Amino acid dipepetide frequency for Vitis riparia x Vitis cinerea

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.742AlaAla: 4.742 ± 0.628
0.862AlaCys: 0.862 ± 0.181
1.724AlaAsp: 1.724 ± 0.233
2.586AlaGlu: 2.586 ± 0.339
3.233AlaPhe: 3.233 ± 0.355
4.445AlaGly: 4.445 ± 0.418
1.805AlaHis: 1.805 ± 0.343
4.607AlaIle: 4.607 ± 0.427
2.209AlaLys: 2.209 ± 0.273
5.954AlaLeu: 5.954 ± 0.522
1.428AlaMet: 1.428 ± 0.226
1.967AlaAsn: 1.967 ± 0.221
3.233AlaPro: 3.233 ± 0.356
2.29AlaGln: 2.29 ± 0.314
3.852AlaArg: 3.852 ± 0.358
4.068AlaSer: 4.068 ± 0.345
3.206AlaThr: 3.206 ± 0.399
3.799AlaVal: 3.799 ± 0.359
0.862AlaTrp: 0.862 ± 0.216
1.967AlaTyr: 1.967 ± 0.242
0.0AlaXaa: 0.0 ± 0.0
Cys
0.539CysAla: 0.539 ± 0.129
0.189CysCys: 0.189 ± 0.07
0.485CysAsp: 0.485 ± 0.112
0.808CysGlu: 0.808 ± 0.167
0.862CysPhe: 0.862 ± 0.16
0.889CysGly: 0.889 ± 0.182
0.323CysHis: 0.323 ± 0.113
1.347CysIle: 1.347 ± 0.171
0.485CysLys: 0.485 ± 0.111
1.401CysLeu: 1.401 ± 0.174
0.242CysMet: 0.242 ± 0.079
0.593CysAsn: 0.593 ± 0.154
0.647CysPro: 0.647 ± 0.154
0.242CysGln: 0.242 ± 0.059
0.647CysArg: 0.647 ± 0.157
0.97CysSer: 0.97 ± 0.194
0.404CysThr: 0.404 ± 0.104
0.754CysVal: 0.754 ± 0.138
0.162CysTrp: 0.162 ± 0.063
0.727CysTyr: 0.727 ± 0.16
0.0CysXaa: 0.0 ± 0.0
Asp
1.859AspAla: 1.859 ± 0.249
0.296AspCys: 0.296 ± 0.106
1.67AspAsp: 1.67 ± 0.282
1.643AspGlu: 1.643 ± 0.222
1.616AspPhe: 1.616 ± 0.23
2.344AspGly: 2.344 ± 0.297
0.889AspHis: 0.889 ± 0.168
3.448AspIle: 3.448 ± 0.307
1.67AspLys: 1.67 ± 0.247
4.58AspLeu: 4.58 ± 0.407
0.862AspMet: 0.862 ± 0.137
1.589AspAsn: 1.589 ± 0.208
2.856AspPro: 2.856 ± 0.351
1.832AspGln: 1.832 ± 0.241
3.098AspArg: 3.098 ± 0.388
2.532AspSer: 2.532 ± 0.44
2.021AspThr: 2.021 ± 0.235
1.94AspVal: 1.94 ± 0.247
0.62AspTrp: 0.62 ± 0.113
1.212AspTyr: 1.212 ± 0.207
0.0AspXaa: 0.0 ± 0.0
Glu
3.341GluAla: 3.341 ± 0.394
0.485GluCys: 0.485 ± 0.128
1.616GluAsp: 1.616 ± 0.247
3.206GluGlu: 3.206 ± 0.401
2.128GluPhe: 2.128 ± 0.226
3.314GluGly: 3.314 ± 0.301
0.97GluHis: 0.97 ± 0.14
4.58GluIle: 4.58 ± 0.404
3.394GluLys: 3.394 ± 0.42
5.173GluLeu: 5.173 ± 0.42
1.805GluMet: 1.805 ± 0.197
1.859GluAsn: 1.859 ± 0.218
1.563GluPro: 1.563 ± 0.201
2.128GluGln: 2.128 ± 0.216
3.394GluArg: 3.394 ± 0.366
3.475GluSer: 3.475 ± 0.365
2.856GluThr: 2.856 ± 0.405
2.505GluVal: 2.505 ± 0.286
0.647GluTrp: 0.647 ± 0.131
1.563GluTyr: 1.563 ± 0.216
0.0GluXaa: 0.0 ± 0.0
Phe
2.856PheAla: 2.856 ± 0.322
1.078PheCys: 1.078 ± 0.194
2.29PheAsp: 2.29 ± 0.285
2.209PheGlu: 2.209 ± 0.298
4.418PhePhe: 4.418 ± 0.466
3.718PheGly: 3.718 ± 0.41
1.967PheHis: 1.967 ± 0.258
4.364PheIle: 4.364 ± 0.417
1.158PheLys: 1.158 ± 0.198
8.163PheLeu: 8.163 ± 0.664
1.374PheMet: 1.374 ± 0.194
1.589PheAsn: 1.589 ± 0.23
2.829PhePro: 2.829 ± 0.3
1.94PheGln: 1.94 ± 0.216
3.071PheArg: 3.071 ± 0.234
3.987PheSer: 3.987 ± 0.439
2.505PheThr: 2.505 ± 0.239
3.341PheVal: 3.341 ± 0.419
0.781PheTrp: 0.781 ± 0.167
2.29PheTyr: 2.29 ± 0.263
0.0PheXaa: 0.0 ± 0.0
Gly
4.418GlyAla: 4.418 ± 0.464
0.566GlyCys: 0.566 ± 0.148
2.371GlyAsp: 2.371 ± 0.288
2.802GlyGlu: 2.802 ± 0.352
3.772GlyPhe: 3.772 ± 0.347
4.607GlyGly: 4.607 ± 0.526
1.805GlyHis: 1.805 ± 0.285
6.627GlyIle: 6.627 ± 0.541
3.368GlyLys: 3.368 ± 0.337
6.6GlyLeu: 6.6 ± 0.58
1.778GlyMet: 1.778 ± 0.267
2.613GlyAsn: 2.613 ± 0.232
2.479GlyPro: 2.479 ± 0.248
2.64GlyGln: 2.64 ± 0.295
4.903GlyArg: 4.903 ± 0.539
6.008GlySer: 6.008 ± 0.476
3.772GlyThr: 3.772 ± 0.32
4.607GlyVal: 4.607 ± 0.427
1.266GlyTrp: 1.266 ± 0.214
2.155GlyTyr: 2.155 ± 0.288
0.0GlyXaa: 0.0 ± 0.0
His
1.293HisAla: 1.293 ± 0.237
0.135HisCys: 0.135 ± 0.059
0.754HisAsp: 0.754 ± 0.184
0.862HisGlu: 0.862 ± 0.176
2.371HisPhe: 2.371 ± 0.284
1.751HisGly: 1.751 ± 0.213
0.862HisHis: 0.862 ± 0.244
1.832HisIle: 1.832 ± 0.31
1.131HisLys: 1.131 ± 0.182
2.802HisLeu: 2.802 ± 0.335
0.674HisMet: 0.674 ± 0.114
1.105HisAsn: 1.105 ± 0.219
1.131HisPro: 1.131 ± 0.196
0.808HisGln: 0.808 ± 0.127
1.401HisArg: 1.401 ± 0.23
1.724HisSer: 1.724 ± 0.285
1.105HisThr: 1.105 ± 0.167
1.212HisVal: 1.212 ± 0.188
0.296HisTrp: 0.296 ± 0.076
1.105HisTyr: 1.105 ± 0.211
0.0HisXaa: 0.0 ± 0.0
Ile
5.092IleAla: 5.092 ± 0.49
1.589IleCys: 1.589 ± 0.215
3.233IleAsp: 3.233 ± 0.408
3.745IleGlu: 3.745 ± 0.373
4.768IlePhe: 4.768 ± 0.428
5.9IleGly: 5.9 ± 0.474
2.559IleHis: 2.559 ± 0.276
5.415IleIle: 5.415 ± 0.372
3.341IleLys: 3.341 ± 0.444
8.163IleLeu: 8.163 ± 0.498
1.158IleMet: 1.158 ± 0.183
3.206IleAsn: 3.206 ± 0.364
5.226IlePro: 5.226 ± 0.411
2.775IleGln: 2.775 ± 0.268
5.334IleArg: 5.334 ± 0.419
7.489IleSer: 7.489 ± 0.477
4.984IleThr: 4.984 ± 0.414
4.391IleVal: 4.391 ± 0.343
1.347IleTrp: 1.347 ± 0.186
3.421IleTyr: 3.421 ± 0.306
0.0IleXaa: 0.0 ± 0.0
Lys
2.209LysAla: 2.209 ± 0.315
0.62LysCys: 0.62 ± 0.13
2.532LysAsp: 2.532 ± 0.405
3.368LysGlu: 3.368 ± 0.442
1.536LysPhe: 1.536 ± 0.262
2.829LysGly: 2.829 ± 0.266
1.051LysHis: 1.051 ± 0.168
3.799LysIle: 3.799 ± 0.41
5.146LysLys: 5.146 ± 0.704
3.664LysLeu: 3.664 ± 0.388
1.239LysMet: 1.239 ± 0.251
2.91LysAsn: 2.91 ± 0.41
2.021LysPro: 2.021 ± 0.232
1.697LysGln: 1.697 ± 0.242
4.122LysArg: 4.122 ± 0.444
3.394LysSer: 3.394 ± 0.337
2.021LysThr: 2.021 ± 0.267
2.101LysVal: 2.101 ± 0.249
0.754LysTrp: 0.754 ± 0.217
2.236LysTyr: 2.236 ± 0.317
0.0LysXaa: 0.0 ± 0.0
Leu
6.951LeuAla: 6.951 ± 0.57
1.347LeuCys: 1.347 ± 0.229
3.502LeuAsp: 3.502 ± 0.343
4.984LeuGlu: 4.984 ± 0.396
7.22LeuPhe: 7.22 ± 0.654
7.57LeuGly: 7.57 ± 0.561
2.371LeuHis: 2.371 ± 0.243
7.84LeuIle: 7.84 ± 0.517
3.691LeuLys: 3.691 ± 0.357
11.935LeuLeu: 11.935 ± 0.739
2.586LeuMet: 2.586 ± 0.255
4.472LeuAsn: 4.472 ± 0.351
4.93LeuPro: 4.93 ± 0.402
2.532LeuGln: 2.532 ± 0.263
5.981LeuArg: 5.981 ± 0.455
7.84LeuSer: 7.84 ± 0.558
5.307LeuThr: 5.307 ± 0.34
6.681LeuVal: 6.681 ± 0.471
1.401LeuTrp: 1.401 ± 0.196
3.772LeuTyr: 3.772 ± 0.282
0.0LeuXaa: 0.0 ± 0.0
Met
1.428MetAla: 1.428 ± 0.181
0.216MetCys: 0.216 ± 0.083
0.862MetAsp: 0.862 ± 0.177
1.428MetGlu: 1.428 ± 0.204
1.266MetPhe: 1.266 ± 0.169
1.913MetGly: 1.913 ± 0.186
0.97MetHis: 0.97 ± 0.216
2.398MetIle: 2.398 ± 0.304
1.482MetLys: 1.482 ± 0.219
1.94MetLeu: 1.94 ± 0.267
0.62MetMet: 0.62 ± 0.145
1.374MetAsn: 1.374 ± 0.18
1.293MetPro: 1.293 ± 0.192
0.7MetGln: 0.7 ± 0.144
1.158MetArg: 1.158 ± 0.219
2.209MetSer: 2.209 ± 0.226
1.158MetThr: 1.158 ± 0.183
1.185MetVal: 1.185 ± 0.165
0.35MetTrp: 0.35 ± 0.117
0.7MetTyr: 0.7 ± 0.14
0.0MetXaa: 0.0 ± 0.0
Asn
1.913AsnAla: 1.913 ± 0.224
0.458AsnCys: 0.458 ± 0.102
1.751AsnAsp: 1.751 ± 0.283
2.425AsnGlu: 2.425 ± 0.286
1.94AsnPhe: 1.94 ± 0.259
2.452AsnGly: 2.452 ± 0.25
0.97AsnHis: 0.97 ± 0.185
2.883AsnIle: 2.883 ± 0.274
2.856AsnLys: 2.856 ± 0.422
4.176AsnLeu: 4.176 ± 0.366
1.051AsnMet: 1.051 ± 0.155
2.452AsnAsn: 2.452 ± 0.386
2.425AsnPro: 2.425 ± 0.286
2.209AsnGln: 2.209 ± 0.388
3.152AsnArg: 3.152 ± 0.257
3.368AsnSer: 3.368 ± 0.328
1.94AsnThr: 1.94 ± 0.226
2.505AsnVal: 2.505 ± 0.286
0.889AsnTrp: 0.889 ± 0.144
1.589AsnTyr: 1.589 ± 0.249
0.0AsnXaa: 0.0 ± 0.0
Pro
2.64ProAla: 2.64 ± 0.318
0.377ProCys: 0.377 ± 0.11
1.536ProAsp: 1.536 ± 0.223
2.613ProGlu: 2.613 ± 0.254
2.91ProPhe: 2.91 ± 0.277
3.368ProGly: 3.368 ± 0.358
1.105ProHis: 1.105 ± 0.156
5.146ProIle: 5.146 ± 0.329
2.021ProLys: 2.021 ± 0.238
4.499ProLeu: 4.499 ± 0.316
1.024ProMet: 1.024 ± 0.154
1.589ProAsn: 1.589 ± 0.246
2.29ProPro: 2.29 ± 0.364
1.482ProGln: 1.482 ± 0.184
2.748ProArg: 2.748 ± 0.288
3.502ProSer: 3.502 ± 0.291
2.721ProThr: 2.721 ± 0.286
3.341ProVal: 3.341 ± 0.34
0.943ProTrp: 0.943 ± 0.14
1.482ProTyr: 1.482 ± 0.217
0.0ProXaa: 0.0 ± 0.0
Gln
2.101GlnAla: 2.101 ± 0.286
0.323GlnCys: 0.323 ± 0.092
1.589GlnAsp: 1.589 ± 0.19
2.236GlnGlu: 2.236 ± 0.249
1.94GlnPhe: 1.94 ± 0.238
2.101GlnGly: 2.101 ± 0.261
0.485GlnHis: 0.485 ± 0.113
2.937GlnIle: 2.937 ± 0.248
2.344GlnLys: 2.344 ± 0.361
3.233GlnLeu: 3.233 ± 0.284
0.97GlnMet: 0.97 ± 0.161
1.266GlnAsn: 1.266 ± 0.189
1.401GlnPro: 1.401 ± 0.168
1.482GlnGln: 1.482 ± 0.18
2.209GlnArg: 2.209 ± 0.247
2.29GlnSer: 2.29 ± 0.238
1.778GlnThr: 1.778 ± 0.21
1.967GlnVal: 1.967 ± 0.296
0.512GlnTrp: 0.512 ± 0.14
1.239GlnTyr: 1.239 ± 0.191
0.0GlnXaa: 0.0 ± 0.0
Arg
3.691ArgAla: 3.691 ± 0.391
0.97ArgCys: 0.97 ± 0.133
2.963ArgAsp: 2.963 ± 0.303
3.448ArgGlu: 3.448 ± 0.38
2.505ArgPhe: 2.505 ± 0.378
4.607ArgGly: 4.607 ± 0.428
0.889ArgHis: 0.889 ± 0.189
6.223ArgIle: 6.223 ± 0.426
4.257ArgLys: 4.257 ± 0.399
5.199ArgLeu: 5.199 ± 0.445
1.67ArgMet: 1.67 ± 0.251
4.041ArgAsn: 4.041 ± 0.432
2.263ArgPro: 2.263 ± 0.28
2.398ArgGln: 2.398 ± 0.267
4.31ArgArg: 4.31 ± 0.442
5.334ArgSer: 5.334 ± 0.484
3.475ArgThr: 3.475 ± 0.353
3.206ArgVal: 3.206 ± 0.329
1.078ArgTrp: 1.078 ± 0.184
1.94ArgTyr: 1.94 ± 0.218
0.0ArgXaa: 0.0 ± 0.0
Ser
3.799SerAla: 3.799 ± 0.372
0.916SerCys: 0.916 ± 0.212
3.125SerAsp: 3.125 ± 0.41
3.502SerGlu: 3.502 ± 0.45
4.607SerPhe: 4.607 ± 0.43
5.092SerGly: 5.092 ± 0.408
1.374SerHis: 1.374 ± 0.2
7.139SerIle: 7.139 ± 0.539
3.745SerLys: 3.745 ± 0.404
8.486SerLeu: 8.486 ± 0.43
2.29SerMet: 2.29 ± 0.266
3.987SerAsn: 3.987 ± 0.482
3.61SerPro: 3.61 ± 0.376
2.425SerGln: 2.425 ± 0.266
4.634SerArg: 4.634 ± 0.432
7.085SerSer: 7.085 ± 0.558
4.58SerThr: 4.58 ± 0.351
4.688SerVal: 4.688 ± 0.382
1.482SerTrp: 1.482 ± 0.233
3.206SerTyr: 3.206 ± 0.4
0.0SerXaa: 0.0 ± 0.0
Thr
2.99ThrAla: 2.99 ± 0.302
0.889ThrCys: 0.889 ± 0.16
1.832ThrAsp: 1.832 ± 0.218
2.452ThrGlu: 2.452 ± 0.297
2.586ThrPhe: 2.586 ± 0.299
3.906ThrGly: 3.906 ± 0.35
1.239ThrHis: 1.239 ± 0.201
4.768ThrIle: 4.768 ± 0.408
2.532ThrLys: 2.532 ± 0.315
5.253ThrLeu: 5.253 ± 0.404
1.212ThrMet: 1.212 ± 0.208
2.559ThrAsn: 2.559 ± 0.21
2.128ThrPro: 2.128 ± 0.22
1.428ThrGln: 1.428 ± 0.169
3.421ThrArg: 3.421 ± 0.316
5.307ThrSer: 5.307 ± 0.376
2.856ThrThr: 2.856 ± 0.344
2.613ThrVal: 2.613 ± 0.322
0.566ThrTrp: 0.566 ± 0.123
1.563ThrTyr: 1.563 ± 0.193
0.0ThrXaa: 0.0 ± 0.0
Val
4.23ValAla: 4.23 ± 0.451
0.7ValCys: 0.7 ± 0.16
2.479ValAsp: 2.479 ± 0.274
2.856ValGlu: 2.856 ± 0.232
3.314ValPhe: 3.314 ± 0.311
4.284ValGly: 4.284 ± 0.458
1.482ValHis: 1.482 ± 0.266
3.583ValIle: 3.583 ± 0.301
2.236ValLys: 2.236 ± 0.223
5.738ValLeu: 5.738 ± 0.446
1.347ValMet: 1.347 ± 0.185
1.913ValAsn: 1.913 ± 0.183
3.233ValPro: 3.233 ± 0.341
1.455ValGln: 1.455 ± 0.208
3.879ValArg: 3.879 ± 0.374
4.849ValSer: 4.849 ± 0.346
2.99ValThr: 2.99 ± 0.336
3.529ValVal: 3.529 ± 0.307
1.185ValTrp: 1.185 ± 0.208
1.94ValTyr: 1.94 ± 0.208
0.0ValXaa: 0.0 ± 0.0
Trp
1.239TrpAla: 1.239 ± 0.242
0.189TrpCys: 0.189 ± 0.073
0.7TrpAsp: 0.7 ± 0.133
0.674TrpGlu: 0.674 ± 0.153
0.943TrpPhe: 0.943 ± 0.159
1.185TrpGly: 1.185 ± 0.189
0.485TrpHis: 0.485 ± 0.125
1.751TrpIle: 1.751 ± 0.172
0.781TrpLys: 0.781 ± 0.121
1.859TrpLeu: 1.859 ± 0.254
0.431TrpMet: 0.431 ± 0.104
0.647TrpAsn: 0.647 ± 0.125
0.35TrpPro: 0.35 ± 0.099
0.458TrpGln: 0.458 ± 0.116
0.674TrpArg: 0.674 ± 0.122
1.293TrpSer: 1.293 ± 0.184
0.647TrpThr: 0.647 ± 0.146
0.943TrpVal: 0.943 ± 0.156
0.431TrpTrp: 0.431 ± 0.112
0.512TrpTyr: 0.512 ± 0.118
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.509TyrAla: 1.509 ± 0.195
0.512TyrCys: 0.512 ± 0.102
1.563TyrAsp: 1.563 ± 0.244
2.155TyrGlu: 2.155 ± 0.227
2.021TyrPhe: 2.021 ± 0.186
2.883TyrGly: 2.883 ± 0.28
0.754TyrHis: 0.754 ± 0.155
2.452TyrIle: 2.452 ± 0.244
1.401TyrLys: 1.401 ± 0.253
4.095TyrLeu: 4.095 ± 0.445
0.862TyrMet: 0.862 ± 0.14
1.67TyrAsn: 1.67 ± 0.251
1.428TyrPro: 1.428 ± 0.183
1.482TyrGln: 1.482 ± 0.256
2.479TyrArg: 2.479 ± 0.261
3.044TyrSer: 3.044 ± 0.367
1.778TyrThr: 1.778 ± 0.214
1.913TyrVal: 1.913 ± 0.207
0.62TyrTrp: 0.62 ± 0.118
0.97TyrTyr: 0.97 ± 0.145
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 138 proteins (37120 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski