Amino acid dipepetide frequency for Streptomyces cyaneogriseus subsp. noncyanogenus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	22.871AlaAla: 22.871 ± 0.214	1.117AlaCys: 1.117 ± 0.027	8.473AlaAsp: 8.473 ± 0.078	9.242AlaGlu: 9.242 ± 0.107	3.537AlaPhe: 3.537 ± 0.046	14.073AlaGly: 14.073 ± 0.108	3.038AlaHis: 3.038 ± 0.041	3.21AlaIle: 3.21 ± 0.054	2.568AlaLys: 2.568 ± 0.05	14.794AlaLeu: 14.794 ± 0.123	2.412AlaMet: 2.412 ± 0.044	1.729AlaAsn: 1.729 ± 0.033	7.681AlaPro: 7.681 ± 0.102	3.7AlaGln: 3.7 ± 0.046	11.496AlaArg: 11.496 ± 0.111	5.596AlaSer: 5.596 ± 0.056	6.756AlaThr: 6.756 ± 0.061	12.68AlaVal: 12.68 ± 0.107	1.921AlaTrp: 1.921 ± 0.033	2.938AlaTyr: 2.938 ± 0.045	0.0AlaXaa: 0.0 ± 0.0
Cys	1.18CysAla: 1.18 ± 0.026	0.092CysCys: 0.092 ± 0.007	0.47CysAsp: 0.47 ± 0.017	0.412CysGlu: 0.412 ± 0.017	0.228CysPhe: 0.228 ± 0.011	0.975CysGly: 0.975 ± 0.024	0.195CysHis: 0.195 ± 0.011	0.155CysIle: 0.155 ± 0.008	0.105CysLys: 0.105 ± 0.008	0.793CysLeu: 0.793 ± 0.02	0.122CysMet: 0.122 ± 0.008	0.134CysAsn: 0.134 ± 0.008	0.481CysPro: 0.481 ± 0.017	0.151CysGln: 0.151 ± 0.009	0.595CysArg: 0.595 ± 0.019	0.407CysSer: 0.407 ± 0.017	0.481CysThr: 0.481 ± 0.016	0.698CysVal: 0.698 ± 0.018	0.13CysTrp: 0.13 ± 0.008	0.142CysTyr: 0.142 ± 0.009	0.0CysXaa: 0.0 ± 0.0
Asp	7.754AspAla: 7.754 ± 0.083	0.419AspCys: 0.419 ± 0.015	3.538AspAsp: 3.538 ± 0.046	3.808AspGlu: 3.808 ± 0.047	1.629AspPhe: 1.629 ± 0.031	6.689AspGly: 6.689 ± 0.075	1.414AspHis: 1.414 ± 0.026	1.841AspIle: 1.841 ± 0.033	1.148AspLys: 1.148 ± 0.032	6.138AspLeu: 6.138 ± 0.057	0.764AspMet: 0.764 ± 0.02	0.885AspAsn: 0.885 ± 0.024	4.689AspPro: 4.689 ± 0.061	1.38AspGln: 1.38 ± 0.026	5.076AspArg: 5.076 ± 0.053	2.266AspSer: 2.266 ± 0.034	3.246AspThr: 3.246 ± 0.048	4.645AspVal: 4.645 ± 0.046	1.015AspTrp: 1.015 ± 0.025	1.1AspTyr: 1.1 ± 0.026	0.0AspXaa: 0.0 ± 0.0
Glu	7.684GluAla: 7.684 ± 0.097	0.372GluCys: 0.372 ± 0.013	2.99GluAsp: 2.99 ± 0.044	3.976GluGlu: 3.976 ± 0.049	1.449GluPhe: 1.449 ± 0.031	4.539GluGly: 4.539 ± 0.055	1.532GluHis: 1.532 ± 0.029	2.318GluIle: 2.318 ± 0.038	1.518GluLys: 1.518 ± 0.033	6.903GluLeu: 6.903 ± 0.071	0.91GluMet: 0.91 ± 0.021	1.009GluAsn: 1.009 ± 0.022	3.504GluPro: 3.504 ± 0.048	2.173GluGln: 2.173 ± 0.04	5.985GluArg: 5.985 ± 0.067	2.392GluSer: 2.392 ± 0.037	3.004GluThr: 3.004 ± 0.041	4.598GluVal: 4.598 ± 0.061	0.779GluTrp: 0.779 ± 0.021	1.175GluTyr: 1.175 ± 0.024	0.0GluXaa: 0.0 ± 0.0
Phe	3.673PheAla: 3.673 ± 0.048	0.26PheCys: 0.26 ± 0.013	1.902PheAsp: 1.902 ± 0.033	1.423PheGlu: 1.423 ± 0.03	0.842PhePhe: 0.842 ± 0.025	2.968PheGly: 2.968 ± 0.045	0.624PheHis: 0.624 ± 0.017	0.639PheIle: 0.639 ± 0.018	0.483PheLys: 0.483 ± 0.018	2.597PheLeu: 2.597 ± 0.041	0.387PheMet: 0.387 ± 0.013	0.536PheAsn: 0.536 ± 0.02	1.375PhePro: 1.375 ± 0.027	0.668PheGln: 0.668 ± 0.018	1.93PheArg: 1.93 ± 0.031	1.379PheSer: 1.379 ± 0.028	1.998PheThr: 1.998 ± 0.035	2.17PheVal: 2.17 ± 0.038	0.415PheTrp: 0.415 ± 0.017	0.562PheTyr: 0.562 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	11.629GlyAla: 11.629 ± 0.108	0.827GlyCys: 0.827 ± 0.022	5.386GlyAsp: 5.386 ± 0.063	5.504GlyGlu: 5.504 ± 0.062	2.88GlyPhe: 2.88 ± 0.042	9.241GlyGly: 9.241 ± 0.097	2.358GlyHis: 2.358 ± 0.034	3.305GlyIle: 3.305 ± 0.042	2.368GlyLys: 2.368 ± 0.043	9.465GlyLeu: 9.465 ± 0.087	1.989GlyMet: 1.989 ± 0.029	1.663GlyAsn: 1.663 ± 0.036	5.49GlyPro: 5.49 ± 0.071	2.596GlyGln: 2.596 ± 0.045	8.42GlyArg: 8.42 ± 0.077	5.085GlySer: 5.085 ± 0.058	6.664GlyThr: 6.664 ± 0.067	7.625GlyVal: 7.625 ± 0.073	1.724GlyTrp: 1.724 ± 0.034	2.304GlyTyr: 2.304 ± 0.036	0.0GlyXaa: 0.0 ± 0.0
His	2.738HisAla: 2.738 ± 0.04	0.217HisCys: 0.217 ± 0.011	1.331HisAsp: 1.331 ± 0.027	1.215HisGlu: 1.215 ± 0.026	0.637HisPhe: 0.637 ± 0.017	2.462HisGly: 2.462 ± 0.038	0.68HisHis: 0.68 ± 0.02	0.675HisIle: 0.675 ± 0.018	0.343HisLys: 0.343 ± 0.013	2.504HisLeu: 2.504 ± 0.038	0.322HisMet: 0.322 ± 0.013	0.345HisAsn: 0.345 ± 0.014	1.903HisPro: 1.903 ± 0.036	0.614HisGln: 0.614 ± 0.018	2.207HisArg: 2.207 ± 0.038	0.959HisSer: 0.959 ± 0.024	1.371HisThr: 1.371 ± 0.029	1.703HisVal: 1.703 ± 0.032	0.367HisTrp: 0.367 ± 0.015	0.459HisTyr: 0.459 ± 0.015	0.0HisXaa: 0.0 ± 0.0
Ile	4.598IleAla: 4.598 ± 0.062	0.283IleCys: 0.283 ± 0.013	2.134IleAsp: 2.134 ± 0.037	1.942IleGlu: 1.942 ± 0.033	0.637IlePhe: 0.637 ± 0.021	3.436IleGly: 3.436 ± 0.055	0.601IleHis: 0.601 ± 0.02	0.798IleIle: 0.798 ± 0.023	0.678IleLys: 0.678 ± 0.022	2.281IleLeu: 2.281 ± 0.032	0.42IleMet: 0.42 ± 0.015	0.609IleAsn: 0.609 ± 0.02	1.664IlePro: 1.664 ± 0.029	0.65IleGln: 0.65 ± 0.019	2.212IleArg: 2.212 ± 0.034	1.435IleSer: 1.435 ± 0.03	2.115IleThr: 2.115 ± 0.036	2.675IleVal: 2.675 ± 0.046	0.336IleTrp: 0.336 ± 0.012	0.481IleTyr: 0.481 ± 0.017	0.0IleXaa: 0.0 ± 0.0
Lys	2.825LysAla: 2.825 ± 0.057	0.109LysCys: 0.109 ± 0.008	1.295LysAsp: 1.295 ± 0.031	1.207LysGlu: 1.207 ± 0.031	0.43LysPhe: 0.43 ± 0.017	1.751LysGly: 1.751 ± 0.032	0.394LysHis: 0.394 ± 0.016	0.835LysIle: 0.835 ± 0.024	0.818LysLys: 0.818 ± 0.032	1.921LysLeu: 1.921 ± 0.037	0.386LysMet: 0.386 ± 0.016	0.501LysAsn: 0.501 ± 0.019	1.264LysPro: 1.264 ± 0.032	0.617LysGln: 0.617 ± 0.019	1.438LysArg: 1.438 ± 0.031	0.997LysSer: 0.997 ± 0.025	1.248LysThr: 1.248 ± 0.033	1.831LysVal: 1.831 ± 0.036	0.233LysTrp: 0.233 ± 0.01	0.429LysTyr: 0.429 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	15.506LeuAla: 15.506 ± 0.127	0.854LeuCys: 0.854 ± 0.023	6.734LeuAsp: 6.734 ± 0.062	4.971LeuGlu: 4.971 ± 0.053	2.595LeuPhe: 2.595 ± 0.045	9.169LeuGly: 9.169 ± 0.081	2.24LeuHis: 2.24 ± 0.037	2.995LeuIle: 2.995 ± 0.046	2.045LeuLys: 2.045 ± 0.039	11.23LeuLeu: 11.23 ± 0.117	1.573LeuMet: 1.573 ± 0.033	1.533LeuAsn: 1.533 ± 0.027	6.599LeuPro: 6.599 ± 0.066	2.079LeuGln: 2.079 ± 0.038	8.934LeuArg: 8.934 ± 0.082	5.021LeuSer: 5.021 ± 0.058	6.8LeuThr: 6.8 ± 0.069	8.685LeuVal: 8.685 ± 0.083	1.311LeuTrp: 1.311 ± 0.033	1.906LeuTyr: 1.906 ± 0.032	0.0LeuXaa: 0.0 ± 0.0
Met	2.257MetAla: 2.257 ± 0.037	0.141MetCys: 0.141 ± 0.008	0.885MetAsp: 0.885 ± 0.019	0.754MetGlu: 0.754 ± 0.02	0.44MetPhe: 0.44 ± 0.015	1.279MetGly: 1.279 ± 0.027	0.327MetHis: 0.327 ± 0.012	0.622MetIle: 0.622 ± 0.019	0.419MetLys: 0.419 ± 0.016	1.584MetLeu: 1.584 ± 0.03	0.283MetMet: 0.283 ± 0.014	0.412MetAsn: 0.412 ± 0.017	1.101MetPro: 1.101 ± 0.021	0.418MetGln: 0.418 ± 0.014	1.404MetArg: 1.404 ± 0.026	1.255MetSer: 1.255 ± 0.025	1.491MetThr: 1.491 ± 0.029	1.231MetVal: 1.231 ± 0.027	0.216MetTrp: 0.216 ± 0.011	0.336MetTyr: 0.336 ± 0.013	0.0MetXaa: 0.0 ± 0.0
Asn	2.065AsnAla: 2.065 ± 0.038	0.163AsnCys: 0.163 ± 0.008	0.887AsnAsp: 0.887 ± 0.025	0.775AsnGlu: 0.775 ± 0.021	0.468AsnPhe: 0.468 ± 0.017	1.749AsnGly: 1.749 ± 0.037	0.379AsnHis: 0.379 ± 0.014	0.606AsnIle: 0.606 ± 0.017	0.379AsnLys: 0.379 ± 0.014	1.557AsnLeu: 1.557 ± 0.034	0.293AsnMet: 0.293 ± 0.013	0.41AsnAsn: 0.41 ± 0.018	1.229AsnPro: 1.229 ± 0.029	0.449AsnGln: 0.449 ± 0.017	1.214AsnArg: 1.214 ± 0.029	0.775AsnSer: 0.775 ± 0.021	1.035AsnThr: 1.035 ± 0.032	1.32AsnVal: 1.32 ± 0.029	0.267AsnTrp: 0.267 ± 0.013	0.375AsnTyr: 0.375 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	9.599ProAla: 9.599 ± 0.114	0.354ProCys: 0.354 ± 0.013	4.453ProAsp: 4.453 ± 0.053	4.512ProGlu: 4.512 ± 0.049	1.471ProPhe: 1.471 ± 0.028	7.274ProGly: 7.274 ± 0.081	1.449ProHis: 1.449 ± 0.026	1.19ProIle: 1.19 ± 0.03	1.073ProLys: 1.073 ± 0.022	5.441ProLeu: 5.441 ± 0.058	0.978ProMet: 0.978 ± 0.024	0.815ProAsn: 0.815 ± 0.021	3.786ProPro: 3.786 ± 0.076	1.655ProGln: 1.655 ± 0.035	4.353ProArg: 4.353 ± 0.051	3.008ProSer: 3.008 ± 0.042	2.83ProThr: 2.83 ± 0.036	5.674ProVal: 5.674 ± 0.055	0.914ProTrp: 0.914 ± 0.021	1.447ProTyr: 1.447 ± 0.033	0.0ProXaa: 0.0 ± 0.0
Gln	3.736GlnAla: 3.736 ± 0.049	0.159GlnCys: 0.159 ± 0.009	1.362GlnAsp: 1.362 ± 0.028	1.489GlnGlu: 1.489 ± 0.032	0.597GlnPhe: 0.597 ± 0.018	2.285GlnGly: 2.285 ± 0.038	0.611GlnHis: 0.611 ± 0.018	1.02GlnIle: 1.02 ± 0.021	0.595GlnLys: 0.595 ± 0.018	2.642GlnLeu: 2.642 ± 0.047	0.47GlnMet: 0.47 ± 0.017	0.465GlnAsn: 0.465 ± 0.018	1.597GlnPro: 1.597 ± 0.035	1.109GlnGln: 1.109 ± 0.028	2.337GlnArg: 2.337 ± 0.037	1.108GlnSer: 1.108 ± 0.024	1.284GlnThr: 1.284 ± 0.025	2.297GlnVal: 2.297 ± 0.039	0.462GlnTrp: 0.462 ± 0.017	0.587GlnTyr: 0.587 ± 0.019	0.0GlnXaa: 0.0 ± 0.0
Arg	10.955ArgAla: 10.955 ± 0.101	0.617ArgCys: 0.617 ± 0.017	4.408ArgAsp: 4.408 ± 0.049	5.219ArgGlu: 5.219 ± 0.054	2.378ArgPhe: 2.378 ± 0.034	6.175ArgGly: 6.175 ± 0.072	2.284ArgHis: 2.284 ± 0.041	3.21ArgIle: 3.21 ± 0.04	1.619ArgLys: 1.619 ± 0.037	9.324ArgLeu: 9.324 ± 0.093	1.75ArgMet: 1.75 ± 0.026	1.339ArgAsn: 1.339 ± 0.03	5.42ArgPro: 5.42 ± 0.069	2.39ArgGln: 2.39 ± 0.035	8.418ArgArg: 8.418 ± 0.089	3.835ArgSer: 3.835 ± 0.05	5.58ArgThr: 5.58 ± 0.057	6.276ArgVal: 6.276 ± 0.083	1.426ArgTrp: 1.426 ± 0.031	1.892ArgTyr: 1.892 ± 0.033	0.0ArgXaa: 0.0 ± 0.0
Ser	6.374SerAla: 6.374 ± 0.066	0.371SerCys: 0.371 ± 0.014	2.357SerAsp: 2.357 ± 0.042	2.169SerGlu: 2.169 ± 0.039	1.459SerPhe: 1.459 ± 0.03	5.672SerGly: 5.672 ± 0.055	0.964SerHis: 0.964 ± 0.023	1.24SerIle: 1.24 ± 0.026	0.893SerLys: 0.893 ± 0.024	4.626SerLeu: 4.626 ± 0.06	0.971SerMet: 0.971 ± 0.02	0.748SerAsn: 0.748 ± 0.022	3.052SerPro: 3.052 ± 0.043	1.102SerGln: 1.102 ± 0.025	3.511SerArg: 3.511 ± 0.044	2.506SerSer: 2.506 ± 0.046	2.667SerThr: 2.667 ± 0.039	4.053SerVal: 4.053 ± 0.05	0.822SerTrp: 0.822 ± 0.021	1.171SerTyr: 1.171 ± 0.024	0.0SerXaa: 0.0 ± 0.0
Thr	9.068ThrAla: 9.068 ± 0.086	0.435ThrCys: 0.435 ± 0.017	3.499ThrAsp: 3.499 ± 0.039	3.255ThrGlu: 3.255 ± 0.045	1.566ThrPhe: 1.566 ± 0.033	7.06ThrGly: 7.06 ± 0.081	1.173ThrHis: 1.173 ± 0.024	1.559ThrIle: 1.559 ± 0.033	1.044ThrLys: 1.044 ± 0.026	5.61ThrLeu: 5.61 ± 0.061	0.873ThrMet: 0.873 ± 0.022	0.897ThrAsn: 0.897 ± 0.026	4.112ThrPro: 4.112 ± 0.053	1.253ThrGln: 1.253 ± 0.03	4.02ThrArg: 4.02 ± 0.05	2.845ThrSer: 2.845 ± 0.044	3.613ThrThr: 3.613 ± 0.052	6.026ThrVal: 6.026 ± 0.062	0.9ThrTrp: 0.9 ± 0.025	1.343ThrTyr: 1.343 ± 0.029	0.0ThrXaa: 0.0 ± 0.0
Val	10.738ValAla: 10.738 ± 0.102	0.813ValCys: 0.813 ± 0.019	4.907ValAsp: 4.907 ± 0.052	4.835ValGlu: 4.835 ± 0.064	2.455ValPhe: 2.455 ± 0.036	6.275ValGly: 6.275 ± 0.063	2.005ValHis: 2.005 ± 0.034	2.731ValIle: 2.731 ± 0.041	1.7ValLys: 1.7 ± 0.038	9.572ValLeu: 9.572 ± 0.086	1.419ValMet: 1.419 ± 0.028	1.552ValAsn: 1.552 ± 0.03	5.513ValPro: 5.513 ± 0.068	2.001ValGln: 2.001 ± 0.036	7.703ValArg: 7.703 ± 0.071	4.07ValSer: 4.07 ± 0.05	5.739ValThr: 5.739 ± 0.063	8.079ValVal: 8.079 ± 0.078	1.163ValTrp: 1.163 ± 0.025	1.655ValTyr: 1.655 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.705TrpAla: 1.705 ± 0.031	0.151TrpCys: 0.151 ± 0.009	0.848TrpAsp: 0.848 ± 0.026	0.79TrpGlu: 0.79 ± 0.021	0.496TrpPhe: 0.496 ± 0.018	1.062TrpGly: 1.062 ± 0.026	0.383TrpHis: 0.383 ± 0.014	0.547TrpIle: 0.547 ± 0.019	0.343TrpLys: 0.343 ± 0.015	1.736TrpLeu: 1.736 ± 0.033	0.289TrpMet: 0.289 ± 0.012	0.419TrpAsn: 0.419 ± 0.017	0.78TrpPro: 0.78 ± 0.022	0.602TrpGln: 0.602 ± 0.02	1.39TrpArg: 1.39 ± 0.032	0.899TrpSer: 0.899 ± 0.022	1.015TrpThr: 1.015 ± 0.024	0.947TrpVal: 0.947 ± 0.025	0.339TrpTrp: 0.339 ± 0.012	0.349TrpTyr: 0.349 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.875TyrAla: 2.875 ± 0.042	0.194TyrCys: 0.194 ± 0.01	1.586TyrAsp: 1.586 ± 0.034	1.313TyrGlu: 1.313 ± 0.027	0.638TyrPhe: 0.638 ± 0.02	2.391TyrGly: 2.391 ± 0.039	0.402TyrHis: 0.402 ± 0.015	0.487TyrIle: 0.487 ± 0.016	0.389TyrLys: 0.389 ± 0.015	2.062TyrLeu: 2.062 ± 0.029	0.242TyrMet: 0.242 ± 0.011	0.392TyrAsn: 0.392 ± 0.015	1.036TyrPro: 1.036 ± 0.028	0.607TyrGln: 0.607 ± 0.019	1.873TyrArg: 1.873 ± 0.037	0.89TyrSer: 0.89 ± 0.021	1.212TyrThr: 1.212 ± 0.023	1.71TyrVal: 1.71 ± 0.033	0.351TyrTrp: 0.351 ± 0.013	0.471TyrTyr: 0.471 ± 0.017	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5829 proteins (1944252 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---