Amino acid dipepetide frequency for Cohaesibacter marisflavi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.464AlaAla: 11.464 ± 0.12	1.04AlaCys: 1.04 ± 0.028	5.9AlaAsp: 5.9 ± 0.072	6.601AlaGlu: 6.601 ± 0.075	4.211AlaPhe: 4.211 ± 0.053	8.052AlaGly: 8.052 ± 0.084	2.05AlaHis: 2.05 ± 0.039	6.67AlaIle: 6.67 ± 0.08	4.799AlaLys: 4.799 ± 0.064	11.701AlaLeu: 11.701 ± 0.122	3.365AlaMet: 3.365 ± 0.051	3.299AlaAsn: 3.299 ± 0.051	4.267AlaPro: 4.267 ± 0.066	3.73AlaGln: 3.73 ± 0.058	5.832AlaArg: 5.832 ± 0.07	6.718AlaSer: 6.718 ± 0.073	5.157AlaThr: 5.157 ± 0.065	6.976AlaVal: 6.976 ± 0.072	1.087AlaTrp: 1.087 ± 0.027	2.549AlaTyr: 2.549 ± 0.042	0.0AlaXaa: 0.0 ± 0.0
Cys	0.898CysAla: 0.898 ± 0.026	0.14CysCys: 0.14 ± 0.01	0.578CysAsp: 0.578 ± 0.02	0.572CysGlu: 0.572 ± 0.018	0.391CysPhe: 0.391 ± 0.015	0.921CysGly: 0.921 ± 0.025	0.269CysHis: 0.269 ± 0.014	0.477CysIle: 0.477 ± 0.021	0.348CysLys: 0.348 ± 0.016	0.984CysLeu: 0.984 ± 0.028	0.22CysMet: 0.22 ± 0.012	0.282CysAsn: 0.282 ± 0.015	0.482CysPro: 0.482 ± 0.021	0.294CysGln: 0.294 ± 0.012	0.535CysArg: 0.535 ± 0.022	0.622CysSer: 0.622 ± 0.023	0.432CysThr: 0.432 ± 0.017	0.618CysVal: 0.618 ± 0.018	0.114CysTrp: 0.114 ± 0.009	0.243CysTyr: 0.243 ± 0.014	0.0CysXaa: 0.0 ± 0.0
Asp	6.077AspAla: 6.077 ± 0.068	0.578AspCys: 0.578 ± 0.022	3.354AspAsp: 3.354 ± 0.048	3.886AspGlu: 3.886 ± 0.049	2.426AspPhe: 2.426 ± 0.043	4.837AspGly: 4.837 ± 0.075	1.398AspHis: 1.398 ± 0.029	3.764AspIle: 3.764 ± 0.05	2.632AspLys: 2.632 ± 0.049	6.279AspLeu: 6.279 ± 0.069	1.696AspMet: 1.696 ± 0.035	1.708AspAsn: 1.708 ± 0.035	3.02AspPro: 3.02 ± 0.046	2.076AspGln: 2.076 ± 0.03	3.395AspArg: 3.395 ± 0.05	2.696AspSer: 2.696 ± 0.049	2.668AspThr: 2.668 ± 0.059	3.948AspVal: 3.948 ± 0.056	0.947AspTrp: 0.947 ± 0.024	1.81AspTyr: 1.81 ± 0.039	0.0AspXaa: 0.0 ± 0.0
Glu	7.434GluAla: 7.434 ± 0.081	0.426GluCys: 0.426 ± 0.015	3.537GluAsp: 3.537 ± 0.049	4.595GluGlu: 4.595 ± 0.067	1.919GluPhe: 1.919 ± 0.044	4.677GluGly: 4.677 ± 0.055	1.217GluHis: 1.217 ± 0.026	3.854GluIle: 3.854 ± 0.052	3.462GluLys: 3.462 ± 0.049	5.515GluLeu: 5.515 ± 0.065	1.854GluMet: 1.854 ± 0.036	2.083GluAsn: 2.083 ± 0.039	2.482GluPro: 2.482 ± 0.049	2.717GluGln: 2.717 ± 0.049	4.017GluArg: 4.017 ± 0.056	2.808GluSer: 2.808 ± 0.043	3.642GluThr: 3.642 ± 0.051	3.843GluVal: 3.843 ± 0.054	0.653GluTrp: 0.653 ± 0.022	1.001GluTyr: 1.001 ± 0.025	0.0GluXaa: 0.0 ± 0.0
Phe	4.273PheAla: 4.273 ± 0.052	0.49PheCys: 0.49 ± 0.015	2.758PheAsp: 2.758 ± 0.044	2.424PheGlu: 2.424 ± 0.048	1.744PhePhe: 1.744 ± 0.04	3.643PheGly: 3.643 ± 0.051	0.807PheHis: 0.807 ± 0.021	2.241PheIle: 2.241 ± 0.042	1.488PheLys: 1.488 ± 0.038	3.877PheLeu: 3.877 ± 0.059	1.047PheMet: 1.047 ± 0.03	1.281PheAsn: 1.281 ± 0.028	1.583PhePro: 1.583 ± 0.028	1.144PheGln: 1.144 ± 0.027	1.879PheArg: 1.879 ± 0.03	2.879PheSer: 2.879 ± 0.041	1.987PheThr: 1.987 ± 0.034	2.855PheVal: 2.855 ± 0.053	0.554PheTrp: 0.554 ± 0.022	1.031PheTyr: 1.031 ± 0.026	0.0PheXaa: 0.0 ± 0.0
Gly	7.69GlyAla: 7.69 ± 0.075	0.819GlyCys: 0.819 ± 0.026	4.314GlyAsp: 4.314 ± 0.078	4.566GlyGlu: 4.566 ± 0.061	3.566GlyPhe: 3.566 ± 0.052	6.242GlyGly: 6.242 ± 0.117	1.74GlyHis: 1.74 ± 0.034	4.825GlyIle: 4.825 ± 0.06	3.916GlyLys: 3.916 ± 0.056	8.428GlyLeu: 8.428 ± 0.084	2.37GlyMet: 2.37 ± 0.039	2.57GlyAsn: 2.57 ± 0.064	2.894GlyPro: 2.894 ± 0.058	2.864GlyGln: 2.864 ± 0.048	4.334GlyArg: 4.334 ± 0.053	4.756GlySer: 4.756 ± 0.065	4.102GlyThr: 4.102 ± 0.056	5.573GlyVal: 5.573 ± 0.064	1.15GlyTrp: 1.15 ± 0.032	2.4GlyTyr: 2.4 ± 0.045	0.0GlyXaa: 0.0 ± 0.0
His	1.884HisAla: 1.884 ± 0.033	0.249HisCys: 0.249 ± 0.014	1.236HisAsp: 1.236 ± 0.031	1.115HisGlu: 1.115 ± 0.025	0.967HisPhe: 0.967 ± 0.026	1.716HisGly: 1.716 ± 0.036	0.585HisHis: 0.585 ± 0.027	1.202HisIle: 1.202 ± 0.025	0.799HisLys: 0.799 ± 0.023	2.123HisLeu: 2.123 ± 0.044	0.631HisMet: 0.631 ± 0.02	0.585HisAsn: 0.585 ± 0.018	1.26HisPro: 1.26 ± 0.028	0.666HisGln: 0.666 ± 0.021	1.122HisArg: 1.122 ± 0.026	1.169HisSer: 1.169 ± 0.028	0.896HisThr: 0.896 ± 0.023	1.344HisVal: 1.344 ± 0.034	0.333HisTrp: 0.333 ± 0.016	0.652HisTyr: 0.652 ± 0.02	0.0HisXaa: 0.0 ± 0.0
Ile	6.968IleAla: 6.968 ± 0.076	0.695IleCys: 0.695 ± 0.021	3.846IleAsp: 3.846 ± 0.038	4.004IleGlu: 4.004 ± 0.052	2.331IlePhe: 2.331 ± 0.045	5.116IleGly: 5.116 ± 0.072	1.07IleHis: 1.07 ± 0.026	3.25IleIle: 3.25 ± 0.054	2.504IleLys: 2.504 ± 0.043	5.938IleLeu: 5.938 ± 0.075	1.451IleMet: 1.451 ± 0.033	1.971IleAsn: 1.971 ± 0.039	2.582IlePro: 2.582 ± 0.045	1.557IleGln: 1.557 ± 0.033	3.17IleArg: 3.17 ± 0.047	4.114IleSer: 4.114 ± 0.047	3.15IleThr: 3.15 ± 0.052	4.347IleVal: 4.347 ± 0.064	0.73IleTrp: 0.73 ± 0.022	1.448IleTyr: 1.448 ± 0.031	0.0IleXaa: 0.0 ± 0.0
Lys	5.46LysAla: 5.46 ± 0.074	0.279LysCys: 0.279 ± 0.014	2.781LysAsp: 2.781 ± 0.049	2.925LysGlu: 2.925 ± 0.051	1.191LysPhe: 1.191 ± 0.029	3.59LysGly: 3.59 ± 0.055	0.844LysHis: 0.844 ± 0.025	2.507LysIle: 2.507 ± 0.043	2.279LysLys: 2.279 ± 0.046	4.214LysLeu: 4.214 ± 0.061	1.191LysMet: 1.191 ± 0.027	1.389LysAsn: 1.389 ± 0.028	2.355LysPro: 2.355 ± 0.043	1.672LysGln: 1.672 ± 0.035	2.853LysArg: 2.853 ± 0.047	2.829LysSer: 2.829 ± 0.041	2.592LysThr: 2.592 ± 0.041	2.989LysVal: 2.989 ± 0.043	0.49LysTrp: 0.49 ± 0.016	0.865LysTyr: 0.865 ± 0.029	0.0LysXaa: 0.0 ± 0.0
Leu	11.115LeuAla: 11.115 ± 0.099	1.006LeuCys: 1.006 ± 0.028	6.062LeuAsp: 6.062 ± 0.07	6.003LeuGlu: 6.003 ± 0.058	4.237LeuPhe: 4.237 ± 0.068	7.74LeuGly: 7.74 ± 0.085	1.8LeuHis: 1.8 ± 0.035	5.848LeuIle: 5.848 ± 0.08	4.701LeuLys: 4.701 ± 0.055	9.776LeuLeu: 9.776 ± 0.121	2.773LeuMet: 2.773 ± 0.049	3.105LeuAsn: 3.105 ± 0.054	5.009LeuPro: 5.009 ± 0.067	3.11LeuGln: 3.11 ± 0.043	5.232LeuArg: 5.232 ± 0.064	7.619LeuSer: 7.619 ± 0.081	5.424LeuThr: 5.424 ± 0.069	7.084LeuVal: 7.084 ± 0.072	1.052LeuTrp: 1.052 ± 0.032	2.303LeuTyr: 2.303 ± 0.041	0.0LeuXaa: 0.0 ± 0.0
Met	3.239MetAla: 3.239 ± 0.05	0.187MetCys: 0.187 ± 0.012	1.475MetAsp: 1.475 ± 0.033	1.458MetGlu: 1.458 ± 0.033	0.808MetPhe: 0.808 ± 0.023	2.162MetGly: 2.162 ± 0.04	0.538MetHis: 0.538 ± 0.017	1.793MetIle: 1.793 ± 0.036	1.365MetLys: 1.365 ± 0.029	2.748MetLeu: 2.748 ± 0.046	0.862MetMet: 0.862 ± 0.025	0.895MetAsn: 0.895 ± 0.025	1.606MetPro: 1.606 ± 0.035	1.066MetGln: 1.066 ± 0.028	1.767MetArg: 1.767 ± 0.036	1.979MetSer: 1.979 ± 0.032	2.025MetThr: 2.025 ± 0.039	2.073MetVal: 2.073 ± 0.038	0.193MetTrp: 0.193 ± 0.012	0.361MetTyr: 0.361 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	3.368AsnAla: 3.368 ± 0.054	0.31AsnCys: 0.31 ± 0.016	1.844AsnAsp: 1.844 ± 0.051	1.837AsnGlu: 1.837 ± 0.039	1.189AsnPhe: 1.189 ± 0.032	2.803AsnGly: 2.803 ± 0.056	0.66AsnHis: 0.66 ± 0.02	1.773AsnIle: 1.773 ± 0.039	1.374AsnLys: 1.374 ± 0.033	3.101AsnLeu: 3.101 ± 0.05	0.891AsnMet: 0.891 ± 0.027	1.103AsnAsn: 1.103 ± 0.032	1.928AsnPro: 1.928 ± 0.036	1.115AsnGln: 1.115 ± 0.029	1.911AsnArg: 1.911 ± 0.041	1.827AsnSer: 1.827 ± 0.037	1.445AsnThr: 1.445 ± 0.036	2.139AsnVal: 2.139 ± 0.038	0.521AsnTrp: 0.521 ± 0.018	0.842AsnTyr: 0.842 ± 0.024	0.0AsnXaa: 0.0 ± 0.0
Pro	4.37ProAla: 4.37 ± 0.057	0.362ProCys: 0.362 ± 0.016	3.444ProAsp: 3.444 ± 0.049	3.496ProGlu: 3.496 ± 0.055	2.023ProPhe: 2.023 ± 0.035	3.154ProGly: 3.154 ± 0.053	1.048ProHis: 1.048 ± 0.029	2.586ProIle: 2.586 ± 0.043	1.967ProLys: 1.967 ± 0.037	4.308ProLeu: 4.308 ± 0.061	1.177ProMet: 1.177 ± 0.028	1.529ProAsn: 1.529 ± 0.031	1.687ProPro: 1.687 ± 0.037	1.671ProGln: 1.671 ± 0.038	1.999ProArg: 1.999 ± 0.038	2.939ProSer: 2.939 ± 0.046	2.387ProThr: 2.387 ± 0.04	3.623ProVal: 3.623 ± 0.049	0.557ProTrp: 0.557 ± 0.019	1.228ProTyr: 1.228 ± 0.03	0.0ProXaa: 0.0 ± 0.0
Gln	3.643GlnAla: 3.643 ± 0.056	0.227GlnCys: 0.227 ± 0.012	1.835GlnAsp: 1.835 ± 0.038	1.942GlnGlu: 1.942 ± 0.037	1.276GlnPhe: 1.276 ± 0.028	2.396GlnGly: 2.396 ± 0.045	0.682GlnHis: 0.682 ± 0.019	2.324GlnIle: 2.324 ± 0.036	1.721GlnLys: 1.721 ± 0.029	3.266GlnLeu: 3.266 ± 0.046	1.174GlnMet: 1.174 ± 0.025	1.18GlnAsn: 1.18 ± 0.034	1.565GlnPro: 1.565 ± 0.038	1.487GlnGln: 1.487 ± 0.041	2.05GlnArg: 2.05 ± 0.041	2.475GlnSer: 2.475 ± 0.047	2.204GlnThr: 2.204 ± 0.046	2.187GlnVal: 2.187 ± 0.043	0.423GlnTrp: 0.423 ± 0.018	0.704GlnTyr: 0.704 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	5.332ArgAla: 5.332 ± 0.056	0.473ArgCys: 0.473 ± 0.02	3.162ArgAsp: 3.162 ± 0.051	3.29ArgGlu: 3.29 ± 0.044	2.493ArgPhe: 2.493 ± 0.042	3.491ArgGly: 3.491 ± 0.049	1.283ArgHis: 1.283 ± 0.028	3.487ArgIle: 3.487 ± 0.055	2.817ArgLys: 2.817 ± 0.046	6.132ArgLeu: 6.132 ± 0.077	1.71ArgMet: 1.71 ± 0.034	1.85ArgAsn: 1.85 ± 0.035	2.409ArgPro: 2.409 ± 0.048	2.317ArgGln: 2.317 ± 0.042	3.459ArgArg: 3.459 ± 0.059	3.39ArgSer: 3.39 ± 0.043	2.629ArgThr: 2.629 ± 0.04	3.623ArgVal: 3.623 ± 0.053	0.685ArgTrp: 0.685 ± 0.023	1.581ArgTyr: 1.581 ± 0.029	0.0ArgXaa: 0.0 ± 0.0
Ser	6.205SerAla: 6.205 ± 0.083	0.587SerCys: 0.587 ± 0.022	3.813SerAsp: 3.813 ± 0.06	3.825SerGlu: 3.825 ± 0.058	2.798SerPhe: 2.798 ± 0.045	5.711SerGly: 5.711 ± 0.061	1.338SerHis: 1.338 ± 0.029	3.868SerIle: 3.868 ± 0.044	2.646SerLys: 2.646 ± 0.042	6.539SerLeu: 6.539 ± 0.075	1.848SerMet: 1.848 ± 0.037	2.101SerAsn: 2.101 ± 0.041	2.653SerPro: 2.653 ± 0.039	2.186SerGln: 2.186 ± 0.039	3.33SerArg: 3.33 ± 0.047	4.095SerSer: 4.095 ± 0.065	2.931SerThr: 2.931 ± 0.046	4.451SerVal: 4.451 ± 0.055	0.805SerTrp: 0.805 ± 0.023	1.728SerTyr: 1.728 ± 0.035	0.0SerXaa: 0.0 ± 0.0
Thr	5.114ThrAla: 5.114 ± 0.065	0.438ThrCys: 0.438 ± 0.017	2.9ThrAsp: 2.9 ± 0.045	2.866ThrGlu: 2.866 ± 0.048	2.058ThrPhe: 2.058 ± 0.036	4.644ThrGly: 4.644 ± 0.056	1.057ThrHis: 1.057 ± 0.026	3.59ThrIle: 3.59 ± 0.053	2.043ThrLys: 2.043 ± 0.037	5.679ThrLeu: 5.679 ± 0.074	1.361ThrMet: 1.361 ± 0.027	1.667ThrAsn: 1.667 ± 0.038	2.853ThrPro: 2.853 ± 0.046	1.587ThrGln: 1.587 ± 0.033	2.654ThrArg: 2.654 ± 0.041	3.234ThrSer: 3.234 ± 0.053	2.673ThrThr: 2.673 ± 0.045	3.887ThrVal: 3.887 ± 0.051	0.547ThrTrp: 0.547 ± 0.019	1.298ThrTyr: 1.298 ± 0.031	0.0ThrXaa: 0.0 ± 0.0
Val	7.544ValAla: 7.544 ± 0.084	0.7ValCys: 0.7 ± 0.022	4.077ValAsp: 4.077 ± 0.055	4.301ValGlu: 4.301 ± 0.05	2.71ValPhe: 2.71 ± 0.04	5.215ValGly: 5.215 ± 0.066	1.272ValHis: 1.272 ± 0.03	4.256ValIle: 4.256 ± 0.063	2.958ValLys: 2.958 ± 0.052	6.386ValLeu: 6.386 ± 0.087	2.016ValMet: 2.016 ± 0.037	2.185ValAsn: 2.185 ± 0.042	3.235ValPro: 3.235 ± 0.044	1.99ValGln: 1.99 ± 0.039	3.772ValArg: 3.772 ± 0.049	4.929ValSer: 4.929 ± 0.053	4.055ValThr: 4.055 ± 0.051	5.08ValVal: 5.08 ± 0.077	0.796ValTrp: 0.796 ± 0.023	1.584ValTyr: 1.584 ± 0.031	0.0ValXaa: 0.0 ± 0.0
Trp	1.05TrpAla: 1.05 ± 0.031	0.121TrpCys: 0.121 ± 0.009	0.66TrpAsp: 0.66 ± 0.019	0.572TrpGlu: 0.572 ± 0.017	0.549TrpPhe: 0.549 ± 0.018	0.84TrpGly: 0.84 ± 0.022	0.307TrpHis: 0.307 ± 0.015	0.716TrpIle: 0.716 ± 0.024	0.492TrpLys: 0.492 ± 0.018	1.422TrpLeu: 1.422 ± 0.035	0.377TrpMet: 0.377 ± 0.018	0.428TrpAsn: 0.428 ± 0.017	0.569TrpPro: 0.569 ± 0.021	0.607TrpGln: 0.607 ± 0.02	0.792TrpArg: 0.792 ± 0.022	0.796TrpSer: 0.796 ± 0.02	0.639TrpThr: 0.639 ± 0.024	0.77TrpVal: 0.77 ± 0.023	0.186TrpTrp: 0.186 ± 0.011	0.29TrpTyr: 0.29 ± 0.012	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.34TyrAla: 2.34 ± 0.041	0.293TyrCys: 0.293 ± 0.014	1.62TyrAsp: 1.62 ± 0.037	1.461TyrGlu: 1.461 ± 0.034	1.1TyrPhe: 1.1 ± 0.031	2.172TyrGly: 2.172 ± 0.046	0.564TyrHis: 0.564 ± 0.02	1.21TyrIle: 1.21 ± 0.03	0.984TyrLys: 0.984 ± 0.032	2.579TyrLeu: 2.579 ± 0.042	0.584TyrMet: 0.584 ± 0.021	0.77TyrAsn: 0.77 ± 0.024	1.116TyrPro: 1.116 ± 0.028	0.906TyrGln: 0.906 ± 0.023	1.51TyrArg: 1.51 ± 0.031	1.583TyrSer: 1.583 ± 0.037	1.111TyrThr: 1.111 ± 0.029	1.654TyrVal: 1.654 ± 0.033	0.361TyrTrp: 0.361 ± 0.018	0.727TyrTyr: 0.727 ± 0.022	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4794 proteins (1536085 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

---