Amino acid dipepetide frequency for Crateriforma conspicua

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	11.405AlaAla: 11.405 ± 0.101	1.141AlaCys: 1.141 ± 0.032	7.669AlaAsp: 7.669 ± 0.082	5.864AlaGlu: 5.864 ± 0.065	3.3AlaPhe: 3.3 ± 0.047	8.226AlaGly: 8.226 ± 0.076	1.429AlaHis: 1.429 ± 0.029	5.585AlaIle: 5.585 ± 0.06	3.734AlaLys: 3.734 ± 0.059	7.56AlaLeu: 7.56 ± 0.075	2.957AlaMet: 2.957 ± 0.045	2.893AlaAsn: 2.893 ± 0.047	3.848AlaPro: 3.848 ± 0.047	3.174AlaGln: 3.174 ± 0.043	4.92AlaArg: 4.92 ± 0.057	6.696AlaSer: 6.696 ± 0.082	6.036AlaThr: 6.036 ± 0.071	7.252AlaVal: 7.252 ± 0.069	1.359AlaTrp: 1.359 ± 0.029	1.95AlaTyr: 1.95 ± 0.036	0.0AlaXaa: 0.0 ± 0.0
Cys	0.731CysAla: 0.731 ± 0.022	0.244CysCys: 0.244 ± 0.015	0.903CysAsp: 0.903 ± 0.027	0.652CysGlu: 0.652 ± 0.024	0.457CysPhe: 0.457 ± 0.017	1.193CysGly: 1.193 ± 0.029	0.452CysHis: 0.452 ± 0.019	0.472CysIle: 0.472 ± 0.016	0.285CysLys: 0.285 ± 0.012	1.149CysLeu: 1.149 ± 0.025	0.204CysMet: 0.204 ± 0.01	0.337CysAsn: 0.337 ± 0.012	0.632CysPro: 0.632 ± 0.02	0.485CysGln: 0.485 ± 0.014	0.918CysArg: 0.918 ± 0.024	0.642CysSer: 0.642 ± 0.019	0.537CysThr: 0.537 ± 0.019	0.933CysVal: 0.933 ± 0.023	0.189CysTrp: 0.189 ± 0.01	0.289CysTyr: 0.289 ± 0.011	0.0CysXaa: 0.0 ± 0.0
Asp	7.908AspAla: 7.908 ± 0.085	0.704AspCys: 0.704 ± 0.019	6.023AspAsp: 6.023 ± 0.078	4.397AspGlu: 4.397 ± 0.058	2.522AspPhe: 2.522 ± 0.049	6.352AspGly: 6.352 ± 0.097	1.76AspHis: 1.76 ± 0.038	2.659AspIle: 2.659 ± 0.043	1.585AspLys: 1.585 ± 0.035	6.504AspLeu: 6.504 ± 0.063	1.133AspMet: 1.133 ± 0.021	1.806AspAsn: 1.806 ± 0.04	4.319AspPro: 4.319 ± 0.058	3.616AspGln: 3.616 ± 0.043	5.431AspArg: 5.431 ± 0.061	4.29AspSer: 4.29 ± 0.06	3.14AspThr: 3.14 ± 0.062	5.362AspVal: 5.362 ± 0.06	1.245AspTrp: 1.245 ± 0.027	1.673AspTyr: 1.673 ± 0.031	0.0AspXaa: 0.0 ± 0.0
Glu	5.025GluAla: 5.025 ± 0.059	0.457GluCys: 0.457 ± 0.018	2.85GluAsp: 2.85 ± 0.044	2.502GluGlu: 2.502 ± 0.049	2.038GluPhe: 2.038 ± 0.037	3.306GluGly: 3.306 ± 0.043	1.156GluHis: 1.156 ± 0.025	3.219GluIle: 3.219 ± 0.043	2.058GluLys: 2.058 ± 0.039	5.654GluLeu: 5.654 ± 0.066	1.396GluMet: 1.396 ± 0.031	1.879GluAsn: 1.879 ± 0.034	2.507GluPro: 2.507 ± 0.048	2.502GluGln: 2.502 ± 0.038	3.314GluArg: 3.314 ± 0.049	4.757GluSer: 4.757 ± 0.058	3.617GluThr: 3.617 ± 0.044	3.644GluVal: 3.644 ± 0.052	0.537GluTrp: 0.537 ± 0.017	1.21GluTyr: 1.21 ± 0.033	0.0GluXaa: 0.0 ± 0.0
Phe	3.841PheAla: 3.841 ± 0.047	0.518PheCys: 0.518 ± 0.019	3.193PheAsp: 3.193 ± 0.05	2.048PheGlu: 2.048 ± 0.039	1.414PhePhe: 1.414 ± 0.033	3.367PheGly: 3.367 ± 0.048	0.816PheHis: 0.816 ± 0.022	1.408PheIle: 1.408 ± 0.031	0.844PheLys: 0.844 ± 0.025	3.194PheLeu: 3.194 ± 0.047	0.634PheMet: 0.634 ± 0.017	1.084PheAsn: 1.084 ± 0.027	1.563PhePro: 1.563 ± 0.029	1.405PheGln: 1.405 ± 0.025	2.413PheArg: 2.413 ± 0.036	2.124PheSer: 2.124 ± 0.037	1.898PheThr: 1.898 ± 0.042	2.829PheVal: 2.829 ± 0.041	0.533PheTrp: 0.533 ± 0.018	0.935PheTyr: 0.935 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	5.559GlyAla: 5.559 ± 0.073	1.097GlyCys: 1.097 ± 0.033	5.907GlyAsp: 5.907 ± 0.089	4.147GlyGlu: 4.147 ± 0.043	3.124GlyPhe: 3.124 ± 0.048	7.121GlyGly: 7.121 ± 0.149	1.828GlyHis: 1.828 ± 0.032	4.095GlyIle: 4.095 ± 0.052	3.142GlyLys: 3.142 ± 0.052	6.834GlyLeu: 6.834 ± 0.065	2.031GlyMet: 2.031 ± 0.035	2.758GlyAsn: 2.758 ± 0.058	3.443GlyPro: 3.443 ± 0.045	3.569GlyGln: 3.569 ± 0.042	5.633GlyArg: 5.633 ± 0.057	5.011GlySer: 5.011 ± 0.086	4.661GlyThr: 4.661 ± 0.1	5.591GlyVal: 5.591 ± 0.064	1.4GlyTrp: 1.4 ± 0.032	2.174GlyTyr: 2.174 ± 0.037	0.0GlyXaa: 0.0 ± 0.0
His	1.998HisAla: 1.998 ± 0.037	0.363HisCys: 0.363 ± 0.015	1.533HisAsp: 1.533 ± 0.032	1.108HisGlu: 1.108 ± 0.028	0.916HisPhe: 0.916 ± 0.023	1.828HisGly: 1.828 ± 0.035	0.783HisHis: 0.783 ± 0.026	0.776HisIle: 0.776 ± 0.022	0.458HisLys: 0.458 ± 0.016	2.218HisLeu: 2.218 ± 0.035	0.372HisMet: 0.372 ± 0.014	0.564HisAsn: 0.564 ± 0.017	1.544HisPro: 1.544 ± 0.035	1.072HisGln: 1.072 ± 0.029	1.923HisArg: 1.923 ± 0.034	1.25HisSer: 1.25 ± 0.027	0.96HisThr: 0.96 ± 0.021	1.584HisVal: 1.584 ± 0.033	0.525HisTrp: 0.525 ± 0.017	0.607HisTyr: 0.607 ± 0.017	0.0HisXaa: 0.0 ± 0.0
Ile	6.099IleAla: 6.099 ± 0.058	0.609IleCys: 0.609 ± 0.018	4.754IleAsp: 4.754 ± 0.057	3.423IleGlu: 3.423 ± 0.049	1.363IlePhe: 1.363 ± 0.03	4.449IleGly: 4.449 ± 0.052	1.17IleHis: 1.17 ± 0.024	1.791IleIle: 1.791 ± 0.037	1.284IleLys: 1.284 ± 0.028	3.65IleLeu: 3.65 ± 0.052	0.711IleMet: 0.711 ± 0.02	1.582IleAsn: 1.582 ± 0.034	2.429IlePro: 2.429 ± 0.039	1.968IleGln: 1.968 ± 0.036	4.052IleArg: 4.052 ± 0.049	2.744IleSer: 2.744 ± 0.037	2.625IleThr: 2.625 ± 0.056	3.864IleVal: 3.864 ± 0.045	0.569IleTrp: 0.569 ± 0.016	1.085IleTyr: 1.085 ± 0.023	0.001IleXaa: 0.001 ± 0.001
Lys	2.85LysAla: 2.85 ± 0.045	0.27LysCys: 0.27 ± 0.012	1.722LysAsp: 1.722 ± 0.033	1.519LysGlu: 1.519 ± 0.032	1.062LysPhe: 1.062 ± 0.025	1.829LysGly: 1.829 ± 0.033	0.794LysHis: 0.794 ± 0.024	1.683LysIle: 1.683 ± 0.035	1.342LysLys: 1.342 ± 0.035	3.039LysLeu: 3.039 ± 0.046	0.769LysMet: 0.769 ± 0.021	0.996LysAsn: 0.996 ± 0.028	1.969LysPro: 1.969 ± 0.036	1.483LysGln: 1.483 ± 0.032	2.428LysArg: 2.428 ± 0.037	2.084LysSer: 2.084 ± 0.043	1.979LysThr: 1.979 ± 0.032	2.21LysVal: 2.21 ± 0.042	0.457LysTrp: 0.457 ± 0.014	0.772LysTyr: 0.772 ± 0.022	0.0LysXaa: 0.0 ± 0.0
Leu	10.014LeuAla: 10.014 ± 0.082	1.124LeuCys: 1.124 ± 0.027	6.211LeuAsp: 6.211 ± 0.065	4.52LeuGlu: 4.52 ± 0.059	3.096LeuPhe: 3.096 ± 0.038	6.757LeuGly: 6.757 ± 0.071	1.938LeuHis: 1.938 ± 0.031	4.798LeuIle: 4.798 ± 0.056	3.021LeuLys: 3.021 ± 0.049	8.468LeuLeu: 8.468 ± 0.092	2.145LeuMet: 2.145 ± 0.037	2.731LeuAsn: 2.731 ± 0.043	5.082LeuPro: 5.082 ± 0.057	3.686LeuGln: 3.686 ± 0.044	6.563LeuArg: 6.563 ± 0.08	6.175LeuSer: 6.175 ± 0.057	5.248LeuThr: 5.248 ± 0.058	6.908LeuVal: 6.908 ± 0.067	1.24LeuTrp: 1.24 ± 0.026	1.953LeuTyr: 1.953 ± 0.033	0.001LeuXaa: 0.001 ± 0.001
Met	2.267MetAla: 2.267 ± 0.036	0.206MetCys: 0.206 ± 0.01	1.24MetAsp: 1.24 ± 0.026	0.99MetGlu: 0.99 ± 0.026	0.727MetPhe: 0.727 ± 0.017	1.547MetGly: 1.547 ± 0.03	0.511MetHis: 0.511 ± 0.016	1.351MetIle: 1.351 ± 0.026	0.974MetLys: 0.974 ± 0.024	2.345MetLeu: 2.345 ± 0.04	0.628MetMet: 0.628 ± 0.02	0.927MetAsn: 0.927 ± 0.022	1.531MetPro: 1.531 ± 0.028	1.003MetGln: 1.003 ± 0.023	1.588MetArg: 1.588 ± 0.032	1.526MetSer: 1.526 ± 0.027	1.66MetThr: 1.66 ± 0.028	1.684MetVal: 1.684 ± 0.034	0.265MetTrp: 0.265 ± 0.012	0.396MetTyr: 0.396 ± 0.014	0.0MetXaa: 0.0 ± 0.0
Asn	2.987AsnAla: 2.987 ± 0.049	0.323AsnCys: 0.323 ± 0.014	2.241AsnAsp: 2.241 ± 0.044	1.713AsnGlu: 1.713 ± 0.032	1.065AsnPhe: 1.065 ± 0.028	2.682AsnGly: 2.682 ± 0.06	0.821AsnHis: 0.821 ± 0.021	1.248AsnIle: 1.248 ± 0.026	0.701AsnLys: 0.701 ± 0.02	2.796AsnLeu: 2.796 ± 0.038	0.526AsnMet: 0.526 ± 0.015	0.951AsnAsn: 0.951 ± 0.03	1.976AsnPro: 1.976 ± 0.035	1.408AsnGln: 1.408 ± 0.031	2.447AsnArg: 2.447 ± 0.041	1.65AsnSer: 1.65 ± 0.034	1.521AsnThr: 1.521 ± 0.038	2.347AsnVal: 2.347 ± 0.04	0.464AsnTrp: 0.464 ± 0.016	0.753AsnTyr: 0.753 ± 0.018	0.0AsnXaa: 0.0 ± 0.0
Pro	5.274ProAla: 5.274 ± 0.063	0.394ProCys: 0.394 ± 0.015	4.218ProAsp: 4.218 ± 0.047	3.521ProGlu: 3.521 ± 0.044	1.755ProPhe: 1.755 ± 0.028	4.16ProGly: 4.16 ± 0.054	1.139ProHis: 1.139 ± 0.027	2.759ProIle: 2.759 ± 0.037	1.743ProLys: 1.743 ± 0.035	4.354ProLeu: 4.354 ± 0.05	1.349ProMet: 1.349 ± 0.029	1.835ProAsn: 1.835 ± 0.033	3.047ProPro: 3.047 ± 0.053	1.956ProGln: 1.956 ± 0.036	2.736ProArg: 2.736 ± 0.041	3.723ProSer: 3.723 ± 0.054	3.329ProThr: 3.329 ± 0.043	4.042ProVal: 4.042 ± 0.051	0.812ProTrp: 0.812 ± 0.02	1.1ProTyr: 1.1 ± 0.027	0.0ProXaa: 0.0 ± 0.0
Gln	3.98GlnAla: 3.98 ± 0.048	0.501GlnCys: 0.501 ± 0.017	2.041GlnAsp: 2.041 ± 0.033	1.646GlnGlu: 1.646 ± 0.034	1.513GlnPhe: 1.513 ± 0.028	2.39GlnGly: 2.39 ± 0.036	1.015GlnHis: 1.015 ± 0.025	2.436GlnIle: 2.436 ± 0.039	1.312GlnLys: 1.312 ± 0.028	4.107GlnLeu: 4.107 ± 0.045	1.082GlnMet: 1.082 ± 0.023	1.268GlnAsn: 1.268 ± 0.025	2.575GlnPro: 2.575 ± 0.044	2.363GlnGln: 2.363 ± 0.055	3.573GlnArg: 3.573 ± 0.059	3.107GlnSer: 3.107 ± 0.037	2.823GlnThr: 2.823 ± 0.042	2.77GlnVal: 2.77 ± 0.033	0.962GlnTrp: 0.962 ± 0.024	1.036GlnTyr: 1.036 ± 0.022	0.0GlnXaa: 0.0 ± 0.0
Arg	4.484ArgAla: 4.484 ± 0.054	0.985ArgCys: 0.985 ± 0.025	4.401ArgAsp: 4.401 ± 0.051	3.425ArgGlu: 3.425 ± 0.051	3.131ArgPhe: 3.131 ± 0.04	4.498ArgGly: 4.498 ± 0.046	1.733ArgHis: 1.733 ± 0.031	3.833ArgIle: 3.833 ± 0.043	2.175ArgLys: 2.175 ± 0.039	7.53ArgLeu: 7.53 ± 0.083	1.889ArgMet: 1.889 ± 0.032	2.035ArgAsn: 2.035 ± 0.034	3.802ArgPro: 3.802 ± 0.052	3.505ArgGln: 3.505 ± 0.056	6.4ArgArg: 6.4 ± 0.091	4.694ArgSer: 4.694 ± 0.058	3.348ArgThr: 3.348 ± 0.044	4.65ArgVal: 4.65 ± 0.054	1.535ArgTrp: 1.535 ± 0.039	1.983ArgTyr: 1.983 ± 0.041	0.0ArgXaa: 0.0 ± 0.0
Ser	5.952SerAla: 5.952 ± 0.068	0.636SerCys: 0.636 ± 0.02	5.087SerAsp: 5.087 ± 0.069	3.43SerGlu: 3.43 ± 0.047	2.255SerPhe: 2.255 ± 0.034	6.016SerGly: 6.016 ± 0.082	1.314SerHis: 1.314 ± 0.025	3.373SerIle: 3.373 ± 0.04	1.861SerLys: 1.861 ± 0.036	6.142SerLeu: 6.142 ± 0.049	1.613SerMet: 1.613 ± 0.03	1.948SerAsn: 1.948 ± 0.038	3.735SerPro: 3.735 ± 0.044	2.518SerGln: 2.518 ± 0.035	4.174SerArg: 4.174 ± 0.05	4.244SerSer: 4.244 ± 0.063	3.64SerThr: 3.64 ± 0.054	5.01SerVal: 5.01 ± 0.051	0.894SerTrp: 0.894 ± 0.021	1.294SerTyr: 1.294 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	5.615ThrAla: 5.615 ± 0.065	0.57ThrCys: 0.57 ± 0.018	4.093ThrAsp: 4.093 ± 0.055	3.004ThrGlu: 3.004 ± 0.042	2.043ThrPhe: 2.043 ± 0.043	4.912ThrGly: 4.912 ± 0.072	1.115ThrHis: 1.115 ± 0.025	3.216ThrIle: 3.216 ± 0.061	1.63ThrLys: 1.63 ± 0.033	5.619ThrLeu: 5.619 ± 0.061	1.294ThrMet: 1.294 ± 0.028	1.642ThrAsn: 1.642 ± 0.038	3.578ThrPro: 3.578 ± 0.048	1.854ThrGln: 1.854 ± 0.036	3.242ThrArg: 3.242 ± 0.04	3.528ThrSer: 3.528 ± 0.058	3.399ThrThr: 3.399 ± 0.065	4.511ThrVal: 4.511 ± 0.082	0.815ThrTrp: 0.815 ± 0.025	1.332ThrTyr: 1.332 ± 0.036	0.0ThrXaa: 0.0 ± 0.001
Val	7.783ValAla: 7.783 ± 0.076	0.997ValCys: 0.997 ± 0.023	5.718ValAsp: 5.718 ± 0.059	3.74ValGlu: 3.74 ± 0.052	2.648ValPhe: 2.648 ± 0.04	5.592ValGly: 5.592 ± 0.064	1.544ValHis: 1.544 ± 0.031	3.822ValIle: 3.822 ± 0.046	1.926ValLys: 1.926 ± 0.035	6.594ValLeu: 6.594 ± 0.067	1.75ValMet: 1.75 ± 0.035	2.129ValAsn: 2.129 ± 0.043	3.732ValPro: 3.732 ± 0.043	2.885ValGln: 2.885 ± 0.043	5.072ValArg: 5.072 ± 0.054	4.63ValSer: 4.63 ± 0.064	4.552ValThr: 4.552 ± 0.073	6.011ValVal: 6.011 ± 0.061	1.025ValTrp: 1.025 ± 0.027	1.646ValTyr: 1.646 ± 0.03	0.0ValXaa: 0.0 ± 0.0
Trp	1.161TrpAla: 1.161 ± 0.029	0.232TrpCys: 0.232 ± 0.011	0.94TrpAsp: 0.94 ± 0.021	0.631TrpGlu: 0.631 ± 0.019	0.624TrpPhe: 0.624 ± 0.02	0.958TrpGly: 0.958 ± 0.021	0.433TrpHis: 0.433 ± 0.016	0.947TrpIle: 0.947 ± 0.024	0.635TrpLys: 0.635 ± 0.019	1.677TrpLeu: 1.677 ± 0.038	0.514TrpMet: 0.514 ± 0.017	0.602TrpAsn: 0.602 ± 0.018	0.742TrpPro: 0.742 ± 0.025	0.799TrpGln: 0.799 ± 0.022	1.03TrpArg: 1.03 ± 0.023	1.004TrpSer: 1.004 ± 0.025	0.947TrpThr: 0.947 ± 0.023	0.996TrpVal: 0.996 ± 0.027	0.318TrpTrp: 0.318 ± 0.014	0.372TrpTyr: 0.372 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.064TyrAla: 2.064 ± 0.031	0.332TyrCys: 0.332 ± 0.013	1.683TyrAsp: 1.683 ± 0.037	1.348TyrGlu: 1.348 ± 0.029	1.011TyrPhe: 1.011 ± 0.022	1.945TyrGly: 1.945 ± 0.04	0.631TyrHis: 0.631 ± 0.021	0.755TyrIle: 0.755 ± 0.023	0.548TyrLys: 0.548 ± 0.019	2.242TyrLeu: 2.242 ± 0.035	0.369TyrMet: 0.369 ± 0.012	0.654TyrAsn: 0.654 ± 0.021	1.192TyrPro: 1.192 ± 0.027	1.245TyrGln: 1.245 ± 0.029	2.177TyrArg: 2.177 ± 0.036	1.256TyrSer: 1.256 ± 0.028	1.092TyrThr: 1.092 ± 0.031	1.6TyrVal: 1.6 ± 0.028	0.417TyrTrp: 0.417 ± 0.015	0.674TyrTyr: 0.674 ± 0.023	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.001XaaAsp: 0.001 ± 0.001	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.001	0.001XaaSer: 0.001 ± 0.001	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.001	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.001	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 5367 proteins (2083014 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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