Amino acid dipepetide frequency for Flavobacterium haoranii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	3.639AlaAla: 3.639 ± 0.09	0.547AlaCys: 0.547 ± 0.03	2.993AlaAsp: 2.993 ± 0.07	4.031AlaGlu: 4.031 ± 0.085	3.165AlaPhe: 3.165 ± 0.059	3.784AlaGly: 3.784 ± 0.084	0.957AlaHis: 0.957 ± 0.032	5.278AlaIle: 5.278 ± 0.079	4.979AlaLys: 4.979 ± 0.099	5.748AlaLeu: 5.748 ± 0.098	1.375AlaMet: 1.375 ± 0.043	3.595AlaAsn: 3.595 ± 0.077	1.792AlaPro: 1.792 ± 0.054	2.433AlaGln: 2.433 ± 0.053	1.735AlaArg: 1.735 ± 0.05	3.945AlaSer: 3.945 ± 0.078	3.837AlaThr: 3.837 ± 0.102	3.933AlaVal: 3.933 ± 0.082	0.536AlaTrp: 0.536 ± 0.026	2.148AlaTyr: 2.148 ± 0.062	0.0AlaXaa: 0.0 ± 0.0
Cys	0.42CysAla: 0.42 ± 0.023	0.096CysCys: 0.096 ± 0.011	0.449CysAsp: 0.449 ± 0.028	0.514CysGlu: 0.514 ± 0.027	0.423CysPhe: 0.423 ± 0.022	0.674CysGly: 0.674 ± 0.046	0.195CysHis: 0.195 ± 0.019	0.592CysIle: 0.592 ± 0.024	0.524CysLys: 0.524 ± 0.03	0.573CysLeu: 0.573 ± 0.025	0.132CysMet: 0.132 ± 0.013	0.496CysAsn: 0.496 ± 0.037	0.342CysPro: 0.342 ± 0.028	0.23CysGln: 0.23 ± 0.017	0.191CysArg: 0.191 ± 0.015	0.619CysSer: 0.619 ± 0.033	0.433CysThr: 0.433 ± 0.032	0.427CysVal: 0.427 ± 0.02	0.066CysTrp: 0.066 ± 0.009	0.319CysTyr: 0.319 ± 0.019	0.0CysXaa: 0.0 ± 0.0
Asp	3.332AspAla: 3.332 ± 0.067	0.482AspCys: 0.482 ± 0.036	2.655AspAsp: 2.655 ± 0.073	3.843AspGlu: 3.843 ± 0.073	3.826AspPhe: 3.826 ± 0.072	3.318AspGly: 3.318 ± 0.082	0.691AspHis: 0.691 ± 0.029	4.044AspIle: 4.044 ± 0.076	4.417AspLys: 4.417 ± 0.081	5.025AspLeu: 5.025 ± 0.078	0.992AspMet: 0.992 ± 0.031	3.254AspAsn: 3.254 ± 0.06	1.332AspPro: 1.332 ± 0.042	1.245AspGln: 1.245 ± 0.035	1.596AspArg: 1.596 ± 0.046	2.935AspSer: 2.935 ± 0.058	2.493AspThr: 2.493 ± 0.062	3.545AspVal: 3.545 ± 0.07	0.665AspTrp: 0.665 ± 0.03	2.809AspTyr: 2.809 ± 0.059	0.0AspXaa: 0.0 ± 0.0
Glu	4.209GluAla: 4.209 ± 0.089	0.374GluCys: 0.374 ± 0.024	3.262GluAsp: 3.262 ± 0.069	5.232GluGlu: 5.232 ± 0.102	3.351GluPhe: 3.351 ± 0.07	3.604GluGly: 3.604 ± 0.072	1.077GluHis: 1.077 ± 0.033	6.169GluIle: 6.169 ± 0.091	6.772GluLys: 6.772 ± 0.115	6.312GluLeu: 6.312 ± 0.12	1.708GluMet: 1.708 ± 0.045	5.606GluAsn: 5.606 ± 0.091	1.616GluPro: 1.616 ± 0.039	2.425GluGln: 2.425 ± 0.06	2.319GluArg: 2.319 ± 0.063	3.299GluSer: 3.299 ± 0.066	3.864GluThr: 3.864 ± 0.062	4.691GluVal: 4.691 ± 0.081	0.611GluTrp: 0.611 ± 0.026	2.505GluTyr: 2.505 ± 0.049	0.0GluXaa: 0.0 ± 0.0
Phe	3.113PheAla: 3.113 ± 0.058	0.486PheCys: 0.486 ± 0.025	3.395PheAsp: 3.395 ± 0.069	3.848PheGlu: 3.848 ± 0.076	3.042PhePhe: 3.042 ± 0.077	3.708PheGly: 3.708 ± 0.079	0.843PheHis: 0.843 ± 0.033	4.128PheIle: 4.128 ± 0.096	3.922PheLys: 3.922 ± 0.075	5.125PheLeu: 5.125 ± 0.092	1.136PheMet: 1.136 ± 0.036	3.644PheAsn: 3.644 ± 0.072	1.739PhePro: 1.739 ± 0.046	1.857PheGln: 1.857 ± 0.05	1.546PheArg: 1.546 ± 0.05	4.203PheSer: 4.203 ± 0.093	3.331PheThr: 3.331 ± 0.085	3.4PheVal: 3.4 ± 0.069	0.607PheTrp: 0.607 ± 0.029	2.544PheTyr: 2.544 ± 0.059	0.0PheXaa: 0.0 ± 0.0
Gly	3.873GlyAla: 3.873 ± 0.093	0.589GlyCys: 0.589 ± 0.036	2.944GlyAsp: 2.944 ± 0.07	3.458GlyGlu: 3.458 ± 0.077	3.616GlyPhe: 3.616 ± 0.071	4.265GlyGly: 4.265 ± 0.114	1.051GlyHis: 1.051 ± 0.032	5.276GlyIle: 5.276 ± 0.08	5.15GlyLys: 5.15 ± 0.087	5.403GlyLeu: 5.403 ± 0.081	1.553GlyMet: 1.553 ± 0.053	3.799GlyAsn: 3.799 ± 0.089	1.264GlyPro: 1.264 ± 0.048	1.78GlyGln: 1.78 ± 0.047	1.81GlyArg: 1.81 ± 0.055	3.822GlySer: 3.822 ± 0.1	4.093GlyThr: 4.093 ± 0.111	4.143GlyVal: 4.143 ± 0.087	0.618GlyTrp: 0.618 ± 0.029	2.745GlyTyr: 2.745 ± 0.055	0.0GlyXaa: 0.0 ± 0.0
His	0.873HisAla: 0.873 ± 0.031	0.164HisCys: 0.164 ± 0.014	0.802HisAsp: 0.802 ± 0.032	0.968HisGlu: 0.968 ± 0.032	1.206HisPhe: 1.206 ± 0.047	0.914HisGly: 0.914 ± 0.036	0.47HisHis: 0.47 ± 0.025	1.341HisIle: 1.341 ± 0.04	1.172HisLys: 1.172 ± 0.038	1.688HisLeu: 1.688 ± 0.052	0.288HisMet: 0.288 ± 0.017	0.989HisAsn: 0.989 ± 0.037	0.791HisPro: 0.791 ± 0.036	0.739HisGln: 0.739 ± 0.031	0.557HisArg: 0.557 ± 0.027	0.962HisSer: 0.962 ± 0.033	0.828HisThr: 0.828 ± 0.028	0.953HisVal: 0.953 ± 0.032	0.19HisTrp: 0.19 ± 0.013	0.858HisTyr: 0.858 ± 0.035	0.0HisXaa: 0.0 ± 0.0
Ile	5.481IleAla: 5.481 ± 0.093	0.632IleCys: 0.632 ± 0.029	4.907IleAsp: 4.907 ± 0.081	5.994IleGlu: 5.994 ± 0.101	3.964IlePhe: 3.964 ± 0.072	4.986IleGly: 4.986 ± 0.085	1.37IleHis: 1.37 ± 0.044	6.365IleIle: 6.365 ± 0.116	6.139IleLys: 6.139 ± 0.107	7.296IleLeu: 7.296 ± 0.116	1.372IleMet: 1.372 ± 0.038	5.043IleAsn: 5.043 ± 0.083	3.058IlePro: 3.058 ± 0.067	2.941IleGln: 2.941 ± 0.067	2.359IleArg: 2.359 ± 0.061	5.74IleSer: 5.74 ± 0.094	4.854IleThr: 4.854 ± 0.088	5.198IleVal: 5.198 ± 0.079	0.673IleTrp: 0.673 ± 0.029	2.973IleTyr: 2.973 ± 0.066	0.0IleXaa: 0.0 ± 0.0
Lys	4.911LysAla: 4.911 ± 0.089	0.393LysCys: 0.393 ± 0.021	4.327LysAsp: 4.327 ± 0.078	6.66LysGlu: 6.66 ± 0.135	3.493LysPhe: 3.493 ± 0.066	4.423LysGly: 4.423 ± 0.08	1.365LysHis: 1.365 ± 0.045	7.131LysIle: 7.131 ± 0.126	7.311LysLys: 7.311 ± 0.112	6.944LysLeu: 6.944 ± 0.103	2.26LysMet: 2.26 ± 0.054	5.853LysAsn: 5.853 ± 0.102	2.431LysPro: 2.431 ± 0.059	2.783LysGln: 2.783 ± 0.058	2.707LysArg: 2.707 ± 0.058	4.691LysSer: 4.691 ± 0.081	4.723LysThr: 4.723 ± 0.077	5.189LysVal: 5.189 ± 0.091	0.772LysTrp: 0.772 ± 0.033	3.261LysTyr: 3.261 ± 0.07	0.0LysXaa: 0.0 ± 0.0
Leu	5.755LeuAla: 5.755 ± 0.086	0.609LeuCys: 0.609 ± 0.031	4.788LeuAsp: 4.788 ± 0.084	6.296LeuGlu: 6.296 ± 0.099	5.212LeuPhe: 5.212 ± 0.111	5.6LeuGly: 5.6 ± 0.086	1.637LeuHis: 1.637 ± 0.046	6.928LeuIle: 6.928 ± 0.129	7.656LeuLys: 7.656 ± 0.118	8.402LeuLeu: 8.402 ± 0.134	1.916LeuMet: 1.916 ± 0.05	6.039LeuAsn: 6.039 ± 0.095	3.411LeuPro: 3.411 ± 0.073	3.362LeuGln: 3.362 ± 0.069	2.78LeuArg: 2.78 ± 0.066	6.328LeuSer: 6.328 ± 0.089	4.911LeuThr: 4.911 ± 0.076	5.676LeuVal: 5.676 ± 0.097	0.714LeuTrp: 0.714 ± 0.033	3.179LeuTyr: 3.179 ± 0.054	0.0LeuXaa: 0.0 ± 0.0
Met	1.471MetAla: 1.471 ± 0.052	0.143MetCys: 0.143 ± 0.011	0.981MetAsp: 0.981 ± 0.034	1.346MetGlu: 1.346 ± 0.044	0.953MetPhe: 0.953 ± 0.038	1.295MetGly: 1.295 ± 0.046	0.405MetHis: 0.405 ± 0.022	1.538MetIle: 1.538 ± 0.045	2.263MetLys: 2.263 ± 0.053	1.853MetLeu: 1.853 ± 0.045	0.564MetMet: 0.564 ± 0.029	1.421MetAsn: 1.421 ± 0.039	0.781MetPro: 0.781 ± 0.034	0.857MetGln: 0.857 ± 0.035	0.819MetArg: 0.819 ± 0.032	1.392MetSer: 1.392 ± 0.044	1.121MetThr: 1.121 ± 0.043	1.304MetVal: 1.304 ± 0.048	0.149MetTrp: 0.149 ± 0.014	0.777MetTyr: 0.777 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	3.755AsnAla: 3.755 ± 0.069	0.564AsnCys: 0.564 ± 0.028	3.453AsnAsp: 3.453 ± 0.066	4.634AsnGlu: 4.634 ± 0.07	3.793AsnPhe: 3.793 ± 0.079	4.428AsnGly: 4.428 ± 0.115	1.119AsnHis: 1.119 ± 0.04	5.116AsnIle: 5.116 ± 0.075	4.941AsnLys: 4.941 ± 0.091	5.832AsnLeu: 5.832 ± 0.08	1.306AsnMet: 1.306 ± 0.038	4.577AsnAsn: 4.577 ± 0.101	2.879AsnPro: 2.879 ± 0.065	2.654AsnGln: 2.654 ± 0.058	2.091AsnArg: 2.091 ± 0.052	4.398AsnSer: 4.398 ± 0.078	3.55AsnThr: 3.55 ± 0.078	3.922AsnVal: 3.922 ± 0.086	0.906AsnTrp: 0.906 ± 0.042	3.271AsnTyr: 3.271 ± 0.072	0.0AsnXaa: 0.0 ± 0.0
Pro	1.82ProAla: 1.82 ± 0.057	0.225ProCys: 0.225 ± 0.016	1.678ProAsp: 1.678 ± 0.044	2.591ProGlu: 2.591 ± 0.058	1.905ProPhe: 1.905 ± 0.054	1.697ProGly: 1.697 ± 0.053	0.496ProHis: 0.496 ± 0.025	2.698ProIle: 2.698 ± 0.063	2.592ProLys: 2.592 ± 0.062	2.646ProLeu: 2.646 ± 0.058	0.707ProMet: 0.707 ± 0.034	2.382ProAsn: 2.382 ± 0.054	0.677ProPro: 0.677 ± 0.031	1.093ProGln: 1.093 ± 0.038	0.827ProArg: 0.827 ± 0.037	2.128ProSer: 2.128 ± 0.063	2.101ProThr: 2.101 ± 0.069	2.183ProVal: 2.183 ± 0.057	0.289ProTrp: 0.289 ± 0.017	1.39ProTyr: 1.39 ± 0.037	0.0ProXaa: 0.0 ± 0.0
Gln	1.96GlnAla: 1.96 ± 0.056	0.182GlnCys: 0.182 ± 0.016	1.679GlnAsp: 1.679 ± 0.04	2.513GlnGlu: 2.513 ± 0.057	1.892GlnPhe: 1.892 ± 0.049	1.739GlnGly: 1.739 ± 0.049	0.588GlnHis: 0.588 ± 0.029	2.829GlnIle: 2.829 ± 0.06	3.208GlnLys: 3.208 ± 0.072	3.471GlnLeu: 3.471 ± 0.069	0.821GlnMet: 0.821 ± 0.032	2.655GlnAsn: 2.655 ± 0.063	1.104GlnPro: 1.104 ± 0.038	1.328GlnGln: 1.328 ± 0.045	1.055GlnArg: 1.055 ± 0.037	1.861GlnSer: 1.861 ± 0.051	1.898GlnThr: 1.898 ± 0.047	2.096GlnVal: 2.096 ± 0.056	0.332GlnTrp: 0.332 ± 0.023	1.546GlnTyr: 1.546 ± 0.048	0.0GlnXaa: 0.0 ± 0.0
Arg	1.773ArgAla: 1.773 ± 0.046	0.175ArgCys: 0.175 ± 0.015	1.519ArgAsp: 1.519 ± 0.046	2.137ArgGlu: 2.137 ± 0.055	1.74ArgPhe: 1.74 ± 0.047	1.683ArgGly: 1.683 ± 0.048	0.54ArgHis: 0.54 ± 0.023	2.703ArgIle: 2.703 ± 0.058	2.613ArgLys: 2.613 ± 0.06	2.844ArgLeu: 2.844 ± 0.064	0.823ArgMet: 0.823 ± 0.028	2.059ArgAsn: 2.059 ± 0.052	0.893ArgPro: 0.893 ± 0.036	0.916ArgGln: 0.916 ± 0.03	1.114ArgArg: 1.114 ± 0.043	1.589ArgSer: 1.589 ± 0.052	1.653ArgThr: 1.653 ± 0.042	1.955ArgVal: 1.955 ± 0.05	0.309ArgTrp: 0.309 ± 0.019	1.362ArgTyr: 1.362 ± 0.046	0.0ArgXaa: 0.0 ± 0.0
Ser	3.435SerAla: 3.435 ± 0.075	0.71SerCys: 0.71 ± 0.033	3.208SerAsp: 3.208 ± 0.077	4.009SerGlu: 4.009 ± 0.071	4.084SerPhe: 4.084 ± 0.077	4.371SerGly: 4.371 ± 0.097	0.999SerHis: 0.999 ± 0.038	5.337SerIle: 5.337 ± 0.088	5.16SerLys: 5.16 ± 0.101	5.797SerLeu: 5.797 ± 0.088	1.185SerMet: 1.185 ± 0.039	4.29SerAsn: 4.29 ± 0.097	1.923SerPro: 1.923 ± 0.051	2.235SerGln: 2.235 ± 0.053	1.797SerArg: 1.797 ± 0.044	4.362SerSer: 4.362 ± 0.125	3.501SerThr: 3.501 ± 0.075	4.097SerVal: 4.097 ± 0.081	0.642SerTrp: 0.642 ± 0.028	2.716SerTyr: 2.716 ± 0.063	0.0SerXaa: 0.0 ± 0.0
Thr	3.528ThrAla: 3.528 ± 0.083	0.398ThrCys: 0.398 ± 0.026	2.978ThrAsp: 2.978 ± 0.062	3.612ThrGlu: 3.612 ± 0.064	3.16ThrPhe: 3.16 ± 0.074	3.861ThrGly: 3.861 ± 0.096	0.991ThrHis: 0.991 ± 0.036	5.253ThrIle: 5.253 ± 0.098	4.138ThrLys: 4.138 ± 0.064	5.211ThrLeu: 5.211 ± 0.086	0.913ThrMet: 0.913 ± 0.033	3.798ThrAsn: 3.798 ± 0.092	2.333ThrPro: 2.333 ± 0.061	1.943ThrGln: 1.943 ± 0.046	1.481ThrArg: 1.481 ± 0.044	3.919ThrSer: 3.919 ± 0.093	3.829ThrThr: 3.829 ± 0.104	3.619ThrVal: 3.619 ± 0.084	0.505ThrTrp: 0.505 ± 0.03	2.294ThrTyr: 2.294 ± 0.066	0.0ThrXaa: 0.0 ± 0.0
Val	4.34ValAla: 4.34 ± 0.08	0.512ValCys: 0.512 ± 0.025	3.566ValAsp: 3.566 ± 0.07	4.205ValGlu: 4.205 ± 0.092	3.497ValPhe: 3.497 ± 0.071	3.808ValGly: 3.808 ± 0.075	0.962ValHis: 0.962 ± 0.036	5.034ValIle: 5.034 ± 0.087	4.705ValLys: 4.705 ± 0.08	6.069ValLeu: 6.069 ± 0.095	1.354ValMet: 1.354 ± 0.049	3.914ValAsn: 3.914 ± 0.07	2.168ValPro: 2.168 ± 0.051	1.916ValGln: 1.916 ± 0.051	1.878ValArg: 1.878 ± 0.046	4.332ValSer: 4.332 ± 0.073	3.897ValThr: 3.897 ± 0.09	4.543ValVal: 4.543 ± 0.092	0.529ValTrp: 0.529 ± 0.025	2.488ValTyr: 2.488 ± 0.059	0.0ValXaa: 0.0 ± 0.0
Trp	0.518TrpAla: 0.518 ± 0.028	0.072TrpCys: 0.072 ± 0.01	0.522TrpAsp: 0.522 ± 0.029	0.634TrpGlu: 0.634 ± 0.027	0.547TrpPhe: 0.547 ± 0.024	0.549TrpGly: 0.549 ± 0.03	0.206TrpHis: 0.206 ± 0.017	0.711TrpIle: 0.711 ± 0.032	0.849TrpLys: 0.849 ± 0.033	0.918TrpLeu: 0.918 ± 0.036	0.288TrpMet: 0.288 ± 0.017	0.794TrpAsn: 0.794 ± 0.036	0.176TrpPro: 0.176 ± 0.016	0.388TrpGln: 0.388 ± 0.021	0.296TrpArg: 0.296 ± 0.02	0.613TrpSer: 0.613 ± 0.034	0.528TrpThr: 0.528 ± 0.029	0.557TrpVal: 0.557 ± 0.025	0.12TrpTrp: 0.12 ± 0.011	0.415TrpTyr: 0.415 ± 0.022	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.241TyrAla: 2.241 ± 0.055	0.36TyrCys: 0.36 ± 0.021	2.394TyrAsp: 2.394 ± 0.059	2.482TyrGlu: 2.482 ± 0.057	2.749TyrPhe: 2.749 ± 0.065	2.545TyrGly: 2.545 ± 0.071	0.791TyrHis: 0.791 ± 0.031	2.874TyrIle: 2.874 ± 0.055	3.12TyrLys: 3.12 ± 0.068	4.041TyrLeu: 4.041 ± 0.076	0.739TyrMet: 0.739 ± 0.029	2.983TyrAsn: 2.983 ± 0.067	1.414TyrPro: 1.414 ± 0.041	1.631TyrGln: 1.631 ± 0.047	1.444TyrArg: 1.444 ± 0.038	2.72TyrSer: 2.72 ± 0.066	2.316TyrThr: 2.316 ± 0.055	2.284TyrVal: 2.284 ± 0.053	0.469TyrTrp: 0.469 ± 0.024	1.995TyrTyr: 1.995 ± 0.065	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2604 proteins (857636 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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