Amino acid dipepetide frequency for Apiotrichum porosum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
14.537AlaAla: 14.537 ± 0.092
1.037AlaCys: 1.037 ± 0.017
5.304AlaAsp: 5.304 ± 0.041
5.881AlaGlu: 5.881 ± 0.053
3.367AlaPhe: 3.367 ± 0.032
7.365AlaGly: 7.365 ± 0.053
2.321AlaHis: 2.321 ± 0.022
4.18AlaIle: 4.18 ± 0.029
4.276AlaLys: 4.276 ± 0.04
9.049AlaLeu: 9.049 ± 0.056
2.322AlaMet: 2.322 ± 0.025
3.137AlaAsn: 3.137 ± 0.027
7.425AlaPro: 7.425 ± 0.078
3.833AlaGln: 3.833 ± 0.04
6.182AlaArg: 6.182 ± 0.045
8.711AlaSer: 8.711 ± 0.057
6.822AlaThr: 6.822 ± 0.045
6.794AlaVal: 6.794 ± 0.048
1.346AlaTrp: 1.346 ± 0.019
2.339AlaTyr: 2.339 ± 0.024
0.0AlaXaa: 0.0 ± 0.0
Cys
0.946CysAla: 0.946 ± 0.017
0.189CysCys: 0.189 ± 0.007
0.576CysAsp: 0.576 ± 0.012
0.503CysGlu: 0.503 ± 0.011
0.438CysPhe: 0.438 ± 0.012
0.875CysGly: 0.875 ± 0.015
0.273CysHis: 0.273 ± 0.008
0.538CysIle: 0.538 ± 0.014
0.4CysLys: 0.4 ± 0.009
1.024CysLeu: 1.024 ± 0.018
0.24CysMet: 0.24 ± 0.007
0.34CysAsn: 0.34 ± 0.009
0.606CysPro: 0.606 ± 0.014
0.332CysGln: 0.332 ± 0.009
0.614CysArg: 0.614 ± 0.013
0.714CysSer: 0.714 ± 0.015
0.651CysThr: 0.651 ± 0.014
0.776CysVal: 0.776 ± 0.014
0.171CysTrp: 0.171 ± 0.006
0.299CysTyr: 0.299 ± 0.009
0.0CysXaa: 0.0 ± 0.0
Asp
5.647AspAla: 5.647 ± 0.044
0.52AspCys: 0.52 ± 0.012
5.251AspAsp: 5.251 ± 0.058
4.772AspGlu: 4.772 ± 0.048
1.855AspPhe: 1.855 ± 0.021
4.32AspGly: 4.32 ± 0.036
1.288AspHis: 1.288 ± 0.016
2.534AspIle: 2.534 ± 0.026
2.481AspLys: 2.481 ± 0.025
5.011AspLeu: 5.011 ± 0.041
1.401AspMet: 1.401 ± 0.019
1.752AspAsn: 1.752 ± 0.02
3.416AspPro: 3.416 ± 0.033
1.648AspGln: 1.648 ± 0.02
3.148AspArg: 3.148 ± 0.037
3.867AspSer: 3.867 ± 0.039
3.07AspThr: 3.07 ± 0.028
4.111AspVal: 4.111 ± 0.034
0.882AspTrp: 0.882 ± 0.015
1.41AspTyr: 1.41 ± 0.02
0.0AspXaa: 0.0 ± 0.0
Glu
5.848GluAla: 5.848 ± 0.049
0.549GluCys: 0.549 ± 0.012
4.052GluAsp: 4.052 ± 0.041
4.783GluGlu: 4.783 ± 0.065
1.588GluPhe: 1.588 ± 0.022
3.772GluGly: 3.772 ± 0.034
1.408GluHis: 1.408 ± 0.018
2.299GluIle: 2.299 ± 0.026
2.519GluLys: 2.519 ± 0.033
4.896GluLeu: 4.896 ± 0.044
1.366GluMet: 1.366 ± 0.018
1.509GluAsn: 1.509 ± 0.017
2.954GluPro: 2.954 ± 0.044
2.084GluGln: 2.084 ± 0.022
4.197GluArg: 4.197 ± 0.04
3.558GluSer: 3.558 ± 0.035
3.077GluThr: 3.077 ± 0.035
3.743GluVal: 3.743 ± 0.035
0.935GluTrp: 0.935 ± 0.013
1.457GluTyr: 1.457 ± 0.02
0.0GluXaa: 0.0 ± 0.0
Phe
3.224PheAla: 3.224 ± 0.03
0.464PheCys: 0.464 ± 0.012
2.156PheAsp: 2.156 ± 0.027
1.784PheGlu: 1.784 ± 0.019
1.345PhePhe: 1.345 ± 0.022
2.851PheGly: 2.851 ± 0.043
0.792PheHis: 0.792 ± 0.014
1.522PheIle: 1.522 ± 0.021
1.277PheLys: 1.277 ± 0.02
2.874PheLeu: 2.874 ± 0.03
0.715PheMet: 0.715 ± 0.015
1.187PheAsn: 1.187 ± 0.016
1.867PhePro: 1.867 ± 0.021
1.046PheGln: 1.046 ± 0.015
1.689PheArg: 1.689 ± 0.019
2.426PheSer: 2.426 ± 0.023
2.024PheThr: 2.024 ± 0.02
2.377PheVal: 2.377 ± 0.025
0.545PheTrp: 0.545 ± 0.012
0.879PheTyr: 0.879 ± 0.015
0.0PheXaa: 0.0 ± 0.0
Gly
6.778GlyAla: 6.778 ± 0.052
0.79GlyCys: 0.79 ± 0.015
3.989GlyAsp: 3.989 ± 0.032
3.747GlyGlu: 3.747 ± 0.034
2.558GlyPhe: 2.558 ± 0.033
7.232GlyGly: 7.232 ± 0.084
1.858GlyHis: 1.858 ± 0.024
3.06GlyIle: 3.06 ± 0.03
3.301GlyLys: 3.301 ± 0.034
6.067GlyLeu: 6.067 ± 0.045
1.781GlyMet: 1.781 ± 0.027
2.266GlyAsn: 2.266 ± 0.027
3.971GlyPro: 3.971 ± 0.034
2.468GlyGln: 2.468 ± 0.03
4.356GlyArg: 4.356 ± 0.035
6.02GlySer: 6.02 ± 0.052
4.282GlyThr: 4.282 ± 0.036
4.977GlyVal: 4.977 ± 0.036
1.324GlyTrp: 1.324 ± 0.022
2.037GlyTyr: 2.037 ± 0.027
0.0GlyXaa: 0.0 ± 0.0
His
2.339HisAla: 2.339 ± 0.024
0.282HisCys: 0.282 ± 0.008
1.367HisAsp: 1.367 ± 0.018
1.257HisGlu: 1.257 ± 0.018
0.807HisPhe: 0.807 ± 0.015
1.816HisGly: 1.816 ± 0.022
1.002HisHis: 1.002 ± 0.021
1.085HisIle: 1.085 ± 0.016
0.83HisLys: 0.83 ± 0.016
2.325HisLeu: 2.325 ± 0.029
0.523HisMet: 0.523 ± 0.01
0.736HisAsn: 0.736 ± 0.014
1.924HisPro: 1.924 ± 0.027
0.911HisGln: 0.911 ± 0.016
1.518HisArg: 1.518 ± 0.019
1.834HisSer: 1.834 ± 0.027
1.409HisThr: 1.409 ± 0.018
1.605HisVal: 1.605 ± 0.024
0.346HisTrp: 0.346 ± 0.008
0.649HisTyr: 0.649 ± 0.014
0.0HisXaa: 0.0 ± 0.0
Ile
4.2IleAla: 4.2 ± 0.034
0.531IleCys: 0.531 ± 0.011
2.559IleAsp: 2.559 ± 0.025
2.343IleGlu: 2.343 ± 0.027
1.451IlePhe: 1.451 ± 0.021
2.86IleGly: 2.86 ± 0.03
0.988IleHis: 0.988 ± 0.015
1.89IleIle: 1.89 ± 0.027
1.783IleLys: 1.783 ± 0.023
3.578IleLeu: 3.578 ± 0.038
0.86IleMet: 0.86 ± 0.015
1.416IleAsn: 1.416 ± 0.019
2.773IlePro: 2.773 ± 0.023
1.345IleGln: 1.345 ± 0.018
2.251IleArg: 2.251 ± 0.026
2.784IleSer: 2.784 ± 0.028
2.448IleThr: 2.448 ± 0.023
3.129IleVal: 3.129 ± 0.03
0.539IleTrp: 0.539 ± 0.012
1.0IleTyr: 1.0 ± 0.017
0.0IleXaa: 0.0 ± 0.0
Lys
4.434LysAla: 4.434 ± 0.039
0.373LysCys: 0.373 ± 0.009
2.411LysAsp: 2.411 ± 0.025
2.614LysGlu: 2.614 ± 0.035
1.117LysPhe: 1.117 ± 0.016
2.8LysGly: 2.8 ± 0.03
1.007LysHis: 1.007 ± 0.016
1.579LysIle: 1.579 ± 0.023
2.577LysLys: 2.577 ± 0.038
3.376LysLeu: 3.376 ± 0.03
0.905LysMet: 0.905 ± 0.014
1.251LysAsn: 1.251 ± 0.021
2.488LysPro: 2.488 ± 0.032
1.409LysGln: 1.409 ± 0.019
3.159LysArg: 3.159 ± 0.029
2.605LysSer: 2.605 ± 0.028
2.433LysThr: 2.433 ± 0.023
2.748LysVal: 2.748 ± 0.03
0.631LysTrp: 0.631 ± 0.013
1.044LysTyr: 1.044 ± 0.02
0.0LysXaa: 0.0 ± 0.0
Leu
9.526LeuAla: 9.526 ± 0.06
1.066LeuCys: 1.066 ± 0.018
5.2LeuAsp: 5.2 ± 0.043
4.868LeuGlu: 4.868 ± 0.042
3.011LeuPhe: 3.011 ± 0.033
6.208LeuGly: 6.208 ± 0.042
2.158LeuHis: 2.158 ± 0.023
3.295LeuIle: 3.295 ± 0.029
3.376LeuLys: 3.376 ± 0.033
7.905LeuLeu: 7.905 ± 0.059
1.704LeuMet: 1.704 ± 0.021
2.683LeuAsn: 2.683 ± 0.026
6.398LeuPro: 6.398 ± 0.042
3.186LeuGln: 3.186 ± 0.033
5.442LeuArg: 5.442 ± 0.042
6.784LeuSer: 6.784 ± 0.042
4.758LeuThr: 4.758 ± 0.036
5.992LeuVal: 5.992 ± 0.044
1.096LeuTrp: 1.096 ± 0.017
1.99LeuTyr: 1.99 ± 0.023
0.0LeuXaa: 0.0 ± 0.0
Met
2.379MetAla: 2.379 ± 0.022
0.253MetCys: 0.253 ± 0.007
1.3MetAsp: 1.3 ± 0.017
1.06MetGlu: 1.06 ± 0.018
0.746MetPhe: 0.746 ± 0.014
1.658MetGly: 1.658 ± 0.024
0.417MetHis: 0.417 ± 0.009
0.777MetIle: 0.777 ± 0.015
0.711MetLys: 0.711 ± 0.014
1.825MetLeu: 1.825 ± 0.022
0.524MetMet: 0.524 ± 0.011
0.653MetAsn: 0.653 ± 0.014
1.492MetPro: 1.492 ± 0.023
0.66MetGln: 0.66 ± 0.014
1.315MetArg: 1.315 ± 0.018
2.121MetSer: 2.121 ± 0.024
1.383MetThr: 1.383 ± 0.018
1.4MetVal: 1.4 ± 0.021
0.285MetTrp: 0.285 ± 0.009
0.544MetTyr: 0.544 ± 0.011
0.0MetXaa: 0.0 ± 0.0
Asn
3.114AsnAla: 3.114 ± 0.026
0.307AsnCys: 0.307 ± 0.009
1.737AsnAsp: 1.737 ± 0.021
1.578AsnGlu: 1.578 ± 0.018
0.995AsnPhe: 0.995 ± 0.017
2.794AsnGly: 2.794 ± 0.027
0.703AsnHis: 0.703 ± 0.013
1.417AsnIle: 1.417 ± 0.017
1.276AsnLys: 1.276 ± 0.017
2.686AsnLeu: 2.686 ± 0.029
0.722AsnMet: 0.722 ± 0.012
1.216AsnAsn: 1.216 ± 0.022
2.198AsnPro: 2.198 ± 0.022
0.983AsnGln: 0.983 ± 0.015
1.57AsnArg: 1.57 ± 0.019
2.196AsnSer: 2.196 ± 0.026
1.861AsnThr: 1.861 ± 0.018
2.287AsnVal: 2.287 ± 0.024
0.466AsnTrp: 0.466 ± 0.01
0.796AsnTyr: 0.796 ± 0.015
0.0AsnXaa: 0.0 ± 0.0
Pro
7.824ProAla: 7.824 ± 0.083
0.488ProCys: 0.488 ± 0.01
3.341ProAsp: 3.341 ± 0.03
3.731ProGlu: 3.731 ± 0.039
2.088ProPhe: 2.088 ± 0.023
4.493ProGly: 4.493 ± 0.04
1.707ProHis: 1.707 ± 0.025
2.49ProIle: 2.49 ± 0.025
2.599ProLys: 2.599 ± 0.029
5.613ProLeu: 5.613 ± 0.042
1.222ProMet: 1.222 ± 0.018
2.088ProAsn: 2.088 ± 0.021
7.566ProPro: 7.566 ± 0.114
2.498ProGln: 2.498 ± 0.034
4.151ProArg: 4.151 ± 0.042
7.008ProSer: 7.008 ± 0.071
5.3ProThr: 5.3 ± 0.045
4.651ProVal: 4.651 ± 0.04
0.736ProTrp: 0.736 ± 0.012
1.495ProTyr: 1.495 ± 0.02
0.0ProXaa: 0.0 ± 0.0
Gln
3.76GlnAla: 3.76 ± 0.044
0.377GlnCys: 0.377 ± 0.01
1.604GlnAsp: 1.604 ± 0.018
1.661GlnGlu: 1.661 ± 0.018
1.112GlnPhe: 1.112 ± 0.019
2.092GlnGly: 2.092 ± 0.023
1.074GlnHis: 1.074 ± 0.017
1.334GlnIle: 1.334 ± 0.017
1.23GlnLys: 1.23 ± 0.019
3.288GlnLeu: 3.288 ± 0.032
0.838GlnMet: 0.838 ± 0.015
0.979GlnAsn: 0.979 ± 0.017
2.653GlnPro: 2.653 ± 0.038
2.681GlnGln: 2.681 ± 0.101
2.523GlnArg: 2.523 ± 0.028
2.494GlnSer: 2.494 ± 0.027
2.048GlnThr: 2.048 ± 0.024
2.225GlnVal: 2.225 ± 0.022
0.556GlnTrp: 0.556 ± 0.012
1.015GlnTyr: 1.015 ± 0.018
0.0GlnXaa: 0.0 ± 0.0
Arg
6.142ArgAla: 6.142 ± 0.042
0.591ArgCys: 0.591 ± 0.013
3.606ArgAsp: 3.606 ± 0.041
3.661ArgGlu: 3.661 ± 0.038
1.936ArgPhe: 1.936 ± 0.021
4.056ArgGly: 4.056 ± 0.036
1.59ArgHis: 1.59 ± 0.018
2.458ArgIle: 2.458 ± 0.024
2.947ArgLys: 2.947 ± 0.027
5.466ArgLeu: 5.466 ± 0.04
1.331ArgMet: 1.331 ± 0.016
1.83ArgAsn: 1.83 ± 0.021
4.132ArgPro: 4.132 ± 0.04
2.395ArgGln: 2.395 ± 0.024
5.55ArgArg: 5.55 ± 0.049
4.723ArgSer: 4.723 ± 0.043
3.521ArgThr: 3.521 ± 0.029
3.858ArgVal: 3.858 ± 0.032
0.908ArgTrp: 0.908 ± 0.013
1.422ArgTyr: 1.422 ± 0.021
0.0ArgXaa: 0.0 ± 0.0
Ser
8.088SerAla: 8.088 ± 0.051
0.7SerCys: 0.7 ± 0.013
4.118SerAsp: 4.118 ± 0.036
3.428SerGlu: 3.428 ± 0.03
2.625SerPhe: 2.625 ± 0.028
5.764SerGly: 5.764 ± 0.046
1.89SerHis: 1.89 ± 0.023
3.063SerIle: 3.063 ± 0.028
2.913SerLys: 2.913 ± 0.028
6.716SerLeu: 6.716 ± 0.047
1.595SerMet: 1.595 ± 0.023
2.401SerAsn: 2.401 ± 0.023
6.647SerPro: 6.647 ± 0.075
2.533SerGln: 2.533 ± 0.029
4.851SerArg: 4.851 ± 0.042
8.971SerSer: 8.971 ± 0.089
5.942SerThr: 5.942 ± 0.049
4.826SerVal: 4.826 ± 0.034
1.003SerTrp: 1.003 ± 0.015
1.763SerTyr: 1.763 ± 0.023
0.0SerXaa: 0.0 ± 0.0
Thr
6.703ThrAla: 6.703 ± 0.047
0.643ThrCys: 0.643 ± 0.015
2.982ThrAsp: 2.982 ± 0.029
2.864ThrGlu: 2.864 ± 0.025
2.193ThrPhe: 2.193 ± 0.022
4.348ThrGly: 4.348 ± 0.037
1.449ThrHis: 1.449 ± 0.019
2.602ThrIle: 2.602 ± 0.028
2.264ThrLys: 2.264 ± 0.026
5.466ThrLeu: 5.466 ± 0.037
1.188ThrMet: 1.188 ± 0.017
1.862ThrAsn: 1.862 ± 0.023
5.758ThrPro: 5.758 ± 0.054
1.882ThrGln: 1.882 ± 0.021
3.312ThrArg: 3.312 ± 0.029
5.486ThrSer: 5.486 ± 0.043
4.809ThrThr: 4.809 ± 0.054
4.214ThrVal: 4.214 ± 0.031
0.831ThrTrp: 0.831 ± 0.014
1.486ThrTyr: 1.486 ± 0.021
0.0ThrXaa: 0.0 ± 0.0
Val
7.03ValAla: 7.03 ± 0.047
0.816ValCys: 0.816 ± 0.014
4.275ValAsp: 4.275 ± 0.038
3.928ValGlu: 3.928 ± 0.038
2.383ValPhe: 2.383 ± 0.029
4.588ValGly: 4.588 ± 0.037
1.629ValHis: 1.629 ± 0.019
2.88ValIle: 2.88 ± 0.028
2.73ValLys: 2.73 ± 0.03
5.998ValLeu: 5.998 ± 0.046
1.381ValMet: 1.381 ± 0.017
2.141ValAsn: 2.141 ± 0.024
4.726ValPro: 4.726 ± 0.033
2.299ValGln: 2.299 ± 0.025
3.885ValArg: 3.885 ± 0.032
4.781ValSer: 4.781 ± 0.035
4.009ValThr: 4.009 ± 0.033
5.179ValVal: 5.179 ± 0.044
0.995ValTrp: 0.995 ± 0.017
1.711ValTyr: 1.711 ± 0.022
0.0ValXaa: 0.0 ± 0.0
Trp
1.329TrpAla: 1.329 ± 0.017
0.204TrpCys: 0.204 ± 0.007
0.942TrpAsp: 0.942 ± 0.017
0.831TrpGlu: 0.831 ± 0.014
0.514TrpPhe: 0.514 ± 0.011
1.027TrpGly: 1.027 ± 0.018
0.33TrpHis: 0.33 ± 0.008
0.628TrpIle: 0.628 ± 0.013
0.608TrpLys: 0.608 ± 0.011
1.238TrpLeu: 1.238 ± 0.019
0.359TrpMet: 0.359 ± 0.009
0.547TrpAsn: 0.547 ± 0.013
0.654TrpPro: 0.654 ± 0.013
0.496TrpGln: 0.496 ± 0.011
0.98TrpArg: 0.98 ± 0.016
1.063TrpSer: 1.063 ± 0.016
0.935TrpThr: 0.935 ± 0.014
0.926TrpVal: 0.926 ± 0.015
0.303TrpTrp: 0.303 ± 0.009
0.378TrpTyr: 0.378 ± 0.01
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.379TyrAla: 2.379 ± 0.027
0.322TyrCys: 0.322 ± 0.009
1.614TyrAsp: 1.614 ± 0.022
1.298TyrGlu: 1.298 ± 0.019
0.917TyrPhe: 0.917 ± 0.019
1.945TyrGly: 1.945 ± 0.027
0.682TyrHis: 0.682 ± 0.012
1.095TyrIle: 1.095 ± 0.019
0.864TyrLys: 0.864 ± 0.013
2.247TyrLeu: 2.247 ± 0.024
0.524TyrMet: 0.524 ± 0.01
0.91TyrAsn: 0.91 ± 0.016
1.44TyrPro: 1.44 ± 0.018
0.856TyrGln: 0.856 ± 0.014
1.427TyrArg: 1.427 ± 0.02
1.691TyrSer: 1.691 ± 0.022
1.563TyrThr: 1.563 ± 0.022
1.546TyrVal: 1.546 ± 0.02
0.395TyrTrp: 0.395 ± 0.01
0.781TyrTyr: 0.781 ± 0.015
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 9145 proteins (4526824 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski