Amino acid dipepetide frequency for Jannaschia aquimarina

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	18.597AlaAla: 18.597 ± 0.184	1.244AlaCys: 1.244 ± 0.035	7.798AlaAsp: 7.798 ± 0.095	8.67AlaGlu: 8.67 ± 0.121	4.731AlaPhe: 4.731 ± 0.066	11.288AlaGly: 11.288 ± 0.114	2.366AlaHis: 2.366 ± 0.052	6.196AlaIle: 6.196 ± 0.08	2.854AlaLys: 2.854 ± 0.054	14.439AlaLeu: 14.439 ± 0.143	3.935AlaMet: 3.935 ± 0.057	2.398AlaAsn: 2.398 ± 0.043	6.687AlaPro: 6.687 ± 0.111	3.99AlaGln: 3.99 ± 0.066	10.448AlaArg: 10.448 ± 0.138	5.904AlaSer: 5.904 ± 0.069	6.505AlaThr: 6.505 ± 0.084	8.86AlaVal: 8.86 ± 0.091	1.816AlaTrp: 1.816 ± 0.045	2.401AlaTyr: 2.401 ± 0.049	0.0AlaXaa: 0.0 ± 0.0
Cys	1.099CysAla: 1.099 ± 0.035	0.085CysCys: 0.085 ± 0.008	0.608CysAsp: 0.608 ± 0.022	0.453CysGlu: 0.453 ± 0.019	0.291CysPhe: 0.291 ± 0.016	0.94CysGly: 0.94 ± 0.032	0.245CysHis: 0.245 ± 0.012	0.354CysIle: 0.354 ± 0.018	0.146CysLys: 0.146 ± 0.011	0.846CysLeu: 0.846 ± 0.027	0.167CysMet: 0.167 ± 0.012	0.182CysAsn: 0.182 ± 0.013	0.482CysPro: 0.482 ± 0.021	0.188CysGln: 0.188 ± 0.012	0.618CysArg: 0.618 ± 0.024	0.38CysSer: 0.38 ± 0.019	0.425CysThr: 0.425 ± 0.02	0.642CysVal: 0.642 ± 0.023	0.109CysTrp: 0.109 ± 0.01	0.182CysTyr: 0.182 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	8.581AspAla: 8.581 ± 0.109	0.475AspCys: 0.475 ± 0.019	4.084AspAsp: 4.084 ± 0.107	3.851AspGlu: 3.851 ± 0.065	2.165AspPhe: 2.165 ± 0.042	6.926AspGly: 6.926 ± 0.118	1.476AspHis: 1.476 ± 0.041	2.741AspIle: 2.741 ± 0.054	1.156AspLys: 1.156 ± 0.035	7.401AspLeu: 7.401 ± 0.095	1.494AspMet: 1.494 ± 0.036	0.968AspAsn: 0.968 ± 0.031	4.558AspPro: 4.558 ± 0.075	1.613AspGln: 1.613 ± 0.039	5.582AspArg: 5.582 ± 0.077	1.832AspSer: 1.832 ± 0.037	2.934AspThr: 2.934 ± 0.061	4.689AspVal: 4.689 ± 0.063	1.356AspTrp: 1.356 ± 0.033	1.386AspTyr: 1.386 ± 0.033	0.0AspXaa: 0.0 ± 0.0
Glu	9.295GluAla: 9.295 ± 0.122	0.366GluCys: 0.366 ± 0.018	3.657GluAsp: 3.657 ± 0.057	3.874GluGlu: 3.874 ± 0.078	1.644GluPhe: 1.644 ± 0.032	5.614GluGly: 5.614 ± 0.073	1.036GluHis: 1.036 ± 0.035	3.494GluIle: 3.494 ± 0.061	1.586GluLys: 1.586 ± 0.042	4.754GluLeu: 4.754 ± 0.065	1.926GluMet: 1.926 ± 0.034	1.422GluAsn: 1.422 ± 0.037	2.737GluPro: 2.737 ± 0.057	1.727GluGln: 1.727 ± 0.043	5.067GluArg: 5.067 ± 0.075	2.072GluSer: 2.072 ± 0.046	3.994GluThr: 3.994 ± 0.06	4.616GluVal: 4.616 ± 0.058	0.808GluTrp: 0.808 ± 0.024	0.957GluTyr: 0.957 ± 0.032	0.0GluXaa: 0.0 ± 0.0
Phe	4.586PheAla: 4.586 ± 0.068	0.353PheCys: 0.353 ± 0.015	2.792PheAsp: 2.792 ± 0.046	2.234PheGlu: 2.234 ± 0.044	1.226PhePhe: 1.226 ± 0.032	3.622PheGly: 3.622 ± 0.061	0.682PheHis: 0.682 ± 0.024	1.26PheIle: 1.26 ± 0.032	0.633PheLys: 0.633 ± 0.025	3.331PheLeu: 3.331 ± 0.071	0.721PheMet: 0.721 ± 0.025	0.758PheAsn: 0.758 ± 0.025	1.515PhePro: 1.515 ± 0.038	0.883PheGln: 0.883 ± 0.027	2.362PheArg: 2.362 ± 0.044	1.701PheSer: 1.701 ± 0.046	1.938PheThr: 1.938 ± 0.044	2.794PheVal: 2.794 ± 0.052	0.582PheTrp: 0.582 ± 0.023	0.813PheTyr: 0.813 ± 0.027	0.0PheXaa: 0.0 ± 0.0
Gly	10.82GlyAla: 10.82 ± 0.138	0.845GlyCys: 0.845 ± 0.027	5.41GlyAsp: 5.41 ± 0.106	5.251GlyGlu: 5.251 ± 0.072	3.559GlyPhe: 3.559 ± 0.061	8.369GlyGly: 8.369 ± 0.129	1.98GlyHis: 1.98 ± 0.047	4.348GlyIle: 4.348 ± 0.061	2.413GlyLys: 2.413 ± 0.051	9.849GlyLeu: 9.849 ± 0.103	2.507GlyMet: 2.507 ± 0.044	1.871GlyAsn: 1.871 ± 0.051	4.436GlyPro: 4.436 ± 0.063	2.867GlyGln: 2.867 ± 0.053	7.057GlyArg: 7.057 ± 0.08	4.211GlySer: 4.211 ± 0.072	5.353GlyThr: 5.353 ± 0.084	6.261GlyVal: 6.261 ± 0.075	1.691GlyTrp: 1.691 ± 0.038	2.138GlyTyr: 2.138 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.444HisAla: 2.444 ± 0.047	0.214HisCys: 0.214 ± 0.014	1.355HisAsp: 1.355 ± 0.037	1.084HisGlu: 1.084 ± 0.032	0.722HisPhe: 0.722 ± 0.027	1.971HisGly: 1.971 ± 0.048	0.538HisHis: 0.538 ± 0.021	0.81HisIle: 0.81 ± 0.023	0.363HisLys: 0.363 ± 0.018	2.224HisLeu: 2.224 ± 0.049	0.485HisMet: 0.485 ± 0.019	0.347HisAsn: 0.347 ± 0.016	1.347HisPro: 1.347 ± 0.038	0.482HisGln: 0.482 ± 0.02	1.507HisArg: 1.507 ± 0.038	0.867HisSer: 0.867 ± 0.025	0.741HisThr: 0.741 ± 0.023	1.596HisVal: 1.596 ± 0.037	0.339HisTrp: 0.339 ± 0.017	0.448HisTyr: 0.448 ± 0.019	0.0HisXaa: 0.0 ± 0.0
Ile	6.819IleAla: 6.819 ± 0.084	0.536IleCys: 0.536 ± 0.022	3.422IleAsp: 3.422 ± 0.05	3.439IleGlu: 3.439 ± 0.059	1.513IlePhe: 1.513 ± 0.044	4.631IleGly: 4.631 ± 0.073	0.902IleHis: 0.902 ± 0.028	1.517IleIle: 1.517 ± 0.04	0.882IleLys: 0.882 ± 0.029	4.758IleLeu: 4.758 ± 0.067	0.849IleMet: 0.849 ± 0.028	0.908IleAsn: 0.908 ± 0.027	2.326IlePro: 2.326 ± 0.045	1.025IleGln: 1.025 ± 0.03	3.407IleArg: 3.407 ± 0.054	2.313IleSer: 2.313 ± 0.048	2.361IleThr: 2.361 ± 0.044	3.9IleVal: 3.9 ± 0.052	0.718IleTrp: 0.718 ± 0.027	0.98IleTyr: 0.98 ± 0.028	0.0IleXaa: 0.0 ± 0.0
Lys	3.071LysAla: 3.071 ± 0.058	0.132LysCys: 0.132 ± 0.011	1.317LysAsp: 1.317 ± 0.034	1.073LysGlu: 1.073 ± 0.035	0.59LysPhe: 0.59 ± 0.024	2.166LysGly: 2.166 ± 0.047	0.426LysHis: 0.426 ± 0.02	1.061LysIle: 1.061 ± 0.03	0.744LysLys: 0.744 ± 0.035	2.225LysLeu: 2.225 ± 0.043	0.588LysMet: 0.588 ± 0.023	0.471LysAsn: 0.471 ± 0.021	1.326LysPro: 1.326 ± 0.04	0.547LysGln: 0.547 ± 0.023	1.805LysArg: 1.805 ± 0.04	1.216LysSer: 1.216 ± 0.039	1.396LysThr: 1.396 ± 0.034	1.799LysVal: 1.799 ± 0.05	0.306LysTrp: 0.306 ± 0.014	0.426LysTyr: 0.426 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	13.723LeuAla: 13.723 ± 0.138	0.899LeuCys: 0.899 ± 0.029	6.849LeuAsp: 6.849 ± 0.083	5.351LeuGlu: 5.351 ± 0.073	3.351LeuPhe: 3.351 ± 0.058	8.63LeuGly: 8.63 ± 0.092	1.986LeuHis: 1.986 ± 0.04	4.868LeuIle: 4.868 ± 0.081	2.263LeuLys: 2.263 ± 0.051	9.149LeuLeu: 9.149 ± 0.11	2.527LeuMet: 2.527 ± 0.049	2.262LeuAsn: 2.262 ± 0.038	5.877LeuPro: 5.877 ± 0.076	2.309LeuGln: 2.309 ± 0.044	8.198LeuArg: 8.198 ± 0.1	6.637LeuSer: 6.637 ± 0.078	6.241LeuThr: 6.241 ± 0.081	7.099LeuVal: 7.099 ± 0.072	1.458LeuTrp: 1.458 ± 0.036	1.874LeuTyr: 1.874 ± 0.039	0.0LeuXaa: 0.0 ± 0.0
Met	3.386MetAla: 3.386 ± 0.055	0.161MetCys: 0.161 ± 0.012	1.441MetAsp: 1.441 ± 0.037	1.393MetGlu: 1.393 ± 0.034	0.694MetPhe: 0.694 ± 0.023	2.168MetGly: 2.168 ± 0.042	0.423MetHis: 0.423 ± 0.017	1.322MetIle: 1.322 ± 0.038	0.836MetLys: 0.836 ± 0.028	2.439MetLeu: 2.439 ± 0.049	0.667MetMet: 0.667 ± 0.025	0.689MetAsn: 0.689 ± 0.023	1.499MetPro: 1.499 ± 0.03	0.824MetGln: 0.824 ± 0.029	2.134MetArg: 2.134 ± 0.036	1.545MetSer: 1.545 ± 0.041	2.012MetThr: 2.012 ± 0.039	1.746MetVal: 1.746 ± 0.047	0.254MetTrp: 0.254 ± 0.013	0.288MetTyr: 0.288 ± 0.016	0.0MetXaa: 0.0 ± 0.0
Asn	2.828AsnAla: 2.828 ± 0.05	0.188AsnCys: 0.188 ± 0.012	1.241AsnAsp: 1.241 ± 0.04	1.016AsnGlu: 1.016 ± 0.029	0.716AsnPhe: 0.716 ± 0.03	2.06AsnGly: 2.06 ± 0.044	0.43AsnHis: 0.43 ± 0.02	0.927AsnIle: 0.927 ± 0.031	0.393AsnLys: 0.393 ± 0.019	2.16AsnLeu: 2.16 ± 0.045	0.507AsnMet: 0.507 ± 0.022	0.449AsnAsn: 0.449 ± 0.023	1.553AsnPro: 1.553 ± 0.041	0.54AsnGln: 0.54 ± 0.023	1.594AsnArg: 1.594 ± 0.04	0.87AsnSer: 0.87 ± 0.027	0.989AsnThr: 0.989 ± 0.034	1.715AsnVal: 1.715 ± 0.038	0.363AsnTrp: 0.363 ± 0.016	0.497AsnTyr: 0.497 ± 0.022	0.0AsnXaa: 0.0 ± 0.0
Pro	6.576ProAla: 6.576 ± 0.082	0.374ProCys: 0.374 ± 0.018	4.774ProAsp: 4.774 ± 0.077	4.236ProGlu: 4.236 ± 0.068	2.01ProPhe: 2.01 ± 0.037	5.086ProGly: 5.086 ± 0.074	1.102ProHis: 1.102 ± 0.035	2.253ProIle: 2.253 ± 0.046	1.301ProLys: 1.301 ± 0.04	4.907ProLeu: 4.907 ± 0.066	1.273ProMet: 1.273 ± 0.04	1.157ProAsn: 1.157 ± 0.03	2.88ProPro: 2.88 ± 0.054	1.477ProGln: 1.477 ± 0.037	3.425ProArg: 3.425 ± 0.064	2.728ProSer: 2.728 ± 0.051	2.625ProThr: 2.625 ± 0.047	4.508ProVal: 4.508 ± 0.062	0.799ProTrp: 0.799 ± 0.028	1.063ProTyr: 1.063 ± 0.031	0.0ProXaa: 0.0 ± 0.0
Gln	3.7GlnAla: 3.7 ± 0.054	0.191GlnCys: 0.191 ± 0.012	1.605GlnAsp: 1.605 ± 0.04	1.456GlnGlu: 1.456 ± 0.039	0.822GlnPhe: 0.822 ± 0.027	2.381GlnGly: 2.381 ± 0.047	0.462GlnHis: 0.462 ± 0.018	1.655GlnIle: 1.655 ± 0.036	0.696GlnLys: 0.696 ± 0.026	2.296GlnLeu: 2.296 ± 0.052	0.87GlnMet: 0.87 ± 0.03	0.668GlnAsn: 0.668 ± 0.021	1.46GlnPro: 1.46 ± 0.035	0.866GlnGln: 0.866 ± 0.034	1.985GlnArg: 1.985 ± 0.042	1.452GlnSer: 1.452 ± 0.04	1.633GlnThr: 1.633 ± 0.044	2.23GlnVal: 2.23 ± 0.043	0.358GlnTrp: 0.358 ± 0.016	0.455GlnTyr: 0.455 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	9.733ArgAla: 9.733 ± 0.098	0.524ArgCys: 0.524 ± 0.022	5.241ArgAsp: 5.241 ± 0.082	4.479ArgGlu: 4.479 ± 0.069	2.875ArgPhe: 2.875 ± 0.053	5.528ArgGly: 5.528 ± 0.072	1.647ArgHis: 1.647 ± 0.043	4.282ArgIle: 4.282 ± 0.073	1.914ArgLys: 1.914 ± 0.041	8.539ArgLeu: 8.539 ± 0.103	2.297ArgMet: 2.297 ± 0.046	1.651ArgAsn: 1.651 ± 0.038	4.116ArgPro: 4.116 ± 0.064	2.255ArgGln: 2.255 ± 0.05	6.351ArgArg: 6.351 ± 0.086	3.569ArgSer: 3.569 ± 0.061	3.815ArgThr: 3.815 ± 0.053	5.278ArgVal: 5.278 ± 0.081	1.137ArgTrp: 1.137 ± 0.031	1.575ArgTyr: 1.575 ± 0.037	0.0ArgXaa: 0.0 ± 0.0
Ser	5.647SerAla: 5.647 ± 0.069	0.372SerCys: 0.372 ± 0.023	3.397SerAsp: 3.397 ± 0.06	2.875SerGlu: 2.875 ± 0.056	1.867SerPhe: 1.867 ± 0.04	5.178SerGly: 5.178 ± 0.076	0.952SerHis: 0.952 ± 0.027	2.17SerIle: 2.17 ± 0.049	1.101SerLys: 1.101 ± 0.03	4.68SerLeu: 4.68 ± 0.073	1.196SerMet: 1.196 ± 0.034	1.137SerAsn: 1.137 ± 0.034	2.533SerPro: 2.533 ± 0.051	1.311SerGln: 1.311 ± 0.036	3.436SerArg: 3.436 ± 0.058	2.224SerSer: 2.224 ± 0.055	2.316SerThr: 2.316 ± 0.038	3.676SerVal: 3.676 ± 0.059	0.665SerTrp: 0.665 ± 0.023	1.072SerTyr: 1.072 ± 0.031	0.0SerXaa: 0.0 ± 0.0
Thr	6.302ThrAla: 6.302 ± 0.077	0.503ThrCys: 0.503 ± 0.022	3.485ThrAsp: 3.485 ± 0.064	3.093ThrGlu: 3.093 ± 0.048	2.054ThrPhe: 2.054 ± 0.043	5.689ThrGly: 5.689 ± 0.089	1.089ThrHis: 1.089 ± 0.034	2.74ThrIle: 2.74 ± 0.049	1.097ThrLys: 1.097 ± 0.038	6.211ThrLeu: 6.211 ± 0.09	1.233ThrMet: 1.233 ± 0.035	1.129ThrAsn: 1.129 ± 0.042	3.47ThrPro: 3.47 ± 0.053	1.336ThrGln: 1.336 ± 0.032	3.9ThrArg: 3.9 ± 0.053	2.571ThrSer: 2.571 ± 0.053	2.768ThrThr: 2.768 ± 0.063	4.343ThrVal: 4.343 ± 0.07	0.738ThrTrp: 0.738 ± 0.023	1.178ThrTyr: 1.178 ± 0.032	0.0ThrXaa: 0.0 ± 0.0
Val	9.903ValAla: 9.903 ± 0.098	0.633ValCys: 0.633 ± 0.021	4.363ValAsp: 4.363 ± 0.069	4.855ValGlu: 4.855 ± 0.066	2.652ValPhe: 2.652 ± 0.046	5.828ValGly: 5.828 ± 0.078	1.353ValHis: 1.353 ± 0.033	3.757ValIle: 3.757 ± 0.067	1.558ValLys: 1.558 ± 0.046	7.578ValLeu: 7.578 ± 0.098	1.861ValMet: 1.861 ± 0.042	1.731ValAsn: 1.731 ± 0.036	4.036ValPro: 4.036 ± 0.065	1.93ValGln: 1.93 ± 0.039	4.977ValArg: 4.977 ± 0.066	3.869ValSer: 3.869 ± 0.057	5.029ValThr: 5.029 ± 0.068	5.86ValVal: 5.86 ± 0.068	1.035ValTrp: 1.035 ± 0.025	1.255ValTyr: 1.255 ± 0.034	0.0ValXaa: 0.0 ± 0.0
Trp	1.535TrpAla: 1.535 ± 0.033	0.151TrpCys: 0.151 ± 0.012	0.936TrpAsp: 0.936 ± 0.03	0.756TrpGlu: 0.756 ± 0.028	0.583TrpPhe: 0.583 ± 0.02	1.13TrpGly: 1.13 ± 0.032	0.364TrpHis: 0.364 ± 0.018	0.781TrpIle: 0.781 ± 0.026	0.375TrpLys: 0.375 ± 0.019	1.787TrpLeu: 1.787 ± 0.043	0.42TrpMet: 0.42 ± 0.018	0.394TrpAsn: 0.394 ± 0.018	0.747TrpPro: 0.747 ± 0.022	0.547TrpGln: 0.547 ± 0.018	1.372TrpArg: 1.372 ± 0.03	0.878TrpSer: 0.878 ± 0.029	0.912TrpThr: 0.912 ± 0.027	0.958TrpVal: 0.958 ± 0.028	0.295TrpTrp: 0.295 ± 0.019	0.233TrpTyr: 0.233 ± 0.013	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.479TyrAla: 2.479 ± 0.046	0.199TyrCys: 0.199 ± 0.012	1.492TyrAsp: 1.492 ± 0.026	1.209TyrGlu: 1.209 ± 0.034	0.721TyrPhe: 0.721 ± 0.026	2.028TyrGly: 2.028 ± 0.042	0.425TyrHis: 0.425 ± 0.019	0.669TyrIle: 0.669 ± 0.021	0.376TyrLys: 0.376 ± 0.016	1.976TyrLeu: 1.976 ± 0.042	0.394TyrMet: 0.394 ± 0.017	0.447TyrAsn: 0.447 ± 0.019	0.97TyrPro: 0.97 ± 0.028	0.525TyrGln: 0.525 ± 0.024	1.578TyrArg: 1.578 ± 0.034	0.964TyrSer: 0.964 ± 0.03	0.943TyrThr: 0.943 ± 0.028	1.494TyrVal: 1.494 ± 0.034	0.332TyrTrp: 0.332 ± 0.016	0.453TyrTyr: 0.453 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4049 proteins (1221941 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---