Amino acid dipepetide frequency for Puumala virus (strain Sotkamo/V-2969/81)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.182AlaAla: 4.182 ± 0.692
1.83AlaCys: 1.83 ± 0.342
3.659AlaAsp: 3.659 ± 1.066
3.136AlaGlu: 3.136 ± 1.533
3.659AlaPhe: 3.659 ± 0.69
2.875AlaGly: 2.875 ± 0.345
1.83AlaHis: 1.83 ± 0.519
1.568AlaIle: 1.568 ± 0.637
3.136AlaLys: 3.136 ± 1.029
6.273AlaLeu: 6.273 ± 0.55
1.568AlaMet: 1.568 ± 0.632
1.568AlaAsn: 1.568 ± 0.443
2.352AlaPro: 2.352 ± 1.052
2.875AlaGln: 2.875 ± 1.193
2.352AlaArg: 2.352 ± 0.626
4.443AlaSer: 4.443 ± 0.909
2.875AlaThr: 2.875 ± 1.031
4.182AlaVal: 4.182 ± 0.764
0.784AlaTrp: 0.784 ± 0.221
2.614AlaTyr: 2.614 ± 0.774
0.0AlaXaa: 0.0 ± 0.0
Cys
1.307CysAla: 1.307 ± 0.215
0.523CysCys: 0.523 ± 0.472
0.261CysAsp: 0.261 ± 0.155
1.307CysGlu: 1.307 ± 1.179
1.83CysPhe: 1.83 ± 0.7
1.307CysGly: 1.307 ± 0.293
0.523CysHis: 0.523 ± 0.472
1.568CysIle: 1.568 ± 0.161
1.568CysLys: 1.568 ± 0.613
2.875CysLeu: 2.875 ± 1.917
0.261CysMet: 0.261 ± 0.236
1.045CysAsn: 1.045 ± 0.943
2.352CysPro: 2.352 ± 1.635
2.875CysGln: 2.875 ± 1.075
0.0CysArg: 0.0 ± 0.0
2.352CysSer: 2.352 ± 0.681
2.352CysThr: 2.352 ± 1.138
1.568CysVal: 1.568 ± 0.443
0.261CysTrp: 0.261 ± 0.236
1.045CysTyr: 1.045 ± 0.943
0.0CysXaa: 0.0 ± 0.0
Asp
2.614AspAla: 2.614 ± 0.705
1.045AspCys: 1.045 ± 0.609
5.227AspAsp: 5.227 ± 1.11
1.307AspGlu: 1.307 ± 0.774
1.307AspPhe: 1.307 ± 0.484
2.875AspGly: 2.875 ± 0.793
1.83AspHis: 1.83 ± 0.746
5.227AspIle: 5.227 ± 1.209
2.875AspLys: 2.875 ± 1.391
6.273AspLeu: 6.273 ± 1.253
1.568AspMet: 1.568 ± 0.602
2.614AspAsn: 2.614 ± 1.2
2.614AspPro: 2.614 ± 1.34
3.136AspGln: 3.136 ± 1.067
2.352AspArg: 2.352 ± 0.7
4.182AspSer: 4.182 ± 0.688
2.352AspThr: 2.352 ± 1.052
3.659AspVal: 3.659 ± 1.446
0.784AspTrp: 0.784 ± 0.803
2.091AspTyr: 2.091 ± 0.469
0.0AspXaa: 0.0 ± 0.0
Glu
2.614GluAla: 2.614 ± 0.968
2.352GluCys: 2.352 ± 0.452
2.352GluAsp: 2.352 ± 0.94
4.182GluGlu: 4.182 ± 1.667
2.352GluPhe: 2.352 ± 1.053
2.875GluGly: 2.875 ± 0.753
0.784GluHis: 0.784 ± 0.465
3.136GluIle: 3.136 ± 0.584
4.966GluLys: 4.966 ± 0.813
6.534GluLeu: 6.534 ± 0.549
1.045GluMet: 1.045 ± 1.423
1.83GluAsn: 1.83 ± 0.118
2.614GluPro: 2.614 ± 0.887
3.136GluGln: 3.136 ± 0.699
3.136GluArg: 3.136 ± 0.984
2.614GluSer: 2.614 ± 0.723
4.443GluThr: 4.443 ± 1.345
4.966GluVal: 4.966 ± 1.207
1.83GluTrp: 1.83 ± 0.118
1.568GluTyr: 1.568 ± 0.443
0.0GluXaa: 0.0 ± 0.0
Phe
2.352PheAla: 2.352 ± 0.452
1.045PheCys: 1.045 ± 0.337
1.83PheAsp: 1.83 ± 0.7
3.398PheGlu: 3.398 ± 1.305
3.398PhePhe: 3.398 ± 1.05
1.307PheGly: 1.307 ± 0.361
1.568PheHis: 1.568 ± 0.161
3.136PheIle: 3.136 ± 1.152
4.443PheLys: 4.443 ± 1.007
3.659PheLeu: 3.659 ± 1.112
1.568PheMet: 1.568 ± 1.11
3.136PheAsn: 3.136 ± 1.01
1.045PhePro: 1.045 ± 0.421
2.875PheGln: 2.875 ± 1.031
3.136PheArg: 3.136 ± 0.385
2.875PheSer: 2.875 ± 0.297
2.091PheThr: 2.091 ± 0.223
1.568PheVal: 1.568 ± 0.478
0.261PheTrp: 0.261 ± 0.155
1.307PheTyr: 1.307 ± 0.518
0.0PheXaa: 0.0 ± 0.0
Gly
2.614GlyAla: 2.614 ± 0.371
1.568GlyCys: 1.568 ± 1.076
3.398GlyAsp: 3.398 ± 0.48
2.875GlyGlu: 2.875 ± 0.897
3.136GlyPhe: 3.136 ± 0.322
1.568GlyGly: 1.568 ± 0.443
1.83GlyHis: 1.83 ± 0.556
3.398GlyIle: 3.398 ± 0.891
3.136GlyLys: 3.136 ± 0.819
7.841GlyLeu: 7.841 ± 0.61
2.352GlyMet: 2.352 ± 0.68
3.398GlyAsn: 3.398 ± 0.541
1.045GlyPro: 1.045 ± 0.609
2.614GlyGln: 2.614 ± 1.028
0.784GlyArg: 0.784 ± 0.803
4.966GlySer: 4.966 ± 1.937
2.875GlyThr: 2.875 ± 0.785
4.705GlyVal: 4.705 ± 0.595
1.568GlyTrp: 1.568 ± 1.067
1.83GlyTyr: 1.83 ± 0.556
0.0GlyXaa: 0.0 ± 0.0
His
2.875HisAla: 2.875 ± 1.115
0.523HisCys: 0.523 ± 0.837
1.568HisAsp: 1.568 ± 0.443
0.784HisGlu: 0.784 ± 0.367
1.307HisPhe: 1.307 ± 0.215
1.307HisGly: 1.307 ± 0.537
0.261HisHis: 0.261 ± 0.155
1.045HisIle: 1.045 ± 0.337
0.523HisLys: 0.523 ± 0.168
3.136HisLeu: 3.136 ± 0.703
0.261HisMet: 0.261 ± 0.155
0.523HisAsn: 0.523 ± 0.31
0.784HisPro: 0.784 ± 0.465
0.0HisGln: 0.0 ± 0.0
0.784HisArg: 0.784 ± 0.221
1.83HisSer: 1.83 ± 0.519
1.045HisThr: 1.045 ± 0.943
0.784HisVal: 0.784 ± 0.334
1.045HisTrp: 1.045 ± 0.669
0.523HisTyr: 0.523 ± 0.31
0.0HisXaa: 0.0 ± 0.0
Ile
2.614IleAla: 2.614 ± 1.075
0.523IleCys: 0.523 ± 0.168
4.705IleAsp: 4.705 ± 1.712
4.705IleGlu: 4.705 ± 0.572
2.091IlePhe: 2.091 ± 0.915
3.136IleGly: 3.136 ± 1.033
1.83IleHis: 1.83 ± 0.519
2.875IleIle: 2.875 ± 0.489
4.443IleLys: 4.443 ± 0.891
6.796IleLeu: 6.796 ± 0.645
2.352IleMet: 2.352 ± 0.825
1.83IleAsn: 1.83 ± 0.118
3.659IlePro: 3.659 ± 1.037
4.966IleGln: 4.966 ± 0.406
2.091IleArg: 2.091 ± 1.088
5.75IleSer: 5.75 ± 1.489
3.136IleThr: 3.136 ± 0.529
3.136IleVal: 3.136 ± 0.322
0.0IleTrp: 0.0 ± 0.0
1.568IleTyr: 1.568 ± 0.602
0.0IleXaa: 0.0 ± 0.0
Lys
3.398LysAla: 3.398 ± 0.378
1.045LysCys: 1.045 ± 0.609
3.136LysAsp: 3.136 ± 0.806
4.966LysGlu: 4.966 ± 1.522
2.875LysPhe: 2.875 ± 0.793
3.398LysGly: 3.398 ± 0.974
1.568LysHis: 1.568 ± 0.637
5.489LysIle: 5.489 ± 0.882
5.489LysLys: 5.489 ± 1.111
5.489LysLeu: 5.489 ± 0.907
1.307LysMet: 1.307 ± 0.215
3.136LysAsn: 3.136 ± 0.873
2.614LysPro: 2.614 ± 1.468
1.83LysGln: 1.83 ± 0.564
2.091LysArg: 2.091 ± 0.578
4.443LysSer: 4.443 ± 0.738
4.966LysThr: 4.966 ± 0.882
6.273LysVal: 6.273 ± 1.253
1.045LysTrp: 1.045 ± 1.557
3.136LysTyr: 3.136 ± 1.263
0.0LysXaa: 0.0 ± 0.0
Leu
4.966LeuAla: 4.966 ± 1.207
2.875LeuCys: 2.875 ± 0.581
6.273LeuAsp: 6.273 ± 0.979
6.534LeuGlu: 6.534 ± 1.484
4.705LeuPhe: 4.705 ± 0.731
7.318LeuGly: 7.318 ± 0.913
1.83LeuHis: 1.83 ± 0.556
8.625LeuIle: 8.625 ± 0.734
7.841LeuLys: 7.841 ± 1.288
10.193LeuLeu: 10.193 ± 1.684
3.136LeuMet: 3.136 ± 1.401
4.705LeuAsn: 4.705 ± 1.078
3.659LeuPro: 3.659 ± 0.457
4.966LeuGln: 4.966 ± 0.594
5.75LeuArg: 5.75 ± 0.941
4.966LeuSer: 4.966 ± 0.888
4.966LeuThr: 4.966 ± 1.729
5.75LeuVal: 5.75 ± 2.062
0.261LeuTrp: 0.261 ± 0.155
3.659LeuTyr: 3.659 ± 0.491
0.0LeuXaa: 0.0 ± 0.0
Met
2.614MetAla: 2.614 ± 0.833
0.523MetCys: 0.523 ± 0.472
1.568MetAsp: 1.568 ± 0.669
2.614MetGlu: 2.614 ± 0.651
0.784MetPhe: 0.784 ± 0.465
2.091MetGly: 2.091 ± 0.606
0.0MetHis: 0.0 ± 0.0
1.045MetIle: 1.045 ± 0.337
1.83MetLys: 1.83 ± 0.342
1.307MetLeu: 1.307 ± 1.895
0.261MetMet: 0.261 ± 0.57
0.784MetAsn: 0.784 ± 0.725
0.261MetPro: 0.261 ± 0.441
1.307MetGln: 1.307 ± 0.932
1.568MetArg: 1.568 ± 0.292
2.875MetSer: 2.875 ± 0.943
1.568MetThr: 1.568 ± 1.45
1.568MetVal: 1.568 ± 0.832
0.261MetTrp: 0.261 ± 0.155
0.523MetTyr: 0.523 ± 0.168
0.0MetXaa: 0.0 ± 0.0
Asn
1.568AsnAla: 1.568 ± 0.669
1.045AsnCys: 1.045 ± 0.619
1.568AsnAsp: 1.568 ± 0.443
2.352AsnGlu: 2.352 ± 0.825
2.091AsnPhe: 2.091 ± 0.686
1.83AsnGly: 1.83 ± 0.694
0.784AsnHis: 0.784 ± 0.334
3.136AsnIle: 3.136 ± 0.923
3.136AsnLys: 3.136 ± 1.535
6.796AsnLeu: 6.796 ± 2.305
0.523AsnMet: 0.523 ± 0.31
1.045AsnAsn: 1.045 ± 0.619
3.136AsnPro: 3.136 ± 0.886
1.307AsnGln: 1.307 ± 0.293
0.784AsnArg: 0.784 ± 0.221
1.045AsnSer: 1.045 ± 1.519
1.83AsnThr: 1.83 ± 1.032
2.875AsnVal: 2.875 ± 0.667
0.784AsnTrp: 0.784 ± 0.221
1.307AsnTyr: 1.307 ± 0.484
0.0AsnXaa: 0.0 ± 0.0
Pro
1.307ProAla: 1.307 ± 0.215
0.523ProCys: 0.523 ± 0.168
2.352ProAsp: 2.352 ± 2.023
2.352ProGlu: 2.352 ± 0.422
1.045ProPhe: 1.045 ± 0.234
4.443ProGly: 4.443 ± 1.808
1.045ProHis: 1.045 ± 0.943
2.875ProIle: 2.875 ± 0.389
2.091ProLys: 2.091 ± 0.909
3.398ProLeu: 3.398 ± 0.507
0.784ProMet: 0.784 ± 0.678
1.568ProAsn: 1.568 ± 0.637
1.045ProPro: 1.045 ± 0.441
0.784ProGln: 0.784 ± 0.465
1.568ProArg: 1.568 ± 0.632
3.659ProSer: 3.659 ± 0.965
4.966ProThr: 4.966 ± 1.887
2.091ProVal: 2.091 ± 0.565
0.523ProTrp: 0.523 ± 0.465
1.045ProTyr: 1.045 ± 0.343
0.0ProXaa: 0.0 ± 0.0
Gln
4.443GlnAla: 4.443 ± 0.801
1.307GlnCys: 1.307 ± 0.694
1.83GlnAsp: 1.83 ± 0.57
2.614GlnGlu: 2.614 ± 0.833
0.523GlnPhe: 0.523 ± 0.472
2.614GlnGly: 2.614 ± 1.075
2.091GlnHis: 2.091 ± 0.72
2.614GlnIle: 2.614 ± 0.266
1.83GlnLys: 1.83 ± 0.556
3.659GlnLeu: 3.659 ± 0.491
0.784GlnMet: 0.784 ± 1.575
2.091GlnAsn: 2.091 ± 0.575
2.091GlnPro: 2.091 ± 0.575
2.352GlnGln: 2.352 ± 0.732
2.875GlnArg: 2.875 ± 0.964
3.398GlnSer: 3.398 ± 0.791
3.921GlnThr: 3.921 ± 1.263
2.091GlnVal: 2.091 ± 0.231
1.568GlnTrp: 1.568 ± 0.622
1.568GlnTyr: 1.568 ± 0.632
0.0GlnXaa: 0.0 ± 0.0
Arg
1.045ArgAla: 1.045 ± 0.421
1.045ArgCys: 1.045 ± 0.234
2.875ArgAsp: 2.875 ± 0.753
3.136ArgGlu: 3.136 ± 1.66
3.398ArgPhe: 3.398 ± 0.378
2.875ArgGly: 2.875 ± 0.297
1.045ArgHis: 1.045 ± 0.421
2.091ArgIle: 2.091 ± 1.128
4.705ArgLys: 4.705 ± 1.154
3.136ArgLeu: 3.136 ± 1.491
1.568ArgMet: 1.568 ± 1.124
2.614ArgAsn: 2.614 ± 1.138
1.568ArgPro: 1.568 ± 0.292
1.568ArgGln: 1.568 ± 1.64
2.352ArgArg: 2.352 ± 1.571
2.091ArgSer: 2.091 ± 0.223
2.614ArgThr: 2.614 ± 1.003
3.659ArgVal: 3.659 ± 1.308
0.523ArgTrp: 0.523 ± 0.31
2.091ArgTyr: 2.091 ± 0.223
0.0ArgXaa: 0.0 ± 0.0
Ser
4.966SerAla: 4.966 ± 1.005
1.83SerCys: 1.83 ± 1.65
3.398SerAsp: 3.398 ± 0.675
3.659SerGlu: 3.659 ± 0.532
4.182SerPhe: 4.182 ± 0.739
4.705SerGly: 4.705 ± 0.595
0.523SerHis: 0.523 ± 0.472
3.921SerIle: 3.921 ± 0.724
5.227SerLys: 5.227 ± 1.203
8.102SerLeu: 8.102 ± 1.444
2.091SerMet: 2.091 ± 0.606
1.83SerAsn: 1.83 ± 0.808
3.136SerPro: 3.136 ± 0.703
2.091SerGln: 2.091 ± 0.72
4.182SerArg: 4.182 ± 0.511
4.705SerSer: 4.705 ± 1.944
4.705SerThr: 4.705 ± 0.904
3.659SerVal: 3.659 ± 1.112
0.523SerTrp: 0.523 ± 0.31
1.568SerTyr: 1.568 ± 0.161
0.0SerXaa: 0.0 ± 0.0
Thr
5.489ThrAla: 5.489 ± 1.026
1.568ThrCys: 1.568 ± 0.832
2.614ThrAsp: 2.614 ± 0.365
3.659ThrGlu: 3.659 ± 1.308
2.614ThrPhe: 2.614 ± 0.774
4.705ThrGly: 4.705 ± 1.89
0.523ThrHis: 0.523 ± 0.759
4.966ThrIle: 4.966 ± 0.629
3.136ThrLys: 3.136 ± 1.151
4.966ThrLeu: 4.966 ± 1.045
1.83ThrMet: 1.83 ± 0.694
1.045ThrAsn: 1.045 ± 0.669
2.352ThrPro: 2.352 ± 0.732
3.398ThrGln: 3.398 ± 0.801
2.875ThrArg: 2.875 ± 2.186
4.705ThrSer: 4.705 ± 1.875
4.705ThrThr: 4.705 ± 1.696
5.227ThrVal: 5.227 ± 1.157
1.045ThrTrp: 1.045 ± 0.337
1.83ThrTyr: 1.83 ± 0.519
0.0ThrXaa: 0.0 ± 0.0
Val
3.659ValAla: 3.659 ± 0.627
3.659ValCys: 3.659 ± 2.671
3.921ValAsp: 3.921 ± 0.623
3.398ValGlu: 3.398 ± 0.741
2.614ValPhe: 2.614 ± 0.515
2.614ValGly: 2.614 ± 1.028
0.0ValHis: 0.0 ± 0.0
3.398ValIle: 3.398 ± 0.48
4.182ValLys: 4.182 ± 0.988
7.58ValLeu: 7.58 ± 1.314
0.523ValMet: 0.523 ± 0.375
2.875ValAsn: 2.875 ± 0.297
1.83ValPro: 1.83 ± 0.519
2.352ValGln: 2.352 ± 0.664
3.921ValArg: 3.921 ± 1.282
4.966ValSer: 4.966 ± 0.406
4.705ValThr: 4.705 ± 1.453
3.398ValVal: 3.398 ± 0.993
1.568ValTrp: 1.568 ± 0.505
3.659ValTyr: 3.659 ± 0.592
0.0ValXaa: 0.0 ± 0.0
Trp
1.568TrpAla: 1.568 ± 0.505
1.045TrpCys: 1.045 ± 0.337
0.523TrpAsp: 0.523 ± 0.31
0.261TrpGlu: 0.261 ± 0.236
1.045TrpPhe: 1.045 ± 0.343
1.307TrpGly: 1.307 ± 0.293
0.523TrpHis: 0.523 ± 0.31
0.523TrpIle: 0.523 ± 0.837
0.784TrpLys: 0.784 ± 0.725
1.045TrpLeu: 1.045 ± 0.619
0.523TrpMet: 0.523 ± 0.472
0.0TrpAsn: 0.0 ± 0.0
0.261TrpPro: 0.261 ± 0.155
0.523TrpGln: 0.523 ± 0.837
0.784TrpArg: 0.784 ± 0.725
1.568TrpSer: 1.568 ± 0.637
1.045TrpThr: 1.045 ± 1.041
1.568TrpVal: 1.568 ± 0.161
0.0TrpTrp: 0.0 ± 0.0
0.261TrpTyr: 0.261 ± 0.441
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.568TyrAla: 1.568 ± 0.292
1.307TyrCys: 1.307 ± 0.537
2.875TyrAsp: 2.875 ± 1.115
2.091TyrGlu: 2.091 ± 0.915
1.045TyrPhe: 1.045 ± 0.421
2.352TyrGly: 2.352 ± 0.365
0.523TyrHis: 0.523 ± 0.31
1.83TyrIle: 1.83 ± 0.782
2.352TyrLys: 2.352 ± 0.365
3.921TyrLeu: 3.921 ± 0.724
0.784TyrMet: 0.784 ± 0.364
1.307TyrAsn: 1.307 ± 0.484
1.045TyrPro: 1.045 ± 0.343
1.307TyrGln: 1.307 ± 0.215
2.614TyrArg: 2.614 ± 0.723
1.568TyrSer: 1.568 ± 0.632
2.091TyrThr: 2.091 ± 0.565
2.091TyrVal: 2.091 ± 0.99
0.523TyrTrp: 0.523 ± 0.31
1.045TyrTyr: 1.045 ± 0.343
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (3827 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski