Amino acid dipepetide frequency for Xanthomonas phage OP2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
17.494AlaAla: 17.494 ± 1.298
0.86AlaCys: 0.86 ± 0.233
7.743AlaAsp: 7.743 ± 0.815
5.019AlaGlu: 5.019 ± 0.731
2.939AlaPhe: 2.939 ± 0.386
10.396AlaGly: 10.396 ± 1.166
2.796AlaHis: 2.796 ± 0.445
4.947AlaIle: 4.947 ± 0.565
3.8AlaLys: 3.8 ± 0.469
12.762AlaLeu: 12.762 ± 0.969
3.441AlaMet: 3.441 ± 0.486
4.517AlaAsn: 4.517 ± 0.753
6.309AlaPro: 6.309 ± 0.787
6.166AlaGln: 6.166 ± 0.721
7.313AlaArg: 7.313 ± 0.998
7.098AlaSer: 7.098 ± 0.904
8.102AlaThr: 8.102 ± 0.766
8.388AlaVal: 8.388 ± 0.753
1.864AlaTrp: 1.864 ± 0.363
2.868AlaTyr: 2.868 ± 0.407
0.072AlaXaa: 0.072 ± 0.074
Cys
0.789CysAla: 0.789 ± 0.208
0.072CysCys: 0.072 ± 0.078
0.502CysAsp: 0.502 ± 0.169
0.43CysGlu: 0.43 ± 0.185
0.143CysPhe: 0.143 ± 0.099
0.574CysGly: 0.574 ± 0.203
0.072CysHis: 0.072 ± 0.066
0.287CysIle: 0.287 ± 0.121
0.215CysLys: 0.215 ± 0.118
0.717CysLeu: 0.717 ± 0.223
0.287CysMet: 0.287 ± 0.173
0.215CysAsn: 0.215 ± 0.157
0.502CysPro: 0.502 ± 0.249
0.358CysGln: 0.358 ± 0.127
0.717CysArg: 0.717 ± 0.244
0.789CysSer: 0.789 ± 0.24
0.574CysThr: 0.574 ± 0.199
0.717CysVal: 0.717 ± 0.187
0.0CysTrp: 0.0 ± 0.0
0.287CysTyr: 0.287 ± 0.142
0.0CysXaa: 0.0 ± 0.0
Asp
8.102AspAla: 8.102 ± 0.779
0.717AspCys: 0.717 ± 0.241
3.441AspAsp: 3.441 ± 0.612
2.223AspGlu: 2.223 ± 0.373
2.294AspPhe: 2.294 ± 0.367
4.302AspGly: 4.302 ± 0.465
0.287AspHis: 0.287 ± 0.128
3.083AspIle: 3.083 ± 0.566
1.792AspLys: 1.792 ± 0.35
6.739AspLeu: 6.739 ± 0.806
1.075AspMet: 1.075 ± 0.272
2.223AspAsn: 2.223 ± 0.313
3.585AspPro: 3.585 ± 0.494
1.936AspGln: 1.936 ± 0.398
3.226AspArg: 3.226 ± 0.389
3.585AspSer: 3.585 ± 0.608
3.226AspThr: 3.226 ± 0.44
5.449AspVal: 5.449 ± 0.556
1.219AspTrp: 1.219 ± 0.323
2.151AspTyr: 2.151 ± 0.354
0.0AspXaa: 0.0 ± 0.0
Glu
5.807GluAla: 5.807 ± 0.725
0.358GluCys: 0.358 ± 0.175
2.724GluAsp: 2.724 ± 0.466
1.506GluGlu: 1.506 ± 0.286
1.219GluPhe: 1.219 ± 0.294
2.939GluGly: 2.939 ± 0.406
1.075GluHis: 1.075 ± 0.329
2.079GluIle: 2.079 ± 0.449
1.075GluLys: 1.075 ± 0.321
5.377GluLeu: 5.377 ± 0.606
1.075GluMet: 1.075 ± 0.268
0.717GluAsn: 0.717 ± 0.228
2.294GluPro: 2.294 ± 0.44
1.864GluGln: 1.864 ± 0.454
3.298GluArg: 3.298 ± 0.507
2.509GluSer: 2.509 ± 0.401
2.294GluThr: 2.294 ± 0.351
3.298GluVal: 3.298 ± 0.572
0.789GluTrp: 0.789 ± 0.227
1.577GluTyr: 1.577 ± 0.273
0.0GluXaa: 0.0 ± 0.0
Phe
3.728PheAla: 3.728 ± 0.466
0.502PheCys: 0.502 ± 0.181
2.939PheAsp: 2.939 ± 0.503
1.506PheGlu: 1.506 ± 0.299
0.86PhePhe: 0.86 ± 0.324
3.37PheGly: 3.37 ± 0.51
0.215PheHis: 0.215 ± 0.131
1.004PheIle: 1.004 ± 0.257
0.717PheLys: 0.717 ± 0.203
1.434PheLeu: 1.434 ± 0.326
0.645PheMet: 0.645 ± 0.212
1.147PheAsn: 1.147 ± 0.26
1.004PhePro: 1.004 ± 0.23
0.717PheGln: 0.717 ± 0.229
1.506PheArg: 1.506 ± 0.328
1.506PheSer: 1.506 ± 0.307
1.936PheThr: 1.936 ± 0.334
3.37PheVal: 3.37 ± 0.44
0.502PheTrp: 0.502 ± 0.193
0.502PheTyr: 0.502 ± 0.169
0.0PheXaa: 0.0 ± 0.0
Gly
8.532GlyAla: 8.532 ± 1.214
0.717GlyCys: 0.717 ± 0.215
3.8GlyAsp: 3.8 ± 0.507
3.37GlyGlu: 3.37 ± 0.602
3.298GlyPhe: 3.298 ± 0.507
7.528GlyGly: 7.528 ± 1.901
0.932GlyHis: 0.932 ± 0.288
4.158GlyIle: 4.158 ± 0.53
3.298GlyLys: 3.298 ± 0.462
6.739GlyLeu: 6.739 ± 0.901
1.792GlyMet: 1.792 ± 0.421
2.079GlyAsn: 2.079 ± 0.396
2.438GlyPro: 2.438 ± 0.35
3.298GlyGln: 3.298 ± 0.521
6.237GlyArg: 6.237 ± 0.57
4.087GlySer: 4.087 ± 0.87
5.807GlyThr: 5.807 ± 0.747
6.883GlyVal: 6.883 ± 0.727
0.932GlyTrp: 0.932 ± 0.262
2.796GlyTyr: 2.796 ± 0.447
0.0GlyXaa: 0.0 ± 0.0
His
1.219HisAla: 1.219 ± 0.288
0.215HisCys: 0.215 ± 0.111
0.932HisAsp: 0.932 ± 0.208
0.645HisGlu: 0.645 ± 0.197
0.287HisPhe: 0.287 ± 0.138
1.219HisGly: 1.219 ± 0.332
0.287HisHis: 0.287 ± 0.133
0.789HisIle: 0.789 ± 0.222
0.358HisLys: 0.358 ± 0.188
1.075HisLeu: 1.075 ± 0.276
0.645HisMet: 0.645 ± 0.224
0.932HisAsn: 0.932 ± 0.24
0.932HisPro: 0.932 ± 0.258
0.43HisGln: 0.43 ± 0.189
1.362HisArg: 1.362 ± 0.365
1.147HisSer: 1.147 ± 0.267
1.004HisThr: 1.004 ± 0.21
1.577HisVal: 1.577 ± 0.341
0.143HisTrp: 0.143 ± 0.118
0.502HisTyr: 0.502 ± 0.177
0.0HisXaa: 0.0 ± 0.0
Ile
5.234IleAla: 5.234 ± 0.623
0.287IleCys: 0.287 ± 0.135
3.8IleAsp: 3.8 ± 0.41
2.509IleGlu: 2.509 ± 0.311
0.86IlePhe: 0.86 ± 0.213
3.585IleGly: 3.585 ± 0.476
0.789IleHis: 0.789 ± 0.272
1.721IleIle: 1.721 ± 0.384
1.792IleLys: 1.792 ± 0.396
2.939IleLeu: 2.939 ± 0.449
0.932IleMet: 0.932 ± 0.259
1.721IleAsn: 1.721 ± 0.29
2.007IlePro: 2.007 ± 0.278
1.577IleGln: 1.577 ± 0.287
2.796IleArg: 2.796 ± 0.437
2.581IleSer: 2.581 ± 0.398
3.441IleThr: 3.441 ± 0.522
4.158IleVal: 4.158 ± 0.562
0.645IleTrp: 0.645 ± 0.202
1.577IleTyr: 1.577 ± 0.379
0.0IleXaa: 0.0 ± 0.0
Lys
3.656LysAla: 3.656 ± 0.491
0.358LysCys: 0.358 ± 0.174
1.362LysAsp: 1.362 ± 0.319
1.219LysGlu: 1.219 ± 0.242
0.789LysPhe: 0.789 ± 0.24
2.509LysGly: 2.509 ± 0.409
0.574LysHis: 0.574 ± 0.162
1.936LysIle: 1.936 ± 0.319
0.717LysLys: 0.717 ± 0.172
2.939LysLeu: 2.939 ± 0.462
0.789LysMet: 0.789 ± 0.218
0.789LysAsn: 0.789 ± 0.218
1.577LysPro: 1.577 ± 0.289
1.506LysGln: 1.506 ± 0.376
2.294LysArg: 2.294 ± 0.466
1.577LysSer: 1.577 ± 0.403
1.792LysThr: 1.792 ± 0.373
2.294LysVal: 2.294 ± 0.394
0.502LysTrp: 0.502 ± 0.179
0.86LysTyr: 0.86 ± 0.219
0.0LysXaa: 0.0 ± 0.0
Leu
10.683LeuAla: 10.683 ± 1.033
0.86LeuCys: 0.86 ± 0.236
5.951LeuAsp: 5.951 ± 0.79
4.445LeuGlu: 4.445 ± 0.616
2.796LeuPhe: 2.796 ± 0.428
5.664LeuGly: 5.664 ± 0.485
1.004LeuHis: 1.004 ± 0.295
3.155LeuIle: 3.155 ± 0.463
2.509LeuLys: 2.509 ± 0.414
6.166LeuLeu: 6.166 ± 0.716
2.294LeuMet: 2.294 ± 0.413
2.438LeuAsn: 2.438 ± 0.385
6.094LeuPro: 6.094 ± 0.741
4.087LeuGln: 4.087 ± 0.533
7.241LeuArg: 7.241 ± 0.789
7.241LeuSer: 7.241 ± 0.666
6.811LeuThr: 6.811 ± 0.723
4.66LeuVal: 4.66 ± 0.55
1.075LeuTrp: 1.075 ± 0.302
1.792LeuTyr: 1.792 ± 0.366
0.0LeuXaa: 0.0 ± 0.0
Met
3.513MetAla: 3.513 ± 0.594
0.287MetCys: 0.287 ± 0.13
1.362MetAsp: 1.362 ± 0.307
0.43MetGlu: 0.43 ± 0.238
0.574MetPhe: 0.574 ± 0.202
1.147MetGly: 1.147 ± 0.242
0.574MetHis: 0.574 ± 0.16
1.075MetIle: 1.075 ± 0.238
1.147MetLys: 1.147 ± 0.286
1.864MetLeu: 1.864 ± 0.428
0.574MetMet: 0.574 ± 0.183
0.932MetAsn: 0.932 ± 0.284
1.219MetPro: 1.219 ± 0.267
0.717MetGln: 0.717 ± 0.214
2.151MetArg: 2.151 ± 0.444
1.864MetSer: 1.864 ± 0.328
2.581MetThr: 2.581 ± 0.331
1.291MetVal: 1.291 ± 0.3
0.215MetTrp: 0.215 ± 0.111
0.287MetTyr: 0.287 ± 0.134
0.0MetXaa: 0.0 ± 0.0
Asn
4.947AsnAla: 4.947 ± 0.573
0.358AsnCys: 0.358 ± 0.132
2.007AsnAsp: 2.007 ± 0.369
1.147AsnGlu: 1.147 ± 0.248
0.789AsnPhe: 0.789 ± 0.289
3.083AsnGly: 3.083 ± 0.489
0.502AsnHis: 0.502 ± 0.203
1.649AsnIle: 1.649 ± 0.363
0.789AsnLys: 0.789 ± 0.29
2.438AsnLeu: 2.438 ± 0.419
0.502AsnMet: 0.502 ± 0.257
1.291AsnAsn: 1.291 ± 0.367
3.155AsnPro: 3.155 ± 0.472
0.717AsnGln: 0.717 ± 0.199
1.649AsnArg: 1.649 ± 0.3
1.506AsnSer: 1.506 ± 0.311
2.581AsnThr: 2.581 ± 0.536
2.653AsnVal: 2.653 ± 0.481
0.645AsnTrp: 0.645 ± 0.208
0.789AsnTyr: 0.789 ± 0.277
0.0AsnXaa: 0.0 ± 0.0
Pro
6.668ProAla: 6.668 ± 0.669
0.0ProCys: 0.0 ± 0.0
3.943ProAsp: 3.943 ± 0.595
3.155ProGlu: 3.155 ± 0.549
1.434ProPhe: 1.434 ± 0.345
5.09ProGly: 5.09 ± 0.821
1.147ProHis: 1.147 ± 0.38
2.581ProIle: 2.581 ± 0.374
1.434ProLys: 1.434 ± 0.337
3.728ProLeu: 3.728 ± 0.467
1.147ProMet: 1.147 ± 0.237
1.864ProAsn: 1.864 ± 0.291
2.366ProPro: 2.366 ± 0.492
2.939ProGln: 2.939 ± 0.346
3.155ProArg: 3.155 ± 0.547
3.943ProSer: 3.943 ± 0.639
4.373ProThr: 4.373 ± 0.679
4.66ProVal: 4.66 ± 0.672
0.645ProTrp: 0.645 ± 0.201
1.792ProTyr: 1.792 ± 0.265
0.0ProXaa: 0.0 ± 0.0
Gln
5.377GlnAla: 5.377 ± 0.624
0.358GlnCys: 0.358 ± 0.136
2.151GlnAsp: 2.151 ± 0.42
1.147GlnGlu: 1.147 ± 0.333
1.649GlnPhe: 1.649 ± 0.293
2.796GlnGly: 2.796 ± 0.343
0.358GlnHis: 0.358 ± 0.136
2.438GlnIle: 2.438 ± 0.418
1.004GlnLys: 1.004 ± 0.239
5.162GlnLeu: 5.162 ± 0.652
0.502GlnMet: 0.502 ± 0.192
1.004GlnAsn: 1.004 ± 0.256
2.581GlnPro: 2.581 ± 0.369
2.294GlnGln: 2.294 ± 0.554
3.513GlnArg: 3.513 ± 0.512
2.939GlnSer: 2.939 ± 0.375
3.513GlnThr: 3.513 ± 0.635
2.581GlnVal: 2.581 ± 0.514
0.717GlnTrp: 0.717 ± 0.255
1.075GlnTyr: 1.075 ± 0.318
0.0GlnXaa: 0.0 ± 0.0
Arg
8.603ArgAla: 8.603 ± 1.091
0.645ArgCys: 0.645 ± 0.262
3.441ArgAsp: 3.441 ± 0.534
3.943ArgGlu: 3.943 ± 0.675
2.223ArgPhe: 2.223 ± 0.543
3.585ArgGly: 3.585 ± 0.436
1.577ArgHis: 1.577 ± 0.353
2.939ArgIle: 2.939 ± 0.417
2.223ArgLys: 2.223 ± 0.507
6.022ArgLeu: 6.022 ± 0.561
2.581ArgMet: 2.581 ± 0.347
2.366ArgAsn: 2.366 ± 0.392
3.011ArgPro: 3.011 ± 0.499
3.298ArgGln: 3.298 ± 0.514
4.087ArgArg: 4.087 ± 0.547
3.585ArgSer: 3.585 ± 0.426
4.66ArgThr: 4.66 ± 0.581
4.158ArgVal: 4.158 ± 0.475
1.219ArgTrp: 1.219 ± 0.298
2.509ArgTyr: 2.509 ± 0.367
0.0ArgXaa: 0.0 ± 0.0
Ser
7.6SerAla: 7.6 ± 0.898
0.574SerCys: 0.574 ± 0.199
3.37SerAsp: 3.37 ± 0.547
2.509SerGlu: 2.509 ± 0.427
2.007SerPhe: 2.007 ± 0.309
6.453SerGly: 6.453 ± 0.789
1.004SerHis: 1.004 ± 0.257
2.724SerIle: 2.724 ± 0.464
1.936SerLys: 1.936 ± 0.271
4.804SerLeu: 4.804 ± 0.613
1.291SerMet: 1.291 ± 0.275
1.649SerAsn: 1.649 ± 0.312
4.158SerPro: 4.158 ± 0.561
2.079SerGln: 2.079 ± 0.412
3.298SerArg: 3.298 ± 0.338
4.66SerSer: 4.66 ± 0.532
5.664SerThr: 5.664 ± 0.671
4.875SerVal: 4.875 ± 0.697
0.717SerTrp: 0.717 ± 0.281
1.362SerTyr: 1.362 ± 0.302
0.0SerXaa: 0.0 ± 0.0
Thr
8.317ThrAla: 8.317 ± 0.869
0.287ThrCys: 0.287 ± 0.174
4.015ThrAsp: 4.015 ± 0.641
2.223ThrGlu: 2.223 ± 0.531
2.151ThrPhe: 2.151 ± 0.342
5.807ThrGly: 5.807 ± 0.715
0.932ThrHis: 0.932 ± 0.23
3.226ThrIle: 3.226 ± 0.358
1.792ThrLys: 1.792 ± 0.405
6.309ThrLeu: 6.309 ± 0.746
1.147ThrMet: 1.147 ± 0.248
2.581ThrAsn: 2.581 ± 0.471
5.879ThrPro: 5.879 ± 0.606
3.37ThrGln: 3.37 ± 0.439
3.441ThrArg: 3.441 ± 0.467
4.373ThrSer: 4.373 ± 0.603
5.449ThrThr: 5.449 ± 0.805
5.807ThrVal: 5.807 ± 0.734
1.219ThrTrp: 1.219 ± 0.228
3.011ThrTyr: 3.011 ± 0.581
0.072ThrXaa: 0.072 ± 0.078
Val
9.751ValAla: 9.751 ± 1.143
0.287ValCys: 0.287 ± 0.131
4.015ValAsp: 4.015 ± 0.431
5.019ValGlu: 5.019 ± 0.657
1.792ValPhe: 1.792 ± 0.39
5.592ValGly: 5.592 ± 0.622
0.717ValHis: 0.717 ± 0.203
3.585ValIle: 3.585 ± 0.389
2.223ValLys: 2.223 ± 0.353
6.166ValLeu: 6.166 ± 0.679
2.366ValMet: 2.366 ± 0.379
3.298ValAsn: 3.298 ± 0.552
4.23ValPro: 4.23 ± 0.53
2.724ValGln: 2.724 ± 0.481
5.377ValArg: 5.377 ± 0.548
4.588ValSer: 4.588 ± 0.505
4.875ValThr: 4.875 ± 0.673
5.162ValVal: 5.162 ± 0.577
1.291ValTrp: 1.291 ± 0.282
2.223ValTyr: 2.223 ± 0.415
0.0ValXaa: 0.0 ± 0.0
Trp
1.792TrpAla: 1.792 ± 0.353
0.143TrpCys: 0.143 ± 0.101
0.932TrpAsp: 0.932 ± 0.226
0.932TrpGlu: 0.932 ± 0.251
0.287TrpPhe: 0.287 ± 0.141
0.43TrpGly: 0.43 ± 0.149
0.287TrpHis: 0.287 ± 0.148
0.358TrpIle: 0.358 ± 0.19
0.43TrpLys: 0.43 ± 0.162
1.506TrpLeu: 1.506 ± 0.293
0.358TrpMet: 0.358 ± 0.156
0.287TrpAsn: 0.287 ± 0.153
0.717TrpPro: 0.717 ± 0.216
1.075TrpGln: 1.075 ± 0.319
1.219TrpArg: 1.219 ± 0.316
1.075TrpSer: 1.075 ± 0.258
1.291TrpThr: 1.291 ± 0.295
1.004TrpVal: 1.004 ± 0.257
0.43TrpTrp: 0.43 ± 0.168
0.86TrpTyr: 0.86 ± 0.237
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.083TyrAla: 3.083 ± 0.419
0.358TyrCys: 0.358 ± 0.154
2.223TyrAsp: 2.223 ± 0.42
0.502TyrGlu: 0.502 ± 0.192
0.717TyrPhe: 0.717 ± 0.21
2.653TyrGly: 2.653 ± 0.413
0.574TyrHis: 0.574 ± 0.205
1.219TyrIle: 1.219 ± 0.277
0.789TyrLys: 0.789 ± 0.203
2.079TyrLeu: 2.079 ± 0.35
0.287TyrMet: 0.287 ± 0.168
1.147TyrAsn: 1.147 ± 0.342
2.007TyrPro: 2.007 ± 0.386
2.007TyrGln: 2.007 ± 0.37
2.724TyrArg: 2.724 ± 0.479
2.079TyrSer: 2.079 ± 0.359
1.434TyrThr: 1.434 ± 0.386
2.294TyrVal: 2.294 ± 0.476
0.645TyrTrp: 0.645 ± 0.223
0.143TyrTyr: 0.143 ± 0.095
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.072XaaAsn: 0.072 ± 0.078
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.072XaaArg: 0.072 ± 0.074
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 62 proteins (13949 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski