Amino acid dipepetide frequency for Staphylococcus lentus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.693AlaAla: 3.693 ± 0.094
0.511AlaCys: 0.511 ± 0.027
2.763AlaAsp: 2.763 ± 0.066
3.495AlaGlu: 3.495 ± 0.073
2.984AlaPhe: 2.984 ± 0.069
4.048AlaGly: 4.048 ± 0.078
1.28AlaHis: 1.28 ± 0.043
6.054AlaIle: 6.054 ± 0.098
4.208AlaLys: 4.208 ± 0.077
6.423AlaLeu: 6.423 ± 0.104
1.691AlaMet: 1.691 ± 0.056
2.633AlaAsn: 2.633 ± 0.061
1.669AlaPro: 1.669 ± 0.053
2.104AlaGln: 2.104 ± 0.059
1.974AlaArg: 1.974 ± 0.057
3.706AlaSer: 3.706 ± 0.08
3.297AlaThr: 3.297 ± 0.067
4.12AlaVal: 4.12 ± 0.081
0.439AlaTrp: 0.439 ± 0.027
2.145AlaTyr: 2.145 ± 0.054
0.0AlaXaa: 0.0 ± 0.0
Cys
0.351CysAla: 0.351 ± 0.021
0.076CysCys: 0.076 ± 0.01
0.404CysAsp: 0.404 ± 0.026
0.388CysGlu: 0.388 ± 0.024
0.248CysPhe: 0.248 ± 0.017
0.57CysGly: 0.57 ± 0.03
0.181CysHis: 0.181 ± 0.017
0.549CysIle: 0.549 ± 0.03
0.357CysLys: 0.357 ± 0.021
0.573CysLeu: 0.573 ± 0.028
0.154CysMet: 0.154 ± 0.014
0.264CysAsn: 0.264 ± 0.02
0.31CysPro: 0.31 ± 0.023
0.169CysGln: 0.169 ± 0.018
0.205CysArg: 0.205 ± 0.015
0.429CysSer: 0.429 ± 0.025
0.38CysThr: 0.38 ± 0.022
0.369CysVal: 0.369 ± 0.023
0.035CysTrp: 0.035 ± 0.007
0.243CysTyr: 0.243 ± 0.018
0.0CysXaa: 0.0 ± 0.0
Asp
3.297AspAla: 3.297 ± 0.067
0.333AspCys: 0.333 ± 0.021
3.302AspAsp: 3.302 ± 0.075
5.311AspGlu: 5.311 ± 0.096
2.597AspPhe: 2.597 ± 0.064
3.289AspGly: 3.289 ± 0.072
1.09AspHis: 1.09 ± 0.037
5.369AspIle: 5.369 ± 0.094
4.827AspLys: 4.827 ± 0.095
5.153AspLeu: 5.153 ± 0.082
1.463AspMet: 1.463 ± 0.049
2.815AspAsn: 2.815 ± 0.073
1.532AspPro: 1.532 ± 0.049
1.856AspGln: 1.856 ± 0.052
1.764AspArg: 1.764 ± 0.045
2.968AspSer: 2.968 ± 0.071
2.776AspThr: 2.776 ± 0.07
4.084AspVal: 4.084 ± 0.074
0.468AspTrp: 0.468 ± 0.026
2.656AspTyr: 2.656 ± 0.062
0.0AspXaa: 0.0 ± 0.0
Glu
4.633GluAla: 4.633 ± 0.078
0.333GluCys: 0.333 ± 0.02
4.421GluAsp: 4.421 ± 0.096
6.58GluGlu: 6.58 ± 0.12
2.495GluPhe: 2.495 ± 0.056
3.891GluGly: 3.891 ± 0.073
1.745GluHis: 1.745 ± 0.053
6.215GluIle: 6.215 ± 0.103
6.277GluLys: 6.277 ± 0.109
6.45GluLeu: 6.45 ± 0.113
2.166GluMet: 2.166 ± 0.059
4.523GluAsn: 4.523 ± 0.086
1.88GluPro: 1.88 ± 0.057
3.542GluGln: 3.542 ± 0.074
3.055GluArg: 3.055 ± 0.084
4.017GluSer: 4.017 ± 0.089
4.201GluThr: 4.201 ± 0.082
4.916GluVal: 4.916 ± 0.092
0.66GluTrp: 0.66 ± 0.033
2.589GluTyr: 2.589 ± 0.064
0.0GluXaa: 0.0 ± 0.0
Phe
2.473PheAla: 2.473 ± 0.066
0.317PheCys: 0.317 ± 0.019
2.809PheAsp: 2.809 ± 0.061
3.114PheGlu: 3.114 ± 0.059
2.051PhePhe: 2.051 ± 0.058
3.306PheGly: 3.306 ± 0.078
0.832PheHis: 0.832 ± 0.036
4.715PheIle: 4.715 ± 0.111
3.597PheLys: 3.597 ± 0.069
4.059PheLeu: 4.059 ± 0.093
1.211PheMet: 1.211 ± 0.043
2.845PheAsn: 2.845 ± 0.06
1.246PhePro: 1.246 ± 0.04
1.245PheGln: 1.245 ± 0.039
1.17PheArg: 1.17 ± 0.039
2.845PheSer: 2.845 ± 0.066
2.414PheThr: 2.414 ± 0.062
3.27PheVal: 3.27 ± 0.078
0.374PheTrp: 0.374 ± 0.025
1.773PheTyr: 1.773 ± 0.049
0.0PheXaa: 0.0 ± 0.0
Gly
4.366GlyAla: 4.366 ± 0.098
0.475GlyCys: 0.475 ± 0.029
3.054GlyAsp: 3.054 ± 0.069
4.063GlyGlu: 4.063 ± 0.08
3.148GlyPhe: 3.148 ± 0.085
4.465GlyGly: 4.465 ± 0.1
1.407GlyHis: 1.407 ± 0.048
5.784GlyIle: 5.784 ± 0.105
4.572GlyLys: 4.572 ± 0.087
6.221GlyLeu: 6.221 ± 0.106
1.773GlyMet: 1.773 ± 0.048
2.607GlyAsn: 2.607 ± 0.06
1.724GlyPro: 1.724 ± 0.052
2.103GlyGln: 2.103 ± 0.053
2.149GlyArg: 2.149 ± 0.056
3.715GlySer: 3.715 ± 0.076
3.635GlyThr: 3.635 ± 0.069
4.776GlyVal: 4.776 ± 0.075
0.581GlyTrp: 0.581 ± 0.03
2.821GlyTyr: 2.821 ± 0.061
0.0GlyXaa: 0.0 ± 0.0
His
1.215HisAla: 1.215 ± 0.043
0.131HisCys: 0.131 ± 0.013
1.246HisAsp: 1.246 ± 0.042
1.423HisGlu: 1.423 ± 0.045
1.137HisPhe: 1.137 ± 0.042
1.328HisGly: 1.328 ± 0.043
0.665HisHis: 0.665 ± 0.031
1.874HisIle: 1.874 ± 0.049
1.371HisLys: 1.371 ± 0.039
2.036HisLeu: 2.036 ± 0.048
0.502HisMet: 0.502 ± 0.025
1.094HisAsn: 1.094 ± 0.043
1.007HisPro: 1.007 ± 0.036
0.801HisGln: 0.801 ± 0.033
0.743HisArg: 0.743 ± 0.032
1.119HisSer: 1.119 ± 0.036
1.065HisThr: 1.065 ± 0.042
1.419HisVal: 1.419 ± 0.043
0.166HisTrp: 0.166 ± 0.014
0.983HisTyr: 0.983 ± 0.036
0.0HisXaa: 0.0 ± 0.0
Ile
5.959IleAla: 5.959 ± 0.1
0.673IleCys: 0.673 ± 0.025
5.534IleAsp: 5.534 ± 0.092
6.701IleGlu: 6.701 ± 0.104
4.0IlePhe: 4.0 ± 0.096
6.422IleGly: 6.422 ± 0.12
1.789IleHis: 1.789 ± 0.053
8.188IleIle: 8.188 ± 0.137
6.574IleLys: 6.574 ± 0.099
7.83IleLeu: 7.83 ± 0.13
2.228IleMet: 2.228 ± 0.067
4.955IleAsn: 4.955 ± 0.09
3.14IlePro: 3.14 ± 0.067
3.045IleGln: 3.045 ± 0.076
2.437IleArg: 2.437 ± 0.062
5.688IleSer: 5.688 ± 0.088
4.94IleThr: 4.94 ± 0.09
6.245IleVal: 6.245 ± 0.116
0.596IleTrp: 0.596 ± 0.03
3.03IleTyr: 3.03 ± 0.073
0.0IleXaa: 0.0 ± 0.0
Lys
4.479LysAla: 4.479 ± 0.077
0.372LysCys: 0.372 ± 0.025
5.293LysAsp: 5.293 ± 0.096
7.305LysGlu: 7.305 ± 0.117
2.583LysPhe: 2.583 ± 0.055
4.269LysGly: 4.269 ± 0.083
1.71LysHis: 1.71 ± 0.05
5.392LysIle: 5.392 ± 0.077
6.305LysLys: 6.305 ± 0.121
6.442LysLeu: 6.442 ± 0.095
2.24LysMet: 2.24 ± 0.055
4.374LysAsn: 4.374 ± 0.078
2.367LysPro: 2.367 ± 0.058
3.224LysGln: 3.224 ± 0.066
3.051LysArg: 3.051 ± 0.065
4.58LysSer: 4.58 ± 0.072
3.769LysThr: 3.769 ± 0.081
5.222LysVal: 5.222 ± 0.089
0.689LysTrp: 0.689 ± 0.032
3.121LysTyr: 3.121 ± 0.069
0.0LysXaa: 0.0 ± 0.0
Leu
5.574LeuAla: 5.574 ± 0.101
0.608LeuCys: 0.608 ± 0.03
4.886LeuAsp: 4.886 ± 0.078
6.225LeuGlu: 6.225 ± 0.109
4.622LeuPhe: 4.622 ± 0.112
6.022LeuGly: 6.022 ± 0.111
1.599LeuHis: 1.599 ± 0.045
8.371LeuIle: 8.371 ± 0.134
7.081LeuLys: 7.081 ± 0.095
8.918LeuLeu: 8.918 ± 0.15
2.523LeuMet: 2.523 ± 0.053
5.959LeuAsn: 5.959 ± 0.088
3.565LeuPro: 3.565 ± 0.073
2.755LeuGln: 2.755 ± 0.067
2.748LeuArg: 2.748 ± 0.06
6.827LeuSer: 6.827 ± 0.1
5.377LeuThr: 5.377 ± 0.081
5.655LeuVal: 5.655 ± 0.093
0.63LeuTrp: 0.63 ± 0.029
3.214LeuTyr: 3.214 ± 0.079
0.0LeuXaa: 0.0 ± 0.0
Met
1.616MetAla: 1.616 ± 0.049
0.118MetCys: 0.118 ± 0.013
1.38MetAsp: 1.38 ± 0.037
1.479MetGlu: 1.479 ± 0.045
1.188MetPhe: 1.188 ± 0.039
1.635MetGly: 1.635 ± 0.051
0.488MetHis: 0.488 ± 0.028
2.475MetIle: 2.475 ± 0.055
2.505MetLys: 2.505 ± 0.061
2.446MetLeu: 2.446 ± 0.047
0.834MetMet: 0.834 ± 0.032
1.732MetAsn: 1.732 ± 0.043
0.963MetPro: 0.963 ± 0.039
0.832MetGln: 0.832 ± 0.038
0.925MetArg: 0.925 ± 0.038
1.878MetSer: 1.878 ± 0.06
1.729MetThr: 1.729 ± 0.047
1.553MetVal: 1.553 ± 0.047
0.145MetTrp: 0.145 ± 0.013
0.913MetTyr: 0.913 ± 0.036
0.0MetXaa: 0.0 ± 0.0
Asn
2.932AsnAla: 2.932 ± 0.061
0.295AsnCys: 0.295 ± 0.02
3.372AsnAsp: 3.372 ± 0.072
4.681AsnGlu: 4.681 ± 0.085
2.039AsnPhe: 2.039 ± 0.055
3.183AsnGly: 3.183 ± 0.063
1.383AsnHis: 1.383 ± 0.044
5.215AsnIle: 5.215 ± 0.088
4.808AsnLys: 4.808 ± 0.09
4.428AsnLeu: 4.428 ± 0.077
1.367AsnMet: 1.367 ± 0.042
3.238AsnAsn: 3.238 ± 0.095
2.012AsnPro: 2.012 ± 0.051
2.63AsnGln: 2.63 ± 0.062
1.981AsnArg: 1.981 ± 0.053
2.599AsnSer: 2.599 ± 0.07
2.656AsnThr: 2.656 ± 0.066
3.553AsnVal: 3.553 ± 0.061
0.451AsnTrp: 0.451 ± 0.024
2.176AsnTyr: 2.176 ± 0.056
0.0AsnXaa: 0.0 ± 0.0
Pro
1.606ProAla: 1.606 ± 0.05
0.169ProCys: 0.169 ± 0.018
1.793ProAsp: 1.793 ± 0.058
2.799ProGlu: 2.799 ± 0.066
1.817ProPhe: 1.817 ± 0.052
1.84ProGly: 1.84 ± 0.051
0.71ProHis: 0.71 ± 0.033
2.995ProIle: 2.995 ± 0.073
2.292ProLys: 2.292 ± 0.054
3.081ProLeu: 3.081 ± 0.077
0.799ProMet: 0.799 ± 0.034
1.819ProAsn: 1.819 ± 0.045
0.718ProPro: 0.718 ± 0.033
0.943ProGln: 0.943 ± 0.039
0.879ProArg: 0.879 ± 0.037
2.094ProSer: 2.094 ± 0.048
1.812ProThr: 1.812 ± 0.053
2.335ProVal: 2.335 ± 0.054
0.292ProTrp: 0.292 ± 0.024
1.341ProTyr: 1.341 ± 0.044
0.0ProXaa: 0.0 ± 0.0
Gln
2.106GlnAla: 2.106 ± 0.057
0.149GlnCys: 0.149 ± 0.014
1.985GlnAsp: 1.985 ± 0.054
2.418GlnGlu: 2.418 ± 0.061
1.855GlnPhe: 1.855 ± 0.05
1.914GlnGly: 1.914 ± 0.059
0.845GlnHis: 0.845 ± 0.037
2.971GlnIle: 2.971 ± 0.076
2.505GlnLys: 2.505 ± 0.069
3.701GlnLeu: 3.701 ± 0.085
0.993GlnMet: 0.993 ± 0.038
2.118GlnAsn: 2.118 ± 0.061
1.006GlnPro: 1.006 ± 0.033
1.428GlnGln: 1.428 ± 0.047
1.149GlnArg: 1.149 ± 0.035
2.548GlnSer: 2.548 ± 0.07
2.021GlnThr: 2.021 ± 0.051
2.107GlnVal: 2.107 ± 0.05
0.272GlnTrp: 0.272 ± 0.02
1.614GlnTyr: 1.614 ± 0.047
0.0GlnXaa: 0.0 ± 0.0
Arg
1.832ArgAla: 1.832 ± 0.052
0.162ArgCys: 0.162 ± 0.017
1.925ArgAsp: 1.925 ± 0.048
2.426ArgGlu: 2.426 ± 0.061
1.595ArgPhe: 1.595 ± 0.052
1.937ArgGly: 1.937 ± 0.054
0.728ArgHis: 0.728 ± 0.033
2.784ArgIle: 2.784 ± 0.064
2.729ArgLys: 2.729 ± 0.059
3.122ArgLeu: 3.122 ± 0.076
1.005ArgMet: 1.005 ± 0.041
1.772ArgAsn: 1.772 ± 0.052
1.05ArgPro: 1.05 ± 0.037
1.246ArgGln: 1.246 ± 0.044
1.454ArgArg: 1.454 ± 0.045
1.721ArgSer: 1.721 ± 0.045
1.787ArgThr: 1.787 ± 0.046
2.18ArgVal: 2.18 ± 0.061
0.233ArgTrp: 0.233 ± 0.018
1.465ArgTyr: 1.465 ± 0.042
0.0ArgXaa: 0.0 ± 0.0
Ser
3.228SerAla: 3.228 ± 0.081
0.359SerCys: 0.359 ± 0.024
3.16SerAsp: 3.16 ± 0.07
4.517SerGlu: 4.517 ± 0.094
3.057SerPhe: 3.057 ± 0.07
4.067SerGly: 4.067 ± 0.085
1.335SerHis: 1.335 ± 0.044
5.6SerIle: 5.6 ± 0.079
4.733SerLys: 4.733 ± 0.086
5.867SerLeu: 5.867 ± 0.099
1.593SerMet: 1.593 ± 0.043
3.428SerAsn: 3.428 ± 0.079
1.816SerPro: 1.816 ± 0.052
2.108SerGln: 2.108 ± 0.056
2.051SerArg: 2.051 ± 0.054
3.801SerSer: 3.801 ± 0.081
3.387SerThr: 3.387 ± 0.078
3.87SerVal: 3.87 ± 0.068
0.498SerTrp: 0.498 ± 0.029
2.51SerTyr: 2.51 ± 0.056
0.0SerXaa: 0.0 ± 0.0
Thr
3.239ThrAla: 3.239 ± 0.072
0.35ThrCys: 0.35 ± 0.019
3.014ThrAsp: 3.014 ± 0.069
3.715ThrGlu: 3.715 ± 0.083
2.758ThrPhe: 2.758 ± 0.055
3.829ThrGly: 3.829 ± 0.077
1.153ThrHis: 1.153 ± 0.033
5.078ThrIle: 5.078 ± 0.076
3.746ThrLys: 3.746 ± 0.082
5.298ThrLeu: 5.298 ± 0.085
1.34ThrMet: 1.34 ± 0.043
2.742ThrAsn: 2.742 ± 0.062
2.157ThrPro: 2.157 ± 0.05
1.66ThrGln: 1.66 ± 0.048
1.678ThrArg: 1.678 ± 0.043
3.371ThrSer: 3.371 ± 0.069
3.097ThrThr: 3.097 ± 0.06
3.884ThrVal: 3.884 ± 0.074
0.457ThrTrp: 0.457 ± 0.025
2.114ThrTyr: 2.114 ± 0.053
0.0ThrXaa: 0.0 ± 0.0
Val
4.206ValAla: 4.206 ± 0.083
0.514ValCys: 0.514 ± 0.028
3.874ValAsp: 3.874 ± 0.082
4.65ValGlu: 4.65 ± 0.087
2.994ValPhe: 2.994 ± 0.076
4.424ValGly: 4.424 ± 0.08
1.217ValHis: 1.217 ± 0.04
6.197ValIle: 6.197 ± 0.101
4.918ValLys: 4.918 ± 0.08
6.312ValLeu: 6.312 ± 0.109
1.821ValMet: 1.821 ± 0.052
3.541ValAsn: 3.541 ± 0.073
2.378ValPro: 2.378 ± 0.057
2.059ValGln: 2.059 ± 0.056
2.068ValArg: 2.068 ± 0.061
4.436ValSer: 4.436 ± 0.073
3.887ValThr: 3.887 ± 0.077
4.869ValVal: 4.869 ± 0.086
0.508ValTrp: 0.508 ± 0.026
2.299ValTyr: 2.299 ± 0.059
0.0ValXaa: 0.0 ± 0.0
Trp
0.441TrpAla: 0.441 ± 0.027
0.067TrpCys: 0.067 ± 0.009
0.376TrpAsp: 0.376 ± 0.022
0.406TrpGlu: 0.406 ± 0.023
0.448TrpPhe: 0.448 ± 0.027
0.483TrpGly: 0.483 ± 0.028
0.197TrpHis: 0.197 ± 0.016
0.75TrpIle: 0.75 ± 0.036
0.514TrpLys: 0.514 ± 0.027
0.991TrpLeu: 0.991 ± 0.045
0.28TrpMet: 0.28 ± 0.018
0.409TrpAsn: 0.409 ± 0.026
0.228TrpPro: 0.228 ± 0.017
0.287TrpGln: 0.287 ± 0.021
0.268TrpArg: 0.268 ± 0.019
0.52TrpSer: 0.52 ± 0.026
0.4TrpThr: 0.4 ± 0.023
0.471TrpVal: 0.471 ± 0.025
0.089TrpTrp: 0.089 ± 0.01
0.308TrpTyr: 0.308 ± 0.023
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.99TyrAla: 1.99 ± 0.046
0.243TyrCys: 0.243 ± 0.019
2.362TyrAsp: 2.362 ± 0.058
2.89TyrGlu: 2.89 ± 0.066
2.049TyrPhe: 2.049 ± 0.054
2.516TyrGly: 2.516 ± 0.059
0.972TyrHis: 0.972 ± 0.042
3.399TyrIle: 3.399 ± 0.074
2.866TyrLys: 2.866 ± 0.065
3.808TyrLeu: 3.808 ± 0.072
0.85TyrMet: 0.85 ± 0.03
2.13TyrAsn: 2.13 ± 0.059
1.367TyrPro: 1.367 ± 0.042
1.667TyrGln: 1.667 ± 0.053
1.403TyrArg: 1.403 ± 0.044
2.122TyrSer: 2.122 ± 0.055
2.052TyrThr: 2.052 ± 0.057
2.273TyrVal: 2.273 ± 0.05
0.35TyrTrp: 0.35 ± 0.022
1.709TyrTyr: 1.709 ± 0.052
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 2457 proteins (745563 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski