Amino acid dipepetide frequency for Acinetobacter sp. TGL-Y2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
7.071AlaAla: 7.071 ± 0.215
0.864AlaCys: 0.864 ± 0.033
4.526AlaAsp: 4.526 ± 0.119
5.538AlaGlu: 5.538 ± 0.118
3.326AlaPhe: 3.326 ± 0.068
5.702AlaGly: 5.702 ± 0.126
1.837AlaHis: 1.837 ± 0.048
5.902AlaIle: 5.902 ± 0.091
5.226AlaLys: 5.226 ± 0.089
9.382AlaLeu: 9.382 ± 0.145
2.343AlaMet: 2.343 ± 0.055
3.421AlaAsn: 3.421 ± 0.088
2.769AlaPro: 2.769 ± 0.058
4.546AlaGln: 4.546 ± 0.079
3.33AlaArg: 3.33 ± 0.065
4.963AlaSer: 4.963 ± 0.086
4.467AlaThr: 4.467 ± 0.103
5.846AlaVal: 5.846 ± 0.107
1.005AlaTrp: 1.005 ± 0.034
2.537AlaTyr: 2.537 ± 0.052
0.0AlaXaa: 0.0 ± 0.0
Cys
0.702CysAla: 0.702 ± 0.028
0.151CysCys: 0.151 ± 0.012
0.466CysAsp: 0.466 ± 0.022
0.522CysGlu: 0.522 ± 0.024
0.489CysPhe: 0.489 ± 0.023
0.717CysGly: 0.717 ± 0.029
0.257CysHis: 0.257 ± 0.013
0.677CysIle: 0.677 ± 0.028
0.409CysLys: 0.409 ± 0.021
0.999CysLeu: 0.999 ± 0.037
0.262CysMet: 0.262 ± 0.016
0.328CysAsn: 0.328 ± 0.018
0.418CysPro: 0.418 ± 0.024
0.393CysGln: 0.393 ± 0.021
0.452CysArg: 0.452 ± 0.024
0.654CysSer: 0.654 ± 0.027
0.465CysThr: 0.465 ± 0.025
0.651CysVal: 0.651 ± 0.021
0.092CysTrp: 0.092 ± 0.011
0.295CysTyr: 0.295 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
4.914AspAla: 4.914 ± 0.121
0.441AspCys: 0.441 ± 0.023
2.708AspAsp: 2.708 ± 0.062
3.464AspGlu: 3.464 ± 0.076
2.497AspPhe: 2.497 ± 0.058
3.377AspGly: 3.377 ± 0.136
1.367AspHis: 1.367 ± 0.039
3.756AspIle: 3.756 ± 0.059
2.67AspLys: 2.67 ± 0.059
5.867AspLeu: 5.867 ± 0.088
1.213AspMet: 1.213 ± 0.036
1.887AspAsn: 1.887 ± 0.059
2.116AspPro: 2.116 ± 0.056
3.12AspGln: 3.12 ± 0.075
2.386AspArg: 2.386 ± 0.06
3.131AspSer: 3.131 ± 0.136
2.668AspThr: 2.668 ± 0.073
3.737AspVal: 3.737 ± 0.067
0.798AspTrp: 0.798 ± 0.033
1.988AspTyr: 1.988 ± 0.044
0.0AspXaa: 0.0 ± 0.0
Glu
4.87GluAla: 4.87 ± 0.144
0.428GluCys: 0.428 ± 0.025
2.763GluAsp: 2.763 ± 0.063
3.012GluGlu: 3.012 ± 0.085
2.407GluPhe: 2.407 ± 0.057
3.08GluGly: 3.08 ± 0.065
1.624GluHis: 1.624 ± 0.049
4.455GluIle: 4.455 ± 0.068
4.126GluLys: 4.126 ± 0.083
6.147GluLeu: 6.147 ± 0.099
1.564GluMet: 1.564 ± 0.044
3.03GluAsn: 3.03 ± 0.056
1.698GluPro: 1.698 ± 0.052
3.874GluGln: 3.874 ± 0.087
2.83GluArg: 2.83 ± 0.063
3.225GluSer: 3.225 ± 0.062
2.99GluThr: 2.99 ± 0.059
3.75GluVal: 3.75 ± 0.062
0.747GluTrp: 0.747 ± 0.029
1.947GluTyr: 1.947 ± 0.054
0.0GluXaa: 0.0 ± 0.0
Phe
3.546PheAla: 3.546 ± 0.066
0.475PheCys: 0.475 ± 0.024
2.73PheAsp: 2.73 ± 0.049
2.798PheGlu: 2.798 ± 0.06
1.97PhePhe: 1.97 ± 0.053
3.045PheGly: 3.045 ± 0.069
0.903PheHis: 0.903 ± 0.03
3.113PheIle: 3.113 ± 0.066
2.767PheLys: 2.767 ± 0.057
3.762PheLeu: 3.762 ± 0.076
1.079PheMet: 1.079 ± 0.036
2.356PheAsn: 2.356 ± 0.056
1.458PhePro: 1.458 ± 0.049
1.629PheGln: 1.629 ± 0.046
1.451PheArg: 1.451 ± 0.035
3.092PheSer: 3.092 ± 0.066
2.091PheThr: 2.091 ± 0.044
2.637PheVal: 2.637 ± 0.055
0.559PheTrp: 0.559 ± 0.023
1.543PheTyr: 1.543 ± 0.043
0.0PheXaa: 0.0 ± 0.0
Gly
4.864GlyAla: 4.864 ± 0.122
0.782GlyCys: 0.782 ± 0.031
3.009GlyAsp: 3.009 ± 0.075
3.626GlyGlu: 3.626 ± 0.077
3.14GlyPhe: 3.14 ± 0.073
4.485GlyGly: 4.485 ± 0.109
1.509GlyHis: 1.509 ± 0.045
4.646GlyIle: 4.646 ± 0.077
3.789GlyLys: 3.789 ± 0.146
7.002GlyLeu: 7.002 ± 0.116
1.747GlyMet: 1.747 ± 0.048
2.641GlyAsn: 2.641 ± 0.095
1.345GlyPro: 1.345 ± 0.05
3.162GlyGln: 3.162 ± 0.078
2.716GlyArg: 2.716 ± 0.062
3.918GlySer: 3.918 ± 0.08
3.427GlyThr: 3.427 ± 0.074
4.669GlyVal: 4.669 ± 0.082
0.842GlyTrp: 0.842 ± 0.032
2.38GlyTyr: 2.38 ± 0.06
0.0GlyXaa: 0.0 ± 0.0
His
1.96HisAla: 1.96 ± 0.052
0.256HisCys: 0.256 ± 0.017
1.224HisAsp: 1.224 ± 0.035
1.203HisGlu: 1.203 ± 0.039
1.248HisPhe: 1.248 ± 0.04
1.431HisGly: 1.431 ± 0.043
0.769HisHis: 0.769 ± 0.032
1.674HisIle: 1.674 ± 0.042
1.038HisLys: 1.038 ± 0.037
2.491HisLeu: 2.491 ± 0.048
0.529HisMet: 0.529 ± 0.022
0.829HisAsn: 0.829 ± 0.029
1.272HisPro: 1.272 ± 0.036
1.324HisGln: 1.324 ± 0.037
1.008HisArg: 1.008 ± 0.038
1.377HisSer: 1.377 ± 0.041
1.097HisThr: 1.097 ± 0.033
1.515HisVal: 1.515 ± 0.046
0.333HisTrp: 0.333 ± 0.019
0.923HisTyr: 0.923 ± 0.031
0.0HisXaa: 0.0 ± 0.0
Ile
6.565IleAla: 6.565 ± 0.088
0.768IleCys: 0.768 ± 0.029
4.43IleAsp: 4.43 ± 0.076
4.912IleGlu: 4.912 ± 0.084
2.844IlePhe: 2.844 ± 0.067
4.638IleGly: 4.638 ± 0.084
1.573IleHis: 1.573 ± 0.038
4.175IleIle: 4.175 ± 0.079
3.848IleLys: 3.848 ± 0.065
6.349IleLeu: 6.349 ± 0.114
1.495IleMet: 1.495 ± 0.047
3.34IleAsn: 3.34 ± 0.066
2.981IlePro: 2.981 ± 0.072
3.76IleGln: 3.76 ± 0.069
2.987IleArg: 2.987 ± 0.058
4.823IleSer: 4.823 ± 0.077
3.535IleThr: 3.535 ± 0.086
4.379IleVal: 4.379 ± 0.087
0.743IleTrp: 0.743 ± 0.029
2.145IleTyr: 2.145 ± 0.045
0.0IleXaa: 0.0 ± 0.0
Lys
5.08LysAla: 5.08 ± 0.098
0.328LysCys: 0.328 ± 0.018
3.545LysAsp: 3.545 ± 0.187
3.121LysGlu: 3.121 ± 0.062
2.227LysPhe: 2.227 ± 0.05
3.222LysGly: 3.222 ± 0.073
1.387LysHis: 1.387 ± 0.041
4.341LysIle: 4.341 ± 0.077
3.85LysLys: 3.85 ± 0.094
5.552LysLeu: 5.552 ± 0.079
1.635LysMet: 1.635 ± 0.043
3.339LysAsn: 3.339 ± 0.065
2.364LysPro: 2.364 ± 0.056
3.247LysGln: 3.247 ± 0.066
2.589LysArg: 2.589 ± 0.051
3.703LysSer: 3.703 ± 0.075
3.562LysThr: 3.562 ± 0.073
3.913LysVal: 3.913 ± 0.071
0.631LysTrp: 0.631 ± 0.022
1.784LysTyr: 1.784 ± 0.043
0.0LysXaa: 0.0 ± 0.0
Leu
8.966LeuAla: 8.966 ± 0.112
1.049LeuCys: 1.049 ± 0.032
5.918LeuAsp: 5.918 ± 0.104
5.946LeuGlu: 5.946 ± 0.102
4.219LeuPhe: 4.219 ± 0.083
6.872LeuGly: 6.872 ± 0.108
1.998LeuHis: 1.998 ± 0.049
7.201LeuIle: 7.201 ± 0.097
7.027LeuLys: 7.027 ± 0.091
9.305LeuLeu: 9.305 ± 0.139
2.766LeuMet: 2.766 ± 0.058
5.773LeuAsn: 5.773 ± 0.11
4.208LeuPro: 4.208 ± 0.073
4.033LeuGln: 4.033 ± 0.083
3.893LeuArg: 3.893 ± 0.066
7.637LeuSer: 7.637 ± 0.096
5.514LeuThr: 5.514 ± 0.077
6.095LeuVal: 6.095 ± 0.088
1.079LeuTrp: 1.079 ± 0.043
2.774LeuTyr: 2.774 ± 0.063
0.0LeuXaa: 0.0 ± 0.0
Met
2.106MetAla: 2.106 ± 0.057
0.2MetCys: 0.2 ± 0.014
1.15MetAsp: 1.15 ± 0.035
0.959MetGlu: 0.959 ± 0.031
0.927MetPhe: 0.927 ± 0.037
1.695MetGly: 1.695 ± 0.039
0.536MetHis: 0.536 ± 0.025
1.749MetIle: 1.749 ± 0.052
1.478MetLys: 1.478 ± 0.039
2.546MetLeu: 2.546 ± 0.063
0.747MetMet: 0.747 ± 0.028
1.501MetAsn: 1.501 ± 0.032
1.106MetPro: 1.106 ± 0.032
1.405MetGln: 1.405 ± 0.038
1.107MetArg: 1.107 ± 0.035
1.961MetSer: 1.961 ± 0.05
1.588MetThr: 1.588 ± 0.042
1.576MetVal: 1.576 ± 0.043
0.216MetTrp: 0.216 ± 0.017
0.593MetTyr: 0.593 ± 0.025
0.0MetXaa: 0.0 ± 0.0
Asn
3.83AsnAla: 3.83 ± 0.064
0.395AsnCys: 0.395 ± 0.021
2.535AsnAsp: 2.535 ± 0.072
2.554AsnGlu: 2.554 ± 0.059
2.001AsnPhe: 2.001 ± 0.05
2.953AsnGly: 2.953 ± 0.08
1.18AsnHis: 1.18 ± 0.039
3.554AsnIle: 3.554 ± 0.065
2.775AsnLys: 2.775 ± 0.086
4.698AsnLeu: 4.698 ± 0.09
1.111AsnMet: 1.111 ± 0.034
2.312AsnAsn: 2.312 ± 0.076
2.407AsnPro: 2.407 ± 0.058
2.675AsnGln: 2.675 ± 0.076
1.921AsnArg: 1.921 ± 0.048
2.947AsnSer: 2.947 ± 0.079
2.901AsnThr: 2.901 ± 0.123
2.903AsnVal: 2.903 ± 0.072
0.539AsnTrp: 0.539 ± 0.024
1.507AsnTyr: 1.507 ± 0.04
0.0AsnXaa: 0.0 ± 0.0
Pro
2.935ProAla: 2.935 ± 0.063
0.264ProCys: 0.264 ± 0.016
2.077ProAsp: 2.077 ± 0.052
3.041ProGlu: 3.041 ± 0.07
1.672ProPhe: 1.672 ± 0.041
1.462ProGly: 1.462 ± 0.042
0.894ProHis: 0.894 ± 0.034
2.661ProIle: 2.661 ± 0.059
2.451ProLys: 2.451 ± 0.053
3.88ProLeu: 3.88 ± 0.064
0.928ProMet: 0.928 ± 0.031
2.021ProAsn: 2.021 ± 0.05
1.072ProPro: 1.072 ± 0.047
1.84ProGln: 1.84 ± 0.052
1.355ProArg: 1.355 ± 0.041
2.429ProSer: 2.429 ± 0.055
2.236ProThr: 2.236 ± 0.061
2.818ProVal: 2.818 ± 0.079
0.442ProTrp: 0.442 ± 0.021
1.259ProTyr: 1.259 ± 0.036
0.0ProXaa: 0.0 ± 0.0
Gln
4.802GlnAla: 4.802 ± 0.082
0.429GlnCys: 0.429 ± 0.024
2.483GlnAsp: 2.483 ± 0.053
2.344GlnGlu: 2.344 ± 0.05
2.096GlnPhe: 2.096 ± 0.043
3.034GlnGly: 3.034 ± 0.066
1.613GlnHis: 1.613 ± 0.05
3.598GlnIle: 3.598 ± 0.057
3.102GlnLys: 3.102 ± 0.063
5.382GlnLeu: 5.382 ± 0.1
1.199GlnMet: 1.199 ± 0.044
2.686GlnAsn: 2.686 ± 0.072
1.88GlnPro: 1.88 ± 0.05
3.443GlnGln: 3.443 ± 0.123
2.297GlnArg: 2.297 ± 0.054
3.168GlnSer: 3.168 ± 0.069
2.541GlnThr: 2.541 ± 0.057
3.276GlnVal: 3.276 ± 0.057
0.641GlnTrp: 0.641 ± 0.028
1.713GlnTyr: 1.713 ± 0.043
0.0GlnXaa: 0.0 ± 0.0
Arg
3.141ArgAla: 3.141 ± 0.067
0.372ArgCys: 0.372 ± 0.022
2.19ArgAsp: 2.19 ± 0.051
2.53ArgGlu: 2.53 ± 0.054
2.067ArgPhe: 2.067 ± 0.049
2.33ArgGly: 2.33 ± 0.06
1.008ArgHis: 1.008 ± 0.035
3.075ArgIle: 3.075 ± 0.062
2.373ArgLys: 2.373 ± 0.054
4.52ArgLeu: 4.52 ± 0.078
1.142ArgMet: 1.142 ± 0.037
1.855ArgAsn: 1.855 ± 0.049
1.601ArgPro: 1.601 ± 0.043
2.091ArgGln: 2.091 ± 0.053
1.937ArgArg: 1.937 ± 0.052
2.377ArgSer: 2.377 ± 0.054
1.982ArgThr: 1.982 ± 0.045
2.783ArgVal: 2.783 ± 0.059
0.458ArgTrp: 0.458 ± 0.021
1.64ArgTyr: 1.64 ± 0.04
0.0ArgXaa: 0.0 ± 0.0
Ser
5.068SerAla: 5.068 ± 0.079
0.557SerCys: 0.557 ± 0.027
3.353SerAsp: 3.353 ± 0.071
3.522SerGlu: 3.522 ± 0.058
2.939SerPhe: 2.939 ± 0.065
4.422SerGly: 4.422 ± 0.082
1.505SerHis: 1.505 ± 0.041
4.688SerIle: 4.688 ± 0.074
3.698SerLys: 3.698 ± 0.072
6.749SerLeu: 6.749 ± 0.094
1.584SerMet: 1.584 ± 0.041
3.306SerAsn: 3.306 ± 0.081
2.286SerPro: 2.286 ± 0.051
2.864SerGln: 2.864 ± 0.06
2.505SerArg: 2.505 ± 0.047
4.452SerSer: 4.452 ± 0.086
3.665SerThr: 3.665 ± 0.083
4.055SerVal: 4.055 ± 0.073
0.642SerTrp: 0.642 ± 0.025
2.114SerTyr: 2.114 ± 0.055
0.0SerXaa: 0.0 ± 0.0
Thr
5.059ThrAla: 5.059 ± 0.137
0.441ThrCys: 0.441 ± 0.024
2.841ThrAsp: 2.841 ± 0.069
3.17ThrGlu: 3.17 ± 0.067
2.051ThrPhe: 2.051 ± 0.05
4.089ThrGly: 4.089 ± 0.094
1.239ThrHis: 1.239 ± 0.033
3.38ThrIle: 3.38 ± 0.062
2.54ThrLys: 2.54 ± 0.063
5.801ThrLeu: 5.801 ± 0.094
1.027ThrMet: 1.027 ± 0.034
2.131ThrAsn: 2.131 ± 0.068
2.612ThrPro: 2.612 ± 0.078
2.902ThrGln: 2.902 ± 0.061
2.064ThrArg: 2.064 ± 0.046
2.989ThrSer: 2.989 ± 0.058
3.373ThrThr: 3.373 ± 0.125
3.854ThrVal: 3.854 ± 0.114
0.634ThrTrp: 0.634 ± 0.028
1.548ThrTyr: 1.548 ± 0.044
0.0ThrXaa: 0.0 ± 0.0
Val
5.612ValAla: 5.612 ± 0.095
0.688ValCys: 0.688 ± 0.028
3.94ValAsp: 3.94 ± 0.089
4.218ValGlu: 4.218 ± 0.076
2.682ValPhe: 2.682 ± 0.055
4.418ValGly: 4.418 ± 0.097
1.266ValHis: 1.266 ± 0.036
4.743ValIle: 4.743 ± 0.082
3.79ValLys: 3.79 ± 0.069
6.861ValLeu: 6.861 ± 0.099
1.771ValMet: 1.771 ± 0.045
3.053ValAsn: 3.053 ± 0.088
2.481ValPro: 2.481 ± 0.052
2.859ValGln: 2.859 ± 0.057
2.576ValArg: 2.576 ± 0.065
4.195ValSer: 4.195 ± 0.071
3.528ValThr: 3.528 ± 0.082
4.746ValVal: 4.746 ± 0.105
0.729ValTrp: 0.729 ± 0.026
1.839ValTyr: 1.839 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
0.803TrpAla: 0.803 ± 0.03
0.151TrpCys: 0.151 ± 0.012
0.528TrpAsp: 0.528 ± 0.025
0.453TrpGlu: 0.453 ± 0.019
0.602TrpPhe: 0.602 ± 0.029
0.671TrpGly: 0.671 ± 0.024
0.318TrpHis: 0.318 ± 0.017
0.905TrpIle: 0.905 ± 0.036
0.641TrpLys: 0.641 ± 0.025
1.528TrpLeu: 1.528 ± 0.045
0.386TrpMet: 0.386 ± 0.021
0.573TrpAsn: 0.573 ± 0.022
0.312TrpPro: 0.312 ± 0.02
0.71TrpGln: 0.71 ± 0.025
0.53TrpArg: 0.53 ± 0.024
0.757TrpSer: 0.757 ± 0.034
0.548TrpThr: 0.548 ± 0.024
0.823TrpVal: 0.823 ± 0.03
0.125TrpTrp: 0.125 ± 0.012
0.371TrpTyr: 0.371 ± 0.021
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.708TyrAla: 2.708 ± 0.052
0.359TyrCys: 0.359 ± 0.022
1.686TyrAsp: 1.686 ± 0.042
1.632TyrGlu: 1.632 ± 0.037
1.597TyrPhe: 1.597 ± 0.044
2.057TyrGly: 2.057 ± 0.051
0.718TyrHis: 0.718 ± 0.027
2.0TyrIle: 2.0 ± 0.048
1.825TyrLys: 1.825 ± 0.046
3.452TyrLeu: 3.452 ± 0.076
0.619TyrMet: 0.619 ± 0.025
1.316TyrAsn: 1.316 ± 0.04
1.349TyrPro: 1.349 ± 0.041
1.849TyrGln: 1.849 ± 0.045
1.54TyrArg: 1.54 ± 0.043
2.175TyrSer: 2.175 ± 0.054
1.567TyrThr: 1.567 ± 0.043
1.97TyrVal: 1.97 ± 0.05
0.48TyrTrp: 0.48 ± 0.024
1.012TyrTyr: 1.012 ± 0.036
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3287 proteins (989157 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski