Amino acid dipepetide frequency for Dorcoceras hygrometricum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	7.591AlaAla: 7.591 ± 0.036	1.233AlaCys: 1.233 ± 0.012	4.232AlaAsp: 4.232 ± 0.026	4.555AlaGlu: 4.555 ± 0.027	2.199AlaPhe: 2.199 ± 0.014	4.548AlaGly: 4.548 ± 0.023	1.538AlaHis: 1.538 ± 0.011	3.832AlaIle: 3.832 ± 0.017	4.118AlaLys: 4.118 ± 0.029	6.488AlaLeu: 6.488 ± 0.028	1.839AlaMet: 1.839 ± 0.012	2.368AlaAsn: 2.368 ± 0.014	3.453AlaPro: 3.453 ± 0.02	3.219AlaGln: 3.219 ± 0.021	4.68AlaArg: 4.68 ± 0.025	6.365AlaSer: 6.365 ± 0.029	4.393AlaThr: 4.393 ± 0.02	5.25AlaVal: 5.25 ± 0.023	0.75AlaTrp: 0.75 ± 0.008	1.51AlaTyr: 1.51 ± 0.014	0.001AlaXaa: 0.001 ± 0.0
Cys	1.343CysAla: 1.343 ± 0.012	0.544CysCys: 0.544 ± 0.007	0.987CysAsp: 0.987 ± 0.015	0.85CysGlu: 0.85 ± 0.007	0.769CysPhe: 0.769 ± 0.008	1.207CysGly: 1.207 ± 0.01	0.44CysHis: 0.44 ± 0.006	0.893CysIle: 0.893 ± 0.01	0.93CysLys: 0.93 ± 0.009	1.571CysLeu: 1.571 ± 0.012	0.495CysMet: 0.495 ± 0.006	0.663CysAsn: 0.663 ± 0.007	0.872CysPro: 0.872 ± 0.008	0.528CysGln: 0.528 ± 0.006	1.162CysArg: 1.162 ± 0.01	1.706CysSer: 1.706 ± 0.013	0.991CysThr: 0.991 ± 0.008	1.096CysVal: 1.096 ± 0.009	0.392CysTrp: 0.392 ± 0.006	0.488CysTyr: 0.488 ± 0.006	0.0CysXaa: 0.0 ± 0.0
Asp	3.762AspAla: 3.762 ± 0.018	0.763AspCys: 0.763 ± 0.009	3.776AspAsp: 3.776 ± 0.019	4.205AspGlu: 4.205 ± 0.021	2.405AspPhe: 2.405 ± 0.014	3.298AspGly: 3.298 ± 0.019	1.211AspHis: 1.211 ± 0.009	3.534AspIle: 3.534 ± 0.019	2.618AspLys: 2.618 ± 0.016	5.451AspLeu: 5.451 ± 0.02	1.265AspMet: 1.265 ± 0.01	1.715AspAsn: 1.715 ± 0.012	2.58AspPro: 2.58 ± 0.015	2.043AspGln: 2.043 ± 0.013	2.736AspArg: 2.736 ± 0.016	4.576AspSer: 4.576 ± 0.02	2.33AspThr: 2.33 ± 0.013	4.244AspVal: 4.244 ± 0.02	0.723AspTrp: 0.723 ± 0.013	1.288AspTyr: 1.288 ± 0.01	0.0AspXaa: 0.0 ± 0.0
Glu	4.889GluAla: 4.889 ± 0.024	0.73GluCys: 0.73 ± 0.007	3.685GluAsp: 3.685 ± 0.019	6.322GluGlu: 6.322 ± 0.034	2.589GluPhe: 2.589 ± 0.021	3.469GluGly: 3.469 ± 0.021	1.308GluHis: 1.308 ± 0.012	3.757GluIle: 3.757 ± 0.019	4.188GluLys: 4.188 ± 0.022	5.587GluLeu: 5.587 ± 0.026	1.819GluMet: 1.819 ± 0.013	2.784GluAsn: 2.784 ± 0.017	2.529GluPro: 2.529 ± 0.015	2.618GluGln: 2.618 ± 0.015	3.541GluArg: 3.541 ± 0.02	5.059GluSer: 5.059 ± 0.024	3.388GluThr: 3.388 ± 0.018	3.984GluVal: 3.984 ± 0.021	0.598GluTrp: 0.598 ± 0.007	1.378GluTyr: 1.378 ± 0.011	0.0GluXaa: 0.0 ± 0.0
Phe	2.663PheAla: 2.663 ± 0.015	0.871PheCys: 0.871 ± 0.009	2.764PheAsp: 2.764 ± 0.014	2.557PheGlu: 2.557 ± 0.013	1.806PhePhe: 1.806 ± 0.013	2.408PheGly: 2.408 ± 0.017	0.91PheHis: 0.91 ± 0.008	1.664PheIle: 1.664 ± 0.011	1.814PheLys: 1.814 ± 0.012	3.974PheLeu: 3.974 ± 0.018	0.809PheMet: 0.809 ± 0.009	1.68PheAsn: 1.68 ± 0.01	1.863PhePro: 1.863 ± 0.013	1.614PheGln: 1.614 ± 0.012	2.262PheArg: 2.262 ± 0.013	3.883PheSer: 3.883 ± 0.02	1.882PheThr: 1.882 ± 0.021	2.655PheVal: 2.655 ± 0.014	0.453PheTrp: 0.453 ± 0.006	1.091PheTyr: 1.091 ± 0.01	0.0PheXaa: 0.0 ± 0.0
Gly	3.704GlyAla: 3.704 ± 0.022	1.253GlyCys: 1.253 ± 0.009	3.198GlyAsp: 3.198 ± 0.018	3.669GlyGlu: 3.669 ± 0.018	2.759GlyPhe: 2.759 ± 0.015	5.039GlyGly: 5.039 ± 0.036	1.336GlyHis: 1.336 ± 0.011	3.168GlyIle: 3.168 ± 0.016	3.562GlyLys: 3.562 ± 0.016	5.638GlyLeu: 5.638 ± 0.025	1.445GlyMet: 1.445 ± 0.011	2.527GlyAsn: 2.527 ± 0.014	2.573GlyPro: 2.573 ± 0.018	1.982GlyGln: 1.982 ± 0.012	3.836GlyArg: 3.836 ± 0.02	6.04GlySer: 6.04 ± 0.028	2.824GlyThr: 2.824 ± 0.017	3.727GlyVal: 3.727 ± 0.019	0.722GlyTrp: 0.722 ± 0.007	1.765GlyTyr: 1.765 ± 0.014	0.0GlyXaa: 0.0 ± 0.0
His	1.62HisAla: 1.62 ± 0.012	0.502HisCys: 0.502 ± 0.012	1.328HisAsp: 1.328 ± 0.009	1.273HisGlu: 1.273 ± 0.009	1.029HisPhe: 1.029 ± 0.009	1.601HisGly: 1.601 ± 0.013	0.762HisHis: 0.762 ± 0.009	1.112HisIle: 1.112 ± 0.009	1.178HisLys: 1.178 ± 0.009	2.29HisLeu: 2.29 ± 0.022	0.492HisMet: 0.492 ± 0.006	0.936HisAsn: 0.936 ± 0.008	1.301HisPro: 1.301 ± 0.009	1.175HisGln: 1.175 ± 0.01	1.669HisArg: 1.669 ± 0.012	1.963HisSer: 1.963 ± 0.013	1.118HisThr: 1.118 ± 0.009	1.384HisVal: 1.384 ± 0.01	0.3HisTrp: 0.3 ± 0.005	0.553HisTyr: 0.553 ± 0.007	0.0HisXaa: 0.0 ± 0.0
Ile	3.715IleAla: 3.715 ± 0.016	1.195IleCys: 1.195 ± 0.01	2.963IleAsp: 2.963 ± 0.016	3.153IleGlu: 3.153 ± 0.018	2.116IlePhe: 2.116 ± 0.013	3.225IleGly: 3.225 ± 0.019	1.491IleHis: 1.491 ± 0.011	2.475IleIle: 2.475 ± 0.014	2.506IleLys: 2.506 ± 0.014	4.819IleLeu: 4.819 ± 0.02	1.046IleMet: 1.046 ± 0.009	2.027IleAsn: 2.027 ± 0.012	3.255IlePro: 3.255 ± 0.02	2.463IleGln: 2.463 ± 0.015	2.937IleArg: 2.937 ± 0.013	5.329IleSer: 5.329 ± 0.021	2.844IleThr: 2.844 ± 0.016	3.367IleVal: 3.367 ± 0.015	0.58IleTrp: 0.58 ± 0.006	1.447IleTyr: 1.447 ± 0.011	0.0IleXaa: 0.0 ± 0.0
Lys	4.005LysAla: 4.005 ± 0.03	0.825LysCys: 0.825 ± 0.008	2.891LysAsp: 2.891 ± 0.016	4.067LysGlu: 4.067 ± 0.023	2.169LysPhe: 2.169 ± 0.012	3.268LysGly: 3.268 ± 0.016	1.154LysHis: 1.154 ± 0.02	3.317LysIle: 3.317 ± 0.016	4.964LysLys: 4.964 ± 0.031	5.045LysLeu: 5.045 ± 0.026	1.485LysMet: 1.485 ± 0.011	2.523LysAsn: 2.523 ± 0.017	2.282LysPro: 2.282 ± 0.014	2.172LysGln: 2.172 ± 0.014	3.999LysArg: 3.999 ± 0.019	4.644LysSer: 4.644 ± 0.023	2.845LysThr: 2.845 ± 0.016	3.203LysVal: 3.203 ± 0.016	0.634LysTrp: 0.634 ± 0.007	1.443LysTyr: 1.443 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	6.475LeuAla: 6.475 ± 0.027	1.699LeuCys: 1.699 ± 0.013	4.674LeuAsp: 4.674 ± 0.021	6.095LeuGlu: 6.095 ± 0.023	3.492LeuPhe: 3.492 ± 0.018	5.191LeuGly: 5.191 ± 0.02	2.46LeuHis: 2.46 ± 0.015	4.594LeuIle: 4.594 ± 0.018	5.599LeuLys: 5.599 ± 0.027	9.308LeuLeu: 9.308 ± 0.04	2.089LeuMet: 2.089 ± 0.011	3.672LeuAsn: 3.672 ± 0.017	4.765LeuPro: 4.765 ± 0.022	3.774LeuGln: 3.774 ± 0.019	5.823LeuArg: 5.823 ± 0.022	7.937LeuSer: 7.937 ± 0.03	4.374LeuThr: 4.374 ± 0.02	6.562LeuVal: 6.562 ± 0.025	0.921LeuTrp: 0.921 ± 0.009	2.012LeuTyr: 2.012 ± 0.013	0.0LeuXaa: 0.0 ± 0.0
Met	2.103MetAla: 2.103 ± 0.011	0.289MetCys: 0.289 ± 0.005	1.269MetAsp: 1.269 ± 0.01	1.641MetGlu: 1.641 ± 0.011	1.0MetPhe: 1.0 ± 0.01	1.291MetGly: 1.291 ± 0.011	0.714MetHis: 0.714 ± 0.007	1.165MetIle: 1.165 ± 0.01	1.622MetLys: 1.622 ± 0.011	2.023MetLeu: 2.023 ± 0.013	0.673MetMet: 0.673 ± 0.008	0.95MetAsn: 0.95 ± 0.009	0.905MetPro: 0.905 ± 0.008	0.875MetGln: 0.875 ± 0.009	1.387MetArg: 1.387 ± 0.011	2.004MetSer: 2.004 ± 0.013	1.191MetThr: 1.191 ± 0.01	2.025MetVal: 2.025 ± 0.013	0.201MetTrp: 0.201 ± 0.004	0.501MetTyr: 0.501 ± 0.006	0.0MetXaa: 0.0 ± 0.0
Asn	2.517AsnAla: 2.517 ± 0.015	0.667AsnCys: 0.667 ± 0.007	2.096AsnAsp: 2.096 ± 0.012	2.369AsnGlu: 2.369 ± 0.016	1.658AsnPhe: 1.658 ± 0.01	2.527AsnGly: 2.527 ± 0.017	1.186AsnHis: 1.186 ± 0.01	2.143AsnIle: 2.143 ± 0.012	2.009AsnLys: 2.009 ± 0.013	3.77AsnLeu: 3.77 ± 0.021	0.905AsnMet: 0.905 ± 0.008	1.641AsnAsn: 1.641 ± 0.014	2.143AsnPro: 2.143 ± 0.014	2.287AsnGln: 2.287 ± 0.016	2.126AsnArg: 2.126 ± 0.014	3.67AsnSer: 3.67 ± 0.02	1.91AsnThr: 1.91 ± 0.011	2.256AsnVal: 2.256 ± 0.014	0.697AsnTrp: 0.697 ± 0.006	0.993AsnTyr: 0.993 ± 0.009	0.0AsnXaa: 0.0 ± 0.0
Pro	4.163ProAla: 4.163 ± 0.025	0.827ProCys: 0.827 ± 0.008	2.393ProAsp: 2.393 ± 0.014	2.726ProGlu: 2.726 ± 0.016	1.736ProPhe: 1.736 ± 0.013	2.496ProGly: 2.496 ± 0.017	1.131ProHis: 1.131 ± 0.01	2.461ProIle: 2.461 ± 0.017	2.532ProLys: 2.532 ± 0.012	3.917ProLeu: 3.917 ± 0.021	1.021ProMet: 1.021 ± 0.009	1.889ProAsn: 1.889 ± 0.014	4.001ProPro: 4.001 ± 0.042	1.757ProGln: 1.757 ± 0.011	3.064ProArg: 3.064 ± 0.018	4.73ProSer: 4.73 ± 0.021	2.903ProThr: 2.903 ± 0.016	3.681ProVal: 3.681 ± 0.021	0.51ProTrp: 0.51 ± 0.007	1.2ProTyr: 1.2 ± 0.011	0.001ProXaa: 0.001 ± 0.0
Gln	2.91GlnAla: 2.91 ± 0.016	0.574GlnCys: 0.574 ± 0.006	1.75GlnAsp: 1.75 ± 0.011	2.587GlnGlu: 2.587 ± 0.015	1.44GlnPhe: 1.44 ± 0.01	1.987GlnGly: 1.987 ± 0.012	1.003GlnHis: 1.003 ± 0.009	2.548GlnIle: 2.548 ± 0.015	2.03GlnLys: 2.03 ± 0.013	4.291GlnLeu: 4.291 ± 0.022	1.155GlnMet: 1.155 ± 0.01	1.736GlnAsn: 1.736 ± 0.013	2.081GlnPro: 2.081 ± 0.015	2.563GlnGln: 2.563 ± 0.021	2.626GlnArg: 2.626 ± 0.016	3.253GlnSer: 3.253 ± 0.017	1.929GlnThr: 1.929 ± 0.015	2.592GlnVal: 2.592 ± 0.018	0.488GlnTrp: 0.488 ± 0.005	1.106GlnTyr: 1.106 ± 0.01	0.0GlnXaa: 0.0 ± 0.0
Arg	4.279ArgAla: 4.279 ± 0.024	1.231ArgCys: 1.231 ± 0.012	3.019ArgAsp: 3.019 ± 0.014	3.49ArgGlu: 3.49 ± 0.021	2.496ArgPhe: 2.496 ± 0.016	3.825ArgGly: 3.825 ± 0.019	1.426ArgHis: 1.426 ± 0.011	3.135ArgIle: 3.135 ± 0.014	3.989ArgLys: 3.989 ± 0.021	5.372ArgLeu: 5.372 ± 0.024	1.485ArgMet: 1.485 ± 0.01	2.564ArgAsn: 2.564 ± 0.015	3.079ArgPro: 3.079 ± 0.019	2.289ArgGln: 2.289 ± 0.012	6.093ArgArg: 6.093 ± 0.033	5.455ArgSer: 5.455 ± 0.023	3.328ArgThr: 3.328 ± 0.015	3.438ArgVal: 3.438 ± 0.017	0.977ArgTrp: 0.977 ± 0.01	1.46ArgTyr: 1.46 ± 0.012	0.0ArgXaa: 0.0 ± 0.0
Ser	6.277SerAla: 6.277 ± 0.029	1.764SerCys: 1.764 ± 0.012	4.483SerAsp: 4.483 ± 0.021	4.556SerGlu: 4.556 ± 0.021	3.675SerPhe: 3.675 ± 0.019	6.138SerGly: 6.138 ± 0.024	2.045SerHis: 2.045 ± 0.012	4.591SerIle: 4.591 ± 0.017	4.773SerLys: 4.773 ± 0.022	8.204SerLeu: 8.204 ± 0.028	2.08SerMet: 2.08 ± 0.013	3.68SerAsn: 3.68 ± 0.019	4.28SerPro: 4.28 ± 0.025	3.228SerGln: 3.228 ± 0.018	5.587SerArg: 5.587 ± 0.028	11.875SerSer: 11.875 ± 0.052	5.385SerThr: 5.385 ± 0.025	5.944SerVal: 5.944 ± 0.02	1.519SerTrp: 1.519 ± 0.012	2.074SerTyr: 2.074 ± 0.013	0.0SerXaa: 0.0 ± 0.0
Thr	4.104ThrAla: 4.104 ± 0.018	0.979ThrCys: 0.979 ± 0.008	2.809ThrAsp: 2.809 ± 0.016	3.02ThrGlu: 3.02 ± 0.019	1.823ThrPhe: 1.823 ± 0.013	3.053ThrGly: 3.053 ± 0.019	1.062ThrHis: 1.062 ± 0.01	2.987ThrIle: 2.987 ± 0.016	2.76ThrLys: 2.76 ± 0.022	4.323ThrLeu: 4.323 ± 0.019	1.451ThrMet: 1.451 ± 0.01	2.178ThrAsn: 2.178 ± 0.013	2.57ThrPro: 2.57 ± 0.018	1.954ThrGln: 1.954 ± 0.013	2.976ThrArg: 2.976 ± 0.016	5.116ThrSer: 5.116 ± 0.024	3.593ThrThr: 3.593 ± 0.026	3.827ThrVal: 3.827 ± 0.022	0.689ThrTrp: 0.689 ± 0.008	1.203ThrTyr: 1.203 ± 0.01	0.0ThrXaa: 0.0 ± 0.0
Val	5.684ValAla: 5.684 ± 0.024	1.191ValCys: 1.191 ± 0.008	4.322ValAsp: 4.322 ± 0.021	4.864ValGlu: 4.864 ± 0.021	2.55ValPhe: 2.55 ± 0.014	3.794ValGly: 3.794 ± 0.019	1.528ValHis: 1.528 ± 0.016	3.432ValIle: 3.432 ± 0.016	3.778ValLys: 3.778 ± 0.017	5.977ValLeu: 5.977 ± 0.022	1.37ValMet: 1.37 ± 0.01	2.387ValAsn: 2.387 ± 0.013	3.002ValPro: 3.002 ± 0.016	2.871ValGln: 2.871 ± 0.015	3.407ValArg: 3.407 ± 0.015	5.626ValSer: 5.626 ± 0.022	3.473ValThr: 3.473 ± 0.017	5.431ValVal: 5.431 ± 0.027	0.632ValTrp: 0.632 ± 0.008	1.535ValTyr: 1.535 ± 0.012	0.0ValXaa: 0.0 ± 0.0
Trp	0.913TrpAla: 0.913 ± 0.008	0.199TrpCys: 0.199 ± 0.004	0.527TrpAsp: 0.527 ± 0.007	0.702TrpGlu: 0.702 ± 0.007	0.78TrpPhe: 0.78 ± 0.007	0.763TrpGly: 0.763 ± 0.008	0.232TrpHis: 0.232 ± 0.004	0.681TrpIle: 0.681 ± 0.007	0.77TrpLys: 0.77 ± 0.013	1.211TrpLeu: 1.211 ± 0.009	0.306TrpMet: 0.306 ± 0.005	0.562TrpAsn: 0.562 ± 0.007	0.51TrpPro: 0.51 ± 0.007	0.326TrpGln: 0.326 ± 0.004	0.955TrpArg: 0.955 ± 0.01	0.907TrpSer: 0.907 ± 0.008	0.682TrpThr: 0.682 ± 0.008	0.685TrpVal: 0.685 ± 0.007	0.223TrpTrp: 0.223 ± 0.008	0.423TrpTyr: 0.423 ± 0.006	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.444TyrAla: 1.444 ± 0.019	0.593TyrCys: 0.593 ± 0.008	1.359TyrAsp: 1.359 ± 0.012	1.516TyrGlu: 1.516 ± 0.011	1.131TyrPhe: 1.131 ± 0.009	1.636TyrGly: 1.636 ± 0.014	0.648TyrHis: 0.648 ± 0.007	1.464TyrIle: 1.464 ± 0.01	1.192TyrLys: 1.192 ± 0.009	2.259TyrLeu: 2.259 ± 0.016	0.6TyrMet: 0.6 ± 0.007	1.089TyrAsn: 1.089 ± 0.009	1.096TyrPro: 1.096 ± 0.011	0.912TyrGln: 0.912 ± 0.009	1.566TyrArg: 1.566 ± 0.01	2.02TyrSer: 2.02 ± 0.014	1.092TyrThr: 1.092 ± 0.009	1.504TyrVal: 1.504 ± 0.011	0.348TyrTrp: 0.348 ± 0.006	0.689TyrTyr: 0.689 ± 0.007	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.154XaaXaa: 0.154 ± 0.025

Statistics based on 45898 proteins (14407823 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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