Amino acid dipepetide frequency for Vibrio sp. V15_P4S5T153

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
6.935AlaAla: 6.935 ± 0.097
0.914AlaCys: 0.914 ± 0.027
4.233AlaAsp: 4.233 ± 0.066
5.061AlaGlu: 5.061 ± 0.068
3.276AlaPhe: 3.276 ± 0.054
5.302AlaGly: 5.302 ± 0.066
1.761AlaHis: 1.761 ± 0.04
5.958AlaIle: 5.958 ± 0.065
5.06AlaLys: 5.06 ± 0.069
9.689AlaLeu: 9.689 ± 0.104
2.555AlaMet: 2.555 ± 0.047
3.587AlaAsn: 3.587 ± 0.056
2.57AlaPro: 2.57 ± 0.046
4.277AlaGln: 4.277 ± 0.065
3.523AlaArg: 3.523 ± 0.051
5.2AlaSer: 5.2 ± 0.063
4.204AlaThr: 4.204 ± 0.054
5.376AlaVal: 5.376 ± 0.074
0.957AlaTrp: 0.957 ± 0.033
2.344AlaTyr: 2.344 ± 0.038
0.0AlaXaa: 0.0 ± 0.0
Cys
0.859CysAla: 0.859 ± 0.029
0.176CysCys: 0.176 ± 0.01
0.662CysAsp: 0.662 ± 0.025
0.692CysGlu: 0.692 ± 0.021
0.506CysPhe: 0.506 ± 0.016
0.992CysGly: 0.992 ± 0.028
0.354CysHis: 0.354 ± 0.017
0.644CysIle: 0.644 ± 0.023
0.566CysLys: 0.566 ± 0.022
1.044CysLeu: 1.044 ± 0.027
0.244CysMet: 0.244 ± 0.013
0.448CysAsn: 0.448 ± 0.02
0.426CysPro: 0.426 ± 0.02
0.512CysGln: 0.512 ± 0.02
0.5CysArg: 0.5 ± 0.019
0.804CysSer: 0.804 ± 0.021
0.49CysThr: 0.49 ± 0.02
0.686CysVal: 0.686 ± 0.023
0.147CysTrp: 0.147 ± 0.011
0.365CysTyr: 0.365 ± 0.016
0.0CysXaa: 0.0 ± 0.0
Asp
4.187AspAla: 4.187 ± 0.059
0.595AspCys: 0.595 ± 0.021
2.949AspAsp: 2.949 ± 0.053
4.0AspGlu: 4.0 ± 0.059
2.585AspPhe: 2.585 ± 0.041
3.631AspGly: 3.631 ± 0.07
1.195AspHis: 1.195 ± 0.029
3.919AspIle: 3.919 ± 0.054
3.41AspLys: 3.41 ± 0.044
5.265AspLeu: 5.265 ± 0.055
1.335AspMet: 1.335 ± 0.029
2.393AspAsn: 2.393 ± 0.046
1.978AspPro: 1.978 ± 0.039
2.009AspGln: 2.009 ± 0.044
2.214AspArg: 2.214 ± 0.037
3.422AspSer: 3.422 ± 0.052
2.391AspThr: 2.391 ± 0.04
3.808AspVal: 3.808 ± 0.048
0.797AspTrp: 0.797 ± 0.028
2.085AspTyr: 2.085 ± 0.041
0.0AspXaa: 0.0 ± 0.0
Glu
5.05GluAla: 5.05 ± 0.066
0.652GluCys: 0.652 ± 0.023
2.687GluAsp: 2.687 ± 0.052
3.855GluGlu: 3.855 ± 0.064
2.705GluPhe: 2.705 ± 0.047
3.352GluGly: 3.352 ± 0.049
1.681GluHis: 1.681 ± 0.035
4.28GluIle: 4.28 ± 0.062
4.162GluLys: 4.162 ± 0.056
7.241GluLeu: 7.241 ± 0.078
1.879GluMet: 1.879 ± 0.037
2.854GluAsn: 2.854 ± 0.046
2.023GluPro: 2.023 ± 0.038
4.054GluGln: 4.054 ± 0.059
3.431GluArg: 3.431 ± 0.049
4.119GluSer: 4.119 ± 0.069
3.077GluThr: 3.077 ± 0.041
4.34GluVal: 4.34 ± 0.061
0.811GluTrp: 0.811 ± 0.027
1.921GluTyr: 1.921 ± 0.036
0.0GluXaa: 0.0 ± 0.0
Phe
3.405PheAla: 3.405 ± 0.051
0.551PheCys: 0.551 ± 0.019
2.789PheAsp: 2.789 ± 0.047
2.781PheGlu: 2.781 ± 0.037
1.73PhePhe: 1.73 ± 0.039
3.046PheGly: 3.046 ± 0.053
0.873PheHis: 0.873 ± 0.024
2.857PheIle: 2.857 ± 0.049
2.176PheLys: 2.176 ± 0.04
3.505PheLeu: 3.505 ± 0.056
1.058PheMet: 1.058 ± 0.027
2.152PheAsn: 2.152 ± 0.04
1.388PhePro: 1.388 ± 0.031
1.33PheGln: 1.33 ± 0.03
1.524PheArg: 1.524 ± 0.034
3.502PheSer: 3.502 ± 0.05
2.333PheThr: 2.333 ± 0.04
2.852PheVal: 2.852 ± 0.052
0.517PheTrp: 0.517 ± 0.02
1.445PheTyr: 1.445 ± 0.034
0.0PheXaa: 0.0 ± 0.0
Gly
4.72GlyAla: 4.72 ± 0.079
0.848GlyCys: 0.848 ± 0.026
3.413GlyAsp: 3.413 ± 0.069
4.251GlyGlu: 4.251 ± 0.064
3.367GlyPhe: 3.367 ± 0.053
4.279GlyGly: 4.279 ± 0.072
1.482GlyHis: 1.482 ± 0.038
4.522GlyIle: 4.522 ± 0.054
3.979GlyLys: 3.979 ± 0.058
6.56GlyLeu: 6.56 ± 0.075
1.899GlyMet: 1.899 ± 0.038
2.589GlyAsn: 2.589 ± 0.063
1.313GlyPro: 1.313 ± 0.038
2.675GlyGln: 2.675 ± 0.053
2.938GlyArg: 2.938 ± 0.047
3.986GlySer: 3.986 ± 0.053
3.103GlyThr: 3.103 ± 0.048
4.901GlyVal: 4.901 ± 0.069
0.948GlyTrp: 0.948 ± 0.03
2.586GlyTyr: 2.586 ± 0.046
0.0GlyXaa: 0.0 ± 0.0
His
1.658HisAla: 1.658 ± 0.035
0.385HisCys: 0.385 ± 0.019
1.205HisAsp: 1.205 ± 0.033
1.213HisGlu: 1.213 ± 0.029
1.195HisPhe: 1.195 ± 0.028
1.523HisGly: 1.523 ± 0.031
0.829HisHis: 0.829 ± 0.028
1.559HisIle: 1.559 ± 0.034
1.147HisLys: 1.147 ± 0.03
2.388HisLeu: 2.388 ± 0.046
0.508HisMet: 0.508 ± 0.018
0.999HisAsn: 0.999 ± 0.028
1.152HisPro: 1.152 ± 0.027
1.305HisGln: 1.305 ± 0.036
1.085HisArg: 1.085 ± 0.025
1.571HisSer: 1.571 ± 0.037
1.134HisThr: 1.134 ± 0.03
1.336HisVal: 1.336 ± 0.031
0.381HisTrp: 0.381 ± 0.019
0.97HisTyr: 0.97 ± 0.027
0.0HisXaa: 0.0 ± 0.0
Ile
6.266IleAla: 6.266 ± 0.076
0.716IleCys: 0.716 ± 0.022
4.401IleAsp: 4.401 ± 0.056
5.235IleGlu: 5.235 ± 0.07
2.329IlePhe: 2.329 ± 0.045
4.533IleGly: 4.533 ± 0.06
1.4IleHis: 1.4 ± 0.033
3.71IleIle: 3.71 ± 0.061
3.682IleLys: 3.682 ± 0.047
5.358IleLeu: 5.358 ± 0.076
1.309IleMet: 1.309 ± 0.031
3.244IleAsn: 3.244 ± 0.049
2.614IlePro: 2.614 ± 0.046
2.459IleGln: 2.459 ± 0.046
2.879IleArg: 2.879 ± 0.044
4.793IleSer: 4.793 ± 0.068
3.785IleThr: 3.785 ± 0.058
4.155IleVal: 4.155 ± 0.054
0.606IleTrp: 0.606 ± 0.022
1.872IleTyr: 1.872 ± 0.038
0.0IleXaa: 0.0 ± 0.0
Lys
4.938LysAla: 4.938 ± 0.065
0.422LysCys: 0.422 ± 0.019
2.772LysAsp: 2.772 ± 0.048
3.961LysGlu: 3.961 ± 0.068
1.827LysPhe: 1.827 ± 0.038
3.473LysGly: 3.473 ± 0.06
1.396LysHis: 1.396 ± 0.032
3.479LysIle: 3.479 ± 0.052
3.507LysLys: 3.507 ± 0.066
5.75LysLeu: 5.75 ± 0.059
1.623LysMet: 1.623 ± 0.036
2.59LysAsn: 2.59 ± 0.05
2.428LysPro: 2.428 ± 0.038
3.041LysGln: 3.041 ± 0.048
2.869LysArg: 2.869 ± 0.045
3.71LysSer: 3.71 ± 0.055
3.094LysThr: 3.094 ± 0.053
3.972LysVal: 3.972 ± 0.055
0.623LysTrp: 0.623 ± 0.022
1.689LysTyr: 1.689 ± 0.036
0.001LysXaa: 0.001 ± 0.001
Leu
9.55LeuAla: 9.55 ± 0.117
1.238LeuCys: 1.238 ± 0.03
5.738LeuAsp: 5.738 ± 0.076
6.245LeuGlu: 6.245 ± 0.075
4.273LeuPhe: 4.273 ± 0.071
6.602LeuGly: 6.602 ± 0.073
2.108LeuHis: 2.108 ± 0.038
6.344LeuIle: 6.344 ± 0.079
5.8LeuLys: 5.8 ± 0.067
10.412LeuLeu: 10.412 ± 0.126
2.767LeuMet: 2.767 ± 0.044
4.96LeuAsn: 4.96 ± 0.062
4.461LeuPro: 4.461 ± 0.056
3.735LeuGln: 3.735 ± 0.062
4.401LeuArg: 4.401 ± 0.063
8.352LeuSer: 8.352 ± 0.082
5.929LeuThr: 5.929 ± 0.07
6.972LeuVal: 6.972 ± 0.081
1.062LeuTrp: 1.062 ± 0.03
2.735LeuTyr: 2.735 ± 0.045
0.0LeuXaa: 0.0 ± 0.0
Met
2.405MetAla: 2.405 ± 0.043
0.227MetCys: 0.227 ± 0.013
1.333MetAsp: 1.333 ± 0.035
1.291MetGlu: 1.291 ± 0.029
0.985MetPhe: 0.985 ± 0.024
1.695MetGly: 1.695 ± 0.041
0.511MetHis: 0.511 ± 0.02
1.663MetIle: 1.663 ± 0.034
1.683MetLys: 1.683 ± 0.033
2.787MetLeu: 2.787 ± 0.044
0.871MetMet: 0.871 ± 0.026
1.329MetAsn: 1.329 ± 0.028
1.158MetPro: 1.158 ± 0.03
1.162MetGln: 1.162 ± 0.028
1.24MetArg: 1.24 ± 0.03
2.004MetSer: 2.004 ± 0.039
1.587MetThr: 1.587 ± 0.033
1.851MetVal: 1.851 ± 0.038
0.219MetTrp: 0.219 ± 0.015
0.588MetTyr: 0.588 ± 0.021
0.0MetXaa: 0.0 ± 0.0
Asn
3.626AsnAla: 3.626 ± 0.052
0.452AsnCys: 0.452 ± 0.018
2.468AsnAsp: 2.468 ± 0.052
2.857AsnGlu: 2.857 ± 0.045
1.574AsnPhe: 1.574 ± 0.037
3.132AsnGly: 3.132 ± 0.055
1.154AsnHis: 1.154 ± 0.025
2.893AsnIle: 2.893 ± 0.043
2.608AsnLys: 2.608 ± 0.052
4.148AsnLeu: 4.148 ± 0.057
1.046AsnMet: 1.046 ± 0.028
2.105AsnAsn: 2.105 ± 0.044
2.202AsnPro: 2.202 ± 0.043
2.361AsnGln: 2.361 ± 0.042
2.084AsnArg: 2.084 ± 0.041
2.784AsnSer: 2.784 ± 0.048
2.199AsnThr: 2.199 ± 0.044
2.797AsnVal: 2.797 ± 0.048
0.519AsnTrp: 0.519 ± 0.018
1.425AsnTyr: 1.425 ± 0.034
0.0AsnXaa: 0.0 ± 0.0
Pro
2.711ProAla: 2.711 ± 0.04
0.359ProCys: 0.359 ± 0.015
2.125ProAsp: 2.125 ± 0.044
2.864ProGlu: 2.864 ± 0.048
1.677ProPhe: 1.677 ± 0.033
1.819ProGly: 1.819 ± 0.033
0.91ProHis: 0.91 ± 0.025
2.601ProIle: 2.601 ± 0.045
2.086ProLys: 2.086 ± 0.036
3.954ProLeu: 3.954 ± 0.063
1.049ProMet: 1.049 ± 0.026
1.736ProAsn: 1.736 ± 0.037
1.03ProPro: 1.03 ± 0.031
1.747ProGln: 1.747 ± 0.035
1.311ProArg: 1.311 ± 0.033
2.505ProSer: 2.505 ± 0.043
2.084ProThr: 2.084 ± 0.036
2.655ProVal: 2.655 ± 0.044
0.446ProTrp: 0.446 ± 0.016
1.263ProTyr: 1.263 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
4.477GlnAla: 4.477 ± 0.071
0.478GlnCys: 0.478 ± 0.02
2.014GlnAsp: 2.014 ± 0.039
2.629GlnGlu: 2.629 ± 0.046
1.81GlnPhe: 1.81 ± 0.038
3.04GlnGly: 3.04 ± 0.054
1.279GlnHis: 1.279 ± 0.032
2.763GlnIle: 2.763 ± 0.051
2.362GlnLys: 2.362 ± 0.043
5.18GlnLeu: 5.18 ± 0.073
1.19GlnMet: 1.19 ± 0.029
1.73GlnAsn: 1.73 ± 0.04
1.702GlnPro: 1.702 ± 0.045
3.157GlnGln: 3.157 ± 0.067
2.454GlnArg: 2.454 ± 0.048
2.89GlnSer: 2.89 ± 0.051
2.269GlnThr: 2.269 ± 0.045
3.13GlnVal: 3.13 ± 0.047
0.723GlnTrp: 0.723 ± 0.027
1.586GlnTyr: 1.586 ± 0.036
0.0GlnXaa: 0.0 ± 0.0
Arg
3.289ArgAla: 3.289 ± 0.045
0.515ArgCys: 0.515 ± 0.018
2.511ArgAsp: 2.511 ± 0.051
2.998ArgGlu: 2.998 ± 0.054
2.236ArgPhe: 2.236 ± 0.037
2.481ArgGly: 2.481 ± 0.048
1.148ArgHis: 1.148 ± 0.03
3.064ArgIle: 3.064 ± 0.049
2.551ArgLys: 2.551 ± 0.048
4.899ArgLeu: 4.899 ± 0.071
1.187ArgMet: 1.187 ± 0.029
1.986ArgAsn: 1.986 ± 0.041
1.464ArgPro: 1.464 ± 0.035
2.065ArgGln: 2.065 ± 0.038
2.211ArgArg: 2.211 ± 0.049
2.784ArgSer: 2.784 ± 0.041
2.115ArgThr: 2.115 ± 0.042
3.062ArgVal: 3.062 ± 0.046
0.595ArgTrp: 0.595 ± 0.024
1.799ArgTyr: 1.799 ± 0.036
0.0ArgXaa: 0.0 ± 0.0
Ser
5.401SerAla: 5.401 ± 0.066
0.671SerCys: 0.671 ± 0.019
3.871SerAsp: 3.871 ± 0.056
4.404SerGlu: 4.404 ± 0.057
2.987SerPhe: 2.987 ± 0.043
4.749SerGly: 4.749 ± 0.052
1.655SerHis: 1.655 ± 0.035
4.517SerIle: 4.517 ± 0.069
3.76SerLys: 3.76 ± 0.055
7.37SerLeu: 7.37 ± 0.084
1.902SerMet: 1.902 ± 0.035
2.919SerAsn: 2.919 ± 0.057
2.344SerPro: 2.344 ± 0.036
3.179SerGln: 3.179 ± 0.045
2.913SerArg: 2.913 ± 0.047
4.716SerSer: 4.716 ± 0.061
3.327SerThr: 3.327 ± 0.048
4.691SerVal: 4.691 ± 0.056
0.75SerTrp: 0.75 ± 0.024
2.225SerTyr: 2.225 ± 0.036
0.0SerXaa: 0.0 ± 0.0
Thr
4.161ThrAla: 4.161 ± 0.067
0.512ThrCys: 0.512 ± 0.021
2.66ThrAsp: 2.66 ± 0.046
3.034ThrGlu: 3.034 ± 0.044
2.014ThrPhe: 2.014 ± 0.04
3.536ThrGly: 3.536 ± 0.057
1.336ThrHis: 1.336 ± 0.031
3.441ThrIle: 3.441 ± 0.052
2.585ThrLys: 2.585 ± 0.051
6.246ThrLeu: 6.246 ± 0.076
1.142ThrMet: 1.142 ± 0.029
2.034ThrAsn: 2.034 ± 0.035
2.53ThrPro: 2.53 ± 0.04
2.501ThrGln: 2.501 ± 0.05
2.167ThrArg: 2.167 ± 0.04
3.302ThrSer: 3.302 ± 0.056
2.778ThrThr: 2.778 ± 0.051
3.679ThrVal: 3.679 ± 0.062
0.538ThrTrp: 0.538 ± 0.02
1.513ThrTyr: 1.513 ± 0.029
0.001ThrXaa: 0.001 ± 0.001
Val
5.967ValAla: 5.967 ± 0.066
0.803ValCys: 0.803 ± 0.025
3.99ValAsp: 3.99 ± 0.058
4.595ValGlu: 4.595 ± 0.064
2.749ValPhe: 2.749 ± 0.043
4.404ValGly: 4.404 ± 0.067
1.243ValHis: 1.243 ± 0.03
4.698ValIle: 4.698 ± 0.065
3.89ValLys: 3.89 ± 0.055
6.622ValLeu: 6.622 ± 0.08
2.028ValMet: 2.028 ± 0.035
3.028ValAsn: 3.028 ± 0.054
2.386ValPro: 2.386 ± 0.047
2.351ValGln: 2.351 ± 0.04
2.889ValArg: 2.889 ± 0.047
4.941ValSer: 4.941 ± 0.06
3.829ValThr: 3.829 ± 0.061
5.193ValVal: 5.193 ± 0.061
0.746ValTrp: 0.746 ± 0.023
1.854ValTyr: 1.854 ± 0.044
0.001ValXaa: 0.001 ± 0.001
Trp
0.814TrpAla: 0.814 ± 0.024
0.156TrpCys: 0.156 ± 0.011
0.599TrpAsp: 0.599 ± 0.022
0.543TrpGlu: 0.543 ± 0.023
0.584TrpPhe: 0.584 ± 0.022
0.708TrpGly: 0.708 ± 0.024
0.365TrpHis: 0.365 ± 0.016
0.686TrpIle: 0.686 ± 0.025
0.589TrpLys: 0.589 ± 0.019
1.69TrpLeu: 1.69 ± 0.039
0.332TrpMet: 0.332 ± 0.017
0.501TrpAsn: 0.501 ± 0.022
0.411TrpPro: 0.411 ± 0.016
0.893TrpGln: 0.893 ± 0.028
0.618TrpArg: 0.618 ± 0.022
0.707TrpSer: 0.707 ± 0.024
0.453TrpThr: 0.453 ± 0.02
0.862TrpVal: 0.862 ± 0.029
0.18TrpTrp: 0.18 ± 0.012
0.372TrpTyr: 0.372 ± 0.016
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.361TyrAla: 2.361 ± 0.041
0.447TyrCys: 0.447 ± 0.018
1.75TyrAsp: 1.75 ± 0.043
1.665TyrGlu: 1.665 ± 0.036
1.407TyrPhe: 1.407 ± 0.031
2.062TyrGly: 2.062 ± 0.038
0.863TyrHis: 0.863 ± 0.028
1.749TyrIle: 1.749 ± 0.035
1.562TyrLys: 1.562 ± 0.035
3.575TyrLeu: 3.575 ± 0.055
0.663TyrMet: 0.663 ± 0.024
1.251TyrAsn: 1.251 ± 0.033
1.35TyrPro: 1.35 ± 0.029
2.048TyrGln: 2.048 ± 0.044
1.707TyrArg: 1.707 ± 0.034
2.257TyrSer: 2.257 ± 0.044
1.53TyrThr: 1.53 ± 0.038
1.888TyrVal: 1.888 ± 0.034
0.501TyrTrp: 0.501 ± 0.02
1.104TyrTyr: 1.104 ± 0.028
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.001XaaAla: 0.001 ± 0.001
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.001XaaPhe: 0.001 ± 0.001
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.001XaaArg: 0.001 ± 0.001
0.0XaaSer: 0.0 ± 0.0
0.001XaaThr: 0.001 ± 0.001
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4788 proteins (1438149 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski