Amino acid dipepetide frequency for Streptococcus phage Javan444

Apart from single amino acid frequencies one can also calculate so called amino acid dipeptide frequency.

There is 400 possibilites (441 if we consider Xaa as additional 21st amino acid representing all non-standard or unknown amino acids). Thus, if the dipeptides would be present randomly in proteins each amino acid dipeptide should be present with 0.25% frequency. As it is not the case in the nature, for better visablity all more than expected dipepetides are marked by red, and those which are underrepresented are marked by blue in the table.

All values are presented as per milles (‰), therefore need to be multiplied by 10-3.

For more information see sequence space article on Wikipedia.

AlaCysAspGluPheGlyHisIleLysLeuMetAsnProGlnArgSerThrValTrpTyrXaa
Ala
4.929AlaAla: 4.929 ± 1.492
0.173AlaCys: 0.173 ± 0.131
4.929AlaAsp: 4.929 ± 1.101
5.447AlaGlu: 5.447 ± 0.621
3.286AlaPhe: 3.286 ± 0.982
6.053AlaGly: 6.053 ± 1.176
0.432AlaHis: 0.432 ± 0.214
5.793AlaIle: 5.793 ± 0.821
6.399AlaLys: 6.399 ± 0.595
7.004AlaLeu: 7.004 ± 1.255
2.681AlaMet: 2.681 ± 0.792
3.026AlaAsn: 3.026 ± 0.408
2.681AlaPro: 2.681 ± 0.445
3.632AlaGln: 3.632 ± 0.974
2.248AlaArg: 2.248 ± 0.476
4.929AlaSer: 4.929 ± 1.302
4.756AlaThr: 4.756 ± 1.089
4.323AlaVal: 4.323 ± 1.649
1.038AlaTrp: 1.038 ± 0.232
2.681AlaTyr: 2.681 ± 0.541
0.0AlaXaa: 0.0 ± 0.0
Cys
0.259CysAla: 0.259 ± 0.125
0.086CysCys: 0.086 ± 0.077
0.173CysAsp: 0.173 ± 0.115
0.259CysGlu: 0.259 ± 0.155
0.086CysPhe: 0.086 ± 0.088
0.346CysGly: 0.346 ± 0.214
0.173CysHis: 0.173 ± 0.164
0.086CysIle: 0.086 ± 0.098
0.259CysLys: 0.259 ± 0.166
0.259CysLeu: 0.259 ± 0.154
0.0CysMet: 0.0 ± 0.0
0.086CysAsn: 0.086 ± 0.096
0.086CysPro: 0.086 ± 0.09
0.173CysGln: 0.173 ± 0.177
0.086CysArg: 0.086 ± 0.089
0.346CysSer: 0.346 ± 0.167
0.173CysThr: 0.173 ± 0.128
0.086CysVal: 0.086 ± 0.076
0.086CysTrp: 0.086 ± 0.102
0.605CysTyr: 0.605 ± 0.229
0.0CysXaa: 0.0 ± 0.0
Asp
2.594AspAla: 2.594 ± 0.499
0.173AspCys: 0.173 ± 0.12
4.064AspAsp: 4.064 ± 0.912
5.015AspGlu: 5.015 ± 0.856
3.891AspPhe: 3.891 ± 0.643
5.275AspGly: 5.275 ± 0.991
0.778AspHis: 0.778 ± 0.271
3.545AspIle: 3.545 ± 0.723
5.966AspLys: 5.966 ± 0.839
3.718AspLeu: 3.718 ± 0.609
1.729AspMet: 1.729 ± 0.284
4.064AspAsn: 4.064 ± 0.59
1.383AspPro: 1.383 ± 0.495
1.47AspGln: 1.47 ± 0.343
2.421AspArg: 2.421 ± 0.508
2.681AspSer: 2.681 ± 0.45
5.188AspThr: 5.188 ± 0.805
3.372AspVal: 3.372 ± 0.57
1.038AspTrp: 1.038 ± 0.44
3.372AspTyr: 3.372 ± 0.89
0.0AspXaa: 0.0 ± 0.0
Glu
3.199GluAla: 3.199 ± 0.559
0.519GluCys: 0.519 ± 0.214
4.064GluAsp: 4.064 ± 0.95
5.447GluGlu: 5.447 ± 1.038
2.594GluPhe: 2.594 ± 0.447
3.199GluGly: 3.199 ± 0.529
0.951GluHis: 0.951 ± 0.275
4.842GluIle: 4.842 ± 0.716
5.015GluLys: 5.015 ± 0.956
7.696GluLeu: 7.696 ± 1.244
2.335GluMet: 2.335 ± 0.536
4.669GluAsn: 4.669 ± 0.713
1.989GluPro: 1.989 ± 0.449
4.496GluGln: 4.496 ± 0.702
3.805GluArg: 3.805 ± 0.578
2.421GluSer: 2.421 ± 0.453
2.508GluThr: 2.508 ± 0.505
4.842GluVal: 4.842 ± 0.773
0.778GluTrp: 0.778 ± 0.242
3.199GluTyr: 3.199 ± 0.621
0.0GluXaa: 0.0 ± 0.0
Phe
2.335PheAla: 2.335 ± 0.434
0.086PheCys: 0.086 ± 0.088
3.459PheAsp: 3.459 ± 0.556
3.026PheGlu: 3.026 ± 0.777
0.951PhePhe: 0.951 ± 0.301
2.162PheGly: 2.162 ± 0.568
0.346PheHis: 0.346 ± 0.186
2.508PheIle: 2.508 ± 0.503
3.199PheLys: 3.199 ± 0.554
3.372PheLeu: 3.372 ± 0.599
0.865PheMet: 0.865 ± 0.279
2.508PheAsn: 2.508 ± 0.433
0.346PhePro: 0.346 ± 0.187
1.383PheGln: 1.383 ± 0.347
0.692PheArg: 0.692 ± 0.22
3.459PheSer: 3.459 ± 0.877
3.026PheThr: 3.026 ± 0.493
2.075PheVal: 2.075 ± 0.431
0.432PheTrp: 0.432 ± 0.205
1.816PheTyr: 1.816 ± 0.51
0.0PheXaa: 0.0 ± 0.0
Gly
5.966GlyAla: 5.966 ± 0.854
0.173GlyCys: 0.173 ± 0.117
2.94GlyAsp: 2.94 ± 0.553
4.669GlyGlu: 4.669 ± 0.605
3.026GlyPhe: 3.026 ± 0.541
5.188GlyGly: 5.188 ± 0.768
0.605GlyHis: 0.605 ± 0.29
4.842GlyIle: 4.842 ± 1.078
5.447GlyLys: 5.447 ± 0.88
5.793GlyLeu: 5.793 ± 0.926
1.902GlyMet: 1.902 ± 0.531
4.323GlyAsn: 4.323 ± 0.646
0.605GlyPro: 0.605 ± 0.308
2.853GlyGln: 2.853 ± 0.64
3.632GlyArg: 3.632 ± 0.666
6.139GlySer: 6.139 ± 1.395
4.842GlyThr: 4.842 ± 1.12
5.275GlyVal: 5.275 ± 0.84
0.865GlyTrp: 0.865 ± 0.261
3.113GlyTyr: 3.113 ± 0.742
0.0GlyXaa: 0.0 ± 0.0
His
0.605HisAla: 0.605 ± 0.227
0.173HisCys: 0.173 ± 0.139
0.519HisAsp: 0.519 ± 0.238
0.605HisGlu: 0.605 ± 0.219
0.519HisPhe: 0.519 ± 0.219
0.519HisGly: 0.519 ± 0.237
0.432HisHis: 0.432 ± 0.192
0.692HisIle: 0.692 ± 0.247
1.124HisLys: 1.124 ± 0.352
1.383HisLeu: 1.383 ± 0.282
0.346HisMet: 0.346 ± 0.183
0.692HisAsn: 0.692 ± 0.264
0.432HisPro: 0.432 ± 0.174
1.038HisGln: 1.038 ± 0.292
0.346HisArg: 0.346 ± 0.17
0.692HisSer: 0.692 ± 0.211
0.778HisThr: 0.778 ± 0.232
0.605HisVal: 0.605 ± 0.253
0.173HisTrp: 0.173 ± 0.118
0.432HisTyr: 0.432 ± 0.256
0.0HisXaa: 0.0 ± 0.0
Ile
5.275IleAla: 5.275 ± 0.85
0.173IleCys: 0.173 ± 0.132
4.496IleAsp: 4.496 ± 0.635
5.361IleGlu: 5.361 ± 0.94
1.989IlePhe: 1.989 ± 0.457
4.15IleGly: 4.15 ± 0.797
1.211IleHis: 1.211 ± 0.301
4.237IleIle: 4.237 ± 0.602
7.09IleLys: 7.09 ± 0.93
3.286IleLeu: 3.286 ± 0.688
1.47IleMet: 1.47 ± 0.518
5.102IleAsn: 5.102 ± 0.808
2.508IlePro: 2.508 ± 0.566
1.989IleGln: 1.989 ± 0.367
3.286IleArg: 3.286 ± 0.513
5.015IleSer: 5.015 ± 0.69
4.237IleThr: 4.237 ± 0.663
2.94IleVal: 2.94 ± 0.519
0.519IleTrp: 0.519 ± 0.19
2.075IleTyr: 2.075 ± 0.522
0.0IleXaa: 0.0 ± 0.0
Lys
7.263LysAla: 7.263 ± 1.059
0.432LysCys: 0.432 ± 0.182
4.756LysAsp: 4.756 ± 0.885
5.015LysGlu: 5.015 ± 0.955
2.594LysPhe: 2.594 ± 0.443
5.102LysGly: 5.102 ± 0.734
0.778LysHis: 0.778 ± 0.231
5.275LysIle: 5.275 ± 0.68
5.88LysLys: 5.88 ± 1.192
5.015LysLeu: 5.015 ± 0.672
2.248LysMet: 2.248 ± 0.438
4.41LysAsn: 4.41 ± 0.564
1.816LysPro: 1.816 ± 0.427
3.632LysGln: 3.632 ± 0.898
3.891LysArg: 3.891 ± 0.806
4.842LysSer: 4.842 ± 0.693
4.842LysThr: 4.842 ± 0.657
6.485LysVal: 6.485 ± 0.757
1.643LysTrp: 1.643 ± 0.3
3.286LysTyr: 3.286 ± 0.832
0.0LysXaa: 0.0 ± 0.0
Leu
6.312LeuAla: 6.312 ± 1.098
0.173LeuCys: 0.173 ± 0.13
5.534LeuAsp: 5.534 ± 0.849
7.004LeuGlu: 7.004 ± 0.899
3.199LeuPhe: 3.199 ± 0.595
6.053LeuGly: 6.053 ± 0.944
1.47LeuHis: 1.47 ± 0.37
5.188LeuIle: 5.188 ± 0.632
6.831LeuLys: 6.831 ± 0.832
5.534LeuLeu: 5.534 ± 0.799
1.297LeuMet: 1.297 ± 0.248
4.929LeuAsn: 4.929 ± 0.726
2.508LeuPro: 2.508 ± 0.501
2.853LeuGln: 2.853 ± 0.633
2.853LeuArg: 2.853 ± 0.558
5.707LeuSer: 5.707 ± 0.664
4.323LeuThr: 4.323 ± 0.601
4.15LeuVal: 4.15 ± 0.777
0.778LeuTrp: 0.778 ± 0.23
1.383LeuTyr: 1.383 ± 0.37
0.0LeuXaa: 0.0 ± 0.0
Met
2.681MetAla: 2.681 ± 0.619
0.086MetCys: 0.086 ± 0.081
1.211MetAsp: 1.211 ± 0.257
1.124MetGlu: 1.124 ± 0.368
0.605MetPhe: 0.605 ± 0.223
1.556MetGly: 1.556 ± 0.389
0.173MetHis: 0.173 ± 0.123
1.124MetIle: 1.124 ± 0.326
2.421MetLys: 2.421 ± 0.53
1.902MetLeu: 1.902 ± 0.307
0.519MetMet: 0.519 ± 0.219
1.47MetAsn: 1.47 ± 0.303
0.346MetPro: 0.346 ± 0.182
1.297MetGln: 1.297 ± 0.508
1.124MetArg: 1.124 ± 0.293
2.421MetSer: 2.421 ± 0.544
2.94MetThr: 2.94 ± 0.611
1.383MetVal: 1.383 ± 0.614
0.259MetTrp: 0.259 ± 0.14
1.211MetTyr: 1.211 ± 0.297
0.0MetXaa: 0.0 ± 0.0
Asn
3.805AsnAla: 3.805 ± 0.606
0.259AsnCys: 0.259 ± 0.115
3.718AsnAsp: 3.718 ± 0.883
3.891AsnGlu: 3.891 ± 0.814
1.902AsnPhe: 1.902 ± 0.375
5.88AsnGly: 5.88 ± 1.166
0.519AsnHis: 0.519 ± 0.203
3.372AsnIle: 3.372 ± 0.709
4.496AsnLys: 4.496 ± 0.729
4.237AsnLeu: 4.237 ± 0.673
1.556AsnMet: 1.556 ± 0.324
3.026AsnAsn: 3.026 ± 0.591
2.853AsnPro: 2.853 ± 0.58
2.767AsnGln: 2.767 ± 0.561
1.643AsnArg: 1.643 ± 0.403
3.891AsnSer: 3.891 ± 0.636
3.026AsnThr: 3.026 ± 0.49
3.891AsnVal: 3.891 ± 0.614
0.778AsnTrp: 0.778 ± 0.259
1.816AsnTyr: 1.816 ± 0.407
0.0AsnXaa: 0.0 ± 0.0
Pro
1.989ProAla: 1.989 ± 0.44
0.086ProCys: 0.086 ± 0.102
1.729ProAsp: 1.729 ± 0.46
1.816ProGlu: 1.816 ± 0.407
1.124ProPhe: 1.124 ± 0.34
1.556ProGly: 1.556 ± 0.405
0.432ProHis: 0.432 ± 0.2
1.643ProIle: 1.643 ± 0.389
2.767ProLys: 2.767 ± 0.707
2.508ProLeu: 2.508 ± 0.589
0.605ProMet: 0.605 ± 0.219
0.951ProAsn: 0.951 ± 0.363
0.778ProPro: 0.778 ± 0.203
1.211ProGln: 1.211 ± 0.308
1.124ProArg: 1.124 ± 0.29
1.902ProSer: 1.902 ± 0.439
2.162ProThr: 2.162 ± 0.592
2.335ProVal: 2.335 ± 0.426
0.259ProTrp: 0.259 ± 0.153
1.297ProTyr: 1.297 ± 0.373
0.0ProXaa: 0.0 ± 0.0
Gln
5.102GlnAla: 5.102 ± 1.624
0.173GlnCys: 0.173 ± 0.117
1.47GlnAsp: 1.47 ± 0.375
2.94GlnGlu: 2.94 ± 0.62
0.865GlnPhe: 0.865 ± 0.272
3.372GlnGly: 3.372 ± 0.877
0.432GlnHis: 0.432 ± 0.277
2.853GlnIle: 2.853 ± 0.388
3.026GlnLys: 3.026 ± 0.587
3.632GlnLeu: 3.632 ± 0.697
0.865GlnMet: 0.865 ± 0.31
2.681GlnAsn: 2.681 ± 0.518
0.865GlnPro: 0.865 ± 0.268
1.643GlnGln: 1.643 ± 0.423
1.729GlnArg: 1.729 ± 0.36
2.853GlnSer: 2.853 ± 0.42
1.816GlnThr: 1.816 ± 0.321
2.94GlnVal: 2.94 ± 0.531
0.173GlnTrp: 0.173 ± 0.108
1.729GlnTyr: 1.729 ± 0.424
0.0GlnXaa: 0.0 ± 0.0
Arg
2.594ArgAla: 2.594 ± 0.454
0.086ArgCys: 0.086 ± 0.098
2.594ArgAsp: 2.594 ± 0.469
2.853ArgGlu: 2.853 ± 0.486
1.902ArgPhe: 1.902 ± 0.427
2.594ArgGly: 2.594 ± 0.418
0.346ArgHis: 0.346 ± 0.176
2.335ArgIle: 2.335 ± 0.439
3.286ArgLys: 3.286 ± 0.715
3.199ArgLeu: 3.199 ± 0.634
0.865ArgMet: 0.865 ± 0.295
2.162ArgAsn: 2.162 ± 0.462
1.383ArgPro: 1.383 ± 0.323
1.902ArgGln: 1.902 ± 0.443
1.556ArgArg: 1.556 ± 0.561
2.594ArgSer: 2.594 ± 0.459
2.162ArgThr: 2.162 ± 0.394
1.643ArgVal: 1.643 ± 0.357
0.778ArgTrp: 0.778 ± 0.341
2.421ArgTyr: 2.421 ± 0.535
0.0ArgXaa: 0.0 ± 0.0
Ser
6.399SerAla: 6.399 ± 2.213
0.173SerCys: 0.173 ± 0.117
5.102SerAsp: 5.102 ± 0.675
3.891SerGlu: 3.891 ± 0.637
2.162SerPhe: 2.162 ± 0.424
5.188SerGly: 5.188 ± 0.894
0.951SerHis: 0.951 ± 0.407
4.496SerIle: 4.496 ± 0.683
3.632SerLys: 3.632 ± 0.574
5.447SerLeu: 5.447 ± 0.808
1.816SerMet: 1.816 ± 0.351
3.113SerAsn: 3.113 ± 0.673
2.421SerPro: 2.421 ± 0.421
3.286SerGln: 3.286 ± 0.744
2.508SerArg: 2.508 ± 0.479
5.534SerSer: 5.534 ± 1.116
4.583SerThr: 4.583 ± 1.031
5.102SerVal: 5.102 ± 1.165
1.038SerTrp: 1.038 ± 0.415
2.508SerTyr: 2.508 ± 0.558
0.0SerXaa: 0.0 ± 0.0
Thr
5.966ThrAla: 5.966 ± 1.113
0.086ThrCys: 0.086 ± 0.089
3.286ThrAsp: 3.286 ± 0.553
3.891ThrGlu: 3.891 ± 0.621
3.026ThrPhe: 3.026 ± 0.526
4.929ThrGly: 4.929 ± 0.68
1.211ThrHis: 1.211 ± 0.398
5.447ThrIle: 5.447 ± 0.896
3.978ThrLys: 3.978 ± 0.693
5.015ThrLeu: 5.015 ± 0.618
1.124ThrMet: 1.124 ± 0.282
2.853ThrAsn: 2.853 ± 0.593
2.075ThrPro: 2.075 ± 0.434
2.162ThrGln: 2.162 ± 0.408
1.556ThrArg: 1.556 ± 0.374
5.447ThrSer: 5.447 ± 0.826
4.496ThrThr: 4.496 ± 0.851
5.188ThrVal: 5.188 ± 0.889
0.692ThrTrp: 0.692 ± 0.206
2.94ThrTyr: 2.94 ± 0.598
0.0ThrXaa: 0.0 ± 0.0
Val
5.707ValAla: 5.707 ± 1.114
0.086ValCys: 0.086 ± 0.098
3.891ValAsp: 3.891 ± 0.589
3.805ValGlu: 3.805 ± 0.56
1.989ValPhe: 1.989 ± 0.417
5.534ValGly: 5.534 ± 1.037
0.173ValHis: 0.173 ± 0.123
4.583ValIle: 4.583 ± 0.596
4.237ValLys: 4.237 ± 0.581
4.41ValLeu: 4.41 ± 0.636
1.729ValMet: 1.729 ± 0.42
3.199ValAsn: 3.199 ± 0.539
2.075ValPro: 2.075 ± 0.344
1.297ValGln: 1.297 ± 0.363
2.508ValArg: 2.508 ± 0.517
5.534ValSer: 5.534 ± 0.983
5.275ValThr: 5.275 ± 0.743
4.323ValVal: 4.323 ± 0.753
0.778ValTrp: 0.778 ± 0.245
2.767ValTyr: 2.767 ± 0.577
0.0ValXaa: 0.0 ± 0.0
Trp
1.124TrpAla: 1.124 ± 0.28
0.0TrpCys: 0.0 ± 0.0
0.605TrpAsp: 0.605 ± 0.253
0.519TrpGlu: 0.519 ± 0.206
0.605TrpPhe: 0.605 ± 0.188
0.951TrpGly: 0.951 ± 0.399
0.086TrpHis: 0.086 ± 0.09
0.692TrpIle: 0.692 ± 0.249
1.038TrpLys: 1.038 ± 0.371
0.692TrpLeu: 0.692 ± 0.217
0.346TrpMet: 0.346 ± 0.214
0.778TrpAsn: 0.778 ± 0.248
0.0TrpPro: 0.0 ± 0.0
0.432TrpGln: 0.432 ± 0.179
0.605TrpArg: 0.605 ± 0.232
1.038TrpSer: 1.038 ± 0.576
1.47TrpThr: 1.47 ± 0.565
1.211TrpVal: 1.211 ± 0.339
0.173TrpTrp: 0.173 ± 0.176
0.173TrpTyr: 0.173 ± 0.132
0.0TrpXaa: 0.0 ± 0.0
Tyr
2.335TyrAla: 2.335 ± 0.688
0.519TyrCys: 0.519 ± 0.273
3.199TyrAsp: 3.199 ± 0.795
2.075TyrGlu: 2.075 ± 0.478
1.729TyrPhe: 1.729 ± 0.575
2.594TyrGly: 2.594 ± 0.504
0.605TyrHis: 0.605 ± 0.25
2.853TyrIle: 2.853 ± 0.51
3.113TyrLys: 3.113 ± 0.559
3.978TyrLeu: 3.978 ± 0.7
1.47TyrMet: 1.47 ± 0.363
3.286TyrAsn: 3.286 ± 0.589
1.124TyrPro: 1.124 ± 0.318
1.643TyrGln: 1.643 ± 0.344
1.643TyrArg: 1.643 ± 0.459
1.902TyrSer: 1.902 ± 0.363
2.767TyrThr: 2.767 ± 0.443
1.729TyrVal: 1.729 ± 0.321
0.259TyrTrp: 0.259 ± 0.157
1.643TyrTyr: 1.643 ± 0.407
0.0TyrXaa: 0.0 ± 0.0
Xaa
0.0XaaAla: 0.0 ± 0.0
0.0XaaCys: 0.0 ± 0.0
0.0XaaAsp: 0.0 ± 0.0
0.0XaaGlu: 0.0 ± 0.0
0.0XaaPhe: 0.0 ± 0.0
0.0XaaGly: 0.0 ± 0.0
0.0XaaHis: 0.0 ± 0.0
0.0XaaIle: 0.0 ± 0.0
0.0XaaLys: 0.0 ± 0.0
0.0XaaLeu: 0.0 ± 0.0
0.0XaaMet: 0.0 ± 0.0
0.0XaaAsn: 0.0 ± 0.0
0.0XaaPro: 0.0 ± 0.0
0.0XaaGln: 0.0 ± 0.0
0.0XaaArg: 0.0 ± 0.0
0.0XaaSer: 0.0 ± 0.0
0.0XaaThr: 0.0 ± 0.0
0.0XaaVal: 0.0 ± 0.0
0.0XaaTrp: 0.0 ± 0.0
0.0XaaTyr: 0.0 ± 0.0
0.0XaaXaa: 0.0 ± 0.0
Statistics based on 52 proteins (11566 amino acids)

Note: The error has been estimated with the bootstraping (x100) at the protein level

Above dipeptide statistics (among other stats for this proteome) you can download from this CSV file
See this proteome in: uniprot_link
Proteome-pI is available under Creative Commons Attribution-NoDerivs license, for more details see here

Reference: Kozlowski LP. Proteome-pI 2.0: Proteome Isoelectric Point Database Update. Nucleic Acids Res. 2021, doi: 10.1093/nar/gkab944 Contact: Lukasz P. Kozlowski