Amino acid dipepetide frequency for Arenibacter nanhaiticus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.815AlaAla: 4.815 ± 0.081
0.525AlaCys: 0.525 ± 0.02
3.381AlaAsp: 3.381 ± 0.061
4.014AlaGlu: 4.014 ± 0.067
3.263AlaPhe: 3.263 ± 0.057
4.202AlaGly: 4.202 ± 0.069
1.275AlaHis: 1.275 ± 0.033
5.424AlaIle: 5.424 ± 0.075
4.835AlaLys: 4.835 ± 0.073
6.707AlaLeu: 6.707 ± 0.087
1.779AlaMet: 1.779 ± 0.038
3.462AlaAsn: 3.462 ± 0.058
2.261AlaPro: 2.261 ± 0.051
2.554AlaGln: 2.554 ± 0.047
2.036AlaArg: 2.036 ± 0.041
4.273AlaSer: 4.273 ± 0.063
3.947AlaThr: 3.947 ± 0.075
4.327AlaVal: 4.327 ± 0.058
0.667AlaTrp: 0.667 ± 0.023
2.679AlaTyr: 2.679 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
0.416CysAla: 0.416 ± 0.018
0.099CysCys: 0.099 ± 0.01
0.39CysAsp: 0.39 ± 0.02
0.406CysGlu: 0.406 ± 0.017
0.421CysPhe: 0.421 ± 0.02
0.606CysGly: 0.606 ± 0.026
0.184CysHis: 0.184 ± 0.011
0.549CysIle: 0.549 ± 0.022
0.483CysLys: 0.483 ± 0.022
0.657CysLeu: 0.657 ± 0.027
0.159CysMet: 0.159 ± 0.01
0.41CysAsn: 0.41 ± 0.02
0.315CysPro: 0.315 ± 0.019
0.222CysGln: 0.222 ± 0.012
0.207CysArg: 0.207 ± 0.012
0.544CysSer: 0.544 ± 0.027
0.459CysThr: 0.459 ± 0.023
0.376CysVal: 0.376 ± 0.017
0.071CysTrp: 0.071 ± 0.007
0.302CysTyr: 0.302 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
3.685AspAla: 3.685 ± 0.07
0.397AspCys: 0.397 ± 0.018
2.665AspAsp: 2.665 ± 0.049
3.271AspGlu: 3.271 ± 0.055
3.532AspPhe: 3.532 ± 0.062
3.85AspGly: 3.85 ± 0.075
1.092AspHis: 1.092 ± 0.03
4.513AspIle: 4.513 ± 0.07
4.04AspLys: 4.04 ± 0.055
5.222AspLeu: 5.222 ± 0.069
1.197AspMet: 1.197 ± 0.032
2.978AspAsn: 2.978 ± 0.049
2.013AspPro: 2.013 ± 0.043
1.779AspGln: 1.779 ± 0.04
2.126AspArg: 2.126 ± 0.047
3.059AspSer: 3.059 ± 0.058
2.787AspThr: 2.787 ± 0.05
3.296AspVal: 3.296 ± 0.051
0.818AspTrp: 0.818 ± 0.025
2.683AspTyr: 2.683 ± 0.053
0.0AspXaa: 0.0 ± 0.0
Glu
4.652GluAla: 4.652 ± 0.073
0.337GluCys: 0.337 ± 0.019
3.586GluAsp: 3.586 ± 0.048
5.034GluGlu: 5.034 ± 0.084
2.836GluPhe: 2.836 ± 0.05
4.067GluGly: 4.067 ± 0.056
1.186GluHis: 1.186 ± 0.032
5.222GluIle: 5.222 ± 0.063
5.912GluLys: 5.912 ± 0.081
6.288GluLeu: 6.288 ± 0.084
1.558GluMet: 1.558 ± 0.036
4.52GluAsn: 4.52 ± 0.073
1.556GluPro: 1.556 ± 0.036
2.248GluGln: 2.248 ± 0.043
2.575GluArg: 2.575 ± 0.047
3.201GluSer: 3.201 ± 0.051
3.431GluThr: 3.431 ± 0.062
4.556GluVal: 4.556 ± 0.068
0.677GluTrp: 0.677 ± 0.027
2.372GluTyr: 2.372 ± 0.043
0.0GluXaa: 0.0 ± 0.0
Phe
2.751PheAla: 2.751 ± 0.05
0.399PheCys: 0.399 ± 0.017
3.028PheAsp: 3.028 ± 0.047
3.176PheGlu: 3.176 ± 0.051
2.699PhePhe: 2.699 ± 0.059
3.638PheGly: 3.638 ± 0.062
0.881PheHis: 0.881 ± 0.028
3.717PheIle: 3.717 ± 0.06
3.797PheLys: 3.797 ± 0.061
4.846PheLeu: 4.846 ± 0.07
1.202PheMet: 1.202 ± 0.034
3.114PheAsn: 3.114 ± 0.051
1.811PhePro: 1.811 ± 0.041
1.565PheGln: 1.565 ± 0.038
1.752PheArg: 1.752 ± 0.038
3.98PheSer: 3.98 ± 0.063
2.88PheThr: 2.88 ± 0.05
2.882PheVal: 2.882 ± 0.049
0.575PheTrp: 0.575 ± 0.024
2.071PheTyr: 2.071 ± 0.044
0.0PheXaa: 0.0 ± 0.0
Gly
4.68GlyAla: 4.68 ± 0.071
0.621GlyCys: 0.621 ± 0.031
3.598GlyAsp: 3.598 ± 0.062
3.928GlyGlu: 3.928 ± 0.063
3.68GlyPhe: 3.68 ± 0.062
4.647GlyGly: 4.647 ± 0.084
1.295GlyHis: 1.295 ± 0.034
5.511GlyIle: 5.511 ± 0.083
5.129GlyLys: 5.129 ± 0.062
6.09GlyLeu: 6.09 ± 0.076
1.7GlyMet: 1.7 ± 0.047
3.693GlyAsn: 3.693 ± 0.069
1.519GlyPro: 1.519 ± 0.034
2.039GlyGln: 2.039 ± 0.042
2.306GlyArg: 2.306 ± 0.048
4.266GlySer: 4.266 ± 0.063
4.088GlyThr: 4.088 ± 0.059
4.637GlyVal: 4.637 ± 0.066
0.876GlyTrp: 0.876 ± 0.029
3.075GlyTyr: 3.075 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
1.042HisAla: 1.042 ± 0.031
0.194HisCys: 0.194 ± 0.013
0.827HisAsp: 0.827 ± 0.028
1.012HisGlu: 1.012 ± 0.03
1.106HisPhe: 1.106 ± 0.031
1.239HisGly: 1.239 ± 0.034
0.56HisHis: 0.56 ± 0.022
1.473HisIle: 1.473 ± 0.038
1.326HisLys: 1.326 ± 0.039
1.94HisLeu: 1.94 ± 0.044
0.404HisMet: 0.404 ± 0.016
0.958HisAsn: 0.958 ± 0.026
1.028HisPro: 1.028 ± 0.034
0.864HisGln: 0.864 ± 0.026
0.798HisArg: 0.798 ± 0.031
1.16HisSer: 1.16 ± 0.034
1.036HisThr: 1.036 ± 0.028
0.885HisVal: 0.885 ± 0.03
0.284HisTrp: 0.284 ± 0.015
0.918HisTyr: 0.918 ± 0.029
0.0HisXaa: 0.0 ± 0.0
Ile
5.659IleAla: 5.659 ± 0.079
0.586IleCys: 0.586 ± 0.026
4.549IleAsp: 4.549 ± 0.068
4.869IleGlu: 4.869 ± 0.062
3.367IlePhe: 3.367 ± 0.057
5.238IleGly: 5.238 ± 0.083
1.346IleHis: 1.346 ± 0.035
5.327IleIle: 5.327 ± 0.09
5.606IleLys: 5.606 ± 0.073
6.696IleLeu: 6.696 ± 0.089
1.41IleMet: 1.41 ± 0.039
4.288IleAsn: 4.288 ± 0.065
3.278IlePro: 3.278 ± 0.049
2.384IleGln: 2.384 ± 0.047
2.819IleArg: 2.819 ± 0.049
5.497IleSer: 5.497 ± 0.067
4.611IleThr: 4.611 ± 0.059
4.551IleVal: 4.551 ± 0.073
0.715IleTrp: 0.715 ± 0.024
2.653IleTyr: 2.653 ± 0.048
0.0IleXaa: 0.0 ± 0.0
Lys
5.079LysAla: 5.079 ± 0.079
0.338LysCys: 0.338 ± 0.017
4.605LysAsp: 4.605 ± 0.062
6.705LysGlu: 6.705 ± 0.096
2.76LysPhe: 2.76 ± 0.048
4.966LysGly: 4.966 ± 0.062
1.353LysHis: 1.353 ± 0.037
5.809LysIle: 5.809 ± 0.082
6.576LysLys: 6.576 ± 0.081
6.269LysLeu: 6.269 ± 0.072
1.845LysMet: 1.845 ± 0.042
4.992LysAsn: 4.992 ± 0.065
2.358LysPro: 2.358 ± 0.054
2.449LysGln: 2.449 ± 0.053
2.822LysArg: 2.822 ± 0.052
4.258LysSer: 4.258 ± 0.062
4.538LysThr: 4.538 ± 0.065
4.733LysVal: 4.733 ± 0.075
0.773LysTrp: 0.773 ± 0.024
2.831LysTyr: 2.831 ± 0.049
0.0LysXaa: 0.0 ± 0.0
Leu
6.196LeuAla: 6.196 ± 0.076
0.749LeuCys: 0.749 ± 0.028
5.082LeuAsp: 5.082 ± 0.065
6.543LeuGlu: 6.543 ± 0.08
4.756LeuPhe: 4.756 ± 0.075
6.414LeuGly: 6.414 ± 0.082
1.741LeuHis: 1.741 ± 0.041
6.335LeuIle: 6.335 ± 0.085
7.763LeuLys: 7.763 ± 0.088
9.341LeuLeu: 9.341 ± 0.096
2.245LeuMet: 2.245 ± 0.043
5.294LeuAsn: 5.294 ± 0.062
3.786LeuPro: 3.786 ± 0.055
3.511LeuGln: 3.511 ± 0.06
3.454LeuArg: 3.454 ± 0.052
6.801LeuSer: 6.801 ± 0.078
5.014LeuThr: 5.014 ± 0.065
5.631LeuVal: 5.631 ± 0.075
0.964LeuTrp: 0.964 ± 0.034
3.257LeuTyr: 3.257 ± 0.058
0.0LeuXaa: 0.0 ± 0.0
Met
1.941MetAla: 1.941 ± 0.043
0.132MetCys: 0.132 ± 0.01
1.362MetAsp: 1.362 ± 0.03
1.691MetGlu: 1.691 ± 0.038
0.85MetPhe: 0.85 ± 0.026
1.687MetGly: 1.687 ± 0.042
0.411MetHis: 0.411 ± 0.018
1.428MetIle: 1.428 ± 0.038
1.914MetLys: 1.914 ± 0.041
1.955MetLeu: 1.955 ± 0.04
0.542MetMet: 0.542 ± 0.021
1.186MetAsn: 1.186 ± 0.028
0.942MetPro: 0.942 ± 0.03
0.81MetGln: 0.81 ± 0.025
0.878MetArg: 0.878 ± 0.027
1.38MetSer: 1.38 ± 0.031
1.128MetThr: 1.128 ± 0.032
1.651MetVal: 1.651 ± 0.039
0.172MetTrp: 0.172 ± 0.012
0.693MetTyr: 0.693 ± 0.022
0.0MetXaa: 0.0 ± 0.0
Asn
3.656AsnAla: 3.656 ± 0.059
0.395AsnCys: 0.395 ± 0.02
2.951AsnAsp: 2.951 ± 0.052
3.266AsnGlu: 3.266 ± 0.053
2.964AsnPhe: 2.964 ± 0.063
4.111AsnGly: 4.111 ± 0.067
1.045AsnHis: 1.045 ± 0.035
4.632AsnIle: 4.632 ± 0.065
4.04AsnLys: 4.04 ± 0.066
5.262AsnLeu: 5.262 ± 0.073
1.18AsnMet: 1.18 ± 0.028
3.543AsnAsn: 3.543 ± 0.072
2.618AsnPro: 2.618 ± 0.047
2.02AsnGln: 2.02 ± 0.046
2.21AsnArg: 2.21 ± 0.045
3.704AsnSer: 3.704 ± 0.06
3.717AsnThr: 3.717 ± 0.064
3.13AsnVal: 3.13 ± 0.059
0.782AsnTrp: 0.782 ± 0.028
2.632AsnTyr: 2.632 ± 0.05
0.0AsnXaa: 0.0 ± 0.0
Pro
2.073ProAla: 2.073 ± 0.045
0.231ProCys: 0.231 ± 0.013
2.039ProAsp: 2.039 ± 0.043
2.838ProGlu: 2.838 ± 0.047
1.893ProPhe: 1.893 ± 0.036
2.173ProGly: 2.173 ± 0.046
0.714ProHis: 0.714 ± 0.026
2.777ProIle: 2.777 ± 0.047
2.793ProLys: 2.793 ± 0.05
3.357ProLeu: 3.357 ± 0.049
0.846ProMet: 0.846 ± 0.025
2.259ProAsn: 2.259 ± 0.051
0.956ProPro: 0.956 ± 0.038
1.211ProGln: 1.211 ± 0.037
1.055ProArg: 1.055 ± 0.031
2.463ProSer: 2.463 ± 0.048
2.052ProThr: 2.052 ± 0.04
2.374ProVal: 2.374 ± 0.045
0.397ProTrp: 0.397 ± 0.021
1.466ProTyr: 1.466 ± 0.037
0.0ProXaa: 0.0 ± 0.0
Gln
2.133GlnAla: 2.133 ± 0.041
0.181GlnCys: 0.181 ± 0.012
1.817GlnAsp: 1.817 ± 0.037
2.611GlnGlu: 2.611 ± 0.048
1.578GlnPhe: 1.578 ± 0.037
2.171GlnGly: 2.171 ± 0.041
0.683GlnHis: 0.683 ± 0.027
2.552GlnIle: 2.552 ± 0.052
2.839GlnLys: 2.839 ± 0.052
3.706GlnLeu: 3.706 ± 0.059
0.819GlnMet: 0.819 ± 0.027
2.018GlnAsn: 2.018 ± 0.043
1.093GlnPro: 1.093 ± 0.03
1.562GlnGln: 1.562 ± 0.041
1.34GlnArg: 1.34 ± 0.032
1.807GlnSer: 1.807 ± 0.043
1.628GlnThr: 1.628 ± 0.036
1.881GlnVal: 1.881 ± 0.041
0.486GlnTrp: 0.486 ± 0.02
1.435GlnTyr: 1.435 ± 0.037
0.0GlnXaa: 0.0 ± 0.0
Arg
2.217ArgAla: 2.217 ± 0.043
0.206ArgCys: 0.206 ± 0.013
1.874ArgAsp: 1.874 ± 0.044
2.425ArgGlu: 2.425 ± 0.05
1.924ArgPhe: 1.924 ± 0.045
2.108ArgGly: 2.108 ± 0.047
0.695ArgHis: 0.695 ± 0.024
2.939ArgIle: 2.939 ± 0.046
2.849ArgLys: 2.849 ± 0.051
3.514ArgLeu: 3.514 ± 0.06
0.911ArgMet: 0.911 ± 0.027
2.202ArgAsn: 2.202 ± 0.043
1.282ArgPro: 1.282 ± 0.033
1.158ArgGln: 1.158 ± 0.033
1.398ArgArg: 1.398 ± 0.037
2.082ArgSer: 2.082 ± 0.043
1.984ArgThr: 1.984 ± 0.042
2.167ArgVal: 2.167 ± 0.043
0.47ArgTrp: 0.47 ± 0.021
1.703ArgTyr: 1.703 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
3.729SerAla: 3.729 ± 0.054
0.655SerCys: 0.655 ± 0.026
3.442SerAsp: 3.442 ± 0.059
4.106SerGlu: 4.106 ± 0.063
3.898SerPhe: 3.898 ± 0.066
4.666SerGly: 4.666 ± 0.08
1.216SerHis: 1.216 ± 0.032
4.866SerIle: 4.866 ± 0.073
4.664SerLys: 4.664 ± 0.065
6.483SerLeu: 6.483 ± 0.083
1.413SerMet: 1.413 ± 0.032
3.388SerAsn: 3.388 ± 0.071
2.32SerPro: 2.32 ± 0.039
2.136SerGln: 2.136 ± 0.039
2.271SerArg: 2.271 ± 0.041
4.275SerSer: 4.275 ± 0.083
3.314SerThr: 3.314 ± 0.058
3.877SerVal: 3.877 ± 0.064
0.796SerTrp: 0.796 ± 0.029
2.854SerTyr: 2.854 ± 0.055
0.0SerXaa: 0.0 ± 0.0
Thr
4.092ThrAla: 4.092 ± 0.076
0.306ThrCys: 0.306 ± 0.017
3.352ThrAsp: 3.352 ± 0.064
3.364ThrGlu: 3.364 ± 0.061
2.78ThrPhe: 2.78 ± 0.042
3.989ThrGly: 3.989 ± 0.067
1.05ThrHis: 1.05 ± 0.028
4.636ThrIle: 4.636 ± 0.073
3.663ThrLys: 3.663 ± 0.059
5.305ThrLeu: 5.305 ± 0.067
1.082ThrMet: 1.082 ± 0.029
3.075ThrAsn: 3.075 ± 0.054
2.572ThrPro: 2.572 ± 0.045
1.816ThrGln: 1.816 ± 0.041
1.666ThrArg: 1.666 ± 0.035
3.662ThrSer: 3.662 ± 0.058
3.498ThrThr: 3.498 ± 0.064
3.78ThrVal: 3.78 ± 0.066
0.557ThrTrp: 0.557 ± 0.019
2.352ThrTyr: 2.352 ± 0.055
0.0ThrXaa: 0.0 ± 0.0
Val
4.463ValAla: 4.463 ± 0.075
0.506ValCys: 0.506 ± 0.023
3.453ValAsp: 3.453 ± 0.051
3.458ValGlu: 3.458 ± 0.058
3.458ValPhe: 3.458 ± 0.057
3.935ValGly: 3.935 ± 0.06
1.153ValHis: 1.153 ± 0.037
4.44ValIle: 4.44 ± 0.064
4.101ValLys: 4.101 ± 0.067
6.43ValLeu: 6.43 ± 0.09
1.366ValMet: 1.366 ± 0.033
3.35ValAsn: 3.35 ± 0.056
2.397ValPro: 2.397 ± 0.047
1.963ValGln: 1.963 ± 0.041
2.144ValArg: 2.144 ± 0.048
4.505ValSer: 4.505 ± 0.072
3.45ValThr: 3.45 ± 0.063
4.42ValVal: 4.42 ± 0.071
0.641ValTrp: 0.641 ± 0.022
2.319ValTyr: 2.319 ± 0.041
0.0ValXaa: 0.0 ± 0.0
Trp
0.672TrpAla: 0.672 ± 0.024
0.106TrpCys: 0.106 ± 0.01
0.675TrpAsp: 0.675 ± 0.027
0.818TrpGlu: 0.818 ± 0.027
0.577TrpPhe: 0.577 ± 0.021
0.828TrpGly: 0.828 ± 0.026
0.287TrpHis: 0.287 ± 0.016
0.741TrpIle: 0.741 ± 0.028
0.839TrpLys: 0.839 ± 0.024
1.063TrpLeu: 1.063 ± 0.027
0.328TrpMet: 0.328 ± 0.018
0.667TrpAsn: 0.667 ± 0.025
0.32TrpPro: 0.32 ± 0.016
0.433TrpGln: 0.433 ± 0.021
0.466TrpArg: 0.466 ± 0.02
0.713TrpSer: 0.713 ± 0.026
0.577TrpThr: 0.577 ± 0.021
0.68TrpVal: 0.68 ± 0.024
0.161TrpTrp: 0.161 ± 0.012
0.458TrpTyr: 0.458 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.474TyrAla: 2.474 ± 0.048
0.311TyrCys: 0.311 ± 0.016
2.325TyrAsp: 2.325 ± 0.043
2.28TyrGlu: 2.28 ± 0.045
2.424TyrPhe: 2.424 ± 0.051
2.844TyrGly: 2.844 ± 0.051
0.886TyrHis: 0.886 ± 0.027
2.561TyrIle: 2.561 ± 0.05
2.889TyrLys: 2.889 ± 0.05
3.745TyrLeu: 3.745 ± 0.056
0.763TyrMet: 0.763 ± 0.028
2.462TyrAsn: 2.462 ± 0.046
1.541TyrPro: 1.541 ± 0.036
1.618TyrGln: 1.618 ± 0.045
1.786TyrArg: 1.786 ± 0.037
2.736TyrSer: 2.736 ± 0.058
2.458TyrThr: 2.458 ± 0.06
2.116TyrVal: 2.116 ± 0.038
0.531TyrTrp: 0.531 ± 0.022
1.797TyrTyr: 1.797 ± 0.043
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3553 proteins (1230055 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski