Amino acid dipepetide frequency for Synechococcus virus Syn5

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.766AlaAla: 11.766 ± 1.565
0.895AlaCys: 0.895 ± 0.317
5.642AlaAsp: 5.642 ± 0.56
6.812AlaGlu: 6.812 ± 0.772
4.129AlaPhe: 4.129 ± 0.492
8.188AlaGly: 8.188 ± 0.796
1.307AlaHis: 1.307 ± 0.376
5.161AlaIle: 5.161 ± 0.676
3.922AlaLys: 3.922 ± 0.664
8.395AlaLeu: 8.395 ± 0.809
2.064AlaMet: 2.064 ± 0.41
4.266AlaAsn: 4.266 ± 0.498
3.991AlaPro: 3.991 ± 0.486
5.436AlaGln: 5.436 ± 0.774
5.298AlaArg: 5.298 ± 0.92
7.913AlaSer: 7.913 ± 0.943
7.363AlaThr: 7.363 ± 1.24
6.055AlaVal: 6.055 ± 0.752
1.583AlaTrp: 1.583 ± 0.485
2.271AlaTyr: 2.271 ± 0.473
0.0AlaXaa: 0.0 ± 0.0
Cys
0.895CysAla: 0.895 ± 0.207
0.206CysCys: 0.206 ± 0.121
0.275CysAsp: 0.275 ± 0.153
0.413CysGlu: 0.413 ± 0.193
0.482CysPhe: 0.482 ± 0.175
0.688CysGly: 0.688 ± 0.241
0.138CysHis: 0.138 ± 0.093
0.344CysIle: 0.344 ± 0.192
0.55CysLys: 0.55 ± 0.216
0.688CysLeu: 0.688 ± 0.244
0.0CysMet: 0.0 ± 0.0
0.482CysAsn: 0.482 ± 0.259
0.275CysPro: 0.275 ± 0.181
0.344CysGln: 0.344 ± 0.138
0.344CysArg: 0.344 ± 0.178
0.482CysSer: 0.482 ± 0.222
0.826CysThr: 0.826 ± 0.261
0.482CysVal: 0.482 ± 0.204
0.069CysTrp: 0.069 ± 0.072
0.413CysTyr: 0.413 ± 0.189
0.0CysXaa: 0.0 ± 0.0
Asp
6.812AspAla: 6.812 ± 0.625
0.55AspCys: 0.55 ± 0.242
2.89AspAsp: 2.89 ± 0.589
3.647AspGlu: 3.647 ± 0.589
2.546AspPhe: 2.546 ± 0.331
5.161AspGly: 5.161 ± 0.67
0.963AspHis: 0.963 ± 0.316
3.096AspIle: 3.096 ± 0.401
2.202AspLys: 2.202 ± 0.511
7.431AspLeu: 7.431 ± 0.699
1.445AspMet: 1.445 ± 0.324
2.89AspAsn: 2.89 ± 0.371
2.752AspPro: 2.752 ± 0.571
2.133AspGln: 2.133 ± 0.468
3.096AspArg: 3.096 ± 0.512
3.372AspSer: 3.372 ± 0.675
3.853AspThr: 3.853 ± 0.749
4.197AspVal: 4.197 ± 0.468
0.757AspTrp: 0.757 ± 0.245
1.995AspTyr: 1.995 ± 0.393
0.0AspXaa: 0.0 ± 0.0
Glu
7.294GluAla: 7.294 ± 1.017
0.482GluCys: 0.482 ± 0.179
3.784GluAsp: 3.784 ± 0.646
3.716GluGlu: 3.716 ± 0.644
2.202GluPhe: 2.202 ± 0.484
3.44GluGly: 3.44 ± 0.605
1.101GluHis: 1.101 ± 0.303
3.303GluIle: 3.303 ± 0.467
1.583GluLys: 1.583 ± 0.462
6.881GluLeu: 6.881 ± 0.949
1.376GluMet: 1.376 ± 0.275
1.583GluAsn: 1.583 ± 0.383
1.858GluPro: 1.858 ± 0.45
3.028GluGln: 3.028 ± 0.435
3.096GluArg: 3.096 ± 0.553
4.473GluSer: 4.473 ± 0.865
3.509GluThr: 3.509 ± 0.477
3.647GluVal: 3.647 ± 0.532
1.101GluTrp: 1.101 ± 0.402
2.064GluTyr: 2.064 ± 0.492
0.0GluXaa: 0.0 ± 0.0
Phe
2.821PheAla: 2.821 ± 0.411
0.413PheCys: 0.413 ± 0.166
2.959PheAsp: 2.959 ± 0.499
2.064PheGlu: 2.064 ± 0.342
1.789PhePhe: 1.789 ± 0.407
2.615PheGly: 2.615 ± 0.573
0.55PheHis: 0.55 ± 0.269
1.376PheIle: 1.376 ± 0.294
1.583PheLys: 1.583 ± 0.361
2.821PheLeu: 2.821 ± 0.451
0.757PheMet: 0.757 ± 0.211
3.44PheAsn: 3.44 ± 0.477
1.651PhePro: 1.651 ± 0.291
1.651PheGln: 1.651 ± 0.377
1.651PheArg: 1.651 ± 0.358
2.821PheSer: 2.821 ± 0.416
4.197PheThr: 4.197 ± 0.774
2.752PheVal: 2.752 ± 0.542
0.413PheTrp: 0.413 ± 0.197
0.55PheTyr: 0.55 ± 0.213
0.0PheXaa: 0.0 ± 0.0
Gly
5.918GlyAla: 5.918 ± 0.893
0.344GlyCys: 0.344 ± 0.217
5.849GlyAsp: 5.849 ± 0.443
3.853GlyGlu: 3.853 ± 0.585
3.853GlyPhe: 3.853 ± 0.605
6.399GlyGly: 6.399 ± 1.258
1.032GlyHis: 1.032 ± 0.27
3.096GlyIle: 3.096 ± 0.353
3.44GlyLys: 3.44 ± 0.715
6.124GlyLeu: 6.124 ± 0.707
0.895GlyMet: 0.895 ± 0.268
3.853GlyAsn: 3.853 ± 0.565
2.477GlyPro: 2.477 ± 0.38
3.784GlyGln: 3.784 ± 0.427
3.991GlyArg: 3.991 ± 0.587
5.092GlySer: 5.092 ± 0.626
6.881GlyThr: 6.881 ± 1.113
5.161GlyVal: 5.161 ± 0.766
0.963GlyTrp: 0.963 ± 0.3
2.546GlyTyr: 2.546 ± 0.392
0.0GlyXaa: 0.0 ± 0.0
His
1.858HisAla: 1.858 ± 0.325
0.275HisCys: 0.275 ± 0.149
1.032HisAsp: 1.032 ± 0.249
1.032HisGlu: 1.032 ± 0.288
0.413HisPhe: 0.413 ± 0.164
0.826HisGly: 0.826 ± 0.297
0.55HisHis: 0.55 ± 0.276
0.619HisIle: 0.619 ± 0.173
0.688HisLys: 0.688 ± 0.281
2.133HisLeu: 2.133 ± 0.405
0.413HisMet: 0.413 ± 0.189
0.688HisAsn: 0.688 ± 0.268
0.688HisPro: 0.688 ± 0.227
0.963HisGln: 0.963 ± 0.234
0.757HisArg: 0.757 ± 0.263
0.963HisSer: 0.963 ± 0.308
1.032HisThr: 1.032 ± 0.222
0.826HisVal: 0.826 ± 0.251
0.344HisTrp: 0.344 ± 0.172
0.619HisTyr: 0.619 ± 0.2
0.0HisXaa: 0.0 ± 0.0
Ile
4.266IleAla: 4.266 ± 0.496
0.413IleCys: 0.413 ± 0.169
3.578IleAsp: 3.578 ± 0.574
3.578IleGlu: 3.578 ± 0.368
1.789IlePhe: 1.789 ± 0.346
2.821IleGly: 2.821 ± 0.528
1.17IleHis: 1.17 ± 0.355
1.927IleIle: 1.927 ± 0.446
2.89IleLys: 2.89 ± 0.496
2.959IleLeu: 2.959 ± 0.415
1.307IleMet: 1.307 ± 0.345
1.927IleAsn: 1.927 ± 0.36
2.34IlePro: 2.34 ± 0.483
1.651IleGln: 1.651 ± 0.32
2.89IleArg: 2.89 ± 0.577
3.647IleSer: 3.647 ± 0.533
4.748IleThr: 4.748 ± 0.633
2.821IleVal: 2.821 ± 0.497
0.138IleTrp: 0.138 ± 0.107
1.789IleTyr: 1.789 ± 0.266
0.0IleXaa: 0.0 ± 0.0
Lys
6.055LysAla: 6.055 ± 0.87
0.138LysCys: 0.138 ± 0.102
2.271LysAsp: 2.271 ± 0.391
3.234LysGlu: 3.234 ± 0.637
1.445LysPhe: 1.445 ± 0.284
3.44LysGly: 3.44 ± 0.656
0.963LysHis: 0.963 ± 0.229
1.72LysIle: 1.72 ± 0.395
2.615LysLys: 2.615 ± 0.852
4.335LysLeu: 4.335 ± 0.617
1.514LysMet: 1.514 ± 0.348
1.651LysAsn: 1.651 ± 0.391
2.477LysPro: 2.477 ± 0.444
2.064LysGln: 2.064 ± 0.33
2.615LysArg: 2.615 ± 0.533
2.89LysSer: 2.89 ± 0.425
2.271LysThr: 2.271 ± 0.587
2.684LysVal: 2.684 ± 0.404
0.413LysTrp: 0.413 ± 0.181
1.376LysTyr: 1.376 ± 0.351
0.0LysXaa: 0.0 ± 0.0
Leu
8.532LeuAla: 8.532 ± 0.803
0.55LeuCys: 0.55 ± 0.202
5.574LeuAsp: 5.574 ± 0.654
5.78LeuGlu: 5.78 ± 0.72
2.684LeuPhe: 2.684 ± 0.448
5.574LeuGly: 5.574 ± 0.573
1.239LeuHis: 1.239 ± 0.386
4.817LeuIle: 4.817 ± 0.597
4.61LeuLys: 4.61 ± 0.665
5.918LeuLeu: 5.918 ± 0.762
1.858LeuMet: 1.858 ± 0.434
4.404LeuAsn: 4.404 ± 0.489
3.784LeuPro: 3.784 ± 0.742
4.266LeuGln: 4.266 ± 0.516
4.335LeuArg: 4.335 ± 0.733
6.674LeuSer: 6.674 ± 0.618
6.95LeuThr: 6.95 ± 0.76
4.885LeuVal: 4.885 ± 0.667
0.275LeuTrp: 0.275 ± 0.136
2.615LeuTyr: 2.615 ± 0.42
0.0LeuXaa: 0.0 ± 0.0
Met
2.271MetAla: 2.271 ± 0.49
0.413MetCys: 0.413 ± 0.139
1.101MetAsp: 1.101 ± 0.257
1.101MetGlu: 1.101 ± 0.352
0.963MetPhe: 0.963 ± 0.268
1.101MetGly: 1.101 ± 0.256
0.275MetHis: 0.275 ± 0.2
0.826MetIle: 0.826 ± 0.227
1.101MetLys: 1.101 ± 0.278
1.445MetLeu: 1.445 ± 0.351
0.55MetMet: 0.55 ± 0.203
0.55MetAsn: 0.55 ± 0.163
1.789MetPro: 1.789 ± 0.462
0.895MetGln: 0.895 ± 0.284
0.963MetArg: 0.963 ± 0.407
2.202MetSer: 2.202 ± 0.413
1.651MetThr: 1.651 ± 0.36
1.17MetVal: 1.17 ± 0.446
0.138MetTrp: 0.138 ± 0.112
0.619MetTyr: 0.619 ± 0.235
0.0MetXaa: 0.0 ± 0.0
Asn
3.991AsnAla: 3.991 ± 1.157
0.275AsnCys: 0.275 ± 0.173
2.064AsnAsp: 2.064 ± 0.317
2.271AsnGlu: 2.271 ± 0.435
1.995AsnPhe: 1.995 ± 0.424
3.922AsnGly: 3.922 ± 0.648
0.757AsnHis: 0.757 ± 0.226
2.752AsnIle: 2.752 ± 0.621
2.133AsnLys: 2.133 ± 0.456
4.817AsnLeu: 4.817 ± 0.512
1.239AsnMet: 1.239 ± 0.465
2.752AsnAsn: 2.752 ± 0.473
2.546AsnPro: 2.546 ± 0.439
1.72AsnGln: 1.72 ± 0.386
2.821AsnArg: 2.821 ± 0.419
2.546AsnSer: 2.546 ± 0.492
3.44AsnThr: 3.44 ± 0.596
3.647AsnVal: 3.647 ± 0.497
0.619AsnTrp: 0.619 ± 0.209
2.133AsnTyr: 2.133 ± 0.415
0.0AsnXaa: 0.0 ± 0.0
Pro
3.922ProAla: 3.922 ± 0.474
0.206ProCys: 0.206 ± 0.121
2.133ProAsp: 2.133 ± 0.428
3.509ProGlu: 3.509 ± 0.526
1.789ProPhe: 1.789 ± 0.469
2.752ProGly: 2.752 ± 0.572
0.55ProHis: 0.55 ± 0.224
2.133ProIle: 2.133 ± 0.395
2.34ProLys: 2.34 ± 0.5
2.821ProLeu: 2.821 ± 0.426
1.239ProMet: 1.239 ± 0.295
1.927ProAsn: 1.927 ± 0.328
1.101ProPro: 1.101 ± 0.354
2.202ProGln: 2.202 ± 0.359
1.651ProArg: 1.651 ± 0.417
3.096ProSer: 3.096 ± 0.384
2.477ProThr: 2.477 ± 0.349
2.959ProVal: 2.959 ± 0.577
0.413ProTrp: 0.413 ± 0.163
1.032ProTyr: 1.032 ± 0.296
0.0ProXaa: 0.0 ± 0.0
Gln
6.262GlnAla: 6.262 ± 1.0
0.344GlnCys: 0.344 ± 0.168
2.821GlnAsp: 2.821 ± 0.505
2.821GlnGlu: 2.821 ± 0.581
1.583GlnPhe: 1.583 ± 0.343
3.165GlnGly: 3.165 ± 0.4
1.17GlnHis: 1.17 ± 0.295
2.615GlnIle: 2.615 ± 0.463
1.445GlnLys: 1.445 ± 0.316
4.06GlnLeu: 4.06 ± 0.839
1.445GlnMet: 1.445 ± 0.382
1.101GlnAsn: 1.101 ± 0.275
1.376GlnPro: 1.376 ± 0.321
3.716GlnGln: 3.716 ± 0.795
2.477GlnArg: 2.477 ± 0.461
2.615GlnSer: 2.615 ± 0.573
2.477GlnThr: 2.477 ± 0.272
3.234GlnVal: 3.234 ± 0.435
0.757GlnTrp: 0.757 ± 0.298
1.445GlnTyr: 1.445 ± 0.301
0.0GlnXaa: 0.0 ± 0.0
Arg
5.023ArgAla: 5.023 ± 0.746
0.482ArgCys: 0.482 ± 0.214
2.959ArgAsp: 2.959 ± 0.369
3.372ArgGlu: 3.372 ± 0.526
1.583ArgPhe: 1.583 ± 0.263
3.784ArgGly: 3.784 ± 0.483
1.17ArgHis: 1.17 ± 0.298
3.096ArgIle: 3.096 ± 0.367
3.44ArgLys: 3.44 ± 0.572
3.784ArgLeu: 3.784 ± 0.709
0.55ArgMet: 0.55 ± 0.176
2.546ArgAsn: 2.546 ± 0.476
2.133ArgPro: 2.133 ± 0.436
1.995ArgGln: 1.995 ± 0.379
2.34ArgArg: 2.34 ± 0.478
3.922ArgSer: 3.922 ± 0.573
2.89ArgThr: 2.89 ± 0.354
3.165ArgVal: 3.165 ± 0.524
0.55ArgTrp: 0.55 ± 0.191
1.651ArgTyr: 1.651 ± 0.358
0.0ArgXaa: 0.0 ± 0.0
Ser
7.707SerAla: 7.707 ± 1.007
0.55SerCys: 0.55 ± 0.238
5.161SerAsp: 5.161 ± 0.649
3.372SerGlu: 3.372 ± 0.537
3.509SerPhe: 3.509 ± 0.499
6.812SerGly: 6.812 ± 0.957
1.032SerHis: 1.032 ± 0.224
2.546SerIle: 2.546 ± 0.496
3.44SerLys: 3.44 ± 0.472
5.367SerLeu: 5.367 ± 0.889
1.376SerMet: 1.376 ± 0.315
3.303SerAsn: 3.303 ± 0.463
3.096SerPro: 3.096 ± 0.488
3.303SerGln: 3.303 ± 0.612
3.372SerArg: 3.372 ± 0.552
4.541SerSer: 4.541 ± 0.872
4.335SerThr: 4.335 ± 0.646
5.161SerVal: 5.161 ± 1.25
1.239SerTrp: 1.239 ± 0.354
2.271SerTyr: 2.271 ± 0.404
0.0SerXaa: 0.0 ± 0.0
Thr
6.674ThrAla: 6.674 ± 0.848
0.688ThrCys: 0.688 ± 0.244
3.991ThrAsp: 3.991 ± 0.546
3.44ThrGlu: 3.44 ± 0.352
2.615ThrPhe: 2.615 ± 0.383
8.395ThrGly: 8.395 ± 1.016
0.963ThrHis: 0.963 ± 0.31
4.61ThrIle: 4.61 ± 0.738
2.89ThrLys: 2.89 ± 0.408
5.161ThrLeu: 5.161 ± 0.655
1.101ThrMet: 1.101 ± 0.274
4.679ThrAsn: 4.679 ± 1.16
3.234ThrPro: 3.234 ± 0.446
2.546ThrGln: 2.546 ± 0.652
2.89ThrArg: 2.89 ± 0.442
4.197ThrSer: 4.197 ± 0.481
4.748ThrThr: 4.748 ± 0.942
4.404ThrVal: 4.404 ± 0.901
0.826ThrTrp: 0.826 ± 0.188
2.89ThrTyr: 2.89 ± 0.479
0.0ThrXaa: 0.0 ± 0.0
Val
6.537ValAla: 6.537 ± 0.744
0.55ValCys: 0.55 ± 0.236
4.61ValAsp: 4.61 ± 0.61
3.372ValGlu: 3.372 ± 0.703
2.271ValPhe: 2.271 ± 0.374
3.853ValGly: 3.853 ± 0.452
0.963ValHis: 0.963 ± 0.413
2.959ValIle: 2.959 ± 0.441
2.684ValLys: 2.684 ± 0.354
5.642ValLeu: 5.642 ± 0.744
1.17ValMet: 1.17 ± 0.374
3.578ValAsn: 3.578 ± 0.911
1.583ValPro: 1.583 ± 0.324
3.578ValGln: 3.578 ± 0.449
3.165ValArg: 3.165 ± 0.46
5.367ValSer: 5.367 ± 0.651
5.092ValThr: 5.092 ± 0.635
4.541ValVal: 4.541 ± 0.9
0.895ValTrp: 0.895 ± 0.298
1.651ValTyr: 1.651 ± 0.254
0.0ValXaa: 0.0 ± 0.0
Trp
1.376TrpAla: 1.376 ± 0.268
0.275TrpCys: 0.275 ± 0.155
0.688TrpAsp: 0.688 ± 0.179
0.826TrpGlu: 0.826 ± 0.217
0.138TrpPhe: 0.138 ± 0.095
0.619TrpGly: 0.619 ± 0.326
0.413TrpHis: 0.413 ± 0.154
0.55TrpIle: 0.55 ± 0.196
0.826TrpLys: 0.826 ± 0.279
1.789TrpLeu: 1.789 ± 0.354
0.206TrpMet: 0.206 ± 0.104
0.619TrpAsn: 0.619 ± 0.201
0.344TrpPro: 0.344 ± 0.121
0.413TrpGln: 0.413 ± 0.157
0.482TrpArg: 0.482 ± 0.179
0.895TrpSer: 0.895 ± 0.297
0.482TrpThr: 0.482 ± 0.18
0.688TrpVal: 0.688 ± 0.278
0.206TrpTrp: 0.206 ± 0.12
0.138TrpTyr: 0.138 ± 0.102
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.477TyrAla: 2.477 ± 0.329
0.344TyrCys: 0.344 ± 0.218
2.408TyrAsp: 2.408 ± 0.326
1.307TyrGlu: 1.307 ± 0.254
1.101TyrPhe: 1.101 ± 0.282
1.995TyrGly: 1.995 ± 0.348
0.413TyrHis: 0.413 ± 0.152
1.101TyrIle: 1.101 ± 0.217
1.789TyrLys: 1.789 ± 0.533
2.752TyrLeu: 2.752 ± 0.353
0.55TyrMet: 0.55 ± 0.204
2.202TyrAsn: 2.202 ± 0.428
0.826TyrPro: 0.826 ± 0.203
1.239TyrGln: 1.239 ± 0.335
2.202TyrArg: 2.202 ± 0.418
3.784TyrSer: 3.784 ± 0.526
1.72TyrThr: 1.72 ± 0.342
1.583TyrVal: 1.583 ± 0.337
0.275TyrTrp: 0.275 ± 0.146
0.826TyrTyr: 0.826 ± 0.191
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 61 proteins (14534 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski