Amino acid dipepetide frequency for Haloterrigena sp. YPL8

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
11.465AlaAla: 11.465 ± 0.154
0.685AlaCys: 0.685 ± 0.029
9.195AlaAsp: 9.195 ± 0.11
7.566AlaGlu: 7.566 ± 0.089
3.731AlaPhe: 3.731 ± 0.06
8.592AlaGly: 8.592 ± 0.104
1.726AlaHis: 1.726 ± 0.045
5.667AlaIle: 5.667 ± 0.088
1.772AlaLys: 1.772 ± 0.041
9.249AlaLeu: 9.249 ± 0.118
1.969AlaMet: 1.969 ± 0.041
2.633AlaAsn: 2.633 ± 0.051
3.406AlaPro: 3.406 ± 0.058
2.078AlaGln: 2.078 ± 0.038
5.62AlaArg: 5.62 ± 0.086
5.31AlaSer: 5.31 ± 0.082
6.901AlaThr: 6.901 ± 0.085
9.43AlaVal: 9.43 ± 0.125
0.993AlaTrp: 0.993 ± 0.029
2.529AlaTyr: 2.529 ± 0.051
0.0AlaXaa: 0.0 ± 0.0
Cys
0.586CysAla: 0.586 ± 0.024
0.104CysCys: 0.104 ± 0.01
0.666CysAsp: 0.666 ± 0.025
0.655CysGlu: 0.655 ± 0.024
0.217CysPhe: 0.217 ± 0.012
0.863CysGly: 0.863 ± 0.034
0.206CysHis: 0.206 ± 0.014
0.285CysIle: 0.285 ± 0.016
0.163CysLys: 0.163 ± 0.012
0.565CysLeu: 0.565 ± 0.02
0.102CysMet: 0.102 ± 0.009
0.222CysAsn: 0.222 ± 0.013
0.516CysPro: 0.516 ± 0.025
0.19CysGln: 0.19 ± 0.014
0.528CysArg: 0.528 ± 0.025
0.539CysSer: 0.539 ± 0.025
0.431CysThr: 0.431 ± 0.02
0.491CysVal: 0.491 ± 0.021
0.105CysTrp: 0.105 ± 0.009
0.227CysTyr: 0.227 ± 0.017
0.0CysXaa: 0.0 ± 0.0
Asp
8.808AspAla: 8.808 ± 0.119
0.73AspCys: 0.73 ± 0.028
8.408AspAsp: 8.408 ± 0.12
8.456AspGlu: 8.456 ± 0.102
2.057AspPhe: 2.057 ± 0.047
8.43AspGly: 8.43 ± 0.123
2.026AspHis: 2.026 ± 0.052
3.296AspIle: 3.296 ± 0.055
0.969AspLys: 0.969 ± 0.036
6.877AspLeu: 6.877 ± 0.092
1.179AspMet: 1.179 ± 0.031
1.444AspAsn: 1.444 ± 0.047
4.468AspPro: 4.468 ± 0.072
1.871AspGln: 1.871 ± 0.036
6.977AspArg: 6.977 ± 0.091
4.317AspSer: 4.317 ± 0.084
4.124AspThr: 4.124 ± 0.063
7.642AspVal: 7.642 ± 0.089
1.027AspTrp: 1.027 ± 0.035
1.894AspTyr: 1.894 ± 0.042
0.0AspXaa: 0.0 ± 0.0
Glu
8.014GluAla: 8.014 ± 0.096
0.547GluCys: 0.547 ± 0.024
5.696GluAsp: 5.696 ± 0.096
6.441GluGlu: 6.441 ± 0.101
3.044GluPhe: 3.044 ± 0.05
5.148GluGly: 5.148 ± 0.092
1.809GluHis: 1.809 ± 0.045
4.46GluIle: 4.46 ± 0.069
1.998GluLys: 1.998 ± 0.052
7.318GluLeu: 7.318 ± 0.096
1.771GluMet: 1.771 ± 0.039
2.778GluAsn: 2.778 ± 0.057
4.259GluPro: 4.259 ± 0.081
2.838GluGln: 2.838 ± 0.052
7.491GluArg: 7.491 ± 0.102
5.84GluSer: 5.84 ± 0.08
7.309GluThr: 7.309 ± 0.098
5.065GluVal: 5.065 ± 0.077
1.191GluTrp: 1.191 ± 0.034
2.992GluTyr: 2.992 ± 0.06
0.0GluXaa: 0.0 ± 0.0
Phe
3.533PheAla: 3.533 ± 0.066
0.308PheCys: 0.308 ± 0.018
3.426PheAsp: 3.426 ± 0.062
3.122PheGlu: 3.122 ± 0.055
1.065PhePhe: 1.065 ± 0.034
3.212PheGly: 3.212 ± 0.056
0.693PheHis: 0.693 ± 0.025
1.19PheIle: 1.19 ± 0.038
0.47PheLys: 0.47 ± 0.022
2.922PheLeu: 2.922 ± 0.063
0.514PheMet: 0.514 ± 0.022
0.716PheAsn: 0.716 ± 0.029
1.329PhePro: 1.329 ± 0.038
0.868PheGln: 0.868 ± 0.03
1.774PheArg: 1.774 ± 0.043
1.732PheSer: 1.732 ± 0.044
1.952PheThr: 1.952 ± 0.042
3.207PheVal: 3.207 ± 0.053
0.438PheTrp: 0.438 ± 0.023
0.882PheTyr: 0.882 ± 0.032
0.0PheXaa: 0.0 ± 0.0
Gly
7.271GlyAla: 7.271 ± 0.094
0.792GlyCys: 0.792 ± 0.031
6.801GlyAsp: 6.801 ± 0.104
6.554GlyGlu: 6.554 ± 0.083
3.135GlyPhe: 3.135 ± 0.056
7.226GlyGly: 7.226 ± 0.118
1.631GlyHis: 1.631 ± 0.039
4.797GlyIle: 4.797 ± 0.071
1.857GlyLys: 1.857 ± 0.046
7.122GlyLeu: 7.122 ± 0.1
1.757GlyMet: 1.757 ± 0.045
2.311GlyAsn: 2.311 ± 0.064
3.221GlyPro: 3.221 ± 0.063
2.07GlyGln: 2.07 ± 0.044
4.793GlyArg: 4.793 ± 0.056
5.458GlySer: 5.458 ± 0.091
6.16GlyThr: 6.16 ± 0.084
6.67GlyVal: 6.67 ± 0.092
1.183GlyTrp: 1.183 ± 0.036
2.697GlyTyr: 2.697 ± 0.049
0.0GlyXaa: 0.0 ± 0.0
His
1.894HisAla: 1.894 ± 0.043
0.235HisCys: 0.235 ± 0.015
1.862HisAsp: 1.862 ± 0.047
1.66HisGlu: 1.66 ± 0.04
0.569HisPhe: 0.569 ± 0.023
1.989HisGly: 1.989 ± 0.046
0.57HisHis: 0.57 ± 0.023
0.737HisIle: 0.737 ± 0.027
0.282HisLys: 0.282 ± 0.017
1.732HisLeu: 1.732 ± 0.035
0.3HisMet: 0.3 ± 0.018
0.463HisAsn: 0.463 ± 0.02
1.235HisPro: 1.235 ± 0.033
0.467HisGln: 0.467 ± 0.018
1.422HisArg: 1.422 ± 0.039
0.915HisSer: 0.915 ± 0.029
1.079HisThr: 1.079 ± 0.032
1.814HisVal: 1.814 ± 0.038
0.245HisTrp: 0.245 ± 0.015
0.596HisTyr: 0.596 ± 0.024
0.0HisXaa: 0.0 ± 0.0
Ile
5.522IleAla: 5.522 ± 0.08
0.324IleCys: 0.324 ± 0.014
4.844IleAsp: 4.844 ± 0.067
4.785IleGlu: 4.785 ± 0.072
1.145IlePhe: 1.145 ± 0.035
4.537IleGly: 4.537 ± 0.072
0.875IleHis: 0.875 ± 0.025
1.556IleIle: 1.556 ± 0.045
0.764IleLys: 0.764 ± 0.028
3.468IleLeu: 3.468 ± 0.063
0.565IleMet: 0.565 ± 0.022
1.064IleAsn: 1.064 ± 0.03
2.218IlePro: 2.218 ± 0.045
1.191IleGln: 1.191 ± 0.036
2.843IleArg: 2.843 ± 0.055
2.683IleSer: 2.683 ± 0.05
2.826IleThr: 2.826 ± 0.046
4.537IleVal: 4.537 ± 0.077
0.447IleTrp: 0.447 ± 0.02
1.041IleTyr: 1.041 ± 0.035
0.0IleXaa: 0.0 ± 0.0
Lys
1.671LysAla: 1.671 ± 0.04
0.117LysCys: 0.117 ± 0.011
1.131LysAsp: 1.131 ± 0.038
1.334LysGlu: 1.334 ± 0.043
0.558LysPhe: 0.558 ± 0.027
1.297LysGly: 1.297 ± 0.037
0.524LysHis: 0.524 ± 0.023
0.893LysIle: 0.893 ± 0.028
0.61LysLys: 0.61 ± 0.031
1.68LysLeu: 1.68 ± 0.037
0.418LysMet: 0.418 ± 0.021
0.638LysAsn: 0.638 ± 0.025
1.037LysPro: 1.037 ± 0.036
0.736LysGln: 0.736 ± 0.027
1.769LysArg: 1.769 ± 0.039
1.27LysSer: 1.27 ± 0.034
1.46LysThr: 1.46 ± 0.037
1.082LysVal: 1.082 ± 0.03
0.232LysTrp: 0.232 ± 0.015
0.591LysTyr: 0.591 ± 0.021
0.0LysXaa: 0.0 ± 0.0
Leu
9.82LeuAla: 9.82 ± 0.114
0.637LeuCys: 0.637 ± 0.025
6.082LeuAsp: 6.082 ± 0.086
10.284LeuGlu: 10.284 ± 0.108
3.156LeuPhe: 3.156 ± 0.066
6.906LeuGly: 6.906 ± 0.095
1.467LeuHis: 1.467 ± 0.035
3.447LeuIle: 3.447 ± 0.063
1.472LeuLys: 1.472 ± 0.039
8.147LeuLeu: 8.147 ± 0.111
1.233LeuMet: 1.233 ± 0.033
1.761LeuAsn: 1.761 ± 0.039
3.93LeuPro: 3.93 ± 0.066
2.082LeuGln: 2.082 ± 0.046
4.965LeuArg: 4.965 ± 0.07
5.577LeuSer: 5.577 ± 0.077
5.283LeuThr: 5.283 ± 0.069
7.649LeuVal: 7.649 ± 0.104
0.865LeuTrp: 0.865 ± 0.029
2.22LeuTyr: 2.22 ± 0.04
0.0LeuXaa: 0.0 ± 0.0
Met
1.78MetAla: 1.78 ± 0.042
0.117MetCys: 0.117 ± 0.01
1.198MetAsp: 1.198 ± 0.031
1.07MetGlu: 1.07 ± 0.03
0.517MetPhe: 0.517 ± 0.023
1.373MetGly: 1.373 ± 0.033
0.354MetHis: 0.354 ± 0.019
0.838MetIle: 0.838 ± 0.03
0.473MetLys: 0.473 ± 0.019
1.508MetLeu: 1.508 ± 0.041
0.323MetMet: 0.323 ± 0.019
0.703MetAsn: 0.703 ± 0.026
0.806MetPro: 0.806 ± 0.026
0.517MetGln: 0.517 ± 0.021
1.013MetArg: 1.013 ± 0.029
1.483MetSer: 1.483 ± 0.035
1.646MetThr: 1.646 ± 0.04
1.229MetVal: 1.229 ± 0.038
0.183MetTrp: 0.183 ± 0.014
0.408MetTyr: 0.408 ± 0.018
0.0MetXaa: 0.0 ± 0.0
Asn
2.767AsnAla: 2.767 ± 0.048
0.278AsnCys: 0.278 ± 0.02
2.0AsnAsp: 2.0 ± 0.044
2.262AsnGlu: 2.262 ± 0.054
0.671AsnPhe: 0.671 ± 0.03
2.527AsnGly: 2.527 ± 0.064
0.561AsnHis: 0.561 ± 0.023
0.93AsnIle: 0.93 ± 0.033
0.472AsnLys: 0.472 ± 0.023
2.028AsnLeu: 2.028 ± 0.045
0.425AsnMet: 0.425 ± 0.018
0.626AsnAsn: 0.626 ± 0.03
1.663AsnPro: 1.663 ± 0.044
0.692AsnGln: 0.692 ± 0.024
1.948AsnArg: 1.948 ± 0.048
1.185AsnSer: 1.185 ± 0.035
1.387AsnThr: 1.387 ± 0.038
2.492AsnVal: 2.492 ± 0.051
0.375AsnTrp: 0.375 ± 0.02
0.721AsnTyr: 0.721 ± 0.028
0.0AsnXaa: 0.0 ± 0.0
Pro
4.346ProAla: 4.346 ± 0.063
0.252ProCys: 0.252 ± 0.016
4.846ProAsp: 4.846 ± 0.076
4.017ProGlu: 4.017 ± 0.073
1.585ProPhe: 1.585 ± 0.038
3.567ProGly: 3.567 ± 0.072
0.886ProHis: 0.886 ± 0.027
2.307ProIle: 2.307 ± 0.046
0.881ProLys: 0.881 ± 0.027
3.684ProLeu: 3.684 ± 0.054
0.876ProMet: 0.876 ± 0.026
1.318ProAsn: 1.318 ± 0.035
2.142ProPro: 2.142 ± 0.06
1.039ProGln: 1.039 ± 0.029
2.277ProArg: 2.277 ± 0.043
2.831ProSer: 2.831 ± 0.06
3.231ProThr: 3.231 ± 0.057
3.834ProVal: 3.834 ± 0.064
0.525ProTrp: 0.525 ± 0.024
1.116ProTyr: 1.116 ± 0.032
0.0ProXaa: 0.0 ± 0.0
Gln
2.328GlnAla: 2.328 ± 0.048
0.175GlnCys: 0.175 ± 0.012
1.422GlnAsp: 1.422 ± 0.037
1.762GlnGlu: 1.762 ± 0.04
1.056GlnPhe: 1.056 ± 0.033
1.663GlnGly: 1.663 ± 0.039
0.533GlnHis: 0.533 ± 0.022
1.275GlnIle: 1.275 ± 0.038
0.657GlnLys: 0.657 ± 0.023
2.495GlnLeu: 2.495 ± 0.051
0.53GlnMet: 0.53 ± 0.02
0.817GlnAsn: 0.817 ± 0.033
1.216GlnPro: 1.216 ± 0.034
1.1GlnGln: 1.1 ± 0.034
1.982GlnArg: 1.982 ± 0.05
1.774GlnSer: 1.774 ± 0.04
1.781GlnThr: 1.781 ± 0.039
1.79GlnVal: 1.79 ± 0.04
0.358GlnTrp: 0.358 ± 0.017
0.881GlnTyr: 0.881 ± 0.027
0.0GlnXaa: 0.0 ± 0.0
Arg
5.735ArgAla: 5.735 ± 0.083
0.474ArgCys: 0.474 ± 0.021
5.172ArgAsp: 5.172 ± 0.078
6.127ArgGlu: 6.127 ± 0.084
2.337ArgPhe: 2.337 ± 0.041
4.237ArgGly: 4.237 ± 0.058
1.216ArgHis: 1.216 ± 0.036
3.52ArgIle: 3.52 ± 0.048
1.579ArgLys: 1.579 ± 0.038
6.036ArgLeu: 6.036 ± 0.079
1.386ArgMet: 1.386 ± 0.033
1.97ArgAsn: 1.97 ± 0.051
2.502ArgPro: 2.502 ± 0.051
1.85ArgGln: 1.85 ± 0.044
4.918ArgArg: 4.918 ± 0.07
4.035ArgSer: 4.035 ± 0.068
4.407ArgThr: 4.407 ± 0.066
4.664ArgVal: 4.664 ± 0.064
0.849ArgTrp: 0.849 ± 0.027
2.092ArgTyr: 2.092 ± 0.046
0.0ArgXaa: 0.0 ± 0.0
Ser
5.357SerAla: 5.357 ± 0.071
0.347SerCys: 0.347 ± 0.017
5.112SerAsp: 5.112 ± 0.085
4.671SerGlu: 4.671 ± 0.073
2.023SerPhe: 2.023 ± 0.043
5.508SerGly: 5.508 ± 0.08
1.179SerHis: 1.179 ± 0.031
3.063SerIle: 3.063 ± 0.052
1.328SerLys: 1.328 ± 0.038
5.148SerLeu: 5.148 ± 0.066
1.2SerMet: 1.2 ± 0.033
1.746SerAsn: 1.746 ± 0.042
2.721SerPro: 2.721 ± 0.056
1.519SerGln: 1.519 ± 0.036
3.443SerArg: 3.443 ± 0.053
3.867SerSer: 3.867 ± 0.075
3.884SerThr: 3.884 ± 0.059
5.19SerVal: 5.19 ± 0.063
0.64SerTrp: 0.64 ± 0.028
1.528SerTyr: 1.528 ± 0.039
0.0SerXaa: 0.0 ± 0.0
Thr
7.098ThrAla: 7.098 ± 0.096
0.437ThrCys: 0.437 ± 0.022
6.102ThrAsp: 6.102 ± 0.09
5.082ThrGlu: 5.082 ± 0.064
2.212ThrPhe: 2.212 ± 0.048
6.072ThrGly: 6.072 ± 0.087
1.238ThrHis: 1.238 ± 0.034
3.766ThrIle: 3.766 ± 0.058
1.201ThrLys: 1.201 ± 0.034
5.718ThrLeu: 5.718 ± 0.074
1.103ThrMet: 1.103 ± 0.032
1.771ThrAsn: 1.771 ± 0.041
3.006ThrPro: 3.006 ± 0.054
1.419ThrGln: 1.419 ± 0.039
3.371ThrArg: 3.371 ± 0.053
3.364ThrSer: 3.364 ± 0.055
4.558ThrThr: 4.558 ± 0.076
7.038ThrVal: 7.038 ± 0.083
0.702ThrTrp: 0.702 ± 0.023
1.742ThrTyr: 1.742 ± 0.042
0.0ThrXaa: 0.0 ± 0.0
Val
8.994ValAla: 8.994 ± 0.124
0.713ValCys: 0.713 ± 0.024
7.473ValAsp: 7.473 ± 0.081
6.761ValGlu: 6.761 ± 0.088
2.88ValPhe: 2.88 ± 0.056
7.156ValGly: 7.156 ± 0.101
1.622ValHis: 1.622 ± 0.036
3.779ValIle: 3.779 ± 0.062
1.332ValLys: 1.332 ± 0.032
7.633ValLeu: 7.633 ± 0.103
1.29ValMet: 1.29 ± 0.035
1.88ValAsn: 1.88 ± 0.037
4.119ValPro: 4.119 ± 0.062
1.891ValGln: 1.891 ± 0.041
5.149ValArg: 5.149 ± 0.076
5.25ValSer: 5.25 ± 0.073
6.226ValThr: 6.226 ± 0.072
7.965ValVal: 7.965 ± 0.113
0.833ValTrp: 0.833 ± 0.026
2.09ValTyr: 2.09 ± 0.045
0.0ValXaa: 0.0 ± 0.0
Trp
0.885TrpAla: 0.885 ± 0.026
0.117TrpCys: 0.117 ± 0.011
0.851TrpAsp: 0.851 ± 0.029
0.827TrpGlu: 0.827 ± 0.029
0.458TrpPhe: 0.458 ± 0.024
0.861TrpGly: 0.861 ± 0.027
0.278TrpHis: 0.278 ± 0.017
0.623TrpIle: 0.623 ± 0.024
0.321TrpLys: 0.321 ± 0.017
1.229TrpLeu: 1.229 ± 0.037
0.224TrpMet: 0.224 ± 0.013
0.461TrpAsn: 0.461 ± 0.021
0.487TrpPro: 0.487 ± 0.022
0.433TrpGln: 0.433 ± 0.021
0.819TrpArg: 0.819 ± 0.027
0.681TrpSer: 0.681 ± 0.025
0.819TrpThr: 0.819 ± 0.031
0.819TrpVal: 0.819 ± 0.028
0.232TrpTrp: 0.232 ± 0.016
0.374TrpTyr: 0.374 ± 0.02
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.645TyrAla: 2.645 ± 0.046
0.273TyrCys: 0.273 ± 0.016
2.712TyrAsp: 2.712 ± 0.049
2.571TyrGlu: 2.571 ± 0.046
0.936TyrPhe: 0.936 ± 0.031
2.341TyrGly: 2.341 ± 0.047
0.672TyrHis: 0.672 ± 0.025
0.806TyrIle: 0.806 ± 0.026
0.452TyrLys: 0.452 ± 0.02
2.421TyrLeu: 2.421 ± 0.043
0.373TyrMet: 0.373 ± 0.019
0.686TyrAsn: 0.686 ± 0.024
1.277TyrPro: 1.277 ± 0.039
0.746TyrGln: 0.746 ± 0.027
2.003TyrArg: 2.003 ± 0.044
1.364TyrSer: 1.364 ± 0.036
1.537TyrThr: 1.537 ± 0.034
2.43TyrVal: 2.43 ± 0.051
0.377TyrTrp: 0.377 ± 0.022
0.886TyrTyr: 0.886 ± 0.03
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 3981 proteins (1144613 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski