Amino acid dipepetide frequency for Streptococcus satellite phage Javan313

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.332AlaAla: 0.332 ± 0.326
0.664AlaCys: 0.664 ± 0.445
3.318AlaAsp: 3.318 ± 1.274
7.963AlaGlu: 7.963 ± 1.954
4.645AlaPhe: 4.645 ± 1.244
2.654AlaGly: 2.654 ± 0.973
0.664AlaHis: 0.664 ± 0.471
3.981AlaIle: 3.981 ± 0.901
5.972AlaLys: 5.972 ± 0.956
3.65AlaLeu: 3.65 ± 0.619
3.318AlaMet: 3.318 ± 1.477
2.986AlaAsn: 2.986 ± 0.839
1.991AlaPro: 1.991 ± 0.652
1.659AlaGln: 1.659 ± 0.588
2.986AlaArg: 2.986 ± 1.155
2.322AlaSer: 2.322 ± 0.848
4.313AlaThr: 4.313 ± 0.726
2.654AlaVal: 2.654 ± 0.821
0.332AlaTrp: 0.332 ± 0.318
1.327AlaTyr: 1.327 ± 0.534
0.0AlaXaa: 0.0 ± 0.0
Cys
0.0CysAla: 0.0 ± 0.0
0.0CysCys: 0.0 ± 0.0
1.659CysAsp: 1.659 ± 0.774
0.0CysGlu: 0.0 ± 0.0
0.0CysPhe: 0.0 ± 0.0
0.332CysGly: 0.332 ± 0.288
0.332CysHis: 0.332 ± 0.325
0.332CysIle: 0.332 ± 0.314
0.332CysLys: 0.332 ± 0.318
0.664CysLeu: 0.664 ± 0.431
0.0CysMet: 0.0 ± 0.0
0.995CysAsn: 0.995 ± 0.671
0.332CysPro: 0.332 ± 0.325
0.332CysGln: 0.332 ± 0.31
0.0CysArg: 0.0 ± 0.0
0.332CysSer: 0.332 ± 0.334
0.664CysThr: 0.664 ± 0.427
0.0CysVal: 0.0 ± 0.0
0.0CysTrp: 0.0 ± 0.0
0.0CysTyr: 0.0 ± 0.0
0.0CysXaa: 0.0 ± 0.0
Asp
0.664AspAla: 0.664 ± 0.431
0.332AspCys: 0.332 ± 0.314
1.991AspAsp: 1.991 ± 0.728
3.981AspGlu: 3.981 ± 0.891
4.645AspPhe: 4.645 ± 1.335
2.654AspGly: 2.654 ± 0.771
0.664AspHis: 0.664 ± 0.439
3.981AspIle: 3.981 ± 1.228
5.309AspLys: 5.309 ± 1.09
5.309AspLeu: 5.309 ± 0.855
1.659AspMet: 1.659 ± 0.538
2.986AspAsn: 2.986 ± 0.813
0.332AspPro: 0.332 ± 0.314
0.995AspGln: 0.995 ± 0.545
3.318AspArg: 3.318 ± 1.251
2.654AspSer: 2.654 ± 1.004
2.986AspThr: 2.986 ± 0.92
4.645AspVal: 4.645 ± 1.237
0.332AspTrp: 0.332 ± 0.318
4.313AspTyr: 4.313 ± 1.072
0.0AspXaa: 0.0 ± 0.0
Glu
5.309GluAla: 5.309 ± 1.596
0.664GluCys: 0.664 ± 0.433
3.981GluAsp: 3.981 ± 1.356
6.967GluGlu: 6.967 ± 1.718
2.654GluPhe: 2.654 ± 0.767
2.654GluGly: 2.654 ± 1.063
1.991GluHis: 1.991 ± 0.545
5.309GluIle: 5.309 ± 1.292
9.954GluLys: 9.954 ± 1.159
7.631GluLeu: 7.631 ± 0.838
2.986GluMet: 2.986 ± 0.901
3.981GluAsn: 3.981 ± 1.062
3.65GluPro: 3.65 ± 1.009
4.313GluGln: 4.313 ± 1.738
5.64GluArg: 5.64 ± 2.031
2.654GluSer: 2.654 ± 1.16
4.313GluThr: 4.313 ± 1.528
4.645GluVal: 4.645 ± 1.713
0.995GluTrp: 0.995 ± 0.666
5.972GluTyr: 5.972 ± 1.136
0.0GluXaa: 0.0 ± 0.0
Phe
1.327PheAla: 1.327 ± 0.629
0.332PheCys: 0.332 ± 0.31
4.645PheAsp: 4.645 ± 1.116
6.967PheGlu: 6.967 ± 1.925
2.986PhePhe: 2.986 ± 1.047
3.318PheGly: 3.318 ± 1.09
0.664PheHis: 0.664 ± 0.412
3.318PheIle: 3.318 ± 1.017
4.977PheLys: 4.977 ± 0.844
2.986PheLeu: 2.986 ± 0.815
1.327PheMet: 1.327 ± 0.659
5.309PheAsn: 5.309 ± 1.533
0.332PhePro: 0.332 ± 0.408
1.991PheGln: 1.991 ± 0.745
2.986PheArg: 2.986 ± 1.035
2.986PheSer: 2.986 ± 0.746
3.318PheThr: 3.318 ± 1.168
1.327PheVal: 1.327 ± 0.729
0.995PheTrp: 0.995 ± 0.573
1.991PheTyr: 1.991 ± 0.632
0.0PheXaa: 0.0 ± 0.0
Gly
2.654GlyAla: 2.654 ± 1.94
0.332GlyCys: 0.332 ± 0.325
2.986GlyAsp: 2.986 ± 1.268
3.318GlyGlu: 3.318 ± 1.163
2.654GlyPhe: 2.654 ± 1.004
1.991GlyGly: 1.991 ± 0.607
0.995GlyHis: 0.995 ± 0.482
3.65GlyIle: 3.65 ± 1.161
3.65GlyLys: 3.65 ± 1.197
5.309GlyLeu: 5.309 ± 1.365
0.332GlyMet: 0.332 ± 0.3
2.322GlyAsn: 2.322 ± 0.982
0.0GlyPro: 0.0 ± 0.0
1.659GlyGln: 1.659 ± 0.577
1.991GlyArg: 1.991 ± 0.705
2.322GlySer: 2.322 ± 0.799
3.65GlyThr: 3.65 ± 1.322
1.991GlyVal: 1.991 ± 0.833
0.664GlyTrp: 0.664 ± 0.637
2.654GlyTyr: 2.654 ± 0.936
0.0GlyXaa: 0.0 ± 0.0
His
2.986HisAla: 2.986 ± 0.918
0.0HisCys: 0.0 ± 0.0
0.664HisAsp: 0.664 ± 0.48
0.995HisGlu: 0.995 ± 0.628
0.995HisPhe: 0.995 ± 0.455
1.327HisGly: 1.327 ± 0.847
0.332HisHis: 0.332 ± 0.318
0.664HisIle: 0.664 ± 0.44
2.322HisLys: 2.322 ± 1.084
2.322HisLeu: 2.322 ± 0.746
0.332HisMet: 0.332 ± 0.317
0.664HisAsn: 0.664 ± 0.383
0.332HisPro: 0.332 ± 0.326
0.332HisGln: 0.332 ± 0.318
0.664HisArg: 0.664 ± 0.472
1.327HisSer: 1.327 ± 0.452
1.659HisThr: 1.659 ± 0.799
0.664HisVal: 0.664 ± 0.427
0.0HisTrp: 0.0 ± 0.0
0.664HisTyr: 0.664 ± 0.474
0.0HisXaa: 0.0 ± 0.0
Ile
4.645IleAla: 4.645 ± 1.453
0.664IleCys: 0.664 ± 0.414
4.313IleAsp: 4.313 ± 1.124
7.963IleGlu: 7.963 ± 1.945
3.318IlePhe: 3.318 ± 1.063
3.318IleGly: 3.318 ± 0.549
0.995IleHis: 0.995 ± 0.674
3.65IleIle: 3.65 ± 0.999
6.636IleLys: 6.636 ± 1.55
4.645IleLeu: 4.645 ± 0.836
0.332IleMet: 0.332 ± 0.318
3.981IleAsn: 3.981 ± 1.296
3.318IlePro: 3.318 ± 0.973
2.654IleGln: 2.654 ± 0.913
2.986IleArg: 2.986 ± 0.681
5.309IleSer: 5.309 ± 1.181
3.65IleThr: 3.65 ± 1.109
3.65IleVal: 3.65 ± 0.85
0.0IleTrp: 0.0 ± 0.0
2.322IleTyr: 2.322 ± 0.772
0.0IleXaa: 0.0 ± 0.0
Lys
7.631LysAla: 7.631 ± 1.26
0.332LysCys: 0.332 ± 0.334
3.318LysAsp: 3.318 ± 1.349
9.622LysGlu: 9.622 ± 1.191
3.318LysPhe: 3.318 ± 0.834
3.981LysGly: 3.981 ± 1.515
4.977LysHis: 4.977 ± 0.949
7.963LysIle: 7.963 ± 1.478
6.636LysLys: 6.636 ± 1.934
6.636LysLeu: 6.636 ± 1.341
2.322LysMet: 2.322 ± 0.848
3.981LysAsn: 3.981 ± 0.85
2.986LysPro: 2.986 ± 1.536
2.654LysGln: 2.654 ± 0.838
5.972LysArg: 5.972 ± 1.649
4.645LysSer: 4.645 ± 1.113
6.304LysThr: 6.304 ± 1.892
5.972LysVal: 5.972 ± 0.879
0.664LysTrp: 0.664 ± 0.405
2.322LysTyr: 2.322 ± 0.928
0.0LysXaa: 0.0 ± 0.0
Leu
5.972LeuAla: 5.972 ± 1.142
0.664LeuCys: 0.664 ± 0.383
7.299LeuAsp: 7.299 ± 1.448
7.963LeuGlu: 7.963 ± 1.831
4.313LeuPhe: 4.313 ± 1.39
1.991LeuGly: 1.991 ± 1.101
1.327LeuHis: 1.327 ± 0.756
4.977LeuIle: 4.977 ± 1.53
7.963LeuLys: 7.963 ± 1.833
10.949LeuLeu: 10.949 ± 1.876
1.991LeuMet: 1.991 ± 0.854
5.309LeuAsn: 5.309 ± 1.329
3.318LeuPro: 3.318 ± 1.448
3.65LeuGln: 3.65 ± 0.732
2.986LeuArg: 2.986 ± 0.989
5.972LeuSer: 5.972 ± 1.216
7.631LeuThr: 7.631 ± 1.922
6.304LeuVal: 6.304 ± 0.935
0.664LeuTrp: 0.664 ± 0.467
2.986LeuTyr: 2.986 ± 0.789
0.0LeuXaa: 0.0 ± 0.0
Met
1.991MetAla: 1.991 ± 0.884
0.0MetCys: 0.0 ± 0.0
2.322MetAsp: 2.322 ± 0.959
1.991MetGlu: 1.991 ± 0.904
0.664MetPhe: 0.664 ± 0.51
1.659MetGly: 1.659 ± 0.798
0.0MetHis: 0.0 ± 0.0
1.327MetIle: 1.327 ± 0.48
1.991MetLys: 1.991 ± 0.757
1.991MetLeu: 1.991 ± 0.731
0.332MetMet: 0.332 ± 0.334
1.659MetAsn: 1.659 ± 0.695
0.664MetPro: 0.664 ± 0.406
1.327MetGln: 1.327 ± 0.611
0.995MetArg: 0.995 ± 0.434
0.995MetSer: 0.995 ± 0.467
3.318MetThr: 3.318 ± 1.321
0.995MetVal: 0.995 ± 0.521
0.0MetTrp: 0.0 ± 0.0
0.995MetTyr: 0.995 ± 0.546
0.0MetXaa: 0.0 ± 0.0
Asn
3.65AsnAla: 3.65 ± 1.433
0.332AsnCys: 0.332 ± 0.334
3.318AsnAsp: 3.318 ± 1.035
2.986AsnGlu: 2.986 ± 0.873
3.318AsnPhe: 3.318 ± 1.203
3.981AsnGly: 3.981 ± 0.875
0.995AsnHis: 0.995 ± 0.551
2.654AsnIle: 2.654 ± 0.808
5.309AsnLys: 5.309 ± 0.847
4.645AsnLeu: 4.645 ± 1.421
1.991AsnMet: 1.991 ± 1.075
3.318AsnAsn: 3.318 ± 1.253
2.322AsnPro: 2.322 ± 0.918
2.654AsnGln: 2.654 ± 0.942
0.995AsnArg: 0.995 ± 0.698
3.65AsnSer: 3.65 ± 0.968
2.986AsnThr: 2.986 ± 1.011
1.991AsnVal: 1.991 ± 0.727
0.664AsnTrp: 0.664 ± 0.433
2.654AsnTyr: 2.654 ± 0.738
0.0AsnXaa: 0.0 ± 0.0
Pro
2.322ProAla: 2.322 ± 0.762
0.0ProCys: 0.0 ± 0.0
2.322ProAsp: 2.322 ± 0.674
2.322ProGlu: 2.322 ± 0.931
3.318ProPhe: 3.318 ± 1.161
0.995ProGly: 0.995 ± 0.5
0.664ProHis: 0.664 ± 0.427
1.327ProIle: 1.327 ± 0.57
2.322ProLys: 2.322 ± 1.152
1.991ProLeu: 1.991 ± 0.834
0.664ProMet: 0.664 ± 0.455
2.322ProAsn: 2.322 ± 1.561
0.995ProPro: 0.995 ± 0.666
1.991ProGln: 1.991 ± 0.977
2.322ProArg: 2.322 ± 0.957
1.991ProSer: 1.991 ± 0.811
0.995ProThr: 0.995 ± 0.453
2.322ProVal: 2.322 ± 1.005
0.332ProTrp: 0.332 ± 0.318
1.659ProTyr: 1.659 ± 0.696
0.0ProXaa: 0.0 ± 0.0
Gln
4.977GlnAla: 4.977 ± 1.942
0.332GlnCys: 0.332 ± 0.288
0.332GlnAsp: 0.332 ± 0.392
3.318GlnGlu: 3.318 ± 0.983
1.991GlnPhe: 1.991 ± 0.763
0.995GlnGly: 0.995 ± 0.626
0.995GlnHis: 0.995 ± 0.455
2.654GlnIle: 2.654 ± 0.968
2.986GlnLys: 2.986 ± 1.031
3.65GlnLeu: 3.65 ± 0.716
0.332GlnMet: 0.332 ± 0.608
2.654GlnAsn: 2.654 ± 1.031
0.995GlnPro: 0.995 ± 0.68
2.322GlnGln: 2.322 ± 0.777
2.322GlnArg: 2.322 ± 0.824
1.659GlnSer: 1.659 ± 0.685
2.322GlnThr: 2.322 ± 0.667
3.318GlnVal: 3.318 ± 1.126
0.664GlnTrp: 0.664 ± 0.44
0.664GlnTyr: 0.664 ± 0.415
0.0GlnXaa: 0.0 ± 0.0
Arg
2.654ArgAla: 2.654 ± 0.701
0.0ArgCys: 0.0 ± 0.0
2.322ArgAsp: 2.322 ± 0.979
3.318ArgGlu: 3.318 ± 0.875
3.318ArgPhe: 3.318 ± 1.001
1.991ArgGly: 1.991 ± 0.875
0.664ArgHis: 0.664 ± 0.461
2.322ArgIle: 2.322 ± 1.023
3.981ArgLys: 3.981 ± 0.803
4.977ArgLeu: 4.977 ± 1.749
0.995ArgMet: 0.995 ± 0.52
3.65ArgAsn: 3.65 ± 1.027
1.659ArgPro: 1.659 ± 0.575
1.991ArgGln: 1.991 ± 0.84
0.995ArgArg: 0.995 ± 0.507
1.659ArgSer: 1.659 ± 0.514
3.318ArgThr: 3.318 ± 1.09
3.65ArgVal: 3.65 ± 0.692
0.664ArgTrp: 0.664 ± 0.51
2.654ArgTyr: 2.654 ± 1.175
0.0ArgXaa: 0.0 ± 0.0
Ser
1.991SerAla: 1.991 ± 0.652
0.332SerCys: 0.332 ± 0.324
1.991SerAsp: 1.991 ± 0.762
4.645SerGlu: 4.645 ± 1.663
2.654SerPhe: 2.654 ± 1.341
2.986SerGly: 2.986 ± 0.601
0.332SerHis: 0.332 ± 0.325
6.636SerIle: 6.636 ± 1.179
4.313SerLys: 4.313 ± 0.944
6.304SerLeu: 6.304 ± 1.226
1.327SerMet: 1.327 ± 0.69
2.654SerAsn: 2.654 ± 0.866
1.991SerPro: 1.991 ± 0.959
1.991SerGln: 1.991 ± 0.777
2.322SerArg: 2.322 ± 1.193
4.313SerSer: 4.313 ± 1.009
3.318SerThr: 3.318 ± 0.76
0.995SerVal: 0.995 ± 0.496
0.332SerTrp: 0.332 ± 0.318
1.659SerTyr: 1.659 ± 1.083
0.0SerXaa: 0.0 ± 0.0
Thr
2.322ThrAla: 2.322 ± 0.859
0.0ThrCys: 0.0 ± 0.0
2.654ThrAsp: 2.654 ± 0.585
4.313ThrGlu: 4.313 ± 0.848
4.977ThrPhe: 4.977 ± 2.243
3.65ThrGly: 3.65 ± 0.608
0.995ThrHis: 0.995 ± 0.402
5.309ThrIle: 5.309 ± 1.216
5.309ThrLys: 5.309 ± 1.095
7.963ThrLeu: 7.963 ± 1.298
1.659ThrMet: 1.659 ± 0.52
2.322ThrAsn: 2.322 ± 1.676
2.654ThrPro: 2.654 ± 0.791
2.654ThrGln: 2.654 ± 1.027
3.318ThrArg: 3.318 ± 0.68
3.318ThrSer: 3.318 ± 0.572
3.65ThrThr: 3.65 ± 1.436
4.645ThrVal: 4.645 ± 1.53
0.332ThrTrp: 0.332 ± 0.314
2.986ThrTyr: 2.986 ± 1.506
0.0ThrXaa: 0.0 ± 0.0
Val
4.313ValAla: 4.313 ± 1.13
0.332ValCys: 0.332 ± 0.318
2.654ValAsp: 2.654 ± 1.345
3.65ValGlu: 3.65 ± 1.208
2.654ValPhe: 2.654 ± 1.267
2.322ValGly: 2.322 ± 0.707
0.332ValHis: 0.332 ± 0.335
3.65ValIle: 3.65 ± 0.968
6.304ValLys: 6.304 ± 1.304
6.967ValLeu: 6.967 ± 1.588
0.995ValMet: 0.995 ± 0.597
1.991ValAsn: 1.991 ± 0.914
2.654ValPro: 2.654 ± 1.182
2.654ValGln: 2.654 ± 0.992
1.327ValArg: 1.327 ± 0.918
2.654ValSer: 2.654 ± 0.903
4.645ValThr: 4.645 ± 1.023
2.654ValVal: 2.654 ± 1.11
0.332ValTrp: 0.332 ± 0.391
1.991ValTyr: 1.991 ± 0.707
0.0ValXaa: 0.0 ± 0.0
Trp
0.332TrpAla: 0.332 ± 0.325
0.0TrpCys: 0.0 ± 0.0
0.332TrpAsp: 0.332 ± 0.318
0.995TrpGlu: 0.995 ± 0.58
0.0TrpPhe: 0.0 ± 0.0
0.332TrpGly: 0.332 ± 0.391
0.332TrpHis: 0.332 ± 0.318
0.664TrpIle: 0.664 ± 0.404
0.332TrpLys: 0.332 ± 0.288
0.995TrpLeu: 0.995 ± 0.518
0.0TrpMet: 0.0 ± 0.0
0.332TrpAsn: 0.332 ± 0.318
0.664TrpPro: 0.664 ± 0.406
0.332TrpGln: 0.332 ± 0.318
0.332TrpArg: 0.332 ± 0.318
0.664TrpSer: 0.664 ± 0.426
0.0TrpThr: 0.0 ± 0.0
0.995TrpVal: 0.995 ± 0.483
0.0TrpTrp: 0.0 ± 0.0
0.332TrpTyr: 0.332 ± 0.318
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.659TyrAla: 1.659 ± 0.849
0.995TyrCys: 0.995 ± 0.473
1.327TyrAsp: 1.327 ± 0.554
2.986TyrGlu: 2.986 ± 0.841
1.659TyrPhe: 1.659 ± 0.868
1.991TyrGly: 1.991 ± 0.606
0.995TyrHis: 0.995 ± 0.572
3.981TyrIle: 3.981 ± 1.053
5.64TyrLys: 5.64 ± 1.503
4.645TyrLeu: 4.645 ± 1.064
1.991TyrMet: 1.991 ± 0.58
0.995TyrAsn: 0.995 ± 0.536
1.991TyrPro: 1.991 ± 1.031
1.659TyrGln: 1.659 ± 0.649
2.322TyrArg: 2.322 ± 0.793
1.659TyrSer: 1.659 ± 0.56
1.991TyrThr: 1.991 ± 0.561
1.659TyrVal: 1.659 ± 0.6
0.0TyrTrp: 0.0 ± 0.0
2.322TyrTyr: 2.322 ± 1.074
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 17 proteins (3015 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski