Amino acid dipepetide frequency for Leekyejoonella antrihumi

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	17.777AlaAla: 17.777 ± 0.151	1.082AlaCys: 1.082 ± 0.027	7.633AlaAsp: 7.633 ± 0.077	6.34AlaGlu: 6.34 ± 0.08	3.306AlaPhe: 3.306 ± 0.057	11.754AlaGly: 11.754 ± 0.097	2.944AlaHis: 2.944 ± 0.046	4.992AlaIle: 4.992 ± 0.062	2.869AlaLys: 2.869 ± 0.061	12.844AlaLeu: 12.844 ± 0.107	2.896AlaMet: 2.896 ± 0.045	2.227AlaAsn: 2.227 ± 0.044	5.702AlaPro: 5.702 ± 0.071	4.39AlaGln: 4.39 ± 0.054	9.052AlaArg: 9.052 ± 0.083	6.491AlaSer: 6.491 ± 0.071	7.5AlaThr: 7.5 ± 0.075	10.736AlaVal: 10.736 ± 0.097	1.722AlaTrp: 1.722 ± 0.039	2.664AlaTyr: 2.664 ± 0.043	0.0AlaXaa: 0.0 ± 0.0
Cys	1.101CysAla: 1.101 ± 0.027	0.138CysCys: 0.138 ± 0.01	0.557CysAsp: 0.557 ± 0.019	0.426CysGlu: 0.426 ± 0.019	0.255CysPhe: 0.255 ± 0.012	1.007CysGly: 1.007 ± 0.025	0.229CysHis: 0.229 ± 0.013	0.293CysIle: 0.293 ± 0.012	0.135CysLys: 0.135 ± 0.011	0.747CysLeu: 0.747 ± 0.022	0.153CysMet: 0.153 ± 0.011	0.166CysAsn: 0.166 ± 0.01	0.515CysPro: 0.515 ± 0.021	0.231CysGln: 0.231 ± 0.013	0.648CysArg: 0.648 ± 0.019	0.534CysSer: 0.534 ± 0.022	0.568CysThr: 0.568 ± 0.021	0.704CysVal: 0.704 ± 0.023	0.158CysTrp: 0.158 ± 0.011	0.191CysTyr: 0.191 ± 0.012	0.0CysXaa: 0.0 ± 0.0
Asp	7.277AspAla: 7.277 ± 0.079	0.413AspCys: 0.413 ± 0.02	3.944AspAsp: 3.944 ± 0.062	3.888AspGlu: 3.888 ± 0.054	1.545AspPhe: 1.545 ± 0.036	5.789AspGly: 5.789 ± 0.071	1.602AspHis: 1.602 ± 0.031	2.15AspIle: 2.15 ± 0.043	1.164AspLys: 1.164 ± 0.028	6.983AspLeu: 6.983 ± 0.081	0.917AspMet: 0.917 ± 0.024	1.074AspAsn: 1.074 ± 0.03	4.182AspPro: 4.182 ± 0.052	2.097AspGln: 2.097 ± 0.035	4.778AspArg: 4.778 ± 0.065	2.667AspSer: 2.667 ± 0.041	2.986AspThr: 2.986 ± 0.044	5.174AspVal: 5.174 ± 0.072	1.008AspTrp: 1.008 ± 0.03	1.218AspTyr: 1.218 ± 0.03	0.0AspXaa: 0.0 ± 0.0
Glu	5.766GluAla: 5.766 ± 0.066	0.41GluCys: 0.41 ± 0.017	2.513GluAsp: 2.513 ± 0.049	2.429GluGlu: 2.429 ± 0.057	1.402GluPhe: 1.402 ± 0.032	3.463GluGly: 3.463 ± 0.052	1.769GluHis: 1.769 ± 0.032	2.319GluIle: 2.319 ± 0.038	1.075GluLys: 1.075 ± 0.03	5.877GluLeu: 5.877 ± 0.077	1.004GluMet: 1.004 ± 0.026	0.826GluAsn: 0.826 ± 0.026	2.756GluPro: 2.756 ± 0.046	2.333GluGln: 2.333 ± 0.046	4.565GluArg: 4.565 ± 0.073	2.727GluSer: 2.727 ± 0.045	2.562GluThr: 2.562 ± 0.042	4.507GluVal: 4.507 ± 0.065	0.707GluTrp: 0.707 ± 0.023	0.909GluTyr: 0.909 ± 0.026	0.0GluXaa: 0.0 ± 0.0
Phe	3.637PheAla: 3.637 ± 0.059	0.297PheCys: 0.297 ± 0.015	2.021PheAsp: 2.021 ± 0.035	1.435PheGlu: 1.435 ± 0.03	0.925PhePhe: 0.925 ± 0.028	3.169PheGly: 3.169 ± 0.05	0.69PheHis: 0.69 ± 0.022	1.1PheIle: 1.1 ± 0.029	0.532PheLys: 0.532 ± 0.022	2.413PheLeu: 2.413 ± 0.042	0.447PheMet: 0.447 ± 0.018	0.674PheAsn: 0.674 ± 0.024	1.335PhePro: 1.335 ± 0.031	0.731PheGln: 0.731 ± 0.023	1.576PheArg: 1.576 ± 0.037	1.615PheSer: 1.615 ± 0.035	1.911PheThr: 1.911 ± 0.041	2.414PheVal: 2.414 ± 0.045	0.442PheTrp: 0.442 ± 0.019	0.657PheTyr: 0.657 ± 0.022	0.0PheXaa: 0.0 ± 0.0
Gly	10.058GlyAla: 10.058 ± 0.093	0.944GlyCys: 0.944 ± 0.023	4.946GlyAsp: 4.946 ± 0.054	4.27GlyGlu: 4.27 ± 0.06	2.966GlyPhe: 2.966 ± 0.047	7.97GlyGly: 7.97 ± 0.099	2.336GlyHis: 2.336 ± 0.04	4.038GlyIle: 4.038 ± 0.052	2.316GlyLys: 2.316 ± 0.044	9.137GlyLeu: 9.137 ± 0.086	2.195GlyMet: 2.195 ± 0.039	1.843GlyAsn: 1.843 ± 0.037	4.291GlyPro: 4.291 ± 0.055	3.158GlyGln: 3.158 ± 0.047	6.888GlyArg: 6.888 ± 0.07	5.863GlySer: 5.863 ± 0.07	5.481GlyThr: 5.481 ± 0.063	7.664GlyVal: 7.664 ± 0.076	1.737GlyTrp: 1.737 ± 0.035	2.371GlyTyr: 2.371 ± 0.042	0.0GlyXaa: 0.0 ± 0.0
His	2.83HisAla: 2.83 ± 0.043	0.23HisCys: 0.23 ± 0.014	1.672HisAsp: 1.672 ± 0.036	1.357HisGlu: 1.357 ± 0.032	0.656HisPhe: 0.656 ± 0.021	2.505HisGly: 2.505 ± 0.036	0.797HisHis: 0.797 ± 0.025	0.794HisIle: 0.794 ± 0.021	0.397HisLys: 0.397 ± 0.015	2.774HisLeu: 2.774 ± 0.043	0.373HisMet: 0.373 ± 0.017	0.471HisAsn: 0.471 ± 0.017	1.807HisPro: 1.807 ± 0.035	0.848HisGln: 0.848 ± 0.023	2.137HisArg: 2.137 ± 0.038	1.253HisSer: 1.253 ± 0.026	1.468HisThr: 1.468 ± 0.034	1.968HisVal: 1.968 ± 0.042	0.396HisTrp: 0.396 ± 0.018	0.496HisTyr: 0.496 ± 0.016	0.0HisXaa: 0.0 ± 0.0
Ile	5.66IleAla: 5.66 ± 0.066	0.422IleCys: 0.422 ± 0.016	3.059IleAsp: 3.059 ± 0.051	2.501IleGlu: 2.501 ± 0.045	1.094IlePhe: 1.094 ± 0.031	4.489IleGly: 4.489 ± 0.06	0.855IleHis: 0.855 ± 0.025	1.567IleIle: 1.567 ± 0.04	0.822IleLys: 0.822 ± 0.025	3.102IleLeu: 3.102 ± 0.052	0.651IleMet: 0.651 ± 0.022	0.965IleAsn: 0.965 ± 0.023	2.104IlePro: 2.104 ± 0.038	0.993IleGln: 0.993 ± 0.025	2.632IleArg: 2.632 ± 0.044	2.323IleSer: 2.323 ± 0.038	2.753IleThr: 2.753 ± 0.047	3.706IleVal: 3.706 ± 0.057	0.499IleTrp: 0.499 ± 0.018	0.814IleTyr: 0.814 ± 0.024	0.0IleXaa: 0.0 ± 0.0
Lys	2.677LysAla: 2.677 ± 0.049	0.113LysCys: 0.113 ± 0.01	1.276LysAsp: 1.276 ± 0.034	0.98LysGlu: 0.98 ± 0.027	0.568LysPhe: 0.568 ± 0.02	1.692LysGly: 1.692 ± 0.039	0.523LysHis: 0.523 ± 0.019	0.946LysIle: 0.946 ± 0.023	0.775LysLys: 0.775 ± 0.03	1.713LysLeu: 1.713 ± 0.036	0.462LysMet: 0.462 ± 0.017	0.513LysAsn: 0.513 ± 0.017	1.253LysPro: 1.253 ± 0.033	0.814LysGln: 0.814 ± 0.024	1.43LysArg: 1.43 ± 0.034	1.332LysSer: 1.332 ± 0.034	1.365LysThr: 1.365 ± 0.031	2.071LysVal: 2.071 ± 0.036	0.267LysTrp: 0.267 ± 0.013	0.473LysTyr: 0.473 ± 0.02	0.0LysXaa: 0.0 ± 0.0
Leu	13.809LeuAla: 13.809 ± 0.125	0.832LeuCys: 0.832 ± 0.023	6.518LeuAsp: 6.518 ± 0.073	4.78LeuGlu: 4.78 ± 0.07	2.512LeuPhe: 2.512 ± 0.048	8.922LeuGly: 8.922 ± 0.086	2.399LeuHis: 2.399 ± 0.039	4.095LeuIle: 4.095 ± 0.062	1.885LeuLys: 1.885 ± 0.036	10.132LeuLeu: 10.132 ± 0.108	1.813LeuMet: 1.813 ± 0.039	1.817LeuAsn: 1.817 ± 0.035	5.713LeuPro: 5.713 ± 0.063	2.961LeuGln: 2.961 ± 0.046	7.869LeuArg: 7.869 ± 0.073	5.811LeuSer: 5.811 ± 0.059	6.626LeuThr: 6.626 ± 0.066	9.201LeuVal: 9.201 ± 0.101	1.232LeuTrp: 1.232 ± 0.03	1.598LeuTyr: 1.598 ± 0.036	0.0LeuXaa: 0.0 ± 0.0
Met	2.374MetAla: 2.374 ± 0.039	0.185MetCys: 0.185 ± 0.012	0.959MetAsp: 0.959 ± 0.027	0.771MetGlu: 0.771 ± 0.022	0.543MetPhe: 0.543 ± 0.02	1.486MetGly: 1.486 ± 0.032	0.472MetHis: 0.472 ± 0.018	0.896MetIle: 0.896 ± 0.023	0.492MetLys: 0.492 ± 0.019	2.07MetLeu: 2.07 ± 0.037	0.415MetMet: 0.415 ± 0.019	0.514MetAsn: 0.514 ± 0.019	1.28MetPro: 1.28 ± 0.029	0.65MetGln: 0.65 ± 0.02	1.619MetArg: 1.619 ± 0.036	1.798MetSer: 1.798 ± 0.039	1.851MetThr: 1.851 ± 0.038	1.676MetVal: 1.676 ± 0.034	0.258MetTrp: 0.258 ± 0.013	0.333MetTyr: 0.333 ± 0.015	0.0MetXaa: 0.0 ± 0.0
Asn	2.419AsnAla: 2.419 ± 0.041	0.168AsnCys: 0.168 ± 0.012	1.109AsnAsp: 1.109 ± 0.031	0.879AsnGlu: 0.879 ± 0.027	0.535AsnPhe: 0.535 ± 0.021	1.892AsnGly: 1.892 ± 0.04	0.488AsnHis: 0.488 ± 0.017	0.781AsnIle: 0.781 ± 0.023	0.416AsnLys: 0.416 ± 0.02	2.027AsnLeu: 2.027 ± 0.043	0.32AsnMet: 0.32 ± 0.016	0.492AsnAsn: 0.492 ± 0.018	1.588AsnPro: 1.588 ± 0.036	0.638AsnGln: 0.638 ± 0.019	1.305AsnArg: 1.305 ± 0.033	1.019AsnSer: 1.019 ± 0.025	1.183AsnThr: 1.183 ± 0.032	1.615AsnVal: 1.615 ± 0.034	0.299AsnTrp: 0.299 ± 0.015	0.492AsnTyr: 0.492 ± 0.019	0.0AsnXaa: 0.0 ± 0.0
Pro	6.778ProAla: 6.778 ± 0.068	0.327ProCys: 0.327 ± 0.014	3.947ProAsp: 3.947 ± 0.058	3.2ProGlu: 3.2 ± 0.045	1.477ProPhe: 1.477 ± 0.03	5.526ProGly: 5.526 ± 0.057	1.365ProHis: 1.365 ± 0.029	1.984ProIle: 1.984 ± 0.036	1.185ProLys: 1.185 ± 0.032	4.71ProLeu: 4.71 ± 0.059	1.234ProMet: 1.234 ± 0.029	1.049ProAsn: 1.049 ± 0.028	2.797ProPro: 2.797 ± 0.058	1.92ProGln: 1.92 ± 0.043	3.53ProArg: 3.53 ± 0.051	3.461ProSer: 3.461 ± 0.049	3.726ProThr: 3.726 ± 0.057	4.911ProVal: 4.911 ± 0.055	0.867ProTrp: 0.867 ± 0.021	1.153ProTyr: 1.153 ± 0.032	0.0ProXaa: 0.0 ± 0.0
Gln	4.164GlnAla: 4.164 ± 0.064	0.257GlnCys: 0.257 ± 0.013	1.689GlnAsp: 1.689 ± 0.032	1.581GlnGlu: 1.581 ± 0.033	0.843GlnPhe: 0.843 ± 0.026	2.405GlnGly: 2.405 ± 0.035	1.005GlnHis: 1.005 ± 0.027	1.636GlnIle: 1.636 ± 0.033	0.599GlnLys: 0.599 ± 0.021	3.6GlnLeu: 3.6 ± 0.056	0.719GlnMet: 0.719 ± 0.021	0.604GlnAsn: 0.604 ± 0.021	1.879GlnPro: 1.879 ± 0.04	1.588GlnGln: 1.588 ± 0.032	2.79GlnArg: 2.79 ± 0.043	1.799GlnSer: 1.799 ± 0.04	1.773GlnThr: 1.773 ± 0.037	3.425GlnVal: 3.425 ± 0.048	0.578GlnTrp: 0.578 ± 0.022	0.579GlnTyr: 0.579 ± 0.021	0.0GlnXaa: 0.0 ± 0.0
Arg	8.737ArgAla: 8.737 ± 0.092	0.673ArgCys: 0.673 ± 0.021	4.363ArgAsp: 4.363 ± 0.071	4.01ArgGlu: 4.01 ± 0.055	2.093ArgPhe: 2.093 ± 0.037	5.506ArgGly: 5.506 ± 0.066	2.067ArgHis: 2.067 ± 0.04	3.253ArgIle: 3.253 ± 0.041	1.595ArgLys: 1.595 ± 0.032	7.951ArgLeu: 7.951 ± 0.079	1.858ArgMet: 1.858 ± 0.035	1.318ArgAsn: 1.318 ± 0.031	4.233ArgPro: 4.233 ± 0.062	2.542ArgGln: 2.542 ± 0.042	7.123ArgArg: 7.123 ± 0.086	4.619ArgSer: 4.619 ± 0.054	4.513ArgThr: 4.513 ± 0.054	5.975ArgVal: 5.975 ± 0.069	1.35ArgTrp: 1.35 ± 0.029	1.665ArgTyr: 1.665 ± 0.03	0.0ArgXaa: 0.0 ± 0.0
Ser	7.112SerAla: 7.112 ± 0.084	0.492SerCys: 0.492 ± 0.018	3.256SerAsp: 3.256 ± 0.048	2.412SerGlu: 2.412 ± 0.038	1.795SerPhe: 1.795 ± 0.04	6.031SerGly: 6.031 ± 0.065	1.352SerHis: 1.352 ± 0.034	2.358SerIle: 2.358 ± 0.043	1.258SerLys: 1.258 ± 0.03	5.229SerLeu: 5.229 ± 0.06	1.534SerMet: 1.534 ± 0.031	1.264SerAsn: 1.264 ± 0.028	3.287SerPro: 3.287 ± 0.051	1.743SerGln: 1.743 ± 0.036	4.147SerArg: 4.147 ± 0.058	3.9SerSer: 3.9 ± 0.074	3.991SerThr: 3.991 ± 0.061	4.788SerVal: 4.788 ± 0.059	1.066SerTrp: 1.066 ± 0.028	1.266SerTyr: 1.266 ± 0.028	0.0SerXaa: 0.0 ± 0.0
Thr	7.618ThrAla: 7.618 ± 0.078	0.558ThrCys: 0.558 ± 0.019	3.634ThrAsp: 3.634 ± 0.052	2.649ThrGlu: 2.649 ± 0.045	1.915ThrPhe: 1.915 ± 0.034	6.22ThrGly: 6.22 ± 0.067	1.413ThrHis: 1.413 ± 0.029	2.601ThrIle: 2.601 ± 0.04	1.338ThrLys: 1.338 ± 0.034	5.82ThrLeu: 5.82 ± 0.071	1.282ThrMet: 1.282 ± 0.031	1.251ThrAsn: 1.251 ± 0.033	3.861ThrPro: 3.861 ± 0.051	1.8ThrGln: 1.8 ± 0.033	4.134ThrArg: 4.134 ± 0.058	3.969ThrSer: 3.969 ± 0.065	4.261ThrThr: 4.261 ± 0.068	5.694ThrVal: 5.694 ± 0.065	1.059ThrTrp: 1.059 ± 0.027	1.461ThrTyr: 1.461 ± 0.035	0.0ThrXaa: 0.0 ± 0.0
Val	10.908ValAla: 10.908 ± 0.098	0.818ValCys: 0.818 ± 0.021	5.535ValAsp: 5.535 ± 0.073	4.463ValGlu: 4.463 ± 0.062	2.35ValPhe: 2.35 ± 0.044	7.578ValGly: 7.578 ± 0.081	2.051ValHis: 2.051 ± 0.043	3.922ValIle: 3.922 ± 0.059	1.706ValLys: 1.706 ± 0.038	9.28ValLeu: 9.28 ± 0.093	1.758ValMet: 1.758 ± 0.032	1.769ValAsn: 1.769 ± 0.037	4.649ValPro: 4.649 ± 0.053	2.707ValGln: 2.707 ± 0.042	6.283ValArg: 6.283 ± 0.063	4.954ValSer: 4.954 ± 0.066	5.824ValThr: 5.824 ± 0.068	8.64ValVal: 8.64 ± 0.099	1.105ValTrp: 1.105 ± 0.027	1.445ValTyr: 1.445 ± 0.032	0.0ValXaa: 0.0 ± 0.0
Trp	1.598TrpAla: 1.598 ± 0.038	0.193TrpCys: 0.193 ± 0.011	0.814TrpAsp: 0.814 ± 0.026	0.576TrpGlu: 0.576 ± 0.016	0.55TrpPhe: 0.55 ± 0.023	1.065TrpGly: 1.065 ± 0.026	0.455TrpHis: 0.455 ± 0.018	0.671TrpIle: 0.671 ± 0.02	0.331TrpLys: 0.331 ± 0.016	1.777TrpLeu: 1.777 ± 0.039	0.367TrpMet: 0.367 ± 0.017	0.363TrpAsn: 0.363 ± 0.016	0.799TrpPro: 0.799 ± 0.023	0.65TrpGln: 0.65 ± 0.018	1.301TrpArg: 1.301 ± 0.034	1.092TrpSer: 1.092 ± 0.027	1.012TrpThr: 1.012 ± 0.029	1.175TrpVal: 1.175 ± 0.025	0.399TrpTrp: 0.399 ± 0.021	0.308TrpTyr: 0.308 ± 0.015	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.623TyrAla: 2.623 ± 0.04	0.206TyrCys: 0.206 ± 0.013	1.412TyrAsp: 1.412 ± 0.032	0.972TyrGlu: 0.972 ± 0.023	0.695TyrPhe: 0.695 ± 0.022	2.001TyrGly: 2.001 ± 0.044	0.419TyrHis: 0.419 ± 0.017	0.616TyrIle: 0.616 ± 0.021	0.348TyrLys: 0.348 ± 0.014	2.34TyrLeu: 2.34 ± 0.04	0.244TyrMet: 0.244 ± 0.013	0.464TyrAsn: 0.464 ± 0.018	1.115TyrPro: 1.115 ± 0.029	0.717TyrGln: 0.717 ± 0.022	1.637TyrArg: 1.637 ± 0.032	1.051TyrSer: 1.051 ± 0.031	1.183TyrThr: 1.183 ± 0.027	1.701TyrVal: 1.701 ± 0.036	0.348TyrTrp: 0.348 ± 0.014	0.478TyrTyr: 0.478 ± 0.021	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.0XaaAla: 0.0 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.0XaaGly: 0.0 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.0XaaLeu: 0.0 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.0XaaArg: 0.0 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.0XaaVal: 0.0 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.0XaaXaa: 0.0 ± 0.0

Statistics based on 4772 proteins (1527100 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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