Amino acid dipepetide frequency for Rothia aeria

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
15.206AlaAla: 15.206 ± 0.219
0.852AlaCys: 0.852 ± 0.035
6.108AlaAsp: 6.108 ± 0.11
7.633AlaGlu: 7.633 ± 0.125
3.296AlaPhe: 3.296 ± 0.075
9.388AlaGly: 9.388 ± 0.153
2.882AlaHis: 2.882 ± 0.069
4.695AlaIle: 4.695 ± 0.096
4.004AlaLys: 4.004 ± 0.1
11.286AlaLeu: 11.286 ± 0.163
2.431AlaMet: 2.431 ± 0.067
3.087AlaAsn: 3.087 ± 0.082
5.863AlaPro: 5.863 ± 0.121
5.217AlaGln: 5.217 ± 0.121
7.007AlaArg: 7.007 ± 0.122
6.882AlaSer: 6.882 ± 0.126
5.543AlaThr: 5.543 ± 0.091
8.32AlaVal: 8.32 ± 0.143
1.323AlaTrp: 1.323 ± 0.044
2.691AlaTyr: 2.691 ± 0.06
0.0AlaXaa: 0.0 ± 0.0
Cys
1.013CysAla: 1.013 ± 0.047
0.186CysCys: 0.186 ± 0.018
0.362CysAsp: 0.362 ± 0.023
0.396CysGlu: 0.396 ± 0.025
0.281CysPhe: 0.281 ± 0.018
0.852CysGly: 0.852 ± 0.038
0.134CysHis: 0.134 ± 0.015
0.362CysIle: 0.362 ± 0.026
0.145CysLys: 0.145 ± 0.013
0.738CysLeu: 0.738 ± 0.031
0.191CysMet: 0.191 ± 0.018
0.156CysAsn: 0.156 ± 0.015
0.392CysPro: 0.392 ± 0.025
0.181CysGln: 0.181 ± 0.016
0.484CysArg: 0.484 ± 0.033
0.627CysSer: 0.627 ± 0.033
0.672CysThr: 0.672 ± 0.039
0.604CysVal: 0.604 ± 0.034
0.196CysTrp: 0.196 ± 0.018
0.222CysTyr: 0.222 ± 0.019
0.0CysXaa: 0.0 ± 0.0
Asp
6.446AspAla: 6.446 ± 0.11
0.269AspCys: 0.269 ± 0.019
2.688AspAsp: 2.688 ± 0.07
3.992AspGlu: 3.992 ± 0.092
2.052AspPhe: 2.052 ± 0.072
4.56AspGly: 4.56 ± 0.09
0.909AspHis: 0.909 ± 0.046
2.709AspIle: 2.709 ± 0.068
1.88AspLys: 1.88 ± 0.062
4.179AspLeu: 4.179 ± 0.088
1.136AspMet: 1.136 ± 0.044
1.511AspAsn: 1.511 ± 0.052
3.074AspPro: 3.074 ± 0.075
1.285AspGln: 1.285 ± 0.042
2.763AspArg: 2.763 ± 0.069
3.084AspSer: 3.084 ± 0.066
3.279AspThr: 3.279 ± 0.076
3.555AspVal: 3.555 ± 0.093
0.7AspTrp: 0.7 ± 0.037
1.735AspTyr: 1.735 ± 0.054
0.0AspXaa: 0.0 ± 0.0
Glu
6.636GluAla: 6.636 ± 0.124
0.364GluCys: 0.364 ± 0.024
3.274GluAsp: 3.274 ± 0.077
4.096GluGlu: 4.096 ± 0.101
1.969GluPhe: 1.969 ± 0.056
4.384GluGly: 4.384 ± 0.086
2.055GluHis: 2.055 ± 0.057
2.925GluIle: 2.925 ± 0.066
2.795GluLys: 2.795 ± 0.066
6.268GluLeu: 6.268 ± 0.104
1.117GluMet: 1.117 ± 0.045
2.377GluAsn: 2.377 ± 0.065
3.116GluPro: 3.116 ± 0.075
3.208GluGln: 3.208 ± 0.075
4.559GluArg: 4.559 ± 0.1
3.201GluSer: 3.201 ± 0.073
3.365GluThr: 3.365 ± 0.078
4.191GluVal: 4.191 ± 0.088
0.68GluTrp: 0.68 ± 0.033
2.0GluTyr: 2.0 ± 0.058
0.0GluXaa: 0.0 ± 0.0
Phe
3.539PheAla: 3.539 ± 0.073
0.349PheCys: 0.349 ± 0.022
1.947PheAsp: 1.947 ± 0.058
1.988PheGlu: 1.988 ± 0.053
1.413PhePhe: 1.413 ± 0.056
3.045PheGly: 3.045 ± 0.082
0.5PheHis: 0.5 ± 0.03
1.637PheIle: 1.637 ± 0.06
1.045PheLys: 1.045 ± 0.04
2.695PheLeu: 2.695 ± 0.068
0.871PheMet: 0.871 ± 0.043
1.071PheAsn: 1.071 ± 0.045
1.359PhePro: 1.359 ± 0.04
0.675PheGln: 0.675 ± 0.03
1.563PheArg: 1.563 ± 0.045
2.464PheSer: 2.464 ± 0.082
2.659PheThr: 2.659 ± 0.07
2.302PheVal: 2.302 ± 0.062
0.484PheTrp: 0.484 ± 0.029
1.08PheTyr: 1.08 ± 0.046
0.0PheXaa: 0.0 ± 0.0
Gly
8.941GlyAla: 8.941 ± 0.129
0.855GlyCys: 0.855 ± 0.043
3.723GlyAsp: 3.723 ± 0.084
5.107GlyGlu: 5.107 ± 0.092
3.002GlyPhe: 3.002 ± 0.078
6.861GlyGly: 6.861 ± 0.204
1.685GlyHis: 1.685 ± 0.051
4.289GlyIle: 4.289 ± 0.102
3.42GlyLys: 3.42 ± 0.071
6.683GlyLeu: 6.683 ± 0.097
2.131GlyMet: 2.131 ± 0.063
2.309GlyAsn: 2.309 ± 0.083
2.749GlyPro: 2.749 ± 0.074
2.861GlyGln: 2.861 ± 0.089
4.515GlyArg: 4.515 ± 0.088
5.702GlySer: 5.702 ± 0.126
5.819GlyThr: 5.819 ± 0.099
6.697GlyVal: 6.697 ± 0.117
1.316GlyTrp: 1.316 ± 0.05
2.707GlyTyr: 2.707 ± 0.075
0.0GlyXaa: 0.0 ± 0.0
His
2.293HisAla: 2.293 ± 0.069
0.181HisCys: 0.181 ± 0.016
1.164HisAsp: 1.164 ± 0.039
1.434HisGlu: 1.434 ± 0.046
0.583HisPhe: 0.583 ± 0.029
1.843HisGly: 1.843 ± 0.054
0.588HisHis: 0.588 ± 0.029
1.0HisIle: 1.0 ± 0.035
0.721HisLys: 0.721 ± 0.033
2.134HisLeu: 2.134 ± 0.06
0.566HisMet: 0.566 ± 0.028
0.731HisAsn: 0.731 ± 0.034
1.712HisPro: 1.712 ± 0.055
0.775HisGln: 0.775 ± 0.032
1.679HisArg: 1.679 ± 0.048
1.288HisSer: 1.288 ± 0.043
1.565HisThr: 1.565 ± 0.055
1.432HisVal: 1.432 ± 0.043
0.284HisTrp: 0.284 ± 0.023
0.684HisTyr: 0.684 ± 0.035
0.0HisXaa: 0.0 ± 0.0
Ile
5.791IleAla: 5.791 ± 0.097
0.415IleCys: 0.415 ± 0.029
2.973IleAsp: 2.973 ± 0.065
3.058IleGlu: 3.058 ± 0.072
1.748IlePhe: 1.748 ± 0.06
3.781IleGly: 3.781 ± 0.102
0.985IleHis: 0.985 ± 0.033
2.624IleIle: 2.624 ± 0.067
1.494IleLys: 1.494 ± 0.05
4.517IleLeu: 4.517 ± 0.091
1.114IleMet: 1.114 ± 0.044
1.47IleAsn: 1.47 ± 0.052
2.913IlePro: 2.913 ± 0.074
1.218IleGln: 1.218 ± 0.045
2.792IleArg: 2.792 ± 0.067
3.138IleSer: 3.138 ± 0.079
3.284IleThr: 3.284 ± 0.079
3.648IleVal: 3.648 ± 0.075
0.52IleTrp: 0.52 ± 0.026
1.234IleTyr: 1.234 ± 0.053
0.0IleXaa: 0.0 ± 0.0
Lys
3.641LysAla: 3.641 ± 0.093
0.159LysCys: 0.159 ± 0.014
2.043LysAsp: 2.043 ± 0.064
2.016LysGlu: 2.016 ± 0.061
1.038LysPhe: 1.038 ± 0.046
2.388LysGly: 2.388 ± 0.078
0.864LysHis: 0.864 ± 0.035
2.008LysIle: 2.008 ± 0.059
2.029LysLys: 2.029 ± 0.072
3.151LysLeu: 3.151 ± 0.079
0.851LysMet: 0.851 ± 0.035
1.736LysAsn: 1.736 ± 0.06
2.195LysPro: 2.195 ± 0.074
1.181LysGln: 1.181 ± 0.044
2.13LysArg: 2.13 ± 0.059
2.07LysSer: 2.07 ± 0.057
2.54LysThr: 2.54 ± 0.054
2.691LysVal: 2.691 ± 0.069
0.351LysTrp: 0.351 ± 0.022
1.058LysTyr: 1.058 ± 0.042
0.0LysXaa: 0.0 ± 0.0
Leu
10.76LeuAla: 10.76 ± 0.141
0.854LeuCys: 0.854 ± 0.042
5.09LeuAsp: 5.09 ± 0.096
5.246LeuGlu: 5.246 ± 0.095
2.897LeuPhe: 2.897 ± 0.073
7.727LeuGly: 7.727 ± 0.119
1.988LeuHis: 1.988 ± 0.05
4.634LeuIle: 4.634 ± 0.084
3.262LeuLys: 3.262 ± 0.072
8.932LeuLeu: 8.932 ± 0.158
2.302LeuMet: 2.302 ± 0.062
3.148LeuAsn: 3.148 ± 0.079
5.082LeuPro: 5.082 ± 0.099
2.627LeuGln: 2.627 ± 0.069
5.889LeuArg: 5.889 ± 0.109
6.122LeuSer: 6.122 ± 0.096
6.161LeuThr: 6.161 ± 0.103
6.93LeuVal: 6.93 ± 0.124
1.327LeuTrp: 1.327 ± 0.046
2.387LeuTyr: 2.387 ± 0.067
0.0LeuXaa: 0.0 ± 0.0
Met
2.324MetAla: 2.324 ± 0.061
0.222MetCys: 0.222 ± 0.021
0.963MetAsp: 0.963 ± 0.039
0.922MetGlu: 0.922 ± 0.038
0.705MetPhe: 0.705 ± 0.034
1.839MetGly: 1.839 ± 0.052
0.504MetHis: 0.504 ± 0.029
1.098MetIle: 1.098 ± 0.041
0.823MetLys: 0.823 ± 0.035
2.323MetLeu: 2.323 ± 0.064
0.569MetMet: 0.569 ± 0.031
0.857MetAsn: 0.857 ± 0.036
1.275MetPro: 1.275 ± 0.043
0.747MetGln: 0.747 ± 0.033
1.821MetArg: 1.821 ± 0.05
1.829MetSer: 1.829 ± 0.052
1.492MetThr: 1.492 ± 0.043
1.731MetVal: 1.731 ± 0.048
0.253MetTrp: 0.253 ± 0.02
0.526MetTyr: 0.526 ± 0.029
0.0MetXaa: 0.0 ± 0.0
Asn
3.312AsnAla: 3.312 ± 0.114
0.191AsnCys: 0.191 ± 0.02
1.468AsnAsp: 1.468 ± 0.048
1.646AsnGlu: 1.646 ± 0.047
0.972AsnPhe: 0.972 ± 0.04
2.665AsnGly: 2.665 ± 0.073
0.61AsnHis: 0.61 ± 0.029
1.798AsnIle: 1.798 ± 0.053
1.025AsnLys: 1.025 ± 0.042
2.928AsnLeu: 2.928 ± 0.075
0.691AsnMet: 0.691 ± 0.034
1.318AsnAsn: 1.318 ± 0.06
2.461AsnPro: 2.461 ± 0.065
1.044AsnGln: 1.044 ± 0.055
1.874AsnArg: 1.874 ± 0.049
1.9AsnSer: 1.9 ± 0.052
2.435AsnThr: 2.435 ± 0.061
2.065AsnVal: 2.065 ± 0.049
0.43AsnTrp: 0.43 ± 0.026
0.887AsnTyr: 0.887 ± 0.041
0.0AsnXaa: 0.0 ± 0.0
Pro
6.578ProAla: 6.578 ± 0.128
0.343ProCys: 0.343 ± 0.025
3.011ProAsp: 3.011 ± 0.068
4.087ProGlu: 4.087 ± 0.097
1.545ProPhe: 1.545 ± 0.053
4.208ProGly: 4.208 ± 0.068
1.463ProHis: 1.463 ± 0.047
2.024ProIle: 2.024 ± 0.055
1.946ProLys: 1.946 ± 0.077
4.534ProLeu: 4.534 ± 0.079
1.041ProMet: 1.041 ± 0.039
1.649ProAsn: 1.649 ± 0.064
2.027ProPro: 2.027 ± 0.073
2.491ProGln: 2.491 ± 0.076
2.763ProArg: 2.763 ± 0.068
3.387ProSer: 3.387 ± 0.075
3.444ProThr: 3.444 ± 0.119
4.569ProVal: 4.569 ± 0.079
0.633ProTrp: 0.633 ± 0.029
1.316ProTyr: 1.316 ± 0.046
0.0ProXaa: 0.0 ± 0.0
Gln
4.151GlnAla: 4.151 ± 0.086
0.175GlnCys: 0.175 ± 0.019
1.703GlnAsp: 1.703 ± 0.054
2.193GlnGlu: 2.193 ± 0.06
0.924GlnPhe: 0.924 ± 0.039
2.622GlnGly: 2.622 ± 0.094
0.865GlnHis: 0.865 ± 0.035
1.612GlnIle: 1.612 ± 0.05
1.628GlnLys: 1.628 ± 0.058
3.495GlnLeu: 3.495 ± 0.068
0.857GlnMet: 0.857 ± 0.037
1.367GlnAsn: 1.367 ± 0.051
1.891GlnPro: 1.891 ± 0.101
2.266GlnGln: 2.266 ± 0.125
2.409GlnArg: 2.409 ± 0.059
1.647GlnSer: 1.647 ± 0.075
1.846GlnThr: 1.846 ± 0.047
2.866GlnVal: 2.866 ± 0.063
0.479GlnTrp: 0.479 ± 0.028
1.016GlnTyr: 1.016 ± 0.045
0.0GlnXaa: 0.0 ± 0.0
Arg
6.838ArgAla: 6.838 ± 0.113
0.577ArgCys: 0.577 ± 0.027
2.961ArgAsp: 2.961 ± 0.067
4.408ArgGlu: 4.408 ± 0.083
1.959ArgPhe: 1.959 ± 0.055
4.509ArgGly: 4.509 ± 0.084
1.295ArgHis: 1.295 ± 0.046
3.55ArgIle: 3.55 ± 0.074
2.206ArgLys: 2.206 ± 0.06
5.614ArgLeu: 5.614 ± 0.095
1.725ArgMet: 1.725 ± 0.048
1.767ArgAsn: 1.767 ± 0.056
2.754ArgPro: 2.754 ± 0.072
2.203ArgGln: 2.203 ± 0.063
4.748ArgArg: 4.748 ± 0.103
3.647ArgSer: 3.647 ± 0.074
4.021ArgThr: 4.021 ± 0.082
4.736ArgVal: 4.736 ± 0.085
1.071ArgTrp: 1.071 ± 0.042
1.934ArgTyr: 1.934 ± 0.054
0.0ArgXaa: 0.0 ± 0.0
Ser
7.272SerAla: 7.272 ± 0.107
0.531SerCys: 0.531 ± 0.033
2.844SerAsp: 2.844 ± 0.062
3.545SerGlu: 3.545 ± 0.079
2.087SerPhe: 2.087 ± 0.066
5.939SerGly: 5.939 ± 0.112
1.286SerHis: 1.286 ± 0.044
2.929SerIle: 2.929 ± 0.069
1.944SerLys: 1.944 ± 0.059
5.59SerLeu: 5.59 ± 0.094
1.46SerMet: 1.46 ± 0.047
1.745SerAsn: 1.745 ± 0.052
3.495SerPro: 3.495 ± 0.084
2.068SerGln: 2.068 ± 0.081
3.74SerArg: 3.74 ± 0.085
4.62SerSer: 4.62 ± 0.113
4.024SerThr: 4.024 ± 0.079
4.609SerVal: 4.609 ± 0.088
0.985SerTrp: 0.985 ± 0.044
1.811SerTyr: 1.811 ± 0.052
0.0SerXaa: 0.0 ± 0.0
Thr
6.873ThrAla: 6.873 ± 0.111
0.462ThrCys: 0.462 ± 0.026
3.346ThrAsp: 3.346 ± 0.076
3.863ThrGlu: 3.863 ± 0.081
1.951ThrPhe: 1.951 ± 0.054
5.737ThrGly: 5.737 ± 0.09
1.557ThrHis: 1.557 ± 0.049
2.958ThrIle: 2.958 ± 0.074
1.929ThrLys: 1.929 ± 0.052
6.075ThrLeu: 6.075 ± 0.093
1.25ThrMet: 1.25 ± 0.042
1.739ThrAsn: 1.739 ± 0.052
4.313ThrPro: 4.313 ± 0.142
1.957ThrGln: 1.957 ± 0.058
3.603ThrArg: 3.603 ± 0.071
3.491ThrSer: 3.491 ± 0.08
3.477ThrThr: 3.477 ± 0.079
5.717ThrVal: 5.717 ± 0.098
0.81ThrTrp: 0.81 ± 0.037
1.747ThrTyr: 1.747 ± 0.072
0.0ThrXaa: 0.0 ± 0.0
Val
7.791ValAla: 7.791 ± 0.113
0.735ValCys: 0.735 ± 0.033
3.873ValAsp: 3.873 ± 0.088
4.414ValGlu: 4.414 ± 0.09
2.76ValPhe: 2.76 ± 0.069
5.426ValGly: 5.426 ± 0.101
1.703ValHis: 1.703 ± 0.055
4.046ValIle: 4.046 ± 0.087
2.593ValLys: 2.593 ± 0.074
7.93ValLeu: 7.93 ± 0.15
1.564ValMet: 1.564 ± 0.047
2.524ValAsn: 2.524 ± 0.068
4.381ValPro: 4.381 ± 0.088
2.589ValGln: 2.589 ± 0.065
5.055ValArg: 5.055 ± 0.084
4.888ValSer: 4.888 ± 0.078
4.67ValThr: 4.67 ± 0.089
5.936ValVal: 5.936 ± 0.121
0.896ValTrp: 0.896 ± 0.043
1.921ValTyr: 1.921 ± 0.059
0.0ValXaa: 0.0 ± 0.0
Trp
1.438TrpAla: 1.438 ± 0.046
0.205TrpCys: 0.205 ± 0.017
0.772TrpAsp: 0.772 ± 0.033
0.76TrpGlu: 0.76 ± 0.033
0.513TrpPhe: 0.513 ± 0.029
1.099TrpGly: 1.099 ± 0.044
0.284TrpHis: 0.284 ± 0.021
0.582TrpIle: 0.582 ± 0.027
0.376TrpLys: 0.376 ± 0.023
1.44TrpLeu: 1.44 ± 0.05
0.418TrpMet: 0.418 ± 0.026
0.37TrpAsn: 0.37 ± 0.023
0.472TrpPro: 0.472 ± 0.031
0.498TrpGln: 0.498 ± 0.027
0.978TrpArg: 0.978 ± 0.043
0.737TrpSer: 0.737 ± 0.032
0.626TrpThr: 0.626 ± 0.035
1.216TrpVal: 1.216 ± 0.038
0.304TrpTrp: 0.304 ± 0.019
0.362TrpTyr: 0.362 ± 0.024
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.871TyrAla: 2.871 ± 0.054
0.269TyrCys: 0.269 ± 0.019
1.491TyrAsp: 1.491 ± 0.049
1.774TyrGlu: 1.774 ± 0.062
0.992TyrPhe: 0.992 ± 0.042
2.499TyrGly: 2.499 ± 0.069
0.498TyrHis: 0.498 ± 0.027
1.238TyrIle: 1.238 ± 0.045
0.878TyrLys: 0.878 ± 0.034
2.853TyrLeu: 2.853 ± 0.071
0.536TyrMet: 0.536 ± 0.029
0.785TyrAsn: 0.785 ± 0.032
1.532TyrPro: 1.532 ± 0.051
0.924TyrGln: 0.924 ± 0.051
2.153TyrArg: 2.153 ± 0.063
1.804TyrSer: 1.804 ± 0.047
1.932TyrThr: 1.932 ± 0.052
1.878TyrVal: 1.878 ± 0.054
0.408TyrTrp: 0.408 ± 0.028
0.788TyrTyr: 0.788 ± 0.031
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2797 proteins (684140 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski