Amino acid dipepetide frequency for Maribacter cobaltidurans

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
3.947AlaAla: 3.947 ± 0.079
0.508AlaCys: 0.508 ± 0.022
3.415AlaAsp: 3.415 ± 0.059
3.987AlaGlu: 3.987 ± 0.057
3.212AlaPhe: 3.212 ± 0.052
4.046AlaGly: 4.046 ± 0.068
1.111AlaHis: 1.111 ± 0.026
5.17AlaIle: 5.17 ± 0.074
4.449AlaLys: 4.449 ± 0.07
6.376AlaLeu: 6.376 ± 0.081
1.661AlaMet: 1.661 ± 0.036
3.228AlaAsn: 3.228 ± 0.054
2.023AlaPro: 2.023 ± 0.044
2.409AlaGln: 2.409 ± 0.042
2.03AlaArg: 2.03 ± 0.041
4.079AlaSer: 4.079 ± 0.068
3.528AlaThr: 3.528 ± 0.074
3.79AlaVal: 3.79 ± 0.063
0.701AlaTrp: 0.701 ± 0.025
2.431AlaTyr: 2.431 ± 0.044
0.0AlaXaa: 0.0 ± 0.0
Cys
0.44CysAla: 0.44 ± 0.019
0.115CysCys: 0.115 ± 0.01
0.37CysAsp: 0.37 ± 0.017
0.427CysGlu: 0.427 ± 0.022
0.385CysPhe: 0.385 ± 0.017
0.598CysGly: 0.598 ± 0.024
0.191CysHis: 0.191 ± 0.012
0.524CysIle: 0.524 ± 0.02
0.439CysLys: 0.439 ± 0.016
0.626CysLeu: 0.626 ± 0.025
0.138CysMet: 0.138 ± 0.01
0.365CysAsn: 0.365 ± 0.018
0.32CysPro: 0.32 ± 0.018
0.204CysGln: 0.204 ± 0.013
0.214CysArg: 0.214 ± 0.012
0.524CysSer: 0.524 ± 0.025
0.429CysThr: 0.429 ± 0.02
0.367CysVal: 0.367 ± 0.016
0.072CysTrp: 0.072 ± 0.009
0.296CysTyr: 0.296 ± 0.014
0.0CysXaa: 0.0 ± 0.0
Asp
3.609AspAla: 3.609 ± 0.066
0.387AspCys: 0.387 ± 0.018
3.088AspAsp: 3.088 ± 0.067
3.782AspGlu: 3.782 ± 0.048
3.75AspPhe: 3.75 ± 0.056
4.355AspGly: 4.355 ± 0.113
0.929AspHis: 0.929 ± 0.03
4.558AspIle: 4.558 ± 0.058
3.848AspLys: 3.848 ± 0.063
5.319AspLeu: 5.319 ± 0.073
1.291AspMet: 1.291 ± 0.03
3.121AspAsn: 3.121 ± 0.067
1.908AspPro: 1.908 ± 0.039
1.686AspGln: 1.686 ± 0.042
2.131AspArg: 2.131 ± 0.044
3.506AspSer: 3.506 ± 0.062
3.007AspThr: 3.007 ± 0.072
3.634AspVal: 3.634 ± 0.059
0.832AspTrp: 0.832 ± 0.027
2.835AspTyr: 2.835 ± 0.053
0.0AspXaa: 0.0 ± 0.0
Glu
4.257GluAla: 4.257 ± 0.068
0.32GluCys: 0.32 ± 0.016
3.757GluAsp: 3.757 ± 0.057
5.375GluGlu: 5.375 ± 0.092
2.89GluPhe: 2.89 ± 0.05
4.232GluGly: 4.232 ± 0.068
1.32GluHis: 1.32 ± 0.032
5.499GluIle: 5.499 ± 0.066
6.084GluLys: 6.084 ± 0.09
6.501GluLeu: 6.501 ± 0.074
1.728GluMet: 1.728 ± 0.04
4.766GluAsn: 4.766 ± 0.059
1.928GluPro: 1.928 ± 0.039
2.293GluGln: 2.293 ± 0.044
2.905GluArg: 2.905 ± 0.051
3.577GluSer: 3.577 ± 0.056
3.672GluThr: 3.672 ± 0.049
4.544GluVal: 4.544 ± 0.067
0.701GluTrp: 0.701 ± 0.024
2.534GluTyr: 2.534 ± 0.049
0.0GluXaa: 0.0 ± 0.0
Phe
2.88PheAla: 2.88 ± 0.052
0.391PheCys: 0.391 ± 0.019
3.249PheAsp: 3.249 ± 0.054
3.423PheGlu: 3.423 ± 0.058
2.793PhePhe: 2.793 ± 0.057
3.787PheGly: 3.787 ± 0.063
0.86PheHis: 0.86 ± 0.024
3.558PheIle: 3.558 ± 0.058
3.565PheLys: 3.565 ± 0.06
5.041PheLeu: 5.041 ± 0.078
1.228PheMet: 1.228 ± 0.032
3.003PheAsn: 3.003 ± 0.055
1.811PhePro: 1.811 ± 0.041
1.643PheGln: 1.643 ± 0.039
1.817PheArg: 1.817 ± 0.033
3.839PheSer: 3.839 ± 0.062
2.906PheThr: 2.906 ± 0.056
3.031PheVal: 3.031 ± 0.045
0.584PheTrp: 0.584 ± 0.022
2.157PheTyr: 2.157 ± 0.04
0.0PheXaa: 0.0 ± 0.0
Gly
4.258GlyAla: 4.258 ± 0.076
0.599GlyCys: 0.599 ± 0.032
3.711GlyAsp: 3.711 ± 0.065
4.035GlyGlu: 4.035 ± 0.061
3.742GlyPhe: 3.742 ± 0.057
4.831GlyGly: 4.831 ± 0.085
1.36GlyHis: 1.36 ± 0.033
5.688GlyIle: 5.688 ± 0.069
5.087GlyLys: 5.087 ± 0.074
6.399GlyLeu: 6.399 ± 0.079
1.819GlyMet: 1.819 ± 0.045
3.983GlyAsn: 3.983 ± 0.078
1.655GlyPro: 1.655 ± 0.044
2.124GlyGln: 2.124 ± 0.037
2.364GlyArg: 2.364 ± 0.049
4.209GlySer: 4.209 ± 0.072
4.286GlyThr: 4.286 ± 0.107
4.447GlyVal: 4.447 ± 0.066
0.841GlyTrp: 0.841 ± 0.027
2.917GlyTyr: 2.917 ± 0.046
0.0GlyXaa: 0.0 ± 0.0
His
0.947HisAla: 0.947 ± 0.026
0.188HisCys: 0.188 ± 0.012
0.807HisAsp: 0.807 ± 0.026
1.007HisGlu: 1.007 ± 0.026
1.136HisPhe: 1.136 ± 0.032
1.169HisGly: 1.169 ± 0.035
0.486HisHis: 0.486 ± 0.022
1.398HisIle: 1.398 ± 0.034
1.152HisLys: 1.152 ± 0.032
1.852HisLeu: 1.852 ± 0.039
0.391HisMet: 0.391 ± 0.017
0.845HisAsn: 0.845 ± 0.025
0.944HisPro: 0.944 ± 0.03
0.695HisGln: 0.695 ± 0.019
0.747HisArg: 0.747 ± 0.024
1.099HisSer: 1.099 ± 0.03
0.964HisThr: 0.964 ± 0.028
1.023HisVal: 1.023 ± 0.03
0.258HisTrp: 0.258 ± 0.015
0.782HisTyr: 0.782 ± 0.022
0.0HisXaa: 0.0 ± 0.0
Ile
5.258IleAla: 5.258 ± 0.079
0.591IleCys: 0.591 ± 0.02
4.474IleAsp: 4.474 ± 0.064
4.847IleGlu: 4.847 ± 0.061
3.467IlePhe: 3.467 ± 0.063
5.242IleGly: 5.242 ± 0.068
1.327IleHis: 1.327 ± 0.035
5.197IleIle: 5.197 ± 0.083
5.228IleLys: 5.228 ± 0.073
7.088IleLeu: 7.088 ± 0.087
1.472IleMet: 1.472 ± 0.039
4.157IleAsn: 4.157 ± 0.055
3.274IlePro: 3.274 ± 0.047
2.418IleGln: 2.418 ± 0.05
2.783IleArg: 2.783 ± 0.045
5.47IleSer: 5.47 ± 0.069
4.474IleThr: 4.474 ± 0.083
4.512IleVal: 4.512 ± 0.061
0.728IleTrp: 0.728 ± 0.025
2.725IleTyr: 2.725 ± 0.055
0.0IleXaa: 0.0 ± 0.0
Lys
4.589LysAla: 4.589 ± 0.061
0.309LysCys: 0.309 ± 0.018
4.37LysAsp: 4.37 ± 0.065
6.288LysGlu: 6.288 ± 0.087
2.73LysPhe: 2.73 ± 0.051
4.615LysGly: 4.615 ± 0.067
1.245LysHis: 1.245 ± 0.034
5.547LysIle: 5.547 ± 0.081
6.59LysLys: 6.59 ± 0.1
6.241LysLeu: 6.241 ± 0.076
2.01LysMet: 2.01 ± 0.042
4.767LysAsn: 4.767 ± 0.066
2.334LysPro: 2.334 ± 0.046
2.37LysGln: 2.37 ± 0.043
3.056LysArg: 3.056 ± 0.052
4.588LysSer: 4.588 ± 0.071
4.19LysThr: 4.19 ± 0.059
4.656LysVal: 4.656 ± 0.069
0.786LysTrp: 0.786 ± 0.026
2.834LysTyr: 2.834 ± 0.055
0.0LysXaa: 0.0 ± 0.0
Leu
6.084LeuAla: 6.084 ± 0.08
0.663LeuCys: 0.663 ± 0.023
5.639LeuAsp: 5.639 ± 0.057
6.921LeuGlu: 6.921 ± 0.081
5.005LeuPhe: 5.005 ± 0.073
6.493LeuGly: 6.493 ± 0.076
1.499LeuHis: 1.499 ± 0.037
6.481LeuIle: 6.481 ± 0.093
7.606LeuLys: 7.606 ± 0.102
9.193LeuLeu: 9.193 ± 0.11
2.25LeuMet: 2.25 ± 0.045
5.582LeuAsn: 5.582 ± 0.071
3.69LeuPro: 3.69 ± 0.057
3.158LeuGln: 3.158 ± 0.053
3.603LeuArg: 3.603 ± 0.052
6.704LeuSer: 6.704 ± 0.09
4.956LeuThr: 4.956 ± 0.063
5.805LeuVal: 5.805 ± 0.08
0.968LeuTrp: 0.968 ± 0.03
3.268LeuTyr: 3.268 ± 0.05
0.0LeuXaa: 0.0 ± 0.0
Met
1.932MetAla: 1.932 ± 0.041
0.131MetCys: 0.131 ± 0.011
1.573MetAsp: 1.573 ± 0.04
1.878MetGlu: 1.878 ± 0.042
0.916MetPhe: 0.916 ± 0.03
1.821MetGly: 1.821 ± 0.043
0.42MetHis: 0.42 ± 0.021
1.455MetIle: 1.455 ± 0.03
2.077MetLys: 2.077 ± 0.04
2.074MetLeu: 2.074 ± 0.041
0.618MetMet: 0.618 ± 0.028
1.267MetAsn: 1.267 ± 0.033
0.906MetPro: 0.906 ± 0.028
0.82MetGln: 0.82 ± 0.023
0.884MetArg: 0.884 ± 0.025
1.351MetSer: 1.351 ± 0.034
1.181MetThr: 1.181 ± 0.028
1.648MetVal: 1.648 ± 0.04
0.176MetTrp: 0.176 ± 0.012
0.705MetTyr: 0.705 ± 0.023
0.0MetXaa: 0.0 ± 0.0
Asn
3.546AsnAla: 3.546 ± 0.057
0.421AsnCys: 0.421 ± 0.024
3.185AsnAsp: 3.185 ± 0.063
3.697AsnGlu: 3.697 ± 0.053
2.872AsnPhe: 2.872 ± 0.061
4.295AsnGly: 4.295 ± 0.078
1.009AsnHis: 1.009 ± 0.029
4.248AsnIle: 4.248 ± 0.054
3.742AsnLys: 3.742 ± 0.065
5.469AsnLeu: 5.469 ± 0.078
1.32AsnMet: 1.32 ± 0.033
3.318AsnAsn: 3.318 ± 0.068
2.837AsnPro: 2.837 ± 0.041
2.156AsnGln: 2.156 ± 0.042
2.35AsnArg: 2.35 ± 0.041
3.625AsnSer: 3.625 ± 0.06
3.423AsnThr: 3.423 ± 0.064
3.347AsnVal: 3.347 ± 0.053
0.777AsnTrp: 0.777 ± 0.026
2.521AsnTyr: 2.521 ± 0.048
0.0AsnXaa: 0.0 ± 0.0
Pro
1.88ProAla: 1.88 ± 0.051
0.198ProCys: 0.198 ± 0.012
2.311ProAsp: 2.311 ± 0.047
3.115ProGlu: 3.115 ± 0.06
1.972ProPhe: 1.972 ± 0.036
2.212ProGly: 2.212 ± 0.045
0.626ProHis: 0.626 ± 0.024
2.765ProIle: 2.765 ± 0.044
2.745ProLys: 2.745 ± 0.053
3.223ProLeu: 3.223 ± 0.051
0.924ProMet: 0.924 ± 0.03
2.365ProAsn: 2.365 ± 0.053
0.939ProPro: 0.939 ± 0.032
1.164ProGln: 1.164 ± 0.031
0.996ProArg: 0.996 ± 0.028
2.274ProSer: 2.274 ± 0.038
1.982ProThr: 1.982 ± 0.045
2.388ProVal: 2.388 ± 0.042
0.435ProTrp: 0.435 ± 0.018
1.482ProTyr: 1.482 ± 0.035
0.0ProXaa: 0.0 ± 0.0
Gln
1.872GlnAla: 1.872 ± 0.04
0.164GlnCys: 0.164 ± 0.012
1.82GlnAsp: 1.82 ± 0.035
2.512GlnGlu: 2.512 ± 0.04
1.634GlnPhe: 1.634 ± 0.033
2.052GlnGly: 2.052 ± 0.041
0.596GlnHis: 0.596 ± 0.021
2.539GlnIle: 2.539 ± 0.048
2.759GlnLys: 2.759 ± 0.054
3.494GlnLeu: 3.494 ± 0.048
0.883GlnMet: 0.883 ± 0.027
2.116GlnAsn: 2.116 ± 0.044
1.104GlnPro: 1.104 ± 0.033
1.284GlnGln: 1.284 ± 0.036
1.416GlnArg: 1.416 ± 0.037
1.89GlnSer: 1.89 ± 0.038
1.752GlnThr: 1.752 ± 0.039
1.975GlnVal: 1.975 ± 0.034
0.431GlnTrp: 0.431 ± 0.017
1.254GlnTyr: 1.254 ± 0.033
0.0GlnXaa: 0.0 ± 0.0
Arg
2.128ArgAla: 2.128 ± 0.041
0.199ArgCys: 0.199 ± 0.012
2.028ArgAsp: 2.028 ± 0.041
2.517ArgGlu: 2.517 ± 0.043
2.062ArgPhe: 2.062 ± 0.041
2.08ArgGly: 2.08 ± 0.041
0.641ArgHis: 0.641 ± 0.022
3.047ArgIle: 3.047 ± 0.05
3.028ArgLys: 3.028 ± 0.054
3.671ArgLeu: 3.671 ± 0.062
0.985ArgMet: 0.985 ± 0.031
2.305ArgAsn: 2.305 ± 0.045
1.326ArgPro: 1.326 ± 0.032
1.23ArgGln: 1.23 ± 0.033
1.528ArgArg: 1.528 ± 0.037
2.075ArgSer: 2.075 ± 0.043
2.096ArgThr: 2.096 ± 0.041
2.176ArgVal: 2.176 ± 0.041
0.428ArgTrp: 0.428 ± 0.017
1.634ArgTyr: 1.634 ± 0.037
0.0ArgXaa: 0.0 ± 0.0
Ser
3.711SerAla: 3.711 ± 0.066
0.603SerCys: 0.603 ± 0.024
3.52SerAsp: 3.52 ± 0.059
4.186SerGlu: 4.186 ± 0.053
3.731SerPhe: 3.731 ± 0.056
4.817SerGly: 4.817 ± 0.079
1.126SerHis: 1.126 ± 0.028
5.026SerIle: 5.026 ± 0.065
4.741SerLys: 4.741 ± 0.06
6.334SerLeu: 6.334 ± 0.078
1.461SerMet: 1.461 ± 0.032
3.649SerAsn: 3.649 ± 0.057
2.207SerPro: 2.207 ± 0.042
2.159SerGln: 2.159 ± 0.043
2.193SerArg: 2.193 ± 0.045
4.173SerSer: 4.173 ± 0.062
3.374SerThr: 3.374 ± 0.057
3.924SerVal: 3.924 ± 0.053
0.726SerTrp: 0.726 ± 0.027
2.639SerTyr: 2.639 ± 0.048
0.0SerXaa: 0.0 ± 0.0
Thr
3.571ThrAla: 3.571 ± 0.064
0.361ThrCys: 0.361 ± 0.021
3.426ThrAsp: 3.426 ± 0.077
3.601ThrGlu: 3.601 ± 0.06
2.963ThrPhe: 2.963 ± 0.056
4.102ThrGly: 4.102 ± 0.083
0.945ThrHis: 0.945 ± 0.025
4.35ThrIle: 4.35 ± 0.068
3.482ThrLys: 3.482 ± 0.055
5.388ThrLeu: 5.388 ± 0.075
1.109ThrMet: 1.109 ± 0.024
2.989ThrAsn: 2.989 ± 0.065
2.468ThrPro: 2.468 ± 0.05
1.797ThrGln: 1.797 ± 0.037
1.7ThrArg: 1.7 ± 0.036
3.594ThrSer: 3.594 ± 0.063
3.223ThrThr: 3.223 ± 0.073
3.728ThrVal: 3.728 ± 0.073
0.631ThrTrp: 0.631 ± 0.027
2.373ThrTyr: 2.373 ± 0.046
0.0ThrXaa: 0.0 ± 0.0
Val
4.117ValAla: 4.117 ± 0.062
0.491ValCys: 0.491 ± 0.018
3.666ValAsp: 3.666 ± 0.059
4.01ValGlu: 4.01 ± 0.056
3.3ValPhe: 3.3 ± 0.059
4.003ValGly: 4.003 ± 0.068
1.136ValHis: 1.136 ± 0.028
4.389ValIle: 4.389 ± 0.059
4.032ValLys: 4.032 ± 0.062
6.326ValLeu: 6.326 ± 0.067
1.443ValMet: 1.443 ± 0.034
3.37ValAsn: 3.37 ± 0.056
2.445ValPro: 2.445 ± 0.047
1.956ValGln: 1.956 ± 0.037
2.236ValArg: 2.236 ± 0.043
4.492ValSer: 4.492 ± 0.055
3.516ValThr: 3.516 ± 0.072
4.236ValVal: 4.236 ± 0.06
0.677ValTrp: 0.677 ± 0.026
2.284ValTyr: 2.284 ± 0.037
0.0ValXaa: 0.0 ± 0.0
Trp
0.635TrpAla: 0.635 ± 0.021
0.09TrpCys: 0.09 ± 0.009
0.7TrpAsp: 0.7 ± 0.029
0.793TrpGlu: 0.793 ± 0.026
0.585TrpPhe: 0.585 ± 0.022
0.781TrpGly: 0.781 ± 0.026
0.247TrpHis: 0.247 ± 0.014
0.786TrpIle: 0.786 ± 0.027
0.847TrpLys: 0.847 ± 0.026
1.039TrpLeu: 1.039 ± 0.029
0.344TrpMet: 0.344 ± 0.015
0.726TrpAsn: 0.726 ± 0.024
0.326TrpPro: 0.326 ± 0.018
0.462TrpGln: 0.462 ± 0.021
0.466TrpArg: 0.466 ± 0.02
0.691TrpSer: 0.691 ± 0.025
0.589TrpThr: 0.589 ± 0.025
0.679TrpVal: 0.679 ± 0.022
0.18TrpTrp: 0.18 ± 0.012
0.439TrpTyr: 0.439 ± 0.019
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.44TyrAla: 2.44 ± 0.041
0.315TyrCys: 0.315 ± 0.014
2.468TyrAsp: 2.468 ± 0.049
2.481TyrGlu: 2.481 ± 0.049
2.422TyrPhe: 2.422 ± 0.044
2.826TyrGly: 2.826 ± 0.054
0.812TyrHis: 0.812 ± 0.024
2.507TyrIle: 2.507 ± 0.043
2.615TyrLys: 2.615 ± 0.048
3.917TyrLeu: 3.917 ± 0.06
0.759TyrMet: 0.759 ± 0.021
2.235TyrAsn: 2.235 ± 0.046
1.552TyrPro: 1.552 ± 0.031
1.516TyrGln: 1.516 ± 0.038
1.766TyrArg: 1.766 ± 0.035
2.539TyrSer: 2.539 ± 0.048
2.253TyrThr: 2.253 ± 0.045
2.215TyrVal: 2.215 ± 0.037
0.47TyrTrp: 0.47 ± 0.016
1.72TyrTyr: 1.72 ± 0.035
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 4004 proteins (1370011 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski