Amino acid dipepetide frequency for Madurella mycetomatis

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.402AlaAla: 11.402 ± 0.086	1.099AlaCys: 1.099 ± 0.017	4.787AlaAsp: 4.787 ± 0.034	5.835AlaGlu: 5.835 ± 0.047	3.154AlaPhe: 3.154 ± 0.027	6.889AlaGly: 6.889 ± 0.045	1.843AlaHis: 1.843 ± 0.018	4.142AlaIle: 4.142 ± 0.033	4.124AlaLys: 4.124 ± 0.034	8.309AlaLeu: 8.309 ± 0.051	2.072AlaMet: 2.072 ± 0.021	2.974AlaAsn: 2.974 ± 0.028	5.296AlaPro: 5.296 ± 0.05	3.545AlaGln: 3.545 ± 0.037	5.893AlaArg: 5.893 ± 0.038	7.491AlaSer: 7.491 ± 0.051	5.591AlaThr: 5.591 ± 0.04	6.158AlaVal: 6.158 ± 0.039	1.28AlaTrp: 1.28 ± 0.018	2.161AlaTyr: 2.161 ± 0.021	0.009AlaXaa: 0.009 ± 0.002
Cys	0.954CysAla: 0.954 ± 0.016	0.232CysCys: 0.232 ± 0.008	0.637CysAsp: 0.637 ± 0.013	0.613CysGlu: 0.613 ± 0.012	0.51CysPhe: 0.51 ± 0.011	1.003CysGly: 1.003 ± 0.019	0.323CysHis: 0.323 ± 0.008	0.66CysIle: 0.66 ± 0.012	0.456CysLys: 0.456 ± 0.01	1.227CysLeu: 1.227 ± 0.017	0.251CysMet: 0.251 ± 0.007	0.401CysAsn: 0.401 ± 0.01	0.7CysPro: 0.7 ± 0.015	0.425CysGln: 0.425 ± 0.008	0.807CysArg: 0.807 ± 0.015	0.878CysSer: 0.878 ± 0.015	0.662CysThr: 0.662 ± 0.012	0.809CysVal: 0.809 ± 0.014	0.218CysTrp: 0.218 ± 0.007	0.354CysTyr: 0.354 ± 0.009	0.002CysXaa: 0.002 ± 0.001
Asp	5.068AspAla: 5.068 ± 0.034	0.643AspCys: 0.643 ± 0.013	4.43AspAsp: 4.43 ± 0.044	4.524AspGlu: 4.524 ± 0.037	2.142AspPhe: 2.142 ± 0.023	4.681AspGly: 4.681 ± 0.032	1.204AspHis: 1.204 ± 0.016	2.845AspIle: 2.845 ± 0.029	2.324AspLys: 2.324 ± 0.025	4.924AspLeu: 4.924 ± 0.035	1.285AspMet: 1.285 ± 0.016	1.755AspAsn: 1.755 ± 0.017	3.519AspPro: 3.519 ± 0.026	1.742AspGln: 1.742 ± 0.021	3.333AspArg: 3.333 ± 0.038	3.889AspSer: 3.889 ± 0.033	2.8AspThr: 2.8 ± 0.026	3.741AspVal: 3.741 ± 0.031	0.901AspTrp: 0.901 ± 0.015	1.517AspTyr: 1.517 ± 0.019	0.006AspXaa: 0.006 ± 0.002
Glu	5.884GluAla: 5.884 ± 0.041	0.648GluCys: 0.648 ± 0.012	4.092GluAsp: 4.092 ± 0.037	5.482GluGlu: 5.482 ± 0.061	1.957GluPhe: 1.957 ± 0.021	4.136GluGly: 4.136 ± 0.032	1.342GluHis: 1.342 ± 0.019	2.769GluIle: 2.769 ± 0.025	3.354GluLys: 3.354 ± 0.033	5.333GluLeu: 5.333 ± 0.037	1.5GluMet: 1.5 ± 0.018	2.01GluAsn: 2.01 ± 0.023	3.019GluPro: 3.019 ± 0.049	2.402GluGln: 2.402 ± 0.027	4.397GluArg: 4.397 ± 0.04	3.952GluSer: 3.952 ± 0.034	3.434GluThr: 3.434 ± 0.029	3.678GluVal: 3.678 ± 0.03	0.935GluTrp: 0.935 ± 0.016	1.617GluTyr: 1.617 ± 0.02	0.004GluXaa: 0.004 ± 0.001
Phe	3.114PheAla: 3.114 ± 0.026	0.508PheCys: 0.508 ± 0.012	2.245PheAsp: 2.245 ± 0.023	2.059PheGlu: 2.059 ± 0.022	1.494PhePhe: 1.494 ± 0.023	2.806PheGly: 2.806 ± 0.029	0.846PheHis: 0.846 ± 0.016	1.596PheIle: 1.596 ± 0.018	1.35PheLys: 1.35 ± 0.019	3.357PheLeu: 3.357 ± 0.032	0.731PheMet: 0.731 ± 0.012	1.273PheAsn: 1.273 ± 0.017	1.952PhePro: 1.952 ± 0.021	1.244PheGln: 1.244 ± 0.019	2.105PheArg: 2.105 ± 0.021	2.801PheSer: 2.801 ± 0.021	2.038PheThr: 2.038 ± 0.02	2.384PheVal: 2.384 ± 0.024	0.63PheTrp: 0.63 ± 0.013	1.026PheTyr: 1.026 ± 0.014	0.002PheXaa: 0.002 ± 0.001
Gly	6.134GlyAla: 6.134 ± 0.042	0.936GlyCys: 0.936 ± 0.016	4.052GlyAsp: 4.052 ± 0.031	4.142GlyGlu: 4.142 ± 0.03	2.748GlyPhe: 2.748 ± 0.026	7.122GlyGly: 7.122 ± 0.07	1.745GlyHis: 1.745 ± 0.023	3.378GlyIle: 3.378 ± 0.03	3.445GlyLys: 3.445 ± 0.033	6.258GlyLeu: 6.258 ± 0.041	1.706GlyMet: 1.706 ± 0.018	2.594GlyAsn: 2.594 ± 0.032	3.886GlyPro: 3.886 ± 0.033	2.625GlyGln: 2.625 ± 0.024	4.857GlyArg: 4.857 ± 0.035	6.002GlySer: 6.002 ± 0.044	4.18GlyThr: 4.18 ± 0.038	4.721GlyVal: 4.721 ± 0.038	1.237GlyTrp: 1.237 ± 0.019	2.114GlyTyr: 2.114 ± 0.025	0.01GlyXaa: 0.01 ± 0.002
His	1.89HisAla: 1.89 ± 0.019	0.323HisCys: 0.323 ± 0.009	1.28HisAsp: 1.28 ± 0.017	1.255HisGlu: 1.255 ± 0.017	0.856HisPhe: 0.856 ± 0.012	1.803HisGly: 1.803 ± 0.02	0.895HisHis: 0.895 ± 0.019	1.123HisIle: 1.123 ± 0.017	0.833HisLys: 0.833 ± 0.012	2.199HisLeu: 2.199 ± 0.025	0.474HisMet: 0.474 ± 0.01	0.774HisAsn: 0.774 ± 0.013	1.726HisPro: 1.726 ± 0.023	1.026HisGln: 1.026 ± 0.018	1.599HisArg: 1.599 ± 0.017	1.681HisSer: 1.681 ± 0.018	1.173HisThr: 1.173 ± 0.015	1.408HisVal: 1.408 ± 0.016	0.331HisTrp: 0.331 ± 0.009	0.674HisTyr: 0.674 ± 0.012	0.003HisXaa: 0.003 ± 0.001
Ile	4.006IleAla: 4.006 ± 0.032	0.673IleCys: 0.673 ± 0.012	2.652IleAsp: 2.652 ± 0.021	2.641IleGlu: 2.641 ± 0.025	1.732IlePhe: 1.732 ± 0.021	2.948IleGly: 2.948 ± 0.028	1.072IleHis: 1.072 ± 0.016	2.158IleIle: 2.158 ± 0.022	1.969IleLys: 1.969 ± 0.023	4.15IleLeu: 4.15 ± 0.035	0.927IleMet: 0.927 ± 0.015	1.586IleAsn: 1.586 ± 0.019	2.878IlePro: 2.878 ± 0.027	1.678IleGln: 1.678 ± 0.02	2.845IleArg: 2.845 ± 0.025	3.292IleSer: 3.292 ± 0.027	2.623IleThr: 2.623 ± 0.026	2.97IleVal: 2.97 ± 0.032	0.709IleTrp: 0.709 ± 0.012	1.246IleTyr: 1.246 ± 0.018	0.003IleXaa: 0.003 ± 0.001
Lys	4.22LysAla: 4.22 ± 0.037	0.433LysCys: 0.433 ± 0.01	2.476LysAsp: 2.476 ± 0.028	3.085LysGlu: 3.085 ± 0.036	1.313LysPhe: 1.313 ± 0.019	2.945LysGly: 2.945 ± 0.031	1.027LysHis: 1.027 ± 0.014	1.969LysIle: 1.969 ± 0.02	2.996LysLys: 2.996 ± 0.044	3.845LysLeu: 3.845 ± 0.035	0.952LysMet: 0.952 ± 0.016	1.395LysAsn: 1.395 ± 0.019	2.677LysPro: 2.677 ± 0.032	1.666LysGln: 1.666 ± 0.022	3.36LysArg: 3.36 ± 0.029	2.905LysSer: 2.905 ± 0.029	2.648LysThr: 2.648 ± 0.027	2.638LysVal: 2.638 ± 0.026	0.632LysTrp: 0.632 ± 0.012	1.198LysTyr: 1.198 ± 0.016	0.003LysXaa: 0.003 ± 0.001
Leu	8.702LeuAla: 8.702 ± 0.049	1.184LeuCys: 1.184 ± 0.016	5.197LeuAsp: 5.197 ± 0.036	5.498LeuGlu: 5.498 ± 0.041	3.142LeuPhe: 3.142 ± 0.029	6.307LeuGly: 6.307 ± 0.037	2.146LeuHis: 2.146 ± 0.021	3.567LeuIle: 3.567 ± 0.033	3.866LeuLys: 3.866 ± 0.036	8.5LeuLeu: 8.5 ± 0.067	1.729LeuMet: 1.729 ± 0.022	2.801LeuAsn: 2.801 ± 0.027	5.695LeuPro: 5.695 ± 0.034	3.644LeuGln: 3.644 ± 0.034	6.292LeuArg: 6.292 ± 0.041	6.977LeuSer: 6.977 ± 0.047	4.704LeuThr: 4.704 ± 0.034	5.73LeuVal: 5.73 ± 0.04	1.25LeuTrp: 1.25 ± 0.022	2.2LeuTyr: 2.2 ± 0.024	0.009LeuXaa: 0.009 ± 0.002
Met	2.397MetAla: 2.397 ± 0.021	0.237MetCys: 0.237 ± 0.007	1.254MetAsp: 1.254 ± 0.017	1.252MetGlu: 1.252 ± 0.019	0.705MetPhe: 0.705 ± 0.011	1.498MetGly: 1.498 ± 0.019	0.466MetHis: 0.466 ± 0.009	0.874MetIle: 0.874 ± 0.015	0.898MetLys: 0.898 ± 0.015	1.882MetLeu: 1.882 ± 0.021	0.547MetMet: 0.547 ± 0.012	0.672MetAsn: 0.672 ± 0.013	1.284MetPro: 1.284 ± 0.018	0.804MetGln: 0.804 ± 0.014	1.35MetArg: 1.35 ± 0.016	1.705MetSer: 1.705 ± 0.018	1.253MetThr: 1.253 ± 0.016	1.364MetVal: 1.364 ± 0.019	0.276MetTrp: 0.276 ± 0.009	0.507MetTyr: 0.507 ± 0.011	0.001MetXaa: 0.001 ± 0.0
Asn	2.948AsnAla: 2.948 ± 0.026	0.426AsnCys: 0.426 ± 0.01	1.732AsnAsp: 1.732 ± 0.02	1.763AsnGlu: 1.763 ± 0.021	1.22AsnPhe: 1.22 ± 0.016	2.971AsnGly: 2.971 ± 0.033	0.783AsnHis: 0.783 ± 0.013	1.744AsnIle: 1.744 ± 0.022	1.331AsnLys: 1.331 ± 0.019	3.002AsnLeu: 3.002 ± 0.028	0.763AsnMet: 0.763 ± 0.014	1.337AsnAsn: 1.337 ± 0.027	2.443AsnPro: 2.443 ± 0.026	1.188AsnGln: 1.188 ± 0.016	1.914AsnArg: 1.914 ± 0.019	2.365AsnSer: 2.365 ± 0.024	1.889AsnThr: 1.889 ± 0.02	2.098AsnVal: 2.098 ± 0.025	0.534AsnTrp: 0.534 ± 0.009	0.915AsnTyr: 0.915 ± 0.015	0.003AsnXaa: 0.003 ± 0.001
Pro	6.232ProAla: 6.232 ± 0.06	0.552ProCys: 0.552 ± 0.013	3.52ProAsp: 3.52 ± 0.03	3.901ProGlu: 3.901 ± 0.035	2.047ProPhe: 2.047 ± 0.024	4.644ProGly: 4.644 ± 0.041	1.351ProHis: 1.351 ± 0.015	2.402ProIle: 2.402 ± 0.023	2.473ProLys: 2.473 ± 0.029	4.995ProLeu: 4.995 ± 0.039	1.06ProMet: 1.06 ± 0.014	2.125ProAsn: 2.125 ± 0.023	5.905ProPro: 5.905 ± 0.076	2.499ProGln: 2.499 ± 0.028	3.804ProArg: 3.804 ± 0.037	6.065ProSer: 6.065 ± 0.044	4.101ProThr: 4.101 ± 0.037	3.768ProVal: 3.768 ± 0.033	0.775ProTrp: 0.775 ± 0.013	1.472ProTyr: 1.472 ± 0.02	0.007ProXaa: 0.007 ± 0.001
Gln	3.553GlnAla: 3.553 ± 0.035	0.435GlnCys: 0.435 ± 0.011	1.971GlnAsp: 1.971 ± 0.024	2.29GlnGlu: 2.29 ± 0.022	1.22GlnPhe: 1.22 ± 0.019	2.441GlnGly: 2.441 ± 0.023	1.082GlnHis: 1.082 ± 0.017	1.633GlnIle: 1.633 ± 0.019	1.704GlnLys: 1.704 ± 0.02	3.432GlnLeu: 3.432 ± 0.029	0.844GlnMet: 0.844 ± 0.014	1.296GlnAsn: 1.296 ± 0.017	2.725GlnPro: 2.725 ± 0.03	2.697GlnGln: 2.697 ± 0.054	2.717GlnArg: 2.717 ± 0.027	2.811GlnSer: 2.811 ± 0.032	2.213GlnThr: 2.213 ± 0.021	2.15GlnVal: 2.15 ± 0.023	0.552GlnTrp: 0.552 ± 0.01	1.042GlnTyr: 1.042 ± 0.015	0.004GlnXaa: 0.004 ± 0.001
Arg	5.557ArgAla: 5.557 ± 0.037	0.783ArgCys: 0.783 ± 0.014	3.819ArgAsp: 3.819 ± 0.039	4.349ArgGlu: 4.349 ± 0.038	2.275ArgPhe: 2.275 ± 0.022	4.307ArgGly: 4.307 ± 0.036	1.718ArgHis: 1.718 ± 0.017	2.92ArgIle: 2.92 ± 0.026	3.349ArgLys: 3.349 ± 0.029	6.043ArgLeu: 6.043 ± 0.039	1.433ArgMet: 1.433 ± 0.019	2.257ArgAsn: 2.257 ± 0.021	3.913ArgPro: 3.913 ± 0.038	2.777ArgGln: 2.777 ± 0.026	5.855ArgArg: 5.855 ± 0.054	4.886ArgSer: 4.886 ± 0.045	3.458ArgThr: 3.458 ± 0.025	3.729ArgVal: 3.729 ± 0.026	1.047ArgTrp: 1.047 ± 0.017	1.757ArgTyr: 1.757 ± 0.02	0.007ArgXaa: 0.007 ± 0.002
Ser	6.947SerAla: 6.947 ± 0.044	0.838SerCys: 0.838 ± 0.015	3.986SerAsp: 3.986 ± 0.032	3.87SerGlu: 3.87 ± 0.031	2.838SerPhe: 2.838 ± 0.023	5.844SerGly: 5.844 ± 0.039	1.778SerHis: 1.778 ± 0.02	3.446SerIle: 3.446 ± 0.028	3.101SerLys: 3.101 ± 0.03	6.859SerLeu: 6.859 ± 0.046	1.54SerMet: 1.54 ± 0.019	2.566SerAsn: 2.566 ± 0.026	5.695SerPro: 5.695 ± 0.052	3.024SerGln: 3.024 ± 0.025	5.189SerArg: 5.189 ± 0.042	8.015SerSer: 8.015 ± 0.071	5.025SerThr: 5.025 ± 0.042	4.522SerVal: 4.522 ± 0.036	1.074SerTrp: 1.074 ± 0.017	1.89SerTyr: 1.89 ± 0.02	0.005SerXaa: 0.005 ± 0.001
Thr	5.81ThrAla: 5.81 ± 0.037	0.719ThrCys: 0.719 ± 0.014	2.715ThrAsp: 2.715 ± 0.023	2.999ThrGlu: 2.999 ± 0.029	2.075ThrPhe: 2.075 ± 0.02	4.248ThrGly: 4.248 ± 0.032	1.196ThrHis: 1.196 ± 0.015	2.796ThrIle: 2.796 ± 0.024	2.355ThrLys: 2.355 ± 0.026	5.065ThrLeu: 5.065 ± 0.037	1.12ThrMet: 1.12 ± 0.015	1.884ThrAsn: 1.884 ± 0.025	4.465ThrPro: 4.465 ± 0.043	1.949ThrGln: 1.949 ± 0.022	3.303ThrArg: 3.303 ± 0.028	4.924ThrSer: 4.924 ± 0.041	4.228ThrThr: 4.228 ± 0.053	3.829ThrVal: 3.829 ± 0.037	0.834ThrTrp: 0.834 ± 0.015	1.479ThrTyr: 1.479 ± 0.017	0.003ThrXaa: 0.003 ± 0.001
Val	5.836ValAla: 5.836 ± 0.039	0.855ValCys: 0.855 ± 0.015	3.857ValAsp: 3.857 ± 0.031	3.99ValGlu: 3.99 ± 0.033	2.484ValPhe: 2.484 ± 0.024	4.289ValGly: 4.289 ± 0.035	1.417ValHis: 1.417 ± 0.019	2.764ValIle: 2.764 ± 0.023	2.762ValLys: 2.762 ± 0.027	5.792ValLeu: 5.792 ± 0.042	1.346ValMet: 1.346 ± 0.018	2.076ValAsn: 2.076 ± 0.022	3.795ValPro: 3.795 ± 0.029	2.284ValGln: 2.284 ± 0.025	3.863ValArg: 3.863 ± 0.029	4.577ValSer: 4.577 ± 0.036	3.565ValThr: 3.565 ± 0.032	4.686ValVal: 4.686 ± 0.04	0.947ValTrp: 0.947 ± 0.016	1.74ValTyr: 1.74 ± 0.02	0.005ValXaa: 0.005 ± 0.001
Trp	1.291TrpAla: 1.291 ± 0.019	0.205TrpCys: 0.205 ± 0.006	0.968TrpAsp: 0.968 ± 0.017	0.92TrpGlu: 0.92 ± 0.015	0.54TrpPhe: 0.54 ± 0.011	0.985TrpGly: 0.985 ± 0.018	0.365TrpHis: 0.365 ± 0.01	0.728TrpIle: 0.728 ± 0.014	0.711TrpLys: 0.711 ± 0.014	1.402TrpLeu: 1.402 ± 0.019	0.366TrpMet: 0.366 ± 0.009	0.583TrpAsn: 0.583 ± 0.01	0.655TrpPro: 0.655 ± 0.012	0.566TrpGln: 0.566 ± 0.011	1.047TrpArg: 1.047 ± 0.017	1.006TrpSer: 1.006 ± 0.015	0.908TrpThr: 0.908 ± 0.015	0.945TrpVal: 0.945 ± 0.015	0.292TrpTrp: 0.292 ± 0.008	0.416TrpTyr: 0.416 ± 0.01	0.002TrpXaa: 0.002 ± 0.001
Tyr	2.102TyrAla: 2.102 ± 0.019	0.392TyrCys: 0.392 ± 0.01	1.596TyrAsp: 1.596 ± 0.02	1.47TyrGlu: 1.47 ± 0.018	1.106TyrPhe: 1.106 ± 0.016	2.017TyrGly: 2.017 ± 0.026	0.726TyrHis: 0.726 ± 0.012	1.24TyrIle: 1.24 ± 0.017	0.98TyrLys: 0.98 ± 0.015	2.56TyrLeu: 2.56 ± 0.025	0.578TyrMet: 0.578 ± 0.011	1.006TyrAsn: 1.006 ± 0.017	1.467TyrPro: 1.467 ± 0.018	1.022TyrGln: 1.022 ± 0.016	1.703TyrArg: 1.703 ± 0.018	1.822TyrSer: 1.822 ± 0.02	1.497TyrThr: 1.497 ± 0.02	1.596TyrVal: 1.596 ± 0.021	0.444TyrTrp: 0.444 ± 0.01	0.885TyrTyr: 0.885 ± 0.015	0.002TyrXaa: 0.002 ± 0.001
Xaa	0.008XaaAla: 0.008 ± 0.001	0.001XaaCys: 0.001 ± 0.001	0.006XaaAsp: 0.006 ± 0.002	0.006XaaGlu: 0.006 ± 0.002	0.002XaaPhe: 0.002 ± 0.001	0.008XaaGly: 0.008 ± 0.002	0.001XaaHis: 0.001 ± 0.001	0.004XaaIle: 0.004 ± 0.001	0.003XaaLys: 0.003 ± 0.001	0.007XaaLeu: 0.007 ± 0.002	0.002XaaMet: 0.002 ± 0.001	0.003XaaAsn: 0.003 ± 0.001	0.004XaaPro: 0.004 ± 0.001	0.003XaaGln: 0.003 ± 0.001	0.008XaaArg: 0.008 ± 0.002	0.006XaaSer: 0.006 ± 0.001	0.004XaaThr: 0.004 ± 0.001	0.007XaaVal: 0.007 ± 0.002	0.002XaaTrp: 0.002 ± 0.001	0.002XaaTyr: 0.002 ± 0.001	0.018XaaXaa: 0.018 ± 0.003

Statistics based on 9733 proteins (4853850 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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