Amino acid dipepetide frequency for Neisseria chenwenguii

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
16.156AlaAla: 16.156 ± 0.249
1.2AlaCys: 1.2 ± 0.043
6.692AlaAsp: 6.692 ± 0.118
7.848AlaGlu: 7.848 ± 0.131
4.215AlaPhe: 4.215 ± 0.094
8.655AlaGly: 8.655 ± 0.163
1.972AlaHis: 1.972 ± 0.058
3.867AlaIle: 3.867 ± 0.09
5.78AlaLys: 5.78 ± 0.116
11.405AlaLeu: 11.405 ± 0.157
2.683AlaMet: 2.683 ± 0.071
3.236AlaAsn: 3.236 ± 0.086
3.855AlaPro: 3.855 ± 0.102
5.244AlaGln: 5.244 ± 0.105
5.145AlaArg: 5.145 ± 0.095
4.604AlaSer: 4.604 ± 0.098
4.21AlaThr: 4.21 ± 0.104
9.896AlaVal: 9.896 ± 0.138
1.257AlaTrp: 1.257 ± 0.046
2.803AlaTyr: 2.803 ± 0.065
0.0AlaXaa: 0.0 ± 0.0
Cys
0.998CysAla: 0.998 ± 0.039
0.158CysCys: 0.158 ± 0.016
0.451CysAsp: 0.451 ± 0.031
0.518CysGlu: 0.518 ± 0.029
0.389CysPhe: 0.389 ± 0.023
1.109CysGly: 1.109 ± 0.051
0.27CysHis: 0.27 ± 0.027
0.501CysIle: 0.501 ± 0.031
0.392CysLys: 0.392 ± 0.027
0.915CysLeu: 0.915 ± 0.042
0.226CysMet: 0.226 ± 0.02
0.339CysAsn: 0.339 ± 0.022
0.495CysPro: 0.495 ± 0.03
0.31CysGln: 0.31 ± 0.021
0.69CysArg: 0.69 ± 0.029
0.539CysSer: 0.539 ± 0.026
0.526CysThr: 0.526 ± 0.028
0.6CysVal: 0.6 ± 0.031
0.082CysTrp: 0.082 ± 0.01
0.293CysTyr: 0.293 ± 0.021
0.0CysXaa: 0.0 ± 0.0
Asp
5.402AspAla: 5.402 ± 0.1
0.491AspCys: 0.491 ± 0.03
2.705AspAsp: 2.705 ± 0.075
3.457AspGlu: 3.457 ± 0.079
2.563AspPhe: 2.563 ± 0.067
4.698AspGly: 4.698 ± 0.125
0.846AspHis: 0.846 ± 0.037
3.37AspIle: 3.37 ± 0.075
3.045AspLys: 3.045 ± 0.071
5.206AspLeu: 5.206 ± 0.094
1.267AspMet: 1.267 ± 0.045
1.987AspAsn: 1.987 ± 0.059
1.846AspPro: 1.846 ± 0.054
1.206AspGln: 1.206 ± 0.045
2.196AspArg: 2.196 ± 0.05
2.688AspSer: 2.688 ± 0.072
2.98AspThr: 2.98 ± 0.084
3.703AspVal: 3.703 ± 0.09
0.919AspTrp: 0.919 ± 0.043
1.916AspTyr: 1.916 ± 0.056
0.0AspXaa: 0.0 ± 0.0
Glu
6.599GluAla: 6.599 ± 0.113
0.486GluCys: 0.486 ± 0.032
2.472GluAsp: 2.472 ± 0.067
3.384GluGlu: 3.384 ± 0.084
2.089GluPhe: 2.089 ± 0.054
3.499GluGly: 3.499 ± 0.08
1.41GluHis: 1.41 ± 0.045
4.017GluIle: 4.017 ± 0.081
4.025GluLys: 4.025 ± 0.086
5.329GluLeu: 5.329 ± 0.095
1.741GluMet: 1.741 ± 0.053
3.274GluAsn: 3.274 ± 0.07
1.987GluPro: 1.987 ± 0.061
2.898GluGln: 2.898 ± 0.074
3.511GluArg: 3.511 ± 0.083
3.025GluSer: 3.025 ± 0.068
3.932GluThr: 3.932 ± 0.076
3.666GluVal: 3.666 ± 0.088
0.81GluTrp: 0.81 ± 0.037
1.649GluTyr: 1.649 ± 0.051
0.0GluXaa: 0.0 ± 0.0
Phe
4.581PheAla: 4.581 ± 0.103
0.476PheCys: 0.476 ± 0.028
2.761PheAsp: 2.761 ± 0.069
2.238PheGlu: 2.238 ± 0.063
1.798PhePhe: 1.798 ± 0.064
3.666PheGly: 3.666 ± 0.084
0.814PheHis: 0.814 ± 0.033
2.209PheIle: 2.209 ± 0.065
1.869PheLys: 1.869 ± 0.056
3.644PheLeu: 3.644 ± 0.094
0.986PheMet: 0.986 ± 0.046
1.638PheAsn: 1.638 ± 0.053
1.547PhePro: 1.547 ± 0.052
1.481PheGln: 1.481 ± 0.048
1.808PheArg: 1.808 ± 0.058
2.726PheSer: 2.726 ± 0.071
2.24PheThr: 2.24 ± 0.058
2.805PheVal: 2.805 ± 0.072
0.618PheTrp: 0.618 ± 0.032
1.301PheTyr: 1.301 ± 0.05
0.0PheXaa: 0.0 ± 0.0
Gly
6.964GlyAla: 6.964 ± 0.112
0.893GlyCys: 0.893 ± 0.038
3.461GlyAsp: 3.461 ± 0.118
4.358GlyGlu: 4.358 ± 0.082
3.612GlyPhe: 3.612 ± 0.078
6.382GlyGly: 6.382 ± 0.123
1.524GlyHis: 1.524 ± 0.052
4.824GlyIle: 4.824 ± 0.088
5.175GlyLys: 5.175 ± 0.102
8.021GlyLeu: 8.021 ± 0.124
2.323GlyMet: 2.323 ± 0.066
3.142GlyAsn: 3.142 ± 0.136
1.211GlyPro: 1.211 ± 0.044
2.636GlyGln: 2.636 ± 0.069
4.739GlyArg: 4.739 ± 0.092
4.803GlySer: 4.803 ± 0.124
3.662GlyThr: 3.662 ± 0.104
5.511GlyVal: 5.511 ± 0.097
1.158GlyTrp: 1.158 ± 0.042
2.369GlyTyr: 2.369 ± 0.071
0.0GlyXaa: 0.0 ± 0.0
His
1.883HisAla: 1.883 ± 0.055
0.243HisCys: 0.243 ± 0.019
1.036HisAsp: 1.036 ± 0.041
1.184HisGlu: 1.184 ± 0.041
0.916HisPhe: 0.916 ± 0.037
1.75HisGly: 1.75 ± 0.057
0.6HisHis: 0.6 ± 0.036
1.375HisIle: 1.375 ± 0.043
0.892HisLys: 0.892 ± 0.037
2.025HisLeu: 2.025 ± 0.061
0.476HisMet: 0.476 ± 0.027
0.86HisAsn: 0.86 ± 0.039
1.243HisPro: 1.243 ± 0.047
0.763HisGln: 0.763 ± 0.035
1.079HisArg: 1.079 ± 0.04
1.064HisSer: 1.064 ± 0.036
1.269HisThr: 1.269 ± 0.045
1.134HisVal: 1.134 ± 0.038
0.316HisTrp: 0.316 ± 0.02
0.77HisTyr: 0.77 ± 0.033
0.0HisXaa: 0.0 ± 0.0
Ile
5.946IleAla: 5.946 ± 0.105
0.58IleCys: 0.58 ± 0.028
3.069IleAsp: 3.069 ± 0.064
3.355IleGlu: 3.355 ± 0.073
2.003IlePhe: 2.003 ± 0.065
4.642IleGly: 4.642 ± 0.104
1.176IleHis: 1.176 ± 0.044
2.761IleIle: 2.761 ± 0.08
2.43IleLys: 2.43 ± 0.065
4.887IleLeu: 4.887 ± 0.113
1.2IleMet: 1.2 ± 0.042
2.218IleAsn: 2.218 ± 0.064
2.474IlePro: 2.474 ± 0.066
1.851IleGln: 1.851 ± 0.049
3.121IleArg: 3.121 ± 0.069
3.247IleSer: 3.247 ± 0.08
3.045IleThr: 3.045 ± 0.074
3.7IleVal: 3.7 ± 0.083
0.591IleTrp: 0.591 ± 0.03
1.389IleTyr: 1.389 ± 0.048
0.0IleXaa: 0.0 ± 0.0
Lys
5.734LysAla: 5.734 ± 0.11
0.311LysCys: 0.311 ± 0.027
2.474LysAsp: 2.474 ± 0.075
2.838LysGlu: 2.838 ± 0.059
1.688LysPhe: 1.688 ± 0.051
3.495LysGly: 3.495 ± 0.083
1.146LysHis: 1.146 ± 0.038
3.315LysIle: 3.315 ± 0.079
3.062LysLys: 3.062 ± 0.082
5.11LysLeu: 5.11 ± 0.088
1.58LysMet: 1.58 ± 0.043
2.636LysAsn: 2.636 ± 0.07
2.679LysPro: 2.679 ± 0.077
2.565LysGln: 2.565 ± 0.078
2.817LysArg: 2.817 ± 0.075
2.654LysSer: 2.654 ± 0.06
3.657LysThr: 3.657 ± 0.066
3.28LysVal: 3.28 ± 0.081
0.559LysTrp: 0.559 ± 0.035
1.352LysTyr: 1.352 ± 0.044
0.0LysXaa: 0.0 ± 0.0
Leu
11.476LeuAla: 11.476 ± 0.176
0.997LeuCys: 0.997 ± 0.038
5.371LeuAsp: 5.371 ± 0.09
5.279LeuGlu: 5.279 ± 0.108
4.118LeuPhe: 4.118 ± 0.105
7.225LeuGly: 7.225 ± 0.116
2.098LeuHis: 2.098 ± 0.065
5.113LeuIle: 5.113 ± 0.115
5.765LeuLys: 5.765 ± 0.087
10.021LeuLeu: 10.021 ± 0.188
2.595LeuMet: 2.595 ± 0.07
4.303LeuAsn: 4.303 ± 0.092
5.649LeuPro: 5.649 ± 0.1
3.94LeuGln: 3.94 ± 0.077
4.908LeuArg: 4.908 ± 0.103
6.237LeuSer: 6.237 ± 0.097
5.607LeuThr: 5.607 ± 0.089
6.271LeuVal: 6.271 ± 0.13
1.173LeuTrp: 1.173 ± 0.054
2.537LeuTyr: 2.537 ± 0.071
0.0LeuXaa: 0.0 ± 0.0
Met
2.595MetAla: 2.595 ± 0.065
0.213MetCys: 0.213 ± 0.018
1.044MetAsp: 1.044 ± 0.039
1.134MetGlu: 1.134 ± 0.047
0.975MetPhe: 0.975 ± 0.039
1.828MetGly: 1.828 ± 0.053
0.432MetHis: 0.432 ± 0.027
1.272MetIle: 1.272 ± 0.045
1.609MetLys: 1.609 ± 0.052
2.808MetLeu: 2.808 ± 0.079
0.851MetMet: 0.851 ± 0.043
1.223MetAsn: 1.223 ± 0.038
1.498MetPro: 1.498 ± 0.049
1.22MetGln: 1.22 ± 0.047
1.419MetArg: 1.419 ± 0.049
1.522MetSer: 1.522 ± 0.049
1.489MetThr: 1.489 ± 0.051
1.652MetVal: 1.652 ± 0.055
0.219MetTrp: 0.219 ± 0.018
0.533MetTyr: 0.533 ± 0.033
0.0MetXaa: 0.0 ± 0.0
Asn
4.096AsnAla: 4.096 ± 0.102
0.366AsnCys: 0.366 ± 0.025
1.998AsnAsp: 1.998 ± 0.072
2.028AsnGlu: 2.028 ± 0.063
1.299AsnPhe: 1.299 ± 0.041
3.692AsnGly: 3.692 ± 0.106
0.81AsnHis: 0.81 ± 0.037
2.647AsnIle: 2.647 ± 0.076
1.852AsnLys: 1.852 ± 0.062
3.735AsnLeu: 3.735 ± 0.08
0.956AsnMet: 0.956 ± 0.036
1.51AsnAsn: 1.51 ± 0.079
2.515AsnPro: 2.515 ± 0.066
1.509AsnGln: 1.509 ± 0.052
2.402AsnArg: 2.402 ± 0.062
1.933AsnSer: 1.933 ± 0.066
2.284AsnThr: 2.284 ± 0.086
2.695AsnVal: 2.695 ± 0.108
0.536AsnTrp: 0.536 ± 0.029
1.064AsnTyr: 1.064 ± 0.042
0.0AsnXaa: 0.0 ± 0.0
Pro
4.656ProAla: 4.656 ± 0.102
0.36ProCys: 0.36 ± 0.024
2.755ProAsp: 2.755 ± 0.075
3.896ProGlu: 3.896 ± 0.088
1.869ProPhe: 1.869 ± 0.056
2.031ProGly: 2.031 ± 0.061
0.994ProHis: 0.994 ± 0.042
1.674ProIle: 1.674 ± 0.058
2.211ProLys: 2.211 ± 0.066
4.084ProLeu: 4.084 ± 0.094
0.983ProMet: 0.983 ± 0.037
1.694ProAsn: 1.694 ± 0.056
1.595ProPro: 1.595 ± 0.06
2.18ProGln: 2.18 ± 0.054
1.664ProArg: 1.664 ± 0.057
2.379ProSer: 2.379 ± 0.064
1.971ProThr: 1.971 ± 0.064
3.621ProVal: 3.621 ± 0.09
0.392ProTrp: 0.392 ± 0.024
1.26ProTyr: 1.26 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
4.806GlnAla: 4.806 ± 0.106
0.274GlnCys: 0.274 ± 0.021
1.725GlnAsp: 1.725 ± 0.052
2.188GlnGlu: 2.188 ± 0.07
1.488GlnPhe: 1.488 ± 0.053
2.743GlnGly: 2.743 ± 0.076
0.927GlnHis: 0.927 ± 0.036
2.531GlnIle: 2.531 ± 0.069
2.17GlnLys: 2.17 ± 0.067
3.247GlnLeu: 3.247 ± 0.073
1.097GlnMet: 1.097 ± 0.041
2.228GlnAsn: 2.228 ± 0.074
1.647GlnPro: 1.647 ± 0.054
2.097GlnGln: 2.097 ± 0.076
2.065GlnArg: 2.065 ± 0.065
2.351GlnSer: 2.351 ± 0.073
3.376GlnThr: 3.376 ± 0.083
2.265GlnVal: 2.265 ± 0.066
0.555GlnTrp: 0.555 ± 0.03
1.241GlnTyr: 1.241 ± 0.044
0.0GlnXaa: 0.0 ± 0.0
Arg
4.804ArgAla: 4.804 ± 0.085
0.422ArgCys: 0.422 ± 0.022
2.702ArgAsp: 2.702 ± 0.084
3.34ArgGlu: 3.34 ± 0.088
2.695ArgPhe: 2.695 ± 0.073
3.191ArgGly: 3.191 ± 0.075
1.337ArgHis: 1.337 ± 0.051
3.246ArgIle: 3.246 ± 0.064
2.636ArgLys: 2.636 ± 0.067
6.287ArgLeu: 6.287 ± 0.116
1.392ArgMet: 1.392 ± 0.048
2.089ArgAsn: 2.089 ± 0.053
2.214ArgPro: 2.214 ± 0.067
2.486ArgGln: 2.486 ± 0.068
3.531ArgArg: 3.531 ± 0.099
2.644ArgSer: 2.644 ± 0.062
2.329ArgThr: 2.329 ± 0.064
3.343ArgVal: 3.343 ± 0.078
0.599ArgTrp: 0.599 ± 0.033
2.042ArgTyr: 2.042 ± 0.064
0.0ArgXaa: 0.0 ± 0.0
Ser
5.712SerAla: 5.712 ± 0.103
0.514SerCys: 0.514 ± 0.028
3.44SerAsp: 3.44 ± 0.086
3.604SerGlu: 3.604 ± 0.079
2.24SerPhe: 2.24 ± 0.06
5.47SerGly: 5.47 ± 0.094
1.112SerHis: 1.112 ± 0.039
2.55SerIle: 2.55 ± 0.067
2.452SerLys: 2.452 ± 0.062
5.522SerLeu: 5.522 ± 0.101
1.197SerMet: 1.197 ± 0.045
1.919SerAsn: 1.919 ± 0.064
2.272SerPro: 2.272 ± 0.057
1.93SerGln: 1.93 ± 0.057
3.034SerArg: 3.034 ± 0.064
2.817SerSer: 2.817 ± 0.075
2.358SerThr: 2.358 ± 0.081
4.03SerVal: 4.03 ± 0.094
0.655SerTrp: 0.655 ± 0.032
1.509SerTyr: 1.509 ± 0.045
0.0SerXaa: 0.0 ± 0.0
Thr
7.146ThrAla: 7.146 ± 0.147
0.432ThrCys: 0.432 ± 0.033
3.053ThrAsp: 3.053 ± 0.077
2.977ThrGlu: 2.977 ± 0.066
1.949ThrPhe: 1.949 ± 0.055
4.361ThrGly: 4.361 ± 0.105
1.02ThrHis: 1.02 ± 0.037
2.392ThrIle: 2.392 ± 0.07
1.884ThrLys: 1.884 ± 0.058
6.003ThrLeu: 6.003 ± 0.095
1.029ThrMet: 1.029 ± 0.038
1.603ThrAsn: 1.603 ± 0.073
2.86ThrPro: 2.86 ± 0.065
1.921ThrGln: 1.921 ± 0.06
2.659ThrArg: 2.659 ± 0.068
2.217ThrSer: 2.217 ± 0.064
2.282ThrThr: 2.282 ± 0.081
4.996ThrVal: 4.996 ± 0.111
0.536ThrTrp: 0.536 ± 0.03
1.296ThrTyr: 1.296 ± 0.048
0.0ThrXaa: 0.0 ± 0.0
Val
7.236ValAla: 7.236 ± 0.148
0.901ValCys: 0.901 ± 0.043
3.258ValAsp: 3.258 ± 0.077
4.139ValGlu: 4.139 ± 0.093
3.215ValPhe: 3.215 ± 0.075
5.072ValGly: 5.072 ± 0.102
1.396ValHis: 1.396 ± 0.045
3.932ValIle: 3.932 ± 0.087
3.89ValLys: 3.89 ± 0.096
7.553ValLeu: 7.553 ± 0.129
2.069ValMet: 2.069 ± 0.062
2.61ValAsn: 2.61 ± 0.092
2.896ValPro: 2.896 ± 0.071
2.443ValGln: 2.443 ± 0.061
3.707ValArg: 3.707 ± 0.082
4.859ValSer: 4.859 ± 0.094
3.299ValThr: 3.299 ± 0.099
5.098ValVal: 5.098 ± 0.11
0.982ValTrp: 0.982 ± 0.043
2.155ValTyr: 2.155 ± 0.063
0.0ValXaa: 0.0 ± 0.0
Trp
1.086TrpAla: 1.086 ± 0.039
0.134TrpCys: 0.134 ± 0.013
0.535TrpAsp: 0.535 ± 0.033
0.552TrpGlu: 0.552 ± 0.032
0.676TrpPhe: 0.676 ± 0.036
0.799TrpGly: 0.799 ± 0.039
0.343TrpHis: 0.343 ± 0.021
0.637TrpIle: 0.637 ± 0.033
0.594TrpLys: 0.594 ± 0.032
1.867TrpLeu: 1.867 ± 0.066
0.34TrpMet: 0.34 ± 0.024
0.483TrpAsn: 0.483 ± 0.03
0.348TrpPro: 0.348 ± 0.021
1.007TrpGln: 1.007 ± 0.037
0.779TrpArg: 0.779 ± 0.036
0.501TrpSer: 0.501 ± 0.028
0.529TrpThr: 0.529 ± 0.032
0.798TrpVal: 0.798 ± 0.035
0.175TrpTrp: 0.175 ± 0.021
0.363TrpTyr: 0.363 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.847TyrAla: 2.847 ± 0.068
0.353TyrCys: 0.353 ± 0.029
1.491TyrAsp: 1.491 ± 0.049
1.491TyrGlu: 1.491 ± 0.046
1.409TyrPhe: 1.409 ± 0.051
2.46TyrGly: 2.46 ± 0.07
0.649TyrHis: 0.649 ± 0.034
1.45TyrIle: 1.45 ± 0.047
1.222TyrLys: 1.222 ± 0.042
3.015TyrLeu: 3.015 ± 0.07
0.541TyrMet: 0.541 ± 0.029
0.933TyrAsn: 0.933 ± 0.045
1.439TyrPro: 1.439 ± 0.047
1.333TyrGln: 1.333 ± 0.054
2.056TyrArg: 2.056 ± 0.061
1.524TyrSer: 1.524 ± 0.045
1.57TyrThr: 1.57 ± 0.051
1.647TyrVal: 1.647 ± 0.044
0.416TyrTrp: 0.416 ± 0.024
0.874TyrTyr: 0.874 ± 0.038
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2219 proteins (658136 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski