Amino acid dipepetide frequency for Mycoplasma maculosum

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
2.658AlaAla: 2.658 ± 0.166
0.242AlaCys: 0.242 ± 0.031
2.089AlaAsp: 2.089 ± 0.09
2.886AlaGlu: 2.886 ± 0.157
2.496AlaPhe: 2.496 ± 0.096
2.206AlaGly: 2.206 ± 0.11
0.653AlaHis: 0.653 ± 0.049
5.0AlaIle: 5.0 ± 0.165
5.257AlaLys: 5.257 ± 0.232
4.593AlaLeu: 4.593 ± 0.19
0.877AlaMet: 0.877 ± 0.073
3.565AlaAsn: 3.565 ± 0.13
1.094AlaPro: 1.094 ± 0.062
1.362AlaGln: 1.362 ± 0.08
1.781AlaArg: 1.781 ± 0.107
3.058AlaSer: 3.058 ± 0.106
2.372AlaThr: 2.372 ± 0.113
2.372AlaVal: 2.372 ± 0.109
0.363AlaTrp: 0.363 ± 0.041
1.902AlaTyr: 1.902 ± 0.087
0.0AlaXaa: 0.0 ± 0.0
Cys
0.242CysAla: 0.242 ± 0.031
0.033CysCys: 0.033 ± 0.012
0.228CysAsp: 0.228 ± 0.034
0.268CysGlu: 0.268 ± 0.031
0.169CysPhe: 0.169 ± 0.023
0.279CysGly: 0.279 ± 0.033
0.106CysHis: 0.106 ± 0.02
0.305CysIle: 0.305 ± 0.04
0.29CysLys: 0.29 ± 0.033
0.371CysLeu: 0.371 ± 0.041
0.059CysMet: 0.059 ± 0.015
0.264CysAsn: 0.264 ± 0.03
0.095CysPro: 0.095 ± 0.019
0.088CysGln: 0.088 ± 0.019
0.132CysArg: 0.132 ± 0.025
0.415CysSer: 0.415 ± 0.033
0.184CysThr: 0.184 ± 0.027
0.165CysVal: 0.165 ± 0.024
0.044CysTrp: 0.044 ± 0.012
0.213CysTyr: 0.213 ± 0.03
0.0CysXaa: 0.0 ± 0.0
Asp
2.452AspAla: 2.452 ± 0.145
0.125AspCys: 0.125 ± 0.019
2.676AspAsp: 2.676 ± 0.113
4.662AspGlu: 4.662 ± 0.16
3.752AspPhe: 3.752 ± 0.133
2.089AspGly: 2.089 ± 0.111
0.558AspHis: 0.558 ± 0.047
5.364AspIle: 5.364 ± 0.148
5.834AspLys: 5.834 ± 0.168
5.635AspLeu: 5.635 ± 0.153
0.624AspMet: 0.624 ± 0.052
4.435AspAsn: 4.435 ± 0.168
1.351AspPro: 1.351 ± 0.082
1.498AspGln: 1.498 ± 0.079
1.435AspArg: 1.435 ± 0.082
3.646AspSer: 3.646 ± 0.129
2.089AspThr: 2.089 ± 0.119
2.585AspVal: 2.585 ± 0.102
0.536AspTrp: 0.536 ± 0.039
2.86AspTyr: 2.86 ± 0.109
0.0AspXaa: 0.0 ± 0.0
Glu
3.936GluAla: 3.936 ± 0.19
0.176GluCys: 0.176 ± 0.028
3.319GluAsp: 3.319 ± 0.126
6.094GluGlu: 6.094 ± 0.176
3.925GluPhe: 3.925 ± 0.125
2.306GluGly: 2.306 ± 0.111
0.734GluHis: 0.734 ± 0.052
8.624GluIle: 8.624 ± 0.205
9.035GluLys: 9.035 ± 0.217
7.904GluLeu: 7.904 ± 0.209
1.311GluMet: 1.311 ± 0.073
7.706GluAsn: 7.706 ± 0.213
1.296GluPro: 1.296 ± 0.079
2.144GluGln: 2.144 ± 0.1
1.935GluArg: 1.935 ± 0.097
3.936GluSer: 3.936 ± 0.139
3.403GluThr: 3.403 ± 0.126
3.352GluVal: 3.352 ± 0.125
0.554GluTrp: 0.554 ± 0.041
3.227GluTyr: 3.227 ± 0.122
0.0GluXaa: 0.0 ± 0.0
Phe
2.526PheAla: 2.526 ± 0.101
0.257PheCys: 0.257 ± 0.031
3.488PheAsp: 3.488 ± 0.119
3.972PheGlu: 3.972 ± 0.144
2.724PhePhe: 2.724 ± 0.127
2.684PheGly: 2.684 ± 0.112
0.463PheHis: 0.463 ± 0.048
5.812PheIle: 5.812 ± 0.204
5.76PheLys: 5.76 ± 0.17
5.074PheLeu: 5.074 ± 0.164
0.837PheMet: 0.837 ± 0.059
5.147PheAsn: 5.147 ± 0.181
1.028PhePro: 1.028 ± 0.065
1.076PheGln: 1.076 ± 0.082
1.23PheArg: 1.23 ± 0.057
4.046PheSer: 4.046 ± 0.142
2.46PheThr: 2.46 ± 0.093
2.919PheVal: 2.919 ± 0.117
0.554PheTrp: 0.554 ± 0.054
2.485PheTyr: 2.485 ± 0.114
0.0PheXaa: 0.0 ± 0.0
Gly
2.184GlyAla: 2.184 ± 0.116
0.184GlyCys: 0.184 ± 0.029
1.986GlyAsp: 1.986 ± 0.096
2.574GlyGlu: 2.574 ± 0.122
2.423GlyPhe: 2.423 ± 0.092
2.419GlyGly: 2.419 ± 0.129
0.731GlyHis: 0.731 ± 0.059
4.255GlyIle: 4.255 ± 0.164
4.024GlyLys: 4.024 ± 0.141
3.998GlyLeu: 3.998 ± 0.146
0.826GlyMet: 0.826 ± 0.059
2.706GlyAsn: 2.706 ± 0.108
0.822GlyPro: 0.822 ± 0.065
1.226GlyGln: 1.226 ± 0.077
1.373GlyArg: 1.373 ± 0.08
2.779GlySer: 2.779 ± 0.132
2.614GlyThr: 2.614 ± 0.104
2.489GlyVal: 2.489 ± 0.111
0.4GlyTrp: 0.4 ± 0.036
1.997GlyTyr: 1.997 ± 0.086
0.0GlyXaa: 0.0 ± 0.0
His
0.591HisAla: 0.591 ± 0.056
0.051HisCys: 0.051 ± 0.015
0.576HisAsp: 0.576 ± 0.048
0.782HisGlu: 0.782 ± 0.067
0.723HisPhe: 0.723 ± 0.057
0.672HisGly: 0.672 ± 0.054
0.217HisHis: 0.217 ± 0.032
1.116HisIle: 1.116 ± 0.065
1.006HisLys: 1.006 ± 0.066
1.079HisLeu: 1.079 ± 0.073
0.176HisMet: 0.176 ± 0.022
0.877HisAsn: 0.877 ± 0.064
0.47HisPro: 0.47 ± 0.044
0.253HisGln: 0.253 ± 0.038
0.334HisArg: 0.334 ± 0.036
0.76HisSer: 0.76 ± 0.053
0.543HisThr: 0.543 ± 0.047
0.613HisVal: 0.613 ± 0.056
0.095HisTrp: 0.095 ± 0.02
0.536HisTyr: 0.536 ± 0.043
0.0HisXaa: 0.0 ± 0.0
Ile
4.563IleAla: 4.563 ± 0.166
0.481IleCys: 0.481 ± 0.043
6.597IleAsp: 6.597 ± 0.169
7.192IleGlu: 7.192 ± 0.19
5.459IlePhe: 5.459 ± 0.183
3.917IleGly: 3.917 ± 0.146
1.017IleHis: 1.017 ± 0.069
9.901IleIle: 9.901 ± 0.263
11.201IleLys: 11.201 ± 0.244
9.354IleLeu: 9.354 ± 0.245
1.472IleMet: 1.472 ± 0.081
10.72IleAsn: 10.72 ± 0.366
2.64IlePro: 2.64 ± 0.111
2.511IleGln: 2.511 ± 0.117
2.797IleArg: 2.797 ± 0.107
7.981IleSer: 7.981 ± 0.206
4.861IleThr: 4.861 ± 0.136
5.052IleVal: 5.052 ± 0.154
0.833IleTrp: 0.833 ± 0.06
3.943IleTyr: 3.943 ± 0.136
0.0IleXaa: 0.0 ± 0.0
Lys
4.71LysAla: 4.71 ± 0.194
0.349LysCys: 0.349 ± 0.038
5.628LysAsp: 5.628 ± 0.178
9.538LysGlu: 9.538 ± 0.205
4.743LysPhe: 4.743 ± 0.146
3.414LysGly: 3.414 ± 0.119
1.237LysHis: 1.237 ± 0.077
12.126LysIle: 12.126 ± 0.272
10.547LysLys: 10.547 ± 0.242
9.332LysLeu: 9.332 ± 0.198
2.28LysMet: 2.28 ± 0.11
11.454LysAsn: 11.454 ± 0.305
2.386LysPro: 2.386 ± 0.107
3.143LysGln: 3.143 ± 0.12
2.959LysArg: 2.959 ± 0.094
5.723LysSer: 5.723 ± 0.128
5.503LysThr: 5.503 ± 0.162
5.176LysVal: 5.176 ± 0.147
1.098LysTrp: 1.098 ± 0.061
5.272LysTyr: 5.272 ± 0.16
0.0LysXaa: 0.0 ± 0.0
Leu
4.527LeuAla: 4.527 ± 0.148
0.382LeuCys: 0.382 ± 0.042
5.393LeuAsp: 5.393 ± 0.156
7.262LeuGlu: 7.262 ± 0.19
5.228LeuPhe: 5.228 ± 0.151
3.939LeuGly: 3.939 ± 0.133
0.921LeuHis: 0.921 ± 0.06
9.839LeuIle: 9.839 ± 0.244
10.144LeuLys: 10.144 ± 0.24
8.433LeuLeu: 8.433 ± 0.211
1.472LeuMet: 1.472 ± 0.069
9.152LeuAsn: 9.152 ± 0.258
2.64LeuPro: 2.64 ± 0.1
2.14LeuGln: 2.14 ± 0.098
2.658LeuArg: 2.658 ± 0.105
7.056LeuSer: 7.056 ± 0.165
4.813LeuThr: 4.813 ± 0.137
5.033LeuVal: 5.033 ± 0.144
0.753LeuTrp: 0.753 ± 0.057
3.025LeuTyr: 3.025 ± 0.122
0.0LeuXaa: 0.0 ± 0.0
Met
0.819MetAla: 0.819 ± 0.061
0.055MetCys: 0.055 ± 0.015
0.749MetAsp: 0.749 ± 0.054
0.8MetGlu: 0.8 ± 0.049
0.848MetPhe: 0.848 ± 0.06
0.635MetGly: 0.635 ± 0.056
0.272MetHis: 0.272 ± 0.031
1.446MetIle: 1.446 ± 0.084
1.81MetLys: 1.81 ± 0.085
1.542MetLeu: 1.542 ± 0.078
0.327MetMet: 0.327 ± 0.034
1.549MetAsn: 1.549 ± 0.069
0.69MetPro: 0.69 ± 0.054
0.551MetGln: 0.551 ± 0.044
0.444MetArg: 0.444 ± 0.04
1.178MetSer: 1.178 ± 0.069
0.716MetThr: 0.716 ± 0.056
0.786MetVal: 0.786 ± 0.061
0.136MetTrp: 0.136 ± 0.021
0.558MetTyr: 0.558 ± 0.051
0.0MetXaa: 0.0 ± 0.0
Asn
3.715AsnAla: 3.715 ± 0.158
0.272AsnCys: 0.272 ± 0.034
5.331AsnAsp: 5.331 ± 0.19
7.61AsnGlu: 7.61 ± 0.249
4.82AsnPhe: 4.82 ± 0.17
3.789AsnGly: 3.789 ± 0.118
0.962AsnHis: 0.962 ± 0.054
9.299AsnIle: 9.299 ± 0.326
10.896AsnLys: 10.896 ± 0.24
8.715AsnLeu: 8.715 ± 0.325
1.329AsnMet: 1.329 ± 0.079
10.301AsnAsn: 10.301 ± 0.407
2.684AsnPro: 2.684 ± 0.121
2.566AsnGln: 2.566 ± 0.14
2.261AsnArg: 2.261 ± 0.109
6.968AsnSer: 6.968 ± 0.339
3.737AsnThr: 3.737 ± 0.146
4.134AsnVal: 4.134 ± 0.141
0.767AsnTrp: 0.767 ± 0.059
4.394AsnTyr: 4.394 ± 0.142
0.0AsnXaa: 0.0 ± 0.0
Pro
1.223ProAla: 1.223 ± 0.079
0.084ProCys: 0.084 ± 0.018
1.134ProAsp: 1.134 ± 0.063
2.129ProGlu: 2.129 ± 0.106
1.325ProPhe: 1.325 ± 0.075
1.274ProGly: 1.274 ± 0.076
0.396ProHis: 0.396 ± 0.042
2.287ProIle: 2.287 ± 0.09
2.408ProLys: 2.408 ± 0.106
2.225ProLeu: 2.225 ± 0.088
0.352ProMet: 0.352 ± 0.048
2.104ProAsn: 2.104 ± 0.09
0.503ProPro: 0.503 ± 0.053
0.584ProGln: 0.584 ± 0.05
0.587ProArg: 0.587 ± 0.05
1.781ProSer: 1.781 ± 0.094
1.582ProThr: 1.582 ± 0.084
1.3ProVal: 1.3 ± 0.09
0.279ProTrp: 0.279 ± 0.031
1.208ProTyr: 1.208 ± 0.08
0.0ProXaa: 0.0 ± 0.0
Gln
1.454GlnAla: 1.454 ± 0.102
0.059GlnCys: 0.059 ± 0.014
1.322GlnAsp: 1.322 ± 0.078
1.883GlnGlu: 1.883 ± 0.104
1.186GlnPhe: 1.186 ± 0.06
1.035GlnGly: 1.035 ± 0.067
0.275GlnHis: 0.275 ± 0.03
2.959GlnIle: 2.959 ± 0.113
3.007GlnLys: 3.007 ± 0.119
2.383GlnLeu: 2.383 ± 0.106
0.433GlnMet: 0.433 ± 0.041
2.779GlnAsn: 2.779 ± 0.143
0.573GlnPro: 0.573 ± 0.042
0.683GlnGln: 0.683 ± 0.052
0.903GlnArg: 0.903 ± 0.067
1.468GlnSer: 1.468 ± 0.081
1.344GlnThr: 1.344 ± 0.081
1.189GlnVal: 1.189 ± 0.069
0.213GlnTrp: 0.213 ± 0.027
1.057GlnTyr: 1.057 ± 0.07
0.0GlnXaa: 0.0 ± 0.0
Arg
1.435ArgAla: 1.435 ± 0.091
0.117ArgCys: 0.117 ± 0.023
1.557ArgAsp: 1.557 ± 0.068
2.214ArgGlu: 2.214 ± 0.103
1.38ArgPhe: 1.38 ± 0.066
1.263ArgGly: 1.263 ± 0.073
0.411ArgHis: 0.411 ± 0.038
2.9ArgIle: 2.9 ± 0.123
2.838ArgLys: 2.838 ± 0.105
2.537ArgLeu: 2.537 ± 0.105
0.507ArgMet: 0.507 ± 0.046
2.401ArgAsn: 2.401 ± 0.107
0.69ArgPro: 0.69 ± 0.061
0.855ArgGln: 0.855 ± 0.063
1.046ArgArg: 1.046 ± 0.069
1.487ArgSer: 1.487 ± 0.08
1.461ArgThr: 1.461 ± 0.084
1.509ArgVal: 1.509 ± 0.083
0.25ArgTrp: 0.25 ± 0.031
1.285ArgTyr: 1.285 ± 0.076
0.0ArgXaa: 0.0 ± 0.0
Ser
2.783SerAla: 2.783 ± 0.126
0.396SerCys: 0.396 ± 0.038
3.539SerAsp: 3.539 ± 0.113
4.82SerGlu: 4.82 ± 0.145
4.204SerPhe: 4.204 ± 0.136
3.322SerGly: 3.322 ± 0.137
0.789SerHis: 0.789 ± 0.058
6.674SerIle: 6.674 ± 0.181
7.141SerLys: 7.141 ± 0.174
7.258SerLeu: 7.258 ± 0.174
0.841SerMet: 0.841 ± 0.056
6.377SerAsn: 6.377 ± 0.224
1.402SerPro: 1.402 ± 0.074
1.814SerGln: 1.814 ± 0.083
1.876SerArg: 1.876 ± 0.093
5.037SerSer: 5.037 ± 0.151
3.44SerThr: 3.44 ± 0.122
3.198SerVal: 3.198 ± 0.13
0.62SerTrp: 0.62 ± 0.052
2.845SerTyr: 2.845 ± 0.107
0.0SerXaa: 0.0 ± 0.0
Thr
2.001ThrAla: 2.001 ± 0.097
0.191ThrCys: 0.191 ± 0.032
2.489ThrAsp: 2.489 ± 0.12
2.856ThrGlu: 2.856 ± 0.122
2.944ThrPhe: 2.944 ± 0.111
2.247ThrGly: 2.247 ± 0.106
0.646ThrHis: 0.646 ± 0.047
5.276ThrIle: 5.276 ± 0.145
4.908ThrLys: 4.908 ± 0.124
4.644ThrLeu: 4.644 ± 0.142
0.642ThrMet: 0.642 ± 0.051
4.655ThrAsn: 4.655 ± 0.168
1.608ThrPro: 1.608 ± 0.097
1.219ThrGln: 1.219 ± 0.07
1.45ThrArg: 1.45 ± 0.088
3.389ThrSer: 3.389 ± 0.126
2.823ThrThr: 2.823 ± 0.135
2.375ThrVal: 2.375 ± 0.107
0.338ThrTrp: 0.338 ± 0.029
2.004ThrTyr: 2.004 ± 0.1
0.0ThrXaa: 0.0 ± 0.0
Val
2.673ValAla: 2.673 ± 0.12
0.286ValCys: 0.286 ± 0.034
3.165ValAsp: 3.165 ± 0.117
3.517ValGlu: 3.517 ± 0.128
2.713ValPhe: 2.713 ± 0.111
2.364ValGly: 2.364 ± 0.113
0.573ValHis: 0.573 ± 0.051
4.431ValIle: 4.431 ± 0.146
5.03ValLys: 5.03 ± 0.148
4.729ValLeu: 4.729 ± 0.123
0.76ValMet: 0.76 ± 0.055
3.899ValAsn: 3.899 ± 0.134
1.355ValPro: 1.355 ± 0.067
1.252ValGln: 1.252 ± 0.071
1.333ValArg: 1.333 ± 0.081
3.866ValSer: 3.866 ± 0.13
2.353ValThr: 2.353 ± 0.11
2.669ValVal: 2.669 ± 0.112
0.419ValTrp: 0.419 ± 0.042
2.008ValTyr: 2.008 ± 0.084
0.0ValXaa: 0.0 ± 0.0
Trp
0.363TrpAla: 0.363 ± 0.04
0.033TrpCys: 0.033 ± 0.011
0.374TrpAsp: 0.374 ± 0.035
0.609TrpGlu: 0.609 ± 0.047
0.653TrpPhe: 0.653 ± 0.053
0.396TrpGly: 0.396 ± 0.029
0.062TrpHis: 0.062 ± 0.013
0.91TrpIle: 0.91 ± 0.058
0.775TrpLys: 0.775 ± 0.057
0.808TrpLeu: 0.808 ± 0.055
0.195TrpMet: 0.195 ± 0.025
0.844TrpAsn: 0.844 ± 0.056
0.253TrpPro: 0.253 ± 0.038
0.22TrpGln: 0.22 ± 0.026
0.279TrpArg: 0.279 ± 0.033
0.477TrpSer: 0.477 ± 0.041
0.507TrpThr: 0.507 ± 0.043
0.463TrpVal: 0.463 ± 0.041
0.136TrpTrp: 0.136 ± 0.021
0.485TrpTyr: 0.485 ± 0.043
0.0TrpXaa: 0.0 ± 0.0
Tyr
1.971TyrAla: 1.971 ± 0.1
0.176TyrCys: 0.176 ± 0.024
2.566TyrAsp: 2.566 ± 0.109
3.245TyrGlu: 3.245 ± 0.113
2.823TyrPhe: 2.823 ± 0.121
1.759TyrGly: 1.759 ± 0.093
0.448TyrHis: 0.448 ± 0.041
3.969TyrIle: 3.969 ± 0.128
4.714TyrLys: 4.714 ± 0.137
4.196TyrLeu: 4.196 ± 0.163
0.587TyrMet: 0.587 ± 0.046
3.616TyrAsn: 3.616 ± 0.125
1.186TyrPro: 1.186 ± 0.079
1.021TyrGln: 1.021 ± 0.062
1.329TyrArg: 1.329 ± 0.069
3.326TyrSer: 3.326 ± 0.124
1.902TyrThr: 1.902 ± 0.071
2.015TyrVal: 2.015 ± 0.085
0.455TyrTrp: 0.455 ± 0.05
1.957TyrTyr: 1.957 ± 0.097
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 737 proteins (272390 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski