Amino acid dipepetide frequency for Actinoplanes awajinensis subsp. mycoplanecinus

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	23.537AlaAla: 23.537 ± 0.147	0.936AlaCys: 0.936 ± 0.017	8.622AlaAsp: 8.622 ± 0.061	8.153AlaGlu: 8.153 ± 0.066	3.507AlaPhe: 3.507 ± 0.037	15.098AlaGly: 15.098 ± 0.077	2.473AlaHis: 2.473 ± 0.029	4.594AlaIle: 4.594 ± 0.04	2.586AlaLys: 2.586 ± 0.043	14.329AlaLeu: 14.329 ± 0.085	2.539AlaMet: 2.539 ± 0.029	2.269AlaAsn: 2.269 ± 0.032	6.811AlaPro: 6.811 ± 0.062	3.685AlaGln: 3.685 ± 0.04	9.516AlaArg: 9.516 ± 0.068	5.892AlaSer: 5.892 ± 0.053	8.55AlaThr: 8.55 ± 0.07	12.578AlaVal: 12.578 ± 0.075	1.949AlaTrp: 1.949 ± 0.029	2.731AlaTyr: 2.731 ± 0.034	0.0AlaXaa: 0.0 ± 0.0
Cys	0.923CysAla: 0.923 ± 0.018	0.085CysCys: 0.085 ± 0.005	0.437CysAsp: 0.437 ± 0.012	0.304CysGlu: 0.304 ± 0.011	0.191CysPhe: 0.191 ± 0.008	0.822CysGly: 0.822 ± 0.017	0.165CysHis: 0.165 ± 0.007	0.151CysIle: 0.151 ± 0.007	0.116CysLys: 0.116 ± 0.006	0.705CysLeu: 0.705 ± 0.018	0.103CysMet: 0.103 ± 0.005	0.131CysAsn: 0.131 ± 0.007	0.448CysPro: 0.448 ± 0.013	0.171CysGln: 0.171 ± 0.007	0.539CysArg: 0.539 ± 0.013	0.391CysSer: 0.391 ± 0.013	0.463CysThr: 0.463 ± 0.013	0.548CysVal: 0.548 ± 0.013	0.13CysTrp: 0.13 ± 0.007	0.145CysTyr: 0.145 ± 0.007	0.0CysXaa: 0.0 ± 0.0
Asp	7.41AspAla: 7.41 ± 0.058	0.394AspCys: 0.394 ± 0.011	3.917AspAsp: 3.917 ± 0.041	3.654AspGlu: 3.654 ± 0.036	1.617AspPhe: 1.617 ± 0.023	6.201AspGly: 6.201 ± 0.054	1.358AspHis: 1.358 ± 0.024	1.713AspIle: 1.713 ± 0.024	1.072AspLys: 1.072 ± 0.022	6.905AspLeu: 6.905 ± 0.05	0.745AspMet: 0.745 ± 0.015	1.03AspAsn: 1.03 ± 0.02	4.659AspPro: 4.659 ± 0.036	1.898AspGln: 1.898 ± 0.025	5.145AspArg: 5.145 ± 0.043	2.359AspSer: 2.359 ± 0.029	3.104AspThr: 3.104 ± 0.034	4.894AspVal: 4.894 ± 0.037	0.992AspTrp: 0.992 ± 0.018	1.182AspTyr: 1.182 ± 0.017	0.0AspXaa: 0.0 ± 0.0
Glu	6.105GluAla: 6.105 ± 0.049	0.28GluCys: 0.28 ± 0.009	2.167GluAsp: 2.167 ± 0.026	2.235GluGlu: 2.235 ± 0.036	1.422GluPhe: 1.422 ± 0.021	2.941GluGly: 2.941 ± 0.035	1.401GluHis: 1.401 ± 0.021	2.359GluIle: 2.359 ± 0.03	1.155GluLys: 1.155 ± 0.026	6.097GluLeu: 6.097 ± 0.055	0.88GluMet: 0.88 ± 0.017	0.945GluAsn: 0.945 ± 0.018	3.206GluPro: 3.206 ± 0.043	2.298GluGln: 2.298 ± 0.03	4.452GluArg: 4.452 ± 0.044	2.317GluSer: 2.317 ± 0.03	2.662GluThr: 2.662 ± 0.031	4.19GluVal: 4.19 ± 0.038	0.679GluTrp: 0.679 ± 0.016	0.989GluTyr: 0.989 ± 0.02	0.0GluXaa: 0.0 ± 0.0
Phe	3.984PheAla: 3.984 ± 0.038	0.258PheCys: 0.258 ± 0.01	2.025PheAsp: 2.025 ± 0.024	1.239PheGlu: 1.239 ± 0.02	0.849PhePhe: 0.849 ± 0.018	3.119PheGly: 3.119 ± 0.037	0.584PheHis: 0.584 ± 0.015	0.728PheIle: 0.728 ± 0.016	0.46PheLys: 0.46 ± 0.011	2.632PheLeu: 2.632 ± 0.034	0.351PheMet: 0.351 ± 0.009	0.587PheAsn: 0.587 ± 0.015	1.421PhePro: 1.421 ± 0.023	0.737PheGln: 0.737 ± 0.015	1.904PheArg: 1.904 ± 0.023	1.417PheSer: 1.417 ± 0.021	2.124PheThr: 2.124 ± 0.025	2.27PheVal: 2.27 ± 0.025	0.466PheTrp: 0.466 ± 0.013	0.639PheTyr: 0.639 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	10.996GlyAla: 10.996 ± 0.077	0.76GlyCys: 0.76 ± 0.017	5.485GlyAsp: 5.485 ± 0.043	4.424GlyGlu: 4.424 ± 0.036	2.957GlyPhe: 2.957 ± 0.036	8.392GlyGly: 8.392 ± 0.076	2.191GlyHis: 2.191 ± 0.028	3.405GlyIle: 3.405 ± 0.037	2.193GlyLys: 2.193 ± 0.032	9.743GlyLeu: 9.743 ± 0.062	1.822GlyMet: 1.822 ± 0.025	1.924GlyAsn: 1.924 ± 0.033	4.965GlyPro: 4.965 ± 0.053	2.69GlyGln: 2.69 ± 0.031	7.26GlyArg: 7.26 ± 0.055	5.103GlySer: 5.103 ± 0.051	6.365GlyThr: 6.365 ± 0.068	7.8GlyVal: 7.8 ± 0.064	1.901GlyTrp: 1.901 ± 0.026	2.459GlyTyr: 2.459 ± 0.03	0.0GlyXaa: 0.0 ± 0.0
His	2.51HisAla: 2.51 ± 0.027	0.189HisCys: 0.189 ± 0.008	1.385HisAsp: 1.385 ± 0.023	1.07HisGlu: 1.07 ± 0.02	0.599HisPhe: 0.599 ± 0.014	2.134HisGly: 2.134 ± 0.029	0.656HisHis: 0.656 ± 0.016	0.562HisIle: 0.562 ± 0.015	0.265HisLys: 0.265 ± 0.009	2.496HisLeu: 2.496 ± 0.029	0.295HisMet: 0.295 ± 0.012	0.35HisAsn: 0.35 ± 0.009	1.718HisPro: 1.718 ± 0.026	0.663HisGln: 0.663 ± 0.014	2.062HisArg: 2.062 ± 0.029	0.849HisSer: 0.849 ± 0.016	1.163HisThr: 1.163 ± 0.02	1.607HisVal: 1.607 ± 0.021	0.344HisTrp: 0.344 ± 0.01	0.438HisTyr: 0.438 ± 0.012	0.0HisXaa: 0.0 ± 0.0
Ile	5.538IleAla: 5.538 ± 0.04	0.297IleCys: 0.297 ± 0.01	2.528IleAsp: 2.528 ± 0.029	2.019IleGlu: 2.019 ± 0.025	0.911IlePhe: 0.911 ± 0.018	3.985IleGly: 3.985 ± 0.036	0.566IleHis: 0.566 ± 0.014	1.099IleIle: 1.099 ± 0.021	0.753IleLys: 0.753 ± 0.018	2.799IleLeu: 2.799 ± 0.033	0.49IleMet: 0.49 ± 0.012	0.833IleAsn: 0.833 ± 0.017	1.884IlePro: 1.884 ± 0.027	0.764IleGln: 0.764 ± 0.016	2.662IleArg: 2.662 ± 0.029	1.992IleSer: 1.992 ± 0.029	2.78IleThr: 2.78 ± 0.035	3.163IleVal: 3.163 ± 0.032	0.476IleTrp: 0.476 ± 0.013	0.652IleTyr: 0.652 ± 0.015	0.0IleXaa: 0.0 ± 0.0
Lys	2.412LysAla: 2.412 ± 0.036	0.109LysCys: 0.109 ± 0.007	1.001LysAsp: 1.001 ± 0.02	0.769LysGlu: 0.769 ± 0.018	0.471LysPhe: 0.471 ± 0.013	1.36LysGly: 1.36 ± 0.026	0.4LysHis: 0.4 ± 0.013	0.942LysIle: 0.942 ± 0.02	0.599LysLys: 0.599 ± 0.018	1.972LysLeu: 1.972 ± 0.029	0.352LysMet: 0.352 ± 0.011	0.534LysAsn: 0.534 ± 0.014	1.245LysPro: 1.245 ± 0.024	0.673LysGln: 0.673 ± 0.017	1.279LysArg: 1.279 ± 0.023	1.042LysSer: 1.042 ± 0.021	1.243LysThr: 1.243 ± 0.024	1.697LysVal: 1.697 ± 0.027	0.263LysTrp: 0.263 ± 0.009	0.441LysTyr: 0.441 ± 0.013	0.0LysXaa: 0.0 ± 0.0
Leu	15.957LeuAla: 15.957 ± 0.101	0.711LeuCys: 0.711 ± 0.016	6.785LeuAsp: 6.785 ± 0.053	3.995LeuGlu: 3.995 ± 0.04	2.707LeuPhe: 2.707 ± 0.031	9.306LeuGly: 9.306 ± 0.068	2.248LeuHis: 2.248 ± 0.028	4.28LeuIle: 4.28 ± 0.044	1.631LeuLys: 1.631 ± 0.027	11.705LeuLeu: 11.705 ± 0.087	1.538LeuMet: 1.538 ± 0.02	1.829LeuAsn: 1.829 ± 0.026	6.45LeuPro: 6.45 ± 0.048	2.359LeuGln: 2.359 ± 0.027	8.769LeuArg: 8.769 ± 0.059	5.479LeuSer: 5.479 ± 0.045	7.713LeuThr: 7.713 ± 0.054	8.956LeuVal: 8.956 ± 0.07	1.307LeuTrp: 1.307 ± 0.024	1.692LeuTyr: 1.692 ± 0.025	0.0LeuXaa: 0.0 ± 0.0
Met	2.167MetAla: 2.167 ± 0.029	0.109MetCys: 0.109 ± 0.006	0.792MetAsp: 0.792 ± 0.016	0.575MetGlu: 0.575 ± 0.015	0.475MetPhe: 0.475 ± 0.012	1.1MetGly: 1.1 ± 0.018	0.343MetHis: 0.343 ± 0.011	0.838MetIle: 0.838 ± 0.018	0.342MetLys: 0.342 ± 0.01	1.885MetLeu: 1.885 ± 0.028	0.301MetMet: 0.301 ± 0.011	0.398MetAsn: 0.398 ± 0.012	1.128MetPro: 1.128 ± 0.017	0.444MetGln: 0.444 ± 0.012	1.407MetArg: 1.407 ± 0.022	1.225MetSer: 1.225 ± 0.021	1.658MetThr: 1.658 ± 0.024	1.321MetVal: 1.321 ± 0.02	0.2MetTrp: 0.2 ± 0.008	0.283MetTyr: 0.283 ± 0.011	0.0MetXaa: 0.0 ± 0.0
Asn	2.367AsnAla: 2.367 ± 0.033	0.164AsnCys: 0.164 ± 0.008	1.092AsnAsp: 1.092 ± 0.023	0.766AsnGlu: 0.766 ± 0.015	0.494AsnPhe: 0.494 ± 0.015	2.088AsnGly: 2.088 ± 0.036	0.376AsnHis: 0.376 ± 0.011	0.627AsnIle: 0.627 ± 0.017	0.392AsnLys: 0.392 ± 0.012	1.912AsnLeu: 1.912 ± 0.028	0.299AsnMet: 0.299 ± 0.01	0.512AsnAsn: 0.512 ± 0.014	1.431AsnPro: 1.431 ± 0.022	0.593AsnGln: 0.593 ± 0.017	1.477AsnArg: 1.477 ± 0.021	0.953AsnSer: 0.953 ± 0.02	1.212AsnThr: 1.212 ± 0.027	1.49AsnVal: 1.49 ± 0.022	0.329AsnTrp: 0.329 ± 0.01	0.441AsnTyr: 0.441 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	9.852ProAla: 9.852 ± 0.071	0.263ProCys: 0.263 ± 0.01	4.546ProAsp: 4.546 ± 0.043	3.642ProGlu: 3.642 ± 0.043	1.499ProPhe: 1.499 ± 0.019	6.515ProGly: 6.515 ± 0.055	1.139ProHis: 1.139 ± 0.02	1.894ProIle: 1.894 ± 0.027	0.971ProLys: 0.971 ± 0.021	5.019ProLeu: 5.019 ± 0.047	1.057ProMet: 1.057 ± 0.02	0.964ProAsn: 0.964 ± 0.019	3.506ProPro: 3.506 ± 0.053	1.59ProGln: 1.59 ± 0.023	3.526ProArg: 3.526 ± 0.038	3.206ProSer: 3.206 ± 0.048	3.17ProThr: 3.17 ± 0.042	5.54ProVal: 5.54 ± 0.046	0.923ProTrp: 0.923 ± 0.018	1.182ProTyr: 1.182 ± 0.019	0.0ProXaa: 0.0 ± 0.0
Gln	3.967GlnAla: 3.967 ± 0.041	0.155GlnCys: 0.155 ± 0.007	1.285GlnAsp: 1.285 ± 0.022	1.201GlnGlu: 1.201 ± 0.021	0.781GlnPhe: 0.781 ± 0.017	1.917GlnGly: 1.917 ± 0.027	0.712GlnHis: 0.712 ± 0.015	1.288GlnIle: 1.288 ± 0.02	0.578GlnLys: 0.578 ± 0.017	3.266GlnLeu: 3.266 ± 0.036	0.508GlnMet: 0.508 ± 0.014	0.581GlnAsn: 0.581 ± 0.015	1.838GlnPro: 1.838 ± 0.031	1.3GlnGln: 1.3 ± 0.023	2.541GlnArg: 2.541 ± 0.031	1.309GlnSer: 1.309 ± 0.02	1.474GlnThr: 1.474 ± 0.024	2.771GlnVal: 2.771 ± 0.03	0.498GlnTrp: 0.498 ± 0.014	0.577GlnTyr: 0.577 ± 0.017	0.0GlnXaa: 0.0 ± 0.0
Arg	9.487ArgAla: 9.487 ± 0.069	0.518ArgCys: 0.518 ± 0.014	4.524ArgAsp: 4.524 ± 0.04	3.859ArgGlu: 3.859 ± 0.039	2.334ArgPhe: 2.334 ± 0.026	5.295ArgGly: 5.295 ± 0.045	2.031ArgHis: 2.031 ± 0.024	3.304ArgIle: 3.304 ± 0.03	1.412ArgLys: 1.412 ± 0.024	8.874ArgLeu: 8.874 ± 0.072	1.761ArgMet: 1.761 ± 0.025	1.408ArgAsn: 1.408 ± 0.022	4.62ArgPro: 4.62 ± 0.049	2.454ArgGln: 2.454 ± 0.029	7.484ArgArg: 7.484 ± 0.064	4.054ArgSer: 4.054 ± 0.035	4.875ArgThr: 4.875 ± 0.039	5.884ArgVal: 5.884 ± 0.052	1.5ArgTrp: 1.5 ± 0.022	1.882ArgTyr: 1.882 ± 0.024	0.0ArgXaa: 0.0 ± 0.0
Ser	7.023SerAla: 7.023 ± 0.063	0.366SerCys: 0.366 ± 0.012	2.614SerAsp: 2.614 ± 0.032	2.044SerGlu: 2.044 ± 0.026	1.521SerPhe: 1.521 ± 0.022	5.879SerGly: 5.879 ± 0.056	0.925SerHis: 0.925 ± 0.019	1.744SerIle: 1.744 ± 0.026	0.879SerLys: 0.879 ± 0.018	4.615SerLeu: 4.615 ± 0.04	1.082SerMet: 1.082 ± 0.017	0.898SerAsn: 0.898 ± 0.021	3.226SerPro: 3.226 ± 0.046	1.193SerGln: 1.193 ± 0.019	3.694SerArg: 3.694 ± 0.029	2.972SerSer: 2.972 ± 0.04	3.349SerThr: 3.349 ± 0.042	4.148SerVal: 4.148 ± 0.036	1.02SerTrp: 1.02 ± 0.021	1.225SerTyr: 1.225 ± 0.019	0.0SerXaa: 0.0 ± 0.0
Thr	9.56ThrAla: 9.56 ± 0.076	0.451ThrCys: 0.451 ± 0.013	3.729ThrAsp: 3.729 ± 0.037	2.996ThrGlu: 2.996 ± 0.03	1.904ThrPhe: 1.904 ± 0.024	7.329ThrGly: 7.329 ± 0.062	1.102ThrHis: 1.102 ± 0.017	2.279ThrIle: 2.279 ± 0.03	1.185ThrLys: 1.185 ± 0.024	6.202ThrLeu: 6.202 ± 0.047	1.075ThrMet: 1.075 ± 0.017	1.176ThrAsn: 1.176 ± 0.024	4.174ThrPro: 4.174 ± 0.04	1.347ThrGln: 1.347 ± 0.019	3.941ThrArg: 3.941 ± 0.035	3.377ThrSer: 3.377 ± 0.04	4.514ThrThr: 4.514 ± 0.053	6.82ThrVal: 6.82 ± 0.061	1.044ThrTrp: 1.044 ± 0.021	1.391ThrTyr: 1.391 ± 0.027	0.0ThrXaa: 0.0 ± 0.0
Val	12.006ValAla: 12.006 ± 0.07	0.632ValCys: 0.632 ± 0.015	5.099ValAsp: 5.099 ± 0.037	4.248ValGlu: 4.248 ± 0.042	2.392ValPhe: 2.392 ± 0.03	6.376ValGly: 6.376 ± 0.054	1.831ValHis: 1.831 ± 0.026	3.376ValIle: 3.376 ± 0.041	1.568ValLys: 1.568 ± 0.027	9.914ValLeu: 9.914 ± 0.069	1.296ValMet: 1.296 ± 0.022	1.805ValAsn: 1.805 ± 0.026	5.181ValPro: 5.181 ± 0.043	2.171ValGln: 2.171 ± 0.024	6.63ValArg: 6.63 ± 0.059	4.458ValSer: 4.458 ± 0.038	6.732ValThr: 6.732 ± 0.058	8.129ValVal: 8.129 ± 0.053	1.126ValTrp: 1.126 ± 0.019	1.518ValTyr: 1.518 ± 0.024	0.0ValXaa: 0.0 ± 0.0
Trp	1.783TrpAla: 1.783 ± 0.027	0.134TrpCys: 0.134 ± 0.007	0.824TrpAsp: 0.824 ± 0.016	0.622TrpGlu: 0.622 ± 0.014	0.519TrpPhe: 0.519 ± 0.014	0.971TrpGly: 0.971 ± 0.019	0.414TrpHis: 0.414 ± 0.011	0.594TrpIle: 0.594 ± 0.013	0.315TrpLys: 0.315 ± 0.009	1.945TrpLeu: 1.945 ± 0.031	0.292TrpMet: 0.292 ± 0.011	0.436TrpAsn: 0.436 ± 0.012	0.912TrpPro: 0.912 ± 0.02	0.708TrpGln: 0.708 ± 0.016	1.421TrpArg: 1.421 ± 0.025	1.065TrpSer: 1.065 ± 0.02	1.146TrpThr: 1.146 ± 0.018	1.056TrpVal: 1.056 ± 0.021	0.389TrpTrp: 0.389 ± 0.014	0.366TrpTyr: 0.366 ± 0.011	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.771TyrAla: 2.771 ± 0.031	0.156TyrCys: 0.156 ± 0.007	1.395TyrAsp: 1.395 ± 0.029	0.964TyrGlu: 0.964 ± 0.016	0.642TyrPhe: 0.642 ± 0.014	2.006TyrGly: 2.006 ± 0.027	0.443TyrHis: 0.443 ± 0.012	0.413TyrIle: 0.413 ± 0.012	0.335TyrLys: 0.335 ± 0.01	2.4TyrLeu: 2.4 ± 0.032	0.201TyrMet: 0.201 ± 0.008	0.405TyrAsn: 0.405 ± 0.013	1.18TyrPro: 1.18 ± 0.025	0.809TyrGln: 0.809 ± 0.017	1.852TyrArg: 1.852 ± 0.022	0.955TyrSer: 0.955 ± 0.019	1.299TyrThr: 1.299 ± 0.023	1.627TyrVal: 1.627 ± 0.023	0.376TyrTrp: 0.376 ± 0.012	0.486TyrTyr: 0.486 ± 0.016	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 9641 proteins (3188279 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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