Amino acid dipepetide frequency for Litoricola lipolytica

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	13.917AlaAla: 13.917 ± 0.181	1.278AlaCys: 1.278 ± 0.042	7.36AlaAsp: 7.36 ± 0.115	6.199AlaGlu: 6.199 ± 0.105	3.78AlaPhe: 3.78 ± 0.078	10.057AlaGly: 10.057 ± 0.136	2.38AlaHis: 2.38 ± 0.06	6.05AlaIle: 6.05 ± 0.098	3.494AlaLys: 3.494 ± 0.069	14.368AlaLeu: 14.368 ± 0.188	3.405AlaMet: 3.405 ± 0.068	3.229AlaAsn: 3.229 ± 0.069	4.919AlaPro: 4.919 ± 0.098	5.255AlaGln: 5.255 ± 0.096	7.833AlaArg: 7.833 ± 0.129	6.37AlaSer: 6.37 ± 0.104	5.687AlaThr: 5.687 ± 0.109	8.569AlaVal: 8.569 ± 0.131	1.648AlaTrp: 1.648 ± 0.059	2.391AlaTyr: 2.391 ± 0.056	0.0AlaXaa: 0.0 ± 0.0
Cys	1.128CysAla: 1.128 ± 0.038	0.119CysCys: 0.119 ± 0.014	0.647CysAsp: 0.647 ± 0.029	0.489CysGlu: 0.489 ± 0.025	0.341CysPhe: 0.341 ± 0.022	0.908CysGly: 0.908 ± 0.042	0.281CysHis: 0.281 ± 0.021	0.429CysIle: 0.429 ± 0.022	0.221CysLys: 0.221 ± 0.015	0.99CysLeu: 0.99 ± 0.039	0.205CysMet: 0.205 ± 0.015	0.296CysAsn: 0.296 ± 0.02	0.529CysPro: 0.529 ± 0.03	0.437CysGln: 0.437 ± 0.022	0.576CysArg: 0.576 ± 0.029	0.529CysSer: 0.529 ± 0.029	0.477CysThr: 0.477 ± 0.027	0.855CysVal: 0.855 ± 0.037	0.15CysTrp: 0.15 ± 0.015	0.254CysTyr: 0.254 ± 0.021	0.0CysXaa: 0.0 ± 0.0
Asp	7.688AspAla: 7.688 ± 0.101	0.617AspCys: 0.617 ± 0.028	3.873AspAsp: 3.873 ± 0.086	3.338AspGlu: 3.338 ± 0.08	2.11AspPhe: 2.11 ± 0.056	5.216AspGly: 5.216 ± 0.113	1.367AspHis: 1.367 ± 0.054	3.057AspIle: 3.057 ± 0.058	1.605AspLys: 1.605 ± 0.055	6.539AspLeu: 6.539 ± 0.089	1.526AspMet: 1.526 ± 0.049	1.7AspAsn: 1.7 ± 0.058	3.291AspPro: 3.291 ± 0.07	2.936AspGln: 2.936 ± 0.068	3.761AspArg: 3.761 ± 0.074	3.249AspSer: 3.249 ± 0.081	2.868AspThr: 2.868 ± 0.075	4.284AspVal: 4.284 ± 0.08	1.104AspTrp: 1.104 ± 0.039	1.754AspTyr: 1.754 ± 0.05	0.0AspXaa: 0.0 ± 0.0
Glu	5.938GluAla: 5.938 ± 0.097	0.47GluCys: 0.47 ± 0.027	2.197GluAsp: 2.197 ± 0.056	1.81GluGlu: 1.81 ± 0.063	1.979GluPhe: 1.979 ± 0.054	3.492GluGly: 3.492 ± 0.072	1.393GluHis: 1.393 ± 0.048	2.73GluIle: 2.73 ± 0.06	1.582GluLys: 1.582 ± 0.052	6.031GluLeu: 6.031 ± 0.086	1.244GluMet: 1.244 ± 0.043	1.445GluAsn: 1.445 ± 0.05	2.423GluPro: 2.423 ± 0.075	2.711GluGln: 2.711 ± 0.073	4.4GluArg: 4.4 ± 0.084	3.007GluSer: 3.007 ± 0.078	2.714GluThr: 2.714 ± 0.063	3.877GluVal: 3.877 ± 0.081	0.793GluTrp: 0.793 ± 0.033	1.093GluTyr: 1.093 ± 0.041	0.0GluXaa: 0.0 ± 0.0
Phe	3.806PheAla: 3.806 ± 0.081	0.359PheCys: 0.359 ± 0.023	2.867PheAsp: 2.867 ± 0.065	2.378PheGlu: 2.378 ± 0.059	1.256PhePhe: 1.256 ± 0.047	3.32PheGly: 3.32 ± 0.065	0.65PheHis: 0.65 ± 0.029	1.631PheIle: 1.631 ± 0.046	1.206PheLys: 1.206 ± 0.04	2.876PheLeu: 2.876 ± 0.079	0.921PheMet: 0.921 ± 0.034	1.262PheAsn: 1.262 ± 0.045	1.263PhePro: 1.263 ± 0.042	1.218PheGln: 1.218 ± 0.041	1.65PheArg: 1.65 ± 0.052	2.248PheSer: 2.248 ± 0.061	1.762PheThr: 1.762 ± 0.043	2.763PheVal: 2.763 ± 0.066	0.538PheTrp: 0.538 ± 0.029	0.897PheTyr: 0.897 ± 0.038	0.0PheXaa: 0.0 ± 0.0
Gly	8.679GlyAla: 8.679 ± 0.131	0.952GlyCys: 0.952 ± 0.041	5.042GlyAsp: 5.042 ± 0.093	4.159GlyGlu: 4.159 ± 0.074	3.608GlyPhe: 3.608 ± 0.08	6.393GlyGly: 6.393 ± 0.108	2.019GlyHis: 2.019 ± 0.053	4.391GlyIle: 4.391 ± 0.086	2.71GlyLys: 2.71 ± 0.074	9.493GlyLeu: 9.493 ± 0.136	2.3GlyMet: 2.3 ± 0.06	2.14GlyAsn: 2.14 ± 0.07	2.878GlyPro: 2.878 ± 0.068	3.899GlyGln: 3.899 ± 0.081	5.12GlyArg: 5.12 ± 0.095	4.336GlySer: 4.336 ± 0.093	4.217GlyThr: 4.217 ± 0.094	6.754GlyVal: 6.754 ± 0.097	1.495GlyTrp: 1.495 ± 0.045	2.294GlyTyr: 2.294 ± 0.063	0.0GlyXaa: 0.0 ± 0.0
His	2.456HisAla: 2.456 ± 0.066	0.311HisCys: 0.311 ± 0.022	1.288HisAsp: 1.288 ± 0.046	1.048HisGlu: 1.048 ± 0.037	0.824HisPhe: 0.824 ± 0.034	1.866HisGly: 1.866 ± 0.053	0.6HisHis: 0.6 ± 0.029	0.952HisIle: 0.952 ± 0.039	0.512HisLys: 0.512 ± 0.027	2.256HisLeu: 2.256 ± 0.055	0.443HisMet: 0.443 ± 0.021	0.56HisAsn: 0.56 ± 0.03	1.341HisPro: 1.341 ± 0.038	1.129HisGln: 1.129 ± 0.038	1.528HisArg: 1.528 ± 0.047	1.206HisSer: 1.206 ± 0.045	0.931HisThr: 0.931 ± 0.028	1.287HisVal: 1.287 ± 0.045	0.468HisTrp: 0.468 ± 0.025	0.638HisTyr: 0.638 ± 0.032	0.0HisXaa: 0.0 ± 0.0
Ile	6.429IleAla: 6.429 ± 0.096	0.464IleCys: 0.464 ± 0.026	3.891IleAsp: 3.891 ± 0.079	3.821IleGlu: 3.821 ± 0.07	1.326IlePhe: 1.326 ± 0.054	4.672IleGly: 4.672 ± 0.09	0.985IleHis: 0.985 ± 0.034	2.072IleIle: 2.072 ± 0.06	1.826IleLys: 1.826 ± 0.053	3.675IleLeu: 3.675 ± 0.075	1.082IleMet: 1.082 ± 0.044	1.879IleAsn: 1.879 ± 0.053	2.101IlePro: 2.101 ± 0.059	2.173IleGln: 2.173 ± 0.052	2.999IleArg: 2.999 ± 0.072	2.901IleSer: 2.901 ± 0.06	2.566IleThr: 2.566 ± 0.066	3.495IleVal: 3.495 ± 0.079	0.541IleTrp: 0.541 ± 0.033	1.011IleTyr: 1.011 ± 0.036	0.0IleXaa: 0.0 ± 0.0
Lys	3.786LysAla: 3.786 ± 0.073	0.201LysCys: 0.201 ± 0.017	1.643LysAsp: 1.643 ± 0.054	1.248LysGlu: 1.248 ± 0.046	0.862LysPhe: 0.862 ± 0.039	2.408LysGly: 2.408 ± 0.061	0.712LysHis: 0.712 ± 0.032	1.426LysIle: 1.426 ± 0.047	1.211LysLys: 1.211 ± 0.05	2.894LysLeu: 2.894 ± 0.061	0.755LysMet: 0.755 ± 0.032	0.921LysAsn: 0.921 ± 0.039	1.747LysPro: 1.747 ± 0.053	1.175LysGln: 1.175 ± 0.042	2.266LysArg: 2.266 ± 0.07	1.86LysSer: 1.86 ± 0.051	1.941LysThr: 1.941 ± 0.059	2.281LysVal: 2.281 ± 0.057	0.299LysTrp: 0.299 ± 0.021	0.609LysTyr: 0.609 ± 0.025	0.0LysXaa: 0.0 ± 0.0
Leu	13.866LeuAla: 13.866 ± 0.155	1.087LeuCys: 1.087 ± 0.046	7.001LeuAsp: 7.001 ± 0.105	5.313LeuGlu: 5.313 ± 0.088	3.406LeuPhe: 3.406 ± 0.095	9.189LeuGly: 9.189 ± 0.144	1.845LeuHis: 1.845 ± 0.053	5.539LeuIle: 5.539 ± 0.1	3.5LeuLys: 3.5 ± 0.081	10.004LeuLeu: 10.004 ± 0.176	2.939LeuMet: 2.939 ± 0.063	3.659LeuAsn: 3.659 ± 0.065	5.075LeuPro: 5.075 ± 0.097	3.395LeuGln: 3.395 ± 0.074	6.084LeuArg: 6.084 ± 0.089	7.442LeuSer: 7.442 ± 0.118	6.323LeuThr: 6.323 ± 0.09	8.241LeuVal: 8.241 ± 0.138	1.448LeuTrp: 1.448 ± 0.049	2.178LeuTyr: 2.178 ± 0.055	0.0LeuXaa: 0.0 ± 0.0
Met	3.36MetAla: 3.36 ± 0.065	0.187MetCys: 0.187 ± 0.016	1.536MetAsp: 1.536 ± 0.04	0.983MetGlu: 0.983 ± 0.043	0.697MetPhe: 0.697 ± 0.031	2.251MetGly: 2.251 ± 0.062	0.483MetHis: 0.483 ± 0.029	1.27MetIle: 1.27 ± 0.046	0.919MetLys: 0.919 ± 0.032	2.396MetLeu: 2.396 ± 0.059	0.673MetMet: 0.673 ± 0.033	0.937MetAsn: 0.937 ± 0.044	1.374MetPro: 1.374 ± 0.047	1.035MetGln: 1.035 ± 0.039	1.633MetArg: 1.633 ± 0.051	1.773MetSer: 1.773 ± 0.045	1.696MetThr: 1.696 ± 0.047	1.894MetVal: 1.894 ± 0.05	0.247MetTrp: 0.247 ± 0.02	0.392MetTyr: 0.392 ± 0.022	0.0MetXaa: 0.0 ± 0.0
Asn	3.514AsnAla: 3.514 ± 0.083	0.284AsnCys: 0.284 ± 0.018	1.743AsnAsp: 1.743 ± 0.056	1.482AsnGlu: 1.482 ± 0.045	0.982AsnPhe: 0.982 ± 0.034	2.462AsnGly: 2.462 ± 0.064	0.673AsnHis: 0.673 ± 0.027	1.329AsnIle: 1.329 ± 0.048	0.837AsnLys: 0.837 ± 0.041	3.231AsnLeu: 3.231 ± 0.061	0.687AsnMet: 0.687 ± 0.033	0.957AsnAsn: 0.957 ± 0.046	2.013AsnPro: 2.013 ± 0.057	1.362AsnGln: 1.362 ± 0.049	1.892AsnArg: 1.892 ± 0.049	1.448AsnSer: 1.448 ± 0.052	1.558AsnThr: 1.558 ± 0.055	1.901AsnVal: 1.901 ± 0.061	0.483AsnTrp: 0.483 ± 0.025	0.728AsnTyr: 0.728 ± 0.031	0.0AsnXaa: 0.0 ± 0.0
Pro	5.366ProAla: 5.366 ± 0.088	0.391ProCys: 0.391 ± 0.024	3.241ProAsp: 3.241 ± 0.063	2.93ProGlu: 2.93 ± 0.089	1.602ProPhe: 1.602 ± 0.05	3.981ProGly: 3.981 ± 0.07	0.881ProHis: 0.881 ± 0.037	2.385ProIle: 2.385 ± 0.058	1.508ProLys: 1.508 ± 0.049	4.54ProLeu: 4.54 ± 0.093	1.296ProMet: 1.296 ± 0.047	1.494ProAsn: 1.494 ± 0.046	1.711ProPro: 1.711 ± 0.063	1.52ProGln: 1.52 ± 0.046	2.379ProArg: 2.379 ± 0.059	3.08ProSer: 3.08 ± 0.065	2.543ProThr: 2.543 ± 0.059	3.892ProVal: 3.892 ± 0.076	0.817ProTrp: 0.817 ± 0.036	0.994ProTyr: 0.994 ± 0.036	0.0ProXaa: 0.0 ± 0.0
Gln	5.638GlnAla: 5.638 ± 0.092	0.392GlnCys: 0.392 ± 0.021	1.745GlnAsp: 1.745 ± 0.052	1.221GlnGlu: 1.221 ± 0.041	1.407GlnPhe: 1.407 ± 0.038	3.393GlnGly: 3.393 ± 0.071	0.982GlnHis: 0.982 ± 0.037	2.222GlnIle: 2.222 ± 0.049	1.068GlnLys: 1.068 ± 0.032	4.795GlnLeu: 4.795 ± 0.095	1.079GlnMet: 1.079 ± 0.035	0.936GlnAsn: 0.936 ± 0.036	2.154GlnPro: 2.154 ± 0.062	1.927GlnGln: 1.927 ± 0.054	3.184GlnArg: 3.184 ± 0.081	2.652GlnSer: 2.652 ± 0.065	2.281GlnThr: 2.281 ± 0.059	3.47GlnVal: 3.47 ± 0.066	0.802GlnTrp: 0.802 ± 0.036	0.777GlnTyr: 0.777 ± 0.033	0.0GlnXaa: 0.0 ± 0.0
Arg	7.283ArgAla: 7.283 ± 0.118	0.598ArgCys: 0.598 ± 0.027	3.886ArgAsp: 3.886 ± 0.079	3.252ArgGlu: 3.252 ± 0.074	2.648ArgPhe: 2.648 ± 0.064	4.492ArgGly: 4.492 ± 0.076	1.502ArgHis: 1.502 ± 0.045	3.444ArgIle: 3.444 ± 0.082	1.759ArgLys: 1.759 ± 0.053	7.427ArgLeu: 7.427 ± 0.122	1.646ArgMet: 1.646 ± 0.045	1.588ArgAsn: 1.588 ± 0.044	2.707ArgPro: 2.707 ± 0.069	2.77ArgGln: 2.77 ± 0.068	4.161ArgArg: 4.161 ± 0.09	3.279ArgSer: 3.279 ± 0.076	2.85ArgThr: 2.85 ± 0.06	5.336ArgVal: 5.336 ± 0.086	1.116ArgTrp: 1.116 ± 0.042	1.713ArgTyr: 1.713 ± 0.053	0.0ArgXaa: 0.0 ± 0.0
Ser	6.84SerAla: 6.84 ± 0.11	0.471SerCys: 0.471 ± 0.025	3.55SerAsp: 3.55 ± 0.076	3.099SerGlu: 3.099 ± 0.069	2.102SerPhe: 2.102 ± 0.053	5.311SerGly: 5.311 ± 0.091	1.229SerHis: 1.229 ± 0.043	2.972SerIle: 2.972 ± 0.073	1.703SerLys: 1.703 ± 0.046	6.527SerLeu: 6.527 ± 0.108	1.539SerMet: 1.539 ± 0.05	1.713SerAsn: 1.713 ± 0.051	2.572SerPro: 2.572 ± 0.056	2.375SerGln: 2.375 ± 0.054	3.234SerArg: 3.234 ± 0.066	3.151SerSer: 3.151 ± 0.086	2.976SerThr: 2.976 ± 0.071	4.562SerVal: 4.562 ± 0.091	0.774SerTrp: 0.774 ± 0.034	1.244SerTyr: 1.244 ± 0.05	0.0SerXaa: 0.0 ± 0.0
Thr	5.589ThrAla: 5.589 ± 0.107	0.451ThrCys: 0.451 ± 0.026	3.297ThrAsp: 3.297 ± 0.077	2.565ThrGlu: 2.565 ± 0.065	1.811ThrPhe: 1.811 ± 0.049	4.682ThrGly: 4.682 ± 0.094	1.243ThrHis: 1.243 ± 0.044	2.14ThrIle: 2.14 ± 0.059	1.241ThrLys: 1.241 ± 0.039	6.945ThrLeu: 6.945 ± 0.114	0.918ThrMet: 0.918 ± 0.033	1.347ThrAsn: 1.347 ± 0.051	3.27ThrPro: 3.27 ± 0.077	2.36ThrGln: 2.36 ± 0.062	3.499ThrArg: 3.499 ± 0.075	2.518ThrSer: 2.518 ± 0.063	2.729ThrThr: 2.729 ± 0.076	3.916ThrVal: 3.916 ± 0.084	0.626ThrTrp: 0.626 ± 0.03	1.084ThrTyr: 1.084 ± 0.043	0.0ThrXaa: 0.0 ± 0.0
Val	9.148ValAla: 9.148 ± 0.135	0.761ValCys: 0.761 ± 0.032	5.026ValAsp: 5.026 ± 0.082	4.414ValGlu: 4.414 ± 0.086	2.656ValPhe: 2.656 ± 0.069	5.982ValGly: 5.982 ± 0.095	1.429ValHis: 1.429 ± 0.048	4.204ValIle: 4.204 ± 0.084	2.445ValLys: 2.445 ± 0.052	7.796ValLeu: 7.796 ± 0.13	2.23ValMet: 2.23 ± 0.051	2.46ValAsn: 2.46 ± 0.059	3.286ValPro: 3.286 ± 0.077	2.434ValGln: 2.434 ± 0.057	4.445ValArg: 4.445 ± 0.081	4.795ValSer: 4.795 ± 0.092	4.298ValThr: 4.298 ± 0.105	6.214ValVal: 6.214 ± 0.107	0.985ValTrp: 0.985 ± 0.043	1.561ValTyr: 1.561 ± 0.045	0.0ValXaa: 0.0 ± 0.0
Trp	1.415TrpAla: 1.415 ± 0.043	0.173TrpCys: 0.173 ± 0.014	0.725TrpAsp: 0.725 ± 0.039	0.514TrpGlu: 0.514 ± 0.025	0.609TrpPhe: 0.609 ± 0.028	0.931TrpGly: 0.931 ± 0.04	0.412TrpHis: 0.412 ± 0.024	0.793TrpIle: 0.793 ± 0.035	0.321TrpLys: 0.321 ± 0.02	2.088TrpLeu: 2.088 ± 0.059	0.406TrpMet: 0.406 ± 0.025	0.426TrpAsn: 0.426 ± 0.026	0.738TrpPro: 0.738 ± 0.032	0.746TrpGln: 0.746 ± 0.033	1.043TrpArg: 1.043 ± 0.039	0.825TrpSer: 0.825 ± 0.036	0.709TrpThr: 0.709 ± 0.03	1.532TrpVal: 1.532 ± 0.05	0.25TrpTrp: 0.25 ± 0.017	0.299TrpTyr: 0.299 ± 0.021	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.345TyrAla: 2.345 ± 0.056	0.295TyrCys: 0.295 ± 0.022	1.325TyrAsp: 1.325 ± 0.048	1.069TyrGlu: 1.069 ± 0.044	0.865TyrPhe: 0.865 ± 0.035	1.875TyrGly: 1.875 ± 0.054	0.576TyrHis: 0.576 ± 0.028	0.873TyrIle: 0.873 ± 0.036	0.575TyrLys: 0.575 ± 0.029	2.665TyrLeu: 2.665 ± 0.063	0.444TyrMet: 0.444 ± 0.022	0.619TyrAsn: 0.619 ± 0.031	1.16TyrPro: 1.16 ± 0.044	1.266TyrGln: 1.266 ± 0.046	1.769TyrArg: 1.769 ± 0.048	1.274TyrSer: 1.274 ± 0.044	1.102TyrThr: 1.102 ± 0.043	1.445TyrVal: 1.445 ± 0.05	0.371TyrTrp: 0.371 ± 0.024	0.61TyrTyr: 0.61 ± 0.029	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2331 proteins (732204 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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