Amino acid dipepetide frequency for Listeria phage LP-039

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
0.767AlaAla: 0.767 ± 0.334
0.358AlaCys: 0.358 ± 0.088
3.297AlaAsp: 3.297 ± 0.296
4.421AlaGlu: 4.421 ± 0.374
2.096AlaPhe: 2.096 ± 0.214
3.936AlaGly: 3.936 ± 0.519
0.997AlaHis: 0.997 ± 0.132
4.268AlaIle: 4.268 ± 0.312
4.626AlaLys: 4.626 ± 0.319
5.546AlaLeu: 5.546 ± 0.418
1.457AlaMet: 1.457 ± 0.274
3.527AlaAsn: 3.527 ± 0.346
1.815AlaPro: 1.815 ± 0.33
2.121AlaGln: 2.121 ± 0.27
2.658AlaArg: 2.658 ± 0.27
4.626AlaSer: 4.626 ± 0.387
3.833AlaThr: 3.833 ± 0.315
4.038AlaVal: 4.038 ± 0.32
0.332AlaTrp: 0.332 ± 0.094
2.76AlaTyr: 2.76 ± 0.271
0.0AlaXaa: 0.0 ± 0.0
Cys
0.204CysAla: 0.204 ± 0.067
0.128CysCys: 0.128 ± 0.059
0.307CysAsp: 0.307 ± 0.103
0.383CysGlu: 0.383 ± 0.085
0.281CysPhe: 0.281 ± 0.076
0.486CysGly: 0.486 ± 0.113
0.179CysHis: 0.179 ± 0.067
0.383CysIle: 0.383 ± 0.096
0.613CysLys: 0.613 ± 0.119
0.46CysLeu: 0.46 ± 0.088
0.077CysMet: 0.077 ± 0.046
0.434CysAsn: 0.434 ± 0.112
0.358CysPro: 0.358 ± 0.087
0.281CysGln: 0.281 ± 0.09
0.256CysArg: 0.256 ± 0.08
0.511CysSer: 0.511 ± 0.136
0.23CysThr: 0.23 ± 0.075
0.434CysVal: 0.434 ± 0.098
0.026CysTrp: 0.026 ± 0.025
0.511CysTyr: 0.511 ± 0.141
0.0CysXaa: 0.0 ± 0.0
Asp
2.275AspAla: 2.275 ± 0.242
0.511AspCys: 0.511 ± 0.129
2.735AspAsp: 2.735 ± 0.273
3.987AspGlu: 3.987 ± 0.346
2.837AspPhe: 2.837 ± 0.283
3.271AspGly: 3.271 ± 0.301
0.434AspHis: 0.434 ± 0.119
4.447AspIle: 4.447 ± 0.334
5.929AspLys: 5.929 ± 0.396
5.648AspLeu: 5.648 ± 0.363
1.585AspMet: 1.585 ± 0.228
4.319AspAsn: 4.319 ± 0.321
1.533AspPro: 1.533 ± 0.183
1.431AspGln: 1.431 ± 0.239
2.709AspArg: 2.709 ± 0.265
4.166AspSer: 4.166 ± 0.29
3.552AspThr: 3.552 ± 0.263
3.731AspVal: 3.731 ± 0.366
0.716AspTrp: 0.716 ± 0.125
3.68AspTyr: 3.68 ± 0.349
0.0AspXaa: 0.0 ± 0.0
Glu
5.648GluAla: 5.648 ± 0.381
0.537GluCys: 0.537 ± 0.136
5.188GluAsp: 5.188 ± 0.429
8.996GluGlu: 8.996 ± 0.863
2.965GluPhe: 2.965 ± 0.281
4.242GluGly: 4.242 ± 0.366
1.048GluHis: 1.048 ± 0.209
4.498GluIle: 4.498 ± 0.381
7.897GluLys: 7.897 ± 0.603
7.641GluLeu: 7.641 ± 0.454
1.866GluMet: 1.866 ± 0.195
4.268GluAsn: 4.268 ± 0.295
1.661GluPro: 1.661 ± 0.238
3.041GluGln: 3.041 ± 0.287
3.552GluArg: 3.552 ± 0.265
4.702GluSer: 4.702 ± 0.326
4.14GluThr: 4.14 ± 0.314
6.134GluVal: 6.134 ± 0.489
0.716GluTrp: 0.716 ± 0.141
3.067GluTyr: 3.067 ± 0.316
0.0GluXaa: 0.0 ± 0.0
Phe
1.789PheAla: 1.789 ± 0.188
0.281PheCys: 0.281 ± 0.09
2.172PheAsp: 2.172 ± 0.248
2.479PheGlu: 2.479 ± 0.253
1.738PhePhe: 1.738 ± 0.181
2.249PheGly: 2.249 ± 0.268
0.613PheHis: 0.613 ± 0.111
2.888PheIle: 2.888 ± 0.309
2.658PheLys: 2.658 ± 0.215
3.885PheLeu: 3.885 ± 0.343
1.073PheMet: 1.073 ± 0.167
2.198PheAsn: 2.198 ± 0.299
1.022PhePro: 1.022 ± 0.171
1.124PheGln: 1.124 ± 0.159
1.252PheArg: 1.252 ± 0.144
3.22PheSer: 3.22 ± 0.325
2.53PheThr: 2.53 ± 0.252
3.297PheVal: 3.297 ± 0.325
0.23PheTrp: 0.23 ± 0.074
2.275PheTyr: 2.275 ± 0.239
0.0PheXaa: 0.0 ± 0.0
Gly
3.782GlyAla: 3.782 ± 0.706
0.486GlyCys: 0.486 ± 0.123
3.706GlyAsp: 3.706 ± 0.384
3.936GlyGlu: 3.936 ± 0.331
2.045GlyPhe: 2.045 ± 0.216
4.83GlyGly: 4.83 ± 0.802
0.894GlyHis: 0.894 ± 0.161
4.345GlyIle: 4.345 ± 0.3
5.29GlyLys: 5.29 ± 0.463
4.063GlyLeu: 4.063 ± 0.357
1.763GlyMet: 1.763 ± 0.243
3.859GlyAsn: 3.859 ± 0.317
0.026GlyPro: 0.026 ± 0.027
1.508GlyGln: 1.508 ± 0.207
2.249GlyArg: 2.249 ± 0.216
4.268GlySer: 4.268 ± 0.472
3.936GlyThr: 3.936 ± 0.385
4.575GlyVal: 4.575 ± 0.386
0.613GlyTrp: 0.613 ± 0.12
2.786GlyTyr: 2.786 ± 0.241
0.0GlyXaa: 0.0 ± 0.0
His
0.767HisAla: 0.767 ± 0.14
0.179HisCys: 0.179 ± 0.062
0.894HisAsp: 0.894 ± 0.2
0.869HisGlu: 0.869 ± 0.131
0.537HisPhe: 0.537 ± 0.125
0.741HisGly: 0.741 ± 0.134
0.281HisHis: 0.281 ± 0.1
1.227HisIle: 1.227 ± 0.256
1.278HisLys: 1.278 ± 0.21
1.406HisLeu: 1.406 ± 0.189
0.256HisMet: 0.256 ± 0.079
0.741HisAsn: 0.741 ± 0.129
0.434HisPro: 0.434 ± 0.109
0.383HisGln: 0.383 ± 0.083
0.588HisArg: 0.588 ± 0.127
0.997HisSer: 0.997 ± 0.173
0.997HisThr: 0.997 ± 0.171
1.15HisVal: 1.15 ± 0.242
0.307HisTrp: 0.307 ± 0.122
0.843HisTyr: 0.843 ± 0.153
0.0HisXaa: 0.0 ± 0.0
Ile
4.421IleAla: 4.421 ± 0.383
0.383IleCys: 0.383 ± 0.095
4.115IleAsp: 4.115 ± 0.295
5.725IleGlu: 5.725 ± 0.437
1.738IlePhe: 1.738 ± 0.229
3.961IleGly: 3.961 ± 0.347
1.176IleHis: 1.176 ± 0.184
4.958IleIle: 4.958 ± 0.39
5.367IleLys: 5.367 ± 0.364
5.086IleLeu: 5.086 ± 0.4
1.917IleMet: 1.917 ± 0.213
3.399IleAsn: 3.399 ± 0.333
2.428IlePro: 2.428 ± 0.253
2.249IleGln: 2.249 ± 0.219
2.99IleArg: 2.99 ± 0.237
4.575IleSer: 4.575 ± 0.358
4.038IleThr: 4.038 ± 0.342
4.677IleVal: 4.677 ± 0.367
0.511IleTrp: 0.511 ± 0.119
2.377IleTyr: 2.377 ± 0.23
0.0IleXaa: 0.0 ± 0.0
Lys
4.984LysAla: 4.984 ± 0.395
0.332LysCys: 0.332 ± 0.128
5.597LysAsp: 5.597 ± 0.41
9.456LysGlu: 9.456 ± 0.526
3.067LysPhe: 3.067 ± 0.243
5.137LysGly: 5.137 ± 0.408
1.354LysHis: 1.354 ± 0.2
5.035LysIle: 5.035 ± 0.431
8.715LysLys: 8.715 ± 0.561
6.747LysLeu: 6.747 ± 0.487
1.968LysMet: 1.968 ± 0.204
5.035LysAsn: 5.035 ± 0.349
2.786LysPro: 2.786 ± 0.285
3.271LysGln: 3.271 ± 0.296
3.22LysArg: 3.22 ± 0.286
4.779LysSer: 4.779 ± 0.37
4.702LysThr: 4.702 ± 0.359
6.21LysVal: 6.21 ± 0.468
0.869LysTrp: 0.869 ± 0.144
3.45LysTyr: 3.45 ± 0.271
0.0LysXaa: 0.0 ± 0.0
Leu
6.415LeuAla: 6.415 ± 0.361
0.69LeuCys: 0.69 ± 0.132
5.929LeuAsp: 5.929 ± 0.316
7.232LeuGlu: 7.232 ± 0.467
3.297LeuPhe: 3.297 ± 0.373
5.392LeuGly: 5.392 ± 0.387
0.92LeuHis: 0.92 ± 0.164
4.319LeuIle: 4.319 ± 0.317
6.415LeuLys: 6.415 ± 0.393
6.67LeuLeu: 6.67 ± 0.444
1.942LeuMet: 1.942 ± 0.216
4.779LeuAsn: 4.779 ± 0.349
3.246LeuPro: 3.246 ± 0.371
2.913LeuGln: 2.913 ± 0.299
3.757LeuArg: 3.757 ± 0.363
5.418LeuSer: 5.418 ± 0.365
5.111LeuThr: 5.111 ± 0.386
6.082LeuVal: 6.082 ± 0.421
0.818LeuTrp: 0.818 ± 0.123
3.271LeuTyr: 3.271 ± 0.271
0.0LeuXaa: 0.0 ± 0.0
Met
1.533MetAla: 1.533 ± 0.198
0.128MetCys: 0.128 ± 0.073
1.073MetAsp: 1.073 ± 0.173
1.866MetGlu: 1.866 ± 0.222
1.099MetPhe: 1.099 ± 0.162
1.048MetGly: 1.048 ± 0.188
0.102MetHis: 0.102 ± 0.048
1.329MetIle: 1.329 ± 0.181
2.223MetLys: 2.223 ± 0.249
2.045MetLeu: 2.045 ± 0.271
0.358MetMet: 0.358 ± 0.086
1.38MetAsn: 1.38 ± 0.197
1.073MetPro: 1.073 ± 0.149
0.946MetGln: 0.946 ± 0.145
1.278MetArg: 1.278 ± 0.149
2.275MetSer: 2.275 ± 0.264
1.917MetThr: 1.917 ± 0.212
1.38MetVal: 1.38 ± 0.223
0.307MetTrp: 0.307 ± 0.086
1.124MetTyr: 1.124 ± 0.201
0.0MetXaa: 0.0 ± 0.0
Asn
2.888AsnAla: 2.888 ± 0.243
0.204AsnCys: 0.204 ± 0.074
2.326AsnAsp: 2.326 ± 0.234
3.731AsnGlu: 3.731 ± 0.321
2.249AsnPhe: 2.249 ± 0.255
3.476AsnGly: 3.476 ± 0.305
0.971AsnHis: 0.971 ± 0.181
4.421AsnIle: 4.421 ± 0.348
5.546AsnLys: 5.546 ± 0.374
4.754AsnLeu: 4.754 ± 0.36
1.789AsnMet: 1.789 ± 0.219
3.399AsnAsn: 3.399 ± 0.317
2.07AsnPro: 2.07 ± 0.253
1.763AsnGln: 1.763 ± 0.182
2.351AsnArg: 2.351 ± 0.236
3.731AsnSer: 3.731 ± 0.318
3.936AsnThr: 3.936 ± 0.319
3.425AsnVal: 3.425 ± 0.297
0.792AsnTrp: 0.792 ± 0.138
2.76AsnTyr: 2.76 ± 0.244
0.0AsnXaa: 0.0 ± 0.0
Pro
1.661ProAla: 1.661 ± 0.309
0.102ProCys: 0.102 ± 0.051
1.891ProAsp: 1.891 ± 0.24
2.377ProGlu: 2.377 ± 0.214
1.252ProPhe: 1.252 ± 0.172
0.46ProGly: 0.46 ± 0.121
0.383ProHis: 0.383 ± 0.09
1.712ProIle: 1.712 ± 0.216
2.811ProLys: 2.811 ± 0.362
2.377ProLeu: 2.377 ± 0.248
0.971ProMet: 0.971 ± 0.157
1.636ProAsn: 1.636 ± 0.203
0.741ProPro: 0.741 ± 0.186
1.278ProGln: 1.278 ± 0.242
0.92ProArg: 0.92 ± 0.168
2.223ProSer: 2.223 ± 0.248
2.249ProThr: 2.249 ± 0.293
1.942ProVal: 1.942 ± 0.315
0.23ProTrp: 0.23 ± 0.068
1.457ProTyr: 1.457 ± 0.237
0.0ProXaa: 0.0 ± 0.0
Gln
2.786GlnAla: 2.786 ± 0.37
0.128GlnCys: 0.128 ± 0.053
1.738GlnAsp: 1.738 ± 0.184
2.811GlnGlu: 2.811 ± 0.286
1.278GlnPhe: 1.278 ± 0.177
2.326GlnGly: 2.326 ± 0.238
0.409GlnHis: 0.409 ± 0.105
1.763GlnIle: 1.763 ± 0.22
2.709GlnLys: 2.709 ± 0.283
3.143GlnLeu: 3.143 ± 0.256
0.792GlnMet: 0.792 ± 0.155
1.278GlnAsn: 1.278 ± 0.167
0.894GlnPro: 0.894 ± 0.319
2.3GlnGln: 2.3 ± 0.893
1.38GlnArg: 1.38 ± 0.213
2.121GlnSer: 2.121 ± 0.285
1.866GlnThr: 1.866 ± 0.202
2.837GlnVal: 2.837 ± 0.268
0.128GlnTrp: 0.128 ± 0.053
1.303GlnTyr: 1.303 ± 0.206
0.0GlnXaa: 0.0 ± 0.0
Arg
2.53ArgAla: 2.53 ± 0.325
0.179ArgCys: 0.179 ± 0.066
2.786ArgAsp: 2.786 ± 0.23
3.731ArgGlu: 3.731 ± 0.336
1.661ArgPhe: 1.661 ± 0.232
2.351ArgGly: 2.351 ± 0.27
0.664ArgHis: 0.664 ± 0.111
2.888ArgIle: 2.888 ± 0.241
3.706ArgLys: 3.706 ± 0.267
3.706ArgLeu: 3.706 ± 0.256
1.048ArgMet: 1.048 ± 0.182
2.683ArgAsn: 2.683 ± 0.303
0.664ArgPro: 0.664 ± 0.133
1.38ArgGln: 1.38 ± 0.19
1.431ArgArg: 1.431 ± 0.202
2.019ArgSer: 2.019 ± 0.216
2.377ArgThr: 2.377 ± 0.303
3.348ArgVal: 3.348 ± 0.291
0.307ArgTrp: 0.307 ± 0.08
1.763ArgTyr: 1.763 ± 0.208
0.0ArgXaa: 0.0 ± 0.0
Ser
3.757SerAla: 3.757 ± 0.312
0.409SerCys: 0.409 ± 0.122
3.731SerAsp: 3.731 ± 0.334
4.498SerGlu: 4.498 ± 0.374
3.016SerPhe: 3.016 ± 0.28
3.603SerGly: 3.603 ± 0.421
1.252SerHis: 1.252 ± 0.158
5.137SerIle: 5.137 ± 0.379
6.159SerLys: 6.159 ± 0.464
6.21SerLeu: 6.21 ± 0.445
1.738SerMet: 1.738 ± 0.218
3.45SerAsn: 3.45 ± 0.261
1.968SerPro: 1.968 ± 0.202
2.147SerGln: 2.147 ± 0.227
3.348SerArg: 3.348 ± 0.311
5.469SerSer: 5.469 ± 0.488
4.242SerThr: 4.242 ± 0.349
4.932SerVal: 4.932 ± 0.365
0.716SerTrp: 0.716 ± 0.148
3.246SerTyr: 3.246 ± 0.284
0.0SerXaa: 0.0 ± 0.0
Thr
4.089ThrAla: 4.089 ± 0.383
0.307ThrCys: 0.307 ± 0.088
3.731ThrAsp: 3.731 ± 0.255
5.035ThrGlu: 5.035 ± 0.325
3.041ThrPhe: 3.041 ± 0.314
4.396ThrGly: 4.396 ± 0.357
1.15ThrHis: 1.15 ± 0.17
4.038ThrIle: 4.038 ± 0.335
4.498ThrLys: 4.498 ± 0.286
5.265ThrLeu: 5.265 ± 0.421
1.201ThrMet: 1.201 ± 0.174
2.939ThrAsn: 2.939 ± 0.262
2.3ThrPro: 2.3 ± 0.219
1.482ThrGln: 1.482 ± 0.183
2.121ThrArg: 2.121 ± 0.272
4.498ThrSer: 4.498 ± 0.296
4.012ThrThr: 4.012 ± 0.293
5.162ThrVal: 5.162 ± 0.39
0.792ThrTrp: 0.792 ± 0.137
2.99ThrTyr: 2.99 ± 0.319
0.0ThrXaa: 0.0 ± 0.0
Val
4.549ValAla: 4.549 ± 0.333
0.46ValCys: 0.46 ± 0.119
4.702ValAsp: 4.702 ± 0.372
5.904ValGlu: 5.904 ± 0.403
2.709ValPhe: 2.709 ± 0.282
3.833ValGly: 3.833 ± 0.303
0.92ValHis: 0.92 ± 0.172
4.958ValIle: 4.958 ± 0.452
5.878ValLys: 5.878 ± 0.439
5.418ValLeu: 5.418 ± 0.42
1.431ValMet: 1.431 ± 0.221
4.115ValAsn: 4.115 ± 0.331
2.326ValPro: 2.326 ± 0.268
2.453ValGln: 2.453 ± 0.227
2.581ValArg: 2.581 ± 0.248
5.571ValSer: 5.571 ± 0.409
5.239ValThr: 5.239 ± 0.47
5.239ValVal: 5.239 ± 0.41
0.613ValTrp: 0.613 ± 0.129
3.22ValTyr: 3.22 ± 0.333
0.0ValXaa: 0.0 ± 0.0
Trp
0.409TrpAla: 0.409 ± 0.095
0.102TrpCys: 0.102 ± 0.046
0.843TrpAsp: 0.843 ± 0.154
0.792TrpGlu: 0.792 ± 0.15
0.383TrpPhe: 0.383 ± 0.101
0.843TrpGly: 0.843 ± 0.166
0.307TrpHis: 0.307 ± 0.086
0.434TrpIle: 0.434 ± 0.089
0.716TrpLys: 0.716 ± 0.15
0.767TrpLeu: 0.767 ± 0.121
0.077TrpMet: 0.077 ± 0.045
0.486TrpAsn: 0.486 ± 0.121
0.0TrpPro: 0.0 ± 0.0
0.281TrpGln: 0.281 ± 0.085
0.256TrpArg: 0.256 ± 0.066
0.486TrpSer: 0.486 ± 0.111
0.716TrpThr: 0.716 ± 0.138
0.741TrpVal: 0.741 ± 0.15
0.256TrpTrp: 0.256 ± 0.087
0.741TrpTyr: 0.741 ± 0.13
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.223TyrAla: 2.223 ± 0.239
0.639TyrCys: 0.639 ± 0.126
2.735TyrAsp: 2.735 ± 0.251
3.578TyrGlu: 3.578 ± 0.268
1.687TyrPhe: 1.687 ± 0.22
2.377TyrGly: 2.377 ± 0.286
0.818TyrHis: 0.818 ± 0.157
3.067TyrIle: 3.067 ± 0.315
3.68TyrLys: 3.68 ± 0.302
3.782TyrLeu: 3.782 ± 0.338
1.15TyrMet: 1.15 ± 0.189
2.658TyrAsn: 2.658 ± 0.231
1.329TyrPro: 1.329 ± 0.181
1.636TyrGln: 1.636 ± 0.276
2.326TyrArg: 2.326 ± 0.202
3.373TyrSer: 3.373 ± 0.327
3.425TyrThr: 3.425 ± 0.311
2.786TyrVal: 2.786 ± 0.285
0.358TyrTrp: 0.358 ± 0.101
2.045TyrTyr: 2.045 ± 0.231
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 184 proteins (39130 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski