Amino acid dipepetide frequency for SAR202 cluster bacterium AC-409-J13_OGT_754m

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.814AlaAla: 5.814 ± 0.215
0.893AlaCys: 0.893 ± 0.059
3.417AlaAsp: 3.417 ± 0.105
3.883AlaGlu: 3.883 ± 0.115
3.013AlaPhe: 3.013 ± 0.113
5.657AlaGly: 5.657 ± 0.175
1.559AlaHis: 1.559 ± 0.08
6.238AlaIle: 6.238 ± 0.145
3.704AlaLys: 3.704 ± 0.117
7.724AlaLeu: 7.724 ± 0.167
2.126AlaMet: 2.126 ± 0.096
3.081AlaAsn: 3.081 ± 0.102
2.377AlaPro: 2.377 ± 0.096
2.494AlaGln: 2.494 ± 0.092
3.476AlaArg: 3.476 ± 0.12
5.103AlaSer: 5.103 ± 0.136
4.249AlaThr: 4.249 ± 0.129
5.25AlaVal: 5.25 ± 0.162
0.835AlaTrp: 0.835 ± 0.045
2.139AlaTyr: 2.139 ± 0.068
0.0AlaXaa: 0.0 ± 0.0
Cys
0.597CysAla: 0.597 ± 0.046
0.127CysCys: 0.127 ± 0.022
0.528CysAsp: 0.528 ± 0.036
0.548CysGlu: 0.548 ± 0.038
0.375CysPhe: 0.375 ± 0.036
0.962CysGly: 0.962 ± 0.06
0.251CysHis: 0.251 ± 0.032
0.701CysIle: 0.701 ± 0.049
0.427CysLys: 0.427 ± 0.045
0.897CysLeu: 0.897 ± 0.055
0.222CysMet: 0.222 ± 0.026
0.45CysAsn: 0.45 ± 0.04
0.492CysPro: 0.492 ± 0.044
0.316CysGln: 0.316 ± 0.032
0.515CysArg: 0.515 ± 0.041
0.743CysSer: 0.743 ± 0.05
0.584CysThr: 0.584 ± 0.045
0.633CysVal: 0.633 ± 0.05
0.101CysTrp: 0.101 ± 0.017
0.251CysTyr: 0.251 ± 0.029
0.0CysXaa: 0.0 ± 0.0
Asp
3.453AspAla: 3.453 ± 0.114
0.528AspCys: 0.528 ± 0.046
2.582AspAsp: 2.582 ± 0.107
3.528AspGlu: 3.528 ± 0.114
2.263AspPhe: 2.263 ± 0.081
4.529AspGly: 4.529 ± 0.158
0.939AspHis: 0.939 ± 0.06
4.663AspIle: 4.663 ± 0.116
2.644AspLys: 2.644 ± 0.096
5.628AspLeu: 5.628 ± 0.14
1.565AspMet: 1.565 ± 0.07
2.155AspAsn: 2.155 ± 0.094
2.758AspPro: 2.758 ± 0.107
1.696AspGln: 1.696 ± 0.071
2.772AspArg: 2.772 ± 0.116
3.795AspSer: 3.795 ± 0.122
2.648AspThr: 2.648 ± 0.102
3.828AspVal: 3.828 ± 0.13
0.629AspTrp: 0.629 ± 0.044
1.777AspTyr: 1.777 ± 0.07
0.0AspXaa: 0.0 ± 0.0
Glu
4.637GluAla: 4.637 ± 0.138
0.447GluCys: 0.447 ± 0.043
3.029GluAsp: 3.029 ± 0.116
4.444GluGlu: 4.444 ± 0.13
2.318GluPhe: 2.318 ± 0.094
4.353GluGly: 4.353 ± 0.129
1.249GluHis: 1.249 ± 0.056
4.721GluIle: 4.721 ± 0.129
2.954GluLys: 2.954 ± 0.102
6.277GluLeu: 6.277 ± 0.159
1.764GluMet: 1.764 ± 0.082
2.488GluAsn: 2.488 ± 0.091
2.097GluPro: 2.097 ± 0.083
2.22GluGln: 2.22 ± 0.091
3.407GluArg: 3.407 ± 0.117
4.167GluSer: 4.167 ± 0.113
3.414GluThr: 3.414 ± 0.111
4.438GluVal: 4.438 ± 0.118
0.698GluTrp: 0.698 ± 0.053
1.81GluTyr: 1.81 ± 0.077
0.0GluXaa: 0.0 ± 0.0
Phe
2.788PheAla: 2.788 ± 0.11
0.437PheCys: 0.437 ± 0.038
2.393PheAsp: 2.393 ± 0.086
2.09PheGlu: 2.09 ± 0.074
1.519PhePhe: 1.519 ± 0.082
3.326PheGly: 3.326 ± 0.108
0.818PheHis: 0.818 ± 0.048
2.788PheIle: 2.788 ± 0.118
1.715PheLys: 1.715 ± 0.067
3.913PheLeu: 3.913 ± 0.146
1.069PheMet: 1.069 ± 0.068
1.767PheAsn: 1.767 ± 0.071
1.875PhePro: 1.875 ± 0.08
1.272PheGln: 1.272 ± 0.063
1.875PheArg: 1.875 ± 0.07
2.67PheSer: 2.67 ± 0.105
2.126PheThr: 2.126 ± 0.08
2.71PheVal: 2.71 ± 0.12
0.58PheTrp: 0.58 ± 0.053
1.262PheTyr: 1.262 ± 0.073
0.0PheXaa: 0.0 ± 0.0
Gly
5.625GlyAla: 5.625 ± 0.158
0.887GlyCys: 0.887 ± 0.062
4.027GlyAsp: 4.027 ± 0.128
4.033GlyGlu: 4.033 ± 0.126
3.698GlyPhe: 3.698 ± 0.125
5.986GlyGly: 5.986 ± 0.188
1.927GlyHis: 1.927 ± 0.081
6.564GlyIle: 6.564 ± 0.149
4.294GlyLys: 4.294 ± 0.132
8.063GlyLeu: 8.063 ± 0.191
2.25GlyMet: 2.25 ± 0.09
3.098GlyAsn: 3.098 ± 0.114
2.983GlyPro: 2.983 ± 0.106
2.52GlyGln: 2.52 ± 0.083
3.942GlyArg: 3.942 ± 0.11
5.595GlySer: 5.595 ± 0.134
4.444GlyThr: 4.444 ± 0.129
5.853GlyVal: 5.853 ± 0.155
1.144GlyTrp: 1.144 ± 0.076
2.533GlyTyr: 2.533 ± 0.087
0.0GlyXaa: 0.0 ± 0.0
His
1.36HisAla: 1.36 ± 0.068
0.248HisCys: 0.248 ± 0.031
0.972HisAsp: 0.972 ± 0.057
1.089HisGlu: 1.089 ± 0.058
0.753HisPhe: 0.753 ± 0.047
1.784HisGly: 1.784 ± 0.079
0.512HisHis: 0.512 ± 0.044
1.572HisIle: 1.572 ± 0.079
0.897HisLys: 0.897 ± 0.05
2.113HisLeu: 2.113 ± 0.086
0.528HisMet: 0.528 ± 0.041
0.858HisAsn: 0.858 ± 0.052
1.402HisPro: 1.402 ± 0.072
0.711HisGln: 0.711 ± 0.041
1.18HisArg: 1.18 ± 0.065
1.5HisSer: 1.5 ± 0.074
0.939HisThr: 0.939 ± 0.057
1.304HisVal: 1.304 ± 0.068
0.293HisTrp: 0.293 ± 0.034
0.652HisTyr: 0.652 ± 0.043
0.0HisXaa: 0.0 ± 0.0
Ile
6.12IleAla: 6.12 ± 0.13
0.783IleCys: 0.783 ± 0.05
4.689IleAsp: 4.689 ± 0.128
5.038IleGlu: 5.038 ± 0.134
2.788IlePhe: 2.788 ± 0.135
6.401IleGly: 6.401 ± 0.157
1.539IleHis: 1.539 ± 0.069
5.266IleIle: 5.266 ± 0.154
3.87IleLys: 3.87 ± 0.129
7.366IleLeu: 7.366 ± 0.189
1.79IleMet: 1.79 ± 0.079
3.411IleAsn: 3.411 ± 0.109
3.87IlePro: 3.87 ± 0.122
2.442IleGln: 2.442 ± 0.093
4.024IleArg: 4.024 ± 0.109
5.693IleSer: 5.693 ± 0.141
4.324IleThr: 4.324 ± 0.106
5.318IleVal: 5.318 ± 0.146
0.861IleTrp: 0.861 ± 0.049
2.018IleTyr: 2.018 ± 0.079
0.0IleXaa: 0.0 ± 0.0
Lys
3.857LysAla: 3.857 ± 0.134
0.421LysCys: 0.421 ± 0.039
2.85LysAsp: 2.85 ± 0.105
3.534LysGlu: 3.534 ± 0.109
1.497LysPhe: 1.497 ± 0.073
3.675LysGly: 3.675 ± 0.103
0.871LysHis: 0.871 ± 0.053
3.332LysIle: 3.332 ± 0.12
2.299LysLys: 2.299 ± 0.096
4.666LysLeu: 4.666 ± 0.132
1.242LysMet: 1.242 ± 0.063
2.07LysAsn: 2.07 ± 0.083
2.224LysPro: 2.224 ± 0.093
1.66LysGln: 1.66 ± 0.07
2.472LysArg: 2.472 ± 0.097
3.398LysSer: 3.398 ± 0.113
3.202LysThr: 3.202 ± 0.11
3.473LysVal: 3.473 ± 0.113
0.571LysTrp: 0.571 ± 0.048
1.601LysTyr: 1.601 ± 0.077
0.0LysXaa: 0.0 ± 0.0
Leu
7.868LeuAla: 7.868 ± 0.164
0.841LeuCys: 0.841 ± 0.057
5.726LeuAsp: 5.726 ± 0.143
6.303LeuGlu: 6.303 ± 0.161
3.623LeuPhe: 3.623 ± 0.129
8.112LeuGly: 8.112 ± 0.168
1.757LeuHis: 1.757 ± 0.07
7.424LeuIle: 7.424 ± 0.192
4.79LeuLys: 4.79 ± 0.147
9.583LeuLeu: 9.583 ± 0.235
2.608LeuMet: 2.608 ± 0.099
4.118LeuAsn: 4.118 ± 0.118
4.346LeuPro: 4.346 ± 0.13
2.938LeuGln: 2.938 ± 0.112
4.972LeuArg: 4.972 ± 0.133
7.718LeuSer: 7.718 ± 0.16
5.559LeuThr: 5.559 ± 0.117
7.258LeuVal: 7.258 ± 0.169
1.083LeuTrp: 1.083 ± 0.059
2.413LeuTyr: 2.413 ± 0.09
0.0LeuXaa: 0.0 ± 0.0
Met
2.462MetAla: 2.462 ± 0.089
0.205MetCys: 0.205 ± 0.028
1.699MetAsp: 1.699 ± 0.084
1.705MetGlu: 1.705 ± 0.075
0.942MetPhe: 0.942 ± 0.055
2.39MetGly: 2.39 ± 0.088
0.45MetHis: 0.45 ± 0.039
1.979MetIle: 1.979 ± 0.081
1.327MetLys: 1.327 ± 0.064
2.325MetLeu: 2.325 ± 0.099
0.678MetMet: 0.678 ± 0.055
1.187MetAsn: 1.187 ± 0.067
1.278MetPro: 1.278 ± 0.057
0.753MetGln: 0.753 ± 0.051
1.379MetArg: 1.379 ± 0.062
1.78MetSer: 1.78 ± 0.07
1.578MetThr: 1.578 ± 0.072
1.999MetVal: 1.999 ± 0.086
0.329MetTrp: 0.329 ± 0.036
0.571MetTyr: 0.571 ± 0.048
0.0MetXaa: 0.0 ± 0.0
Asn
2.889AsnAla: 2.889 ± 0.096
0.427AsnCys: 0.427 ± 0.044
2.198AsnAsp: 2.198 ± 0.101
2.155AsnGlu: 2.155 ± 0.076
1.36AsnPhe: 1.36 ± 0.065
3.003AsnGly: 3.003 ± 0.096
0.968AsnHis: 0.968 ± 0.053
3.384AsnIle: 3.384 ± 0.108
2.289AsnLys: 2.289 ± 0.09
4.47AsnLeu: 4.47 ± 0.13
1.314AsnMet: 1.314 ± 0.06
1.878AsnAsn: 1.878 ± 0.085
2.664AsnPro: 2.664 ± 0.094
1.611AsnGln: 1.611 ± 0.07
2.289AsnArg: 2.289 ± 0.084
3.026AsnSer: 3.026 ± 0.1
2.237AsnThr: 2.237 ± 0.096
2.889AsnVal: 2.889 ± 0.1
0.646AsnTrp: 0.646 ± 0.042
1.255AsnTyr: 1.255 ± 0.065
0.0AsnXaa: 0.0 ± 0.0
Pro
2.566ProAla: 2.566 ± 0.111
0.365ProCys: 0.365 ± 0.032
2.547ProAsp: 2.547 ± 0.092
2.811ProGlu: 2.811 ± 0.109
1.855ProPhe: 1.855 ± 0.077
3.567ProGly: 3.567 ± 0.113
1.063ProHis: 1.063 ± 0.062
3.583ProIle: 3.583 ± 0.123
2.201ProLys: 2.201 ± 0.089
4.04ProLeu: 4.04 ± 0.131
1.197ProMet: 1.197 ± 0.064
2.23ProAsn: 2.23 ± 0.098
1.829ProPro: 1.829 ± 0.099
1.327ProGln: 1.327 ± 0.074
1.901ProArg: 1.901 ± 0.081
3.362ProSer: 3.362 ± 0.112
2.801ProThr: 2.801 ± 0.121
3.052ProVal: 3.052 ± 0.102
0.61ProTrp: 0.61 ± 0.046
1.366ProTyr: 1.366 ± 0.077
0.0ProXaa: 0.0 ± 0.0
Gln
2.517GlnAla: 2.517 ± 0.108
0.339GlnCys: 0.339 ± 0.034
1.607GlnAsp: 1.607 ± 0.064
2.119GlnGlu: 2.119 ± 0.093
1.242GlnPhe: 1.242 ± 0.05
2.357GlnGly: 2.357 ± 0.086
0.737GlnHis: 0.737 ± 0.048
2.856GlnIle: 2.856 ± 0.092
1.425GlnLys: 1.425 ± 0.072
3.195GlnLeu: 3.195 ± 0.107
0.9GlnMet: 0.9 ± 0.063
1.392GlnAsn: 1.392 ± 0.072
1.321GlnPro: 1.321 ± 0.07
1.167GlnGln: 1.167 ± 0.07
1.8GlnArg: 1.8 ± 0.089
2.361GlnSer: 2.361 ± 0.099
1.8GlnThr: 1.8 ± 0.078
2.224GlnVal: 2.224 ± 0.08
0.388GlnTrp: 0.388 ± 0.035
0.897GlnTyr: 0.897 ± 0.045
0.0GlnXaa: 0.0 ± 0.0
Arg
3.309ArgAla: 3.309 ± 0.108
0.509ArgCys: 0.509 ± 0.044
2.55ArgAsp: 2.55 ± 0.096
3.339ArgGlu: 3.339 ± 0.121
2.139ArgPhe: 2.139 ± 0.077
3.557ArgGly: 3.557 ± 0.094
1.069ArgHis: 1.069 ± 0.053
4.265ArgIle: 4.265 ± 0.119
2.442ArgLys: 2.442 ± 0.094
5.302ArgLeu: 5.302 ± 0.137
1.503ArgMet: 1.503 ± 0.064
2.276ArgAsn: 2.276 ± 0.089
2.061ArgPro: 2.061 ± 0.082
1.813ArgGln: 1.813 ± 0.067
3.042ArgArg: 3.042 ± 0.128
3.388ArgSer: 3.388 ± 0.106
2.635ArgThr: 2.635 ± 0.093
3.557ArgVal: 3.557 ± 0.112
0.639ArgTrp: 0.639 ± 0.047
1.562ArgTyr: 1.562 ± 0.069
0.0ArgXaa: 0.0 ± 0.0
Ser
4.575SerAla: 4.575 ± 0.131
0.652SerCys: 0.652 ± 0.042
3.825SerAsp: 3.825 ± 0.116
4.304SerGlu: 4.304 ± 0.116
2.921SerPhe: 2.921 ± 0.109
5.866SerGly: 5.866 ± 0.153
1.526SerHis: 1.526 ± 0.067
5.667SerIle: 5.667 ± 0.137
3.87SerLys: 3.87 ± 0.119
7.193SerLeu: 7.193 ± 0.192
2.119SerMet: 2.119 ± 0.081
3.424SerAsn: 3.424 ± 0.109
3.349SerPro: 3.349 ± 0.108
2.445SerGln: 2.445 ± 0.094
3.551SerArg: 3.551 ± 0.112
5.175SerSer: 5.175 ± 0.132
3.73SerThr: 3.73 ± 0.112
4.751SerVal: 4.751 ± 0.116
0.841SerTrp: 0.841 ± 0.057
1.924SerTyr: 1.924 ± 0.077
0.0SerXaa: 0.0 ± 0.0
Thr
4.154ThrAla: 4.154 ± 0.15
0.473ThrCys: 0.473 ± 0.04
2.99ThrAsp: 2.99 ± 0.103
2.983ThrGlu: 2.983 ± 0.1
2.24ThrPhe: 2.24 ± 0.098
4.728ThrGly: 4.728 ± 0.124
1.236ThrHis: 1.236 ± 0.064
4.402ThrIle: 4.402 ± 0.14
2.494ThrLys: 2.494 ± 0.096
5.504ThrLeu: 5.504 ± 0.137
1.34ThrMet: 1.34 ± 0.067
2.485ThrAsn: 2.485 ± 0.101
2.667ThrPro: 2.667 ± 0.118
1.682ThrGln: 1.682 ± 0.077
2.749ThrArg: 2.749 ± 0.082
4.043ThrSer: 4.043 ± 0.124
3.486ThrThr: 3.486 ± 0.123
3.984ThrVal: 3.984 ± 0.129
0.724ThrTrp: 0.724 ± 0.057
1.588ThrTyr: 1.588 ± 0.069
0.0ThrXaa: 0.0 ± 0.0
Val
5.638ValAla: 5.638 ± 0.16
0.691ValCys: 0.691 ± 0.046
4.385ValAsp: 4.385 ± 0.122
4.65ValGlu: 4.65 ± 0.143
2.807ValPhe: 2.807 ± 0.093
5.889ValGly: 5.889 ± 0.151
1.294ValHis: 1.294 ± 0.073
5.338ValIle: 5.338 ± 0.13
3.192ValLys: 3.192 ± 0.106
6.723ValLeu: 6.723 ± 0.143
1.744ValMet: 1.744 ± 0.073
2.941ValAsn: 2.941 ± 0.093
2.899ValPro: 2.899 ± 0.09
1.956ValGln: 1.956 ± 0.08
3.326ValArg: 3.326 ± 0.116
5.197ValSer: 5.197 ± 0.147
4.17ValThr: 4.17 ± 0.138
5.664ValVal: 5.664 ± 0.133
0.701ValTrp: 0.701 ± 0.051
1.705ValTyr: 1.705 ± 0.079
0.0ValXaa: 0.0 ± 0.0
Trp
0.946TrpAla: 0.946 ± 0.062
0.098TrpCys: 0.098 ± 0.018
0.815TrpAsp: 0.815 ± 0.057
0.737TrpGlu: 0.737 ± 0.049
0.483TrpPhe: 0.483 ± 0.044
0.991TrpGly: 0.991 ± 0.056
0.264TrpHis: 0.264 ± 0.026
0.805TrpIle: 0.805 ± 0.055
0.691TrpLys: 0.691 ± 0.048
1.219TrpLeu: 1.219 ± 0.068
0.339TrpMet: 0.339 ± 0.031
0.528TrpAsn: 0.528 ± 0.04
0.404TrpPro: 0.404 ± 0.036
0.437TrpGln: 0.437 ± 0.041
0.587TrpArg: 0.587 ± 0.044
0.877TrpSer: 0.877 ± 0.052
0.668TrpThr: 0.668 ± 0.056
0.906TrpVal: 0.906 ± 0.055
0.215TrpTrp: 0.215 ± 0.027
0.349TrpTyr: 0.349 ± 0.034
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.859TyrAla: 1.859 ± 0.077
0.349TyrCys: 0.349 ± 0.033
1.552TyrAsp: 1.552 ± 0.073
1.637TyrGlu: 1.637 ± 0.06
1.158TyrPhe: 1.158 ± 0.068
2.335TyrGly: 2.335 ± 0.083
0.636TyrHis: 0.636 ± 0.045
2.061TyrIle: 2.061 ± 0.087
1.386TyrLys: 1.386 ± 0.072
2.84TyrLeu: 2.84 ± 0.111
0.714TyrMet: 0.714 ± 0.05
1.115TyrAsn: 1.115 ± 0.063
1.376TyrPro: 1.376 ± 0.07
1.184TyrGln: 1.184 ± 0.061
1.699TyrArg: 1.699 ± 0.076
2.119TyrSer: 2.119 ± 0.087
1.36TyrThr: 1.36 ± 0.07
1.823TyrVal: 1.823 ± 0.084
0.473TyrTrp: 0.473 ± 0.039
0.805TyrTyr: 0.805 ± 0.048
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 976 proteins (306694 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski