Amino acid dipepetide frequency for Sulfolobus virus STSV1

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
5.624AlaAla: 5.624 ± 0.661
0.187AlaCys: 0.187 ± 0.118
2.953AlaAsp: 2.953 ± 0.432
4.218AlaGlu: 4.218 ± 0.519
3.515AlaPhe: 3.515 ± 0.509
2.718AlaGly: 2.718 ± 0.346
0.937AlaHis: 0.937 ± 0.273
7.686AlaIle: 7.686 ± 0.862
5.249AlaLys: 5.249 ± 0.732
6.796AlaLeu: 6.796 ± 1.065
1.687AlaMet: 1.687 ± 0.276
4.077AlaAsn: 4.077 ± 0.845
1.968AlaPro: 1.968 ± 0.344
2.812AlaGln: 2.812 ± 0.595
2.906AlaArg: 2.906 ± 0.459
4.921AlaSer: 4.921 ± 0.612
3.046AlaThr: 3.046 ± 0.421
4.171AlaVal: 4.171 ± 0.475
0.75AlaTrp: 0.75 ± 0.339
3.843AlaTyr: 3.843 ± 0.425
0.0AlaXaa: 0.0 ± 0.0
Cys
0.234CysAla: 0.234 ± 0.111
0.047CysCys: 0.047 ± 0.047
0.375CysAsp: 0.375 ± 0.143
0.422CysGlu: 0.422 ± 0.16
0.375CysPhe: 0.375 ± 0.146
0.094CysGly: 0.094 ± 0.068
0.0CysHis: 0.0 ± 0.0
0.281CysIle: 0.281 ± 0.167
0.375CysLys: 0.375 ± 0.136
0.141CysLeu: 0.141 ± 0.081
0.047CysMet: 0.047 ± 0.046
0.469CysAsn: 0.469 ± 0.135
0.141CysPro: 0.141 ± 0.09
0.047CysGln: 0.047 ± 0.051
0.187CysArg: 0.187 ± 0.093
0.281CysSer: 0.281 ± 0.134
0.281CysThr: 0.281 ± 0.137
0.516CysVal: 0.516 ± 0.156
0.0CysTrp: 0.0 ± 0.0
0.234CysTyr: 0.234 ± 0.119
0.0CysXaa: 0.0 ± 0.0
Asp
3.562AspAla: 3.562 ± 0.644
0.094AspCys: 0.094 ± 0.064
2.906AspAsp: 2.906 ± 0.459
3.937AspGlu: 3.937 ± 0.692
2.531AspPhe: 2.531 ± 0.367
1.265AspGly: 1.265 ± 0.341
0.469AspHis: 0.469 ± 0.186
3.749AspIle: 3.749 ± 0.49
4.312AspLys: 4.312 ± 0.508
5.905AspLeu: 5.905 ± 0.709
0.703AspMet: 0.703 ± 0.19
2.343AspAsn: 2.343 ± 0.32
2.109AspPro: 2.109 ± 0.329
1.406AspGln: 1.406 ± 0.325
1.687AspArg: 1.687 ± 0.29
2.109AspSer: 2.109 ± 0.319
1.5AspThr: 1.5 ± 0.28
3.187AspVal: 3.187 ± 0.412
0.328AspTrp: 0.328 ± 0.125
2.671AspTyr: 2.671 ± 0.406
0.0AspXaa: 0.0 ± 0.0
Glu
5.249GluAla: 5.249 ± 0.776
0.281GluCys: 0.281 ± 0.129
2.812GluAsp: 2.812 ± 0.582
5.343GluGlu: 5.343 ± 0.865
2.343GluPhe: 2.343 ± 0.345
2.296GluGly: 2.296 ± 0.374
0.844GluHis: 0.844 ± 0.228
5.905GluIle: 5.905 ± 0.617
7.733GluLys: 7.733 ± 1.111
7.218GluLeu: 7.218 ± 0.706
1.172GluMet: 1.172 ± 0.305
3.89GluAsn: 3.89 ± 0.407
1.406GluPro: 1.406 ± 0.25
2.625GluGln: 2.625 ± 0.566
2.437GluArg: 2.437 ± 0.446
2.718GluSer: 2.718 ± 0.374
2.765GluThr: 2.765 ± 0.418
3.749GluVal: 3.749 ± 0.484
0.234GluTrp: 0.234 ± 0.125
2.953GluTyr: 2.953 ± 0.527
0.0GluXaa: 0.0 ± 0.0
Phe
3.374PheAla: 3.374 ± 0.59
0.422PheCys: 0.422 ± 0.187
1.922PheAsp: 1.922 ± 0.287
1.875PheGlu: 1.875 ± 0.377
2.062PhePhe: 2.062 ± 0.411
1.968PheGly: 1.968 ± 0.29
0.187PheHis: 0.187 ± 0.094
3.468PheIle: 3.468 ± 0.449
3.046PheLys: 3.046 ± 0.479
4.124PheLeu: 4.124 ± 0.69
1.078PheMet: 1.078 ± 0.289
1.968PheAsn: 1.968 ± 0.385
2.062PhePro: 2.062 ± 0.598
0.75PheGln: 0.75 ± 0.21
1.547PheArg: 1.547 ± 0.278
3.468PheSer: 3.468 ± 0.532
2.953PheThr: 2.953 ± 0.824
2.765PheVal: 2.765 ± 0.561
0.187PheTrp: 0.187 ± 0.102
2.39PheTyr: 2.39 ± 0.591
0.0PheXaa: 0.0 ± 0.0
Gly
2.015GlyAla: 2.015 ± 0.293
0.094GlyCys: 0.094 ± 0.073
2.156GlyAsp: 2.156 ± 0.323
2.062GlyGlu: 2.062 ± 0.285
2.015GlyPhe: 2.015 ± 0.274
2.531GlyGly: 2.531 ± 1.09
0.375GlyHis: 0.375 ± 0.13
3.515GlyIle: 3.515 ± 0.597
2.859GlyLys: 2.859 ± 0.366
4.171GlyLeu: 4.171 ± 0.555
0.984GlyMet: 0.984 ± 0.243
2.999GlyAsn: 2.999 ± 0.651
1.265GlyPro: 1.265 ± 0.398
1.64GlyGln: 1.64 ± 0.441
1.031GlyArg: 1.031 ± 0.24
2.765GlySer: 2.765 ± 0.593
2.484GlyThr: 2.484 ± 0.456
3.046GlyVal: 3.046 ± 0.359
0.562GlyTrp: 0.562 ± 0.17
2.437GlyTyr: 2.437 ± 0.496
0.0GlyXaa: 0.0 ± 0.0
His
0.844HisAla: 0.844 ± 0.245
0.094HisCys: 0.094 ± 0.061
0.422HisAsp: 0.422 ± 0.19
0.89HisGlu: 0.89 ± 0.209
0.656HisPhe: 0.656 ± 0.161
0.516HisGly: 0.516 ± 0.217
0.187HisHis: 0.187 ± 0.08
0.75HisIle: 0.75 ± 0.227
1.125HisLys: 1.125 ± 0.301
1.781HisLeu: 1.781 ± 0.423
0.281HisMet: 0.281 ± 0.117
0.469HisAsn: 0.469 ± 0.142
0.281HisPro: 0.281 ± 0.11
0.187HisGln: 0.187 ± 0.102
0.234HisArg: 0.234 ± 0.148
0.656HisSer: 0.656 ± 0.208
0.562HisThr: 0.562 ± 0.178
1.031HisVal: 1.031 ± 0.259
0.047HisTrp: 0.047 ± 0.046
0.703HisTyr: 0.703 ± 0.24
0.0HisXaa: 0.0 ± 0.0
Ile
5.999IleAla: 5.999 ± 0.585
0.422IleCys: 0.422 ± 0.152
4.124IleAsp: 4.124 ± 0.547
5.812IleGlu: 5.812 ± 0.849
2.765IlePhe: 2.765 ± 0.544
3.937IleGly: 3.937 ± 0.533
1.219IleHis: 1.219 ± 0.346
6.655IleIle: 6.655 ± 0.71
6.655IleLys: 6.655 ± 0.945
7.264IleLeu: 7.264 ± 0.771
1.968IleMet: 1.968 ± 0.353
6.046IleAsn: 6.046 ± 0.639
4.077IlePro: 4.077 ± 0.492
3.562IleGln: 3.562 ± 0.685
4.077IleArg: 4.077 ± 0.615
5.812IleSer: 5.812 ± 0.844
5.952IleThr: 5.952 ± 0.519
5.858IleVal: 5.858 ± 0.638
0.516IleTrp: 0.516 ± 0.154
3.374IleTyr: 3.374 ± 0.561
0.0IleXaa: 0.0 ± 0.0
Lys
4.734LysAla: 4.734 ± 0.56
0.281LysCys: 0.281 ± 0.145
4.546LysAsp: 4.546 ± 0.643
6.468LysGlu: 6.468 ± 0.998
1.781LysPhe: 1.781 ± 0.367
2.062LysGly: 2.062 ± 0.33
1.078LysHis: 1.078 ± 0.258
8.295LysIle: 8.295 ± 1.045
6.186LysLys: 6.186 ± 0.889
9.28LysLeu: 9.28 ± 1.049
1.593LysMet: 1.593 ± 0.254
3.656LysAsn: 3.656 ± 0.572
1.968LysPro: 1.968 ± 0.352
2.203LysGln: 2.203 ± 0.418
3.515LysArg: 3.515 ± 0.685
3.421LysSer: 3.421 ± 0.383
3.843LysThr: 3.843 ± 0.519
5.343LysVal: 5.343 ± 0.651
0.89LysTrp: 0.89 ± 0.2
3.656LysTyr: 3.656 ± 0.623
0.0LysXaa: 0.0 ± 0.0
Leu
7.827LeuAla: 7.827 ± 0.995
0.609LeuCys: 0.609 ± 0.182
4.265LeuAsp: 4.265 ± 0.512
6.843LeuGlu: 6.843 ± 0.932
4.499LeuPhe: 4.499 ± 0.802
3.468LeuGly: 3.468 ± 0.423
1.406LeuHis: 1.406 ± 0.337
8.061LeuIle: 8.061 ± 0.846
8.014LeuLys: 8.014 ± 0.836
12.139LeuLeu: 12.139 ± 0.883
1.968LeuMet: 1.968 ± 0.384
7.124LeuAsn: 7.124 ± 0.746
4.499LeuPro: 4.499 ± 0.56
5.53LeuGln: 5.53 ± 1.339
4.874LeuArg: 4.874 ± 0.583
7.921LeuSer: 7.921 ± 0.729
5.952LeuThr: 5.952 ± 0.534
6.936LeuVal: 6.936 ± 0.674
0.469LeuTrp: 0.469 ± 0.152
4.687LeuTyr: 4.687 ± 0.552
0.0LeuXaa: 0.0 ± 0.0
Met
1.5MetAla: 1.5 ± 0.303
0.094MetCys: 0.094 ± 0.074
0.141MetAsp: 0.141 ± 0.082
1.125MetGlu: 1.125 ± 0.276
0.937MetPhe: 0.937 ± 0.262
0.656MetGly: 0.656 ± 0.169
0.094MetHis: 0.094 ± 0.056
1.968MetIle: 1.968 ± 0.38
1.734MetLys: 1.734 ± 0.308
2.718MetLeu: 2.718 ± 0.431
0.469MetMet: 0.469 ± 0.165
0.844MetAsn: 0.844 ± 0.179
0.937MetPro: 0.937 ± 0.212
1.031MetGln: 1.031 ± 0.248
1.219MetArg: 1.219 ± 0.257
1.453MetSer: 1.453 ± 0.24
1.031MetThr: 1.031 ± 0.253
1.031MetVal: 1.031 ± 0.303
0.234MetTrp: 0.234 ± 0.109
1.078MetTyr: 1.078 ± 0.208
0.0MetXaa: 0.0 ± 0.0
Asn
4.921AsnAla: 4.921 ± 0.791
0.328AsnCys: 0.328 ± 0.127
3.046AsnAsp: 3.046 ± 0.522
4.405AsnGlu: 4.405 ± 0.618
2.109AsnPhe: 2.109 ± 0.252
3.562AsnGly: 3.562 ± 0.599
0.469AsnHis: 0.469 ± 0.158
5.015AsnIle: 5.015 ± 0.55
3.468AsnLys: 3.468 ± 0.548
6.093AsnLeu: 6.093 ± 0.674
0.703AsnMet: 0.703 ± 0.228
4.78AsnAsn: 4.78 ± 0.922
2.671AsnPro: 2.671 ± 0.394
2.531AsnGln: 2.531 ± 0.754
1.265AsnArg: 1.265 ± 0.236
3.328AsnSer: 3.328 ± 0.543
3.984AsnThr: 3.984 ± 0.517
4.968AsnVal: 4.968 ± 0.58
0.562AsnTrp: 0.562 ± 0.132
3.281AsnTyr: 3.281 ± 0.397
0.0AsnXaa: 0.0 ± 0.0
Pro
2.437ProAla: 2.437 ± 0.304
0.187ProCys: 0.187 ± 0.099
1.828ProAsp: 1.828 ± 0.262
2.671ProGlu: 2.671 ± 0.322
1.781ProPhe: 1.781 ± 0.604
1.734ProGly: 1.734 ± 0.5
0.328ProHis: 0.328 ± 0.137
2.953ProIle: 2.953 ± 0.478
1.875ProLys: 1.875 ± 0.369
4.031ProLeu: 4.031 ± 0.533
0.469ProMet: 0.469 ± 0.152
2.578ProAsn: 2.578 ± 0.602
2.953ProPro: 2.953 ± 0.354
2.062ProGln: 2.062 ± 0.402
1.265ProArg: 1.265 ± 0.253
2.859ProSer: 2.859 ± 0.826
2.859ProThr: 2.859 ± 0.497
2.343ProVal: 2.343 ± 0.421
0.234ProTrp: 0.234 ± 0.209
2.578ProTyr: 2.578 ± 0.452
0.0ProXaa: 0.0 ± 0.0
Gln
3.14GlnAla: 3.14 ± 0.83
0.047GlnCys: 0.047 ± 0.047
1.687GlnAsp: 1.687 ± 0.269
2.25GlnGlu: 2.25 ± 0.405
1.219GlnPhe: 1.219 ± 0.231
1.734GlnGly: 1.734 ± 0.287
0.516GlnHis: 0.516 ± 0.185
3.749GlnIle: 3.749 ± 1.11
2.906GlnLys: 2.906 ± 0.411
5.202GlnLeu: 5.202 ± 1.251
0.937GlnMet: 0.937 ± 0.19
3.093GlnAsn: 3.093 ± 0.954
1.5GlnPro: 1.5 ± 0.372
3.749GlnGln: 3.749 ± 1.718
0.937GlnArg: 0.937 ± 0.21
2.39GlnSer: 2.39 ± 0.737
2.578GlnThr: 2.578 ± 0.463
2.39GlnVal: 2.39 ± 0.496
0.375GlnTrp: 0.375 ± 0.122
2.437GlnTyr: 2.437 ± 0.442
0.0GlnXaa: 0.0 ± 0.0
Arg
2.718ArgAla: 2.718 ± 0.344
0.281ArgCys: 0.281 ± 0.115
2.062ArgAsp: 2.062 ± 0.361
3.562ArgGlu: 3.562 ± 0.533
1.593ArgPhe: 1.593 ± 0.313
1.593ArgGly: 1.593 ± 0.261
0.469ArgHis: 0.469 ± 0.154
3.609ArgIle: 3.609 ± 0.457
3.609ArgLys: 3.609 ± 0.728
4.921ArgLeu: 4.921 ± 0.624
0.797ArgMet: 0.797 ± 0.227
1.922ArgAsn: 1.922 ± 0.299
0.75ArgPro: 0.75 ± 0.241
1.172ArgGln: 1.172 ± 0.212
1.922ArgArg: 1.922 ± 0.468
1.453ArgSer: 1.453 ± 0.219
2.015ArgThr: 2.015 ± 0.373
2.343ArgVal: 2.343 ± 0.476
0.047ArgTrp: 0.047 ± 0.044
1.453ArgTyr: 1.453 ± 0.291
0.0ArgXaa: 0.0 ± 0.0
Ser
3.702SerAla: 3.702 ± 0.571
0.187SerCys: 0.187 ± 0.1
2.812SerAsp: 2.812 ± 0.354
2.718SerGlu: 2.718 ± 0.373
2.812SerPhe: 2.812 ± 0.81
3.421SerGly: 3.421 ± 0.79
0.89SerHis: 0.89 ± 0.222
4.265SerIle: 4.265 ± 0.571
3.937SerLys: 3.937 ± 0.473
6.28SerLeu: 6.28 ± 0.64
1.547SerMet: 1.547 ± 0.25
3.281SerAsn: 3.281 ± 0.69
2.953SerPro: 2.953 ± 0.648
3.562SerGln: 3.562 ± 0.941
2.578SerArg: 2.578 ± 0.451
6.186SerSer: 6.186 ± 1.102
5.062SerThr: 5.062 ± 1.035
4.874SerVal: 4.874 ± 0.731
0.422SerTrp: 0.422 ± 0.163
3.14SerTyr: 3.14 ± 0.704
0.0SerXaa: 0.0 ± 0.0
Thr
4.031ThrAla: 4.031 ± 0.508
0.234ThrCys: 0.234 ± 0.113
1.922ThrAsp: 1.922 ± 0.292
2.437ThrGlu: 2.437 ± 0.439
3.187ThrPhe: 3.187 ± 0.641
2.156ThrGly: 2.156 ± 0.395
0.75ThrHis: 0.75 ± 0.198
6.14ThrIle: 6.14 ± 0.553
2.906ThrLys: 2.906 ± 0.402
6.233ThrLeu: 6.233 ± 0.627
1.453ThrMet: 1.453 ± 0.291
3.14ThrAsn: 3.14 ± 0.569
3.328ThrPro: 3.328 ± 0.542
3.14ThrGln: 3.14 ± 0.517
1.875ThrArg: 1.875 ± 0.34
3.89ThrSer: 3.89 ± 0.891
5.202ThrThr: 5.202 ± 1.204
4.218ThrVal: 4.218 ± 0.791
0.234ThrTrp: 0.234 ± 0.097
3.328ThrTyr: 3.328 ± 0.506
0.0ThrXaa: 0.0 ± 0.0
Val
4.499ValAla: 4.499 ± 0.478
0.516ValCys: 0.516 ± 0.153
3.702ValAsp: 3.702 ± 0.439
3.984ValGlu: 3.984 ± 0.407
2.25ValPhe: 2.25 ± 0.408
2.718ValGly: 2.718 ± 0.531
0.75ValHis: 0.75 ± 0.197
5.249ValIle: 5.249 ± 0.693
5.108ValLys: 5.108 ± 0.688
6.374ValLeu: 6.374 ± 0.739
1.219ValMet: 1.219 ± 0.225
4.874ValAsn: 4.874 ± 0.48
2.906ValPro: 2.906 ± 0.509
2.437ValGln: 2.437 ± 0.529
2.859ValArg: 2.859 ± 0.433
5.155ValSer: 5.155 ± 0.985
4.124ValThr: 4.124 ± 0.96
3.562ValVal: 3.562 ± 0.492
0.562ValTrp: 0.562 ± 0.214
3.421ValTyr: 3.421 ± 0.467
0.0ValXaa: 0.0 ± 0.0
Trp
0.328TrpAla: 0.328 ± 0.123
0.047TrpCys: 0.047 ± 0.051
0.328TrpAsp: 0.328 ± 0.126
0.656TrpGlu: 0.656 ± 0.197
0.422TrpPhe: 0.422 ± 0.179
0.562TrpGly: 0.562 ± 0.229
0.047TrpHis: 0.047 ± 0.047
0.469TrpIle: 0.469 ± 0.166
0.656TrpLys: 0.656 ± 0.167
0.703TrpLeu: 0.703 ± 0.204
0.234TrpMet: 0.234 ± 0.121
0.281TrpAsn: 0.281 ± 0.179
0.047TrpPro: 0.047 ± 0.039
0.328TrpGln: 0.328 ± 0.122
0.281TrpArg: 0.281 ± 0.116
0.609TrpSer: 0.609 ± 0.283
0.375TrpThr: 0.375 ± 0.161
0.375TrpVal: 0.375 ± 0.143
0.094TrpTrp: 0.094 ± 0.083
0.422TrpTyr: 0.422 ± 0.212
0.0TrpXaa: 0.0 ± 0.0
Tyr
3.328TyrAla: 3.328 ± 0.358
0.094TyrCys: 0.094 ± 0.075
2.812TyrAsp: 2.812 ± 0.427
2.296TyrGlu: 2.296 ± 0.276
2.765TyrPhe: 2.765 ± 0.434
2.015TyrGly: 2.015 ± 0.367
0.703TyrHis: 0.703 ± 0.25
4.312TyrIle: 4.312 ± 0.534
3.046TyrLys: 3.046 ± 0.432
5.718TyrLeu: 5.718 ± 0.503
0.937TyrMet: 0.937 ± 0.224
3.656TyrAsn: 3.656 ± 0.508
2.203TyrPro: 2.203 ± 0.765
2.062TyrGln: 2.062 ± 0.484
1.593TyrArg: 1.593 ± 0.337
3.234TyrSer: 3.234 ± 0.356
3.234TyrThr: 3.234 ± 0.581
3.562TyrVal: 3.562 ± 0.716
0.516TyrTrp: 0.516 ± 0.18
3.328TyrTyr: 3.328 ± 0.407
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 74 proteins (21338 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski