Amino acid dipepetide frequency for Bifidobacterium felsineum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
13.95AlaAla: 13.95 ± 0.216
0.999AlaCys: 0.999 ± 0.042
7.191AlaAsp: 7.191 ± 0.126
6.353AlaGlu: 6.353 ± 0.127
3.529AlaPhe: 3.529 ± 0.07
8.767AlaGly: 8.767 ± 0.128
2.19AlaHis: 2.19 ± 0.059
6.185AlaIle: 6.185 ± 0.112
5.21AlaLys: 5.21 ± 0.091
10.491AlaLeu: 10.491 ± 0.133
3.1AlaMet: 3.1 ± 0.063
3.938AlaAsn: 3.938 ± 0.083
4.07AlaPro: 4.07 ± 0.093
4.523AlaGln: 4.523 ± 0.106
5.428AlaArg: 5.428 ± 0.103
6.499AlaSer: 6.499 ± 0.104
5.988AlaThr: 5.988 ± 0.114
8.35AlaVal: 8.35 ± 0.134
1.374AlaTrp: 1.374 ± 0.042
2.689AlaTyr: 2.689 ± 0.048
0.0AlaXaa: 0.0 ± 0.0
Cys
1.026CysAla: 1.026 ± 0.043
0.105CysCys: 0.105 ± 0.013
0.502CysAsp: 0.502 ± 0.03
0.475CysGlu: 0.475 ± 0.024
0.331CysPhe: 0.331 ± 0.021
0.907CysGly: 0.907 ± 0.04
0.201CysHis: 0.201 ± 0.016
0.456CysIle: 0.456 ± 0.024
0.251CysLys: 0.251 ± 0.021
0.719CysLeu: 0.719 ± 0.036
0.219CysMet: 0.219 ± 0.02
0.252CysAsn: 0.252 ± 0.019
0.423CysPro: 0.423 ± 0.026
0.227CysGln: 0.227 ± 0.019
0.449CysArg: 0.449 ± 0.023
0.503CysSer: 0.503 ± 0.029
0.513CysThr: 0.513 ± 0.029
0.688CysVal: 0.688 ± 0.032
0.144CysTrp: 0.144 ± 0.018
0.214CysTyr: 0.214 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
6.987AspAla: 6.987 ± 0.131
0.519AspCys: 0.519 ± 0.029
4.285AspAsp: 4.285 ± 0.095
4.421AspGlu: 4.421 ± 0.091
2.377AspPhe: 2.377 ± 0.057
5.421AspGly: 5.421 ± 0.103
1.264AspHis: 1.264 ± 0.047
3.384AspIle: 3.384 ± 0.079
2.574AspLys: 2.574 ± 0.068
5.128AspLeu: 5.128 ± 0.103
1.563AspMet: 1.563 ± 0.045
1.925AspAsn: 1.925 ± 0.061
3.241AspPro: 3.241 ± 0.068
1.961AspGln: 1.961 ± 0.058
2.899AspArg: 2.899 ± 0.076
3.666AspSer: 3.666 ± 0.085
3.276AspThr: 3.276 ± 0.079
4.806AspVal: 4.806 ± 0.088
1.056AspTrp: 1.056 ± 0.037
2.005AspTyr: 2.005 ± 0.054
0.0AspXaa: 0.0 ± 0.0
Glu
6.384GluAla: 6.384 ± 0.131
0.435GluCys: 0.435 ± 0.025
3.164GluAsp: 3.164 ± 0.082
3.387GluGlu: 3.387 ± 0.087
1.923GluPhe: 1.923 ± 0.055
3.846GluGly: 3.846 ± 0.092
1.853GluHis: 1.853 ± 0.053
2.909GluIle: 2.909 ± 0.069
2.208GluLys: 2.208 ± 0.069
5.332GluLeu: 5.332 ± 0.1
1.346GluMet: 1.346 ± 0.048
2.018GluAsn: 2.018 ± 0.053
2.619GluPro: 2.619 ± 0.072
2.734GluGln: 2.734 ± 0.075
3.768GluArg: 3.768 ± 0.092
3.346GluSer: 3.346 ± 0.067
3.25GluThr: 3.25 ± 0.068
3.69GluVal: 3.69 ± 0.077
0.698GluTrp: 0.698 ± 0.027
1.774GluTyr: 1.774 ± 0.054
0.0GluXaa: 0.0 ± 0.0
Phe
4.185PheAla: 4.185 ± 0.088
0.351PheCys: 0.351 ± 0.028
2.66PheAsp: 2.66 ± 0.065
1.865PheGlu: 1.865 ± 0.056
1.314PhePhe: 1.314 ± 0.054
3.479PheGly: 3.479 ± 0.08
0.76PheHis: 0.76 ± 0.037
1.907PheIle: 1.907 ± 0.065
1.312PheLys: 1.312 ± 0.044
2.829PheLeu: 2.829 ± 0.075
0.806PheMet: 0.806 ± 0.035
1.394PheAsn: 1.394 ± 0.048
1.46PhePro: 1.46 ± 0.048
1.06PheGln: 1.06 ± 0.039
1.53PheArg: 1.53 ± 0.047
2.221PheSer: 2.221 ± 0.059
2.474PheThr: 2.474 ± 0.073
2.782PheVal: 2.782 ± 0.069
0.534PheTrp: 0.534 ± 0.034
1.016PheTyr: 1.016 ± 0.042
0.0PheXaa: 0.0 ± 0.0
Gly
7.276GlyAla: 7.276 ± 0.125
0.735GlyCys: 0.735 ± 0.034
4.303GlyAsp: 4.303 ± 0.077
4.568GlyGlu: 4.568 ± 0.083
3.303GlyPhe: 3.303 ± 0.081
5.854GlyGly: 5.854 ± 0.112
1.716GlyHis: 1.716 ± 0.053
4.883GlyIle: 4.883 ± 0.101
4.158GlyLys: 4.158 ± 0.091
7.285GlyLeu: 7.285 ± 0.119
2.05GlyMet: 2.05 ± 0.06
2.778GlyAsn: 2.778 ± 0.09
2.517GlyPro: 2.517 ± 0.066
2.7GlyGln: 2.7 ± 0.068
3.997GlyArg: 3.997 ± 0.082
5.332GlySer: 5.332 ± 0.102
5.172GlyThr: 5.172 ± 0.104
6.169GlyVal: 6.169 ± 0.096
1.267GlyTrp: 1.267 ± 0.046
2.715GlyTyr: 2.715 ± 0.062
0.0GlyXaa: 0.0 ± 0.0
His
2.209HisAla: 2.209 ± 0.065
0.225HisCys: 0.225 ± 0.016
1.541HisAsp: 1.541 ± 0.043
1.231HisGlu: 1.231 ± 0.044
0.688HisPhe: 0.688 ± 0.029
1.941HisGly: 1.941 ± 0.062
0.582HisHis: 0.582 ± 0.032
1.261HisIle: 1.261 ± 0.041
0.745HisLys: 0.745 ± 0.031
1.61HisLeu: 1.61 ± 0.056
0.618HisMet: 0.618 ± 0.028
0.755HisAsn: 0.755 ± 0.035
1.298HisPro: 1.298 ± 0.044
0.697HisGln: 0.697 ± 0.031
1.279HisArg: 1.279 ± 0.045
1.069HisSer: 1.069 ± 0.038
1.285HisThr: 1.285 ± 0.046
1.868HisVal: 1.868 ± 0.056
0.37HisTrp: 0.37 ± 0.026
0.644HisTyr: 0.644 ± 0.028
0.0HisXaa: 0.0 ± 0.0
Ile
7.155IleAla: 7.155 ± 0.112
0.631IleCys: 0.631 ± 0.027
4.078IleAsp: 4.078 ± 0.074
3.31IleGlu: 3.31 ± 0.08
1.729IlePhe: 1.729 ± 0.061
4.904IleGly: 4.904 ± 0.108
1.057IleHis: 1.057 ± 0.039
3.311IleIle: 3.311 ± 0.088
2.028IleLys: 2.028 ± 0.061
4.08IleLeu: 4.08 ± 0.1
1.273IleMet: 1.273 ± 0.041
2.152IleAsn: 2.152 ± 0.06
2.763IlePro: 2.763 ± 0.067
1.426IleGln: 1.426 ± 0.042
2.849IleArg: 2.849 ± 0.068
3.348IleSer: 3.348 ± 0.074
3.699IleThr: 3.699 ± 0.083
4.92IleVal: 4.92 ± 0.101
0.637IleTrp: 0.637 ± 0.033
1.295IleTyr: 1.295 ± 0.043
0.0IleXaa: 0.0 ± 0.0
Lys
5.202LysAla: 5.202 ± 0.097
0.2LysCys: 0.2 ± 0.017
2.732LysAsp: 2.732 ± 0.085
2.266LysGlu: 2.266 ± 0.059
1.204LysPhe: 1.204 ± 0.039
2.814LysGly: 2.814 ± 0.072
1.019LysHis: 1.019 ± 0.035
2.053LysIle: 2.053 ± 0.06
2.002LysLys: 2.002 ± 0.068
3.636LysLeu: 3.636 ± 0.072
0.973LysMet: 0.973 ± 0.038
1.655LysAsn: 1.655 ± 0.056
2.531LysPro: 2.531 ± 0.07
1.614LysGln: 1.614 ± 0.058
2.444LysArg: 2.444 ± 0.074
2.39LysSer: 2.39 ± 0.061
2.748LysThr: 2.748 ± 0.075
3.063LysVal: 3.063 ± 0.077
0.491LysTrp: 0.491 ± 0.029
1.241LysTyr: 1.241 ± 0.045
0.0LysXaa: 0.0 ± 0.0
Leu
10.323LeuAla: 10.323 ± 0.117
0.865LeuCys: 0.865 ± 0.032
5.77LeuAsp: 5.77 ± 0.102
4.529LeuGlu: 4.529 ± 0.091
3.322LeuPhe: 3.322 ± 0.087
7.038LeuGly: 7.038 ± 0.103
1.801LeuHis: 1.801 ± 0.048
5.239LeuIle: 5.239 ± 0.107
4.023LeuLys: 4.023 ± 0.074
7.792LeuLeu: 7.792 ± 0.134
2.269LeuMet: 2.269 ± 0.064
3.308LeuAsn: 3.308 ± 0.07
4.551LeuPro: 4.551 ± 0.083
2.506LeuGln: 2.506 ± 0.063
4.428LeuArg: 4.428 ± 0.083
5.367LeuSer: 5.367 ± 0.092
5.892LeuThr: 5.892 ± 0.108
6.365LeuVal: 6.365 ± 0.115
1.035LeuTrp: 1.035 ± 0.042
2.124LeuTyr: 2.124 ± 0.061
0.0LeuXaa: 0.0 ± 0.0
Met
2.923MetAla: 2.923 ± 0.071
0.227MetCys: 0.227 ± 0.016
1.306MetAsp: 1.306 ± 0.042
1.06MetGlu: 1.06 ± 0.04
0.853MetPhe: 0.853 ± 0.036
1.843MetGly: 1.843 ± 0.06
0.566MetHis: 0.566 ± 0.032
1.391MetIle: 1.391 ± 0.044
1.053MetLys: 1.053 ± 0.035
2.445MetLeu: 2.445 ± 0.06
0.745MetMet: 0.745 ± 0.037
0.999MetAsn: 0.999 ± 0.036
1.432MetPro: 1.432 ± 0.046
0.803MetGln: 0.803 ± 0.033
1.512MetArg: 1.512 ± 0.052
1.811MetSer: 1.811 ± 0.053
1.877MetThr: 1.877 ± 0.054
1.824MetVal: 1.824 ± 0.054
0.264MetTrp: 0.264 ± 0.019
0.544MetTyr: 0.544 ± 0.027
0.0MetXaa: 0.0 ± 0.0
Asn
4.135AsnAla: 4.135 ± 0.075
0.229AsnCys: 0.229 ± 0.017
2.19AsnAsp: 2.19 ± 0.065
2.005AsnGlu: 2.005 ± 0.058
1.053AsnPhe: 1.053 ± 0.035
3.483AsnGly: 3.483 ± 0.084
0.774AsnHis: 0.774 ± 0.032
1.866AsnIle: 1.866 ± 0.053
1.425AsnLys: 1.425 ± 0.053
2.894AsnLeu: 2.894 ± 0.071
0.821AsnMet: 0.821 ± 0.036
1.433AsnAsn: 1.433 ± 0.058
2.377AsnPro: 2.377 ± 0.067
1.289AsnGln: 1.289 ± 0.052
1.976AsnArg: 1.976 ± 0.056
1.922AsnSer: 1.922 ± 0.064
2.346AsnThr: 2.346 ± 0.079
2.617AsnVal: 2.617 ± 0.053
0.497AsnTrp: 0.497 ± 0.029
1.045AsnTyr: 1.045 ± 0.043
0.0AsnXaa: 0.0 ± 0.0
Pro
4.847ProAla: 4.847 ± 0.105
0.271ProCys: 0.271 ± 0.02
3.139ProAsp: 3.139 ± 0.07
3.393ProGlu: 3.393 ± 0.075
1.731ProPhe: 1.731 ± 0.049
3.416ProGly: 3.416 ± 0.071
0.952ProHis: 0.952 ± 0.041
2.455ProIle: 2.455 ± 0.063
1.894ProLys: 1.894 ± 0.056
3.95ProLeu: 3.95 ± 0.077
1.089ProMet: 1.089 ± 0.039
1.76ProAsn: 1.76 ± 0.051
1.078ProPro: 1.078 ± 0.039
1.881ProGln: 1.881 ± 0.066
2.049ProArg: 2.049 ± 0.055
2.811ProSer: 2.811 ± 0.057
2.858ProThr: 2.858 ± 0.064
3.829ProVal: 3.829 ± 0.076
0.716ProTrp: 0.716 ± 0.036
1.436ProTyr: 1.436 ± 0.047
0.0ProXaa: 0.0 ± 0.0
Gln
3.844GlnAla: 3.844 ± 0.084
0.309GlnCys: 0.309 ± 0.021
1.636GlnAsp: 1.636 ± 0.049
1.627GlnGlu: 1.627 ± 0.054
1.25GlnPhe: 1.25 ± 0.045
2.353GlnGly: 2.353 ± 0.056
0.897GlnHis: 0.897 ± 0.033
1.968GlnIle: 1.968 ± 0.061
1.187GlnLys: 1.187 ± 0.045
3.441GlnLeu: 3.441 ± 0.083
1.026GlnMet: 1.026 ± 0.044
1.096GlnAsn: 1.096 ± 0.042
1.751GlnPro: 1.751 ± 0.067
1.815GlnGln: 1.815 ± 0.073
2.149GlnArg: 2.149 ± 0.07
2.361GlnSer: 2.361 ± 0.068
2.065GlnThr: 2.065 ± 0.054
2.66GlnVal: 2.66 ± 0.058
0.599GlnTrp: 0.599 ± 0.032
1.188GlnTyr: 1.188 ± 0.056
0.0GlnXaa: 0.0 ± 0.0
Arg
4.715ArgAla: 4.715 ± 0.109
0.386ArgCys: 0.386 ± 0.024
2.975ArgAsp: 2.975 ± 0.072
3.46ArgGlu: 3.46 ± 0.078
2.183ArgPhe: 2.183 ± 0.063
3.364ArgGly: 3.364 ± 0.081
1.322ArgHis: 1.322 ± 0.049
3.38ArgIle: 3.38 ± 0.076
2.506ArgLys: 2.506 ± 0.064
4.732ArgLeu: 4.732 ± 0.103
1.572ArgMet: 1.572 ± 0.052
1.976ArgAsn: 1.976 ± 0.056
2.164ArgPro: 2.164 ± 0.066
1.949ArgGln: 1.949 ± 0.056
3.708ArgArg: 3.708 ± 0.115
2.786ArgSer: 2.786 ± 0.063
2.956ArgThr: 2.956 ± 0.077
3.809ArgVal: 3.809 ± 0.097
0.802ArgTrp: 0.802 ± 0.034
1.713ArgTyr: 1.713 ± 0.054
0.0ArgXaa: 0.0 ± 0.0
Ser
6.408SerAla: 6.408 ± 0.113
0.453SerCys: 0.453 ± 0.028
3.879SerAsp: 3.879 ± 0.084
3.203SerGlu: 3.203 ± 0.074
2.202SerPhe: 2.202 ± 0.065
5.442SerGly: 5.442 ± 0.105
1.305SerHis: 1.305 ± 0.045
3.431SerIle: 3.431 ± 0.074
2.471SerLys: 2.471 ± 0.057
5.347SerLeu: 5.347 ± 0.097
1.616SerMet: 1.616 ± 0.049
2.313SerAsn: 2.313 ± 0.07
2.361SerPro: 2.361 ± 0.053
2.186SerGln: 2.186 ± 0.062
3.004SerArg: 3.004 ± 0.067
4.287SerSer: 4.287 ± 0.116
3.976SerThr: 3.976 ± 0.086
4.559SerVal: 4.559 ± 0.083
0.844SerTrp: 0.844 ± 0.034
1.632SerTyr: 1.632 ± 0.055
0.0SerXaa: 0.0 ± 0.0
Thr
6.487ThrAla: 6.487 ± 0.106
0.43ThrCys: 0.43 ± 0.024
3.772ThrAsp: 3.772 ± 0.081
2.945ThrGlu: 2.945 ± 0.067
2.304ThrPhe: 2.304 ± 0.07
5.274ThrGly: 5.274 ± 0.091
1.238ThrHis: 1.238 ± 0.045
3.81ThrIle: 3.81 ± 0.083
2.385ThrLys: 2.385 ± 0.081
5.796ThrLeu: 5.796 ± 0.099
1.441ThrMet: 1.441 ± 0.048
2.203ThrAsn: 2.203 ± 0.069
3.256ThrPro: 3.256 ± 0.073
2.038ThrGln: 2.038 ± 0.071
2.708ThrArg: 2.708 ± 0.066
3.618ThrSer: 3.618 ± 0.088
3.763ThrThr: 3.763 ± 0.1
5.784ThrVal: 5.784 ± 0.133
0.885ThrTrp: 0.885 ± 0.039
1.74ThrTyr: 1.74 ± 0.07
0.0ThrXaa: 0.0 ± 0.0
Val
8.451ValAla: 8.451 ± 0.115
0.76ValCys: 0.76 ± 0.035
4.908ValAsp: 4.908 ± 0.096
4.336ValGlu: 4.336 ± 0.084
3.039ValPhe: 3.039 ± 0.074
5.007ValGly: 5.007 ± 0.103
1.521ValHis: 1.521 ± 0.051
4.685ValIle: 4.685 ± 0.098
3.238ValLys: 3.238 ± 0.087
7.11ValLeu: 7.11 ± 0.091
1.97ValMet: 1.97 ± 0.059
2.783ValAsn: 2.783 ± 0.073
3.839ValPro: 3.839 ± 0.068
2.146ValGln: 2.146 ± 0.059
3.839ValArg: 3.839 ± 0.064
5.067ValSer: 5.067 ± 0.096
5.226ValThr: 5.226 ± 0.115
6.22ValVal: 6.22 ± 0.131
0.967ValTrp: 0.967 ± 0.037
1.881ValTyr: 1.881 ± 0.059
0.0ValXaa: 0.0 ± 0.0
Trp
1.187TrpAla: 1.187 ± 0.042
0.156TrpCys: 0.156 ± 0.015
0.789TrpAsp: 0.789 ± 0.036
0.577TrpGlu: 0.577 ± 0.029
0.595TrpPhe: 0.595 ± 0.03
0.924TrpGly: 0.924 ± 0.041
0.357TrpHis: 0.357 ± 0.025
0.776TrpIle: 0.776 ± 0.037
0.608TrpLys: 0.608 ± 0.032
1.493TrpLeu: 1.493 ± 0.049
0.4TrpMet: 0.4 ± 0.023
0.663TrpAsn: 0.663 ± 0.035
0.523TrpPro: 0.523 ± 0.028
0.647TrpGln: 0.647 ± 0.029
0.892TrpArg: 0.892 ± 0.041
0.873TrpSer: 0.873 ± 0.035
0.821TrpThr: 0.821 ± 0.033
0.932TrpVal: 0.932 ± 0.038
0.274TrpTrp: 0.274 ± 0.022
0.43TrpTyr: 0.43 ± 0.025
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.129TyrAla: 3.129 ± 0.067
0.321TyrCys: 0.321 ± 0.024
1.938TyrAsp: 1.938 ± 0.053
1.672TyrGlu: 1.672 ± 0.056
1.01TyrPhe: 1.01 ± 0.04
2.699TyrGly: 2.699 ± 0.07
0.539TyrHis: 0.539 ± 0.029
1.293TyrIle: 1.293 ± 0.042
1.002TyrLys: 1.002 ± 0.04
2.438TyrLeu: 2.438 ± 0.062
0.582TyrMet: 0.582 ± 0.03
0.975TyrAsn: 0.975 ± 0.042
1.304TyrPro: 1.304 ± 0.052
1.018TyrGln: 1.018 ± 0.044
1.551TyrArg: 1.551 ± 0.052
1.642TyrSer: 1.642 ± 0.048
1.691TyrThr: 1.691 ± 0.063
2.057TyrVal: 2.057 ± 0.05
0.464TyrTrp: 0.464 ± 0.027
0.9TyrTyr: 0.9 ± 0.046
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 1828 proteins (685830 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski