Amino acid dipepetide frequency for Aeromonas phage 4_4512

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
12.237AlaAla: 12.237 ± 1.109
1.579AlaCys: 1.579 ± 0.391
5.289AlaAsp: 5.289 ± 0.569
7.737AlaGlu: 7.737 ± 0.825
3.237AlaPhe: 3.237 ± 0.415
8.921AlaGly: 8.921 ± 1.025
1.895AlaHis: 1.895 ± 0.348
7.5AlaIle: 7.5 ± 0.998
5.289AlaLys: 5.289 ± 0.69
8.605AlaLeu: 8.605 ± 1.021
2.684AlaMet: 2.684 ± 0.581
4.263AlaAsn: 4.263 ± 0.611
3.631AlaPro: 3.631 ± 0.5
5.289AlaGln: 5.289 ± 0.792
4.816AlaArg: 4.816 ± 0.671
6.316AlaSer: 6.316 ± 0.632
6.079AlaThr: 6.079 ± 0.806
5.842AlaVal: 5.842 ± 0.773
1.658AlaTrp: 1.658 ± 0.36
2.684AlaTyr: 2.684 ± 0.405
0.0AlaXaa: 0.0 ± 0.0
Cys
0.947CysAla: 0.947 ± 0.326
0.237CysCys: 0.237 ± 0.15
0.868CysAsp: 0.868 ± 0.282
1.026CysGlu: 1.026 ± 0.276
0.316CysPhe: 0.316 ± 0.178
1.5CysGly: 1.5 ± 0.349
0.237CysHis: 0.237 ± 0.146
0.789CysIle: 0.789 ± 0.241
0.553CysLys: 0.553 ± 0.196
0.868CysLeu: 0.868 ± 0.266
0.158CysMet: 0.158 ± 0.112
0.789CysAsn: 0.789 ± 0.241
0.395CysPro: 0.395 ± 0.211
0.395CysGln: 0.395 ± 0.169
0.789CysArg: 0.789 ± 0.267
0.947CysSer: 0.947 ± 0.299
0.789CysThr: 0.789 ± 0.228
0.868CysVal: 0.868 ± 0.291
0.237CysTrp: 0.237 ± 0.134
0.474CysTyr: 0.474 ± 0.181
0.0CysXaa: 0.0 ± 0.0
Asp
6.631AspAla: 6.631 ± 0.937
0.711AspCys: 0.711 ± 0.331
4.342AspAsp: 4.342 ± 0.703
3.395AspGlu: 3.395 ± 0.52
1.737AspPhe: 1.737 ± 0.373
7.263AspGly: 7.263 ± 0.934
0.868AspHis: 0.868 ± 0.315
3.237AspIle: 3.237 ± 0.471
3.079AspLys: 3.079 ± 0.507
4.816AspLeu: 4.816 ± 0.702
1.816AspMet: 1.816 ± 0.303
2.368AspAsn: 2.368 ± 0.409
2.526AspPro: 2.526 ± 0.526
2.053AspGln: 2.053 ± 0.473
2.763AspArg: 2.763 ± 0.455
4.026AspSer: 4.026 ± 0.645
2.447AspThr: 2.447 ± 0.419
3.631AspVal: 3.631 ± 0.596
1.421AspTrp: 1.421 ± 0.397
1.895AspTyr: 1.895 ± 0.35
0.0AspXaa: 0.0 ± 0.0
Glu
6.079GluAla: 6.079 ± 0.655
0.632GluCys: 0.632 ± 0.262
2.684GluAsp: 2.684 ± 0.424
3.237GluGlu: 3.237 ± 0.607
2.921GluPhe: 2.921 ± 0.485
3.631GluGly: 3.631 ± 0.429
1.105GluHis: 1.105 ± 0.296
4.105GluIle: 4.105 ± 0.695
2.921GluLys: 2.921 ± 0.617
5.763GluLeu: 5.763 ± 0.674
3.158GluMet: 3.158 ± 0.551
2.132GluAsn: 2.132 ± 0.416
1.737GluPro: 1.737 ± 0.39
3.789GluGln: 3.789 ± 0.591
4.184GluArg: 4.184 ± 0.759
4.184GluSer: 4.184 ± 0.613
1.895GluThr: 1.895 ± 0.496
3.237GluVal: 3.237 ± 0.492
1.816GluTrp: 1.816 ± 0.406
2.526GluTyr: 2.526 ± 0.487
0.0GluXaa: 0.0 ± 0.0
Phe
3.316PheAla: 3.316 ± 0.481
0.947PheCys: 0.947 ± 0.291
3.631PheAsp: 3.631 ± 0.589
1.895PheGlu: 1.895 ± 0.414
1.105PhePhe: 1.105 ± 0.246
2.526PheGly: 2.526 ± 0.437
0.553PheHis: 0.553 ± 0.218
1.816PheIle: 1.816 ± 0.31
2.053PheLys: 2.053 ± 0.443
2.526PheLeu: 2.526 ± 0.421
0.789PheMet: 0.789 ± 0.236
2.132PheAsn: 2.132 ± 0.418
0.711PhePro: 0.711 ± 0.215
1.026PheGln: 1.026 ± 0.244
1.974PheArg: 1.974 ± 0.344
2.842PheSer: 2.842 ± 0.562
3.0PheThr: 3.0 ± 0.543
1.421PheVal: 1.421 ± 0.372
0.474PheTrp: 0.474 ± 0.228
0.868PheTyr: 0.868 ± 0.292
0.0PheXaa: 0.0 ± 0.0
Gly
6.552GlyAla: 6.552 ± 0.826
1.026GlyCys: 1.026 ± 0.28
5.131GlyAsp: 5.131 ± 0.729
4.895GlyGlu: 4.895 ± 0.722
3.474GlyPhe: 3.474 ± 0.52
6.158GlyGly: 6.158 ± 0.895
1.026GlyHis: 1.026 ± 0.344
4.816GlyIle: 4.816 ± 0.656
3.474GlyLys: 3.474 ± 0.546
6.631GlyLeu: 6.631 ± 1.104
2.21GlyMet: 2.21 ± 0.445
4.421GlyAsn: 4.421 ± 0.703
1.895GlyPro: 1.895 ± 0.329
3.553GlyGln: 3.553 ± 0.643
4.342GlyArg: 4.342 ± 0.603
5.368GlySer: 5.368 ± 0.71
3.789GlyThr: 3.789 ± 0.593
7.342GlyVal: 7.342 ± 0.922
1.658GlyTrp: 1.658 ± 0.466
2.763GlyTyr: 2.763 ± 0.516
0.0GlyXaa: 0.0 ± 0.0
His
1.658HisAla: 1.658 ± 0.403
0.316HisCys: 0.316 ± 0.153
1.421HisAsp: 1.421 ± 0.383
1.342HisGlu: 1.342 ± 0.383
0.237HisPhe: 0.237 ± 0.133
1.263HisGly: 1.263 ± 0.348
0.632HisHis: 0.632 ± 0.277
0.711HisIle: 0.711 ± 0.214
0.868HisLys: 0.868 ± 0.244
1.816HisLeu: 1.816 ± 0.342
0.553HisMet: 0.553 ± 0.231
0.789HisAsn: 0.789 ± 0.205
0.632HisPro: 0.632 ± 0.253
0.316HisGln: 0.316 ± 0.16
0.868HisArg: 0.868 ± 0.253
1.263HisSer: 1.263 ± 0.337
0.632HisThr: 0.632 ± 0.278
0.868HisVal: 0.868 ± 0.311
0.237HisTrp: 0.237 ± 0.143
0.474HisTyr: 0.474 ± 0.222
0.0HisXaa: 0.0 ± 0.0
Ile
5.921IleAla: 5.921 ± 0.615
0.789IleCys: 0.789 ± 0.258
4.421IleAsp: 4.421 ± 0.526
4.895IleGlu: 4.895 ± 0.566
0.947IlePhe: 0.947 ± 0.254
5.21IleGly: 5.21 ± 0.73
0.868IleHis: 0.868 ± 0.24
3.0IleIle: 3.0 ± 0.526
4.184IleLys: 4.184 ± 0.49
3.395IleLeu: 3.395 ± 0.556
0.947IleMet: 0.947 ± 0.306
2.447IleAsn: 2.447 ± 0.458
2.842IlePro: 2.842 ± 0.601
2.289IleGln: 2.289 ± 0.517
3.237IleArg: 3.237 ± 0.519
3.868IleSer: 3.868 ± 0.555
4.263IleThr: 4.263 ± 0.674
2.921IleVal: 2.921 ± 0.385
0.474IleTrp: 0.474 ± 0.189
1.658IleTyr: 1.658 ± 0.372
0.0IleXaa: 0.0 ± 0.0
Lys
6.868LysAla: 6.868 ± 0.873
0.789LysCys: 0.789 ± 0.253
2.368LysAsp: 2.368 ± 0.546
2.684LysGlu: 2.684 ± 0.509
2.447LysPhe: 2.447 ± 0.442
2.842LysGly: 2.842 ± 0.527
0.947LysHis: 0.947 ± 0.236
2.447LysIle: 2.447 ± 0.433
2.763LysLys: 2.763 ± 0.614
4.579LysLeu: 4.579 ± 0.666
2.053LysMet: 2.053 ± 0.399
2.447LysAsn: 2.447 ± 0.488
3.316LysPro: 3.316 ± 0.466
2.763LysGln: 2.763 ± 0.543
3.789LysArg: 3.789 ± 0.619
3.474LysSer: 3.474 ± 0.497
2.21LysThr: 2.21 ± 0.463
2.289LysVal: 2.289 ± 0.38
0.632LysTrp: 0.632 ± 0.2
1.5LysTyr: 1.5 ± 0.38
0.0LysXaa: 0.0 ± 0.0
Leu
8.842LeuAla: 8.842 ± 0.964
0.632LeuCys: 0.632 ± 0.223
4.895LeuAsp: 4.895 ± 0.719
4.184LeuGlu: 4.184 ± 0.629
2.526LeuPhe: 2.526 ± 0.481
5.605LeuGly: 5.605 ± 0.952
1.737LeuHis: 1.737 ± 0.404
3.789LeuIle: 3.789 ± 0.649
4.105LeuLys: 4.105 ± 0.575
4.658LeuLeu: 4.658 ± 0.643
2.447LeuMet: 2.447 ± 0.51
3.947LeuAsn: 3.947 ± 0.613
3.553LeuPro: 3.553 ± 0.462
3.316LeuGln: 3.316 ± 0.651
4.263LeuArg: 4.263 ± 0.697
4.974LeuSer: 4.974 ± 0.51
4.421LeuThr: 4.421 ± 0.687
5.447LeuVal: 5.447 ± 0.71
1.026LeuTrp: 1.026 ± 0.34
1.184LeuTyr: 1.184 ± 0.285
0.0LeuXaa: 0.0 ± 0.0
Met
4.105MetAla: 4.105 ± 0.515
0.395MetCys: 0.395 ± 0.2
0.711MetAsp: 0.711 ± 0.213
1.974MetGlu: 1.974 ± 0.37
0.553MetPhe: 0.553 ± 0.227
2.368MetGly: 2.368 ± 0.391
0.395MetHis: 0.395 ± 0.195
1.658MetIle: 1.658 ± 0.466
1.342MetLys: 1.342 ± 0.327
2.605MetLeu: 2.605 ± 0.573
1.026MetMet: 1.026 ± 0.39
1.184MetAsn: 1.184 ± 0.27
1.579MetPro: 1.579 ± 0.328
1.737MetGln: 1.737 ± 0.43
2.289MetArg: 2.289 ± 0.448
2.447MetSer: 2.447 ± 0.394
2.21MetThr: 2.21 ± 0.526
1.579MetVal: 1.579 ± 0.424
0.316MetTrp: 0.316 ± 0.171
0.474MetTyr: 0.474 ± 0.212
0.0MetXaa: 0.0 ± 0.0
Asn
4.421AsnAla: 4.421 ± 0.584
0.474AsnCys: 0.474 ± 0.173
2.368AsnAsp: 2.368 ± 0.399
2.605AsnGlu: 2.605 ± 0.418
1.658AsnPhe: 1.658 ± 0.397
3.947AsnGly: 3.947 ± 0.608
0.474AsnHis: 0.474 ± 0.209
2.053AsnIle: 2.053 ± 0.355
2.842AsnLys: 2.842 ± 0.514
2.526AsnLeu: 2.526 ± 0.472
1.5AsnMet: 1.5 ± 0.425
1.895AsnAsn: 1.895 ± 0.412
3.553AsnPro: 3.553 ± 0.466
1.737AsnGln: 1.737 ± 0.286
2.684AsnArg: 2.684 ± 0.554
2.368AsnSer: 2.368 ± 0.412
1.895AsnThr: 1.895 ± 0.413
1.974AsnVal: 1.974 ± 0.351
0.632AsnTrp: 0.632 ± 0.201
0.947AsnTyr: 0.947 ± 0.345
0.0AsnXaa: 0.0 ± 0.0
Pro
4.342ProAla: 4.342 ± 0.454
0.237ProCys: 0.237 ± 0.134
3.395ProAsp: 3.395 ± 0.462
3.474ProGlu: 3.474 ± 0.624
1.974ProPhe: 1.974 ± 0.347
2.842ProGly: 2.842 ± 0.454
0.632ProHis: 0.632 ± 0.193
2.447ProIle: 2.447 ± 0.378
1.737ProLys: 1.737 ± 0.389
2.132ProLeu: 2.132 ± 0.467
0.632ProMet: 0.632 ± 0.326
1.5ProAsn: 1.5 ± 0.371
1.737ProPro: 1.737 ± 0.551
2.053ProGln: 2.053 ± 0.501
1.421ProArg: 1.421 ± 0.291
3.158ProSer: 3.158 ± 0.527
3.237ProThr: 3.237 ± 0.489
2.842ProVal: 2.842 ± 0.452
0.553ProTrp: 0.553 ± 0.202
0.632ProTyr: 0.632 ± 0.21
0.0ProXaa: 0.0 ± 0.0
Gln
7.105GlnAla: 7.105 ± 1.043
0.789GlnCys: 0.789 ± 0.256
2.842GlnAsp: 2.842 ± 0.556
2.21GlnGlu: 2.21 ± 0.428
2.447GlnPhe: 2.447 ± 0.429
2.605GlnGly: 2.605 ± 0.647
0.474GlnHis: 0.474 ± 0.202
2.21GlnIle: 2.21 ± 0.457
1.895GlnLys: 1.895 ± 0.486
3.316GlnLeu: 3.316 ± 0.588
1.658GlnMet: 1.658 ± 0.408
1.263GlnAsn: 1.263 ± 0.313
1.342GlnPro: 1.342 ± 0.332
4.816GlnGln: 4.816 ± 1.459
2.447GlnArg: 2.447 ± 0.475
2.132GlnSer: 2.132 ± 0.364
1.658GlnThr: 1.658 ± 0.307
3.395GlnVal: 3.395 ± 0.476
0.868GlnTrp: 0.868 ± 0.319
1.5GlnTyr: 1.5 ± 0.324
0.0GlnXaa: 0.0 ± 0.0
Arg
4.579ArgAla: 4.579 ± 0.635
0.632ArgCys: 0.632 ± 0.235
3.631ArgAsp: 3.631 ± 0.497
3.868ArgGlu: 3.868 ± 0.631
2.289ArgPhe: 2.289 ± 0.432
4.421ArgGly: 4.421 ± 0.628
1.026ArgHis: 1.026 ± 0.259
3.789ArgIle: 3.789 ± 0.658
4.342ArgLys: 4.342 ± 0.586
4.5ArgLeu: 4.5 ± 0.637
1.816ArgMet: 1.816 ± 0.386
2.21ArgAsn: 2.21 ± 0.348
2.053ArgPro: 2.053 ± 0.384
3.0ArgGln: 3.0 ± 0.539
2.842ArgArg: 2.842 ± 0.471
2.605ArgSer: 2.605 ± 0.455
1.895ArgThr: 1.895 ± 0.355
3.237ArgVal: 3.237 ± 0.52
1.105ArgTrp: 1.105 ± 0.339
1.658ArgTyr: 1.658 ± 0.364
0.0ArgXaa: 0.0 ± 0.0
Ser
6.237SerAla: 6.237 ± 0.877
0.789SerCys: 0.789 ± 0.302
4.342SerAsp: 4.342 ± 0.621
3.316SerGlu: 3.316 ± 0.537
2.21SerPhe: 2.21 ± 0.357
5.763SerGly: 5.763 ± 0.644
1.342SerHis: 1.342 ± 0.333
4.658SerIle: 4.658 ± 0.596
3.237SerLys: 3.237 ± 0.519
5.289SerLeu: 5.289 ± 0.742
1.974SerMet: 1.974 ± 0.334
2.763SerAsn: 2.763 ± 0.461
2.368SerPro: 2.368 ± 0.429
2.921SerGln: 2.921 ± 0.658
3.947SerArg: 3.947 ± 0.439
4.421SerSer: 4.421 ± 0.771
2.921SerThr: 2.921 ± 0.683
3.631SerVal: 3.631 ± 0.486
0.789SerTrp: 0.789 ± 0.247
1.579SerTyr: 1.579 ± 0.366
0.0SerXaa: 0.0 ± 0.0
Thr
5.368ThrAla: 5.368 ± 0.739
0.395ThrCys: 0.395 ± 0.165
3.079ThrAsp: 3.079 ± 0.496
2.605ThrGlu: 2.605 ± 0.405
2.132ThrPhe: 2.132 ± 0.627
5.368ThrGly: 5.368 ± 0.963
0.553ThrHis: 0.553 ± 0.175
3.395ThrIle: 3.395 ± 0.769
2.289ThrLys: 2.289 ± 0.408
4.579ThrLeu: 4.579 ± 0.77
1.579ThrMet: 1.579 ± 0.582
2.21ThrAsn: 2.21 ± 0.419
2.289ThrPro: 2.289 ± 0.401
1.421ThrGln: 1.421 ± 0.331
2.132ThrArg: 2.132 ± 0.368
3.395ThrSer: 3.395 ± 0.619
3.474ThrThr: 3.474 ± 0.772
3.158ThrVal: 3.158 ± 0.472
0.789ThrTrp: 0.789 ± 0.226
1.737ThrTyr: 1.737 ± 0.332
0.0ThrXaa: 0.0 ± 0.0
Val
6.552ValAla: 6.552 ± 0.612
1.026ValCys: 1.026 ± 0.208
3.474ValAsp: 3.474 ± 0.424
3.316ValGlu: 3.316 ± 0.407
1.579ValPhe: 1.579 ± 0.336
5.921ValGly: 5.921 ± 0.697
0.947ValHis: 0.947 ± 0.226
4.105ValIle: 4.105 ± 0.497
4.026ValLys: 4.026 ± 0.478
2.605ValLeu: 2.605 ± 0.514
2.447ValMet: 2.447 ± 0.492
2.605ValAsn: 2.605 ± 0.498
2.684ValPro: 2.684 ± 0.404
1.737ValGln: 1.737 ± 0.34
3.158ValArg: 3.158 ± 0.499
4.421ValSer: 4.421 ± 0.662
3.71ValThr: 3.71 ± 0.635
4.184ValVal: 4.184 ± 0.63
0.553ValTrp: 0.553 ± 0.184
1.737ValTyr: 1.737 ± 0.393
0.0ValXaa: 0.0 ± 0.0
Trp
1.026TrpAla: 1.026 ± 0.25
0.553TrpCys: 0.553 ± 0.193
0.632TrpAsp: 0.632 ± 0.242
1.026TrpGlu: 1.026 ± 0.275
0.632TrpPhe: 0.632 ± 0.218
0.868TrpGly: 0.868 ± 0.213
0.947TrpHis: 0.947 ± 0.281
0.947TrpIle: 0.947 ± 0.226
1.184TrpLys: 1.184 ± 0.354
1.737TrpLeu: 1.737 ± 0.427
0.474TrpMet: 0.474 ± 0.198
0.395TrpAsn: 0.395 ± 0.189
0.947TrpPro: 0.947 ± 0.297
1.026TrpGln: 1.026 ± 0.298
1.026TrpArg: 1.026 ± 0.348
0.553TrpSer: 0.553 ± 0.177
0.316TrpThr: 0.316 ± 0.161
0.947TrpVal: 0.947 ± 0.284
0.789TrpTrp: 0.789 ± 0.218
0.632TrpTyr: 0.632 ± 0.184
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.763TyrAla: 2.763 ± 0.599
0.237TyrCys: 0.237 ± 0.113
1.5TyrAsp: 1.5 ± 0.315
2.053TyrGlu: 2.053 ± 0.563
1.184TyrPhe: 1.184 ± 0.304
1.5TyrGly: 1.5 ± 0.311
0.237TyrHis: 0.237 ± 0.13
1.105TyrIle: 1.105 ± 0.299
1.105TyrLys: 1.105 ± 0.312
2.605TyrLeu: 2.605 ± 0.442
0.947TyrMet: 0.947 ± 0.275
0.789TyrAsn: 0.789 ± 0.207
1.184TyrPro: 1.184 ± 0.375
1.737TyrGln: 1.737 ± 0.354
2.526TyrArg: 2.526 ± 0.513
1.737TyrSer: 1.737 ± 0.43
1.105TyrThr: 1.105 ± 0.234
1.974TyrVal: 1.974 ± 0.436
0.632TyrTrp: 0.632 ± 0.192
0.395TyrTyr: 0.395 ± 0.245
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 61 proteins (12668 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski