Amino acid dipepetide frequency for Duck coronavirus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.455AlaAla: 5.455 ± 0.703
2.151AlaCys: 2.151 ± 0.408
3.304AlaAsp: 3.304 ± 0.686
2.382AlaGlu: 2.382 ± 0.393
2.843AlaPhe: 2.843 ± 0.939
4.994AlaGly: 4.994 ± 0.837
1.46AlaHis: 1.46 ± 0.406
3.918AlaIle: 3.918 ± 0.755
4.84AlaLys: 4.84 ± 0.737
6.223AlaLeu: 6.223 ± 0.566
1.921AlaMet: 1.921 ± 0.625
3.841AlaAsn: 3.841 ± 0.969
2.919AlaPro: 2.919 ± 0.707
2.612AlaGln: 2.612 ± 0.427
2.535AlaArg: 2.535 ± 1.206
3.765AlaSer: 3.765 ± 0.624
3.765AlaThr: 3.765 ± 0.295
5.839AlaVal: 5.839 ± 0.902
1.152AlaTrp: 1.152 ± 0.351
2.612AlaTyr: 2.612 ± 0.586
0.0AlaXaa: 0.0 ± 0.0
Cys
1.69CysAla: 1.69 ± 0.33
1.46CysCys: 1.46 ± 0.774
1.921CysAsp: 1.921 ± 0.286
1.229CysGlu: 1.229 ± 0.196
1.767CysPhe: 1.767 ± 0.405
2.689CysGly: 2.689 ± 0.486
0.691CysHis: 0.691 ± 0.126
1.613CysIle: 1.613 ± 0.268
2.305CysLys: 2.305 ± 0.543
2.305CysLeu: 2.305 ± 0.407
0.461CysMet: 0.461 ± 0.096
1.46CysAsn: 1.46 ± 0.461
0.922CysPro: 0.922 ± 0.254
0.615CysGln: 0.615 ± 0.127
1.306CysArg: 1.306 ± 0.438
1.537CysSer: 1.537 ± 0.462
1.152CysThr: 1.152 ± 0.656
2.689CysVal: 2.689 ± 0.334
0.538CysTrp: 0.538 ± 0.103
2.919CysTyr: 2.919 ± 0.568
0.0CysXaa: 0.0 ± 0.0
Asp
4.456AspAla: 4.456 ± 1.048
1.306AspCys: 1.306 ± 0.375
3.457AspAsp: 3.457 ± 0.965
2.689AspGlu: 2.689 ± 0.577
3.457AspPhe: 3.457 ± 0.661
3.688AspGly: 3.688 ± 0.725
0.154AspHis: 0.154 ± 0.088
2.382AspIle: 2.382 ± 0.498
2.612AspLys: 2.612 ± 0.622
4.84AspLeu: 4.84 ± 0.542
0.461AspMet: 0.461 ± 0.168
3.918AspAsn: 3.918 ± 0.771
1.921AspPro: 1.921 ± 0.539
2.074AspGln: 2.074 ± 0.538
2.074AspArg: 2.074 ± 0.278
4.61AspSer: 4.61 ± 0.591
2.766AspThr: 2.766 ± 0.499
5.224AspVal: 5.224 ± 0.757
0.615AspTrp: 0.615 ± 0.167
2.382AspTyr: 2.382 ± 0.722
0.0AspXaa: 0.0 ± 0.0
Glu
2.228GluAla: 2.228 ± 0.406
1.229GluCys: 1.229 ± 0.489
3.15GluAsp: 3.15 ± 0.429
4.687GluGlu: 4.687 ± 1.009
2.074GluPhe: 2.074 ± 0.425
2.074GluGly: 2.074 ± 0.84
1.076GluHis: 1.076 ± 0.173
1.383GluIle: 1.383 ± 0.5
2.766GluLys: 2.766 ± 0.407
3.765GluLeu: 3.765 ± 0.552
0.538GluMet: 0.538 ± 0.403
1.844GluAsn: 1.844 ± 0.507
1.844GluPro: 1.844 ± 0.389
2.074GluGln: 2.074 ± 0.341
2.074GluArg: 2.074 ± 0.59
3.15GluSer: 3.15 ± 0.7
4.226GluThr: 4.226 ± 0.885
3.995GluVal: 3.995 ± 0.697
0.077GluTrp: 0.077 ± 0.044
1.767GluTyr: 1.767 ± 0.134
0.0GluXaa: 0.0 ± 0.0
Phe
3.457PheAla: 3.457 ± 0.462
2.689PheCys: 2.689 ± 0.376
4.072PheAsp: 4.072 ± 0.534
2.689PheGlu: 2.689 ± 0.649
2.305PhePhe: 2.305 ± 0.377
2.535PheGly: 2.535 ± 0.467
0.154PheHis: 0.154 ± 0.088
2.996PheIle: 2.996 ± 0.511
3.765PheLys: 3.765 ± 0.997
4.763PheLeu: 4.763 ± 0.948
0.922PheMet: 0.922 ± 0.212
2.919PheAsn: 2.919 ± 1.187
0.845PhePro: 0.845 ± 0.288
1.613PheGln: 1.613 ± 0.755
0.999PheArg: 0.999 ± 0.367
4.379PheSer: 4.379 ± 0.277
3.918PheThr: 3.918 ± 0.58
7.299PheVal: 7.299 ± 1.307
1.613PheTrp: 1.613 ± 0.765
2.919PheTyr: 2.919 ± 0.281
0.0PheXaa: 0.0 ± 0.0
Gly
4.149GlyAla: 4.149 ± 0.843
1.46GlyCys: 1.46 ± 0.487
3.841GlyAsp: 3.841 ± 0.622
2.919GlyGlu: 2.919 ± 0.379
4.687GlyPhe: 4.687 ± 0.71
4.302GlyGly: 4.302 ± 1.072
1.613GlyHis: 1.613 ± 0.435
2.919GlyIle: 2.919 ± 0.453
3.688GlyLys: 3.688 ± 0.77
4.302GlyLeu: 4.302 ± 0.823
1.46GlyMet: 1.46 ± 0.287
3.38GlyAsn: 3.38 ± 0.721
1.306GlyPro: 1.306 ± 0.758
1.076GlyGln: 1.076 ± 0.844
2.305GlyArg: 2.305 ± 1.559
5.071GlySer: 5.071 ± 1.352
3.227GlyThr: 3.227 ± 0.542
7.606GlyVal: 7.606 ± 1.009
0.461GlyTrp: 0.461 ± 0.263
2.074GlyTyr: 2.074 ± 0.349
0.0GlyXaa: 0.0 ± 0.0
His
1.998HisAla: 1.998 ± 0.619
0.922HisCys: 0.922 ± 0.344
1.076HisAsp: 1.076 ± 0.183
1.076HisGlu: 1.076 ± 0.401
1.076HisPhe: 1.076 ± 0.332
0.768HisGly: 0.768 ± 0.144
0.307HisHis: 0.307 ± 0.126
1.306HisIle: 1.306 ± 0.403
0.999HisLys: 0.999 ± 0.3
1.69HisLeu: 1.69 ± 0.32
0.23HisMet: 0.23 ± 0.228
1.383HisAsn: 1.383 ± 0.504
0.691HisPro: 0.691 ± 0.252
0.461HisGln: 0.461 ± 0.269
0.154HisArg: 0.154 ± 0.063
0.845HisSer: 0.845 ± 0.397
1.46HisThr: 1.46 ± 0.261
1.537HisVal: 1.537 ± 0.212
0.154HisTrp: 0.154 ± 0.063
0.615HisTyr: 0.615 ± 0.406
0.0HisXaa: 0.0 ± 0.0
Ile
3.073IleAla: 3.073 ± 0.448
0.538IleCys: 0.538 ± 0.206
2.382IleAsp: 2.382 ± 0.322
1.69IleGlu: 1.69 ± 1.005
2.766IlePhe: 2.766 ± 0.733
2.228IleGly: 2.228 ± 0.422
0.538IleHis: 0.538 ± 0.244
1.844IleIle: 1.844 ± 1.09
1.46IleLys: 1.46 ± 0.411
4.379IleLeu: 4.379 ± 0.794
1.152IleMet: 1.152 ± 0.186
2.689IleAsn: 2.689 ± 1.115
2.689IlePro: 2.689 ± 0.922
1.921IleGln: 1.921 ± 0.392
2.305IleArg: 2.305 ± 0.15
2.996IleSer: 2.996 ± 0.955
2.612IleThr: 2.612 ± 0.233
3.688IleVal: 3.688 ± 0.543
0.384IleTrp: 0.384 ± 0.142
2.305IleTyr: 2.305 ± 0.931
0.0IleXaa: 0.0 ± 0.0
Lys
4.84LysAla: 4.84 ± 1.01
2.919LysCys: 2.919 ± 0.324
2.996LysAsp: 2.996 ± 0.457
3.995LysGlu: 3.995 ± 1.126
4.149LysPhe: 4.149 ± 0.805
3.765LysGly: 3.765 ± 0.435
1.076LysHis: 1.076 ± 0.442
1.844LysIle: 1.844 ± 0.392
2.843LysLys: 2.843 ± 0.382
6.223LysLeu: 6.223 ± 1.061
1.076LysMet: 1.076 ± 0.414
2.305LysAsn: 2.305 ± 0.458
4.456LysPro: 4.456 ± 0.671
1.69LysGln: 1.69 ± 0.48
2.612LysArg: 2.612 ± 0.618
3.841LysSer: 3.841 ± 0.728
2.612LysThr: 2.612 ± 0.56
6.915LysVal: 6.915 ± 1.212
0.999LysTrp: 0.999 ± 0.276
2.074LysTyr: 2.074 ± 0.767
0.0LysXaa: 0.0 ± 0.0
Leu
6.991LeuAla: 6.991 ± 0.879
2.074LeuCys: 2.074 ± 0.368
3.765LeuAsp: 3.765 ± 0.537
2.689LeuGlu: 2.689 ± 0.439
5.839LeuPhe: 5.839 ± 1.079
4.994LeuGly: 4.994 ± 0.402
1.998LeuHis: 1.998 ± 0.463
3.918LeuIle: 3.918 ± 0.909
6.838LeuLys: 6.838 ± 1.606
8.297LeuLeu: 8.297 ± 1.296
1.613LeuMet: 1.613 ± 0.4
4.226LeuAsn: 4.226 ± 1.894
3.304LeuPro: 3.304 ± 0.639
3.765LeuGln: 3.765 ± 1.22
2.919LeuArg: 2.919 ± 0.391
6.838LeuSer: 6.838 ± 1.215
4.072LeuThr: 4.072 ± 1.05
8.144LeuVal: 8.144 ± 1.017
1.383LeuTrp: 1.383 ± 0.533
5.301LeuTyr: 5.301 ± 0.925
0.0LeuXaa: 0.0 ± 0.0
Met
1.69MetAla: 1.69 ± 0.403
0.461MetCys: 0.461 ± 0.206
1.229MetAsp: 1.229 ± 0.33
0.154MetGlu: 0.154 ± 0.088
1.537MetPhe: 1.537 ± 0.299
0.999MetGly: 0.999 ± 0.299
0.768MetHis: 0.768 ± 0.284
0.23MetIle: 0.23 ± 0.297
0.538MetLys: 0.538 ± 0.201
2.228MetLeu: 2.228 ± 0.319
0.307MetMet: 0.307 ± 0.118
0.384MetAsn: 0.384 ± 0.251
0.691MetPro: 0.691 ± 0.159
0.384MetGln: 0.384 ± 0.116
0.999MetArg: 0.999 ± 0.224
1.152MetSer: 1.152 ± 0.182
0.999MetThr: 0.999 ± 0.426
1.921MetVal: 1.921 ± 0.319
0.154MetTrp: 0.154 ± 0.063
1.844MetTyr: 1.844 ± 0.383
0.0MetXaa: 0.0 ± 0.0
Asn
3.688AsnAla: 3.688 ± 0.643
1.69AsnCys: 1.69 ± 0.544
1.69AsnAsp: 1.69 ± 0.245
1.998AsnGlu: 1.998 ± 0.571
2.305AsnPhe: 2.305 ± 0.493
4.994AsnGly: 4.994 ± 1.216
0.768AsnHis: 0.768 ± 0.284
2.689AsnIle: 2.689 ± 0.444
3.227AsnLys: 3.227 ± 0.601
5.378AsnLeu: 5.378 ± 0.865
0.845AsnMet: 0.845 ± 0.351
2.689AsnAsn: 2.689 ± 0.697
1.921AsnPro: 1.921 ± 0.363
1.46AsnGln: 1.46 ± 0.355
1.152AsnArg: 1.152 ± 0.407
3.38AsnSer: 3.38 ± 1.204
2.074AsnThr: 2.074 ± 0.633
5.378AsnVal: 5.378 ± 0.769
0.768AsnTrp: 0.768 ± 0.284
2.919AsnTyr: 2.919 ± 0.907
0.0AsnXaa: 0.0 ± 0.0
Pro
1.383ProAla: 1.383 ± 0.6
0.461ProCys: 0.461 ± 0.269
2.305ProAsp: 2.305 ± 1.026
2.074ProGlu: 2.074 ± 0.447
1.69ProPhe: 1.69 ± 0.671
2.843ProGly: 2.843 ± 0.55
0.922ProHis: 0.922 ± 0.165
1.69ProIle: 1.69 ± 0.387
4.072ProLys: 4.072 ± 1.19
2.382ProLeu: 2.382 ± 0.287
0.384ProMet: 0.384 ± 0.196
2.459ProAsn: 2.459 ± 0.454
1.613ProPro: 1.613 ± 0.6
2.919ProGln: 2.919 ± 0.522
1.767ProArg: 1.767 ± 0.363
2.305ProSer: 2.305 ± 0.185
2.612ProThr: 2.612 ± 0.635
3.918ProVal: 3.918 ± 0.558
0.845ProTrp: 0.845 ± 0.17
1.998ProTyr: 1.998 ± 0.439
0.0ProXaa: 0.0 ± 0.0
Gln
2.151GlnAla: 2.151 ± 0.688
1.076GlnCys: 1.076 ± 0.479
1.306GlnAsp: 1.306 ± 0.356
1.613GlnGlu: 1.613 ± 0.482
1.229GlnPhe: 1.229 ± 0.361
1.844GlnGly: 1.844 ± 0.469
0.691GlnHis: 0.691 ± 0.555
1.306GlnIle: 1.306 ± 1.219
4.456GlnLys: 4.456 ± 1.081
2.612GlnLeu: 2.612 ± 1.03
0.307GlnMet: 0.307 ± 0.316
0.845GlnAsn: 0.845 ± 0.236
1.767GlnPro: 1.767 ± 0.446
1.46GlnGln: 1.46 ± 0.606
0.691GlnArg: 0.691 ± 0.229
2.689GlnSer: 2.689 ± 0.439
2.074GlnThr: 2.074 ± 0.39
3.073GlnVal: 3.073 ± 0.506
0.999GlnTrp: 0.999 ± 0.325
1.306GlnTyr: 1.306 ± 0.199
0.0GlnXaa: 0.0 ± 0.0
Arg
3.611ArgAla: 3.611 ± 0.338
0.768ArgCys: 0.768 ± 0.271
2.305ArgAsp: 2.305 ± 0.705
1.306ArgGlu: 1.306 ± 0.712
1.921ArgPhe: 1.921 ± 0.25
2.074ArgGly: 2.074 ± 0.701
1.537ArgHis: 1.537 ± 0.259
1.613ArgIle: 1.613 ± 0.35
1.69ArgLys: 1.69 ± 0.271
2.459ArgLeu: 2.459 ± 0.29
0.307ArgMet: 0.307 ± 0.258
2.843ArgAsn: 2.843 ± 0.552
0.768ArgPro: 0.768 ± 0.87
1.306ArgGln: 1.306 ± 1.131
1.46ArgArg: 1.46 ± 0.541
2.074ArgSer: 2.074 ± 0.937
1.306ArgThr: 1.306 ± 0.599
2.689ArgVal: 2.689 ± 0.395
0.23ArgTrp: 0.23 ± 0.189
1.69ArgTyr: 1.69 ± 0.338
0.0ArgXaa: 0.0 ± 0.0
Ser
4.149SerAla: 4.149 ± 0.341
1.613SerCys: 1.613 ± 0.585
4.456SerAsp: 4.456 ± 0.527
2.382SerGlu: 2.382 ± 0.31
5.608SerPhe: 5.608 ± 1.24
4.149SerGly: 4.149 ± 0.864
1.152SerHis: 1.152 ± 0.516
3.073SerIle: 3.073 ± 0.781
4.687SerLys: 4.687 ± 0.54
6.069SerLeu: 6.069 ± 2.044
1.076SerMet: 1.076 ± 0.213
3.227SerAsn: 3.227 ± 0.249
2.228SerPro: 2.228 ± 0.497
1.844SerGln: 1.844 ± 1.064
1.921SerArg: 1.921 ± 1.456
5.532SerSer: 5.532 ± 2.625
4.302SerThr: 4.302 ± 0.624
7.068SerVal: 7.068 ± 0.869
1.229SerTrp: 1.229 ± 0.238
3.457SerTyr: 3.457 ± 0.87
0.0SerXaa: 0.0 ± 0.0
Thr
4.149ThrAla: 4.149 ± 0.793
1.921ThrCys: 1.921 ± 0.463
1.921ThrAsp: 1.921 ± 0.594
1.537ThrGlu: 1.537 ± 0.896
3.073ThrPhe: 3.073 ± 0.836
3.304ThrGly: 3.304 ± 1.603
0.615ThrHis: 0.615 ± 0.127
2.228ThrIle: 2.228 ± 0.853
2.228ThrLys: 2.228 ± 0.572
5.301ThrLeu: 5.301 ± 0.703
1.844ThrMet: 1.844 ± 0.672
2.382ThrAsn: 2.382 ± 0.408
4.687ThrPro: 4.687 ± 1.027
2.689ThrGln: 2.689 ± 0.381
1.998ThrArg: 1.998 ± 0.464
3.995ThrSer: 3.995 ± 0.461
3.227ThrThr: 3.227 ± 1.143
6.991ThrVal: 6.991 ± 0.549
0.768ThrTrp: 0.768 ± 0.241
1.46ThrTyr: 1.46 ± 0.986
0.0ThrXaa: 0.0 ± 0.0
Val
5.916ValAla: 5.916 ± 0.663
3.38ValCys: 3.38 ± 0.544
6.069ValAsp: 6.069 ± 0.719
6.3ValGlu: 6.3 ± 1.322
5.762ValPhe: 5.762 ± 0.659
5.685ValGly: 5.685 ± 0.329
1.844ValHis: 1.844 ± 0.425
3.995ValIle: 3.995 ± 0.477
6.146ValLys: 6.146 ± 1.639
10.526ValLeu: 10.526 ± 1.387
1.921ValMet: 1.921 ± 0.436
4.687ValAsn: 4.687 ± 0.613
4.149ValPro: 4.149 ± 0.637
2.612ValGln: 2.612 ± 0.372
2.305ValArg: 2.305 ± 0.851
7.068ValSer: 7.068 ± 1.313
4.994ValThr: 4.994 ± 1.006
11.678ValVal: 11.678 ± 1.928
1.229ValTrp: 1.229 ± 0.266
4.149ValTyr: 4.149 ± 0.5
0.0ValXaa: 0.0 ± 0.0
Trp
0.845TrpAla: 0.845 ± 0.311
0.461TrpCys: 0.461 ± 0.194
0.538TrpAsp: 0.538 ± 0.287
0.768TrpGlu: 0.768 ± 0.284
1.152TrpPhe: 1.152 ± 0.351
0.922TrpGly: 0.922 ± 0.33
0.154TrpHis: 0.154 ± 0.162
0.615TrpIle: 0.615 ± 0.187
0.615TrpLys: 0.615 ± 0.303
1.767TrpLeu: 1.767 ± 0.402
0.461TrpMet: 0.461 ± 0.189
0.999TrpAsn: 0.999 ± 0.206
0.384TrpPro: 0.384 ± 0.412
0.154TrpGln: 0.154 ± 0.352
0.461TrpArg: 0.461 ± 0.184
0.845TrpSer: 0.845 ± 0.241
0.461TrpThr: 0.461 ± 0.168
1.306TrpVal: 1.306 ± 0.356
0.384TrpTrp: 0.384 ± 0.142
1.152TrpTyr: 1.152 ± 0.233
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.612TyrAla: 2.612 ± 0.448
2.689TyrCys: 2.689 ± 0.684
3.304TyrAsp: 3.304 ± 0.739
1.844TyrGlu: 1.844 ± 0.275
1.613TyrPhe: 1.613 ± 0.281
2.996TyrGly: 2.996 ± 1.296
1.229TyrHis: 1.229 ± 0.451
2.074TyrIle: 2.074 ± 0.826
3.457TyrLys: 3.457 ± 0.25
3.457TyrLeu: 3.457 ± 0.502
1.306TyrMet: 1.306 ± 0.516
2.535TyrAsn: 2.535 ± 0.543
1.537TyrPro: 1.537 ± 0.34
0.845TyrGln: 0.845 ± 0.247
1.921TyrArg: 1.921 ± 0.489
3.15TyrSer: 3.15 ± 0.741
4.456TyrThr: 4.456 ± 1.398
3.457TyrVal: 3.457 ± 0.547
0.461TyrTrp: 0.461 ± 0.245
2.689TyrTyr: 2.689 ± 0.825
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 12 proteins (13017 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski