Amino acid dipepetide frequency for Phalacrocorax carbo (Great cormorant) (Pelecanus carbo)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.411AlaAla: 5.411 ± 0.051	1.313AlaCys: 1.313 ± 0.022	3.02AlaAsp: 3.02 ± 0.033	4.537AlaGlu: 4.537 ± 0.043	2.607AlaPhe: 2.607 ± 0.03	3.735AlaGly: 3.735 ± 0.041	1.344AlaHis: 1.344 ± 0.019	3.12AlaIle: 3.12 ± 0.032	3.734AlaLys: 3.734 ± 0.035	6.288AlaLeu: 6.288 ± 0.051	1.504AlaMet: 1.504 ± 0.021	2.286AlaAsn: 2.286 ± 0.024	2.75AlaPro: 2.75 ± 0.033	2.682AlaGln: 2.682 ± 0.032	2.845AlaArg: 2.845 ± 0.03	5.156AlaSer: 5.156 ± 0.043	3.318AlaThr: 3.318 ± 0.033	4.807AlaVal: 4.807 ± 0.041	0.683AlaTrp: 0.683 ± 0.017	1.642AlaTyr: 1.642 ± 0.021	0.001AlaXaa: 0.001 ± 0.001
Cys	1.161CysAla: 1.161 ± 0.02	0.641CysCys: 0.641 ± 0.015	1.057CysAsp: 1.057 ± 0.02	1.309CysGlu: 1.309 ± 0.03	0.947CysPhe: 0.947 ± 0.017	1.425CysGly: 1.425 ± 0.028	0.653CysHis: 0.653 ± 0.016	1.166CysIle: 1.166 ± 0.021	1.359CysLys: 1.359 ± 0.022	2.169CysLeu: 2.169 ± 0.025	0.464CysMet: 0.464 ± 0.011	0.959CysAsn: 0.959 ± 0.017	1.19CysPro: 1.19 ± 0.027	1.063CysGln: 1.063 ± 0.02	1.211CysArg: 1.211 ± 0.02	2.036CysSer: 2.036 ± 0.03	1.213CysThr: 1.213 ± 0.022	1.329CysVal: 1.329 ± 0.021	0.292CysTrp: 0.292 ± 0.009	0.689CysTyr: 0.689 ± 0.016	0.0CysXaa: 0.0 ± 0.0
Asp	2.878AspAla: 2.878 ± 0.031	1.103AspCys: 1.103 ± 0.02	2.951AspAsp: 2.951 ± 0.036	3.701AspGlu: 3.701 ± 0.046	2.287AspPhe: 2.287 ± 0.024	3.229AspGly: 3.229 ± 0.039	1.203AspHis: 1.203 ± 0.018	3.058AspIle: 3.058 ± 0.03	2.902AspLys: 2.902 ± 0.032	5.086AspLeu: 5.086 ± 0.042	1.163AspMet: 1.163 ± 0.017	2.014AspAsn: 2.014 ± 0.025	2.602AspPro: 2.602 ± 0.028	1.907AspGln: 1.907 ± 0.023	2.392AspArg: 2.392 ± 0.029	4.202AspSer: 4.202 ± 0.036	2.555AspThr: 2.555 ± 0.026	3.254AspVal: 3.254 ± 0.034	0.645AspTrp: 0.645 ± 0.013	1.695AspTyr: 1.695 ± 0.024	0.0AspXaa: 0.0 ± 0.0
Glu	4.611GluAla: 4.611 ± 0.047	1.336GluCys: 1.336 ± 0.033	4.621GluAsp: 4.621 ± 0.044	7.923GluGlu: 7.923 ± 0.089	2.313GluPhe: 2.313 ± 0.027	3.828GluGly: 3.828 ± 0.04	1.577GluHis: 1.577 ± 0.024	3.662GluIle: 3.662 ± 0.03	5.848GluLys: 5.848 ± 0.065	6.325GluLeu: 6.325 ± 0.068	1.818GluMet: 1.818 ± 0.024	3.616GluAsn: 3.616 ± 0.032	2.513GluPro: 2.513 ± 0.025	3.243GluGln: 3.243 ± 0.038	3.855GluArg: 3.855 ± 0.053	4.546GluSer: 4.546 ± 0.036	3.62GluThr: 3.62 ± 0.039	4.34GluVal: 4.34 ± 0.034	0.733GluTrp: 0.733 ± 0.015	1.884GluTyr: 1.884 ± 0.023	0.002GluXaa: 0.002 ± 0.001
Phe	2.162PheAla: 2.162 ± 0.026	1.02PheCys: 1.02 ± 0.018	1.863PheAsp: 1.863 ± 0.025	2.215PheGlu: 2.215 ± 0.025	1.839PhePhe: 1.839 ± 0.027	2.298PheGly: 2.298 ± 0.027	1.126PheHis: 1.126 ± 0.017	2.169PheIle: 2.169 ± 0.028	2.11PheLys: 2.11 ± 0.023	4.281PheLeu: 4.281 ± 0.044	0.83PheMet: 0.83 ± 0.016	1.56PheAsn: 1.56 ± 0.021	1.973PhePro: 1.973 ± 0.028	1.833PheGln: 1.833 ± 0.022	1.888PheArg: 1.888 ± 0.024	3.524PheSer: 3.524 ± 0.032	2.285PheThr: 2.285 ± 0.029	2.417PheVal: 2.417 ± 0.03	0.526PheTrp: 0.526 ± 0.012	1.379PheTyr: 1.379 ± 0.018	0.0PheXaa: 0.0 ± 0.0
Gly	3.363GlyAla: 3.363 ± 0.037	1.203GlyCys: 1.203 ± 0.019	2.925GlyAsp: 2.925 ± 0.036	3.703GlyGlu: 3.703 ± 0.044	2.515GlyPhe: 2.515 ± 0.034	3.711GlyGly: 3.711 ± 0.055	1.486GlyHis: 1.486 ± 0.022	3.171GlyIle: 3.171 ± 0.036	4.001GlyLys: 4.001 ± 0.037	5.085GlyLeu: 5.085 ± 0.05	1.354GlyMet: 1.354 ± 0.024	2.637GlyAsn: 2.637 ± 0.033	2.65GlyPro: 2.65 ± 0.072	2.458GlyGln: 2.458 ± 0.029	3.007GlyArg: 3.007 ± 0.038	4.926GlySer: 4.926 ± 0.044	3.348GlyThr: 3.348 ± 0.038	3.43GlyVal: 3.43 ± 0.032	0.737GlyTrp: 0.737 ± 0.017	1.897GlyTyr: 1.897 ± 0.026	0.002GlyXaa: 0.002 ± 0.001
His	1.318HisAla: 1.318 ± 0.021	0.733HisCys: 0.733 ± 0.014	0.948HisAsp: 0.948 ± 0.016	1.397HisGlu: 1.397 ± 0.021	1.109HisPhe: 1.109 ± 0.017	1.478HisGly: 1.478 ± 0.023	0.874HisHis: 0.874 ± 0.02	1.393HisIle: 1.393 ± 0.021	1.432HisLys: 1.432 ± 0.02	2.835HisLeu: 2.835 ± 0.03	0.58HisMet: 0.58 ± 0.012	1.006HisAsn: 1.006 ± 0.017	1.467HisPro: 1.467 ± 0.02	1.206HisGln: 1.206 ± 0.02	1.428HisArg: 1.428 ± 0.024	2.225HisSer: 2.225 ± 0.03	1.323HisThr: 1.323 ± 0.022	1.529HisVal: 1.529 ± 0.022	0.346HisTrp: 0.346 ± 0.011	0.858HisTyr: 0.858 ± 0.015	0.001HisXaa: 0.001 ± 0.0
Ile	3.085IleAla: 3.085 ± 0.032	1.244IleCys: 1.244 ± 0.018	2.417IleAsp: 2.417 ± 0.029	3.005IleGlu: 3.005 ± 0.033	2.232IlePhe: 2.232 ± 0.027	2.572IleGly: 2.572 ± 0.033	1.441IleHis: 1.441 ± 0.021	2.897IleIle: 2.897 ± 0.037	3.186IleLys: 3.186 ± 0.032	5.172IleLeu: 5.172 ± 0.047	1.128IleMet: 1.128 ± 0.018	2.248IleAsn: 2.248 ± 0.025	2.929IlePro: 2.929 ± 0.027	2.546IleGln: 2.546 ± 0.028	2.535IleArg: 2.535 ± 0.023	4.235IleSer: 4.235 ± 0.037	2.989IleThr: 2.989 ± 0.033	3.001IleVal: 3.001 ± 0.032	0.592IleTrp: 0.592 ± 0.011	1.653IleTyr: 1.653 ± 0.025	0.001IleXaa: 0.001 ± 0.0
Lys	4.173LysAla: 4.173 ± 0.038	1.277LysCys: 1.277 ± 0.022	3.574LysAsp: 3.574 ± 0.038	5.827LysGlu: 5.827 ± 0.065	1.975LysPhe: 1.975 ± 0.024	3.484LysGly: 3.484 ± 0.046	1.632LysHis: 1.632 ± 0.026	3.354LysIle: 3.354 ± 0.034	5.574LysLys: 5.574 ± 0.065	5.856LysLeu: 5.856 ± 0.045	1.608LysMet: 1.608 ± 0.021	2.9LysAsn: 2.9 ± 0.03	3.124LysPro: 3.124 ± 0.039	3.071LysGln: 3.071 ± 0.034	3.593LysArg: 3.593 ± 0.043	4.428LysSer: 4.428 ± 0.04	3.52LysThr: 3.52 ± 0.04	3.812LysVal: 3.812 ± 0.031	0.705LysTrp: 0.705 ± 0.013	1.946LysTyr: 1.946 ± 0.026	0.001LysXaa: 0.001 ± 0.001
Leu	6.106LeuAla: 6.106 ± 0.05	2.219LeuCys: 2.219 ± 0.028	4.836LeuAsp: 4.836 ± 0.04	6.95LeuGlu: 6.95 ± 0.066	3.645LeuPhe: 3.645 ± 0.035	5.09LeuGly: 5.09 ± 0.046	2.68LeuHis: 2.68 ± 0.032	4.395LeuIle: 4.395 ± 0.047	6.593LeuLys: 6.593 ± 0.053	9.994LeuLeu: 9.994 ± 0.092	2.097LeuMet: 2.097 ± 0.026	4.034LeuAsn: 4.034 ± 0.036	5.277LeuPro: 5.277 ± 0.054	5.674LeuGln: 5.674 ± 0.058	5.014LeuArg: 5.014 ± 0.044	7.797LeuSer: 7.797 ± 0.049	5.086LeuThr: 5.086 ± 0.038	5.433LeuVal: 5.433 ± 0.052	1.066LeuTrp: 1.066 ± 0.022	2.817LeuTyr: 2.817 ± 0.027	0.003LeuXaa: 0.003 ± 0.001
Met	1.616MetAla: 1.616 ± 0.023	0.452MetCys: 0.452 ± 0.011	1.313MetAsp: 1.313 ± 0.018	1.89MetGlu: 1.89 ± 0.025	0.847MetPhe: 0.847 ± 0.015	1.276MetGly: 1.276 ± 0.021	0.534MetHis: 0.534 ± 0.012	1.017MetIle: 1.017 ± 0.018	1.664MetLys: 1.664 ± 0.022	2.106MetLeu: 2.106 ± 0.021	0.624MetMet: 0.624 ± 0.013	1.043MetAsn: 1.043 ± 0.016	1.05MetPro: 1.05 ± 0.016	1.045MetGln: 1.045 ± 0.016	1.05MetArg: 1.05 ± 0.017	1.556MetSer: 1.556 ± 0.02	1.178MetThr: 1.178 ± 0.017	1.476MetVal: 1.476 ± 0.023	0.254MetTrp: 0.254 ± 0.008	0.683MetTyr: 0.683 ± 0.014	0.001MetXaa: 0.001 ± 0.0
Asn	2.416AsnAla: 2.416 ± 0.025	0.99AsnCys: 0.99 ± 0.019	1.785AsnAsp: 1.785 ± 0.025	2.738AsnGlu: 2.738 ± 0.03	1.678AsnPhe: 1.678 ± 0.02	2.83AsnGly: 2.83 ± 0.037	1.036AsnHis: 1.036 ± 0.016	2.633AsnIle: 2.633 ± 0.029	2.702AsnLys: 2.702 ± 0.029	4.178AsnLeu: 4.178 ± 0.042	1.013AsnMet: 1.013 ± 0.018	1.945AsnAsn: 1.945 ± 0.027	2.304AsnPro: 2.304 ± 0.029	1.795AsnGln: 1.795 ± 0.021	2.038AsnArg: 2.038 ± 0.022	3.578AsnSer: 3.578 ± 0.038	2.355AsnThr: 2.355 ± 0.027	2.553AsnVal: 2.553 ± 0.028	0.516AsnTrp: 0.516 ± 0.012	1.358AsnTyr: 1.358 ± 0.02	0.001AsnXaa: 0.001 ± 0.001
Pro	3.492ProAla: 3.492 ± 0.04	1.021ProCys: 1.021 ± 0.023	2.62ProAsp: 2.62 ± 0.03	3.829ProGlu: 3.829 ± 0.04	1.928ProPhe: 1.928 ± 0.027	3.533ProGly: 3.533 ± 0.104	1.183ProHis: 1.183 ± 0.02	2.01ProIle: 2.01 ± 0.027	2.772ProLys: 2.772 ± 0.035	4.555ProLeu: 4.555 ± 0.041	0.943ProMet: 0.943 ± 0.018	1.934ProAsn: 1.934 ± 0.025	4.052ProPro: 4.052 ± 0.073	2.274ProGln: 2.274 ± 0.035	2.358ProArg: 2.358 ± 0.029	4.831ProSer: 4.831 ± 0.055	2.645ProThr: 2.645 ± 0.03	3.73ProVal: 3.73 ± 0.032	0.563ProTrp: 0.563 ± 0.013	1.468ProTyr: 1.468 ± 0.02	0.002ProXaa: 0.002 ± 0.001
Gln	3.025GlnAla: 3.025 ± 0.033	0.96GlnCys: 0.96 ± 0.019	2.252GlnAsp: 2.252 ± 0.027	3.747GlnGlu: 3.747 ± 0.049	1.501GlnPhe: 1.501 ± 0.022	2.427GlnGly: 2.427 ± 0.035	1.297GlnHis: 1.297 ± 0.021	2.289GlnIle: 2.289 ± 0.026	3.286GlnLys: 3.286 ± 0.037	4.612GlnLeu: 4.612 ± 0.05	1.134GlnMet: 1.134 ± 0.016	2.114GlnAsn: 2.114 ± 0.024	2.309GlnPro: 2.309 ± 0.034	3.033GlnGln: 3.033 ± 0.059	2.618GlnArg: 2.618 ± 0.028	3.238GlnSer: 3.238 ± 0.04	2.402GlnThr: 2.402 ± 0.028	2.744GlnVal: 2.744 ± 0.033	0.529GlnTrp: 0.529 ± 0.013	1.307GlnTyr: 1.307 ± 0.022	0.001GlnXaa: 0.001 ± 0.001
Arg	2.909ArgAla: 2.909 ± 0.031	1.096ArgCys: 1.096 ± 0.022	2.522ArgAsp: 2.522 ± 0.034	3.694ArgGlu: 3.694 ± 0.046	1.866ArgPhe: 1.866 ± 0.025	2.714ArgGly: 2.714 ± 0.038	1.4ArgHis: 1.4 ± 0.02	2.623ArgIle: 2.623 ± 0.029	3.975ArgLys: 3.975 ± 0.045	4.706ArgLeu: 4.706 ± 0.043	1.194ArgMet: 1.194 ± 0.021	2.292ArgAsn: 2.292 ± 0.026	2.311ArgPro: 2.311 ± 0.029	2.469ArgGln: 2.469 ± 0.03	3.532ArgArg: 3.532 ± 0.037	3.887ArgSer: 3.887 ± 0.052	2.669ArgThr: 2.669 ± 0.029	2.813ArgVal: 2.813 ± 0.028	0.625ArgTrp: 0.625 ± 0.013	1.588ArgTyr: 1.588 ± 0.019	0.001ArgXaa: 0.001 ± 0.001
Ser	5.07SerAla: 5.07 ± 0.042	1.863SerCys: 1.863 ± 0.029	4.068SerAsp: 4.068 ± 0.04	5.265SerGlu: 5.265 ± 0.05	3.193SerPhe: 3.193 ± 0.032	4.905SerGly: 4.905 ± 0.049	2.079SerHis: 2.079 ± 0.026	3.704SerIle: 3.704 ± 0.034	4.673SerLys: 4.673 ± 0.041	7.968SerLeu: 7.968 ± 0.055	1.667SerMet: 1.667 ± 0.021	3.207SerAsn: 3.207 ± 0.036	4.957SerPro: 4.957 ± 0.062	3.655SerGln: 3.655 ± 0.036	3.971SerArg: 3.971 ± 0.05	9.179SerSer: 9.179 ± 0.104	4.598SerThr: 4.598 ± 0.043	5.17SerVal: 5.17 ± 0.037	0.972SerTrp: 0.972 ± 0.018	2.288SerTyr: 2.288 ± 0.024	0.001SerXaa: 0.001 ± 0.001
Thr	3.799ThrAla: 3.799 ± 0.032	1.296ThrCys: 1.296 ± 0.026	2.795ThrAsp: 2.795 ± 0.03	3.857ThrGlu: 3.857 ± 0.033	2.222ThrPhe: 2.222 ± 0.027	3.435ThrGly: 3.435 ± 0.035	1.212ThrHis: 1.212 ± 0.022	2.68ThrIle: 2.68 ± 0.029	2.992ThrLys: 2.992 ± 0.034	5.177ThrLeu: 5.177 ± 0.042	1.135ThrMet: 1.135 ± 0.019	2.01ThrAsn: 2.01 ± 0.025	3.114ThrPro: 3.114 ± 0.041	2.137ThrGln: 2.137 ± 0.028	2.3ThrArg: 2.3 ± 0.023	4.747ThrSer: 4.747 ± 0.051	3.062ThrThr: 3.062 ± 0.042	4.167ThrVal: 4.167 ± 0.042	0.667ThrTrp: 0.667 ± 0.014	1.601ThrTyr: 1.601 ± 0.023	0.002ThrXaa: 0.002 ± 0.001
Val	3.957ValAla: 3.957 ± 0.038	1.526ValCys: 1.526 ± 0.024	3.085ValAsp: 3.085 ± 0.028	3.984ValGlu: 3.984 ± 0.04	2.702ValPhe: 2.702 ± 0.031	3.236ValGly: 3.236 ± 0.035	1.596ValHis: 1.596 ± 0.02	3.387ValIle: 3.387 ± 0.037	3.943ValLys: 3.943 ± 0.038	6.241ValLeu: 6.241 ± 0.052	1.411ValMet: 1.411 ± 0.02	2.677ValAsn: 2.677 ± 0.028	3.354ValPro: 3.354 ± 0.033	2.856ValGln: 2.856 ± 0.031	2.893ValArg: 2.893 ± 0.03	5.044ValSer: 5.044 ± 0.04	3.906ValThr: 3.906 ± 0.036	4.175ValVal: 4.175 ± 0.04	0.724ValTrp: 0.724 ± 0.015	1.9ValTyr: 1.9 ± 0.024	0.001ValXaa: 0.001 ± 0.0
Trp	0.649TrpAla: 0.649 ± 0.014	0.239TrpCys: 0.239 ± 0.008	0.674TrpAsp: 0.674 ± 0.016	0.787TrpGlu: 0.787 ± 0.016	0.462TrpPhe: 0.462 ± 0.011	0.634TrpGly: 0.634 ± 0.019	0.313TrpHis: 0.313 ± 0.01	0.66TrpIle: 0.66 ± 0.014	0.915TrpLys: 0.915 ± 0.015	1.16TrpLeu: 1.16 ± 0.021	0.299TrpMet: 0.299 ± 0.009	0.618TrpAsn: 0.618 ± 0.014	0.43TrpPro: 0.43 ± 0.012	0.544TrpGln: 0.544 ± 0.013	0.638TrpArg: 0.638 ± 0.016	0.863TrpSer: 0.863 ± 0.02	0.66TrpThr: 0.66 ± 0.016	0.65TrpVal: 0.65 ± 0.014	0.195TrpTrp: 0.195 ± 0.009	0.376TrpTyr: 0.376 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	1.579TyrAla: 1.579 ± 0.02	0.798TyrCys: 0.798 ± 0.014	1.499TyrAsp: 1.499 ± 0.024	1.854TyrGlu: 1.854 ± 0.023	1.428TyrPhe: 1.428 ± 0.022	1.766TyrGly: 1.766 ± 0.025	0.817TyrHis: 0.817 ± 0.014	1.723TyrIle: 1.723 ± 0.024	1.777TyrLys: 1.777 ± 0.025	3.009TyrLeu: 3.009 ± 0.027	0.708TyrMet: 0.708 ± 0.015	1.342TyrAsn: 1.342 ± 0.019	1.388TyrPro: 1.388 ± 0.021	1.334TyrGln: 1.334 ± 0.019	1.72TyrArg: 1.72 ± 0.025	2.453TyrSer: 2.453 ± 0.029	1.669TyrThr: 1.669 ± 0.02	1.768TyrVal: 1.768 ± 0.024	0.397TyrTrp: 0.397 ± 0.012	1.141TyrTyr: 1.141 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.002XaaAla: 0.002 ± 0.001	0.001XaaCys: 0.001 ± 0.0	0.001XaaAsp: 0.001 ± 0.0	0.001XaaGlu: 0.001 ± 0.0	0.002XaaPhe: 0.002 ± 0.001	0.0XaaGly: 0.0 ± 0.0	0.001XaaHis: 0.001 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.001XaaLys: 0.001 ± 0.001	0.002XaaLeu: 0.002 ± 0.001	0.001XaaMet: 0.001 ± 0.0	0.001XaaAsn: 0.001 ± 0.001	0.002XaaPro: 0.002 ± 0.001	0.001XaaGln: 0.001 ± 0.0	0.002XaaArg: 0.002 ± 0.001	0.003XaaSer: 0.003 ± 0.001	0.001XaaThr: 0.001 ± 0.001	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.001XaaTyr: 0.001 ± 0.0	0.11XaaXaa: 0.11 ± 0.013

Statistics based on 8990 proteins (3797346 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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