: 2.364 ± 0.379
2.579PheLys: 2.579 ± 0.459
1.433PheLeu: 1.433 ± 0.332
0.573PheMet: 0.573 ± 0.2
2.364PheAsn: 2.364 ± 0.455
1.361PhePro: 1.361 ± 0.28
0.645PheGln: 0.645 ± 0.234
1.791PheArg: 1.791 ± 0.359
2.937PheSer: 2.937 ± 0.514
2.507PheThr: 2.507 ± 0.433
2.579PheVal: 2.579 ± 0.369
0.43PheTrp: 0.43 ± 0.18
1.719PheTyr: 1.719 ± 0.336
0.0PheXaa: 0.0 ± 0.0
Gly
5.516GlyAla: 5.516 ± 0.717
0.716GlyCys: 0.716 ± 0.257
5.659GlyAsp: 5.659 ± 0.647
4.585GlyGlu: 4.585 ± 0.551
2.006GlyPhe: 2.006 ± 0.347
5.086GlyGly: 5.086 ± 0.64
1.218GlyHis: 1.218 ± 0.299
4.155GlyIle: 4.155 ± 0.537
3.582GlyLys: 3.582 ± 0.567
5.445GlyLeu: 5.445 ± 0.565
2.078GlyMet: 2.078 ± 0.42
3.439GlyAsn: 3.439 ± 0.538
1.576GlyPro: 1.576 ± 0.405
2.292GlyGln: 2.292 ± 0.434
4.37GlyArg: 4.37 ± 0.577
4.656GlySer: 4.656 ± 0.623
4.8GlyThr: 4.8 ± 0.674
6.161GlyVal: 6.161 ± 0.61
0.931GlyTrp: 0.931 ± 0.23
2.651GlyTyr: 2.651 ± 0.539
0.0GlyXaa: 0.0 ± 0.0
His
1.289HisAla: 1.289 ± 0.373
0.287HisCys: 0.287 ± 0.154
1.648HisAsp: 1.648 ± 0.379
1.003HisGlu: 1.003 ± 0.22
0.501HisPhe: 0.501 ± 0.224
1.003HisGly: 1.003 ± 0.288
0.788HisHis: 0.788 ± 0.218
1.361HisIle: 1.361 ± 0.348
1.003HisLys: 1.003 ± 0.271
1.075HisLeu: 1.075 ± 0.283
0.287HisMet: 0.287 ± 0.145
1.218HisAsn: 1.218 ± 0.22
0.86HisPro: 0.86 ± 0.193
0.501HisGln: 0.501 ± 0.177
1.075HisArg: 1.075 ± 0.303
0.86HisSer: 0.86 ± 0.233
0.931HisThr: 0.931 ± 0.253
1.361HisVal: 1.361 ± 0.286
0.43HisTrp: 0.43 ± 0.129
0.716HisTyr: 0.716 ± 0.25
0.0HisXaa: 0.0 ± 0.0
Ile
6.089IleAla: 6.089 ± 0.658
0.358IleCys: 0.358 ± 0.131
5.588IleAsp: 5.588 ± 0.48
4.442IleGlu: 4.442 ± 0.502
1.576IlePhe: 1.576 ± 0.321
5.015IleGly: 5.015 ± 0.607
1.003IleHis: 1.003 ± 0.223
4.728IleIle: 4.728 ± 0.537
3.868IleLys: 3.868 ± 0.557
3.51IleLeu: 3.51 ± 0.54
1.504IleMet: 1.504 ± 0.381
4.298IleAsn: 4.298 ± 0.664
2.364IlePro: 2.364 ± 0.374
2.078IleGln: 2.078 ± 0.438
3.51IleArg: 3.51 ± 0.568
3.224IleSer: 3.224 ± 0.419
4.728IleThr: 4.728 ± 0.682
4.871IleVal: 4.871 ± 0.521
0.573IleTrp: 0.573 ± 0.188
2.006IleTyr: 2.006 ± 0.386
0.0IleXaa: 0.0 ± 0.0
Lys
4.227LysAla: 4.227 ± 0.505
1.146LysCys: 1.146 ± 0.291
2.937LysAsp: 2.937 ± 0.56
2.149LysGlu: 2.149 ± 0.346
2.078LysPhe: 2.078 ± 0.448
3.439LysGly: 3.439 ± 0.436
1.003LysHis: 1.003 ± 0.263
2.364LysIle: 2.364 ± 0.354
2.149LysLys: 2.149 ± 0.429
4.298LysLeu: 4.298 ± 0.508
2.579LysMet: 2.579 ± 0.402
2.006LysAsn: 2.006 ± 0.395
2.149LysPro: 2.149 ± 0.424
1.934LysGln: 1.934 ± 0.354
3.868LysArg: 3.868 ± 0.56
4.442LysSer: 4.442 ± 0.58
2.221LysThr: 2.221 ± 0.382
3.439LysVal: 3.439 ± 0.583
0.86LysTrp: 0.86 ± 0.244
2.149LysTyr: 2.149 ± 0.427
0.0LysXaa: 0.0 ± 0.0
Leu
5.373LeuAla: 5.373 ± 0.649
1.146LeuCys: 1.146 ± 0.301
5.445LeuAsp: 5.445 ± 0.59
3.439LeuGlu: 3.439 ± 0.517
3.295LeuPhe: 3.295 ± 0.411
5.23LeuGly: 5.23 ± 0.595
1.075LeuHis: 1.075 ± 0.341
4.585LeuIle: 4.585 ± 0.46
3.725LeuLys: 3.725 ± 0.65
6.018LeuLeu: 6.018 ± 0.799
2.579LeuMet: 2.579 ± 0.397
4.8LeuAsn: 4.8 ± 0.571
3.152LeuPro: 3.152 ± 0.371
3.08LeuGln: 3.08 ± 0.463
5.23LeuArg: 5.23 ± 0.487
5.158LeuSer: 5.158 ± 0.603
5.588LeuThr: 5.588 ± 0.657
4.083LeuVal: 4.083 ± 0.505
0.86LeuTrp: 0.86 ± 0.237
2.292LeuTyr: 2.292 ± 0.419
0.0LeuXaa: 0.0 ± 0.0
Met
2.006MetAla: 2.006 ± 0.406
0.358MetCys: 0.358 ± 0.146
1.075MetAsp: 1.075 ± 0.287
1.003MetGlu: 1.003 ± 0.246
1.218MetPhe: 1.218 ± 0.319
1.361MetGly: 1.361 ± 0.258
0.215MetHis: 0.215 ± 0.143
2.149MetIle: 2.149 ± 0.458
1.576MetLys: 1.576 ± 0.317
1.648MetLeu: 1.648 ± 0.346
0.716MetMet: 0.716 ± 0.183
1.576MetAsn: 1.576 ± 0.388
0.931MetPro: 0.931 ± 0.216
1.003MetGln: 1.003 ± 0.243
1.934MetArg: 1.934 ± 0.26
2.292MetSer: 2.292 ± 0.38
2.292MetThr: 2.292 ± 0.329
1.863MetVal: 1.863 ± 0.256
0.287MetTrp: 0.287 ± 0.136
0.501MetTyr: 0.501 ± 0.159
0.0MetXaa: 0.0 ± 0.0
Asn
4.656AsnAla: 4.656 ± 0.618
0.43AsnCys: 0.43 ± 0.159
3.654AsnAsp: 3.654 ± 0.502
2.221AsnGlu: 2.221 ± 0.341
1.504AsnPhe: 1.504 ± 0.29
4.012AsnGly: 4.012 ± 0.486
1.289AsnHis: 1.289 ± 0.373
3.009AsnIle: 3.009 ± 0.401
3.725AsnLys: 3.725 ± 0.54
3.797AsnLeu: 3.797 ± 0.629
1.576AsnMet: 1.576 ± 0.287
3.582AsnAsn: 3.582 ± 0.591
3.009AsnPro: 3.009 ± 0.547
2.149AsnGln: 2.149 ± 0.393
2.507AsnArg: 2.507 ± 0.368
2.651AsnSer: 2.651 ± 0.349
3.582AsnThr: 3.582 ± 0.56
3.797AsnVal: 3.797 ± 0.504
0.501AsnTrp: 0.501 ± 0.152
2.006AsnTyr: 2.006 ± 0.276
0.0AsnXaa: 0.0 ± 0.0
Pro
3.08ProAla: 3.08 ± 0.39
0.86ProCys: 0.86 ± 0.212
2.722ProAsp: 2.722 ± 0.339
3.009ProGlu: 3.009 ± 0.463
1.433ProPhe: 1.433 ± 0.337
2.221ProGly: 2.221 ± 0.417
1.075ProHis: 1.075 ± 0.283
2.292ProIle: 2.292 ± 0.485
2.149ProLys: 2.149 ± 0.402
2.866ProLeu: 2.866 ± 0.469
0.501ProMet: 0.501 ± 0.231
2.221ProAsn: 2.221 ± 0.38
3.868ProPro: 3.868 ± 1.885
2.436ProGln: 2.436 ± 0.439
2.149ProArg: 2.149 ± 0.4
2.722ProSer: 2.722 ± 0.448
3.08ProThr: 3.08 ± 0.434
3.367ProVal: 3.367 ± 0.596
0.645ProTrp: 0.645 ± 0.257
1.504ProTyr: 1.504 ± 0.3
0.0ProXaa: 0.0 ± 0.0
Gln
2.436GlnAla: 2.436 ± 0.395
0.86GlnCys: 0.86 ± 0.281
2.006GlnAsp: 2.006 ± 0.399
1.648GlnGlu: 1.648 ± 0.315
2.006GlnPhe: 2.006 ± 0.347
1.791GlnGly: 1.791 ± 0.408
0.788GlnHis: 0.788 ± 0.3
2.149GlnIle: 2.149 ± 0.334
1.433GlnLys: 1.433 ± 0.258
4.155GlnLeu: 4.155 ± 0.537
0.931GlnMet: 0.931 ± 0.202
1.433GlnAsn: 1.433 ± 0.345
2.221GlnPro: 2.221 ± 0.43
2.078GlnGln: 2.078 ± 0.416
3.439GlnArg: 3.439 ± 0.614
2.221GlnSer: 2.221 ± 0.37
2.078GlnThr: 2.078 ± 0.392
1.719GlnVal: 1.719 ± 0.314
0.931GlnTrp: 0.931 ± 0.241
1.648GlnTyr: 1.648 ± 0.339
0.0GlnXaa: 0.0 ± 0.0
Arg
4.442ArgAla: 4.442 ± 0.461
0.931ArgCys: 0.931 ± 0.225
4.012ArgAsp: 4.012 ± 0.532
2.292ArgGlu: 2.292 ± 0.349
2.292ArgPhe: 2.292 ± 0.41
4.513ArgGly: 4.513 ± 0.59
0.931ArgHis: 0.931 ± 0.27
4.012ArgIle: 4.012 ± 0.54
4.442ArgLys: 4.442 ± 0.685
4.871ArgLeu: 4.871 ± 0.523
2.149ArgMet: 2.149 ± 0.376
3.152ArgAsn: 3.152 ± 0.438
1.863ArgPro: 1.863 ± 0.428
2.149ArgGln: 2.149 ± 0.423
3.08ArgArg: 3.08 ± 0.53
2.794ArgSer: 2.794 ± 0.355
2.436ArgThr: 2.436 ± 0.31
3.868ArgVal: 3.868 ± 0.596
1.075ArgTrp: 1.075 ± 0.323
2.149ArgTyr: 2.149 ± 0.343
0.0ArgXaa: 0.0 ± 0.0
Ser
5.086SerAla: 5.086 ± 0.62
0.501SerCys: 0.501 ± 0.193
3.797SerAsp: 3.797 ± 0.402
2.651SerGlu: 2.651 ± 0.417
2.651SerPhe: 2.651 ± 0.381
5.445SerGly: 5.445 ± 0.645
0.86SerHis: 0.86 ± 0.279
4.656SerIle: 4.656 ± 0.604
3.224SerLys: 3.224 ± 0.456
4.8SerLeu: 4.8 ± 0.548
1.719SerMet: 1.719 ± 0.333
3.51SerAsn: 3.51 ± 0.54
2.722SerPro: 2.722 ± 0.533
2.794SerGln: 2.794 ± 0.51
3.725SerArg: 3.725 ± 0.502
3.725SerSer: 3.725 ± 0.406
4.012SerThr: 4.012 ± 0.527
4.442SerVal: 4.442 ± 0.605
0.86SerTrp: 0.86 ± 0.228
1.863SerTyr: 1.863 ± 0.292
0.0SerXaa: 0.0 ± 0.0
Thr
3.582ThrAla: 3.582 ± 0.501
0.788ThrCys: 0.788 ± 0.245
4.227ThrAsp: 4.227 ± 0.497
3.654ThrGlu: 3.654 ± 0.612
2.221ThrPhe: 2.221 ± 0.406
5.588ThrGly: 5.588 ± 0.563
1.289ThrHis: 1.289 ± 0.362
4.871ThrIle: 4.871 ± 0.703
2.651ThrLys: 2.651 ± 0.469
5.445ThrLeu: 5.445 ± 0.613
1.433ThrMet: 1.433 ± 0.297
3.868ThrAsn: 3.868 ± 0.483
5.015ThrPro: 5.015 ± 0.759
2.794ThrGln: 2.794 ± 0.531
2.937ThrArg: 2.937 ± 0.519
3.51ThrSer: 3.51 ± 0.442
4.155ThrThr: 4.155 ± 0.583
4.513ThrVal: 4.513 ± 0.522
0.86ThrTrp: 0.86 ± 0.199
1.863ThrTyr: 1.863 ± 0.439
0.0ThrXaa: 0.0 ± 0.0
Val
5.731ValAla: 5.731 ± 0.612
1.003ValCys: 1.003 ± 0.256
5.301ValAsp: 5.301 ± 0.454
4.227ValGlu: 4.227 ± 0.645
2.579ValPhe: 2.579 ± 0.411
4.871ValGly: 4.871 ± 0.578
1.075ValHis: 1.075 ± 0.278
4.656ValIle: 4.656 ± 0.532
2.866ValLys: 2.866 ± 0.373
4.442ValLeu: 4.442 ± 0.486
1.003ValMet: 1.003 ± 0.279
3.654ValAsn: 3.654 ± 0.44
2.364ValPro: 2.364 ± 0.363
1.934ValGln: 1.934 ± 0.339
3.224ValArg: 3.224 ± 0.501
5.23ValSer: 5.23 ± 0.652
6.591ValThr: 6.591 ± 0.933
4.37ValVal: 4.37 ± 0.568
0.788ValTrp: 0.788 ± 0.204
2.937ValTyr: 2.937 ± 0.441
0.0ValXaa: 0.0 ± 0.0
Trp
0.788TrpAla: 0.788 ± 0.238
0.43TrpCys: 0.43 ± 0.167
1.289TrpAsp: 1.289 ± 0.249
0.501TrpGlu: 0.501 ± 0.215
0.788TrpPhe: 0.788 ± 0.223
1.003TrpGly: 1.003 ± 0.245
0.072TrpHis: 0.072 ± 0.077
0.716TrpIle: 0.716 ± 0.212
0.931TrpLys: 0.931 ± 0.271
1.576TrpLeu: 1.576 ± 0.289
0.358TrpMet: 0.358 ± 0.145
0.716TrpAsn: 0.716 ± 0.237
0.573TrpPro: 0.573 ± 0.218
0.358TrpGln: 0.358 ± 0.139
0.573TrpArg: 0.573 ± 0.192
1.075TrpSer: 1.075 ± 0.232
0.716TrpThr: 0.716 ± 0.23
0.931TrpVal: 0.931 ± 0.183
0.501TrpTrp: 0.501 ± 0.2
0.287TrpTyr: 0.287 ± 0.156
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.436TyrAla: 2.436 ± 0.417
0.931TyrCys: 0.931 ± 0.28
3.367TyrAsp: 3.367 ± 0.415
2.579TyrGlu: 2.579 ± 0.331
1.648TyrPhe: 1.648 ± 0.317
3.009TyrGly: 3.009 ± 0.496
0.788TyrHis: 0.788 ± 0.235
2.794TyrIle: 2.794 ± 0.446
1.361TyrLys: 1.361 ± 0.25
1.791TyrLeu: 1.791 ± 0.318
0.358TyrMet: 0.358 ± 0.181
2.078TyrAsn: 2.078 ± 0.323
1.218TyrPro: 1.218 ± 0.358
1.576TyrGln: 1.576 ± 0.334
2.221TyrArg: 2.221 ± 0.35
1.719TyrSer: 1.719 ± 0.343
1.863TyrThr: 1.863 ± 0.363
2.292TyrVal: 2.292 ± 0.386
0.143TyrTrp: 0.143 ± 0.094
1.289TyrTyr: 1.289 ± 0.327
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 67 proteins (13960 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski