Amino acid dipepetide frequency for SAR202 cluster bacterium AD-802-E10_MRT_200m

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.626AlaAla: 6.626 ± 0.263
1.005AlaCys: 1.005 ± 0.07
3.588AlaAsp: 3.588 ± 0.16
4.76AlaGlu: 4.76 ± 0.177
3.255AlaPhe: 3.255 ± 0.152
5.71AlaGly: 5.71 ± 0.198
1.633AlaHis: 1.633 ± 0.1
5.954AlaIle: 5.954 ± 0.201
3.494AlaLys: 3.494 ± 0.128
8.759AlaLeu: 8.759 ± 0.223
2.327AlaMet: 2.327 ± 0.115
2.705AlaAsn: 2.705 ± 0.116
2.777AlaPro: 2.777 ± 0.12
2.799AlaGln: 2.799 ± 0.118
4.243AlaArg: 4.243 ± 0.164
4.988AlaSer: 4.988 ± 0.163
4.466AlaThr: 4.466 ± 0.164
6.049AlaVal: 6.049 ± 0.216
0.833AlaTrp: 0.833 ± 0.072
2.122AlaTyr: 2.122 ± 0.112
0.0AlaXaa: 0.0 ± 0.0
Cys
0.744CysAla: 0.744 ± 0.078
0.122CysCys: 0.122 ± 0.026
0.533CysAsp: 0.533 ± 0.059
0.578CysGlu: 0.578 ± 0.058
0.383CysPhe: 0.383 ± 0.047
0.95CysGly: 0.95 ± 0.082
0.228CysHis: 0.228 ± 0.035
0.644CysIle: 0.644 ± 0.057
0.333CysLys: 0.333 ± 0.044
1.133CysLeu: 1.133 ± 0.082
0.244CysMet: 0.244 ± 0.047
0.339CysAsn: 0.339 ± 0.042
0.667CysPro: 0.667 ± 0.066
0.361CysGln: 0.361 ± 0.046
0.433CysArg: 0.433 ± 0.041
0.778CysSer: 0.778 ± 0.069
0.572CysThr: 0.572 ± 0.065
0.594CysVal: 0.594 ± 0.06
0.111CysTrp: 0.111 ± 0.027
0.322CysTyr: 0.322 ± 0.046
0.0CysXaa: 0.0 ± 0.0
Asp
3.477AspAla: 3.477 ± 0.157
0.494AspCys: 0.494 ± 0.059
2.022AspAsp: 2.022 ± 0.106
3.099AspGlu: 3.099 ± 0.159
2.088AspPhe: 2.088 ± 0.102
3.694AspGly: 3.694 ± 0.168
1.128AspHis: 1.128 ± 0.084
3.827AspIle: 3.827 ± 0.143
1.677AspLys: 1.677 ± 0.107
5.754AspLeu: 5.754 ± 0.184
1.039AspMet: 1.039 ± 0.071
1.672AspAsn: 1.672 ± 0.105
2.572AspPro: 2.572 ± 0.127
2.033AspGln: 2.033 ± 0.116
2.916AspArg: 2.916 ± 0.133
3.144AspSer: 3.144 ± 0.128
2.655AspThr: 2.655 ± 0.13
3.777AspVal: 3.777 ± 0.143
0.7AspTrp: 0.7 ± 0.062
1.738AspTyr: 1.738 ± 0.103
0.0AspXaa: 0.0 ± 0.0
Glu
5.182GluAla: 5.182 ± 0.187
0.628GluCys: 0.628 ± 0.058
2.899GluAsp: 2.899 ± 0.146
4.754GluGlu: 4.754 ± 0.188
2.749GluPhe: 2.749 ± 0.136
4.232GluGly: 4.232 ± 0.171
1.422GluHis: 1.422 ± 0.097
5.243GluIle: 5.243 ± 0.176
2.749GluLys: 2.749 ± 0.123
7.082GluLeu: 7.082 ± 0.219
1.561GluMet: 1.561 ± 0.104
2.705GluAsn: 2.705 ± 0.132
2.283GluPro: 2.283 ± 0.124
2.805GluGln: 2.805 ± 0.133
3.66GluArg: 3.66 ± 0.17
4.105GluSer: 4.105 ± 0.161
3.921GluThr: 3.921 ± 0.156
4.482GluVal: 4.482 ± 0.166
0.639GluTrp: 0.639 ± 0.067
1.677GluTyr: 1.677 ± 0.1
0.0GluXaa: 0.0 ± 0.0
Phe
2.933PheAla: 2.933 ± 0.15
0.444PheCys: 0.444 ± 0.048
2.116PheAsp: 2.116 ± 0.108
2.416PheGlu: 2.416 ± 0.118
1.322PhePhe: 1.322 ± 0.109
3.76PheGly: 3.76 ± 0.142
0.961PheHis: 0.961 ± 0.076
2.649PheIle: 2.649 ± 0.122
1.383PheLys: 1.383 ± 0.072
4.416PheLeu: 4.416 ± 0.171
0.705PheMet: 0.705 ± 0.062
1.583PheAsn: 1.583 ± 0.12
1.972PhePro: 1.972 ± 0.111
1.6PheGln: 1.6 ± 0.106
2.205PheArg: 2.205 ± 0.11
3.033PheSer: 3.033 ± 0.137
2.216PheThr: 2.216 ± 0.116
2.733PheVal: 2.733 ± 0.134
0.528PheTrp: 0.528 ± 0.07
1.355PheTyr: 1.355 ± 0.094
0.0PheXaa: 0.0 ± 0.0
Gly
5.876GlyAla: 5.876 ± 0.225
0.828GlyCys: 0.828 ± 0.07
3.588GlyAsp: 3.588 ± 0.115
4.405GlyGlu: 4.405 ± 0.168
3.61GlyPhe: 3.61 ± 0.148
5.732GlyGly: 5.732 ± 0.215
1.8GlyHis: 1.8 ± 0.095
6.521GlyIle: 6.521 ± 0.22
3.721GlyLys: 3.721 ± 0.14
8.387GlyLeu: 8.387 ± 0.26
2.116GlyMet: 2.116 ± 0.11
2.783GlyAsn: 2.783 ± 0.132
3.171GlyPro: 3.171 ± 0.14
2.838GlyGln: 2.838 ± 0.128
4.166GlyArg: 4.166 ± 0.157
5.21GlySer: 5.21 ± 0.178
4.455GlyThr: 4.455 ± 0.166
5.688GlyVal: 5.688 ± 0.215
1.25GlyTrp: 1.25 ± 0.093
2.611GlyTyr: 2.611 ± 0.121
0.0GlyXaa: 0.0 ± 0.0
His
1.655HisAla: 1.655 ± 0.105
0.311HisCys: 0.311 ± 0.034
0.889HisAsp: 0.889 ± 0.076
1.316HisGlu: 1.316 ± 0.092
0.811HisPhe: 0.811 ± 0.077
1.766HisGly: 1.766 ± 0.106
0.428HisHis: 0.428 ± 0.052
1.322HisIle: 1.322 ± 0.08
0.728HisLys: 0.728 ± 0.056
2.338HisLeu: 2.338 ± 0.115
0.483HisMet: 0.483 ± 0.053
0.75HisAsn: 0.75 ± 0.076
1.555HisPro: 1.555 ± 0.1
0.878HisGln: 0.878 ± 0.073
1.311HisArg: 1.311 ± 0.09
1.4HisSer: 1.4 ± 0.087
1.111HisThr: 1.111 ± 0.086
1.427HisVal: 1.427 ± 0.093
0.272HisTrp: 0.272 ± 0.039
0.672HisTyr: 0.672 ± 0.062
0.0HisXaa: 0.0 ± 0.0
Ile
6.243IleAla: 6.243 ± 0.214
0.744IleCys: 0.744 ± 0.063
3.949IleAsp: 3.949 ± 0.15
4.649IleGlu: 4.649 ± 0.202
2.772IlePhe: 2.772 ± 0.133
6.149IleGly: 6.149 ± 0.238
1.366IleHis: 1.366 ± 0.083
4.782IleIle: 4.782 ± 0.194
2.922IleLys: 2.922 ± 0.111
7.393IleLeu: 7.393 ± 0.253
1.622IleMet: 1.622 ± 0.093
2.833IleAsn: 2.833 ± 0.133
3.988IlePro: 3.988 ± 0.15
2.905IleGln: 2.905 ± 0.132
3.616IleArg: 3.616 ± 0.147
5.177IleSer: 5.177 ± 0.157
4.332IleThr: 4.332 ± 0.154
5.138IleVal: 5.138 ± 0.173
0.778IleTrp: 0.778 ± 0.071
1.689IleTyr: 1.689 ± 0.097
0.0IleXaa: 0.0 ± 0.0
Lys
3.016LysAla: 3.016 ± 0.121
0.317LysCys: 0.317 ± 0.043
2.372LysAsp: 2.372 ± 0.11
3.105LysGlu: 3.105 ± 0.146
1.472LysPhe: 1.472 ± 0.088
2.755LysGly: 2.755 ± 0.139
0.866LysHis: 0.866 ± 0.073
3.099LysIle: 3.099 ± 0.131
1.85LysLys: 1.85 ± 0.107
4.116LysLeu: 4.116 ± 0.142
0.822LysMet: 0.822 ± 0.063
1.722LysAsn: 1.722 ± 0.093
1.877LysPro: 1.877 ± 0.087
1.622LysGln: 1.622 ± 0.092
2.433LysArg: 2.433 ± 0.126
2.816LysSer: 2.816 ± 0.13
2.499LysThr: 2.499 ± 0.129
2.972LysVal: 2.972 ± 0.133
0.367LysTrp: 0.367 ± 0.044
1.061LysTyr: 1.061 ± 0.073
0.0LysXaa: 0.0 ± 0.0
Leu
9.365LeuAla: 9.365 ± 0.233
0.95LeuCys: 0.95 ± 0.074
5.671LeuAsp: 5.671 ± 0.178
7.409LeuGlu: 7.409 ± 0.226
3.894LeuPhe: 3.894 ± 0.175
9.237LeuGly: 9.237 ± 0.257
2.083LeuHis: 2.083 ± 0.109
7.354LeuIle: 7.354 ± 0.258
4.466LeuLys: 4.466 ± 0.171
11.109LeuLeu: 11.109 ± 0.315
2.366LeuMet: 2.366 ± 0.121
4.205LeuAsn: 4.205 ± 0.141
4.799LeuPro: 4.799 ± 0.151
3.949LeuGln: 3.949 ± 0.149
5.471LeuArg: 5.471 ± 0.202
7.293LeuSer: 7.293 ± 0.19
6.121LeuThr: 6.121 ± 0.183
7.221LeuVal: 7.221 ± 0.248
1.089LeuTrp: 1.089 ± 0.077
2.361LeuTyr: 2.361 ± 0.127
0.0LeuXaa: 0.0 ± 0.0
Met
2.394MetAla: 2.394 ± 0.121
0.161MetCys: 0.161 ± 0.027
1.289MetAsp: 1.289 ± 0.079
1.55MetGlu: 1.55 ± 0.102
0.766MetPhe: 0.766 ± 0.073
2.388MetGly: 2.388 ± 0.131
0.422MetHis: 0.422 ± 0.042
1.494MetIle: 1.494 ± 0.094
1.166MetLys: 1.166 ± 0.08
2.222MetLeu: 2.222 ± 0.092
0.7MetMet: 0.7 ± 0.062
1.0MetAsn: 1.0 ± 0.076
1.233MetPro: 1.233 ± 0.098
0.766MetGln: 0.766 ± 0.06
1.355MetArg: 1.355 ± 0.075
1.561MetSer: 1.561 ± 0.096
1.489MetThr: 1.489 ± 0.08
1.594MetVal: 1.594 ± 0.09
0.194MetTrp: 0.194 ± 0.029
0.6MetTyr: 0.6 ± 0.056
0.0MetXaa: 0.0 ± 0.0
Asn
2.866AsnAla: 2.866 ± 0.103
0.378AsnCys: 0.378 ± 0.041
1.744AsnAsp: 1.744 ± 0.099
2.194AsnGlu: 2.194 ± 0.103
1.527AsnPhe: 1.527 ± 0.098
2.527AsnGly: 2.527 ± 0.118
0.922AsnHis: 0.922 ± 0.067
2.522AsnIle: 2.522 ± 0.111
1.427AsnLys: 1.427 ± 0.078
4.593AsnLeu: 4.593 ± 0.157
0.85AsnMet: 0.85 ± 0.073
1.533AsnAsn: 1.533 ± 0.097
2.472AsnPro: 2.472 ± 0.108
1.5AsnGln: 1.5 ± 0.097
2.322AsnArg: 2.322 ± 0.116
2.516AsnSer: 2.516 ± 0.131
2.105AsnThr: 2.105 ± 0.113
2.822AsnVal: 2.822 ± 0.129
0.617AsnTrp: 0.617 ± 0.057
1.083AsnTyr: 1.083 ± 0.077
0.0AsnXaa: 0.0 ± 0.0
Pro
2.827ProAla: 2.827 ± 0.124
0.378ProCys: 0.378 ± 0.047
2.733ProAsp: 2.733 ± 0.124
3.677ProGlu: 3.677 ± 0.145
1.977ProPhe: 1.977 ± 0.128
3.555ProGly: 3.555 ± 0.149
1.0ProHis: 1.0 ± 0.066
3.682ProIle: 3.682 ± 0.159
1.933ProLys: 1.933 ± 0.103
4.227ProLeu: 4.227 ± 0.17
1.25ProMet: 1.25 ± 0.081
1.994ProAsn: 1.994 ± 0.104
1.972ProPro: 1.972 ± 0.123
1.633ProGln: 1.633 ± 0.098
2.027ProArg: 2.027 ± 0.101
3.16ProSer: 3.16 ± 0.122
2.611ProThr: 2.611 ± 0.135
3.41ProVal: 3.41 ± 0.141
0.766ProTrp: 0.766 ± 0.074
1.55ProTyr: 1.55 ± 0.098
0.0ProXaa: 0.0 ± 0.0
Gln
3.105GlnAla: 3.105 ± 0.14
0.389GlnCys: 0.389 ± 0.044
1.966GlnAsp: 1.966 ± 0.117
3.194GlnGlu: 3.194 ± 0.146
1.372GlnPhe: 1.372 ± 0.077
2.794GlnGly: 2.794 ± 0.122
0.822GlnHis: 0.822 ± 0.067
2.799GlnIle: 2.799 ± 0.132
1.522GlnLys: 1.522 ± 0.088
3.799GlnLeu: 3.799 ± 0.167
1.139GlnMet: 1.139 ± 0.075
1.622GlnAsn: 1.622 ± 0.099
1.383GlnPro: 1.383 ± 0.09
1.577GlnGln: 1.577 ± 0.095
2.249GlnArg: 2.249 ± 0.123
2.561GlnSer: 2.561 ± 0.117
1.988GlnThr: 1.988 ± 0.118
2.605GlnVal: 2.605 ± 0.13
0.444GlnTrp: 0.444 ± 0.052
0.95GlnTyr: 0.95 ± 0.077
0.0GlnXaa: 0.0 ± 0.0
Arg
3.577ArgAla: 3.577 ± 0.147
0.572ArgCys: 0.572 ± 0.052
2.655ArgAsp: 2.655 ± 0.142
3.777ArgGlu: 3.777 ± 0.167
2.588ArgPhe: 2.588 ± 0.135
3.766ArgGly: 3.766 ± 0.139
1.078ArgHis: 1.078 ± 0.084
4.127ArgIle: 4.127 ± 0.188
2.222ArgLys: 2.222 ± 0.115
5.732ArgLeu: 5.732 ± 0.196
1.539ArgMet: 1.539 ± 0.099
2.122ArgAsn: 2.122 ± 0.107
2.561ArgPro: 2.561 ± 0.117
2.266ArgGln: 2.266 ± 0.111
3.321ArgArg: 3.321 ± 0.149
3.36ArgSer: 3.36 ± 0.158
2.849ArgThr: 2.849 ± 0.127
3.894ArgVal: 3.894 ± 0.164
0.567ArgTrp: 0.567 ± 0.059
1.572ArgTyr: 1.572 ± 0.091
0.0ArgXaa: 0.0 ± 0.0
Ser
4.854SerAla: 4.854 ± 0.139
0.683SerCys: 0.683 ± 0.066
3.227SerAsp: 3.227 ± 0.131
4.227SerGlu: 4.227 ± 0.153
2.788SerPhe: 2.788 ± 0.13
5.799SerGly: 5.799 ± 0.176
1.416SerHis: 1.416 ± 0.082
4.727SerIle: 4.727 ± 0.151
2.799SerLys: 2.799 ± 0.109
7.298SerLeu: 7.298 ± 0.216
1.661SerMet: 1.661 ± 0.105
2.599SerAsn: 2.599 ± 0.131
3.06SerPro: 3.06 ± 0.132
2.544SerGln: 2.544 ± 0.119
3.521SerArg: 3.521 ± 0.137
4.854SerSer: 4.854 ± 0.201
3.666SerThr: 3.666 ± 0.14
4.677SerVal: 4.677 ± 0.158
0.805SerTrp: 0.805 ± 0.065
2.033SerTyr: 2.033 ± 0.104
0.0SerXaa: 0.0 ± 0.0
Thr
4.382ThrAla: 4.382 ± 0.151
0.55ThrCys: 0.55 ± 0.059
2.555ThrAsp: 2.555 ± 0.123
3.055ThrGlu: 3.055 ± 0.132
2.311ThrPhe: 2.311 ± 0.113
4.927ThrGly: 4.927 ± 0.18
1.344ThrHis: 1.344 ± 0.101
4.343ThrIle: 4.343 ± 0.142
2.244ThrLys: 2.244 ± 0.118
6.221ThrLeu: 6.221 ± 0.178
1.311ThrMet: 1.311 ± 0.089
2.072ThrAsn: 2.072 ± 0.122
2.983ThrPro: 2.983 ± 0.139
2.083ThrGln: 2.083 ± 0.106
2.899ThrArg: 2.899 ± 0.131
3.782ThrSer: 3.782 ± 0.149
3.127ThrThr: 3.127 ± 0.123
3.955ThrVal: 3.955 ± 0.163
0.672ThrTrp: 0.672 ± 0.063
1.727ThrTyr: 1.727 ± 0.087
0.0ThrXaa: 0.0 ± 0.0
Val
5.982ValAla: 5.982 ± 0.204
0.733ValCys: 0.733 ± 0.073
3.577ValAsp: 3.577 ± 0.138
4.349ValGlu: 4.349 ± 0.161
2.905ValPhe: 2.905 ± 0.148
5.699ValGly: 5.699 ± 0.206
1.489ValHis: 1.489 ± 0.096
5.388ValIle: 5.388 ± 0.19
2.822ValLys: 2.822 ± 0.123
7.504ValLeu: 7.504 ± 0.219
1.716ValMet: 1.716 ± 0.099
2.749ValAsn: 2.749 ± 0.139
3.194ValPro: 3.194 ± 0.162
2.472ValGln: 2.472 ± 0.12
3.588ValArg: 3.588 ± 0.187
4.816ValSer: 4.816 ± 0.177
4.421ValThr: 4.421 ± 0.147
5.315ValVal: 5.315 ± 0.218
0.766ValTrp: 0.766 ± 0.071
1.555ValTyr: 1.555 ± 0.1
0.0ValXaa: 0.0 ± 0.0
Trp
0.855TrpAla: 0.855 ± 0.08
0.072TrpCys: 0.072 ± 0.02
0.589TrpAsp: 0.589 ± 0.061
0.766TrpGlu: 0.766 ± 0.065
0.533TrpPhe: 0.533 ± 0.055
1.061TrpGly: 1.061 ± 0.086
0.255TrpHis: 0.255 ± 0.033
0.855TrpIle: 0.855 ± 0.082
0.578TrpLys: 0.578 ± 0.055
1.194TrpLeu: 1.194 ± 0.084
0.283TrpMet: 0.283 ± 0.038
0.517TrpAsn: 0.517 ± 0.05
0.428TrpPro: 0.428 ± 0.038
0.522TrpGln: 0.522 ± 0.059
0.644TrpArg: 0.644 ± 0.065
0.722TrpSer: 0.722 ± 0.074
0.55TrpThr: 0.55 ± 0.06
1.05TrpVal: 1.05 ± 0.084
0.255TrpTrp: 0.255 ± 0.045
0.35TrpTyr: 0.35 ± 0.045
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.138TyrAla: 2.138 ± 0.102
0.311TyrCys: 0.311 ± 0.046
1.544TyrAsp: 1.544 ± 0.079
1.5TyrGlu: 1.5 ± 0.077
1.205TyrPhe: 1.205 ± 0.078
2.255TyrGly: 2.255 ± 0.112
0.761TyrHis: 0.761 ± 0.069
1.711TyrIle: 1.711 ± 0.099
1.122TyrLys: 1.122 ± 0.082
3.133TyrLeu: 3.133 ± 0.129
0.605TyrMet: 0.605 ± 0.058
1.016TyrAsn: 1.016 ± 0.074
1.416TyrPro: 1.416 ± 0.097
1.128TyrGln: 1.128 ± 0.079
1.761TyrArg: 1.761 ± 0.105
1.966TyrSer: 1.966 ± 0.106
1.389TyrThr: 1.389 ± 0.105
1.639TyrVal: 1.639 ± 0.109
0.428TyrTrp: 0.428 ± 0.048
0.855TyrTyr: 0.855 ± 0.074
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 589 proteins (180042 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski