Amino acid dipepetide frequency for Circovirus-like genome DCCV-8

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.34AlaAla: 11.34 ± 1.447
0.0AlaCys: 0.0 ± 0.0
4.124AlaAsp: 4.124 ± 1.307
2.062AlaGlu: 2.062 ± 1.07
2.062AlaPhe: 2.062 ± 1.478
4.124AlaGly: 4.124 ± 1.786
1.031AlaHis: 1.031 ± 0.756
3.093AlaIle: 3.093 ± 0.516
3.093AlaLys: 3.093 ± 2.267
6.186AlaLeu: 6.186 ± 3.372
2.062AlaMet: 2.062 ± 1.511
4.124AlaAsn: 4.124 ± 2.126
5.155AlaPro: 5.155 ± 3.337
3.093AlaGln: 3.093 ± 1.698
2.062AlaArg: 2.062 ± 0.819
3.093AlaSer: 3.093 ± 1.194
6.186AlaThr: 6.186 ± 1.209
2.062AlaVal: 2.062 ± 0.819
2.062AlaTrp: 2.062 ± 2.056
4.124AlaTyr: 4.124 ± 1.786
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
1.031CysCys: 1.031 ± 0.927
3.093CysAsp: 3.093 ± 1.739
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
1.031CysGly: 1.031 ± 1.028
0.0CysHis: 0.0 ± 0.0
3.093CysIle: 3.093 ± 0.516
1.031CysLys: 1.031 ± 0.756
0.0CysLeu: 0.0 ± 0.0
2.062CysMet: 2.062 ± 0.968
0.0CysAsn: 0.0 ± 0.0
2.062CysPro: 2.062 ± 1.855
0.0CysGln: 0.0 ± 0.0
0.0CysArg: 0.0 ± 0.0
0.0CysSer: 0.0 ± 0.0
1.031CysThr: 1.031 ± 1.028
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
3.093AspAla: 3.093 ± 2.267
1.031AspCys: 1.031 ± 0.756
1.031AspAsp: 1.031 ± 0.756
2.062AspGlu: 2.062 ± 2.056
2.062AspPhe: 2.062 ± 1.511
2.062AspGly: 2.062 ± 1.07
0.0AspHis: 0.0 ± 0.0
4.124AspIle: 4.124 ± 1.307
4.124AspLys: 4.124 ± 2.126
3.093AspLeu: 3.093 ± 1.698
0.0AspMet: 0.0 ± 0.0
1.031AspAsn: 1.031 ± 0.756
5.155AspPro: 5.155 ± 1.007
4.124AspGln: 4.124 ± 1.258
3.093AspArg: 3.093 ± 1.698
2.062AspSer: 2.062 ± 1.07
1.031AspThr: 1.031 ± 0.927
3.093AspVal: 3.093 ± 2.267
2.062AspTrp: 2.062 ± 1.478
4.124AspTyr: 4.124 ± 0.881
0.0AspXaa: 0.0 ± 0.0
Glu
3.093GluAla: 3.093 ± 3.084
1.031GluCys: 1.031 ± 0.927
0.0GluAsp: 0.0 ± 0.0
2.062GluGlu: 2.062 ± 2.056
6.186GluPhe: 6.186 ± 2.457
2.062GluGly: 2.062 ± 1.511
1.031GluHis: 1.031 ± 1.028
2.062GluIle: 2.062 ± 0.819
3.093GluLys: 3.093 ± 1.194
7.216GluLeu: 7.216 ± 2.191
0.0GluMet: 0.0 ± 0.0
2.062GluAsn: 2.062 ± 0.968
2.062GluPro: 2.062 ± 1.511
2.062GluGln: 2.062 ± 1.855
2.062GluArg: 2.062 ± 1.07
3.093GluSer: 3.093 ± 0.516
6.186GluThr: 6.186 ± 2.125
5.155GluVal: 5.155 ± 1.391
0.0GluTrp: 0.0 ± 0.0
0.0GluTyr: 0.0 ± 0.0
0.0GluXaa: 0.0 ± 0.0
Phe
1.031PheAla: 1.031 ± 1.157
0.0PheCys: 0.0 ± 0.0
1.031PheAsp: 1.031 ± 0.756
1.031PheGlu: 1.031 ± 1.028
1.031PhePhe: 1.031 ± 0.927
7.216PheGly: 7.216 ± 1.747
0.0PheHis: 0.0 ± 0.0
1.031PheIle: 1.031 ± 0.756
1.031PheLys: 1.031 ± 0.756
1.031PheLeu: 1.031 ± 0.756
1.031PheMet: 1.031 ± 0.927
1.031PheAsn: 1.031 ± 0.756
1.031PhePro: 1.031 ± 1.028
3.093PheGln: 3.093 ± 1.194
1.031PheArg: 1.031 ± 1.028
2.062PheSer: 2.062 ± 1.14
6.186PheThr: 6.186 ± 3.56
4.124PheVal: 4.124 ± 0.727
1.031PheTrp: 1.031 ± 1.028
1.031PheTyr: 1.031 ± 1.028
0.0PheXaa: 0.0 ± 0.0
Gly
5.155GlyAla: 5.155 ± 1.417
1.031GlyCys: 1.031 ± 0.927
4.124GlyAsp: 4.124 ± 1.155
6.186GlyGlu: 6.186 ± 2.117
1.031GlyPhe: 1.031 ± 0.756
5.155GlyGly: 5.155 ± 1.543
1.031GlyHis: 1.031 ± 0.927
5.155GlyIle: 5.155 ± 1.501
6.186GlyLys: 6.186 ± 3.786
5.155GlyLeu: 5.155 ± 2.523
3.093GlyMet: 3.093 ± 1.194
3.093GlyAsn: 3.093 ± 1.09
2.062GlyPro: 2.062 ± 0.819
3.093GlyGln: 3.093 ± 1.194
5.155GlyArg: 5.155 ± 1.619
6.186GlySer: 6.186 ± 3.783
5.155GlyThr: 5.155 ± 1.391
3.093GlyVal: 3.093 ± 1.739
1.031GlyTrp: 1.031 ± 0.927
3.093GlyTyr: 3.093 ± 2.268
0.0GlyXaa: 0.0 ± 0.0
His
2.062HisAla: 2.062 ± 0.968
0.0HisCys: 0.0 ± 0.0
0.0HisAsp: 0.0 ± 0.0
0.0HisGlu: 0.0 ± 0.0
0.0HisPhe: 0.0 ± 0.0
1.031HisGly: 1.031 ± 0.927
0.0HisHis: 0.0 ± 0.0
0.0HisIle: 0.0 ± 0.0
2.062HisLys: 2.062 ± 0.819
3.093HisLeu: 3.093 ± 0.516
0.0HisMet: 0.0 ± 0.0
0.0HisAsn: 0.0 ± 0.0
1.031HisPro: 1.031 ± 1.028
0.0HisGln: 0.0 ± 0.0
1.031HisArg: 1.031 ± 1.157
0.0HisSer: 0.0 ± 0.0
2.062HisThr: 2.062 ± 1.511
2.062HisVal: 2.062 ± 2.056
1.031HisTrp: 1.031 ± 1.028
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
5.155IleAla: 5.155 ± 1.417
1.031IleCys: 1.031 ± 1.028
5.155IleAsp: 5.155 ± 2.46
1.031IleGlu: 1.031 ± 1.028
0.0IlePhe: 0.0 ± 0.0
2.062IleGly: 2.062 ± 1.07
1.031IleHis: 1.031 ± 0.927
1.031IleIle: 1.031 ± 0.927
4.124IleLys: 4.124 ± 0.727
3.093IleLeu: 3.093 ± 1.469
2.062IleMet: 2.062 ± 1.855
2.062IleAsn: 2.062 ± 1.14
2.062IlePro: 2.062 ± 0.819
2.062IleGln: 2.062 ± 0.968
3.093IleArg: 3.093 ± 1.698
6.186IleSer: 6.186 ± 1.505
2.062IleThr: 2.062 ± 2.056
2.062IleVal: 2.062 ± 1.511
2.062IleTrp: 2.062 ± 1.07
3.093IleTyr: 3.093 ± 1.09
0.0IleXaa: 0.0 ± 0.0
Lys
7.216LysAla: 7.216 ± 2.045
0.0LysCys: 0.0 ± 0.0
3.093LysAsp: 3.093 ± 1.194
2.062LysGlu: 2.062 ± 2.056
2.062LysPhe: 2.062 ± 0.819
7.216LysGly: 7.216 ± 2.078
1.031LysHis: 1.031 ± 0.756
5.155LysIle: 5.155 ± 1.991
6.186LysLys: 6.186 ± 2.261
4.124LysLeu: 4.124 ± 1.937
3.093LysMet: 3.093 ± 1.26
2.062LysAsn: 2.062 ± 2.056
4.124LysPro: 4.124 ± 2.614
2.062LysGln: 2.062 ± 0.968
9.278LysArg: 9.278 ± 4.059
9.278LysSer: 9.278 ± 2.13
1.031LysThr: 1.031 ± 1.028
4.124LysVal: 4.124 ± 2.156
0.0LysTrp: 0.0 ± 0.0
2.062LysTyr: 2.062 ± 0.968
0.0LysXaa: 0.0 ± 0.0
Leu
2.062LeuAla: 2.062 ± 0.819
0.0LeuCys: 0.0 ± 0.0
5.155LeuAsp: 5.155 ± 2.46
4.124LeuGlu: 4.124 ± 1.937
1.031LeuPhe: 1.031 ± 0.756
5.155LeuGly: 5.155 ± 1.963
3.093LeuHis: 3.093 ± 1.883
2.062LeuIle: 2.062 ± 0.819
7.216LeuLys: 7.216 ± 2.077
6.186LeuLeu: 6.186 ± 2.261
1.031LeuMet: 1.031 ± 1.157
3.093LeuAsn: 3.093 ± 1.469
5.155LeuPro: 5.155 ± 2.755
5.155LeuGln: 5.155 ± 1.501
3.093LeuArg: 3.093 ± 1.719
6.186LeuSer: 6.186 ± 2.676
4.124LeuThr: 4.124 ± 2.546
4.124LeuVal: 4.124 ± 1.638
0.0LeuTrp: 0.0 ± 0.0
2.062LeuTyr: 2.062 ± 1.511
0.0LeuXaa: 0.0 ± 0.0
Met
1.031MetAla: 1.031 ± 0.927
1.031MetCys: 1.031 ± 0.756
1.031MetAsp: 1.031 ± 0.756
1.031MetGlu: 1.031 ± 0.927
0.0MetPhe: 0.0 ± 0.0
2.062MetGly: 2.062 ± 2.315
2.062MetHis: 2.062 ± 0.819
1.031MetIle: 1.031 ± 0.756
2.062MetLys: 2.062 ± 0.968
3.093MetLeu: 3.093 ± 2.183
0.0MetMet: 0.0 ± 0.0
2.062MetAsn: 2.062 ± 1.07
1.031MetPro: 1.031 ± 1.157
2.062MetGln: 2.062 ± 0.968
3.093MetArg: 3.093 ± 1.194
2.062MetSer: 2.062 ± 1.48
1.031MetThr: 1.031 ± 0.756
0.0MetVal: 0.0 ± 0.0
0.0MetTrp: 0.0 ± 0.0
0.0MetTyr: 0.0 ± 0.0
0.0MetXaa: 0.0 ± 0.0
Asn
4.124AsnAla: 4.124 ± 1.638
1.031AsnCys: 1.031 ± 0.927
0.0AsnAsp: 0.0 ± 0.0
1.031AsnGlu: 1.031 ± 0.756
5.155AsnPhe: 5.155 ± 2.005
4.124AsnGly: 4.124 ± 1.823
0.0AsnHis: 0.0 ± 0.0
0.0AsnIle: 0.0 ± 0.0
2.062AsnLys: 2.062 ± 1.511
4.124AsnLeu: 4.124 ± 1.307
2.062AsnMet: 2.062 ± 0.968
2.062AsnAsn: 2.062 ± 1.478
1.031AsnPro: 1.031 ± 1.157
3.093AsnGln: 3.093 ± 1.469
2.062AsnArg: 2.062 ± 1.478
2.062AsnSer: 2.062 ± 1.48
2.062AsnThr: 2.062 ± 1.511
2.062AsnVal: 2.062 ± 0.819
1.031AsnTrp: 1.031 ± 1.028
1.031AsnTyr: 1.031 ± 0.756
0.0AsnXaa: 0.0 ± 0.0
Pro
1.031ProAla: 1.031 ± 1.028
0.0ProCys: 0.0 ± 0.0
2.062ProAsp: 2.062 ± 0.968
5.155ProGlu: 5.155 ± 1.007
2.062ProPhe: 2.062 ± 0.819
5.155ProGly: 5.155 ± 1.98
0.0ProHis: 0.0 ± 0.0
1.031ProIle: 1.031 ± 0.927
2.062ProLys: 2.062 ± 0.968
4.124ProLeu: 4.124 ± 2.546
2.062ProMet: 2.062 ± 1.068
2.062ProAsn: 2.062 ± 0.819
2.062ProPro: 2.062 ± 1.855
1.031ProGln: 1.031 ± 1.157
5.155ProArg: 5.155 ± 1.501
10.309ProSer: 10.309 ± 2.424
3.093ProThr: 3.093 ± 1.739
5.155ProVal: 5.155 ± 1.007
0.0ProTrp: 0.0 ± 0.0
2.062ProTyr: 2.062 ± 1.14
0.0ProXaa: 0.0 ± 0.0
Gln
3.093GlnAla: 3.093 ± 1.883
0.0GlnCys: 0.0 ± 0.0
1.031GlnAsp: 1.031 ± 0.927
4.124GlnGlu: 4.124 ± 0.727
1.031GlnPhe: 1.031 ± 0.756
4.124GlnGly: 4.124 ± 1.823
0.0GlnHis: 0.0 ± 0.0
1.031GlnIle: 1.031 ± 1.028
1.031GlnLys: 1.031 ± 1.157
3.093GlnLeu: 3.093 ± 1.739
0.0GlnMet: 0.0 ± 0.876
0.0GlnAsn: 0.0 ± 0.0
2.062GlnPro: 2.062 ± 0.819
1.031GlnGln: 1.031 ± 0.756
3.093GlnArg: 3.093 ± 1.469
3.093GlnSer: 3.093 ± 2.782
0.0GlnThr: 0.0 ± 0.0
7.216GlnVal: 7.216 ± 1.684
0.0GlnTrp: 0.0 ± 0.0
1.031GlnTyr: 1.031 ± 0.756
0.0GlnXaa: 0.0 ± 0.0
Arg
4.124ArgAla: 4.124 ± 1.638
0.0ArgCys: 0.0 ± 0.0
4.124ArgAsp: 4.124 ± 1.307
1.031ArgGlu: 1.031 ± 0.927
1.031ArgPhe: 1.031 ± 0.756
4.124ArgGly: 4.124 ± 2.111
0.0ArgHis: 0.0 ± 0.0
2.062ArgIle: 2.062 ± 1.511
7.216ArgLys: 7.216 ± 3.311
3.093ArgLeu: 3.093 ± 0.516
1.031ArgMet: 1.031 ± 1.157
3.093ArgAsn: 3.093 ± 1.09
4.124ArgPro: 4.124 ± 1.823
1.031ArgGln: 1.031 ± 1.028
7.216ArgArg: 7.216 ± 2.115
6.186ArgSer: 6.186 ± 3.484
7.216ArgThr: 7.216 ± 0.735
5.155ArgVal: 5.155 ± 1.543
2.062ArgTrp: 2.062 ± 0.819
6.186ArgTyr: 6.186 ± 2.353
0.0ArgXaa: 0.0 ± 0.0
Ser
7.216SerAla: 7.216 ± 3.336
1.031SerCys: 1.031 ± 0.756
7.216SerAsp: 7.216 ± 2.191
4.124SerGlu: 4.124 ± 1.506
4.124SerPhe: 4.124 ± 0.727
2.062SerGly: 2.062 ± 1.478
1.031SerHis: 1.031 ± 1.028
2.062SerIle: 2.062 ± 1.855
7.216SerLys: 7.216 ± 3.519
2.062SerLeu: 2.062 ± 1.855
3.093SerMet: 3.093 ± 2.49
2.062SerAsn: 2.062 ± 1.07
3.093SerPro: 3.093 ± 2.782
2.062SerGln: 2.062 ± 1.855
5.155SerArg: 5.155 ± 2.46
6.186SerSer: 6.186 ± 1.734
5.155SerThr: 5.155 ± 1.963
8.247SerVal: 8.247 ± 3.45
2.062SerTrp: 2.062 ± 1.07
3.093SerTyr: 3.093 ± 1.55
0.0SerXaa: 0.0 ± 0.0
Thr
2.062ThrAla: 2.062 ± 1.07
2.062ThrCys: 2.062 ± 1.855
2.062ThrAsp: 2.062 ± 1.511
4.124ThrGlu: 4.124 ± 2.546
2.062ThrPhe: 2.062 ± 1.855
10.309ThrGly: 10.309 ± 2.086
0.0ThrHis: 0.0 ± 0.0
4.124ThrIle: 4.124 ± 1.638
8.247ThrLys: 8.247 ± 2.607
4.124ThrLeu: 4.124 ± 0.727
0.0ThrMet: 0.0 ± 0.0
7.216ThrAsn: 7.216 ± 3.309
4.124ThrPro: 4.124 ± 0.727
0.0ThrGln: 0.0 ± 0.0
3.093ThrArg: 3.093 ± 1.698
3.093ThrSer: 3.093 ± 1.506
0.0ThrThr: 0.0 ± 0.0
4.124ThrVal: 4.124 ± 2.156
0.0ThrTrp: 0.0 ± 0.0
0.0ThrTyr: 0.0 ± 0.0
0.0ThrXaa: 0.0 ± 0.0
Val
3.093ValAla: 3.093 ± 1.469
1.031ValCys: 1.031 ± 0.756
2.062ValAsp: 2.062 ± 1.511
7.216ValGlu: 7.216 ± 1.747
4.124ValPhe: 4.124 ± 1.638
3.093ValGly: 3.093 ± 1.09
3.093ValHis: 3.093 ± 1.09
6.186ValIle: 6.186 ± 2.117
3.093ValLys: 3.093 ± 1.698
5.155ValLeu: 5.155 ± 2.523
2.062ValMet: 2.062 ± 1.406
3.093ValAsn: 3.093 ± 1.194
7.216ValPro: 7.216 ± 1.01
1.031ValGln: 1.031 ± 0.756
5.155ValArg: 5.155 ± 0.655
3.093ValSer: 3.093 ± 1.719
5.155ValThr: 5.155 ± 3.337
8.247ValVal: 8.247 ± 2.498
0.0ValTrp: 0.0 ± 0.0
0.0ValTyr: 0.0 ± 0.0
0.0ValXaa: 0.0 ± 0.0
Trp
0.0TrpAla: 0.0 ± 0.0
3.093TrpCys: 3.093 ± 1.883
1.031TrpAsp: 1.031 ± 1.028
1.031TrpGlu: 1.031 ± 1.028
0.0TrpPhe: 0.0 ± 0.0
0.0TrpGly: 0.0 ± 0.0
0.0TrpHis: 0.0 ± 0.0
3.093TrpIle: 3.093 ± 1.883
0.0TrpLys: 0.0 ± 0.0
1.031TrpLeu: 1.031 ± 1.028
0.0TrpMet: 0.0 ± 0.0
0.0TrpAsn: 0.0 ± 0.0
0.0TrpPro: 0.0 ± 0.0
1.031TrpGln: 1.031 ± 1.028
2.062TrpArg: 2.062 ± 0.968
1.031TrpSer: 1.031 ± 0.927
1.031TrpThr: 1.031 ± 1.028
1.031TrpVal: 1.031 ± 1.157
0.0TrpTrp: 0.0 ± 0.0
1.031TrpTyr: 1.031 ± 1.028
0.0TrpXaa: 0.0 ± 0.0
Tyr
5.155TyrAla: 5.155 ± 2.834
0.0TyrCys: 0.0 ± 0.0
1.031TyrAsp: 1.031 ± 0.756
1.031TyrGlu: 1.031 ± 1.028
1.031TyrPhe: 1.031 ± 0.756
3.093TyrGly: 3.093 ± 1.09
1.031TyrHis: 1.031 ± 0.756
3.093TyrIle: 3.093 ± 2.268
4.124TyrLys: 4.124 ± 1.506
1.031TyrLeu: 1.031 ± 1.028
0.0TyrMet: 0.0 ± 0.0
0.0TyrAsn: 0.0 ± 0.0
1.031TyrPro: 1.031 ± 1.028
0.0TyrGln: 0.0 ± 0.0
4.124TyrArg: 4.124 ± 2.957
3.093TyrSer: 3.093 ± 1.09
1.031TyrThr: 1.031 ± 0.756
2.062TyrVal: 2.062 ± 0.819
2.062TyrTrp: 2.062 ± 1.07
2.062TyrTyr: 2.062 ± 0.819
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (971 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski