Amino acid dipepetide frequency for Monosporascus sp. CRB-9-2

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10^-3.

For more information see sequence space article on Wikipedia.

	Ala	Cys	Asp	Glu	Phe	Gly	His	Ile	Lys	Leu	Met	Asn	Pro	Gln	Arg	Ser	Thr	Val	Trp	Tyr	Xaa
Ala	10.965AlaAla: 10.965 ± 0.069	1.07AlaCys: 1.07 ± 0.013	4.931AlaAsp: 4.931 ± 0.031	5.876AlaGlu: 5.876 ± 0.041	3.147AlaPhe: 3.147 ± 0.026	6.685AlaGly: 6.685 ± 0.042	1.88AlaHis: 1.88 ± 0.019	4.113AlaIle: 4.113 ± 0.031	4.151AlaLys: 4.151 ± 0.032	8.142AlaLeu: 8.142 ± 0.047	2.068AlaMet: 2.068 ± 0.022	3.051AlaAsn: 3.051 ± 0.024	5.236AlaPro: 5.236 ± 0.052	3.485AlaGln: 3.485 ± 0.03	5.77AlaArg: 5.77 ± 0.039	7.391AlaSer: 7.391 ± 0.042	5.528AlaThr: 5.528 ± 0.035	5.948AlaVal: 5.948 ± 0.034	1.231AlaTrp: 1.231 ± 0.016	2.275AlaTyr: 2.275 ± 0.022	0.0AlaXaa: 0.0 ± 0.0
Cys	0.96CysAla: 0.96 ± 0.014	0.225CysCys: 0.225 ± 0.008	0.662CysAsp: 0.662 ± 0.013	0.603CysGlu: 0.603 ± 0.01	0.498CysPhe: 0.498 ± 0.011	0.957CysGly: 0.957 ± 0.015	0.308CysHis: 0.308 ± 0.008	0.641CysIle: 0.641 ± 0.012	0.46CysLys: 0.46 ± 0.01	1.147CysLeu: 1.147 ± 0.016	0.245CysMet: 0.245 ± 0.007	0.404CysAsn: 0.404 ± 0.01	0.624CysPro: 0.624 ± 0.011	0.414CysGln: 0.414 ± 0.009	0.783CysArg: 0.783 ± 0.013	0.831CysSer: 0.831 ± 0.013	0.615CysThr: 0.615 ± 0.012	0.783CysVal: 0.783 ± 0.015	0.198CysTrp: 0.198 ± 0.006	0.341CysTyr: 0.341 ± 0.008	0.0CysXaa: 0.0 ± 0.0
Asp	5.346AspAla: 5.346 ± 0.032	0.606AspCys: 0.606 ± 0.012	4.636AspAsp: 4.636 ± 0.038	4.703AspGlu: 4.703 ± 0.037	2.2AspPhe: 2.2 ± 0.02	4.626AspGly: 4.626 ± 0.035	1.221AspHis: 1.221 ± 0.015	2.979AspIle: 2.979 ± 0.024	2.336AspLys: 2.336 ± 0.023	5.068AspLeu: 5.068 ± 0.034	1.266AspMet: 1.266 ± 0.016	1.887AspAsn: 1.887 ± 0.02	3.568AspPro: 3.568 ± 0.028	1.819AspGln: 1.819 ± 0.019	3.378AspArg: 3.378 ± 0.031	4.019AspSer: 4.019 ± 0.032	2.89AspThr: 2.89 ± 0.024	3.926AspVal: 3.926 ± 0.024	0.94AspTrp: 0.94 ± 0.014	1.655AspTyr: 1.655 ± 0.018	0.001AspXaa: 0.001 ± 0.0
Glu	6.069GluAla: 6.069 ± 0.038	0.642GluCys: 0.642 ± 0.013	4.42GluAsp: 4.42 ± 0.036	5.571GluGlu: 5.571 ± 0.045	1.969GluPhe: 1.969 ± 0.021	4.095GluGly: 4.095 ± 0.032	1.432GluHis: 1.432 ± 0.017	2.913GluIle: 2.913 ± 0.023	3.578GluLys: 3.578 ± 0.031	5.415GluLeu: 5.415 ± 0.036	1.42GluMet: 1.42 ± 0.018	2.261GluAsn: 2.261 ± 0.022	3.057GluPro: 3.057 ± 0.032	2.466GluGln: 2.466 ± 0.025	4.278GluArg: 4.278 ± 0.034	4.171GluSer: 4.171 ± 0.035	3.515GluThr: 3.515 ± 0.031	3.754GluVal: 3.754 ± 0.029	0.914GluTrp: 0.914 ± 0.013	1.652GluTyr: 1.652 ± 0.018	0.0GluXaa: 0.0 ± 0.0
Phe	3.074PheAla: 3.074 ± 0.026	0.519PheCys: 0.519 ± 0.01	2.248PheAsp: 2.248 ± 0.022	2.193PheGlu: 2.193 ± 0.023	1.471PhePhe: 1.471 ± 0.019	2.856PheGly: 2.856 ± 0.026	0.832PheHis: 0.832 ± 0.013	1.57PheIle: 1.57 ± 0.017	1.431PheLys: 1.431 ± 0.017	3.205PheLeu: 3.205 ± 0.027	0.738PheMet: 0.738 ± 0.013	1.299PheAsn: 1.299 ± 0.015	1.861PhePro: 1.861 ± 0.02	1.283PheGln: 1.283 ± 0.015	2.082PheArg: 2.082 ± 0.019	2.687PheSer: 2.687 ± 0.023	1.996PheThr: 1.996 ± 0.023	2.349PheVal: 2.349 ± 0.023	0.616PheTrp: 0.616 ± 0.011	1.055PheTyr: 1.055 ± 0.014	0.0PheXaa: 0.0 ± 0.0
Gly	6.243GlyAla: 6.243 ± 0.04	0.881GlyCys: 0.881 ± 0.013	4.223GlyAsp: 4.223 ± 0.03	4.008GlyGlu: 4.008 ± 0.032	2.776GlyPhe: 2.776 ± 0.022	6.833GlyGly: 6.833 ± 0.054	1.807GlyHis: 1.807 ± 0.019	3.414GlyIle: 3.414 ± 0.028	3.378GlyLys: 3.378 ± 0.029	6.16GlyLeu: 6.16 ± 0.037	1.569GlyMet: 1.569 ± 0.019	2.668GlyAsn: 2.668 ± 0.025	3.751GlyPro: 3.751 ± 0.04	2.585GlyGln: 2.585 ± 0.022	4.813GlyArg: 4.813 ± 0.036	5.886GlySer: 5.886 ± 0.038	4.126GlyThr: 4.126 ± 0.03	4.584GlyVal: 4.584 ± 0.038	1.19GlyTrp: 1.19 ± 0.015	2.17GlyTyr: 2.17 ± 0.021	0.001GlyXaa: 0.001 ± 0.001
His	1.925HisAla: 1.925 ± 0.017	0.309HisCys: 0.309 ± 0.008	1.309HisAsp: 1.309 ± 0.015	1.353HisGlu: 1.353 ± 0.017	0.882HisPhe: 0.882 ± 0.014	1.818HisGly: 1.818 ± 0.018	0.874HisHis: 0.874 ± 0.017	1.109HisIle: 1.109 ± 0.015	0.85HisLys: 0.85 ± 0.011	2.101HisLeu: 2.101 ± 0.023	0.485HisMet: 0.485 ± 0.01	0.801HisAsn: 0.801 ± 0.011	1.655HisPro: 1.655 ± 0.019	0.978HisGln: 0.978 ± 0.016	1.588HisArg: 1.588 ± 0.02	1.661HisSer: 1.661 ± 0.022	1.151HisThr: 1.151 ± 0.013	1.453HisVal: 1.453 ± 0.016	0.341HisTrp: 0.341 ± 0.008	0.693HisTyr: 0.693 ± 0.011	0.0HisXaa: 0.0 ± 0.0
Ile	4.016IleAla: 4.016 ± 0.027	0.678IleCys: 0.678 ± 0.011	2.735IleAsp: 2.735 ± 0.023	2.743IleGlu: 2.743 ± 0.023	1.754IlePhe: 1.754 ± 0.021	2.972IleGly: 2.972 ± 0.026	1.051IleHis: 1.051 ± 0.013	2.17IleIle: 2.17 ± 0.022	1.948IleLys: 1.948 ± 0.021	4.119IleLeu: 4.119 ± 0.028	0.943IleMet: 0.943 ± 0.013	1.626IleAsn: 1.626 ± 0.018	2.828IlePro: 2.828 ± 0.023	1.706IleGln: 1.706 ± 0.018	2.874IleArg: 2.874 ± 0.023	3.323IleSer: 3.323 ± 0.027	2.597IleThr: 2.597 ± 0.025	2.991IleVal: 2.991 ± 0.023	0.682IleTrp: 0.682 ± 0.011	1.278IleTyr: 1.278 ± 0.016	0.0IleXaa: 0.0 ± 0.0
Lys	4.305LysAla: 4.305 ± 0.035	0.429LysCys: 0.429 ± 0.011	2.665LysAsp: 2.665 ± 0.026	3.22LysGlu: 3.22 ± 0.031	1.364LysPhe: 1.364 ± 0.016	2.982LysGly: 2.982 ± 0.023	1.032LysHis: 1.032 ± 0.014	2.014LysIle: 2.014 ± 0.021	3.108LysLys: 3.108 ± 0.04	3.914LysLeu: 3.914 ± 0.027	0.938LysMet: 0.938 ± 0.012	1.562LysAsn: 1.562 ± 0.017	2.748LysPro: 2.748 ± 0.03	1.755LysGln: 1.755 ± 0.019	3.341LysArg: 3.341 ± 0.029	3.19LysSer: 3.19 ± 0.026	2.67LysThr: 2.67 ± 0.024	2.731LysVal: 2.731 ± 0.025	0.62LysTrp: 0.62 ± 0.01	1.267LysTyr: 1.267 ± 0.017	0.0LysXaa: 0.0 ± 0.0
Leu	8.256LeuAla: 8.256 ± 0.043	1.135LeuCys: 1.135 ± 0.017	5.233LeuAsp: 5.233 ± 0.037	5.623LeuGlu: 5.623 ± 0.038	3.117LeuPhe: 3.117 ± 0.023	6.103LeuGly: 6.103 ± 0.036	2.077LeuHis: 2.077 ± 0.022	3.552LeuIle: 3.552 ± 0.027	4.02LeuLys: 4.02 ± 0.032	8.249LeuLeu: 8.249 ± 0.056	1.752LeuMet: 1.752 ± 0.019	2.958LeuAsn: 2.958 ± 0.024	5.394LeuPro: 5.394 ± 0.033	3.597LeuGln: 3.597 ± 0.033	6.255LeuArg: 6.255 ± 0.039	6.789LeuSer: 6.789 ± 0.039	4.562LeuThr: 4.562 ± 0.029	5.4LeuVal: 5.4 ± 0.038	1.232LeuTrp: 1.232 ± 0.019	2.229LeuTyr: 2.229 ± 0.017	0.001LeuXaa: 0.001 ± 0.0
Met	2.29MetAla: 2.29 ± 0.021	0.226MetCys: 0.226 ± 0.007	1.233MetAsp: 1.233 ± 0.016	1.252MetGlu: 1.252 ± 0.018	0.7MetPhe: 0.7 ± 0.012	1.428MetGly: 1.428 ± 0.016	0.472MetHis: 0.472 ± 0.01	0.875MetIle: 0.875 ± 0.014	0.945MetLys: 0.945 ± 0.015	1.818MetLeu: 1.818 ± 0.02	0.543MetMet: 0.543 ± 0.011	0.739MetAsn: 0.739 ± 0.012	1.292MetPro: 1.292 ± 0.018	0.815MetGln: 0.815 ± 0.014	1.376MetArg: 1.376 ± 0.015	1.722MetSer: 1.722 ± 0.019	1.28MetThr: 1.28 ± 0.016	1.308MetVal: 1.308 ± 0.014	0.261MetTrp: 0.261 ± 0.006	0.499MetTyr: 0.499 ± 0.01	0.0MetXaa: 0.0 ± 0.0
Asn	3.168AsnAla: 3.168 ± 0.024	0.421AsnCys: 0.421 ± 0.009	1.889AsnAsp: 1.889 ± 0.019	1.952AsnGlu: 1.952 ± 0.019	1.266AsnPhe: 1.266 ± 0.017	3.062AsnGly: 3.062 ± 0.025	0.808AsnHis: 0.808 ± 0.013	1.796AsnIle: 1.796 ± 0.018	1.428AsnLys: 1.428 ± 0.016	3.049AsnLeu: 3.049 ± 0.025	0.783AsnMet: 0.783 ± 0.014	1.481AsnAsn: 1.481 ± 0.019	2.436AsnPro: 2.436 ± 0.023	1.235AsnGln: 1.235 ± 0.017	2.017AsnArg: 2.017 ± 0.016	2.568AsnSer: 2.568 ± 0.025	2.006AsnThr: 2.006 ± 0.018	2.172AsnVal: 2.172 ± 0.021	0.539AsnTrp: 0.539 ± 0.01	1.007AsnTyr: 1.007 ± 0.014	0.0AsnXaa: 0.0 ± 0.0
Pro	5.754ProAla: 5.754 ± 0.049	0.507ProCys: 0.507 ± 0.01	3.48ProAsp: 3.48 ± 0.025	4.124ProGlu: 4.124 ± 0.032	1.984ProPhe: 1.984 ± 0.021	4.499ProGly: 4.499 ± 0.048	1.323ProHis: 1.323 ± 0.017	2.305ProIle: 2.305 ± 0.021	2.593ProLys: 2.593 ± 0.026	4.787ProLeu: 4.787 ± 0.034	1.102ProMet: 1.102 ± 0.016	2.151ProAsn: 2.151 ± 0.021	5.553ProPro: 5.553 ± 0.08	2.47ProGln: 2.47 ± 0.029	3.796ProArg: 3.796 ± 0.031	5.757ProSer: 5.757 ± 0.044	3.961ProThr: 3.961 ± 0.041	3.63ProVal: 3.63 ± 0.031	0.755ProTrp: 0.755 ± 0.012	1.523ProTyr: 1.523 ± 0.02	0.0ProXaa: 0.0 ± 0.0
Gln	3.54GlnAla: 3.54 ± 0.028	0.405GlnCys: 0.405 ± 0.009	2.033GlnAsp: 2.033 ± 0.023	2.38GlnGlu: 2.38 ± 0.024	1.209GlnPhe: 1.209 ± 0.016	2.452GlnGly: 2.452 ± 0.025	1.048GlnHis: 1.048 ± 0.013	1.698GlnIle: 1.698 ± 0.018	1.847GlnLys: 1.847 ± 0.022	3.329GlnLeu: 3.329 ± 0.029	0.825GlnMet: 0.825 ± 0.013	1.392GlnAsn: 1.392 ± 0.016	2.599GlnPro: 2.599 ± 0.034	2.553GlnGln: 2.553 ± 0.047	2.699GlnArg: 2.699 ± 0.024	2.817GlnSer: 2.817 ± 0.026	2.145GlnThr: 2.145 ± 0.021	2.108GlnVal: 2.108 ± 0.019	0.54GlnTrp: 0.54 ± 0.011	1.116GlnTyr: 1.116 ± 0.016	0.0GlnXaa: 0.0 ± 0.0
Arg	5.471ArgAla: 5.471 ± 0.039	0.754ArgCys: 0.754 ± 0.012	3.927ArgAsp: 3.927 ± 0.033	4.218ArgGlu: 4.218 ± 0.029	2.223ArgPhe: 2.223 ± 0.02	4.369ArgGly: 4.369 ± 0.034	1.746ArgHis: 1.746 ± 0.019	2.94ArgIle: 2.94 ± 0.022	3.373ArgLys: 3.373 ± 0.027	5.923ArgLeu: 5.923 ± 0.042	1.373ArgMet: 1.373 ± 0.015	2.355ArgAsn: 2.355 ± 0.021	3.904ArgPro: 3.904 ± 0.034	2.742ArgGln: 2.742 ± 0.023	5.893ArgArg: 5.893 ± 0.041	4.821ArgSer: 4.821 ± 0.037	3.445ArgThr: 3.445 ± 0.027	3.685ArgVal: 3.685 ± 0.027	1.034ArgTrp: 1.034 ± 0.016	1.724ArgTyr: 1.724 ± 0.017	0.0ArgXaa: 0.0 ± 0.0
Ser	6.832SerAla: 6.832 ± 0.044	0.803SerCys: 0.803 ± 0.013	4.092SerAsp: 4.092 ± 0.029	4.1SerGlu: 4.1 ± 0.031	2.728SerPhe: 2.728 ± 0.022	5.773SerGly: 5.773 ± 0.032	1.769SerHis: 1.769 ± 0.018	3.413SerIle: 3.413 ± 0.027	3.386SerLys: 3.386 ± 0.029	6.632SerLeu: 6.632 ± 0.041	1.615SerMet: 1.615 ± 0.017	2.725SerAsn: 2.725 ± 0.023	5.393SerPro: 5.393 ± 0.051	3.027SerGln: 3.027 ± 0.027	5.103SerArg: 5.103 ± 0.037	8.234SerSer: 8.234 ± 0.069	5.062SerThr: 5.062 ± 0.039	4.385SerVal: 4.385 ± 0.03	1.089SerTrp: 1.089 ± 0.014	1.986SerTyr: 1.986 ± 0.021	0.0SerXaa: 0.0 ± 0.0
Thr	5.503ThrAla: 5.503 ± 0.034	0.709ThrCys: 0.709 ± 0.013	2.782ThrAsp: 2.782 ± 0.022	3.16ThrGlu: 3.16 ± 0.03	2.072ThrPhe: 2.072 ± 0.022	4.267ThrGly: 4.267 ± 0.029	1.182ThrHis: 1.182 ± 0.014	2.76ThrIle: 2.76 ± 0.025	2.409ThrLys: 2.409 ± 0.022	4.896ThrLeu: 4.896 ± 0.034	1.177ThrMet: 1.177 ± 0.014	1.925ThrAsn: 1.925 ± 0.02	4.314ThrPro: 4.314 ± 0.033	1.95ThrGln: 1.95 ± 0.022	3.274ThrArg: 3.274 ± 0.022	4.959ThrSer: 4.959 ± 0.043	4.247ThrThr: 4.247 ± 0.047	3.72ThrVal: 3.72 ± 0.032	0.851ThrTrp: 0.851 ± 0.014	1.55ThrTyr: 1.55 ± 0.017	0.0ThrXaa: 0.0 ± 0.0
Val	5.735ValAla: 5.735 ± 0.035	0.792ValCys: 0.792 ± 0.013	3.882ValAsp: 3.882 ± 0.025	4.022ValGlu: 4.022 ± 0.032	2.359ValPhe: 2.359 ± 0.021	4.146ValGly: 4.146 ± 0.03	1.387ValHis: 1.387 ± 0.016	2.809ValIle: 2.809 ± 0.022	2.823ValLys: 2.823 ± 0.028	5.658ValLeu: 5.658 ± 0.036	1.295ValMet: 1.295 ± 0.017	2.181ValAsn: 2.181 ± 0.023	3.73ValPro: 3.73 ± 0.029	2.286ValGln: 2.286 ± 0.021	3.828ValArg: 3.828 ± 0.028	4.431ValSer: 4.431 ± 0.031	3.55ValThr: 3.55 ± 0.032	4.486ValVal: 4.486 ± 0.034	0.884ValTrp: 0.884 ± 0.014	1.734ValTyr: 1.734 ± 0.019	0.001ValXaa: 0.001 ± 0.0
Trp	1.238TrpAla: 1.238 ± 0.015	0.191TrpCys: 0.191 ± 0.006	0.964TrpAsp: 0.964 ± 0.015	0.886TrpGlu: 0.886 ± 0.012	0.535TrpPhe: 0.535 ± 0.011	0.978TrpGly: 0.978 ± 0.016	0.355TrpHis: 0.355 ± 0.009	0.73TrpIle: 0.73 ± 0.011	0.75TrpLys: 0.75 ± 0.012	1.37TrpLeu: 1.37 ± 0.016	0.349TrpMet: 0.349 ± 0.008	0.593TrpAsn: 0.593 ± 0.009	0.631TrpPro: 0.631 ± 0.009	0.553TrpGln: 0.553 ± 0.01	1.062TrpArg: 1.062 ± 0.014	0.986TrpSer: 0.986 ± 0.017	0.872TrpThr: 0.872 ± 0.012	0.921TrpVal: 0.921 ± 0.015	0.275TrpTrp: 0.275 ± 0.008	0.407TrpTyr: 0.407 ± 0.01	0.0TrpXaa: 0.0 ± 0.0
Tyr	2.253TyrAla: 2.253 ± 0.022	0.399TyrCys: 0.399 ± 0.01	1.728TyrAsp: 1.728 ± 0.019	1.603TyrGlu: 1.603 ± 0.014	1.111TyrPhe: 1.111 ± 0.015	2.162TyrGly: 2.162 ± 0.024	0.732TyrHis: 0.732 ± 0.012	1.231TyrIle: 1.231 ± 0.014	1.041TyrLys: 1.041 ± 0.013	2.554TyrLeu: 2.554 ± 0.023	0.591TyrMet: 0.591 ± 0.009	1.023TyrAsn: 1.023 ± 0.015	1.481TyrPro: 1.481 ± 0.019	1.015TyrGln: 1.015 ± 0.015	1.709TyrArg: 1.709 ± 0.019	1.904TyrSer: 1.904 ± 0.021	1.487TyrThr: 1.487 ± 0.018	1.682TyrVal: 1.682 ± 0.018	0.454TyrTrp: 0.454 ± 0.009	0.93TyrTyr: 0.93 ± 0.015	0.0TyrXaa: 0.0 ± 0.0
Xaa	0.001XaaAla: 0.001 ± 0.0	0.0XaaCys: 0.0 ± 0.0	0.0XaaAsp: 0.0 ± 0.0	0.0XaaGlu: 0.0 ± 0.0	0.0XaaPhe: 0.0 ± 0.0	0.001XaaGly: 0.001 ± 0.0	0.0XaaHis: 0.0 ± 0.0	0.0XaaIle: 0.0 ± 0.0	0.0XaaLys: 0.0 ± 0.0	0.001XaaLeu: 0.001 ± 0.0	0.0XaaMet: 0.0 ± 0.0	0.0XaaAsn: 0.0 ± 0.0	0.0XaaPro: 0.0 ± 0.0	0.0XaaGln: 0.0 ± 0.0	0.001XaaArg: 0.001 ± 0.0	0.0XaaSer: 0.0 ± 0.0	0.0XaaThr: 0.0 ± 0.0	0.001XaaVal: 0.001 ± 0.0	0.0XaaTrp: 0.0 ± 0.0	0.0XaaTyr: 0.0 ± 0.0	0.015XaaXaa: 0.015 ± 0.003

Statistics based on 11997 proteins (5711890 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944

Contact: Lukasz P. Kozlowski

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