Amino acid dipepetide frequency for Hibiscus latent Singapore virus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
9.636AlaAla: 9.636 ± 1.614
2.487AlaCys: 2.487 ± 0.258
3.108AlaAsp: 3.108 ± 0.404
2.798AlaGlu: 2.798 ± 0.577
3.108AlaPhe: 3.108 ± 0.404
3.73AlaGly: 3.73 ± 0.589
0.0AlaHis: 0.0 ± 0.0
4.352AlaIle: 4.352 ± 0.183
5.284AlaLys: 5.284 ± 1.34
6.528AlaLeu: 6.528 ± 1.28
1.554AlaMet: 1.554 ± 0.502
4.663AlaAsn: 4.663 ± 0.227
0.622AlaPro: 0.622 ± 1.289
1.865AlaGln: 1.865 ± 0.253
3.73AlaArg: 3.73 ± 1.003
2.176AlaSer: 2.176 ± 0.338
4.041AlaThr: 4.041 ± 1.616
4.352AlaVal: 4.352 ± 0.689
0.622AlaTrp: 0.622 ± 0.167
2.176AlaTyr: 2.176 ± 0.533
0.0AlaXaa: 0.0 ± 0.0
Cys
2.176CysAla: 2.176 ± 0.533
1.243CysCys: 1.243 ± 0.334
1.243CysAsp: 1.243 ± 0.343
0.622CysGlu: 0.622 ± 0.167
0.622CysPhe: 0.622 ± 0.167
1.865CysGly: 1.865 ± 0.501
0.0CysHis: 0.0 ± 0.0
1.865CysIle: 1.865 ± 0.253
1.243CysLys: 1.243 ± 0.334
2.176CysLeu: 2.176 ± 0.533
0.933CysMet: 0.933 ± 0.25
0.933CysAsn: 0.933 ± 0.405
1.554CysPro: 1.554 ± 0.382
0.622CysGln: 0.622 ± 0.167
0.933CysArg: 0.933 ± 0.25
0.933CysSer: 0.933 ± 0.25
0.933CysThr: 0.933 ± 0.25
1.865CysVal: 1.865 ± 0.501
0.0CysTrp: 0.0 ± 0.0
1.243CysTyr: 1.243 ± 0.334
0.0CysXaa: 0.0 ± 0.0
Asp
2.176AspAla: 2.176 ± 1.135
3.108AspCys: 3.108 ± 0.353
1.243AspAsp: 1.243 ± 0.503
5.906AspGlu: 5.906 ± 0.967
4.041AspPhe: 4.041 ± 0.518
2.487AspGly: 2.487 ± 0.723
0.311AspHis: 0.311 ± 0.189
5.284AspIle: 5.284 ± 0.645
4.352AspLys: 4.352 ± 0.594
4.041AspLeu: 4.041 ± 0.946
0.933AspMet: 0.933 ± 0.25
3.108AspAsn: 3.108 ± 0.404
2.176AspPro: 2.176 ± 1.138
1.243AspGln: 1.243 ± 0.334
1.865AspArg: 1.865 ± 0.719
4.041AspSer: 4.041 ± 0.51
4.663AspThr: 4.663 ± 0.798
5.906AspVal: 5.906 ± 0.302
0.0AspTrp: 0.0 ± 0.0
2.798AspTyr: 2.798 ± 0.751
0.0AspXaa: 0.0 ± 0.0
Glu
5.906GluAla: 5.906 ± 0.99
0.0GluCys: 0.0 ± 0.0
1.243GluAsp: 1.243 ± 0.343
2.176GluGlu: 2.176 ± 1.027
3.108GluPhe: 3.108 ± 0.579
2.176GluGly: 2.176 ± 0.533
2.176GluHis: 2.176 ± 0.533
2.176GluIle: 2.176 ± 1.3
3.419GluLys: 3.419 ± 0.854
3.73GluLeu: 3.73 ± 0.912
1.865GluMet: 1.865 ± 0.501
4.663GluAsn: 4.663 ± 0.655
2.798GluPro: 2.798 ± 0.692
2.176GluGln: 2.176 ± 1.135
1.554GluArg: 1.554 ± 0.382
5.595GluSer: 5.595 ± 0.888
2.798GluThr: 2.798 ± 0.464
3.73GluVal: 3.73 ± 0.976
1.865GluTrp: 1.865 ± 0.501
3.419GluTyr: 3.419 ± 0.87
0.0GluXaa: 0.0 ± 0.0
Phe
1.554PheAla: 1.554 ± 0.476
1.865PheCys: 1.865 ± 0.771
3.73PheAsp: 3.73 ± 0.489
4.041PheGlu: 4.041 ± 0.859
3.108PhePhe: 3.108 ± 0.901
1.554PheGly: 1.554 ± 0.382
1.865PheHis: 1.865 ± 0.253
2.176PheIle: 2.176 ± 0.297
4.352PheLys: 4.352 ± 0.483
2.798PheLeu: 2.798 ± 0.451
1.243PheMet: 1.243 ± 0.334
1.243PheAsn: 1.243 ± 0.411
1.243PhePro: 1.243 ± 0.411
1.865PheGln: 1.865 ± 0.696
3.73PheArg: 3.73 ± 0.491
5.595PheSer: 5.595 ± 0.759
4.663PheThr: 4.663 ± 0.655
2.487PheVal: 2.487 ± 0.686
0.0PheTrp: 0.0 ± 0.0
1.243PheTyr: 1.243 ± 0.503
0.0PheXaa: 0.0 ± 0.0
Gly
6.217GlyAla: 6.217 ± 0.706
1.554GlyCys: 1.554 ± 0.382
2.176GlyAsp: 2.176 ± 0.297
2.176GlyGlu: 2.176 ± 0.338
2.176GlyPhe: 2.176 ± 1.135
4.663GlyGly: 4.663 ± 1.676
0.933GlyHis: 0.933 ± 0.25
0.933GlyIle: 0.933 ± 0.566
7.46GlyLys: 7.46 ± 0.977
4.352GlyLeu: 4.352 ± 0.668
0.933GlyMet: 0.933 ± 0.405
4.041GlyAsn: 4.041 ± 0.637
2.176GlyPro: 2.176 ± 0.533
0.622GlyGln: 0.622 ± 0.476
1.554GlyArg: 1.554 ± 1.276
2.487GlySer: 2.487 ± 0.258
3.108GlyThr: 3.108 ± 1.093
1.865GlyVal: 1.865 ± 0.253
1.243GlyTrp: 1.243 ± 0.334
0.933GlyTyr: 0.933 ± 0.25
0.0GlyXaa: 0.0 ± 0.0
His
0.933HisAla: 0.933 ± 0.25
1.243HisCys: 1.243 ± 0.334
0.622HisAsp: 0.622 ± 0.167
0.622HisGlu: 0.622 ± 0.167
0.933HisPhe: 0.933 ± 0.25
0.0HisGly: 0.0 ± 0.0
0.933HisHis: 0.933 ± 0.25
2.487HisIle: 2.487 ± 0.624
1.554HisLys: 1.554 ± 0.533
1.865HisLeu: 1.865 ± 0.81
0.933HisMet: 0.933 ± 0.25
0.311HisAsn: 0.311 ± 0.522
0.311HisPro: 0.311 ± 0.522
0.933HisGln: 0.933 ± 0.25
0.311HisArg: 0.311 ± 0.189
2.487HisSer: 2.487 ± 0.624
2.487HisThr: 2.487 ± 0.669
1.554HisVal: 1.554 ± 0.382
0.0HisTrp: 0.0 ± 0.0
0.0HisTyr: 0.0 ± 0.0
0.0HisXaa: 0.0 ± 0.0
Ile
2.798IleAla: 2.798 ± 0.299
2.176IleCys: 2.176 ± 0.338
4.041IleAsp: 4.041 ± 0.72
2.798IleGlu: 2.798 ± 1.003
1.554IlePhe: 1.554 ± 0.588
3.108IleGly: 3.108 ± 0.579
0.933IleHis: 0.933 ± 0.639
3.73IleIle: 3.73 ± 0.849
4.663IleLys: 4.663 ± 0.719
2.798IleLeu: 2.798 ± 1.573
0.311IleMet: 0.311 ± 0.522
1.865IleAsn: 1.865 ± 0.431
2.798IlePro: 2.798 ± 0.417
1.865IleGln: 1.865 ± 0.501
1.865IleArg: 1.865 ± 0.501
5.284IleSer: 5.284 ± 0.526
5.595IleThr: 5.595 ± 0.957
2.487IleVal: 2.487 ± 0.559
0.622IleTrp: 0.622 ± 0.378
0.622IleTyr: 0.622 ± 0.613
0.0IleXaa: 0.0 ± 0.0
Lys
5.906LysAla: 5.906 ± 0.967
0.0LysCys: 0.0 ± 0.0
2.487LysAsp: 2.487 ± 1.239
5.595LysGlu: 5.595 ± 0.977
3.73LysPhe: 3.73 ± 0.491
6.528LysGly: 6.528 ± 1.09
1.554LysHis: 1.554 ± 0.588
2.487LysIle: 2.487 ± 0.669
6.528LysLys: 6.528 ± 1.65
6.217LysLeu: 6.217 ± 0.667
0.622LysMet: 0.622 ± 1.044
4.352LysAsn: 4.352 ± 0.183
1.554LysPro: 1.554 ± 0.382
2.487LysGln: 2.487 ± 0.624
5.595LysArg: 5.595 ± 0.957
4.663LysSer: 4.663 ± 0.922
4.352LysThr: 4.352 ± 0.903
6.528LysVal: 6.528 ± 1.304
0.933LysTrp: 0.933 ± 0.405
1.865LysTyr: 1.865 ± 0.488
0.0LysXaa: 0.0 ± 0.0
Leu
4.974LeuAla: 4.974 ± 1.021
1.554LeuCys: 1.554 ± 0.382
7.771LeuAsp: 7.771 ± 0.772
3.419LeuGlu: 3.419 ± 0.951
2.487LeuPhe: 2.487 ± 0.428
4.041LeuGly: 4.041 ± 0.299
2.798LeuHis: 2.798 ± 0.417
3.73LeuIle: 3.73 ± 0.986
5.906LeuLys: 5.906 ± 0.774
8.393LeuLeu: 8.393 ± 3.156
3.73LeuMet: 3.73 ± 0.489
4.663LeuAsn: 4.663 ± 2.196
2.176LeuPro: 2.176 ± 0.297
4.663LeuGln: 4.663 ± 0.846
3.73LeuArg: 3.73 ± 1.852
7.46LeuSer: 7.46 ± 0.252
5.595LeuThr: 5.595 ± 0.908
9.015LeuVal: 9.015 ± 1.776
1.243LeuTrp: 1.243 ± 0.334
4.974LeuTyr: 4.974 ± 1.247
0.0LeuXaa: 0.0 ± 0.0
Met
0.311MetAla: 0.311 ± 0.522
0.0MetCys: 0.0 ± 0.0
1.243MetAsp: 1.243 ± 0.343
1.243MetGlu: 1.243 ± 0.334
1.554MetPhe: 1.554 ± 0.333
0.622MetGly: 0.622 ± 0.167
0.0MetHis: 0.0 ± 0.0
1.865MetIle: 1.865 ± 0.253
3.108MetLys: 3.108 ± 0.667
1.554MetLeu: 1.554 ± 0.382
0.0MetMet: 0.0 ± 0.0
1.243MetAsn: 1.243 ± 0.334
1.554MetPro: 1.554 ± 0.476
1.554MetGln: 1.554 ± 0.333
0.622MetArg: 0.622 ± 0.378
0.933MetSer: 0.933 ± 0.405
1.243MetThr: 1.243 ± 0.334
1.554MetVal: 1.554 ± 0.333
0.311MetTrp: 0.311 ± 0.189
1.243MetTyr: 1.243 ± 0.334
0.0MetXaa: 0.0 ± 0.0
Asn
3.73AsnAla: 3.73 ± 0.589
0.311AsnCys: 0.311 ± 0.189
3.73AsnAsp: 3.73 ± 0.912
1.243AsnGlu: 1.243 ± 0.334
3.108AsnPhe: 3.108 ± 0.901
1.243AsnGly: 1.243 ± 0.343
0.622AsnHis: 0.622 ± 0.167
3.419AsnIle: 3.419 ± 0.351
0.933AsnLys: 0.933 ± 0.566
4.352AsnLeu: 4.352 ± 2.827
1.554AsnMet: 1.554 ± 0.333
2.487AsnAsn: 2.487 ± 0.258
2.798AsnPro: 2.798 ± 0.464
1.865AsnGln: 1.865 ± 0.501
2.487AsnArg: 2.487 ± 0.417
3.419AsnSer: 3.419 ± 1.46
1.865AsnThr: 1.865 ± 0.719
6.528AsnVal: 6.528 ± 1.128
0.0AsnTrp: 0.0 ± 0.0
2.176AsnTyr: 2.176 ± 0.338
0.0AsnXaa: 0.0 ± 0.0
Pro
0.933ProAla: 0.933 ± 0.25
0.933ProCys: 0.933 ± 0.25
2.487ProAsp: 2.487 ± 0.624
2.487ProGlu: 2.487 ± 0.669
2.487ProPhe: 2.487 ± 0.669
2.176ProGly: 2.176 ± 0.654
0.622ProHis: 0.622 ± 0.167
1.865ProIle: 1.865 ± 0.253
4.663ProLys: 4.663 ± 1.145
5.906ProLeu: 5.906 ± 0.656
0.622ProMet: 0.622 ± 0.881
1.554ProAsn: 1.554 ± 0.333
1.243ProPro: 1.243 ± 0.334
1.243ProGln: 1.243 ± 0.343
0.311ProArg: 0.311 ± 0.189
1.243ProSer: 1.243 ± 0.343
3.73ProThr: 3.73 ± 1.479
2.176ProVal: 2.176 ± 0.465
0.311ProTrp: 0.311 ± 0.522
1.865ProTyr: 1.865 ± 1.082
0.0ProXaa: 0.0 ± 0.0
Gln
3.73GlnAla: 3.73 ± 0.266
1.243GlnCys: 1.243 ± 0.334
4.041GlnAsp: 4.041 ± 0.678
0.933GlnGlu: 0.933 ± 0.25
0.622GlnPhe: 0.622 ± 0.167
3.419GlnGly: 3.419 ± 0.882
0.933GlnHis: 0.933 ± 0.25
1.865GlnIle: 1.865 ± 0.696
1.243GlnLys: 1.243 ± 0.343
3.108GlnLeu: 3.108 ± 0.404
1.243GlnMet: 1.243 ± 0.334
0.933GlnAsn: 0.933 ± 0.25
1.865GlnPro: 1.865 ± 0.501
4.974GlnGln: 4.974 ± 0.722
1.865GlnArg: 1.865 ± 0.431
1.865GlnSer: 1.865 ± 0.813
3.108GlnThr: 3.108 ± 0.467
0.933GlnVal: 0.933 ± 0.25
0.0GlnTrp: 0.0 ± 0.0
1.243GlnTyr: 1.243 ± 0.334
0.0GlnXaa: 0.0 ± 0.0
Arg
1.243ArgAla: 1.243 ± 0.829
1.243ArgCys: 1.243 ± 0.411
2.487ArgAsp: 2.487 ± 0.581
2.487ArgGlu: 2.487 ± 0.417
2.798ArgPhe: 2.798 ± 0.417
1.554ArgGly: 1.554 ± 0.333
0.622ArgHis: 0.622 ± 0.167
1.865ArgIle: 1.865 ± 0.719
3.419ArgLys: 3.419 ± 0.87
4.974ArgLeu: 4.974 ± 0.572
0.311ArgMet: 0.311 ± 0.522
2.176ArgAsn: 2.176 ± 0.465
2.798ArgPro: 2.798 ± 0.511
0.622ArgGln: 0.622 ± 0.167
2.176ArgArg: 2.176 ± 0.338
4.041ArgSer: 4.041 ± 0.295
2.487ArgThr: 2.487 ± 0.417
4.041ArgVal: 4.041 ± 0.589
0.0ArgTrp: 0.0 ± 0.0
1.554ArgTyr: 1.554 ± 0.476
0.0ArgXaa: 0.0 ± 0.0
Ser
2.176SerAla: 2.176 ± 0.338
0.622SerCys: 0.622 ± 0.167
3.108SerAsp: 3.108 ± 1.319
6.217SerGlu: 6.217 ± 0.706
3.73SerPhe: 3.73 ± 0.564
2.798SerGly: 2.798 ± 2.615
0.622SerHis: 0.622 ± 0.167
3.73SerIle: 3.73 ± 0.658
3.73SerLys: 3.73 ± 1.233
8.393SerLeu: 8.393 ± 0.866
0.933SerMet: 0.933 ± 0.255
4.663SerAsn: 4.663 ± 0.326
2.176SerPro: 2.176 ± 0.533
1.243SerGln: 1.243 ± 0.343
3.108SerArg: 3.108 ± 1.093
2.798SerSer: 2.798 ± 0.299
3.73SerThr: 3.73 ± 0.46
5.906SerVal: 5.906 ± 0.76
0.311SerTrp: 0.311 ± 0.644
5.906SerTyr: 5.906 ± 0.774
0.0SerXaa: 0.0 ± 0.0
Thr
3.73ThrAla: 3.73 ± 1.479
1.243ThrCys: 1.243 ± 0.334
4.041ThrAsp: 4.041 ± 1.252
3.419ThrGlu: 3.419 ± 0.537
3.419ThrPhe: 3.419 ± 0.497
2.487ThrGly: 2.487 ± 0.624
1.243ThrHis: 1.243 ± 0.334
2.798ThrIle: 2.798 ± 0.751
2.487ThrLys: 2.487 ± 0.417
10.569ThrLeu: 10.569 ± 0.79
1.243ThrMet: 1.243 ± 0.33
2.798ThrAsn: 2.798 ± 0.696
4.352ThrPro: 4.352 ± 0.183
4.663ThrGln: 4.663 ± 0.862
3.419ThrArg: 3.419 ± 0.497
3.419ThrSer: 3.419 ± 1.428
4.974ThrThr: 4.974 ± 2.841
7.15ThrVal: 7.15 ± 1.166
0.0ThrTrp: 0.0 ± 0.0
3.108ThrTyr: 3.108 ± 0.836
0.0ThrXaa: 0.0 ± 0.0
Val
5.284ValAla: 5.284 ± 1.471
1.554ValCys: 1.554 ± 0.382
4.974ValAsp: 4.974 ± 0.375
6.839ValGlu: 6.839 ± 0.787
4.041ValPhe: 4.041 ± 1.289
3.73ValGly: 3.73 ± 0.651
3.419ValHis: 3.419 ± 0.537
3.419ValIle: 3.419 ± 0.561
5.595ValLys: 5.595 ± 0.356
6.528ValLeu: 6.528 ± 1.6
1.243ValMet: 1.243 ± 0.334
1.865ValAsn: 1.865 ± 0.253
2.487ValPro: 2.487 ± 0.258
3.108ValGln: 3.108 ± 0.353
3.419ValArg: 3.419 ± 0.602
4.974ValSer: 4.974 ± 0.229
4.974ValThr: 4.974 ± 0.797
3.419ValVal: 3.419 ± 1.39
1.865ValTrp: 1.865 ± 0.431
2.798ValTyr: 2.798 ± 0.451
0.0ValXaa: 0.0 ± 0.0
Trp
0.311TrpAla: 0.311 ± 0.644
0.0TrpCys: 0.0 ± 0.0
1.865TrpAsp: 1.865 ± 0.501
0.933TrpGlu: 0.933 ± 0.503
1.865TrpPhe: 1.865 ± 0.501
0.622TrpGly: 0.622 ± 0.167
0.311TrpHis: 0.311 ± 0.522
0.622TrpIle: 0.622 ± 0.167
0.311TrpLys: 0.311 ± 0.189
0.0TrpLeu: 0.0 ± 0.0
0.0TrpMet: 0.0 ± 0.0
0.311TrpAsn: 0.311 ± 0.189
0.0TrpPro: 0.0 ± 0.0
0.0TrpGln: 0.0 ± 0.0
0.0TrpArg: 0.0 ± 0.0
0.622TrpSer: 0.622 ± 0.167
0.622TrpThr: 0.622 ± 0.167
1.554TrpVal: 1.554 ± 0.476
0.0TrpTrp: 0.0 ± 0.0
0.311TrpTyr: 0.311 ± 0.189
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.108TyrAla: 3.108 ± 0.353
0.622TyrCys: 0.622 ± 0.167
4.041TyrAsp: 4.041 ± 1.068
0.622TyrGlu: 0.622 ± 0.167
1.865TyrPhe: 1.865 ± 0.771
2.798TyrGly: 2.798 ± 0.692
0.622TyrHis: 0.622 ± 0.378
1.243TyrIle: 1.243 ± 0.411
3.73TyrLys: 3.73 ± 0.489
4.041TyrLeu: 4.041 ± 0.72
1.243TyrMet: 1.243 ± 0.334
0.0TyrAsn: 0.0 ± 0.0
2.176TyrPro: 2.176 ± 0.465
1.554TyrGln: 1.554 ± 0.382
0.622TyrArg: 0.622 ± 0.167
1.865TyrSer: 1.865 ± 0.253
5.906TyrThr: 5.906 ± 0.56
2.487TyrVal: 2.487 ± 0.581
0.933TyrTrp: 0.933 ± 0.25
0.933TyrTyr: 0.933 ± 0.25
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4 proteins (3218 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski