Amino acid dipepetide frequency for SAR202 cluster bacterium AD-802-F09_MRT_200m

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.272AlaAla: 9.272 ± 0.27
1.009AlaCys: 1.009 ± 0.057
5.113AlaAsp: 5.113 ± 0.125
5.668AlaGlu: 5.668 ± 0.136
3.454AlaPhe: 3.454 ± 0.117
8.051AlaGly: 8.051 ± 0.187
1.701AlaHis: 1.701 ± 0.079
5.552AlaIle: 5.552 ± 0.145
3.444AlaLys: 3.444 ± 0.113
8.824AlaLeu: 8.824 ± 0.223
2.816AlaMet: 2.816 ± 0.137
3.021AlaAsn: 3.021 ± 0.101
3.63AlaPro: 3.63 ± 0.115
2.944AlaGln: 2.944 ± 0.097
4.713AlaArg: 4.713 ± 0.129
5.517AlaSer: 5.517 ± 0.136
4.908AlaThr: 4.908 ± 0.167
7.539AlaVal: 7.539 ± 0.185
1.121AlaTrp: 1.121 ± 0.054
2.374AlaTyr: 2.374 ± 0.087
0.0AlaXaa: 0.0 ± 0.0
Cys
0.83CysAla: 0.83 ± 0.059
0.128CysCys: 0.128 ± 0.02
0.513CysAsp: 0.513 ± 0.036
0.535CysGlu: 0.535 ± 0.036
0.433CysPhe: 0.433 ± 0.037
0.939CysGly: 0.939 ± 0.061
0.25CysHis: 0.25 ± 0.029
0.487CysIle: 0.487 ± 0.037
0.269CysLys: 0.269 ± 0.035
0.91CysLeu: 0.91 ± 0.054
0.24CysMet: 0.24 ± 0.026
0.368CysAsn: 0.368 ± 0.038
0.545CysPro: 0.545 ± 0.045
0.381CysGln: 0.381 ± 0.04
0.65CysArg: 0.65 ± 0.044
0.676CysSer: 0.676 ± 0.043
0.445CysThr: 0.445 ± 0.034
0.599CysVal: 0.599 ± 0.04
0.17CysTrp: 0.17 ± 0.023
0.25CysTyr: 0.25 ± 0.027
0.0CysXaa: 0.0 ± 0.0
Asp
4.944AspAla: 4.944 ± 0.125
0.522AspCys: 0.522 ± 0.043
3.249AspAsp: 3.249 ± 0.121
3.633AspGlu: 3.633 ± 0.114
2.39AspPhe: 2.39 ± 0.098
5.014AspGly: 5.014 ± 0.134
1.31AspHis: 1.31 ± 0.062
3.56AspIle: 3.56 ± 0.111
1.813AspLys: 1.813 ± 0.073
5.914AspLeu: 5.914 ± 0.146
1.663AspMet: 1.663 ± 0.084
1.897AspAsn: 1.897 ± 0.089
3.46AspPro: 3.46 ± 0.105
2.252AspGln: 2.252 ± 0.093
3.726AspArg: 3.726 ± 0.117
3.771AspSer: 3.771 ± 0.105
3.005AspThr: 3.005 ± 0.101
4.296AspVal: 4.296 ± 0.117
1.022AspTrp: 1.022 ± 0.058
1.881AspTyr: 1.881 ± 0.079
0.0AspXaa: 0.0 ± 0.0
Glu
5.914GluAla: 5.914 ± 0.159
0.477GluCys: 0.477 ± 0.042
3.55GluAsp: 3.55 ± 0.115
4.582GluGlu: 4.582 ± 0.149
2.608GluPhe: 2.608 ± 0.087
4.61GluGly: 4.61 ± 0.133
1.467GluHis: 1.467 ± 0.068
3.944GluIle: 3.944 ± 0.106
2.345GluLys: 2.345 ± 0.089
5.959GluLeu: 5.959 ± 0.157
1.688GluMet: 1.688 ± 0.079
2.153GluAsn: 2.153 ± 0.091
2.685GluPro: 2.685 ± 0.085
2.445GluGln: 2.445 ± 0.08
3.886GluArg: 3.886 ± 0.13
4.04GluSer: 4.04 ± 0.126
3.3GluThr: 3.3 ± 0.103
4.799GluVal: 4.799 ± 0.131
0.904GluTrp: 0.904 ± 0.063
1.974GluTyr: 1.974 ± 0.079
0.0GluXaa: 0.0 ± 0.0
Phe
3.073PheAla: 3.073 ± 0.102
0.455PheCys: 0.455 ± 0.038
2.65PheAsp: 2.65 ± 0.101
2.175PheGlu: 2.175 ± 0.085
1.669PhePhe: 1.669 ± 0.078
3.784PheGly: 3.784 ± 0.125
0.859PheHis: 0.859 ± 0.058
2.191PheIle: 2.191 ± 0.074
1.381PheLys: 1.381 ± 0.064
3.733PheLeu: 3.733 ± 0.135
0.923PheMet: 0.923 ± 0.059
1.355PheAsn: 1.355 ± 0.065
1.836PhePro: 1.836 ± 0.084
1.496PheGln: 1.496 ± 0.063
2.07PheArg: 2.07 ± 0.087
2.701PheSer: 2.701 ± 0.104
2.259PheThr: 2.259 ± 0.076
2.579PheVal: 2.579 ± 0.096
0.596PheTrp: 0.596 ± 0.044
1.099PheTyr: 1.099 ± 0.054
0.0PheXaa: 0.0 ± 0.0
Gly
7.045GlyAla: 7.045 ± 0.183
0.852GlyCys: 0.852 ± 0.059
4.396GlyAsp: 4.396 ± 0.143
4.867GlyGlu: 4.867 ± 0.135
3.771GlyPhe: 3.771 ± 0.094
7.331GlyGly: 7.331 ± 0.201
2.067GlyHis: 2.067 ± 0.087
5.629GlyIle: 5.629 ± 0.123
3.393GlyLys: 3.393 ± 0.103
8.497GlyLeu: 8.497 ± 0.179
2.791GlyMet: 2.791 ± 0.126
2.855GlyAsn: 2.855 ± 0.1
3.777GlyPro: 3.777 ± 0.109
3.069GlyGln: 3.069 ± 0.101
5.258GlyArg: 5.258 ± 0.15
5.937GlySer: 5.937 ± 0.162
4.691GlyThr: 4.691 ± 0.12
6.767GlyVal: 6.767 ± 0.162
1.525GlyTrp: 1.525 ± 0.075
2.605GlyTyr: 2.605 ± 0.092
0.0GlyXaa: 0.0 ± 0.0
His
1.551HisAla: 1.551 ± 0.073
0.276HisCys: 0.276 ± 0.036
1.028HisAsp: 1.028 ± 0.052
1.16HisGlu: 1.16 ± 0.058
0.782HisPhe: 0.782 ± 0.058
1.916HisGly: 1.916 ± 0.076
0.673HisHis: 0.673 ± 0.053
1.182HisIle: 1.182 ± 0.06
0.519HisLys: 0.519 ± 0.036
2.207HisLeu: 2.207 ± 0.086
0.525HisMet: 0.525 ± 0.047
0.676HisAsn: 0.676 ± 0.042
1.503HisPro: 1.503 ± 0.07
0.769HisGln: 0.769 ± 0.043
1.285HisArg: 1.285 ± 0.071
1.349HisSer: 1.349 ± 0.071
1.131HisThr: 1.131 ± 0.056
1.503HisVal: 1.503 ± 0.074
0.391HisTrp: 0.391 ± 0.035
0.714HisTyr: 0.714 ± 0.05
0.0HisXaa: 0.0 ± 0.0
Ile
5.648IleAla: 5.648 ± 0.14
0.599IleCys: 0.599 ± 0.048
3.797IleAsp: 3.797 ± 0.13
3.511IleGlu: 3.511 ± 0.109
2.172IlePhe: 2.172 ± 0.106
5.373IleGly: 5.373 ± 0.151
1.096IleHis: 1.096 ± 0.05
3.197IleIle: 3.197 ± 0.107
1.999IleLys: 1.999 ± 0.077
4.95IleLeu: 4.95 ± 0.143
1.432IleMet: 1.432 ± 0.062
2.249IleAsn: 2.249 ± 0.081
3.197IlePro: 3.197 ± 0.092
1.833IleGln: 1.833 ± 0.09
3.066IleArg: 3.066 ± 0.101
4.348IleSer: 4.348 ± 0.115
3.486IleThr: 3.486 ± 0.113
4.127IleVal: 4.127 ± 0.122
0.798IleTrp: 0.798 ± 0.055
1.451IleTyr: 1.451 ± 0.077
0.0IleXaa: 0.0 ± 0.0
Lys
3.242LysAla: 3.242 ± 0.111
0.247LysCys: 0.247 ± 0.027
2.207LysAsp: 2.207 ± 0.103
2.582LysGlu: 2.582 ± 0.102
1.192LysPhe: 1.192 ± 0.063
2.595LysGly: 2.595 ± 0.094
0.686LysHis: 0.686 ± 0.051
2.108LysIle: 2.108 ± 0.068
1.147LysLys: 1.147 ± 0.064
3.066LysLeu: 3.066 ± 0.107
0.865LysMet: 0.865 ± 0.052
1.093LysAsn: 1.093 ± 0.056
1.743LysPro: 1.743 ± 0.083
1.032LysGln: 1.032 ± 0.061
1.775LysArg: 1.775 ± 0.077
2.031LysSer: 2.031 ± 0.084
2.031LysThr: 2.031 ± 0.076
2.807LysVal: 2.807 ± 0.103
0.426LysTrp: 0.426 ± 0.035
0.984LysTyr: 0.984 ± 0.062
0.0LysXaa: 0.0 ± 0.0
Leu
10.028LeuAla: 10.028 ± 0.225
0.884LeuCys: 0.884 ± 0.046
6.091LeuAsp: 6.091 ± 0.145
6.53LeuGlu: 6.53 ± 0.157
3.287LeuPhe: 3.287 ± 0.113
8.612LeuGly: 8.612 ± 0.192
1.72LeuHis: 1.72 ± 0.068
5.168LeuIle: 5.168 ± 0.145
3.358LeuLys: 3.358 ± 0.12
8.647LeuLeu: 8.647 ± 0.235
2.384LeuMet: 2.384 ± 0.106
3.165LeuAsn: 3.165 ± 0.1
4.851LeuPro: 4.851 ± 0.114
2.534LeuGln: 2.534 ± 0.094
5.197LeuArg: 5.197 ± 0.131
6.357LeuSer: 6.357 ± 0.192
5.245LeuThr: 5.245 ± 0.131
7.298LeuVal: 7.298 ± 0.178
1.266LeuTrp: 1.266 ± 0.071
2.169LeuTyr: 2.169 ± 0.098
0.0LeuXaa: 0.0 ± 0.0
Met
3.262MetAla: 3.262 ± 0.119
0.231MetCys: 0.231 ± 0.028
1.704MetAsp: 1.704 ± 0.094
1.618MetGlu: 1.618 ± 0.084
0.968MetPhe: 0.968 ± 0.092
2.682MetGly: 2.682 ± 0.132
0.506MetHis: 0.506 ± 0.044
1.407MetIle: 1.407 ± 0.077
0.936MetLys: 0.936 ± 0.06
2.387MetLeu: 2.387 ± 0.097
0.747MetMet: 0.747 ± 0.059
0.904MetAsn: 0.904 ± 0.053
1.4MetPro: 1.4 ± 0.072
0.714MetGln: 0.714 ± 0.048
1.605MetArg: 1.605 ± 0.079
1.586MetSer: 1.586 ± 0.078
1.733MetThr: 1.733 ± 0.082
2.332MetVal: 2.332 ± 0.083
0.292MetTrp: 0.292 ± 0.031
0.586MetTyr: 0.586 ± 0.044
0.0MetXaa: 0.0 ± 0.0
Asn
2.759AsnAla: 2.759 ± 0.087
0.333AsnCys: 0.333 ± 0.035
1.922AsnAsp: 1.922 ± 0.086
1.647AsnGlu: 1.647 ± 0.064
1.205AsnPhe: 1.205 ± 0.06
2.791AsnGly: 2.791 ± 0.089
0.734AsnHis: 0.734 ± 0.044
2.012AsnIle: 2.012 ± 0.066
0.942AsnLys: 0.942 ± 0.055
3.499AsnLeu: 3.499 ± 0.087
0.852AsnMet: 0.852 ± 0.058
1.16AsnAsn: 1.16 ± 0.057
2.461AsnPro: 2.461 ± 0.09
1.339AsnGln: 1.339 ± 0.068
2.057AsnArg: 2.057 ± 0.085
1.977AsnSer: 1.977 ± 0.072
1.698AsnThr: 1.698 ± 0.076
2.602AsnVal: 2.602 ± 0.08
0.548AsnTrp: 0.548 ± 0.043
1.067AsnTyr: 1.067 ± 0.068
0.0AsnXaa: 0.0 ± 0.0
Pro
4.139ProAla: 4.139 ± 0.131
0.359ProCys: 0.359 ± 0.032
3.646ProAsp: 3.646 ± 0.119
4.098ProGlu: 4.098 ± 0.132
1.855ProPhe: 1.855 ± 0.085
4.652ProGly: 4.652 ± 0.141
1.051ProHis: 1.051 ± 0.062
2.672ProIle: 2.672 ± 0.105
1.762ProLys: 1.762 ± 0.073
4.155ProLeu: 4.155 ± 0.121
1.304ProMet: 1.304 ± 0.067
1.829ProAsn: 1.829 ± 0.08
2.313ProPro: 2.313 ± 0.111
1.608ProGln: 1.608 ± 0.072
2.32ProArg: 2.32 ± 0.097
3.143ProSer: 3.143 ± 0.109
2.986ProThr: 2.986 ± 0.123
4.159ProVal: 4.159 ± 0.104
0.871ProTrp: 0.871 ± 0.053
1.483ProTyr: 1.483 ± 0.073
0.0ProXaa: 0.0 ± 0.0
Gln
3.531GlnAla: 3.531 ± 0.113
0.256GlnCys: 0.256 ± 0.029
1.868GlnAsp: 1.868 ± 0.081
2.284GlnGlu: 2.284 ± 0.092
1.064GlnPhe: 1.064 ± 0.055
2.714GlnGly: 2.714 ± 0.089
0.682GlnHis: 0.682 ± 0.05
2.012GlnIle: 2.012 ± 0.079
1.182GlnLys: 1.182 ± 0.065
2.989GlnLeu: 2.989 ± 0.093
0.987GlnMet: 0.987 ± 0.063
0.977GlnAsn: 0.977 ± 0.053
1.512GlnPro: 1.512 ± 0.065
1.362GlnGln: 1.362 ± 0.074
2.063GlnArg: 2.063 ± 0.077
2.159GlnSer: 2.159 ± 0.086
1.765GlnThr: 1.765 ± 0.078
2.909GlnVal: 2.909 ± 0.097
0.548GlnTrp: 0.548 ± 0.042
0.916GlnTyr: 0.916 ± 0.058
0.0GlnXaa: 0.0 ± 0.0
Arg
4.457ArgAla: 4.457 ± 0.131
0.557ArgCys: 0.557 ± 0.046
3.265ArgAsp: 3.265 ± 0.109
3.694ArgGlu: 3.694 ± 0.123
2.477ArgPhe: 2.477 ± 0.093
4.152ArgGly: 4.152 ± 0.12
1.189ArgHis: 1.189 ± 0.064
3.383ArgIle: 3.383 ± 0.107
1.727ArgLys: 1.727 ± 0.066
5.77ArgLeu: 5.77 ± 0.157
1.845ArgMet: 1.845 ± 0.074
1.922ArgAsn: 1.922 ± 0.076
2.941ArgPro: 2.941 ± 0.107
1.99ArgGln: 1.99 ± 0.075
3.604ArgArg: 3.604 ± 0.131
3.585ArgSer: 3.585 ± 0.101
2.906ArgThr: 2.906 ± 0.095
4.155ArgVal: 4.155 ± 0.134
0.98ArgTrp: 0.98 ± 0.058
1.868ArgTyr: 1.868 ± 0.085
0.0ArgXaa: 0.0 ± 0.0
Ser
5.318SerAla: 5.318 ± 0.139
0.65SerCys: 0.65 ± 0.049
3.957SerAsp: 3.957 ± 0.113
3.95SerGlu: 3.95 ± 0.106
2.499SerPhe: 2.499 ± 0.09
6.494SerGly: 6.494 ± 0.155
1.567SerHis: 1.567 ± 0.067
3.72SerIle: 3.72 ± 0.123
2.076SerLys: 2.076 ± 0.083
6.059SerLeu: 6.059 ± 0.163
1.749SerMet: 1.749 ± 0.094
2.111SerAsn: 2.111 ± 0.091
3.489SerPro: 3.489 ± 0.116
2.201SerGln: 2.201 ± 0.076
3.707SerArg: 3.707 ± 0.113
4.501SerSer: 4.501 ± 0.153
3.521SerThr: 3.521 ± 0.113
4.976SerVal: 4.976 ± 0.137
1.032SerTrp: 1.032 ± 0.061
1.845SerTyr: 1.845 ± 0.07
0.0SerXaa: 0.0 ± 0.0
Thr
4.95ThrAla: 4.95 ± 0.128
0.474ThrCys: 0.474 ± 0.042
2.967ThrAsp: 2.967 ± 0.084
3.335ThrGlu: 3.335 ± 0.111
2.05ThrPhe: 2.05 ± 0.074
5.165ThrGly: 5.165 ± 0.131
1.099ThrHis: 1.099 ± 0.059
3.156ThrIle: 3.156 ± 0.095
1.961ThrLys: 1.961 ± 0.085
5.245ThrLeu: 5.245 ± 0.135
1.541ThrMet: 1.541 ± 0.084
1.775ThrAsn: 1.775 ± 0.07
3.233ThrPro: 3.233 ± 0.132
1.688ThrGln: 1.688 ± 0.078
2.717ThrArg: 2.717 ± 0.09
3.646ThrSer: 3.646 ± 0.109
3.079ThrThr: 3.079 ± 0.104
4.524ThrVal: 4.524 ± 0.121
0.766ThrTrp: 0.766 ± 0.053
1.496ThrTyr: 1.496 ± 0.07
0.0ThrXaa: 0.0 ± 0.0
Val
7.276ValAla: 7.276 ± 0.154
0.811ValCys: 0.811 ± 0.056
4.7ValAsp: 4.7 ± 0.134
4.876ValGlu: 4.876 ± 0.144
3.181ValPhe: 3.181 ± 0.109
6.655ValGly: 6.655 ± 0.158
1.41ValHis: 1.41 ± 0.064
4.812ValIle: 4.812 ± 0.121
2.406ValLys: 2.406 ± 0.093
7.555ValLeu: 7.555 ± 0.17
2.127ValMet: 2.127 ± 0.077
2.602ValAsn: 2.602 ± 0.099
3.694ValPro: 3.694 ± 0.108
2.294ValGln: 2.294 ± 0.08
4.139ValArg: 4.139 ± 0.131
5.232ValSer: 5.232 ± 0.13
4.361ValThr: 4.361 ± 0.128
6.539ValVal: 6.539 ± 0.163
1.009ValTrp: 1.009 ± 0.053
2.034ValTyr: 2.034 ± 0.074
0.0ValXaa: 0.0 ± 0.0
Trp
1.269TrpAla: 1.269 ± 0.065
0.176TrpCys: 0.176 ± 0.024
0.958TrpAsp: 0.958 ± 0.055
0.977TrpGlu: 0.977 ± 0.056
0.606TrpPhe: 0.606 ± 0.042
1.144TrpGly: 1.144 ± 0.061
0.397TrpHis: 0.397 ± 0.033
0.791TrpIle: 0.791 ± 0.046
0.481TrpLys: 0.481 ± 0.041
1.48TrpLeu: 1.48 ± 0.07
0.417TrpMet: 0.417 ± 0.034
0.554TrpAsn: 0.554 ± 0.039
0.634TrpPro: 0.634 ± 0.043
0.583TrpGln: 0.583 ± 0.044
0.823TrpArg: 0.823 ± 0.054
0.987TrpSer: 0.987 ± 0.058
0.823TrpThr: 0.823 ± 0.048
1.246TrpVal: 1.246 ± 0.066
0.218TrpTrp: 0.218 ± 0.023
0.388TrpTyr: 0.388 ± 0.032
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.166TyrAla: 2.166 ± 0.087
0.32TyrCys: 0.32 ± 0.034
1.743TyrAsp: 1.743 ± 0.084
1.608TyrGlu: 1.608 ± 0.066
1.221TyrPhe: 1.221 ± 0.056
2.448TyrGly: 2.448 ± 0.087
0.676TyrHis: 0.676 ± 0.055
1.346TyrIle: 1.346 ± 0.063
0.718TyrLys: 0.718 ± 0.046
2.944TyrLeu: 2.944 ± 0.102
0.698TyrMet: 0.698 ± 0.04
0.936TyrAsn: 0.936 ± 0.059
1.503TyrPro: 1.503 ± 0.066
1.246TyrGln: 1.246 ± 0.061
1.807TyrArg: 1.807 ± 0.074
1.884TyrSer: 1.884 ± 0.077
1.493TyrThr: 1.493 ± 0.06
1.958TyrVal: 1.958 ± 0.08
0.471TyrTrp: 0.471 ± 0.038
0.929TyrTyr: 0.929 ± 0.066
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1047 proteins (312120 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski