Amino acid dipepetide frequency for Streptococcus suis (strain 05ZYH33)

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	5.814AlaAla: 5.814 ± 0.144	0.543AlaCys: 0.543 ± 0.031	4.494AlaAsp: 4.494 ± 0.086	5.358AlaGlu: 5.358 ± 0.113	3.312AlaPhe: 3.312 ± 0.071	5.906AlaGly: 5.906 ± 0.119	1.302AlaHis: 1.302 ± 0.045	5.913AlaIle: 5.913 ± 0.108	4.799AlaLys: 4.799 ± 0.085	7.463AlaLeu: 7.463 ± 0.127	1.975AlaMet: 1.975 ± 0.059	3.149AlaAsn: 3.149 ± 0.087	2.218AlaPro: 2.218 ± 0.077	3.148AlaGln: 3.148 ± 0.078	2.911AlaArg: 2.911 ± 0.069	4.616AlaSer: 4.616 ± 0.092	4.497AlaThr: 4.497 ± 0.094	5.492AlaVal: 5.492 ± 0.095	0.65AlaTrp: 0.65 ± 0.03	2.793AlaTyr: 2.793 ± 0.058	0.0AlaXaa: 0.0 ± 0.0
Cys	0.315CysAla: 0.315 ± 0.026	0.062CysCys: 0.062 ± 0.009	0.289CysAsp: 0.289 ± 0.024	0.271CysGlu: 0.271 ± 0.02	0.31CysPhe: 0.31 ± 0.022	0.491CysGly: 0.491 ± 0.03	0.217CysHis: 0.217 ± 0.019	0.383CysIle: 0.383 ± 0.023	0.297CysLys: 0.297 ± 0.025	0.729CysLeu: 0.729 ± 0.037	0.151CysMet: 0.151 ± 0.016	0.209CysAsn: 0.209 ± 0.017	0.273CysPro: 0.273 ± 0.021	0.42CysGln: 0.42 ± 0.029	0.274CysArg: 0.274 ± 0.021	0.424CysSer: 0.424 ± 0.037	0.261CysThr: 0.261 ± 0.02	0.312CysVal: 0.312 ± 0.025	0.053CysTrp: 0.053 ± 0.01	0.227CysTyr: 0.227 ± 0.02	0.0CysXaa: 0.0 ± 0.0
Asp	3.667AspAla: 3.667 ± 0.075	0.373AspCys: 0.373 ± 0.026	2.606AspAsp: 2.606 ± 0.068	4.077AspGlu: 4.077 ± 0.085	3.3AspPhe: 3.3 ± 0.084	3.873AspGly: 3.873 ± 0.1	0.916AspHis: 0.916 ± 0.042	4.246AspIle: 4.246 ± 0.092	3.997AspLys: 3.997 ± 0.084	5.817AspLeu: 5.817 ± 0.105	1.504AspMet: 1.504 ± 0.054	2.355AspAsn: 2.355 ± 0.066	1.547AspPro: 1.547 ± 0.057	2.089AspGln: 2.089 ± 0.059	2.139AspArg: 2.139 ± 0.063	3.148AspSer: 3.148 ± 0.075	2.896AspThr: 2.896 ± 0.071	3.627AspVal: 3.627 ± 0.078	0.719AspTrp: 0.719 ± 0.036	2.818AspTyr: 2.818 ± 0.067	0.0AspXaa: 0.0 ± 0.0
Glu	5.566GluAla: 5.566 ± 0.127	0.3GluCys: 0.3 ± 0.024	3.734GluAsp: 3.734 ± 0.08	6.499GluGlu: 6.499 ± 0.127	2.798GluPhe: 2.798 ± 0.067	3.809GluGly: 3.809 ± 0.076	1.276GluHis: 1.276 ± 0.046	5.217GluIle: 5.217 ± 0.09	5.867GluLys: 5.867 ± 0.106	7.169GluLeu: 7.169 ± 0.119	1.91GluMet: 1.91 ± 0.06	4.018GluAsn: 4.018 ± 0.076	1.696GluPro: 1.696 ± 0.059	3.274GluGln: 3.274 ± 0.085	3.33GluArg: 3.33 ± 0.082	3.374GluSer: 3.374 ± 0.08	3.827GluThr: 3.827 ± 0.093	5.092GluVal: 5.092 ± 0.113	0.64GluTrp: 0.64 ± 0.032	2.102GluTyr: 2.102 ± 0.059	0.0GluXaa: 0.0 ± 0.0
Phe	3.376PheAla: 3.376 ± 0.083	0.294PheCys: 0.294 ± 0.023	2.924PheAsp: 2.924 ± 0.074	3.164PheGlu: 3.164 ± 0.074	2.204PhePhe: 2.204 ± 0.081	3.34PheGly: 3.34 ± 0.073	0.88PheHis: 0.88 ± 0.04	3.072PheIle: 3.072 ± 0.083	2.351PheLys: 2.351 ± 0.071	4.637PheLeu: 4.637 ± 0.11	1.151PheMet: 1.151 ± 0.054	1.823PheAsn: 1.823 ± 0.051	1.575PhePro: 1.575 ± 0.057	1.621PheGln: 1.621 ± 0.055	1.63PheArg: 1.63 ± 0.055	3.185PheSer: 3.185 ± 0.08	2.532PheThr: 2.532 ± 0.063	3.174PheVal: 3.174 ± 0.082	0.498PheTrp: 0.498 ± 0.031	1.887PheTyr: 1.887 ± 0.059	0.0PheXaa: 0.0 ± 0.0
Gly	4.643GlyAla: 4.643 ± 0.101	0.404GlyCys: 0.404 ± 0.027	3.376GlyAsp: 3.376 ± 0.087	3.791GlyGlu: 3.791 ± 0.083	3.286GlyPhe: 3.286 ± 0.074	4.267GlyGly: 4.267 ± 0.106	1.379GlyHis: 1.379 ± 0.049	5.327GlyIle: 5.327 ± 0.098	4.583GlyLys: 4.583 ± 0.103	7.056GlyLeu: 7.056 ± 0.109	1.901GlyMet: 1.901 ± 0.062	2.786GlyAsn: 2.786 ± 0.071	1.433GlyPro: 1.433 ± 0.049	3.359GlyGln: 3.359 ± 0.08	2.906GlyArg: 2.906 ± 0.081	3.668GlySer: 3.668 ± 0.084	3.716GlyThr: 3.716 ± 0.097	4.737GlyVal: 4.737 ± 0.092	0.637GlyTrp: 0.637 ± 0.03	2.75GlyTyr: 2.75 ± 0.073	0.0GlyXaa: 0.0 ± 0.0
His	1.227HisAla: 1.227 ± 0.051	0.138HisCys: 0.138 ± 0.015	0.887HisAsp: 0.887 ± 0.035	1.095HisGlu: 1.095 ± 0.044	1.117HisPhe: 1.117 ± 0.049	1.259HisGly: 1.259 ± 0.049	0.54HisHis: 0.54 ± 0.034	1.314HisIle: 1.314 ± 0.053	0.892HisLys: 0.892 ± 0.038	2.159HisLeu: 2.159 ± 0.067	0.415HisMet: 0.415 ± 0.025	0.69HisAsn: 0.69 ± 0.033	0.869HisPro: 0.869 ± 0.049	0.928HisGln: 0.928 ± 0.043	0.949HisArg: 0.949 ± 0.044	1.12HisSer: 1.12 ± 0.045	0.988HisThr: 0.988 ± 0.037	1.095HisVal: 1.095 ± 0.046	0.146HisTrp: 0.146 ± 0.015	0.923HisTyr: 0.923 ± 0.04	0.0HisXaa: 0.0 ± 0.0
Ile	6.254IleAla: 6.254 ± 0.106	0.573IleCys: 0.573 ± 0.032	4.315IleAsp: 4.315 ± 0.086	5.128IleGlu: 5.128 ± 0.083	3.351IlePhe: 3.351 ± 0.092	5.006IleGly: 5.006 ± 0.099	1.374IleHis: 1.374 ± 0.046	4.811IleIle: 4.811 ± 0.115	3.978IleLys: 3.978 ± 0.088	7.325IleLeu: 7.325 ± 0.138	1.801IleMet: 1.801 ± 0.058	2.816IleAsn: 2.816 ± 0.067	2.824IlePro: 2.824 ± 0.072	2.819IleGln: 2.819 ± 0.072	3.016IleArg: 3.016 ± 0.074	4.916IleSer: 4.916 ± 0.098	3.642IleThr: 3.642 ± 0.082	4.74IleVal: 4.74 ± 0.093	0.631IleTrp: 0.631 ± 0.034	2.565IleTyr: 2.565 ± 0.059	0.0IleXaa: 0.0 ± 0.0
Lys	4.698LysAla: 4.698 ± 0.106	0.246LysCys: 0.246 ± 0.021	3.535LysAsp: 3.535 ± 0.089	5.704LysGlu: 5.704 ± 0.103	1.872LysPhe: 1.872 ± 0.057	3.768LysGly: 3.768 ± 0.079	1.146LysHis: 1.146 ± 0.045	4.519LysIle: 4.519 ± 0.093	4.852LysLys: 4.852 ± 0.106	5.678LysLeu: 5.678 ± 0.099	1.901LysMet: 1.901 ± 0.056	3.309LysAsn: 3.309 ± 0.079	2.087LysPro: 2.087 ± 0.059	2.86LysGln: 2.86 ± 0.068	3.031LysArg: 3.031 ± 0.074	3.471LysSer: 3.471 ± 0.076	3.868LysThr: 3.868 ± 0.088	4.448LysVal: 4.448 ± 0.094	0.585LysTrp: 0.585 ± 0.036	2.08LysTyr: 2.08 ± 0.062	0.0LysXaa: 0.0 ± 0.0
Leu	9.009LeuAla: 9.009 ± 0.13	0.575LeuCys: 0.575 ± 0.038	6.1LeuAsp: 6.1 ± 0.107	7.305LeuGlu: 7.305 ± 0.132	4.379LeuPhe: 4.379 ± 0.12	6.553LeuGly: 6.553 ± 0.127	1.686LeuHis: 1.686 ± 0.054	6.591LeuIle: 6.591 ± 0.147	5.867LeuLys: 5.867 ± 0.093	10.328LeuLeu: 10.328 ± 0.197	2.397LeuMet: 2.397 ± 0.074	3.964LeuAsn: 3.964 ± 0.09	4.323LeuPro: 4.323 ± 0.089	3.663LeuGln: 3.663 ± 0.078	3.872LeuArg: 3.872 ± 0.073	7.059LeuSer: 7.059 ± 0.121	6.414LeuThr: 6.414 ± 0.116	7.466LeuVal: 7.466 ± 0.12	0.706LeuTrp: 0.706 ± 0.034	3.356LeuTyr: 3.356 ± 0.077	0.0LeuXaa: 0.0 ± 0.0
Met	2.057MetAla: 2.057 ± 0.069	0.161MetCys: 0.161 ± 0.017	1.448MetAsp: 1.448 ± 0.047	1.77MetGlu: 1.77 ± 0.061	0.801MetPhe: 0.801 ± 0.036	1.65MetGly: 1.65 ± 0.064	0.373MetHis: 0.373 ± 0.025	1.869MetIle: 1.869 ± 0.06	2.075MetLys: 2.075 ± 0.053	2.254MetLeu: 2.254 ± 0.066	0.788MetMet: 0.788 ± 0.043	1.296MetAsn: 1.296 ± 0.05	0.857MetPro: 0.857 ± 0.037	0.862MetGln: 0.862 ± 0.037	1.095MetArg: 1.095 ± 0.042	1.543MetSer: 1.543 ± 0.053	1.91MetThr: 1.91 ± 0.059	1.829MetVal: 1.829 ± 0.051	0.156MetTrp: 0.156 ± 0.017	0.616MetTyr: 0.616 ± 0.03	0.0MetXaa: 0.0 ± 0.0
Asn	2.939AsnAla: 2.939 ± 0.072	0.251AsnCys: 0.251 ± 0.024	2.222AsnAsp: 2.222 ± 0.062	2.415AsnGlu: 2.415 ± 0.07	2.018AsnPhe: 2.018 ± 0.063	3.245AsnGly: 3.245 ± 0.081	1.01AsnHis: 1.01 ± 0.04	3.248AsnIle: 3.248 ± 0.074	2.588AsnLys: 2.588 ± 0.078	4.519AsnLeu: 4.519 ± 0.086	1.138AsnMet: 1.138 ± 0.039	1.852AsnAsn: 1.852 ± 0.062	2.159AsnPro: 2.159 ± 0.062	2.272AsnGln: 2.272 ± 0.07	2.126AsnArg: 2.126 ± 0.065	2.478AsnSer: 2.478 ± 0.075	2.115AsnThr: 2.115 ± 0.066	2.647AsnVal: 2.647 ± 0.059	0.54AsnTrp: 0.54 ± 0.036	1.808AsnTyr: 1.808 ± 0.058	0.0AsnXaa: 0.0 ± 0.0
Pro	2.662ProAla: 2.662 ± 0.067	0.194ProCys: 0.194 ± 0.019	2.008ProAsp: 2.008 ± 0.059	2.829ProGlu: 2.829 ± 0.082	1.634ProPhe: 1.634 ± 0.038	1.801ProGly: 1.801 ± 0.066	0.695ProHis: 0.695 ± 0.033	2.524ProIle: 2.524 ± 0.055	2.059ProLys: 2.059 ± 0.095	3.046ProLeu: 3.046 ± 0.07	0.79ProMet: 0.79 ± 0.037	1.593ProAsn: 1.593 ± 0.054	0.634ProPro: 0.634 ± 0.039	1.318ProGln: 1.318 ± 0.049	1.102ProArg: 1.102 ± 0.048	2.228ProSer: 2.228 ± 0.068	2.327ProThr: 2.327 ± 0.069	2.658ProVal: 2.658 ± 0.072	0.281ProTrp: 0.281 ± 0.024	1.337ProTyr: 1.337 ± 0.048	0.0ProXaa: 0.0 ± 0.0
Gln	4.034GlnAla: 4.034 ± 0.095	0.136GlnCys: 0.136 ± 0.015	2.006GlnAsp: 2.006 ± 0.056	3.553GlnGlu: 3.553 ± 0.068	1.737GlnPhe: 1.737 ± 0.051	2.379GlnGly: 2.379 ± 0.068	0.68GlnHis: 0.68 ± 0.037	3.066GlnIle: 3.066 ± 0.074	2.635GlnLys: 2.635 ± 0.059	4.612GlnLeu: 4.612 ± 0.101	1.056GlnMet: 1.056 ± 0.047	1.588GlnAsn: 1.588 ± 0.054	1.317GlnPro: 1.317 ± 0.059	1.649GlnGln: 1.649 ± 0.059	1.603GlnArg: 1.603 ± 0.054	2.438GlnSer: 2.438 ± 0.067	2.629GlnThr: 2.629 ± 0.079	3.586GlnVal: 3.586 ± 0.078	0.337GlnTrp: 0.337 ± 0.027	1.397GlnTyr: 1.397 ± 0.051	0.0GlnXaa: 0.0 ± 0.0
Arg	2.652ArgAla: 2.652 ± 0.078	0.204ArgCys: 0.204 ± 0.019	2.184ArgAsp: 2.184 ± 0.063	3.102ArgGlu: 3.102 ± 0.085	2.054ArgPhe: 2.054 ± 0.059	2.384ArgGly: 2.384 ± 0.067	0.842ArgHis: 0.842 ± 0.043	3.174ArgIle: 3.174 ± 0.074	3.011ArgLys: 3.011 ± 0.08	4.31ArgLeu: 4.31 ± 0.096	1.177ArgMet: 1.177 ± 0.044	1.873ArgAsn: 1.873 ± 0.06	1.299ArgPro: 1.299 ± 0.046	2.189ArgGln: 2.189 ± 0.06	2.066ArgArg: 2.066 ± 0.069	2.164ArgSer: 2.164 ± 0.058	2.215ArgThr: 2.215 ± 0.069	2.737ArgVal: 2.737 ± 0.068	0.332ArgTrp: 0.332 ± 0.027	1.688ArgTyr: 1.688 ± 0.058	0.0ArgXaa: 0.0 ± 0.0
Ser	3.8SerAla: 3.8 ± 0.089	0.394SerCys: 0.394 ± 0.025	3.243SerAsp: 3.243 ± 0.074	3.737SerGlu: 3.737 ± 0.088	2.992SerPhe: 2.992 ± 0.081	4.331SerGly: 4.331 ± 0.088	1.238SerHis: 1.238 ± 0.047	4.282SerIle: 4.282 ± 0.093	3.648SerLys: 3.648 ± 0.072	6.796SerLeu: 6.796 ± 0.13	1.399SerMet: 1.399 ± 0.046	2.532SerAsn: 2.532 ± 0.067	2.105SerPro: 2.105 ± 0.068	3.11SerGln: 3.11 ± 0.076	2.534SerArg: 2.534 ± 0.061	4.302SerSer: 4.302 ± 0.115	3.494SerThr: 3.494 ± 0.07	4.097SerVal: 4.097 ± 0.081	0.644SerTrp: 0.644 ± 0.028	2.584SerTyr: 2.584 ± 0.057	0.0SerXaa: 0.0 ± 0.0
Thr	4.376ThrAla: 4.376 ± 0.096	0.34ThrCys: 0.34 ± 0.026	3.519ThrAsp: 3.519 ± 0.087	3.716ThrGlu: 3.716 ± 0.09	2.599ThrPhe: 2.599 ± 0.071	4.404ThrGly: 4.404 ± 0.103	0.957ThrHis: 0.957 ± 0.043	4.663ThrIle: 4.663 ± 0.102	3.277ThrLys: 3.277 ± 0.085	5.443ThrLeu: 5.443 ± 0.101	1.266ThrMet: 1.266 ± 0.051	2.478ThrAsn: 2.478 ± 0.076	2.404ThrPro: 2.404 ± 0.084	1.816ThrGln: 1.816 ± 0.056	1.941ThrArg: 1.941 ± 0.064	3.875ThrSer: 3.875 ± 0.093	3.356ThrThr: 3.356 ± 0.094	4.62ThrVal: 4.62 ± 0.107	0.532ThrTrp: 0.532 ± 0.031	2.31ThrTyr: 2.31 ± 0.062	0.0ThrXaa: 0.0 ± 0.0
Val	6.129ValAla: 6.129 ± 0.108	0.473ValCys: 0.473 ± 0.029	4.064ValAsp: 4.064 ± 0.089	5.212ValGlu: 5.212 ± 0.108	3.156ValPhe: 3.156 ± 0.081	4.589ValGly: 4.589 ± 0.092	1.223ValHis: 1.223 ± 0.049	4.619ValIle: 4.619 ± 0.088	4.098ValLys: 4.098 ± 0.092	6.909ValLeu: 6.909 ± 0.097	1.635ValMet: 1.635 ± 0.058	3.115ValAsn: 3.115 ± 0.075	2.484ValPro: 2.484 ± 0.073	2.353ValGln: 2.353 ± 0.063	2.885ValArg: 2.885 ± 0.079	4.359ValSer: 4.359 ± 0.096	4.673ValThr: 4.673 ± 0.113	5.097ValVal: 5.097 ± 0.112	0.566ValTrp: 0.566 ± 0.031	2.509ValTyr: 2.509 ± 0.062	0.0ValXaa: 0.0 ± 0.0
Trp	0.525TrpAla: 0.525 ± 0.028	0.051TrpCys: 0.051 ± 0.009	0.486TrpAsp: 0.486 ± 0.029	0.608TrpGlu: 0.608 ± 0.033	0.422TrpPhe: 0.422 ± 0.029	0.563TrpGly: 0.563 ± 0.034	0.161TrpHis: 0.161 ± 0.017	0.598TrpIle: 0.598 ± 0.031	0.591TrpLys: 0.591 ± 0.031	1.113TrpLeu: 1.113 ± 0.048	0.235TrpMet: 0.235 ± 0.019	0.525TrpAsn: 0.525 ± 0.031	0.207TrpPro: 0.207 ± 0.018	0.443TrpGln: 0.443 ± 0.031	0.397TrpArg: 0.397 ± 0.024	0.627TrpSer: 0.627 ± 0.034	0.585TrpThr: 0.585 ± 0.035	0.511TrpVal: 0.511 ± 0.032	0.126TrpTrp: 0.126 ± 0.014	0.414TrpTyr: 0.414 ± 0.032	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.611TyrAla: 2.611 ± 0.073	0.255TyrCys: 0.255 ± 0.021	2.274TyrAsp: 2.274 ± 0.068	2.164TyrGlu: 2.164 ± 0.069	1.975TyrPhe: 1.975 ± 0.056	2.386TyrGly: 2.386 ± 0.061	0.854TyrHis: 0.854 ± 0.039	2.455TyrIle: 2.455 ± 0.074	2.192TyrLys: 2.192 ± 0.065	4.249TyrLeu: 4.249 ± 0.093	0.818TyrMet: 0.818 ± 0.037	1.621TyrAsn: 1.621 ± 0.057	1.407TyrPro: 1.407 ± 0.055	2.245TyrGln: 2.245 ± 0.066	1.849TyrArg: 1.849 ± 0.059	2.268TyrSer: 2.268 ± 0.065	1.947TyrThr: 1.947 ± 0.064	2.184TyrVal: 2.184 ± 0.062	0.41TyrTrp: 0.41 ± 0.033	1.768TyrTyr: 1.768 ± 0.066	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 2178 proteins (609028 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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