Amino acid dipepetide frequency for Hubei virga-like virus 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.314AlaAla: 11.314 ± 5.036
2.031AlaCys: 2.031 ± 1.096
5.222AlaAsp: 5.222 ± 2.002
6.092AlaGlu: 6.092 ± 2.336
3.481AlaPhe: 3.481 ± 2.415
8.413AlaGly: 8.413 ± 3.225
4.062AlaHis: 4.062 ± 0.318
6.092AlaIle: 6.092 ± 0.461
4.642AlaLys: 4.642 ± 0.095
9.574AlaLeu: 9.574 ± 1.796
1.741AlaMet: 1.741 ± 1.207
3.191AlaAsn: 3.191 ± 0.651
6.092AlaPro: 6.092 ± 0.461
2.031AlaGln: 2.031 ± 1.096
4.352AlaArg: 4.352 ± 3.956
11.894AlaSer: 11.894 ± 2.685
3.771AlaThr: 3.771 ± 2.303
8.413AlaVal: 8.413 ± 0.524
0.29AlaTrp: 0.29 ± 0.111
2.901AlaTyr: 2.901 ± 1.112
0.0AlaXaa: 0.0 ± 0.0
Cys
1.741CysAla: 1.741 ± 0.667
0.58CysCys: 0.58 ± 0.222
1.741CysAsp: 1.741 ± 1.207
0.29CysGlu: 0.29 ± 0.111
0.0CysPhe: 0.0 ± 0.0
1.16CysGly: 1.16 ± 0.445
0.29CysHis: 0.29 ± 0.111
0.29CysIle: 0.29 ± 0.111
2.031CysLys: 2.031 ± 0.779
2.321CysLeu: 2.321 ± 0.89
0.0CysMet: 0.0 ± 0.0
0.58CysAsn: 0.58 ± 1.652
1.451CysPro: 1.451 ± 0.556
1.16CysGln: 1.16 ± 1.43
0.58CysArg: 0.58 ± 0.222
0.58CysSer: 0.58 ± 1.652
1.451CysThr: 1.451 ± 0.556
2.031CysVal: 2.031 ± 0.779
0.0CysTrp: 0.0 ± 0.0
0.58CysTyr: 0.58 ± 0.222
0.0CysXaa: 0.0 ± 0.0
Asp
6.672AspAla: 6.672 ± 1.191
0.58AspCys: 0.58 ± 0.222
4.062AspAsp: 4.062 ± 2.192
2.031AspGlu: 2.031 ± 0.779
3.191AspPhe: 3.191 ± 2.526
2.611AspGly: 2.611 ± 1.001
0.58AspHis: 0.58 ± 0.222
2.611AspIle: 2.611 ± 1.001
2.031AspLys: 2.031 ± 0.779
4.932AspLeu: 4.932 ± 5.608
0.87AspMet: 0.87 ± 0.334
0.29AspAsn: 0.29 ± 0.111
4.932AspPro: 4.932 ± 1.891
1.451AspGln: 1.451 ± 1.319
4.352AspArg: 4.352 ± 0.206
2.901AspSer: 2.901 ± 1.112
3.771AspThr: 3.771 ± 1.446
8.703AspVal: 8.703 ± 2.287
0.58AspTrp: 0.58 ± 0.222
0.87AspTyr: 0.87 ± 0.334
0.0AspXaa: 0.0 ± 0.0
Glu
5.802GluAla: 5.802 ± 1.525
1.16GluCys: 1.16 ± 0.445
1.451GluAsp: 1.451 ± 1.319
1.451GluGlu: 1.451 ± 0.556
1.741GluPhe: 1.741 ± 1.207
2.321GluGly: 2.321 ± 0.985
1.16GluHis: 1.16 ± 0.445
1.741GluIle: 1.741 ± 0.667
1.741GluLys: 1.741 ± 0.667
4.932GluLeu: 4.932 ± 1.891
1.741GluMet: 1.741 ± 0.667
1.741GluAsn: 1.741 ± 0.667
1.451GluPro: 1.451 ± 0.556
0.58GluGln: 0.58 ± 0.222
3.481GluArg: 3.481 ± 0.54
4.062GluSer: 4.062 ± 0.318
3.481GluThr: 3.481 ± 0.54
4.062GluVal: 4.062 ± 0.318
1.16GluTrp: 1.16 ± 1.43
3.191GluTyr: 3.191 ± 1.223
0.0GluXaa: 0.0 ± 0.0
Phe
2.321PheAla: 2.321 ± 0.985
0.58PheCys: 0.58 ± 0.222
2.611PheAsp: 2.611 ± 0.874
2.611PheGlu: 2.611 ± 2.748
0.58PhePhe: 0.58 ± 0.222
0.29PheGly: 0.29 ± 0.111
1.16PheHis: 1.16 ± 1.43
1.451PheIle: 1.451 ± 0.556
0.87PheLys: 0.87 ± 0.334
2.321PheLeu: 2.321 ± 0.89
0.29PheMet: 0.29 ± 0.111
2.611PheAsn: 2.611 ± 1.001
1.741PhePro: 1.741 ± 3.082
0.58PheGln: 0.58 ± 0.222
0.58PheArg: 0.58 ± 0.222
3.481PheSer: 3.481 ± 4.289
2.321PheThr: 2.321 ± 0.985
5.512PheVal: 5.512 ± 1.636
0.58PheTrp: 0.58 ± 0.222
0.87PheTyr: 0.87 ± 1.541
0.0PheXaa: 0.0 ± 0.0
Gly
5.802GlyAla: 5.802 ± 2.224
1.451GlyCys: 1.451 ± 0.556
3.771GlyAsp: 3.771 ± 1.446
2.321GlyGlu: 2.321 ± 0.89
1.741GlyPhe: 1.741 ± 1.207
2.901GlyGly: 2.901 ± 1.112
0.29GlyHis: 0.29 ± 0.111
0.58GlyIle: 0.58 ± 0.222
3.481GlyLys: 3.481 ± 1.335
4.642GlyLeu: 4.642 ± 0.095
1.16GlyMet: 1.16 ± 0.445
2.321GlyAsn: 2.321 ± 2.86
1.451GlyPro: 1.451 ± 0.556
1.16GlyGln: 1.16 ± 0.445
3.481GlyArg: 3.481 ± 1.335
4.932GlySer: 4.932 ± 1.859
4.352GlyThr: 4.352 ± 1.668
5.512GlyVal: 5.512 ± 0.238
0.29GlyTrp: 0.29 ± 0.111
2.611GlyTyr: 2.611 ± 1.001
0.0GlyXaa: 0.0 ± 0.0
His
2.901HisAla: 2.901 ± 2.637
0.29HisCys: 0.29 ± 0.111
2.031HisAsp: 2.031 ± 0.779
0.58HisGlu: 0.58 ± 0.222
0.58HisPhe: 0.58 ± 0.222
1.16HisGly: 1.16 ± 0.445
1.16HisHis: 1.16 ± 0.445
0.29HisIle: 0.29 ± 0.111
1.741HisLys: 1.741 ± 3.082
2.611HisLeu: 2.611 ± 1.001
1.451HisMet: 1.451 ± 0.506
0.58HisAsn: 0.58 ± 0.222
0.87HisPro: 0.87 ± 1.541
1.16HisGln: 1.16 ± 1.43
1.451HisArg: 1.451 ± 1.319
1.16HisSer: 1.16 ± 0.445
2.611HisThr: 2.611 ± 0.874
3.191HisVal: 3.191 ± 1.223
0.0HisTrp: 0.0 ± 0.0
0.29HisTyr: 0.29 ± 0.111
0.0HisXaa: 0.0 ± 0.0
Ile
3.481IleAla: 3.481 ± 0.54
0.29IleCys: 0.29 ± 0.111
2.031IleAsp: 2.031 ± 1.096
1.741IleGlu: 1.741 ± 0.667
0.87IlePhe: 0.87 ± 0.334
2.321IleGly: 2.321 ± 0.89
1.16IleHis: 1.16 ± 0.445
2.031IleIle: 2.031 ± 0.779
1.741IleLys: 1.741 ± 0.667
2.321IleLeu: 2.321 ± 0.89
0.58IleMet: 0.58 ± 0.222
1.741IleAsn: 1.741 ± 0.667
2.031IlePro: 2.031 ± 0.779
0.29IleGln: 0.29 ± 0.111
2.031IleArg: 2.031 ± 1.096
2.611IleSer: 2.611 ± 1.001
2.901IleThr: 2.901 ± 1.112
1.16IleVal: 1.16 ± 0.445
0.58IleTrp: 0.58 ± 0.222
2.031IleTyr: 2.031 ± 0.779
0.0IleXaa: 0.0 ± 0.0
Lys
5.222LysAla: 5.222 ± 2.002
0.87LysCys: 0.87 ± 0.334
1.741LysAsp: 1.741 ± 0.667
1.741LysGlu: 1.741 ± 0.667
2.611LysPhe: 2.611 ± 1.001
2.321LysGly: 2.321 ± 0.89
0.58LysHis: 0.58 ± 0.222
0.87LysIle: 0.87 ± 1.541
3.771LysLys: 3.771 ± 1.446
6.092LysLeu: 6.092 ± 2.336
0.87LysMet: 0.87 ± 1.541
1.451LysAsn: 1.451 ± 0.556
2.031LysPro: 2.031 ± 0.779
1.451LysGln: 1.451 ± 0.556
4.642LysArg: 4.642 ± 0.095
2.901LysSer: 2.901 ± 1.112
4.352LysThr: 4.352 ± 1.668
1.741LysVal: 1.741 ± 0.667
0.29LysTrp: 0.29 ± 1.763
2.611LysTyr: 2.611 ± 1.001
0.0LysXaa: 0.0 ± 0.0
Leu
7.253LeuAla: 7.253 ± 2.78
2.901LeuCys: 2.901 ± 0.762
4.932LeuAsp: 4.932 ± 0.016
4.932LeuGlu: 4.932 ± 1.859
4.062LeuPhe: 4.062 ± 0.318
4.932LeuGly: 4.932 ± 1.891
3.191LeuHis: 3.191 ± 2.526
3.191LeuIle: 3.191 ± 1.223
3.191LeuLys: 3.191 ± 1.223
8.413LeuLeu: 8.413 ± 1.351
1.741LeuMet: 1.741 ± 0.667
2.321LeuAsn: 2.321 ± 0.985
6.092LeuPro: 6.092 ± 0.461
3.191LeuGln: 3.191 ± 1.223
6.092LeuArg: 6.092 ± 1.414
5.222LeuSer: 5.222 ± 0.127
6.963LeuThr: 6.963 ± 0.795
6.382LeuVal: 6.382 ± 0.572
0.87LeuTrp: 0.87 ± 0.334
2.321LeuTyr: 2.321 ± 0.89
0.0LeuXaa: 0.0 ± 0.0
Met
2.321MetAla: 2.321 ± 0.89
0.58MetCys: 0.58 ± 0.222
0.87MetAsp: 0.87 ± 0.334
1.451MetGlu: 1.451 ± 0.556
1.16MetPhe: 1.16 ± 1.43
0.58MetGly: 0.58 ± 0.222
0.0MetHis: 0.0 ± 0.0
0.87MetIle: 0.87 ± 0.334
0.29MetLys: 0.29 ± 0.111
1.451MetLeu: 1.451 ± 0.556
0.87MetMet: 0.87 ± 0.334
1.741MetAsn: 1.741 ± 1.207
0.87MetPro: 0.87 ± 0.334
1.451MetGln: 1.451 ± 1.319
1.16MetArg: 1.16 ± 0.445
2.031MetSer: 2.031 ± 0.779
1.451MetThr: 1.451 ± 0.556
0.87MetVal: 0.87 ± 0.334
0.0MetTrp: 0.0 ± 0.0
0.87MetTyr: 0.87 ± 0.334
0.0MetXaa: 0.0 ± 0.0
Asn
4.642AsnAla: 4.642 ± 0.095
0.87AsnCys: 0.87 ± 0.334
2.321AsnAsp: 2.321 ± 2.86
0.58AsnGlu: 0.58 ± 0.222
1.451AsnPhe: 1.451 ± 3.193
2.901AsnGly: 2.901 ± 2.637
0.58AsnHis: 0.58 ± 0.222
0.58AsnIle: 0.58 ± 0.222
1.451AsnLys: 1.451 ± 0.556
2.901AsnLeu: 2.901 ± 1.112
0.29AsnMet: 0.29 ± 0.772
0.87AsnAsn: 0.87 ± 1.541
2.031AsnPro: 2.031 ± 1.096
0.87AsnGln: 0.87 ± 0.334
0.87AsnArg: 0.87 ± 0.334
2.321AsnSer: 2.321 ± 0.89
3.481AsnThr: 3.481 ± 0.54
2.321AsnVal: 2.321 ± 2.86
0.29AsnTrp: 0.29 ± 1.763
1.451AsnTyr: 1.451 ± 0.556
0.0AsnXaa: 0.0 ± 0.0
Pro
8.993ProAla: 8.993 ± 2.176
0.58ProCys: 0.58 ± 0.222
2.901ProAsp: 2.901 ± 1.112
4.352ProGlu: 4.352 ± 2.081
0.87ProPhe: 0.87 ± 1.541
2.901ProGly: 2.901 ± 1.112
1.16ProHis: 1.16 ± 0.445
1.451ProIle: 1.451 ± 0.556
2.611ProLys: 2.611 ± 1.001
3.771ProLeu: 3.771 ± 0.429
1.16ProMet: 1.16 ± 0.445
2.901ProAsn: 2.901 ± 2.637
4.932ProPro: 4.932 ± 0.016
0.87ProGln: 0.87 ± 0.334
3.481ProArg: 3.481 ± 1.335
6.382ProSer: 6.382 ± 1.303
4.352ProThr: 4.352 ± 1.668
2.611ProVal: 2.611 ± 1.001
0.87ProTrp: 0.87 ± 0.334
2.031ProTyr: 2.031 ± 1.096
0.0ProXaa: 0.0 ± 0.0
Gln
2.321GlnAla: 2.321 ± 0.985
0.58GlnCys: 0.58 ± 0.222
0.58GlnAsp: 0.58 ± 0.222
2.031GlnGlu: 2.031 ± 0.779
0.87GlnPhe: 0.87 ± 0.334
0.58GlnGly: 0.58 ± 0.222
0.87GlnHis: 0.87 ± 1.541
2.321GlnIle: 2.321 ± 0.89
1.741GlnLys: 1.741 ± 0.667
2.321GlnLeu: 2.321 ± 0.985
0.29GlnMet: 0.29 ± 0.111
0.0GlnAsn: 0.0 ± 0.0
3.771GlnPro: 3.771 ± 0.429
1.741GlnGln: 1.741 ± 0.667
1.451GlnArg: 1.451 ± 0.556
1.451GlnSer: 1.451 ± 0.556
1.451GlnThr: 1.451 ± 0.556
1.741GlnVal: 1.741 ± 0.667
0.0GlnTrp: 0.0 ± 0.0
1.16GlnTyr: 1.16 ± 1.43
0.0GlnXaa: 0.0 ± 0.0
Arg
5.512ArgAla: 5.512 ± 1.636
1.16ArgCys: 1.16 ± 0.445
2.901ArgAsp: 2.901 ± 0.762
2.031ArgGlu: 2.031 ± 1.096
1.16ArgPhe: 1.16 ± 1.43
2.611ArgGly: 2.611 ± 1.001
2.321ArgHis: 2.321 ± 0.985
1.451ArgIle: 1.451 ± 0.556
2.321ArgLys: 2.321 ± 0.89
6.672ArgLeu: 6.672 ± 0.683
0.29ArgMet: 0.29 ± 0.111
2.321ArgAsn: 2.321 ± 0.985
4.352ArgPro: 4.352 ± 0.206
0.87ArgGln: 0.87 ± 0.334
4.352ArgArg: 4.352 ± 0.206
4.062ArgSer: 4.062 ± 0.318
5.802ArgThr: 5.802 ± 3.4
5.512ArgVal: 5.512 ± 0.238
0.58ArgTrp: 0.58 ± 0.222
2.031ArgTyr: 2.031 ± 1.096
0.0ArgXaa: 0.0 ± 0.0
Ser
9.574SerAla: 9.574 ± 3.67
1.451SerCys: 1.451 ± 0.556
5.512SerAsp: 5.512 ± 0.238
4.062SerGlu: 4.062 ± 1.557
2.611SerPhe: 2.611 ± 1.001
4.062SerGly: 4.062 ± 0.318
0.87SerHis: 0.87 ± 0.334
2.901SerIle: 2.901 ± 1.112
4.642SerLys: 4.642 ± 1.779
6.672SerLeu: 6.672 ± 3.066
0.87SerMet: 0.87 ± 0.334
1.741SerAsn: 1.741 ± 0.667
4.352SerPro: 4.352 ± 3.956
4.062SerGln: 4.062 ± 1.557
6.382SerArg: 6.382 ± 3.177
8.123SerSer: 8.123 ± 3.114
7.833SerThr: 7.833 ± 1.128
5.512SerVal: 5.512 ± 0.238
1.451SerTrp: 1.451 ± 0.556
0.87SerTyr: 0.87 ± 0.334
0.0SerXaa: 0.0 ± 0.0
Thr
6.672ThrAla: 6.672 ± 1.191
0.58ThrCys: 0.58 ± 1.652
3.771ThrAsp: 3.771 ± 1.446
3.481ThrGlu: 3.481 ± 0.54
3.481ThrPhe: 3.481 ± 0.54
4.642ThrGly: 4.642 ± 1.779
2.031ThrHis: 2.031 ± 2.971
2.321ThrIle: 2.321 ± 0.89
5.222ThrLys: 5.222 ± 0.127
6.092ThrLeu: 6.092 ± 0.461
2.031ThrMet: 2.031 ± 0.779
2.321ThrAsn: 2.321 ± 0.985
6.092ThrPro: 6.092 ± 2.336
1.16ThrGln: 1.16 ± 0.445
3.481ThrArg: 3.481 ± 0.54
7.253ThrSer: 7.253 ± 0.906
6.672ThrThr: 6.672 ± 2.558
6.092ThrVal: 6.092 ± 2.336
1.451ThrTrp: 1.451 ± 0.556
3.481ThrTyr: 3.481 ± 1.335
0.0ThrXaa: 0.0 ± 0.0
Val
9.283ValAla: 9.283 ± 0.19
1.741ValCys: 1.741 ± 0.667
5.222ValAsp: 5.222 ± 5.497
4.062ValGlu: 4.062 ± 2.192
1.741ValPhe: 1.741 ± 1.207
4.642ValGly: 4.642 ± 0.095
2.901ValHis: 2.901 ± 1.112
1.451ValIle: 1.451 ± 0.556
2.901ValLys: 2.901 ± 1.112
6.672ValLeu: 6.672 ± 0.683
2.611ValMet: 2.611 ± 1.001
2.031ValAsn: 2.031 ± 2.971
2.611ValPro: 2.611 ± 0.874
2.031ValGln: 2.031 ± 0.779
3.481ValArg: 3.481 ± 1.335
8.413ValSer: 8.413 ± 3.225
6.963ValThr: 6.963 ± 2.669
6.672ValVal: 6.672 ± 1.191
1.16ValTrp: 1.16 ± 1.43
3.191ValTyr: 3.191 ± 1.223
0.0ValXaa: 0.0 ± 0.0
Trp
0.87TrpAla: 0.87 ± 0.334
0.29TrpCys: 0.29 ± 1.763
0.87TrpAsp: 0.87 ± 0.334
0.58TrpGlu: 0.58 ± 0.222
0.0TrpPhe: 0.0 ± 0.0
0.87TrpGly: 0.87 ± 1.541
0.29TrpHis: 0.29 ± 0.111
0.58TrpIle: 0.58 ± 0.222
0.87TrpLys: 0.87 ± 0.334
0.58TrpLeu: 0.58 ± 0.222
0.58TrpMet: 0.58 ± 0.222
1.16TrpAsn: 1.16 ± 1.43
0.0TrpPro: 0.0 ± 0.0
0.58TrpGln: 0.58 ± 0.222
0.58TrpArg: 0.58 ± 0.222
0.29TrpSer: 0.29 ± 0.111
1.451TrpThr: 1.451 ± 1.319
0.0TrpVal: 0.0 ± 0.0
0.0TrpTrp: 0.0 ± 0.0
0.0TrpTyr: 0.0 ± 0.0
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.901TyrAla: 2.901 ± 1.112
0.29TyrCys: 0.29 ± 0.111
3.481TyrAsp: 3.481 ± 1.335
2.031TyrGlu: 2.031 ± 0.779
1.16TyrPhe: 1.16 ± 0.445
2.031TyrGly: 2.031 ± 1.096
1.451TyrHis: 1.451 ± 0.556
0.87TyrIle: 0.87 ± 1.541
0.87TyrLys: 0.87 ± 0.334
2.901TyrLeu: 2.901 ± 1.112
1.16TyrMet: 1.16 ± 0.445
1.451TyrAsn: 1.451 ± 0.556
2.031TyrPro: 2.031 ± 0.779
0.58TyrGln: 0.58 ± 0.222
2.031TyrArg: 2.031 ± 1.096
3.481TyrSer: 3.481 ± 1.335
2.901TyrThr: 2.901 ± 1.112
1.741TyrVal: 1.741 ± 1.207
0.0TyrTrp: 0.0 ± 0.0
0.87TyrTyr: 0.87 ± 0.334
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2 proteins (3448 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski