Amino acid dipepetide frequency for Streptococcus phage Javan213

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.551AlaAla: 5.551 ± 1.089
0.52AlaCys: 0.52 ± 0.206
5.464AlaAsp: 5.464 ± 0.677
5.811AlaGlu: 5.811 ± 1.007
3.122AlaPhe: 3.122 ± 0.548
5.984AlaGly: 5.984 ± 0.839
1.214AlaHis: 1.214 ± 0.323
6.071AlaIle: 6.071 ± 1.201
5.724AlaLys: 5.724 ± 0.658
4.944AlaLeu: 4.944 ± 0.879
1.995AlaMet: 1.995 ± 0.427
5.291AlaAsn: 5.291 ± 1.012
2.082AlaPro: 2.082 ± 0.377
4.25AlaGln: 4.25 ± 0.665
2.775AlaArg: 2.775 ± 0.445
5.291AlaSer: 5.291 ± 0.882
5.551AlaThr: 5.551 ± 0.769
5.811AlaVal: 5.811 ± 0.728
1.474AlaTrp: 1.474 ± 0.488
2.602AlaTyr: 2.602 ± 0.405
0.0AlaXaa: 0.0 ± 0.0
Cys
0.173CysAla: 0.173 ± 0.136
0.0CysCys: 0.0 ± 0.0
0.694CysAsp: 0.694 ± 0.24
0.867CysGlu: 0.867 ± 0.312
0.173CysPhe: 0.173 ± 0.122
0.347CysGly: 0.347 ± 0.174
0.0CysHis: 0.0 ± 0.0
0.26CysIle: 0.26 ± 0.148
0.52CysLys: 0.52 ± 0.266
0.607CysLeu: 0.607 ± 0.254
0.0CysMet: 0.0 ± 0.0
0.173CysAsn: 0.173 ± 0.166
0.173CysPro: 0.173 ± 0.123
0.347CysGln: 0.347 ± 0.16
0.347CysArg: 0.347 ± 0.19
0.173CysSer: 0.173 ± 0.123
0.347CysThr: 0.347 ± 0.186
0.347CysVal: 0.347 ± 0.174
0.0CysTrp: 0.0 ± 0.0
0.173CysTyr: 0.173 ± 0.126
0.0CysXaa: 0.0 ± 0.0
Asp
4.337AspAla: 4.337 ± 0.586
0.52AspCys: 0.52 ± 0.217
4.51AspAsp: 4.51 ± 0.474
5.03AspGlu: 5.03 ± 0.867
3.643AspPhe: 3.643 ± 0.514
4.51AspGly: 4.51 ± 0.822
0.26AspHis: 0.26 ± 0.15
3.209AspIle: 3.209 ± 0.514
5.03AspLys: 5.03 ± 0.826
6.505AspLeu: 6.505 ± 0.731
1.648AspMet: 1.648 ± 0.38
3.643AspAsn: 3.643 ± 0.585
1.821AspPro: 1.821 ± 0.452
1.388AspGln: 1.388 ± 0.428
1.995AspArg: 1.995 ± 0.434
3.816AspSer: 3.816 ± 0.443
3.816AspThr: 3.816 ± 0.436
3.729AspVal: 3.729 ± 0.754
0.954AspTrp: 0.954 ± 0.232
3.729AspTyr: 3.729 ± 0.744
0.0AspXaa: 0.0 ± 0.0
Glu
5.637GluAla: 5.637 ± 1.032
0.434GluCys: 0.434 ± 0.21
5.204GluAsp: 5.204 ± 0.889
5.898GluGlu: 5.898 ± 1.046
2.515GluPhe: 2.515 ± 0.589
2.602GluGly: 2.602 ± 0.478
1.388GluHis: 1.388 ± 0.394
6.158GluIle: 6.158 ± 0.777
5.03GluLys: 5.03 ± 0.822
7.632GluLeu: 7.632 ± 1.131
2.168GluMet: 2.168 ± 0.458
3.209GluAsn: 3.209 ± 0.518
1.648GluPro: 1.648 ± 0.318
3.122GluGln: 3.122 ± 0.463
3.643GluArg: 3.643 ± 0.638
4.076GluSer: 4.076 ± 0.637
3.556GluThr: 3.556 ± 0.623
4.51GluVal: 4.51 ± 0.736
0.867GluTrp: 0.867 ± 0.336
3.122GluTyr: 3.122 ± 0.534
0.0GluXaa: 0.0 ± 0.0
Phe
1.995PheAla: 1.995 ± 0.539
0.173PheCys: 0.173 ± 0.115
3.122PheAsp: 3.122 ± 0.533
4.337PheGlu: 4.337 ± 0.747
1.648PhePhe: 1.648 ± 0.383
3.296PheGly: 3.296 ± 0.56
0.347PheHis: 0.347 ± 0.218
1.908PheIle: 1.908 ± 0.378
4.51PheLys: 4.51 ± 0.575
2.255PheLeu: 2.255 ± 0.401
1.041PheMet: 1.041 ± 0.308
2.515PheAsn: 2.515 ± 0.54
0.607PhePro: 0.607 ± 0.227
1.388PheGln: 1.388 ± 0.42
1.821PheArg: 1.821 ± 0.44
2.602PheSer: 2.602 ± 0.563
1.735PheThr: 1.735 ± 0.333
1.908PheVal: 1.908 ± 0.52
0.347PheTrp: 0.347 ± 0.144
1.388PheTyr: 1.388 ± 0.33
0.0PheXaa: 0.0 ± 0.0
Gly
5.464GlyAla: 5.464 ± 0.828
0.173GlyCys: 0.173 ± 0.119
2.255GlyAsp: 2.255 ± 0.48
3.903GlyGlu: 3.903 ± 0.49
2.515GlyPhe: 2.515 ± 0.561
3.469GlyGly: 3.469 ± 0.557
0.954GlyHis: 0.954 ± 0.241
4.597GlyIle: 4.597 ± 0.791
5.724GlyLys: 5.724 ± 0.697
5.204GlyLeu: 5.204 ± 1.13
2.168GlyMet: 2.168 ± 0.532
5.204GlyAsn: 5.204 ± 0.836
0.52GlyPro: 0.52 ± 0.335
2.515GlyGln: 2.515 ± 0.653
2.342GlyArg: 2.342 ± 0.409
4.51GlySer: 4.51 ± 0.678
3.556GlyThr: 3.556 ± 0.596
4.25GlyVal: 4.25 ± 0.641
0.867GlyTrp: 0.867 ± 0.288
2.689GlyTyr: 2.689 ± 0.419
0.0GlyXaa: 0.0 ± 0.0
His
0.954HisAla: 0.954 ± 0.249
0.347HisCys: 0.347 ± 0.244
0.781HisAsp: 0.781 ± 0.285
0.607HisGlu: 0.607 ± 0.255
0.607HisPhe: 0.607 ± 0.198
1.214HisGly: 1.214 ± 0.369
0.173HisHis: 0.173 ± 0.116
0.781HisIle: 0.781 ± 0.292
0.607HisLys: 0.607 ± 0.204
0.694HisLeu: 0.694 ± 0.198
0.347HisMet: 0.347 ± 0.231
0.954HisAsn: 0.954 ± 0.266
0.347HisPro: 0.347 ± 0.141
0.173HisGln: 0.173 ± 0.165
0.173HisArg: 0.173 ± 0.102
0.52HisSer: 0.52 ± 0.24
0.954HisThr: 0.954 ± 0.267
0.781HisVal: 0.781 ± 0.24
0.26HisTrp: 0.26 ± 0.141
0.607HisTyr: 0.607 ± 0.22
0.0HisXaa: 0.0 ± 0.0
Ile
6.071IleAla: 6.071 ± 1.037
0.347IleCys: 0.347 ± 0.141
4.597IleAsp: 4.597 ± 0.666
5.117IleGlu: 5.117 ± 0.954
1.908IlePhe: 1.908 ± 0.363
3.122IleGly: 3.122 ± 0.555
0.434IleHis: 0.434 ± 0.184
5.291IleIle: 5.291 ± 0.724
4.77IleLys: 4.77 ± 0.698
4.857IleLeu: 4.857 ± 0.646
0.954IleMet: 0.954 ± 0.383
3.382IleAsn: 3.382 ± 0.476
1.301IlePro: 1.301 ± 0.316
3.209IleGln: 3.209 ± 0.406
2.862IleArg: 2.862 ± 0.548
3.643IleSer: 3.643 ± 0.606
3.556IleThr: 3.556 ± 0.555
2.949IleVal: 2.949 ± 0.653
1.041IleTrp: 1.041 ± 0.324
2.255IleTyr: 2.255 ± 0.5
0.0IleXaa: 0.0 ± 0.0
Lys
7.112LysAla: 7.112 ± 0.829
0.434LysCys: 0.434 ± 0.225
4.77LysAsp: 4.77 ± 0.728
6.418LysGlu: 6.418 ± 0.988
2.775LysPhe: 2.775 ± 0.542
4.77LysGly: 4.77 ± 0.615
0.781LysHis: 0.781 ± 0.307
3.729LysIle: 3.729 ± 0.567
5.724LysLys: 5.724 ± 1.101
4.944LysLeu: 4.944 ± 0.571
2.082LysMet: 2.082 ± 0.557
4.683LysAsn: 4.683 ± 0.625
2.428LysPro: 2.428 ± 0.492
4.683LysGln: 4.683 ± 0.553
5.291LysArg: 5.291 ± 0.786
4.163LysSer: 4.163 ± 0.476
5.464LysThr: 5.464 ± 0.705
5.03LysVal: 5.03 ± 0.707
1.214LysTrp: 1.214 ± 0.365
2.602LysTyr: 2.602 ± 0.489
0.0LysXaa: 0.0 ± 0.0
Leu
7.285LeuAla: 7.285 ± 0.835
0.347LeuCys: 0.347 ± 0.267
5.551LeuAsp: 5.551 ± 0.704
5.984LeuGlu: 5.984 ± 0.754
2.168LeuPhe: 2.168 ± 0.386
5.117LeuGly: 5.117 ± 0.786
0.954LeuHis: 0.954 ± 0.291
4.337LeuIle: 4.337 ± 0.603
8.153LeuLys: 8.153 ± 1.08
6.158LeuLeu: 6.158 ± 0.719
1.648LeuMet: 1.648 ± 0.389
5.291LeuAsn: 5.291 ± 0.612
2.168LeuPro: 2.168 ± 0.423
2.862LeuGln: 2.862 ± 0.565
2.775LeuArg: 2.775 ± 0.39
5.898LeuSer: 5.898 ± 0.748
5.637LeuThr: 5.637 ± 0.952
4.25LeuVal: 4.25 ± 0.565
1.127LeuTrp: 1.127 ± 0.418
2.862LeuTyr: 2.862 ± 0.587
0.0LeuXaa: 0.0 ± 0.0
Met
2.862MetAla: 2.862 ± 0.653
0.087MetCys: 0.087 ± 0.082
1.041MetAsp: 1.041 ± 0.292
1.214MetGlu: 1.214 ± 0.361
0.867MetPhe: 0.867 ± 0.223
1.041MetGly: 1.041 ± 0.322
0.434MetHis: 0.434 ± 0.228
1.214MetIle: 1.214 ± 0.313
2.255MetLys: 2.255 ± 0.436
2.082MetLeu: 2.082 ± 0.334
0.434MetMet: 0.434 ± 0.178
1.041MetAsn: 1.041 ± 0.415
1.041MetPro: 1.041 ± 0.299
1.648MetGln: 1.648 ± 0.387
1.214MetArg: 1.214 ± 0.4
1.041MetSer: 1.041 ± 0.31
2.255MetThr: 2.255 ± 0.432
1.127MetVal: 1.127 ± 0.248
0.0MetTrp: 0.0 ± 0.0
0.434MetTyr: 0.434 ± 0.19
0.0MetXaa: 0.0 ± 0.0
Asn
3.99AsnAla: 3.99 ± 0.631
0.087AsnCys: 0.087 ± 0.088
3.122AsnAsp: 3.122 ± 0.554
3.382AsnGlu: 3.382 ± 0.505
2.168AsnPhe: 2.168 ± 0.377
7.025AsnGly: 7.025 ± 0.91
0.867AsnHis: 0.867 ± 0.249
2.689AsnIle: 2.689 ± 0.639
3.816AsnLys: 3.816 ± 0.525
4.944AsnLeu: 4.944 ± 0.87
1.041AsnMet: 1.041 ± 0.356
2.602AsnAsn: 2.602 ± 0.44
1.995AsnPro: 1.995 ± 0.333
3.382AsnGln: 3.382 ± 0.743
2.082AsnArg: 2.082 ± 0.378
4.163AsnSer: 4.163 ± 0.807
3.816AsnThr: 3.816 ± 0.758
4.163AsnVal: 4.163 ± 0.896
0.694AsnTrp: 0.694 ± 0.255
2.862AsnTyr: 2.862 ± 0.416
0.0AsnXaa: 0.0 ± 0.0
Pro
2.428ProAla: 2.428 ± 0.38
0.26ProCys: 0.26 ± 0.159
1.648ProAsp: 1.648 ± 0.366
1.821ProGlu: 1.821 ± 0.431
1.388ProPhe: 1.388 ± 0.384
0.867ProGly: 0.867 ± 0.283
0.52ProHis: 0.52 ± 0.264
1.648ProIle: 1.648 ± 0.373
1.388ProLys: 1.388 ± 0.366
1.474ProLeu: 1.474 ± 0.364
0.26ProMet: 0.26 ± 0.143
1.735ProAsn: 1.735 ± 0.454
0.52ProPro: 0.52 ± 0.215
1.041ProGln: 1.041 ± 0.302
0.867ProArg: 0.867 ± 0.31
1.735ProSer: 1.735 ± 0.301
1.908ProThr: 1.908 ± 0.394
1.995ProVal: 1.995 ± 0.383
0.347ProTrp: 0.347 ± 0.172
1.214ProTyr: 1.214 ± 0.343
0.0ProXaa: 0.0 ± 0.0
Gln
3.903GlnAla: 3.903 ± 0.98
0.173GlnCys: 0.173 ± 0.111
1.821GlnAsp: 1.821 ± 0.406
2.862GlnGlu: 2.862 ± 0.507
2.602GlnPhe: 2.602 ± 0.503
2.689GlnGly: 2.689 ± 0.581
0.26GlnHis: 0.26 ± 0.141
3.382GlnIle: 3.382 ± 0.53
3.209GlnLys: 3.209 ± 0.563
5.117GlnLeu: 5.117 ± 0.702
0.781GlnMet: 0.781 ± 0.253
1.995GlnAsn: 1.995 ± 0.442
1.127GlnPro: 1.127 ± 0.323
2.342GlnGln: 2.342 ± 0.6
2.168GlnArg: 2.168 ± 0.413
2.515GlnSer: 2.515 ± 0.4
3.729GlnThr: 3.729 ± 0.787
2.862GlnVal: 2.862 ± 0.683
0.347GlnTrp: 0.347 ± 0.188
1.561GlnTyr: 1.561 ± 0.457
0.0GlnXaa: 0.0 ± 0.0
Arg
4.337ArgAla: 4.337 ± 0.526
0.434ArgCys: 0.434 ± 0.193
1.821ArgAsp: 1.821 ± 0.487
2.689ArgGlu: 2.689 ± 0.558
1.735ArgPhe: 1.735 ± 0.297
1.821ArgGly: 1.821 ± 0.362
0.694ArgHis: 0.694 ± 0.298
2.602ArgIle: 2.602 ± 0.562
3.209ArgLys: 3.209 ± 0.561
3.816ArgLeu: 3.816 ± 0.475
1.388ArgMet: 1.388 ± 0.367
2.515ArgAsn: 2.515 ± 0.406
0.52ArgPro: 0.52 ± 0.183
1.735ArgGln: 1.735 ± 0.39
2.255ArgArg: 2.255 ± 0.458
1.821ArgSer: 1.821 ± 0.445
2.255ArgThr: 2.255 ± 0.377
2.949ArgVal: 2.949 ± 0.506
0.52ArgTrp: 0.52 ± 0.195
2.255ArgTyr: 2.255 ± 0.437
0.0ArgXaa: 0.0 ± 0.0
Ser
5.898SerAla: 5.898 ± 0.946
0.173SerCys: 0.173 ± 0.122
4.683SerAsp: 4.683 ± 0.88
4.423SerGlu: 4.423 ± 0.537
2.602SerPhe: 2.602 ± 0.421
4.77SerGly: 4.77 ± 0.789
0.434SerHis: 0.434 ± 0.18
3.122SerIle: 3.122 ± 0.389
4.51SerLys: 4.51 ± 0.64
5.291SerLeu: 5.291 ± 0.874
1.041SerMet: 1.041 ± 0.351
3.469SerAsn: 3.469 ± 0.608
1.214SerPro: 1.214 ± 0.334
3.296SerGln: 3.296 ± 0.525
1.735SerArg: 1.735 ± 0.392
4.25SerSer: 4.25 ± 0.867
4.337SerThr: 4.337 ± 0.824
4.337SerVal: 4.337 ± 0.566
0.867SerTrp: 0.867 ± 0.324
2.949SerTyr: 2.949 ± 0.498
0.0SerXaa: 0.0 ± 0.0
Thr
5.377ThrAla: 5.377 ± 1.37
0.347ThrCys: 0.347 ± 0.163
4.163ThrAsp: 4.163 ± 0.957
4.337ThrGlu: 4.337 ± 0.664
2.949ThrPhe: 2.949 ± 0.508
3.903ThrGly: 3.903 ± 0.519
0.694ThrHis: 0.694 ± 0.204
3.729ThrIle: 3.729 ± 0.605
5.291ThrLys: 5.291 ± 0.724
4.857ThrLeu: 4.857 ± 0.747
1.388ThrMet: 1.388 ± 0.319
2.862ThrAsn: 2.862 ± 0.346
2.689ThrPro: 2.689 ± 0.568
2.949ThrGln: 2.949 ± 0.501
1.908ThrArg: 1.908 ± 0.444
4.423ThrSer: 4.423 ± 0.969
5.377ThrThr: 5.377 ± 1.22
5.117ThrVal: 5.117 ± 0.732
0.781ThrTrp: 0.781 ± 0.228
2.775ThrTyr: 2.775 ± 0.591
0.0ThrXaa: 0.0 ± 0.0
Val
4.944ValAla: 4.944 ± 0.682
0.52ValCys: 0.52 ± 0.211
5.03ValAsp: 5.03 ± 0.698
4.163ValGlu: 4.163 ± 0.857
2.082ValPhe: 2.082 ± 0.328
3.643ValGly: 3.643 ± 0.501
0.694ValHis: 0.694 ± 0.193
3.643ValIle: 3.643 ± 0.623
5.117ValLys: 5.117 ± 0.69
4.77ValLeu: 4.77 ± 0.803
1.127ValMet: 1.127 ± 0.293
4.337ValAsn: 4.337 ± 0.679
1.908ValPro: 1.908 ± 0.391
1.908ValGln: 1.908 ± 0.345
2.602ValArg: 2.602 ± 0.475
4.857ValSer: 4.857 ± 0.794
4.77ValThr: 4.77 ± 0.699
4.683ValVal: 4.683 ± 0.717
0.694ValTrp: 0.694 ± 0.19
2.255ValTyr: 2.255 ± 0.4
0.0ValXaa: 0.0 ± 0.0
Trp
0.867TrpAla: 0.867 ± 0.231
0.173TrpCys: 0.173 ± 0.103
0.52TrpAsp: 0.52 ± 0.193
0.52TrpGlu: 0.52 ± 0.213
0.52TrpPhe: 0.52 ± 0.201
0.52TrpGly: 0.52 ± 0.196
0.173TrpHis: 0.173 ± 0.127
0.694TrpIle: 0.694 ± 0.248
1.388TrpLys: 1.388 ± 0.293
1.388TrpLeu: 1.388 ± 0.469
0.087TrpMet: 0.087 ± 0.076
1.301TrpAsn: 1.301 ± 0.456
0.0TrpPro: 0.0 ± 0.0
1.388TrpGln: 1.388 ± 0.404
0.694TrpArg: 0.694 ± 0.241
0.954TrpSer: 0.954 ± 0.278
0.954TrpThr: 0.954 ± 0.3
0.52TrpVal: 0.52 ± 0.185
0.0TrpTrp: 0.0 ± 0.0
0.607TrpTyr: 0.607 ± 0.244
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.342TyrAla: 2.342 ± 0.567
0.173TyrCys: 0.173 ± 0.132
3.296TyrAsp: 3.296 ± 0.649
3.036TyrGlu: 3.036 ± 0.668
0.954TyrPhe: 0.954 ± 0.243
2.168TyrGly: 2.168 ± 0.469
0.607TyrHis: 0.607 ± 0.187
2.689TyrIle: 2.689 ± 0.389
3.122TyrLys: 3.122 ± 0.586
3.036TyrLeu: 3.036 ± 0.47
1.648TyrMet: 1.648 ± 0.311
2.689TyrAsn: 2.689 ± 0.456
0.954TyrPro: 0.954 ± 0.264
1.821TyrGln: 1.821 ± 0.467
1.821TyrArg: 1.821 ± 0.398
2.949TyrSer: 2.949 ± 0.662
2.342TyrThr: 2.342 ± 0.679
2.428TyrVal: 2.428 ± 0.431
0.867TyrTrp: 0.867 ± 0.276
1.821TyrTyr: 1.821 ± 0.335
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 55 proteins (11531 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski