Amino acid dipepetide frequency for Sulfolobus turreted icosahedral virus 2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.006AlaAla: 5.006 ± 1.992
0.185AlaCys: 0.185 ± 0.198
3.152AlaAsp: 3.152 ± 1.067
4.079AlaGlu: 4.079 ± 0.977
1.483AlaPhe: 1.483 ± 0.608
5.191AlaGly: 5.191 ± 1.394
0.927AlaHis: 0.927 ± 0.362
5.933AlaIle: 5.933 ± 1.055
4.079AlaLys: 4.079 ± 0.729
8.157AlaLeu: 8.157 ± 1.32
0.927AlaMet: 0.927 ± 0.376
2.41AlaAsn: 2.41 ± 0.817
3.152AlaPro: 3.152 ± 0.819
2.225AlaGln: 2.225 ± 0.778
2.039AlaArg: 2.039 ± 0.739
4.449AlaSer: 4.449 ± 1.433
3.522AlaThr: 3.522 ± 0.664
2.41AlaVal: 2.41 ± 0.596
0.371AlaTrp: 0.371 ± 0.208
2.595AlaTyr: 2.595 ± 0.485
0.0AlaXaa: 0.0 ± 0.0
Cys
0.556CysAla: 0.556 ± 0.35
0.185CysCys: 0.185 ± 0.192
0.0CysAsp: 0.0 ± 0.0
0.185CysGlu: 0.185 ± 0.198
0.185CysPhe: 0.185 ± 0.211
0.556CysGly: 0.556 ± 0.353
0.185CysHis: 0.185 ± 0.173
0.742CysIle: 0.742 ± 0.368
0.556CysLys: 0.556 ± 0.434
0.556CysLeu: 0.556 ± 0.321
0.185CysMet: 0.185 ± 0.178
0.185CysAsn: 0.185 ± 0.187
0.371CysPro: 0.371 ± 0.251
0.371CysGln: 0.371 ± 0.309
0.0CysArg: 0.0 ± 0.0
0.742CysSer: 0.742 ± 0.339
0.556CysThr: 0.556 ± 0.364
0.185CysVal: 0.185 ± 0.173
0.0CysTrp: 0.0 ± 0.0
0.556CysTyr: 0.556 ± 0.298
0.0CysXaa: 0.0 ± 0.0
Asp
1.298AspAla: 1.298 ± 0.452
0.0AspCys: 0.0 ± 0.0
1.298AspAsp: 1.298 ± 0.634
5.747AspGlu: 5.747 ± 1.009
2.41AspPhe: 2.41 ± 0.645
1.298AspGly: 1.298 ± 0.444
0.371AspHis: 0.371 ± 0.221
4.82AspIle: 4.82 ± 0.749
2.781AspLys: 2.781 ± 0.931
7.601AspLeu: 7.601 ± 1.91
0.556AspMet: 0.556 ± 0.431
2.039AspAsn: 2.039 ± 0.595
1.298AspPro: 1.298 ± 0.517
0.185AspGln: 0.185 ± 0.182
0.742AspArg: 0.742 ± 0.341
2.41AspSer: 2.41 ± 0.486
2.039AspThr: 2.039 ± 0.569
3.152AspVal: 3.152 ± 0.681
0.185AspTrp: 0.185 ± 0.165
1.112AspTyr: 1.112 ± 0.53
0.0AspXaa: 0.0 ± 0.0
Glu
3.893GluAla: 3.893 ± 0.818
0.371GluCys: 0.371 ± 0.282
3.708GluAsp: 3.708 ± 1.037
9.64GluGlu: 9.64 ± 2.44
3.337GluPhe: 3.337 ± 0.771
5.191GluGly: 5.191 ± 1.207
0.556GluHis: 0.556 ± 0.374
7.972GluIle: 7.972 ± 1.901
9.826GluLys: 9.826 ± 2.665
7.045GluLeu: 7.045 ± 1.334
1.483GluMet: 1.483 ± 0.542
2.039GluAsn: 2.039 ± 0.57
1.298GluPro: 1.298 ± 0.482
2.039GluGln: 2.039 ± 0.807
4.635GluArg: 4.635 ± 0.643
3.152GluSer: 3.152 ± 1.11
4.079GluThr: 4.079 ± 0.815
4.079GluVal: 4.079 ± 1.011
0.185GluTrp: 0.185 ± 0.204
3.522GluTyr: 3.522 ± 0.801
0.0GluXaa: 0.0 ± 0.0
Phe
2.966PheAla: 2.966 ± 0.69
0.742PheCys: 0.742 ± 0.361
1.483PheAsp: 1.483 ± 0.548
2.781PheGlu: 2.781 ± 0.751
3.152PhePhe: 3.152 ± 0.774
3.708PheGly: 3.708 ± 0.983
0.185PheHis: 0.185 ± 0.177
2.781PheIle: 2.781 ± 0.796
2.595PheLys: 2.595 ± 0.602
4.635PheLeu: 4.635 ± 1.388
1.298PheMet: 1.298 ± 0.513
2.039PheAsn: 2.039 ± 0.616
1.483PhePro: 1.483 ± 0.424
0.742PheGln: 0.742 ± 0.414
1.854PheArg: 1.854 ± 0.581
2.781PheSer: 2.781 ± 1.042
2.41PheThr: 2.41 ± 0.742
1.483PheVal: 1.483 ± 0.423
0.371PheTrp: 0.371 ± 0.297
1.854PheTyr: 1.854 ± 0.561
0.0PheXaa: 0.0 ± 0.0
Gly
4.635GlyAla: 4.635 ± 1.062
0.185GlyCys: 0.185 ± 0.165
2.039GlyAsp: 2.039 ± 0.655
4.635GlyGlu: 4.635 ± 0.856
3.522GlyPhe: 3.522 ± 1.015
4.264GlyGly: 4.264 ± 1.038
0.556GlyHis: 0.556 ± 0.405
4.82GlyIle: 4.82 ± 0.968
3.522GlyLys: 3.522 ± 1.194
8.343GlyLeu: 8.343 ± 1.679
1.112GlyMet: 1.112 ± 0.463
2.41GlyAsn: 2.41 ± 1.27
0.0GlyPro: 0.0 ± 0.0
1.854GlyGln: 1.854 ± 0.62
2.41GlyArg: 2.41 ± 0.592
4.264GlySer: 4.264 ± 0.968
4.82GlyThr: 4.82 ± 1.137
3.708GlyVal: 3.708 ± 1.096
0.0GlyTrp: 0.0 ± 0.0
1.669GlyTyr: 1.669 ± 0.595
0.0GlyXaa: 0.0 ± 0.0
His
1.483HisAla: 1.483 ± 0.494
0.185HisCys: 0.185 ± 0.173
0.742HisAsp: 0.742 ± 0.4
1.112HisGlu: 1.112 ± 0.63
1.112HisPhe: 1.112 ± 0.424
0.927HisGly: 0.927 ± 0.386
0.0HisHis: 0.0 ± 0.0
0.927HisIle: 0.927 ± 0.406
2.225HisLys: 2.225 ± 0.671
0.927HisLeu: 0.927 ± 0.336
0.185HisMet: 0.185 ± 0.173
0.556HisAsn: 0.556 ± 0.406
1.298HisPro: 1.298 ± 0.545
0.185HisGln: 0.185 ± 0.177
0.371HisArg: 0.371 ± 0.274
0.927HisSer: 0.927 ± 0.352
0.371HisThr: 0.371 ± 0.243
0.742HisVal: 0.742 ± 0.417
0.185HisTrp: 0.185 ± 0.165
0.927HisTyr: 0.927 ± 0.33
0.0HisXaa: 0.0 ± 0.0
Ile
6.489IleAla: 6.489 ± 0.955
0.742IleCys: 0.742 ± 0.379
4.079IleAsp: 4.079 ± 0.848
7.601IleGlu: 7.601 ± 1.227
3.152IlePhe: 3.152 ± 0.928
3.337IleGly: 3.337 ± 0.689
2.41IleHis: 2.41 ± 0.587
8.899IleIle: 8.899 ± 1.918
8.528IleLys: 8.528 ± 1.355
6.859IleLeu: 6.859 ± 1.138
2.039IleMet: 2.039 ± 0.576
4.264IleAsn: 4.264 ± 0.791
3.522IlePro: 3.522 ± 0.913
2.595IleGln: 2.595 ± 0.77
3.522IleArg: 3.522 ± 0.984
7.416IleSer: 7.416 ± 1.172
5.006IleThr: 5.006 ± 0.872
5.562IleVal: 5.562 ± 1.165
0.556IleTrp: 0.556 ± 0.38
3.708IleTyr: 3.708 ± 0.719
0.0IleXaa: 0.0 ± 0.0
Lys
3.522LysAla: 3.522 ± 0.889
0.556LysCys: 0.556 ± 0.295
5.006LysAsp: 5.006 ± 1.273
9.455LysGlu: 9.455 ± 2.714
3.337LysPhe: 3.337 ± 0.789
3.337LysGly: 3.337 ± 0.649
1.854LysHis: 1.854 ± 0.642
8.157LysIle: 8.157 ± 1.261
11.494LysLys: 11.494 ± 3.14
6.489LysLeu: 6.489 ± 1.462
2.039LysMet: 2.039 ± 0.704
3.337LysAsn: 3.337 ± 0.935
2.966LysPro: 2.966 ± 0.875
3.152LysGln: 3.152 ± 0.708
3.152LysArg: 3.152 ± 0.955
2.781LysSer: 2.781 ± 0.814
2.966LysThr: 2.966 ± 0.688
5.376LysVal: 5.376 ± 1.085
0.742LysTrp: 0.742 ± 0.555
4.079LysTyr: 4.079 ± 0.752
0.0LysXaa: 0.0 ± 0.0
Leu
8.343LeuAla: 8.343 ± 1.337
0.742LeuCys: 0.742 ± 0.393
4.82LeuAsp: 4.82 ± 0.917
5.191LeuGlu: 5.191 ± 0.989
3.708LeuPhe: 3.708 ± 0.781
8.157LeuGly: 8.157 ± 1.521
1.669LeuHis: 1.669 ± 0.689
8.713LeuIle: 8.713 ± 1.325
8.343LeuLys: 8.343 ± 1.859
9.084LeuLeu: 9.084 ± 1.438
1.854LeuMet: 1.854 ± 0.644
5.933LeuAsn: 5.933 ± 1.072
4.264LeuPro: 4.264 ± 0.963
3.893LeuGln: 3.893 ± 0.78
5.191LeuArg: 5.191 ± 1.197
8.157LeuSer: 8.157 ± 1.459
4.264LeuThr: 4.264 ± 0.9
6.118LeuVal: 6.118 ± 1.218
0.371LeuTrp: 0.371 ± 0.228
4.635LeuTyr: 4.635 ± 0.669
0.185LeuXaa: 0.185 ± 0.162
Met
0.927MetAla: 0.927 ± 0.332
0.0MetCys: 0.0 ± 0.0
0.927MetAsp: 0.927 ± 0.346
0.742MetGlu: 0.742 ± 0.399
0.742MetPhe: 0.742 ± 0.34
1.669MetGly: 1.669 ± 0.642
0.185MetHis: 0.185 ± 0.199
1.669MetIle: 1.669 ± 0.624
2.595MetLys: 2.595 ± 0.939
1.669MetLeu: 1.669 ± 0.767
0.185MetMet: 0.185 ± 0.176
1.112MetAsn: 1.112 ± 0.432
0.556MetPro: 0.556 ± 0.247
0.556MetGln: 0.556 ± 0.32
1.483MetArg: 1.483 ± 0.433
1.483MetSer: 1.483 ± 0.417
0.742MetThr: 0.742 ± 0.373
0.742MetVal: 0.742 ± 0.377
0.185MetTrp: 0.185 ± 0.167
0.927MetTyr: 0.927 ± 0.526
0.0MetXaa: 0.0 ± 0.0
Asn
3.152AsnAla: 3.152 ± 0.672
0.371AsnCys: 0.371 ± 0.299
2.039AsnAsp: 2.039 ± 0.541
5.006AsnGlu: 5.006 ± 0.962
2.41AsnPhe: 2.41 ± 0.674
3.152AsnGly: 3.152 ± 1.343
0.556AsnHis: 0.556 ± 0.32
3.152AsnIle: 3.152 ± 0.637
2.41AsnLys: 2.41 ± 0.734
4.82AsnLeu: 4.82 ± 1.057
0.556AsnMet: 0.556 ± 0.284
3.337AsnAsn: 3.337 ± 0.936
2.781AsnPro: 2.781 ± 0.801
2.225AsnGln: 2.225 ± 0.622
1.669AsnArg: 1.669 ± 0.496
4.264AsnSer: 4.264 ± 1.296
3.522AsnThr: 3.522 ± 1.033
2.966AsnVal: 2.966 ± 0.735
0.185AsnTrp: 0.185 ± 0.177
1.854AsnTyr: 1.854 ± 0.689
0.0AsnXaa: 0.0 ± 0.0
Pro
3.152ProAla: 3.152 ± 1.186
0.0ProCys: 0.0 ± 0.0
0.927ProAsp: 0.927 ± 0.346
2.966ProGlu: 2.966 ± 0.975
1.298ProPhe: 1.298 ± 0.394
2.225ProGly: 2.225 ± 0.515
0.742ProHis: 0.742 ± 0.374
2.966ProIle: 2.966 ± 0.513
2.41ProLys: 2.41 ± 0.747
4.264ProLeu: 4.264 ± 0.62
0.0ProMet: 0.0 ± 0.0
2.595ProAsn: 2.595 ± 0.57
2.039ProPro: 2.039 ± 1.186
0.742ProGln: 0.742 ± 0.36
0.742ProArg: 0.742 ± 0.353
6.303ProSer: 6.303 ± 2.622
1.669ProThr: 1.669 ± 0.732
1.669ProVal: 1.669 ± 0.807
0.0ProTrp: 0.0 ± 0.0
2.41ProTyr: 2.41 ± 1.015
0.0ProXaa: 0.0 ± 0.0
Gln
2.039GlnAla: 2.039 ± 0.84
0.742GlnCys: 0.742 ± 0.458
1.112GlnAsp: 1.112 ± 0.403
1.669GlnGlu: 1.669 ± 0.583
1.112GlnPhe: 1.112 ± 0.458
1.112GlnGly: 1.112 ± 0.659
0.556GlnHis: 0.556 ± 0.272
2.595GlnIle: 2.595 ± 0.725
3.522GlnLys: 3.522 ± 0.982
3.893GlnLeu: 3.893 ± 0.757
0.742GlnMet: 0.742 ± 0.288
2.781GlnAsn: 2.781 ± 0.782
1.112GlnPro: 1.112 ± 0.44
1.112GlnGln: 1.112 ± 0.429
1.669GlnArg: 1.669 ± 0.441
1.669GlnSer: 1.669 ± 0.692
1.854GlnThr: 1.854 ± 0.392
1.669GlnVal: 1.669 ± 0.557
0.185GlnTrp: 0.185 ± 0.153
0.927GlnTyr: 0.927 ± 0.383
0.0GlnXaa: 0.0 ± 0.0
Arg
1.854ArgAla: 1.854 ± 0.657
0.556ArgCys: 0.556 ± 0.461
1.483ArgAsp: 1.483 ± 0.561
3.708ArgGlu: 3.708 ± 0.667
1.298ArgPhe: 1.298 ± 0.468
1.854ArgGly: 1.854 ± 0.52
0.742ArgHis: 0.742 ± 0.311
2.41ArgIle: 2.41 ± 0.746
4.449ArgLys: 4.449 ± 1.075
4.635ArgLeu: 4.635 ± 1.163
1.483ArgMet: 1.483 ± 0.481
2.039ArgAsn: 2.039 ± 0.529
0.556ArgPro: 0.556 ± 0.26
1.669ArgGln: 1.669 ± 0.513
3.152ArgArg: 3.152 ± 0.805
1.669ArgSer: 1.669 ± 0.549
1.854ArgThr: 1.854 ± 0.454
2.781ArgVal: 2.781 ± 0.756
0.742ArgTrp: 0.742 ± 0.367
1.483ArgTyr: 1.483 ± 0.446
0.0ArgXaa: 0.0 ± 0.0
Ser
3.522SerAla: 3.522 ± 1.123
0.371SerCys: 0.371 ± 0.27
3.337SerAsp: 3.337 ± 0.834
2.41SerGlu: 2.41 ± 0.668
3.337SerPhe: 3.337 ± 0.999
4.449SerGly: 4.449 ± 1.139
0.742SerHis: 0.742 ± 0.385
6.859SerIle: 6.859 ± 1.251
3.522SerLys: 3.522 ± 0.935
7.601SerLeu: 7.601 ± 1.41
1.483SerMet: 1.483 ± 0.622
3.893SerAsn: 3.893 ± 0.972
6.674SerPro: 6.674 ± 2.533
2.595SerGln: 2.595 ± 0.586
1.483SerArg: 1.483 ± 0.474
11.123SerSer: 11.123 ± 2.884
4.449SerThr: 4.449 ± 1.318
3.337SerVal: 3.337 ± 0.947
0.556SerTrp: 0.556 ± 0.26
2.781SerTyr: 2.781 ± 0.64
0.0SerXaa: 0.0 ± 0.0
Thr
3.522ThrAla: 3.522 ± 1.039
0.0ThrCys: 0.0 ± 0.0
1.298ThrAsp: 1.298 ± 0.445
3.337ThrGlu: 3.337 ± 0.764
2.039ThrPhe: 2.039 ± 0.69
2.966ThrGly: 2.966 ± 0.877
1.298ThrHis: 1.298 ± 0.447
5.376ThrIle: 5.376 ± 1.242
3.708ThrLys: 3.708 ± 0.936
5.376ThrLeu: 5.376 ± 0.938
1.112ThrMet: 1.112 ± 0.35
2.225ThrAsn: 2.225 ± 0.758
2.225ThrPro: 2.225 ± 0.413
2.225ThrGln: 2.225 ± 0.563
1.854ThrArg: 1.854 ± 0.514
4.079ThrSer: 4.079 ± 1.545
3.708ThrThr: 3.708 ± 1.228
3.893ThrVal: 3.893 ± 1.019
0.185ThrTrp: 0.185 ± 0.186
2.966ThrTyr: 2.966 ± 0.656
0.0ThrXaa: 0.0 ± 0.0
Val
3.708ValAla: 3.708 ± 0.699
0.371ValCys: 0.371 ± 0.261
1.669ValAsp: 1.669 ± 0.798
3.708ValGlu: 3.708 ± 0.721
1.298ValPhe: 1.298 ± 0.381
2.595ValGly: 2.595 ± 0.751
0.742ValHis: 0.742 ± 0.424
5.562ValIle: 5.562 ± 0.999
4.635ValLys: 4.635 ± 1.267
6.118ValLeu: 6.118 ± 1.201
0.742ValMet: 0.742 ± 0.316
3.893ValAsn: 3.893 ± 1.593
2.225ValPro: 2.225 ± 0.776
2.41ValGln: 2.41 ± 0.674
2.781ValArg: 2.781 ± 0.698
3.337ValSer: 3.337 ± 0.696
3.708ValThr: 3.708 ± 1.1
5.006ValVal: 5.006 ± 1.105
1.298ValTrp: 1.298 ± 0.748
2.41ValTyr: 2.41 ± 0.668
0.0ValXaa: 0.0 ± 0.0
Trp
0.185TrpAla: 0.185 ± 0.167
0.0TrpCys: 0.0 ± 0.0
0.0TrpAsp: 0.0 ± 0.0
0.742TrpGlu: 0.742 ± 0.512
0.185TrpPhe: 0.185 ± 0.208
0.556TrpGly: 0.556 ± 0.305
0.0TrpHis: 0.0 ± 0.0
1.669TrpIle: 1.669 ± 0.707
0.556TrpLys: 0.556 ± 0.411
0.556TrpLeu: 0.556 ± 0.295
0.0TrpMet: 0.0 ± 0.0
0.371TrpAsn: 0.371 ± 0.271
0.0TrpPro: 0.0 ± 0.0
0.556TrpGln: 0.556 ± 0.369
0.371TrpArg: 0.371 ± 0.223
0.185TrpSer: 0.185 ± 0.167
0.185TrpThr: 0.185 ± 0.177
0.371TrpVal: 0.371 ± 0.242
0.185TrpTrp: 0.185 ± 0.153
0.371TrpTyr: 0.371 ± 0.223
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.039TyrAla: 2.039 ± 0.565
0.556TyrCys: 0.556 ± 0.344
2.225TyrAsp: 2.225 ± 0.577
3.337TyrGlu: 3.337 ± 0.972
2.225TyrPhe: 2.225 ± 0.579
2.225TyrGly: 2.225 ± 0.606
1.112TyrHis: 1.112 ± 0.473
4.264TyrIle: 4.264 ± 0.911
2.039TyrLys: 2.039 ± 0.517
5.006TyrLeu: 5.006 ± 0.724
0.927TyrMet: 0.927 ± 0.419
2.966TyrAsn: 2.966 ± 0.793
1.298TyrPro: 1.298 ± 0.547
0.742TyrGln: 0.742 ± 0.371
1.483TyrArg: 1.483 ± 0.541
3.337TyrSer: 3.337 ± 0.931
1.669TyrThr: 1.669 ± 0.567
2.966TyrVal: 2.966 ± 0.757
0.556TyrTrp: 0.556 ± 0.347
2.781TyrTyr: 2.781 ± 0.629
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.185XaaTyr: 0.185 ± 0.162
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 34 proteins (5395 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski